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chr1:40,748,755-43,194,594

Best TWAS P=1.33e-33 · Best GWAS P=1.2e-27 conditioned to 0.0213

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Aorta	CTPS1	0.10	0.00	enet	8	0.00	4.6e-01	8.30	9.0	2.6e-19	0.75	0.05	0.59	FALSE
2	GTEx	Artery Coronary	CTPS1	0.25	-0.01	enet	23	0.00	3.0e-01	0.38	5.8	5.0e-09	0.39	0.07	0.13	FALSE
3	GTEx	Brain Cerebellum	HIVEP3	0.23	0.16	lasso	6	0.19	2.8e-06	4.77	5.3	1.1e-07	0.06	0.57	0.02	TRUE
4	GTEx	Breast Mammary Tissue (Female)	CTPS1	0.12	-0.01	lasso	4	-0.01	7.5e-01	7.59	6.7	2.1e-11	0.61	0.04	0.10	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	CTPS1	0.26	0.11	lasso	6	0.08	1.6e-03	8.93	8.5	1.5e-17	0.70	0.19	0.35	FALSE
6	GTEx	Lung	CTPS1	0.06	0.04	lasso	3	0.04	2.4e-04	9.22	9.5	3.0e-21	0.77	0.22	0.63	FALSE
7	GTEx	Nerve Tibial	SCMH1	0.16	0.03	enet	24	0.07	1.6e-05	10.53	-9.3	9.9e-21	-0.70	0.03	0.96	FALSE
8	GTEx	Testis	SLFNL1	0.30	0.17	lasso	14	0.28	5.3e-13	10.79	7.6	2.3e-14	0.85	0.01	0.99	FALSE
9	GTEx	Testis	CTPS1	0.57	0.28	enet	17	0.38	1.0e-17	-3.39	5.6	2.0e-08	0.48	0.97	0.03	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	CTPS1	0.04	0.04	enet	7	0.04	9.1e-06	7.56	5.7	9.9e-09	0.59	0.60	0.16	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLFNL1	0.03	0.01	enet	6	0.02	5.6e-05	-0.76	5.4	8.2e-08	0.58	0.11	0.74	FALSE
12	The Cancer Genome Atlas	Brain Lower Grade Glioma	CTPS	0.05	0.04	blup	49	0.03	1.0e-04	-3.39	5.3	1.3e-07	0.33	0.13	0.08	FALSE
13	The Cancer Genome Atlas	Brain Lower Grade Glioma	SCMH1	0.04	0.01	enet	7	0.02	2.5e-03	0.58	-7.2	5.0e-13	-0.70	0.01	0.81	FALSE
14	The Cancer Genome Atlas	Prostate Adenocarcinoma	SCMH1	0.03	0.03	lasso	2	0.02	6.2e-03	10.90	-10.9	1.2e-27	-1.00	0.01	0.96	FALSE
15	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SCMH1	0.35	0.14	blup	96	0.14	1.5e-05	-4.88	6.5	1.1e-10	0.47	0.17	0.26	FALSE
16	The Cancer Genome Atlas	Thyroid Carcinoma	SCMH1	0.07	0.08	blup	97	0.07	2.5e-07	10.54	-12.1	1.3e-33	-0.75	0.13	0.86	TRUE