Best TWAS P=9.54e-09 · Best GWAS P=5.1e-09 conditioned to 0.437
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PPHLN1 | 0.11 | 0.11 | enet | 12 | 0.13 | 8.5e-11 | 4.7 | -5.7 | 9.9e-09 | 0.67 | 0.43 | 0.56 | FALSE |
2 | GTEx | Artery Tibial | PPHLN1 | 0.12 | 0.07 | lasso | 5 | 0.09 | 2.3e-07 | -4.4 | -5.3 | 1.4e-07 | 0.92 | 0.03 | 0.97 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | PPHLN1 | 0.17 | 0.10 | enet | 24 | 0.17 | 1.3e-12 | -4.3 | -5.7 | 9.5e-09 | 0.88 | 0.02 | 0.98 | TRUE |
4 | GTEx | Cells Transformed fibroblasts | ZCRB1 | 0.09 | 0.03 | enet | 18 | 0.08 | 2.4e-06 | -4.5 | -5.2 | 1.9e-07 | 0.66 | 0.16 | 0.74 | FALSE |
5 | GTEx | Esophagus Muscularis | ZCRB1 | 0.13 | 0.10 | lasso | 2 | 0.08 | 2.4e-05 | -5.6 | -5.7 | 1.1e-08 | 0.97 | 0.00 | 1.00 | FALSE |
6 | GTEx | Lung | ZCRB1 | 0.10 | 0.14 | enet | 13 | 0.13 | 5.6e-10 | -5.6 | -5.7 | 1.5e-08 | 0.95 | 0.00 | 1.00 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | PRICKLE1 | 0.13 | 0.01 | lasso | 7 | 0.00 | 1.7e-01 | 5.0 | 5.2 | 1.6e-07 | -0.08 | 0.11 | 0.31 | TRUE |
8 | GTEx | Thyroid | GXYLT1 | 0.11 | 0.09 | enet | 20 | 0.12 | 2.8e-09 | -3.4 | -5.3 | 1.4e-07 | 0.69 | 0.88 | 0.10 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZCRB1 | 0.04 | 0.01 | blup | 34 | 0.01 | 1.8e-02 | -3.9 | -5.7 | 1.5e-08 | 0.93 | 0.01 | 0.28 | FALSE |