Best TWAS P=5.84e-21 · Best GWAS P=2.46e-20 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | GHR | 0.25 | 0.07 | bslmm | 382 | 0.13 | 2.6e-15 | -6.1 | 6.4 | 1.7e-10 | 0.66 | 0.08 | 0.92 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | CCDC152 | 0.09 | 0.04 | lasso | 4 | 0.02 | 6.4e-03 | 9.2 | 9.3 | 1.7e-20 | 1.00 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | CCDC152 | 0.09 | 0.06 | lasso | 9 | 0.05 | 1.9e-03 | 9.1 | 8.6 | 1.3e-17 | 0.98 | 0.02 | 0.91 | FALSE |
| 4 | GTEx | Artery Aorta | CCDC152 | 0.31 | 0.24 | lasso | 8 | 0.24 | 2.5e-13 | 9.1 | 8.5 | 2.4e-17 | 0.98 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Artery Coronary | CCDC152 | 0.20 | 0.13 | lasso | 2 | 0.12 | 7.7e-05 | 9.1 | 9.1 | 6.3e-20 | 1.00 | 0.01 | 0.98 | FALSE |
| 6 | GTEx | Artery Tibial | CCDC152 | 0.22 | 0.17 | enet | 35 | 0.18 | 1.8e-14 | 9.1 | 7.0 | 1.8e-12 | 0.88 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Brain Frontal Cortex BA9 | GHR | 0.14 | 0.02 | lasso | 9 | 0.06 | 9.9e-03 | 7.2 | -5.7 | 1.5e-08 | -0.24 | 0.13 | 0.05 | TRUE |
| 8 | GTEx | Breast Mammary Tissue (Female) | SEPP1 | 0.15 | 0.00 | enet | 29 | 0.02 | 1.0e-01 | -1.8 | -5.3 | 1.4e-07 | -0.37 | 0.06 | 0.21 | TRUE |
| 9 | GTEx | Esophagus Muscularis | CCDC152 | 0.13 | 0.09 | lasso | 8 | 0.10 | 7.9e-07 | 8.0 | 7.9 | 2.4e-15 | 0.92 | 0.02 | 0.98 | TRUE |
| 10 | GTEx | Nerve Tibial | CCDC152 | 0.16 | 0.06 | enet | 25 | 0.06 | 2.9e-05 | 9.1 | 6.1 | 9.2e-10 | 0.81 | 0.02 | 0.98 | TRUE |
| 11 | GTEx | Stomach | SERBP1P6 | 0.12 | 0.03 | enet | 16 | 0.01 | 6.7e-02 | -4.2 | 6.9 | 4.5e-12 | 0.36 | 0.08 | 0.18 | TRUE |
| 12 | GTEx | Thyroid | C5orf34 | 0.08 | 0.08 | lasso | 3 | 0.06 | 1.4e-05 | 5.2 | 5.2 | 1.8e-07 | 0.22 | 0.00 | 0.99 | FALSE |
| 13 | GTEx | Thyroid | CCDC152 | 0.10 | 0.07 | lasso | 4 | 0.04 | 4.2e-04 | 9.1 | 9.2 | 5.1e-20 | 1.00 | 0.01 | 0.98 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | ZNF131 | 0.18 | 0.06 | lasso | 15 | 0.12 | 3.3e-15 | -3.7 | 5.3 | 1.1e-07 | 0.08 | 1.00 | 0.00 | TRUE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | CCDC152 | 0.20 | 0.09 | lasso | 10 | 0.09 | 5.2e-12 | 2.5 | 5.1 | 2.8e-07 | 0.52 | 0.96 | 0.04 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | SEPP1 | 0.18 | 0.19 | lasso | 11 | 0.21 | 1.3e-26 | 8.7 | -9.2 | 4.1e-20 | -0.98 | 0.01 | 0.99 | FALSE |
| 17 | YFS | Blood | CCDC152 | 0.07 | 0.06 | enet | 16 | 0.06 | 2.0e-19 | 9.2 | 9.4 | 5.8e-21 | 0.99 | 0.01 | 0.99 | TRUE |
| 18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SEPP1 | 0.01 | 0.00 | enet | 7 | 0.01 | 1.5e-03 | 8.7 | -7.1 | 1.3e-12 | -0.79 | 0.02 | 0.50 | TRUE |
| 19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC152 | 0.06 | 0.06 | blup | 40 | 0.07 | 1.6e-08 | 8.5 | -9.1 | 1.4e-19 | -0.95 | 0.03 | 0.97 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CCDC152 | 0.15 | 0.12 | lasso | 6 | 0.12 | 1.0e-12 | 8.7 | -8.7 | 3.6e-18 | -0.92 | 0.38 | 0.62 | TRUE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GHR | 0.12 | 0.11 | enet | 6 | 0.13 | 2.5e-13 | -7.2 | -7.8 | 4.2e-15 | -0.32 | 1.00 | 0.00 | FALSE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SEPP1 | 0.06 | 0.02 | blup | 38 | 0.04 | 5.2e-05 | 8.0 | -8.3 | 8.5e-17 | -0.79 | 0.22 | 0.71 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | MGC42105 | 0.04 | 0.01 | blup | 63 | 0.01 | 4.3e-02 | -3.6 | -5.5 | 2.8e-08 | -0.11 | 0.01 | 0.11 | FALSE |