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chr5:41,726,855-44,208,409

Best TWAS P=5.84e-21 · Best GWAS P=2.46e-20 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
17	YFS	Blood	CCDC152	0.07	0.06	enet	16	0.06	2.0e-19	9.2	9.4	5.8e-21	0.99	0.01	0.99	TRUE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC152	0.15	0.12	lasso	6	0.12	1.0e-12	8.7	-8.7	3.6e-18	-0.92	0.38	0.62	TRUE
9	GTEx	Esophagus Muscularis	CCDC152	0.13	0.09	lasso	8	0.10	7.9e-07	8.0	7.9	2.4e-15	0.92	0.02	0.98	TRUE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEPP1	0.01	0.00	enet	7	0.01	1.5e-03	8.7	-7.1	1.3e-12	-0.79	0.02	0.50	TRUE
11	GTEx	Stomach	SERBP1P6	0.12	0.03	enet	16	0.01	6.7e-02	-4.2	6.9	4.5e-12	0.36	0.08	0.18	TRUE
10	GTEx	Nerve Tibial	CCDC152	0.16	0.06	enet	25	0.06	2.9e-05	9.1	6.1	9.2e-10	0.81	0.02	0.98	TRUE
7	GTEx	Brain Frontal Cortex BA9	GHR	0.14	0.02	lasso	9	0.06	9.9e-03	7.2	-5.7	1.5e-08	-0.24	0.13	0.05	TRUE
14	ROSMAP	Brain Pre-frontal Cortex	ZNF131	0.18	0.06	lasso	15	0.12	3.3e-15	-3.7	5.3	1.1e-07	0.08	1.00	0.00	TRUE
8	GTEx	Breast Mammary Tissue (Female)	SEPP1	0.15	0.00	enet	29	0.02	1.0e-01	-1.8	-5.3	1.4e-07	-0.37	0.06	0.21	TRUE
2	GTEx	Adipose Subcutaneous	CCDC152	0.09	0.04	lasso	4	0.02	6.4e-03	9.2	9.3	1.7e-20	1.00	0.01	0.99	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	SEPP1	0.18	0.19	lasso	11	0.21	1.3e-26	8.7	-9.2	4.1e-20	-0.98	0.01	0.99	FALSE
13	GTEx	Thyroid	CCDC152	0.10	0.07	lasso	4	0.04	4.2e-04	9.1	9.2	5.1e-20	1.00	0.01	0.98	FALSE
5	GTEx	Artery Coronary	CCDC152	0.20	0.13	lasso	2	0.12	7.7e-05	9.1	9.1	6.3e-20	1.00	0.01	0.98	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC152	0.06	0.06	blup	40	0.07	1.6e-08	8.5	-9.1	1.4e-19	-0.95	0.03	0.97	FALSE
3	GTEx	Adipose Visceral Omentum	CCDC152	0.09	0.06	lasso	9	0.05	1.9e-03	9.1	8.6	1.3e-17	0.98	0.02	0.91	FALSE
4	GTEx	Artery Aorta	CCDC152	0.31	0.24	lasso	8	0.24	2.5e-13	9.1	8.5	2.4e-17	0.98	0.01	0.99	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEPP1	0.06	0.02	blup	38	0.04	5.2e-05	8.0	-8.3	8.5e-17	-0.79	0.22	0.71	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	GHR	0.12	0.11	enet	6	0.13	2.5e-13	-7.2	-7.8	4.2e-15	-0.32	1.00	0.00	FALSE
6	GTEx	Artery Tibial	CCDC152	0.22	0.17	enet	35	0.18	1.8e-14	9.1	7.0	1.8e-12	0.88	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	GHR	0.25	0.07	bslmm	382	0.13	2.6e-15	-6.1	6.4	1.7e-10	0.66	0.08	0.92	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	MGC42105	0.04	0.01	blup	63	0.01	4.3e-02	-3.6	-5.5	2.8e-08	-0.11	0.01	0.11	FALSE
12	GTEx	Thyroid	C5orf34	0.08	0.08	lasso	3	0.06	1.4e-05	5.2	5.2	1.8e-07	0.22	0.00	0.99	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	CCDC152	0.20	0.09	lasso	10	0.09	5.2e-12	2.5	5.1	2.8e-07	0.52	0.96	0.04	FALSE