Hub : Genes

PRICKLE1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.069	0.0230	0.00014	0.010	0.040	0.030	0.039	0.019	1.9e-02	1.2e-05	1.2e-04	1.4e-05	2.0e-03
2	GTEx	Brain Cerebellar Hemisphere	0.304	0.0880	0.00017	0.237	NA	0.215	NA	0.253	9.0e-07	NA	3.1e-06	NA	3.6e-07
3	GTEx	Brain Cerebellum	0.211	0.0720	0.00220	0.089	NA	0.128	NA	0.088	1.4e-03	NA	1.3e-04	NA	1.4e-03
4	GTEx	Skin Sun Exposed Lower leg	0.128	0.0460	0.00200	0.005	NA	0.002	NA	0.003	1.0e-01	NA	2.3e-01	NA	1.7e-01
5	YFS	Blood	0.107	0.0186	0.00000	0.158	0.144	0.158	0.159	0.159	2.3e-49	8.9e-45	2.4e-49	1.4e-49	1.5e-49
6	TCGA	Bladder Urothelial Carcinoma	0.076	0.0380	0.00470	-0.002	0.018	0.015	NA	0.001	5.2e-01	1.1e-02	1.9e-02	NA	2.3e-01
7	TCGA	Testicular Germ Cell Tumors	0.145	0.0680	0.00800	0.058	0.010	0.070	NA	0.091	4.2e-03	1.3e-01	1.8e-03	NA	4.1e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.1	0.1	0.3	0.3	0.5	-0.1	0.0	0.1	0.0	-0.4
Bipolar Disorder or Schizophrenia	0.3	0.8	1.3	0.1	-0.8	-1.0	-1.0	1.1	-0.8	-1.1
Depressed Affect (Nagel 2018)	1.2	2.5	5.6	-0.9	-2.4	-2.3	-0.3	2.2	0.8	0.5
Depression (Nagel 2018)	1.2	1.8	3.9	-0.4	-1.8	-2.0	-0.4	2.0	0.8	0.7
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.9	-1.1	0.0	1.1	0.4	-0.6	-0.9	1.7
Neuroticism (Nagel 2018)	0.7	1.8	3.6	-0.8	-1.7	-1.7	-0.3	1.9	1.4	0.5
Schizophrenia (2018)	0.7	1.4	2.3	-0.1	-1.5	-1.2	-1.3	1.4	-1.1	-1.0
Schizophrenia vs Biploar Disorder	0.3	0.4	1.4	0.1	0.2	-0.1	-1.2	0.3	-0.9	-0.4
Worry (Nagel 2018)	0.1	0.2	0.6	0.2	0.6	0.0	-0.6	0.2	0.8	0.1
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	0.5	0.1	0.6	-0.1	0.3	0.6	-0.6
Alzheimer’s Disease (in father)	0.4	0.5	1.2	0.7	0.7	0.2	-0.1	-1.1	0.3	-1.1
Alzheimer’s Disease (including proxy)	0.2	0.3	0.9	0.5	0.6	0.3	-0.3	-0.2	0.7	-1.0
Crohns Disease (2017)	0.5	1.1	3.8	0.2	-1.5	-1.9	-0.4	0.3	-0.5	-1.1
Irritable Bowel Disease (IBD)	0.5	1.3	2.9	-0.4	-1.5	-1.7	0.4	0.7	0.1	-1.7
Ulcerative Colitis (UC)	0.3	0.6	1.7	-0.7	-0.7	-0.4	0.9	0.2	0.6	-1.3
Major Depression (MDD)	1.4	1.7	3.8	-0.2	-1.6	-1.9	-0.5	1.3	1.4	1.2
Reaction Time	1.3	2.4	10.9	0.1	1.3	1.0	-1.4	-1.1	-0.1	3.3
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.8	-1.3	-0.8	0.3	1.2	0.8	0.0	0.4
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	1.2	1.7	5.4	0.7	2.3	1.3	0.0	-1.9	-0.5	0.6
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.8	1.2	3.4	0.9	-1.3	-0.5	-1.8	0.9	-1.0	-0.3
Bipolar Disorder (2011)	1.0	1.0	2.5	-0.1	1.0	1.2	1.4	-1.6	-0.3	-0.0
Body Mass Index (BMI) (2010)	0.3	0.4	2.3	0.2	-0.3	-0.5	-1.5	0.0	-0.4	-0.3
Coronary Artery Disease (CAD)	1.2	1.4	6.6	1.1	0.5	-0.4	-2.6	0.1	-1.4	0.2
Crohns Disease (2012)	0.4	0.7	1.5	0.3	-0.2	-0.4	-0.9	-0.7	-1.2	-1.2
Mean Putamen Volume	0.4	0.5	1.3	-0.1	-0.3	1.1	-1.1	0.1	-0.4	0.8
Fasting Glucose	0.2	0.2	0.7	-0.9	-0.2	-0.0	-0.6	0.5	0.5	-0.1
HbA1C	0.7	0.7	2.5	0.0	-0.3	-1.0	-1.6	0.3	0.3	1.2
HDL Cholesterol	0.1	0.2	0.5	-0.7	-0.1	-0.4	-0.4	-0.1	0.6	-0.6
LDL Cholesterol	0.3	0.5	1.3	0.2	1.2	0.2	-0.7	-0.3	-0.9	-1.0
Lupus	0.5	0.8	1.8	-1.2	-0.1	-0.9	1.3	0.9	0.5	0.6
Neuroticism (2016)	2.4	3.5	9.7	2.1	2.1	1.5	-3.1	-1.8	-0.1	-0.7
Primary Biliary Cirrhosis	0.4	0.5	0.9	-0.9	0.8	-0.4	-0.7	-0.9	-1.0	0.2
Rheumatoid Arthritis	1.3	1.8	6.6	-0.4	1.5	1.4	-0.2	-0.7	-1.2	-2.6
Schizophrenia (2014)	0.4	0.8	1.9	0.3	-1.4	-0.7	-1.0	1.2	-0.6	-0.5
Triglycerides	0.6	1.1	2.5	1.6	0.9	1.1	-0.5	-1.1	-0.4	-1.0
Type 2 Diabetes (T2D) (2012)	2.1	2.4	11.0	-1.8	-0.3	0.3	3.3	0.1	1.2	1.0
Ulcerative Colitis	0.5	0.7	1.3	-0.9	-0.8	-0.9	0.9	0.9	-0.1	-1.2
Blood Eosinophil Count	0.1	1.0	2.7	0.1	1.1	0.5	-0.9	-1.1	-1.6	-0.6
Blood Platelet Count	0.8	9.7	12.2	-3.5	-3.1	-2.9	1.8	3.2	3.5	3.5
Blood Red Count	0.1	1.2	2.6	0.6	0.5	1.3	-1.5	-1.6	-0.8	0.9
Blood White Count	0.3	2.4	4.7	0.5	2.1	1.9	0.5	-2.2	-0.0	1.9
Heel T-Score	0.2	1.5	7.0	-0.3	-1.0	-0.2	-0.9	1.0	0.6	-2.6
BMI	1.0	5.5	20.2	2.4	-1.6	-2.4	-4.5	0.6	-1.7	-1.2
Height	0.2	4.8	12.3	2.7	2.2	3.5	-0.7	-2.0	-1.3	-1.8
Waist Hip Ratio (WHR)	0.4	1.7	5.9	-0.1	-0.5	0.5	2.2	0.2	2.4	0.6
Systolic Blood Pressure	0.2	1.0	5.5	0.2	0.3	0.2	-1.0	-0.2	-0.6	-2.4
Smoking Status	0.5	1.2	2.9	-0.7	1.4	0.4	1.3	-1.0	-1.7	-0.6
Allergy or Eczema	0.2	0.4	1.6	-0.1	0.5	0.0	0.4	0.7	0.6	1.3
Cardiovascular Disease	0.9	2.8	9.7	0.8	-1.6	-2.2	-3.1	1.4	-0.1	0.4
Hypothyroidism (self reported)	0.7	1.6	5.2	1.6	0.4	-0.6	-1.0	-0.3	-2.3	-1.3
Respiratory disease	0.3	0.7	1.3	-0.8	-1.1	-0.6	-0.9	0.3	-1.1	0.9
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.3	1.2	-1.8	-1.6	-1.8	1.2	-0.2	0.4
Lung FEV1/FVC ratio	0.3	1.3	3.8	0.8	1.0	1.9	0.8	-1.2	0.6	-1.1
Lung FVC	1.4	7.2	14.6	2.4	3.8	1.8	-2.3	-3.7	-2.7	-0.7
Neuroticism	0.4	1.0	2.4	-0.1	-1.2	-1.0	-0.8	0.7	1.5	1.0
Chronotype (morning person)	0.3	0.7	4.1	-0.3	-0.2	0.4	-0.9	0.0	2.0	-0.0
Hair Pigment	0.1	2.3	6.5	0.8	-1.7	-2.5	0.5	2.4	0.2	-0.2
Tanning	0.1	1.0	4.0	0.6	0.6	-1.2	-0.3	0.0	-2.0	-0.8
Hand grip strength (left)	1.0	2.7	8.3	0.1	1.7	0.1	-1.7	-0.7	-2.2	-2.9
Number of treatments/medications taken	0.9	1.6	5.9	0.8	-1.2	-2.4	-1.5	0.7	0.4	0.5
Average weekly spirits intake	1.3	1.6	3.2	0.4	1.3	1.6	0.7	-1.7	-0.3	-1.8
Sensitivity / hurt feelings	0.3	0.5	1.4	0.3	0.0	-1.0	-1.2	0.2	0.3	-0.8
Frequency of depressed mood in last 2 weeks	1.1	1.6	3.7	-0.2	-1.9	-1.3	-0.7	1.5	0.6	1.5
Hearing difficulty/problems: Yes	1.8	2.7	7.0	-0.1	-2.5	-2.1	-0.6	2.6	1.0	0.4
Relative age of first facial hair	1.0	2.1	5.0	0.5	0.9	1.3	-0.2	-1.8	-1.8	-2.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.5	1.2	0.9	0.5	-1.2	-0.9	0.4	1.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.2	0.3	-0.2	-0.6	0.5	0.1	0.5	1.5
Ever had hysterectomy (womb removed)	0.6	0.6	2.7	-0.1	-0.2	-0.2	-1.6	-0.3	-0.2	-1.2
Systolic blood pressure, automated reading	0.3	0.8	1.9	0.6	0.9	0.7	-1.0	-0.8	-0.8	-1.4
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	5.2	2.3	0.6	0.4	-1.9	-0.5	-1.7	-1.7
Angina	0.3	0.4	2.0	0.1	-0.7	0.3	0.5	-0.1	-0.5	-1.4
Medication for hormone replacement therapy	0.7	0.7	2.6	-0.0	-0.0	-0.7	-0.2	-0.5	-1.3	-1.6
Vitamin and mineral supplements	1.0	1.3	4.8	0.2	-0.7	-0.6	-1.3	0.6	-2.2	-1.1
Supplements: Zinc	1.5	1.6	2.9	0.1	-0.5	-1.5	1.5	1.6	1.0	1.7
Medication: Co-codamol	0.9	1.0	3.2	-1.8	0.6	0.2	1.5	-0.9	0.7	-0.0
Medication: Metformin	0.6	0.9	3.3	0.5	-0.5	-0.8	-1.8	0.8	0.5	1.0
Diabetes (father)	5.0	6.2	11.7	-1.7	-3.2	-3.3	0.7	3.4	2.5	0.6
Diabetes (mother)	0.5	0.6	2.6	0.8	0.4	0.1	-0.8	0.3	-1.6	-0.6
Severe depression (siblings)	0.5	0.5	2.7	0.6	0.1	-0.4	-1.7	0.1	0.5	0.3
Pack years adult smoking proportion	0.4	0.7	1.9	0.5	-1.4	-1.4	0.1	0.8	-0.3	-0.3
Impedance of leg (right)	1.2	5.7	22.6	-1.3	0.2	1.4	4.7	0.7	3.4	1.3
Leg fat-free mass (left)	1.1	5.9	23.2	1.9	-1.3	-1.6	-4.8	0.3	-2.8	-1.4
Trunk fat percentage	0.8	3.0	8.8	0.4	-2.5	-3.0	-1.2	1.8	-1.2	-0.0
Hand grip strength (right)	1.5	4.0	10.7	1.7	0.7	-0.3	-2.2	-0.3	-3.0	-3.3
Townsend deprivation index at recruitment	1.2	1.7	7.0	0.3	1.3	1.0	0.1	-1.1	-0.9	2.6
Current tobacco smoking	0.4	0.7	1.2	-0.6	0.9	0.6	1.1	-0.7	-1.0	-0.9
Average weekly fortified wine intake	0.7	0.8	2.1	0.4	0.9	0.0	0.2	-1.1	-1.3	-1.4
Maternal smoking around birth	0.4	0.6	1.3	0.3	-0.6	-1.0	-0.3	0.6	1.0	1.1
Fed-up feelings	1.1	2.0	5.8	0.6	-2.4	-1.9	-1.3	1.5	-0.5	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.1	3.8	-1.0	-1.7	-2.0	-0.1	1.7	0.6	1.9
Relative age voice broke	1.2	1.8	3.2	0.3	1.7	1.8	0.2	-1.3	-1.6	-1.3
Taking other prescription medications	1.2	1.9	7.7	-0.2	-1.9	-2.8	-0.0	1.0	-1.0	0.4
Age when periods started (menarche)	0.6	1.4	5.2	-2.3	-0.6	0.7	1.2	0.4	1.2	0.9
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	3.7	0.4	0.9	1.2	-0.0	-1.3	-1.9	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	5.4	0.9	-1.4	-0.9	-2.3	1.1	-0.4	-1.3
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	3.5	0.6	-0.2	-0.8	-1.1	-0.0	-1.0	-1.9
Qualifications: CSEs or equivalent	0.4	0.5	2.4	-0.1	-0.1	-0.3	0.0	1.5	0.8	0.7
Serious illness, injury or assault to yourself	0.9	1.1	3.8	-0.3	-0.7	-0.6	-1.9	0.1	-1.6	0.8
High blood pressure	1.0	2.7	11.2	0.0	-1.2	-1.5	-3.3	0.8	0.0	1.8
Hayfever, allergic rhinitis or eczema	0.2	0.5	2.6	-0.2	0.7	0.3	0.3	0.6	-0.0	1.6
Multivitamins +/- minerals	0.5	0.7	2.1	0.9	0.9	0.6	0.6	-0.4	1.5	0.4
Stomach or abdominal pain in last month	0.2	0.2	1.0	1.0	-0.3	0.2	0.1	-0.5	0.3	-0.2
Supplements: Glucosamine	1.2	1.5	5.7	0.5	-0.3	-1.8	-2.4	0.9	0.7	0.0
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.1	0.5	-0.7	-0.3	0.3	-0.8	1.0	0.2
Medication: Atenolol	1.7	2.1	9.2	3.0	0.8	0.5	-1.6	-0.8	-0.5	-1.0
Medication: Levothyroxine sodium	0.3	0.6	1.1	0.6	-0.5	-1.0	-0.1	0.4	-1.0	-1.1
Sitting height	0.1	0.9	2.6	0.2	-1.0	0.4	-1.6	0.7	-1.3	-0.6
Chronic bronchitis/emphysema (father)	0.8	1.0	4.8	2.2	-0.5	-0.5	-0.8	0.1	-0.7	0.6
High blood pressure (mother)	0.5	0.7	2.8	0.7	-0.2	-0.4	-1.7	0.7	0.7	0.3
Body mass index (BMI)	1.5	6.2	16.5	1.5	-2.4	-3.3	-4.1	1.2	-2.5	-0.8
Impedance of leg (left)	1.0	4.9	19.9	-1.2	1.0	2.3	4.5	-0.2	2.7	0.1
Leg predicted mass (left)	1.1	5.8	22.9	1.9	-1.3	-1.6	-4.8	0.3	-2.7	-1.5
Trunk fat mass	0.8	3.4	6.9	1.1	-2.3	-2.6	-2.4	1.3	-1.7	-0.6
Waist circumference	0.8	2.8	8.1	1.5	-1.8	-2.3	-2.8	0.5	-0.8	0.1
Number of incorrect matches in round	0.8	1.3	1.7	1.3	1.2	1.3	1.1	-1.0	0.5	-1.3
Past tobacco smoking	0.4	0.8	2.1	0.3	-1.4	-0.1	0.0	1.2	1.1	-0.8
Alcohol usually taken with meals	1.1	1.7	5.2	-0.7	-1.3	-0.9	1.4	1.3	2.3	-0.5
Nervous feelings	0.2	0.3	1.2	0.5	1.1	0.9	0.1	0.1	0.3	0.2
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.3	0.5	-1.7	-1.3	-1.8	1.2	0.0	1.1
Hearing difficulty/problems with background noise	0.6	1.0	3.0	-0.1	-1.2	-0.8	-1.7	1.3	0.4	-0.0
Hair/balding pattern: Pattern 2	1.0	1.3	3.5	-1.4	-1.9	-1.0	0.1	1.3	0.2	0.5
Had menopause	1.5	1.9	7.4	-0.9	0.4	-0.0	0.9	-0.4	1.9	2.7
Had other major operations	0.7	0.9	2.3	0.3	-1.1	-1.3	-1.5	0.7	-0.5	-0.2
Forced vital capacity (FVC)	1.5	5.8	7.6	2.7	2.6	1.8	-2.7	-2.6	-2.3	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	5.3	0.4	-0.8	-0.3	-2.3	0.5	-0.2	-0.7
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	7.0	-2.6	-1.5	-0.9	1.0	0.7	0.6	0.5
Qualifications: None of the above	0.3	0.7	2.5	-1.6	0.8	0.2	0.5	-1.2	-0.1	0.5
Financial difficulties in last 2 years	1.2	1.6	3.7	-1.8	-1.0	-1.9	-0.3	1.1	-1.2	-0.1
Mouth/teeth dental problems	0.8	1.3	4.5	1.6	0.6	0.1	-2.1	-0.3	-0.4	1.2
Heart attack	0.9	1.1	3.9	-1.1	-2.0	-0.5	1.0	1.1	0.5	0.0
Allergy	0.1	0.3	0.9	0.8	-0.2	-0.1	0.3	-0.2	0.3	-0.9
Pain all over the body in last month	0.9	0.9	2.7	0.7	0.4	0.7	0.5	-0.6	1.4	1.6
Diabetes (self-reported)	1.0	1.5	3.7	1.1	-1.0	-1.9	-1.9	1.0	0.3	0.4
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.3	0.7	1.5	0.9	-0.6	-0.9	-1.5	-1.4
Medication: Ramipril	0.9	1.2	4.2	2.0	-0.7	-0.1	-1.6	0.1	0.9	-0.4
Medication: Simvastatin	0.6	0.9	4.3	0.5	-0.2	-0.8	0.0	0.1	0.9	2.1
Fluid intelligence score	0.3	0.7	2.1	-1.1	-1.4	-0.0	0.0	0.4	-0.1	1.0
Illnesses of siblings	0.8	1.1	2.8	0.3	1.1	1.1	0.9	-1.7	-1.1	-0.9
Neuroticism score	0.2	0.5	0.9	-0.1	-0.9	-0.8	-0.9	0.7	0.8	-0.2
Weight	1.1	5.4	17.1	2.0	-1.6	-2.1	-4.1	0.5	-2.8	-1.4
Impedance of arm (right)	1.4	6.7	25.1	-2.4	-0.2	-0.2	5.0	1.6	2.8	2.3
Arm fat percentage (right)	1.3	5.1	14.2	0.9	-2.6	-3.8	-2.6	2.0	-1.7	0.4
Trunk fat-free mass	1.2	6.9	24.7	2.7	0.8	0.6	-5.0	-1.7	-2.8	-2.1
Hip circumference	1.2	5.2	17.3	1.6	-2.2	-2.9	-4.2	0.7	-1.6	-0.0
Time employed in main current job	0.1	0.2	0.6	0.5	-0.2	0.1	-0.8	-0.2	-0.3	0.4
Alcohol intake versus 10 years previously	0.9	1.3	7.1	-0.9	-0.0	-0.2	0.7	0.3	0.8	2.7
Father’s age at death	0.9	1.2	2.4	-1.6	-1.3	-0.9	-0.8	1.3	-0.0	1.1
Worrier / anxious feelings	0.2	0.4	1.0	-0.3	0.1	-0.5	-0.5	-0.4	0.9	1.0
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	7.4	-0.9	-2.7	-1.9	-0.2	1.6	1.0	2.2
Falls in the last year	0.8	1.1	2.2	1.0	0.0	-0.6	-1.4	-0.8	1.5	1.4
Hair/balding pattern: Pattern 3	1.9	2.8	6.2	1.0	2.2	2.2	0.1	-2.5	-1.2	-1.0
Number of live births	0.2	0.3	0.8	-0.7	0.4	-0.4	0.6	0.1	-0.6	-0.9
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	7.4	2.7	1.4	1.5	-2.7	-1.4	-1.4	-2.0
Pulse rate	0.2	0.4	0.7	0.5	-0.0	0.9	0.8	-0.8	0.7	-0.0
Happiness	0.2	0.3	0.8	0.8	-0.1	0.6	0.1	-0.5	-0.0	-0.9
Noisy workplace	0.1	0.1	0.2	-0.2	0.4	0.4	-0.5	0.3	0.2	-0.2
Qualifications: A levels/AS levels or equivalent	1.2	2.7	9.1	2.7	0.1	0.8	-3.0	0.2	-1.1	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.3	0.6	-1.1	-0.4	-0.7	1.0	-0.1	0.8
Mouth/teeth dental problems: Dentures	1.1	1.9	9.9	-1.4	0.2	-0.1	3.1	-0.6	-0.7	-0.6
Asthma	0.5	1.0	3.7	-1.9	-1.4	-0.5	-0.2	-0.1	-0.3	1.1
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	10.8	3.3	1.5	1.3	-2.1	-0.6	-0.6	0.6
Medication: Cholesterol lowering	0.2	0.4	1.1	0.0	-0.7	-1.1	-0.7	0.7	-0.3	0.1
Depression (self-reported)	0.9	1.0	3.0	1.2	0.7	0.4	-1.7	-1.1	-0.9	-0.0
Medication: Lansoprazole	0.9	1.0	3.8	-0.7	-2.0	-1.4	-0.0	0.4	0.4	0.6
Prospective memory result	0.5	0.6	1.8	-1.3	-0.4	-0.9	0.4	1.1	0.4	0.4
Lung cancer (father)	0.4	0.5	2.9	0.0	-0.1	-0.5	-0.4	0.2	0.0	1.7
Illnesses of mother	2.4	3.0	5.5	1.1	1.8	2.3	-0.1	-2.4	-1.5	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	6.8	2.6	1.6	1.3	-2.3	-1.5	-1.8	-2.3
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	0.7	-0.3	0.3	0.4	-0.0	0.7	0.2
Impedance of arm (left)	1.3	6.2	26.3	-2.3	-0.3	0.4	5.1	1.3	2.7	1.5
Arm fat mass (right)	1.2	4.9	12.5	1.5	-2.3	-3.0	-3.5	1.1	-2.1	-0.0
Trunk predicted mass	1.2	6.9	24.4	2.7	0.8	0.7	-4.9	-1.8	-2.8	-2.2
Standing height	0.2	2.1	4.9	1.2	1.3	2.2	-0.8	-1.4	-0.9	-1.9
Length of working week for main job	0.2	0.2	0.9	-0.2	-0.4	0.3	-0.0	-0.2	0.9	-0.3
Exposure to tobacco smoke at home	0.4	0.5	1.7	-0.5	0.7	-0.8	-0.4	-0.2	-1.3	0.2
Breastfed as a baby	0.6	0.7	1.3	-1.1	-1.1	-0.2	-0.9	0.4	-1.1	-0.7
Tense / ‘highly strung’	0.2	0.4	0.9	0.3	-0.8	-0.3	-0.9	0.3	-0.2	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.4	-0.9	-1.0	-1.6	0.2	0.4	0.9	0.9
Hair/balding pattern: Pattern 4	0.9	2.2	6.1	-0.6	-1.8	-2.2	0.2	2.5	0.1	-0.9
Birth weight of first child	0.4	0.7	1.6	1.0	-0.5	0.6	-1.2	0.0	-0.5	-1.3
Peak expiratory flow (PEF)	1.0	2.3	6.1	1.5	0.8	1.2	-1.6	-1.3	-1.2	-2.5
Pulse wave reflection index	0.4	0.5	1.5	-0.9	-0.8	-0.6	0.2	1.2	0.2	0.5
Ever highly irritable/argumentative for 2 days	1.8	2.2	5.7	-0.1	-2.1	-2.0	-0.7	2.4	0.4	0.3
Loud music exposure frequency	1.3	1.4	2.8	1.7	1.7	0.9	0.1	-1.1	-1.4	0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.2	0.6	-0.4	0.1	-0.5	1.1	0.1	0.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.1	1.1	0.0	0.2	-0.8	0.1	-0.2	-0.5
Blood clot in the leg (DVT)	0.5	0.6	1.8	-1.0	-0.3	-0.3	0.3	0.9	1.3	-0.5
Medication: Paracetamol	1.7	2.8	7.9	2.5	1.4	0.4	-2.8	-1.5	-1.1	0.2
Headache pain in last month	0.2	0.4	1.4	-0.2	-0.5	-0.2	-0.3	0.0	-0.9	-1.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.2	-0.5	1.0	1.5	1.0	-0.9	-0.2	0.4
Glaucoma (self-reported)	0.9	1.0	4.7	0.8	0.7	-0.1	-0.9	-0.6	-0.5	-2.2
Gout (self-reported)	2.3	3.2	8.2	0.5	0.8	2.9	-1.0	-2.5	-1.7	-1.8
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.4	1.5	0.2	-1.2	-0.6	0.0	-1.9	-1.0
Medication: Amlodipine	0.1	0.1	0.3	-0.6	-0.3	-0.2	-0.1	-0.2	0.2	0.0
Medication: Ventolin 100micrograms inhaler	0.5	0.6	2.3	-0.7	0.2	-0.1	-1.2	-0.5	-0.2	1.5
Birth weight	0.4	0.9	3.7	-0.8	-1.1	-0.4	-1.9	0.7	-0.3	-0.4
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.7	1.6	-1.4	-1.4	-0.6	1.3	0.1	0.5
High blood pressure (siblings)	1.8	2.5	7.1	-0.6	-1.3	-0.7	-2.7	2.0	1.3	1.6
Forced vital capacity (FVC), Best measure	1.7	6.4	8.0	2.7	2.7	1.9	-2.4	-2.6	-2.8	-2.3
Body fat percentage	0.8	3.3	9.6	0.6	-2.5	-3.1	-1.6	1.8	-1.1	-0.0
Leg fat percentage (right)	0.7	2.6	7.2	1.1	-2.2	-2.7	-1.7	1.4	-0.6	-0.0
Arm fat-free mass (right)	1.3	6.7	26.6	2.7	-0.2	-0.2	-5.2	-0.9	-2.6	-2.2
Exposure to tobacco smoke outside home	0.6	0.7	2.4	-0.2	-1.3	-1.6	0.1	0.8	-0.8	0.1
Comparative body size at age 10	0.6	1.8	5.7	-0.6	-0.8	-0.9	-2.4	0.9	-0.8	-1.9
Number of full brothers	1.6	2.0	4.2	-0.2	-1.9	-2.0	0.8	1.8	-1.3	0.4
Worry too long after embarrassment	0.8	1.3	3.1	-0.1	1.7	1.6	-0.5	-1.8	-0.1	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	5.3	-0.9	-1.7	-2.3	-0.5	2.3	0.8	0.4
Wheeze or whistling in the chest in last year	0.3	0.5	1.6	-1.0	0.4	-0.1	-0.2	-0.8	-0.3	1.3
Number of children fathered	0.3	0.3	0.7	-0.2	0.2	0.5	0.6	-0.6	0.9	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.0	0.1	1.4	0.9	-0.6	-0.8	-1.0	-0.1
Age at first live birth	0.5	0.8	3.6	0.5	0.2	0.5	-1.9	-0.0	-0.2	-1.2
Pulse wave peak to peak time	0.2	0.2	0.5	-0.7	0.5	0.1	-0.2	-0.2	-0.6	-0.4
Health satisfaction	0.8	1.0	2.7	0.7	-1.4	-1.1	-1.6	0.9	-0.3	0.0
Shortness of breath walking on level ground	0.3	0.3	1.2	0.1	-0.4	0.4	1.1	-0.2	0.8	0.2
Qualifications: College or University degree	0.1	0.2	0.8	0.1	-0.5	0.9	-0.2	-0.5	0.1	0.4
Eye problems/disorders: None of the above	0.4	0.5	2.0	-0.4	0.3	0.6	0.7	-0.1	0.3	1.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.2	0.4	-0.4	0.8	1.1	-0.0	0.3	-0.7
Emphysema/chronic bronchitis	0.5	0.6	1.7	1.0	0.8	-0.3	0.3	0.0	-0.9	-1.3
Medication for pain relief, constipation, heartburn	1.0	1.8	6.7	-2.6	-1.2	-0.1	1.8	0.6	0.0	-0.6
Neck or shoulder pain in last month	0.4	0.6	3.1	-0.4	-0.4	-0.0	-1.8	0.1	-0.7	-0.6
Medication: Blood pressure	0.1	0.2	0.8	-0.0	0.3	-0.2	-0.9	-0.3	0.4	-0.5
Angina (self-reported)	0.3	0.3	1.2	-0.1	-0.9	0.1	0.5	0.1	-0.3	-1.1
Migraine (self-reported)	1.0	1.3	2.4	1.3	1.2	0.8	-0.4	-1.4	-1.6	-0.7
Medication: Ibuprofen	1.6	1.9	9.1	3.0	0.9	0.3	-1.7	-0.0	-0.2	0.7
Medication: Allopurinol	2.1	2.8	6.8	-0.4	1.3	2.2	0.8	-2.6	-1.9	-1.5
Medication: Omeprazole	1.4	1.7	4.0	-1.2	-0.6	-1.7	0.3	1.3	2.0	1.2
Medication: Seretide 50 evohaler	0.6	0.7	1.9	-0.6	-1.4	-1.0	-0.1	0.9	1.0	0.4
Mean time to correctly identify matches	1.5	2.9	9.9	0.3	2.0	1.9	-0.7	-1.5	0.3	3.2
Heart disease (mother)	1.4	1.7	3.2	-0.5	-1.7	-1.3	0.2	1.5	1.4	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	2.6	-1.6	0.2	1.0	1.0	0.2	0.5	0.7
Whole body fat mass	1.0	4.0	8.8	1.1	-2.3	-2.8	-3.0	1.3	-1.8	-0.4
Leg fat mass (right)	1.0	4.0	9.8	1.3	-2.4	-2.7	-3.1	1.2	-1.5	-0.3
Arm predicted mass (right)	1.2	6.0	23.9	2.4	-0.4	-0.2	-4.9	-0.9	-2.7	-2.0
Pulse rate, automated reading	0.3	1.0	2.2	-1.1	-1.5	-1.2	0.7	0.6	0.2	1.1
Alcohol intake frequency.	0.3	0.8	2.1	-0.5	-0.6	-1.2	1.0	0.2	0.4	1.5
Comparative height size at age 10	0.4	2.4	5.0	1.6	2.1	1.4	-1.4	-2.2	-0.3	0.8
Number of full sisters	0.7	0.9	2.2	1.5	0.4	-0.3	-0.8	0.7	-1.1	-1.2
Suffer from ‘nerves’	0.3	0.4	1.5	0.1	0.4	0.5	0.9	0.4	1.2	-0.2
Overall health rating	1.2	2.6	6.5	1.1	-1.0	-2.1	-2.5	1.2	-0.3	2.0
Chest pain or discomfort	1.9	2.7	6.6	-1.4	-2.6	-1.5	0.2	1.9	1.9	1.0
Had major operations	0.4	0.4	1.6	-1.2	-0.1	-0.2	0.8	0.8	0.3	0.3
Age at last live birth	0.2	0.3	1.1	0.1	0.5	0.3	-1.1	-0.1	0.1	-0.7
Family relationship satisfaction	2.2	2.6	4.8	-2.0	0.6	1.2	1.7	-0.7	2.2	2.2
Leg pain on walking	0.4	0.5	1.1	0.7	-0.4	-0.8	-1.0	0.3	-1.0	-0.0
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	4.2	0.8	-1.4	-1.8	0.7	2.1	-0.4	-0.3
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	0.1	0.3	0.3	0.3	-0.3	0.2	-0.4
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.5	0.7	0.4	1.5	1.1	-0.9	1.9	-0.3
Medication: Aspirin	0.3	0.3	0.8	0.9	0.9	0.3	0.1	-0.4	0.3	0.6
Supplements: Vitamin C	0.5	0.6	1.3	-1.2	0.1	-0.0	1.1	0.7	1.1	0.2
Knee pain experienced in last month	0.3	0.4	1.2	1.1	0.3	-0.1	-0.5	-0.4	-0.8	-0.7
Hypertension (Self-reported)	0.8	2.3	9.7	-0.1	-0.9	-1.3	-3.1	0.7	-0.2	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.2	4.9	11.0	-1.0	-3.2	-3.3	-0.2	2.3	2.0	1.7
Illnesses of father: Heart disease	0.7	0.9	2.3	-0.2	-1.5	-0.6	0.2	1.4	1.1	-0.6
Illnesses of siblings: Diabetes	0.3	0.4	1.0	-0.3	-0.5	-0.6	-0.5	0.1	0.8	1.0
Smoking status: Previous	0.3	0.5	0.9	0.4	0.7	-0.7	-0.7	-0.6	-0.9	0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	6.5	2.1	1.1	0.7	-1.3	-0.7	-1.0	-2.5
Whole body fat-free mass	1.2	6.7	26.7	2.5	-0.1	-0.3	-5.2	-1.0	-2.9	-2.1
Leg fat-free mass (right)	1.2	6.4	24.7	2.0	-0.8	-1.0	-5.0	-0.4	-3.2	-2.1
Arm fat percentage (left)	1.2	4.8	12.1	1.0	-2.7	-3.5	-2.6	1.9	-1.8	0.0
Average weekly red wine intake	0.3	0.4	1.3	-0.3	-1.2	-0.2	0.4	0.7	0.9	-0.2
Handedness (chirality/laterality): Left-handed	0.9	1.1	4.8	-0.4	-0.2	-0.4	-1.2	1.1	2.2	-0.1
Mood swings	0.6	1.2	4.6	-0.6	-2.1	-1.1	0.2	1.2	0.4	-0.2
Loneliness, isolation	3.4	4.7	7.3	-2.7	-2.6	-1.6	0.2	2.1	2.4	2.5
Long-standing illness, disability or infirmity	1.1	1.7	3.4	1.3	-1.3	-1.5	-1.5	1.1	0.2	1.8
Ever had bowel cancer screening	2.5	2.9	7.6	-0.0	-1.8	-0.9	0.6	1.7	2.8	2.4
Diabetes diagnosed by doctor	1.0	1.7	4.3	1.0	-1.2	-2.1	-1.9	1.2	0.2	0.3
Ever had stillbirth, spontaneous miscarriage or termination	2.6	2.8	7.2	-1.6	-2.1	-2.0	0.2	2.7	1.2	0.6
Friendships satisfaction	0.4	0.5	1.3	-0.1	1.2	0.5	-0.5	-1.2	0.2	-0.1
Qualifications: nursing, teaching	0.8	1.3	4.1	1.0	-1.3	-1.3	-0.6	2.0	0.0	0.1
Commuting to job workplace: Walk	1.3	1.4	3.4	-1.4	-1.4	-0.6	0.6	1.8	1.1	-0.6
Eye problems/disorders: Cataract	0.7	0.8	2.4	0.8	-0.4	-0.4	-1.5	0.1	-1.6	0.0
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	9.2	-1.4	-0.5	-0.8	1.5	1.6	3.0	0.1
Medication for cholesterol	1.0	1.5	3.8	-2.0	0.5	1.0	1.6	-0.4	1.6	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.1	-0.1	-1.5	-0.8	0.4	0.6	0.4	-0.1
Back pain experienced in last month	0.2	0.4	1.1	-0.6	0.1	-0.1	-0.5	0.8	1.0	0.3
Mineral and other dietary supplements	0.6	0.8	4.8	0.3	-0.7	0.4	0.1	-0.2	-2.2	-0.5
Breast cancer (self-reported)	1.0	1.2	4.7	-2.2	-0.4	0.7	1.6	0.1	0.3	0.4
Asthma (self-reported)	0.5	0.9	2.3	-1.5	-1.2	-0.4	-0.6	-0.3	-0.6	1.3
Osteoporosis (self-reported)	1.7	2.1	5.8	-0.0	1.6	0.9	1.1	-2.4	1.0	1.8
Osteoarthritis (self-reported)	0.3	0.4	1.0	0.8	-0.0	0.0	-0.4	-1.0	0.4	1.0
Medication: Aspirin	0.4	0.5	1.9	0.9	0.3	-0.4	0.0	0.1	0.8	1.4
Medication: Gliclazide	0.7	0.8	2.0	0.3	1.4	0.5	-1.3	-1.1	-0.1	0.7
Illnesses of father: None of the above (group 1)	2.4	3.0	7.3	0.9	2.7	1.9	-1.1	-2.7	-0.8	0.6
Smoking status: Current	0.6	0.9	1.5	-0.8	0.9	0.8	1.1	-0.9	-1.2	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	9.7	2.8	0.7	0.1	-3.1	-0.8	-1.3	-1.5
Whole body water mass	1.2	6.7	27.1	2.5	-0.1	-0.4	-5.2	-0.9	-2.9	-2.1
Leg predicted mass (right)	1.2	6.2	24.1	1.9	-0.9	-1.1	-4.9	-0.3	-3.1	-2.0
Arm fat mass (left)	1.4	5.6	13.5	1.5	-2.5	-3.0	-3.7	1.3	-2.4	-0.6
Number of self-reported non-cancer illnesses	1.2	2.1	8.5	1.0	-1.3	-1.5	-2.9	0.2	-0.4	1.1
Average weekly champagne plus white wine intake	0.5	0.6	2.5	0.9	-0.8	0.0	-1.6	0.6	0.1	-0.4
Miserableness	0.2	0.3	1.0	0.6	-0.4	-1.0	-0.0	-0.3	-0.4	-0.5
Guilty feelings	1.5	2.2	3.0	-1.6	-1.6	-1.3	-1.7	1.6	0.4	1.7
Wears glasses or contact lenses	1.8	2.1	3.8	-1.7	-0.8	-1.4	0.7	1.1	1.9	1.9
Ever taken oral contraceptive pill	1.1	1.2	3.8	-0.9	-1.1	-2.0	-0.4	0.8	-0.6	1.1
Hearing aid user	0.5	0.5	1.2	1.1	0.1	-0.4	-1.0	0.0	-0.9	-0.5
Mother’s age at death	0.3	0.4	1.4	-0.6	-0.4	-1.2	0.2	0.9	-0.0	0.5
Financial situation satisfaction	2.9	3.6	7.8	1.6	1.9	1.4	-2.1	-1.5	-2.8	-1.5
Tinnitus: Yes, now most or all of the time	4.8	5.7	9.0	-1.8	-2.5	-2.9	0.4	2.8	3.0	2.2
Commuting to job workplace: Public transport	0.1	0.2	0.6	0.3	0.2	0.1	-0.1	-0.8	-0.6	0.3
Eye problems/disorders: Glaucoma	0.6	0.7	3.6	-0.3	0.1	-0.2	0.7	-0.6	0.3	-1.9
Medication: Blood pressure	0.3	0.5	1.6	0.3	0.1	-0.7	-1.3	0.4	-0.4	1.0
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.4	0.9	0.7	1.6	-0.6	-1.5	-0.6	-0.2
Supplements: Fish oil (including cod liver oil)	0.9	1.1	6.1	-0.1	1.0	-0.0	0.6	-0.5	2.5	0.4
High cholesterol (Self-reported)	0.6	1.0	3.8	1.9	-0.7	-1.1	-0.5	0.3	-0.4	1.1
Medication: Bendroflumethiazide	0.4	0.6	2.5	-0.3	1.6	0.9	0.1	-0.7	-0.2	0.2
Medication: Paracetamol	1.5	2.3	7.0	2.1	1.4	-0.2	-2.6	-1.4	-0.5	0.5
Medication: Lisinopril	1.4	1.8	4.2	-1.3	-2.1	-2.1	-0.8	1.1	-0.5	-0.7
Medication: Atorvastatin	0.7	0.8	1.8	0.1	-0.9	-0.6	-1.3	0.9	-1.2	-0.8
Illnesses of father: High blood pressure	0.5	0.6	1.5	-1.1	0.5	0.9	-0.2	-1.2	-0.1	-0.6
Alcohol drinker status: Never	0.4	0.5	1.7	0.2	-0.3	-0.9	-0.2	-0.5	0.8	1.3
Ever smoked	0.6	1.0	2.4	-0.7	1.6	0.7	1.1	-0.9	-0.8	1.0
Basal metabolic rate	1.2	6.6	26.5	2.5	-0.5	-0.8	-5.2	-0.6	-3.0	-1.9
Leg fat percentage (left)	0.6	2.3	5.2	1.2	-1.7	-2.3	-2.0	0.7	-1.1	-0.9
Arm fat-free mass (left)	1.4	7.2	27.9	2.9	0.1	-0.2	-5.3	-1.1	-3.0	-1.9
Number of operations (self-reported)	0.9	1.4	3.5	-0.8	-1.9	-1.6	0.4	1.3	0.9	0.5
Average weekly beer plus cider intake	0.9	1.3	3.4	1.5	1.8	1.1	-1.0	-1.0	-0.7	0.2
Irritability	1.6	2.8	6.0	-1.8	-2.4	-1.8	0.7	1.6	1.7	1.0
Risk taking	0.3	0.4	1.4	0.7	-1.2	0.0	0.0	0.2	0.3	0.9
Ever had prostate specific antigen (PSA) test	1.0	1.2	4.2	-0.8	-0.7	-0.5	1.3	0.9	2.0	0.4
Fractured/broken bones in last 5 years	0.2	0.3	0.9	0.9	-0.1	-0.2	-0.8	-0.3	-0.3	0.6
Age started oral contraceptive pill	1.0	1.2	6.1	-0.3	-0.4	-0.2	0.4	-0.1	1.4	2.5
Diastolic blood pressure, automated reading	0.7	2.1	5.6	-0.4	-1.8	-2.4	-1.7	1.5	0.5	-0.7
Ever depressed for a whole week	1.0	1.2	2.5	-1.6	-1.6	-1.4	0.5	0.2	1.2	-0.2
Unable to work because of sickness or disability	0.9	1.2	5.9	-0.3	0.0	-1.4	0.0	0.3	-0.4	2.4
Commuting to job workplace: Cycle	0.7	0.9	4.8	-0.2	0.2	0.3	0.9	0.6	0.1	-2.2
Myopia	0.7	1.0	2.2	-0.3	1.1	1.1	1.5	0.2	1.2	0.6
Vascular/heart problems diagnosed by doctor	0.9	2.5	8.6	0.1	1.9	1.8	2.9	-1.2	0.1	-0.8
Cholesterol lowering medication	0.5	0.7	2.6	1.1	-0.5	-0.5	-0.3	0.7	0.2	1.6
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	3.0	-1.3	-0.5	-1.5	0.5	1.3	1.7	1.2
Pain experienced in last month	0.3	0.5	1.0	0.5	-0.1	-0.7	1.0	0.8	0.2	1.0
Supplements: Calcium	1.2	1.3	3.7	-1.4	-0.5	-0.4	1.2	0.2	1.3	1.9
Basal cell carcinoma (self-reported)	0.9	1.1	2.9	-0.5	-1.4	-0.7	-0.3	0.7	1.3	1.7
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.8	-0.9	-1.9	-0.5	0.8	1.2	0.5	0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.9	-0.6	-0.4	-0.6	-0.3	1.0	1.4	-0.2
Heart disease (siblings)	0.5	0.6	2.9	1.7	0.6	0.3	-0.4	-0.7	0.4	0.3
Alcohol drinker status: Previous	0.2	0.2	0.7	0.1	-0.5	0.5	0.1	-0.2	-0.5	-0.8
Pack years of smoking	0.4	0.6	1.8	0.6	-1.2	-1.3	-0.2	0.6	-0.5	-0.3
Impedance of whole body	1.2	6.1	27.5	-1.8	-0.1	1.0	5.2	1.2	2.9	1.0
Leg fat mass (left)	1.0	3.9	10.8	1.3	-2.1	-2.5	-3.3	0.8	-1.7	-0.7
Arm predicted mass (left)	1.2	6.0	25.2	2.5	-0.3	-0.6	-5.0	-0.8	-2.6	-1.6