[Hub]/) : Traits : Basal metabolic rate : ← →

chr1:37,628,741-40,737,589

Best TWAS P=1.6e-15 · Best GWAS P=5.41e-16 conditioned to 2.12e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
57	NTR	Blood	PABPC4	0.01	0.00	blup	383	0.00	2.8e-02	6.3	-8.0	1.6e-15	-0.68	0.05	0.48	TRUE
74	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FHL3	0.13	0.03	enet	6	0.05	4.9e-04	-5.8	6.2	5.7e-10	-0.07	0.00	0.94	TRUE
6	GTEx	Adrenal Gland	PABPC4	0.20	0.09	lasso	8	0.06	3.0e-03	6.3	-7.7	2.0e-14	-0.77	0.05	0.81	FALSE
20	GTEx	Breast Mammary Tissue (Female)	PABPC4	0.10	0.00	enet	9	0.01	1.5e-01	7.6	-7.5	7.5e-14	-0.83	0.03	0.48	FALSE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BMP8A	0.04	0.03	blup	48	0.04	3.5e-05	5.4	7.0	3.6e-12	0.68	0.02	0.97	FALSE
70	The Cancer Genome Atlas	Brain Lower Grade Glioma	BMP8A	0.05	0.01	blup	48	0.04	6.8e-05	7.3	6.9	5.3e-12	0.68	0.00	0.98	FALSE
46	GTEx	Skin Sun Exposed Lower leg	RP11-69E11.4	0.13	0.12	lasso	6	0.15	1.3e-12	6.9	6.8	7.3e-12	0.72	0.95	0.05	FALSE
1	CommonMind	Brain Pre-frontal Cortex	BMP8A	0.05	0.03	lasso	3	0.02	8.8e-04	6.5	6.8	1.1e-11	0.71	0.06	0.89	FALSE
78	The Cancer Genome Atlas	Thyroid Carcinoma	PABPC4	0.09	0.07	enet	5	0.08	4.1e-08	6.3	-6.8	1.1e-11	-0.62	0.00	1.00	FALSE
39	GTEx	Nerve Tibial	RP11-69E11.8	0.05	0.00	lasso	3	0.01	6.9e-02	6.3	-6.7	1.8e-11	-0.75	0.03	0.87	FALSE
42	GTEx	Skin Not Sun Exposed Suprapubic	PABPC4	0.12	0.10	lasso	3	0.05	1.0e-03	6.5	-6.7	2.7e-11	-0.71	0.28	0.42	FALSE
48	GTEx	Spleen	RP11-69E11.4	0.25	0.12	lasso	4	0.15	9.3e-05	5.4	6.6	3.5e-11	0.70	0.20	0.57	FALSE
25	GTEx	Esophagus Mucosa	PABPC4	0.06	0.06	lasso	3	0.08	7.3e-06	6.5	-6.6	3.7e-11	-0.73	0.34	0.60	FALSE
56	NTR	Blood	KIAA0754	0.03	0.00	bslmm	366	0.01	1.6e-03	-1.1	6.6	4.1e-11	0.62	0.09	0.77	FALSE
40	GTEx	Ovary	RP11-69E11.4	0.25	0.05	enet	11	0.03	6.7e-02	5.4	6.5	7.5e-11	0.68	0.05	0.42	FALSE
29	GTEx	Esophagus Mucosa	BMP8A	0.08	0.02	lasso	2	0.01	1.4e-01	-3.0	6.5	9.6e-11	0.69	0.08	0.86	FALSE
44	GTEx	Skin Sun Exposed Lower leg	PABPC4	0.11	0.09	lasso	7	0.08	2.7e-07	6.5	-6.4	1.5e-10	-0.71	0.37	0.63	FALSE
7	GTEx	Adrenal Gland	RP11-69E11.4	0.11	0.05	lasso	3	0.00	2.4e-01	5.3	6.4	1.7e-10	0.52	0.07	0.41	FALSE
22	GTEx	Cells Transformed fibroblasts	PABPC4	0.07	0.09	lasso	1	0.06	2.7e-05	6.3	-6.3	2.9e-10	-0.68	0.18	0.77	FALSE
12	GTEx	Artery Tibial	PABPC4	0.10	0.10	lasso	4	0.10	3.4e-08	6.3	-6.3	3.5e-10	-0.72	0.48	0.52	FALSE
64	The Cancer Genome Atlas	Breast Invasive Carcinoma	PABPC4	0.03	0.03	lasso	2	0.04	1.3e-08	6.3	-6.3	3.9e-10	-0.62	0.01	0.99	FALSE
36	GTEx	Nerve Tibial	PABPC4	0.17	0.08	enet	12	0.05	2.7e-04	6.3	-6.2	4.0e-10	-0.73	0.07	0.93	FALSE
49	GTEx	Spleen	BMP8A	0.16	0.08	lasso	3	0.05	1.6e-02	6.9	6.2	4.4e-10	0.75	0.07	0.31	FALSE
30	GTEx	Esophagus Mucosa	PPIEL	0.11	0.02	lasso	3	0.02	9.4e-03	6.7	6.2	4.6e-10	0.76	0.14	0.55	FALSE
72	The Cancer Genome Atlas	Lung Adenocarcinoma	PABPC4	0.04	0.03	enet	8	0.04	4.5e-05	6.5	-6.2	4.8e-10	-0.62	0.00	1.00	FALSE
26	GTEx	Esophagus Mucosa	RP11-69E11.4	0.18	0.06	lasso	9	0.07	2.2e-05	5.4	6.2	5.4e-10	0.64	0.80	0.18	FALSE
19	GTEx	Breast Mammary Tissue	PABPC4	0.13	0.02	enet	14	0.04	3.4e-03	6.5	-6.2	6.0e-10	-0.70	0.08	0.82	FALSE
8	GTEx	Adrenal Gland	FHL3	0.24	0.15	enet	17	0.34	7.4e-13	4.9	6.1	1.2e-09	-0.02	0.01	0.99	FALSE
67	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PABPC4	0.03	0.01	enet	4	0.02	4.3e-03	6.3	-6.1	1.3e-09	-0.68	0.00	0.99	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	BMP8A	0.05	0.01	lasso	6	0.02	5.5e-05	6.5	6.0	1.6e-09	0.55	0.41	0.30	FALSE
68	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PABPC4	0.04	0.05	blup	31	0.04	1.2e-05	5.2	-6.0	2.2e-09	-0.57	0.03	0.96	FALSE
41	GTEx	Pancreas	FHL3	0.17	0.05	lasso	3	0.10	6.6e-05	-5.8	6.0	2.4e-09	0.00	0.00	1.00	FALSE
37	GTEx	Nerve Tibial	RP11-69E11.4	0.18	0.08	lasso	5	0.18	1.3e-12	5.0	6.0	2.7e-09	0.66	0.57	0.43	FALSE
50	GTEx	Stomach	RP11-69E11.4	0.31	0.20	lasso	4	0.20	4.0e-10	5.4	5.9	4.1e-09	0.54	0.86	0.13	FALSE
65	The Cancer Genome Atlas	Colon Adenocarcinoma	FHL3	0.10	0.05	lasso	2	0.06	2.9e-04	5.3	5.9	4.3e-09	-0.04	0.00	0.97	FALSE
54	METSIM	Adipose	PABPC4	0.05	0.02	lasso	6	0.03	6.0e-05	6.5	-5.8	5.1e-09	-0.71	0.06	0.94	FALSE
2	GTEx	Adipose Subcutaneous	PABPC4	0.15	0.04	lasso	8	0.04	3.3e-04	3.3	-5.8	5.4e-09	-0.77	0.06	0.94	FALSE
73	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FHL3	0.08	0.08	lasso	2	0.08	1.4e-09	-5.8	5.7	9.6e-09	0.01	0.00	1.00	FALSE
10	GTEx	Artery Aorta	FHL3	0.35	0.22	lasso	4	0.27	3.9e-15	4.9	5.7	9.7e-09	-0.05	0.01	0.99	FALSE
33	GTEx	Lung	PABPC4	0.05	0.03	lasso	3	0.02	1.3e-02	6.3	-5.7	9.7e-09	-0.64	0.12	0.71	FALSE
34	GTEx	Lung	RP11-69E11.4	0.26	0.09	lasso	9	0.20	3.8e-15	-3.0	5.7	1.1e-08	0.49	0.94	0.06	FALSE
51	GTEx	Thyroid	PABPC4	0.08	0.03	lasso	6	0.05	1.3e-04	7.5	-5.7	1.2e-08	-0.78	0.10	0.87	FALSE
24	GTEx	Colon Transverse	RP11-69E11.4	0.23	0.12	lasso	4	0.15	1.8e-07	6.5	5.7	1.5e-08	0.67	0.31	0.68	FALSE
71	The Cancer Genome Atlas	Brain Lower Grade Glioma	INPP5B	0.05	0.03	blup	68	0.05	6.7e-06	4.8	5.7	1.5e-08	-0.05	0.03	0.96	FALSE
75	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPIEL	0.04	0.02	lasso	4	0.02	1.7e-03	5.4	5.7	1.5e-08	0.55	0.05	0.40	FALSE
47	GTEx	Skin Sun Exposed Lower leg	FHL3	0.15	0.09	lasso	5	0.10	1.2e-08	-5.8	5.6	1.9e-08	-0.01	0.00	1.00	FALSE
76	The Cancer Genome Atlas	Stomach Adenocarcinoma	FHL3	0.10	0.05	lasso	2	0.03	2.2e-03	-5.8	5.6	1.9e-08	-0.01	0.00	0.96	FALSE
14	GTEx	Artery Tibial	FHL3	0.13	0.11	lasso	2	0.13	1.1e-10	5.3	5.6	2.7e-08	-0.06	0.04	0.96	FALSE
52	GTEx	Thyroid	RP11-69E11.4	0.17	0.04	lasso	9	0.06	4.4e-05	5.4	5.5	2.9e-08	0.55	0.28	0.47	FALSE
58	NTR	Blood	SF3A3	0.10	0.12	lasso	6	0.13	7.2e-39	-5.8	-5.5	3.8e-08	0.01	0.00	1.00	FALSE
16	GTEx	Artery Tibial	UTP11L	0.09	0.14	lasso	3	0.12	1.1e-09	5.3	5.5	4.1e-08	-0.06	0.04	0.96	FALSE
5	GTEx	Adipose Visceral Omentum	FHL3	0.10	0.02	enet	9	0.00	1.9e-01	5.2	5.5	4.5e-08	-0.07	0.06	0.78	FALSE
17	GTEx	Brain Cerebellar Hemisphere	RP11-69E11.4	0.22	0.08	enet	16	0.08	4.5e-03	5.4	5.5	4.9e-08	0.63	0.21	0.49	FALSE
60	YFS	Blood	SF3A3	0.50	0.29	enet	44	0.44	3.2e-162	5.3	5.5	4.9e-08	0.00	0.04	0.96	FALSE
31	GTEx	Esophagus Muscularis	SF3A3	0.14	0.03	enet	13	0.06	2.9e-04	5.3	5.4	6.4e-08	-0.10	0.05	0.88	FALSE
53	METSIM	Adipose	FHL3	0.15	0.12	lasso	5	0.14	6.3e-20	-5.8	5.4	6.7e-08	-0.01	0.00	1.00	FALSE
23	GTEx	Cells Transformed fibroblasts	FHL3	0.24	0.17	lasso	4	0.15	1.4e-11	5.3	5.4	6.8e-08	-0.06	0.04	0.96	FALSE
35	GTEx	Lung	FHL3	0.14	0.07	enet	24	0.13	6.0e-10	4.8	5.4	6.8e-08	-0.01	0.02	0.98	FALSE
69	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PABPC4	0.05	0.05	enet	4	0.05	5.5e-04	6.5	-5.4	7.2e-08	-0.64	0.00	0.97	FALSE
45	GTEx	Skin Sun Exposed Lower leg	MACF1	0.08	0.08	lasso	2	0.06	5.3e-06	5.2	-5.3	8.8e-08	-0.70	0.47	0.53	FALSE
11	GTEx	Artery Coronary	RP11-109P14.10	0.26	0.10	enet	10	0.00	3.7e-01	4.9	5.3	9.0e-08	-0.07	0.02	0.96	FALSE
27	GTEx	Esophagus Mucosa	FHL3	0.14	0.14	lasso	5	0.12	3.4e-08	5.3	5.3	9.0e-08	-0.07	0.05	0.95	FALSE
4	GTEx	Adipose Subcutaneous	BMP8A	0.06	0.05	lasso	1	0.04	3.5e-04	5.3	5.3	9.2e-08	0.46	0.14	0.29	FALSE
38	GTEx	Nerve Tibial	FHL3	0.20	0.12	lasso	7	0.14	1.9e-10	4.6	5.3	9.8e-08	-0.05	0.02	0.98	FALSE
32	GTEx	Esophagus Muscularis	BMP8A	0.08	0.05	enet	10	0.05	3.5e-04	2.9	5.3	1.2e-07	0.69	0.26	0.65	FALSE
18	GTEx	Brain Frontal Cortex BA9	RP11-69E11.4	0.23	0.10	lasso	6	0.11	7.2e-04	5.2	5.3	1.3e-07	0.47	0.14	0.15	FALSE
43	GTEx	Skin Not Sun Exposed Suprapubic	FHL3	0.11	0.11	lasso	4	0.07	1.0e-04	5.2	5.3	1.3e-07	-0.05	0.02	0.97	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	FHL3	0.06	0.01	enet	10	0.01	4.2e-04	-5.8	5.3	1.3e-07	0.00	0.00	0.99	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	SF3A3	0.23	0.11	enet	18	0.09	5.8e-04	5.3	5.3	1.4e-07	-0.05	0.02	0.93	FALSE
9	GTEx	Artery Aorta	RP11-69E11.4	0.13	0.10	enet	14	0.14	2.5e-08	6.5	5.2	1.5e-07	0.63	0.68	0.31	FALSE
55	METSIM	Adipose	SF3A3	0.08	0.11	lasso	3	0.11	7.4e-16	5.3	5.2	1.5e-07	-0.07	0.07	0.93	FALSE
28	GTEx	Esophagus Mucosa	SF3A3	0.08	0.06	lasso	4	0.05	1.5e-04	5.3	5.2	1.9e-07	-0.07	0.06	0.93	FALSE
59	YFS	Blood	FHL3	0.69	0.49	enet	33	0.57	8.2e-237	3.2	5.2	2.1e-07	0.06	0.97	0.00	FALSE
13	GTEx	Artery Tibial	RP11-69E11.4	0.15	0.16	lasso	6	0.16	8.3e-13	5.4	5.2	2.2e-07	0.54	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	RP11-69E11.4	0.14	0.08	enet	22	0.10	1.4e-08	6.3	5.2	2.4e-07	0.59	0.99	0.01	FALSE
15	GTEx	Artery Tibial	SF3A3	0.16	0.11	enet	8	0.12	1.2e-09	4.9	5.2	2.5e-07	-0.06	0.08	0.92	FALSE
61	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FHL3	0.08	0.02	enet	7	0.03	1.1e-03	4.9	5.2	2.6e-07	0.02	0.00	0.95	FALSE
77	The Cancer Genome Atlas	Thyroid Carcinoma	FHL3	0.12	0.03	enet	8	0.03	6.4e-04	4.6	5.2	2.6e-07	-0.06	0.01	0.99	FALSE