TWAS hub - PRICKLE1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.069	0.0230	0.00014	0.010	0.040	0.030	0.039	0.019	1.9e-02	1.2e-05	1.2e-04	1.4e-05	2.0e-03
2	GTEx	Brain Cerebellar Hemisphere	0.304	0.0880	0.00017	0.237	NA	0.215	NA	0.253	9.0e-07	NA	3.1e-06	NA	3.6e-07
3	GTEx	Brain Cerebellum	0.211	0.0720	0.00220	0.089	NA	0.128	NA	0.088	1.4e-03	NA	1.3e-04	NA	1.4e-03
4	GTEx	Skin Sun Exposed Lower leg	0.128	0.0460	0.00200	0.005	NA	0.002	NA	0.003	1.0e-01	NA	2.3e-01	NA	1.7e-01
5	YFS	Blood	0.107	0.0186	0.00000	0.158	0.144	0.158	0.159	0.159	2.3e-49	8.9e-45	2.4e-49	1.4e-49	1.5e-49
6	TCGA	Bladder Urothelial Carcinoma	0.076	0.0380	0.00470	-0.002	0.018	0.015	NA	0.001	5.2e-01	1.1e-02	1.9e-02	NA	2.3e-01
7	TCGA	Testicular Germ Cell Tumors	0.145	0.0680	0.00800	0.058	0.010	0.070	NA	0.091	4.2e-03	1.3e-01	1.8e-03	NA	4.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Diabetes (father)	5.0	6.2	11.7	-1.7	-3.2	-3.3	0.7	3.4	2.5	0.6
Tinnitus: Yes, now most or all of the time	4.8	5.7	9.0	-1.8	-2.5	-2.9	0.4	2.8	3.0	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.2	4.9	11.0	-1.0	-3.2	-3.3	-0.2	2.3	2.0	1.7
Loneliness, isolation	3.4	4.7	7.3	-2.7	-2.6	-1.6	0.2	2.1	2.4	2.5
Financial situation satisfaction	2.9	3.6	7.8	1.6	1.9	1.4	-2.1	-1.5	-2.8	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	2.6	2.8	7.2	-1.6	-2.1	-2.0	0.2	2.7	1.2	0.6
Ever had bowel cancer screening	2.5	2.9	7.6	-0.0	-1.8	-0.9	0.6	1.7	2.8	2.4
Neuroticism (2016)	2.4	3.5	9.7	2.1	2.1	1.5	-3.1	-1.8	-0.1	-0.7
Illnesses of mother	2.4	3.0	5.5	1.1	1.8	2.3	-0.1	-2.4	-1.5	-1.8
Illnesses of father: None of the above (group 1)	2.4	3.0	7.3	0.9	2.7	1.9	-1.1	-2.7	-0.8	0.6
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	10.8	3.3	1.5	1.3	-2.1	-0.6	-0.6	0.6
Gout (self-reported)	2.3	3.2	8.2	0.5	0.8	2.9	-1.0	-2.5	-1.7	-1.8
Family relationship satisfaction	2.2	2.6	4.8	-2.0	0.6	1.2	1.7	-0.7	2.2	2.2
Type 2 Diabetes (T2D) (2012)	2.1	2.4	11.0	-1.8	-0.3	0.3	3.3	0.1	1.2	1.0
Medication: Allopurinol	2.1	2.8	6.8	-0.4	1.3	2.2	0.8	-2.6	-1.9	-1.5
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	5.2	2.3	0.6	0.4	-1.9	-0.5	-1.7	-1.7
Hair/balding pattern: Pattern 3	1.9	2.8	6.2	1.0	2.2	2.2	0.1	-2.5	-1.2	-1.0
Chest pain or discomfort	1.9	2.7	6.6	-1.4	-2.6	-1.5	0.2	1.9	1.9	1.0
Hearing difficulty/problems: Yes	1.8	2.7	7.0	-0.1	-2.5	-2.1	-0.6	2.6	1.0	0.4
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	7.4	-0.9	-2.7	-1.9	-0.2	1.6	1.0	2.2
Ever highly irritable/argumentative for 2 days	1.8	2.2	5.7	-0.1	-2.1	-2.0	-0.7	2.4	0.4	0.3
High blood pressure (siblings)	1.8	2.5	7.1	-0.6	-1.3	-0.7	-2.7	2.0	1.3	1.6
Wears glasses or contact lenses	1.8	2.1	3.8	-1.7	-0.8	-1.4	0.7	1.1	1.9	1.9
Medication: Atenolol	1.7	2.1	9.2	3.0	0.8	0.5	-1.6	-0.8	-0.5	-1.0
Medication: Paracetamol	1.7	2.8	7.9	2.5	1.4	0.4	-2.8	-1.5	-1.1	0.2
Forced vital capacity (FVC), Best measure	1.7	6.4	8.0	2.7	2.7	1.9	-2.4	-2.6	-2.8	-2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	5.3	-0.9	-1.7	-2.3	-0.5	2.3	0.8	0.4
Osteoporosis (self-reported)	1.7	2.1	5.8	-0.0	1.6	0.9	1.1	-2.4	1.0	1.8
Number of full brothers	1.6	2.0	4.2	-0.2	-1.9	-2.0	0.8	1.8	-1.3	0.4
Medication: Ibuprofen	1.6	1.9	9.1	3.0	0.9	0.3	-1.7	-0.0	-0.2	0.7
Irritability	1.6	2.8	6.0	-1.8	-2.4	-1.8	0.7	1.6	1.7	1.0
Supplements: Zinc	1.5	1.6	2.9	0.1	-0.5	-1.5	1.5	1.6	1.0	1.7
Hand grip strength (right)	1.5	4.0	10.7	1.7	0.7	-0.3	-2.2	-0.3	-3.0	-3.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.1	3.8	-1.0	-1.7	-2.0	-0.1	1.7	0.6	1.9
Body mass index (BMI)	1.5	6.2	16.5	1.5	-2.4	-3.3	-4.1	1.2	-2.5	-0.8
Had menopause	1.5	1.9	7.4	-0.9	0.4	-0.0	0.9	-0.4	1.9	2.7
Forced vital capacity (FVC)	1.5	5.8	7.6	2.7	2.6	1.8	-2.7	-2.6	-2.3	-2.0
Mean time to correctly identify matches	1.5	2.9	9.9	0.3	2.0	1.9	-0.7	-1.5	0.3	3.2
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	9.2	-1.4	-0.5	-0.8	1.5	1.6	3.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	9.7	2.8	0.7	0.1	-3.1	-0.8	-1.3	-1.5
Guilty feelings	1.5	2.2	3.0	-1.6	-1.6	-1.3	-1.7	1.6	0.4	1.7
Medication: Paracetamol	1.5	2.3	7.0	2.1	1.4	-0.2	-2.6	-1.4	-0.5	0.5
Major Depression (MDD)	1.4	1.7	3.8	-0.2	-1.6	-1.9	-0.5	1.3	1.4	1.2
Lung FVC	1.4	7.2	14.6	2.4	3.8	1.8	-2.3	-3.7	-2.7	-0.7
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	7.0	-2.6	-1.5	-0.9	1.0	0.7	0.6	0.5
Impedance of arm (right)	1.4	6.7	25.1	-2.4	-0.2	-0.2	5.0	1.6	2.8	2.3
Medication: Omeprazole	1.4	1.7	4.0	-1.2	-0.6	-1.7	0.3	1.3	2.0	1.2
Heart disease (mother)	1.4	1.7	3.2	-0.5	-1.7	-1.3	0.2	1.5	1.4	1.8
Arm fat mass (left)	1.4	5.6	13.5	1.5	-2.5	-3.0	-3.7	1.3	-2.4	-0.6
Medication: Lisinopril	1.4	1.8	4.2	-1.3	-2.1	-2.1	-0.8	1.1	-0.5	-0.7
Arm fat-free mass (left)	1.4	7.2	27.9	2.9	0.1	-0.2	-5.3	-1.1	-3.0	-1.9
Reaction Time	1.3	2.4	10.9	0.1	1.3	1.0	-1.4	-1.1	-0.1	3.3
Rheumatoid Arthritis	1.3	1.8	6.6	-0.4	1.5	1.4	-0.2	-0.7	-1.2	-2.6
Average weekly spirits intake	1.3	1.6	3.2	0.4	1.3	1.6	0.7	-1.7	-0.3	-1.8
Arm fat percentage (right)	1.3	5.1	14.2	0.9	-2.6	-3.8	-2.6	2.0	-1.7	0.4
Impedance of arm (left)	1.3	6.2	26.3	-2.3	-0.3	0.4	5.1	1.3	2.7	1.5
Loud music exposure frequency	1.3	1.4	2.8	1.7	1.7	0.9	0.1	-1.1	-1.4	0.4
Arm fat-free mass (right)	1.3	6.7	26.6	2.7	-0.2	-0.2	-5.2	-0.9	-2.6	-2.2
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	4.2	0.8	-1.4	-1.8	0.7	2.1	-0.4	-0.3
Commuting to job workplace: Walk	1.3	1.4	3.4	-1.4	-1.4	-0.6	0.6	1.8	1.1	-0.6
Depressed Affect (Nagel 2018)	1.2	2.5	5.6	-0.9	-2.4	-2.3	-0.3	2.2	0.8	0.5
Depression (Nagel 2018)	1.2	1.8	3.9	-0.4	-1.8	-2.0	-0.4	2.0	0.8	0.7
Ovarian Cancer	1.2	1.7	5.4	0.7	2.3	1.3	0.0	-1.9	-0.5	0.6
Coronary Artery Disease (CAD)	1.2	1.4	6.6	1.1	0.5	-0.4	-2.6	0.1	-1.4	0.2
Impedance of leg (right)	1.2	5.7	22.6	-1.3	0.2	1.4	4.7	0.7	3.4	1.3
Townsend deprivation index at recruitment	1.2	1.7	7.0	0.3	1.3	1.0	0.1	-1.1	-0.9	2.6
Relative age voice broke	1.2	1.8	3.2	0.3	1.7	1.8	0.2	-1.3	-1.6	-1.3
Taking other prescription medications	1.2	1.9	7.7	-0.2	-1.9	-2.8	-0.0	1.0	-1.0	0.4
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	3.7	0.4	0.9	1.2	-0.0	-1.3	-1.9	-1.3
Supplements: Glucosamine	1.2	1.5	5.7	0.5	-0.3	-1.8	-2.4	0.9	0.7	0.0
Financial difficulties in last 2 years	1.2	1.6	3.7	-1.8	-1.0	-1.9	-0.3	1.1	-1.2	-0.1
Trunk fat-free mass	1.2	6.9	24.7	2.7	0.8	0.6	-5.0	-1.7	-2.8	-2.1
Hip circumference	1.2	5.2	17.3	1.6	-2.2	-2.9	-4.2	0.7	-1.6	-0.0
Qualifications: A levels/AS levels or equivalent	1.2	2.7	9.1	2.7	0.1	0.8	-3.0	0.2	-1.1	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	6.8	2.6	1.6	1.3	-2.3	-1.5	-1.8	-2.3
Arm fat mass (right)	1.2	4.9	12.5	1.5	-2.3	-3.0	-3.5	1.1	-2.1	-0.0
Trunk predicted mass	1.2	6.9	24.4	2.7	0.8	0.7	-4.9	-1.8	-2.8	-2.2
Arm predicted mass (right)	1.2	6.0	23.9	2.4	-0.4	-0.2	-4.9	-0.9	-2.7	-2.0
Overall health rating	1.2	2.6	6.5	1.1	-1.0	-2.1	-2.5	1.2	-0.3	2.0
Whole body fat-free mass	1.2	6.7	26.7	2.5	-0.1	-0.3	-5.2	-1.0	-2.9	-2.1
Leg fat-free mass (right)	1.2	6.4	24.7	2.0	-0.8	-1.0	-5.0	-0.4	-3.2	-2.1
Arm fat percentage (left)	1.2	4.8	12.1	1.0	-2.7	-3.5	-2.6	1.9	-1.8	0.0
Whole body water mass	1.2	6.7	27.1	2.5	-0.1	-0.4	-5.2	-0.9	-2.9	-2.1
Leg predicted mass (right)	1.2	6.2	24.1	1.9	-0.9	-1.1	-4.9	-0.3	-3.1	-2.0
Number of self-reported non-cancer illnesses	1.2	2.1	8.5	1.0	-1.3	-1.5	-2.9	0.2	-0.4	1.1
Basal metabolic rate	1.2	6.6	26.5	2.5	-0.5	-0.8	-5.2	-0.6	-3.0	-1.9
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	3.0	-1.3	-0.5	-1.5	0.5	1.3	1.7	1.2
Supplements: Calcium	1.2	1.3	3.7	-1.4	-0.5	-0.4	1.2	0.2	1.3	1.9
Impedance of whole body	1.2	6.1	27.5	-1.8	-0.1	1.0	5.2	1.2	2.9	1.0
Arm predicted mass (left)	1.2	6.0	25.2	2.5	-0.3	-0.6	-5.0	-0.8	-2.6	-1.6
Frequency of depressed mood in last 2 weeks	1.1	1.6	3.7	-0.2	-1.9	-1.3	-0.7	1.5	0.6	1.5
Leg fat-free mass (left)	1.1	5.9	23.2	1.9	-1.3	-1.6	-4.8	0.3	-2.8	-1.4
Fed-up feelings	1.1	2.0	5.8	0.6	-2.4	-1.9	-1.3	1.5	-0.5	0.5
Leg predicted mass (left)	1.1	5.8	22.9	1.9	-1.3	-1.6	-4.8	0.3	-2.7	-1.5
Alcohol usually taken with meals	1.1	1.7	5.2	-0.7	-1.3	-0.9	1.4	1.3	2.3	-0.5
Weight	1.1	5.4	17.1	2.0	-1.6	-2.1	-4.1	0.5	-2.8	-1.4
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	7.4	2.7	1.4	1.5	-2.7	-1.4	-1.4	-2.0
Mouth/teeth dental problems: Dentures	1.1	1.9	9.9	-1.4	0.2	-0.1	3.1	-0.6	-0.7	-0.6
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.7	1.6	-1.4	-1.4	-0.6	1.3	0.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	6.5	2.1	1.1	0.7	-1.3	-0.7	-1.0	-2.5
Long-standing illness, disability or infirmity	1.1	1.7	3.4	1.3	-1.3	-1.5	-1.5	1.1	0.2	1.8
Ever taken oral contraceptive pill	1.1	1.2	3.8	-0.9	-1.1	-2.0	-0.4	0.8	-0.6	1.1
Bipolar Disorder (2011)	1.0	1.0	2.5	-0.1	1.0	1.2	1.4	-1.6	-0.3	-0.0
BMI	1.0	5.5	20.2	2.4	-1.6	-2.4	-4.5	0.6	-1.7	-1.2
Hand grip strength (left)	1.0	2.7	8.3	0.1	1.7	0.1	-1.7	-0.7	-2.2	-2.9
Relative age of first facial hair	1.0	2.1	5.0	0.5	0.9	1.3	-0.2	-1.8	-1.8	-2.2
Vitamin and mineral supplements	1.0	1.3	4.8	0.2	-0.7	-0.6	-1.3	0.6	-2.2	-1.1
High blood pressure	1.0	2.7	11.2	0.0	-1.2	-1.5	-3.3	0.8	0.0	1.8
Impedance of leg (left)	1.0	4.9	19.9	-1.2	1.0	2.3	4.5	-0.2	2.7	0.1
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.3	0.5	-1.7	-1.3	-1.8	1.2	0.0	1.1
Hair/balding pattern: Pattern 2	1.0	1.3	3.5	-1.4	-1.9	-1.0	0.1	1.3	0.2	0.5
Diabetes (self-reported)	1.0	1.5	3.7	1.1	-1.0	-1.9	-1.9	1.0	0.3	0.4
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.3	0.7	1.5	0.9	-0.6	-0.9	-1.5	-1.4
Peak expiratory flow (PEF)	1.0	2.3	6.1	1.5	0.8	1.2	-1.6	-1.3	-1.2	-2.5
Medication for pain relief, constipation, heartburn	1.0	1.8	6.7	-2.6	-1.2	-0.1	1.8	0.6	0.0	-0.6
Migraine (self-reported)	1.0	1.3	2.4	1.3	1.2	0.8	-0.4	-1.4	-1.6	-0.7
Whole body fat mass	1.0	4.0	8.8	1.1	-2.3	-2.8	-3.0	1.3	-1.8	-0.4
Leg fat mass (right)	1.0	4.0	9.8	1.3	-2.4	-2.7	-3.1	1.2	-1.5	-0.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.5	0.7	0.4	1.5	1.1	-0.9	1.9	-0.3
Diabetes diagnosed by doctor	1.0	1.7	4.3	1.0	-1.2	-2.1	-1.9	1.2	0.2	0.3
Medication for cholesterol	1.0	1.5	3.8	-2.0	0.5	1.0	1.6	-0.4	1.6	0.4
Breast cancer (self-reported)	1.0	1.2	4.7	-2.2	-0.4	0.7	1.6	0.1	0.3	0.4
Ever had prostate specific antigen (PSA) test	1.0	1.2	4.2	-0.8	-0.7	-0.5	1.3	0.9	2.0	0.4
Age started oral contraceptive pill	1.0	1.2	6.1	-0.3	-0.4	-0.2	0.4	-0.1	1.4	2.5
Ever depressed for a whole week	1.0	1.2	2.5	-1.6	-1.6	-1.4	0.5	0.2	1.2	-0.2
Leg fat mass (left)	1.0	3.9	10.8	1.3	-2.1	-2.5	-3.3	0.8	-1.7	-0.7
Cardiovascular Disease	0.9	2.8	9.7	0.8	-1.6	-2.2	-3.1	1.4	-0.1	0.4
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.3	1.2	-1.8	-1.6	-1.8	1.2	-0.2	0.4
Number of treatments/medications taken	0.9	1.6	5.9	0.8	-1.2	-2.4	-1.5	0.7	0.4	0.5
Medication: Co-codamol	0.9	1.0	3.2	-1.8	0.6	0.2	1.5	-0.9	0.7	-0.0
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	3.5	0.6	-0.2	-0.8	-1.1	-0.0	-1.0	-1.9
Serious illness, injury or assault to yourself	0.9	1.1	3.8	-0.3	-0.7	-0.6	-1.9	0.1	-1.6	0.8
Heart attack	0.9	1.1	3.9	-1.1	-2.0	-0.5	1.0	1.1	0.5	0.0
Pain all over the body in last month	0.9	0.9	2.7	0.7	0.4	0.7	0.5	-0.6	1.4	1.6
Medication: Ramipril	0.9	1.2	4.2	2.0	-0.7	-0.1	-1.6	0.1	0.9	-0.4
Alcohol intake versus 10 years previously	0.9	1.3	7.1	-0.9	-0.0	-0.2	0.7	0.3	0.8	2.7
Father’s age at death	0.9	1.2	2.4	-1.6	-1.3	-0.9	-0.8	1.3	-0.0	1.1
Depression (self-reported)	0.9	1.0	3.0	1.2	0.7	0.4	-1.7	-1.1	-0.9	-0.0
Medication: Lansoprazole	0.9	1.0	3.8	-0.7	-2.0	-1.4	-0.0	0.4	0.4	0.6
Hair/balding pattern: Pattern 4	0.9	2.2	6.1	-0.6	-1.8	-2.2	0.2	2.5	0.1	-0.9
Glaucoma (self-reported)	0.9	1.0	4.7	0.8	0.7	-0.1	-0.9	-0.6	-0.5	-2.2
Handedness (chirality/laterality): Left-handed	0.9	1.1	4.8	-0.4	-0.2	-0.4	-1.2	1.1	2.2	-0.1
Supplements: Fish oil (including cod liver oil)	0.9	1.1	6.1	-0.1	1.0	-0.0	0.6	-0.5	2.5	0.4
Number of operations (self-reported)	0.9	1.4	3.5	-0.8	-1.9	-1.6	0.4	1.3	0.9	0.5
Average weekly beer plus cider intake	0.9	1.3	3.4	1.5	1.8	1.1	-1.0	-1.0	-0.7	0.2
Unable to work because of sickness or disability	0.9	1.2	5.9	-0.3	0.0	-1.4	0.0	0.3	-0.4	2.4
Vascular/heart problems diagnosed by doctor	0.9	2.5	8.6	0.1	1.9	1.8	2.9	-1.2	0.1	-0.8
Basal cell carcinoma (self-reported)	0.9	1.1	2.9	-0.5	-1.4	-0.7	-0.3	0.7	1.3	1.7
Age at First Birth	0.8	1.2	3.4	0.9	-1.3	-0.5	-1.8	0.9	-1.0	-0.3
Blood Platelet Count	0.8	9.7	12.2	-3.5	-3.1	-2.9	1.8	3.2	3.5	3.5
Trunk fat percentage	0.8	3.0	8.8	0.4	-2.5	-3.0	-1.2	1.8	-1.2	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	5.4	0.9	-1.4	-0.9	-2.3	1.1	-0.4	-1.3
Chronic bronchitis/emphysema (father)	0.8	1.0	4.8	2.2	-0.5	-0.5	-0.8	0.1	-0.7	0.6
Trunk fat mass	0.8	3.4	6.9	1.1	-2.3	-2.6	-2.4	1.3	-1.7	-0.6
Waist circumference	0.8	2.8	8.1	1.5	-1.8	-2.3	-2.8	0.5	-0.8	0.1
Number of incorrect matches in round	0.8	1.3	1.7	1.3	1.2	1.3	1.1	-1.0	0.5	-1.3
Mouth/teeth dental problems	0.8	1.3	4.5	1.6	0.6	0.1	-2.1	-0.3	-0.4	1.2
Illnesses of siblings	0.8	1.1	2.8	0.3	1.1	1.1	0.9	-1.7	-1.1	-0.9
Falls in the last year	0.8	1.1	2.2	1.0	0.0	-0.6	-1.4	-0.8	1.5	1.4
Body fat percentage	0.8	3.3	9.6	0.6	-2.5	-3.1	-1.6	1.8	-1.1	-0.0
Worry too long after embarrassment	0.8	1.3	3.1	-0.1	1.7	1.6	-0.5	-1.8	-0.1	-0.7
Health satisfaction	0.8	1.0	2.7	0.7	-1.4	-1.1	-1.6	0.9	-0.3	0.0
Hypertension (Self-reported)	0.8	2.3	9.7	-0.1	-0.9	-1.3	-3.1	0.7	-0.2	1.8
Qualifications: nursing, teaching	0.8	1.3	4.1	1.0	-1.3	-1.3	-0.6	2.0	0.0	0.1
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.8	-0.9	-1.9	-0.5	0.8	1.2	0.5	0.2
Neuroticism (Nagel 2018)	0.7	1.8	3.6	-0.8	-1.7	-1.7	-0.3	1.9	1.4	0.5
Schizophrenia (2018)	0.7	1.4	2.3	-0.1	-1.5	-1.2	-1.3	1.4	-1.1	-1.0
HbA1C	0.7	0.7	2.5	0.0	-0.3	-1.0	-1.6	0.3	0.3	1.2
Hypothyroidism (self reported)	0.7	1.6	5.2	1.6	0.4	-0.6	-1.0	-0.3	-2.3	-1.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.5	1.2	0.9	0.5	-1.2	-0.9	0.4	1.1
Medication for hormone replacement therapy	0.7	0.7	2.6	-0.0	-0.0	-0.7	-0.2	-0.5	-1.3	-1.6
Average weekly fortified wine intake	0.7	0.8	2.1	0.4	0.9	0.0	0.2	-1.1	-1.3	-1.4
Had other major operations	0.7	0.9	2.3	0.3	-1.1	-1.3	-1.5	0.7	-0.5	-0.2
Leg fat percentage (right)	0.7	2.6	7.2	1.1	-2.2	-2.7	-1.7	1.4	-0.6	-0.0
Number of full sisters	0.7	0.9	2.2	1.5	0.4	-0.3	-0.8	0.7	-1.1	-1.2
Illnesses of father: Heart disease	0.7	0.9	2.3	-0.2	-1.5	-0.6	0.2	1.4	1.1	-0.6
Eye problems/disorders: Cataract	0.7	0.8	2.4	0.8	-0.4	-0.4	-1.5	0.1	-1.6	0.0
Medication: Gliclazide	0.7	0.8	2.0	0.3	1.4	0.5	-1.3	-1.1	-0.1	0.7
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.4	0.9	0.7	1.6	-0.6	-1.5	-0.6	-0.2
Medication: Atorvastatin	0.7	0.8	1.8	0.1	-0.9	-0.6	-1.3	0.9	-1.2	-0.8
Diastolic blood pressure, automated reading	0.7	2.1	5.6	-0.4	-1.8	-2.4	-1.7	1.5	0.5	-0.7
Commuting to job workplace: Cycle	0.7	0.9	4.8	-0.2	0.2	0.3	0.9	0.6	0.1	-2.2
Myopia	0.7	1.0	2.2	-0.3	1.1	1.1	1.5	0.2	1.2	0.6
Triglycerides	0.6	1.1	2.5	1.6	0.9	1.1	-0.5	-1.1	-0.4	-1.0
Ever had hysterectomy (womb removed)	0.6	0.6	2.7	-0.1	-0.2	-0.2	-1.6	-0.3	-0.2	-1.2
Medication: Metformin	0.6	0.9	3.3	0.5	-0.5	-0.8	-1.8	0.8	0.5	1.0
Age when periods started (menarche)	0.6	1.4	5.2	-2.3	-0.6	0.7	1.2	0.4	1.2	0.9
Hearing difficulty/problems with background noise	0.6	1.0	3.0	-0.1	-1.2	-0.8	-1.7	1.3	0.4	-0.0
Medication: Simvastatin	0.6	0.9	4.3	0.5	-0.2	-0.8	0.0	0.1	0.9	2.1
Breastfed as a baby	0.6	0.7	1.3	-1.1	-1.1	-0.2	-0.9	0.4	-1.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.4	-0.9	-1.0	-1.6	0.2	0.4	0.9	0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.4	1.5	0.2	-1.2	-0.6	0.0	-1.9	-1.0
Exposure to tobacco smoke outside home	0.6	0.7	2.4	-0.2	-1.3	-1.6	0.1	0.8	-0.8	0.1
Comparative body size at age 10	0.6	1.8	5.7	-0.6	-0.8	-0.9	-2.4	0.9	-0.8	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.0	0.1	1.4	0.9	-0.6	-0.8	-1.0	-0.1
Medication: Seretide 50 evohaler	0.6	0.7	1.9	-0.6	-1.4	-1.0	-0.1	0.9	1.0	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	2.6	-1.6	0.2	1.0	1.0	0.2	0.5	0.7
Mood swings	0.6	1.2	4.6	-0.6	-2.1	-1.1	0.2	1.2	0.4	-0.2
Mineral and other dietary supplements	0.6	0.8	4.8	0.3	-0.7	0.4	0.1	-0.2	-2.2	-0.5
Smoking status: Current	0.6	0.9	1.5	-0.8	0.9	0.8	1.1	-0.9	-1.2	-0.8
Eye problems/disorders: Glaucoma	0.6	0.7	3.6	-0.3	0.1	-0.2	0.7	-0.6	0.3	-1.9
High cholesterol (Self-reported)	0.6	1.0	3.8	1.9	-0.7	-1.1	-0.5	0.3	-0.4	1.1
Ever smoked	0.6	1.0	2.4	-0.7	1.6	0.7	1.1	-0.9	-0.8	1.0
Leg fat percentage (left)	0.6	2.3	5.2	1.2	-1.7	-2.3	-2.0	0.7	-1.1	-0.9
Crohns Disease (2017)	0.5	1.1	3.8	0.2	-1.5	-1.9	-0.4	0.3	-0.5	-1.1
Irritable Bowel Disease (IBD)	0.5	1.3	2.9	-0.4	-1.5	-1.7	0.4	0.7	0.1	-1.7
Lupus	0.5	0.8	1.8	-1.2	-0.1	-0.9	1.3	0.9	0.5	0.6
Ulcerative Colitis	0.5	0.7	1.3	-0.9	-0.8	-0.9	0.9	0.9	-0.1	-1.2
Smoking Status	0.5	1.2	2.9	-0.7	1.4	0.4	1.3	-1.0	-1.7	-0.6
Diabetes (mother)	0.5	0.6	2.6	0.8	0.4	0.1	-0.8	0.3	-1.6	-0.6
Severe depression (siblings)	0.5	0.5	2.7	0.6	0.1	-0.4	-1.7	0.1	0.5	0.3
Multivitamins +/- minerals	0.5	0.7	2.1	0.9	0.9	0.6	0.6	-0.4	1.5	0.4
High blood pressure (mother)	0.5	0.7	2.8	0.7	-0.2	-0.4	-1.7	0.7	0.7	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.3	0.6	-1.1	-0.4	-0.7	1.0	-0.1	0.8
Asthma	0.5	1.0	3.7	-1.9	-1.4	-0.5	-0.2	-0.1	-0.3	1.1
Prospective memory result	0.5	0.6	1.8	-1.3	-0.4	-0.9	0.4	1.1	0.4	0.4
Blood clot in the leg (DVT)	0.5	0.6	1.8	-1.0	-0.3	-0.3	0.3	0.9	1.3	-0.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.2	-0.5	1.0	1.5	1.0	-0.9	-0.2	0.4
Medication: Ventolin 100micrograms inhaler	0.5	0.6	2.3	-0.7	0.2	-0.1	-1.2	-0.5	-0.2	1.5
Age at first live birth	0.5	0.8	3.6	0.5	0.2	0.5	-1.9	-0.0	-0.2	-1.2
Emphysema/chronic bronchitis	0.5	0.6	1.7	1.0	0.8	-0.3	0.3	0.0	-0.9	-1.3
Supplements: Vitamin C	0.5	0.6	1.3	-1.2	0.1	-0.0	1.1	0.7	1.1	0.2
Asthma (self-reported)	0.5	0.9	2.3	-1.5	-1.2	-0.4	-0.6	-0.3	-0.6	1.3
Average weekly champagne plus white wine intake	0.5	0.6	2.5	0.9	-0.8	0.0	-1.6	0.6	0.1	-0.4
Hearing aid user	0.5	0.5	1.2	1.1	0.1	-0.4	-1.0	0.0	-0.9	-0.5
Illnesses of father: High blood pressure	0.5	0.6	1.5	-1.1	0.5	0.9	-0.2	-1.2	-0.1	-0.6
Cholesterol lowering medication	0.5	0.7	2.6	1.1	-0.5	-0.5	-0.3	0.7	0.2	1.6
Heart disease (siblings)	0.5	0.6	2.9	1.7	0.6	0.3	-0.4	-0.7	0.4	0.3
Alzheimer’s Disease (in father)	0.4	0.5	1.2	0.7	0.7	0.2	-0.1	-1.1	0.3	-1.1
Crohns Disease (2012)	0.4	0.7	1.5	0.3	-0.2	-0.4	-0.9	-0.7	-1.2	-1.2
Mean Putamen Volume	0.4	0.5	1.3	-0.1	-0.3	1.1	-1.1	0.1	-0.4	0.8
Primary Biliary Cirrhosis	0.4	0.5	0.9	-0.9	0.8	-0.4	-0.7	-0.9	-1.0	0.2
Schizophrenia (2014)	0.4	0.8	1.9	0.3	-1.4	-0.7	-1.0	1.2	-0.6	-0.5
Waist Hip Ratio (WHR)	0.4	1.7	5.9	-0.1	-0.5	0.5	2.2	0.2	2.4	0.6
Neuroticism	0.4	1.0	2.4	-0.1	-1.2	-1.0	-0.8	0.7	1.5	1.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.2	0.3	-0.2	-0.6	0.5	0.1	0.5	1.5
Pack years adult smoking proportion	0.4	0.7	1.9	0.5	-1.4	-1.4	0.1	0.8	-0.3	-0.3
Current tobacco smoking	0.4	0.7	1.2	-0.6	0.9	0.6	1.1	-0.7	-1.0	-0.9
Maternal smoking around birth	0.4	0.6	1.3	0.3	-0.6	-1.0	-0.3	0.6	1.0	1.1
Qualifications: CSEs or equivalent	0.4	0.5	2.4	-0.1	-0.1	-0.3	0.0	1.5	0.8	0.7
Past tobacco smoking	0.4	0.8	2.1	0.3	-1.4	-0.1	0.0	1.2	1.1	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	5.3	0.4	-0.8	-0.3	-2.3	0.5	-0.2	-0.7
Lung cancer (father)	0.4	0.5	2.9	0.0	-0.1	-0.5	-0.4	0.2	0.0	1.7
Exposure to tobacco smoke at home	0.4	0.5	1.7	-0.5	0.7	-0.8	-0.4	-0.2	-1.3	0.2
Birth weight of first child	0.4	0.7	1.6	1.0	-0.5	0.6	-1.2	0.0	-0.5	-1.3
Pulse wave reflection index	0.4	0.5	1.5	-0.9	-0.8	-0.6	0.2	1.2	0.2	0.5
Birth weight	0.4	0.9	3.7	-0.8	-1.1	-0.4	-1.9	0.7	-0.3	-0.4
Eye problems/disorders: None of the above	0.4	0.5	2.0	-0.4	0.3	0.6	0.7	-0.1	0.3	1.4
Neck or shoulder pain in last month	0.4	0.6	3.1	-0.4	-0.4	-0.0	-1.8	0.1	-0.7	-0.6
Comparative height size at age 10	0.4	2.4	5.0	1.6	2.1	1.4	-1.4	-2.2	-0.3	0.8
Had major operations	0.4	0.4	1.6	-1.2	-0.1	-0.2	0.8	0.8	0.3	0.3
Leg pain on walking	0.4	0.5	1.1	0.7	-0.4	-0.8	-1.0	0.3	-1.0	-0.0
Friendships satisfaction	0.4	0.5	1.3	-0.1	1.2	0.5	-0.5	-1.2	0.2	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.1	-0.1	-1.5	-0.8	0.4	0.6	0.4	-0.1
Medication: Aspirin	0.4	0.5	1.9	0.9	0.3	-0.4	0.0	0.1	0.8	1.4
Medication: Bendroflumethiazide	0.4	0.6	2.5	-0.3	1.6	0.9	0.1	-0.7	-0.2	0.2
Alcohol drinker status: Never	0.4	0.5	1.7	0.2	-0.3	-0.9	-0.2	-0.5	0.8	1.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.9	-0.6	-0.4	-0.6	-0.3	1.0	1.4	-0.2
Pack years of smoking	0.4	0.6	1.8	0.6	-1.2	-1.3	-0.2	0.6	-0.5	-0.3
Bipolar Disorder or Schizophrenia	0.3	0.8	1.3	0.1	-0.8	-1.0	-1.0	1.1	-0.8	-1.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.9	-1.1	0.0	1.1	0.4	-0.6	-0.9	1.7
Schizophrenia vs Biploar Disorder	0.3	0.4	1.4	0.1	0.2	-0.1	-1.2	0.3	-0.9	-0.4
Ulcerative Colitis (UC)	0.3	0.6	1.7	-0.7	-0.7	-0.4	0.9	0.2	0.6	-1.3
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.8	-1.3	-0.8	0.3	1.2	0.8	0.0	0.4
Body Mass Index (BMI) (2010)	0.3	0.4	2.3	0.2	-0.3	-0.5	-1.5	0.0	-0.4	-0.3
LDL Cholesterol	0.3	0.5	1.3	0.2	1.2	0.2	-0.7	-0.3	-0.9	-1.0
Blood White Count	0.3	2.4	4.7	0.5	2.1	1.9	0.5	-2.2	-0.0	1.9
Respiratory disease	0.3	0.7	1.3	-0.8	-1.1	-0.6	-0.9	0.3	-1.1	0.9
Lung FEV1/FVC ratio	0.3	1.3	3.8	0.8	1.0	1.9	0.8	-1.2	0.6	-1.1
Chronotype (morning person)	0.3	0.7	4.1	-0.3	-0.2	0.4	-0.9	0.0	2.0	-0.0
Sensitivity / hurt feelings	0.3	0.5	1.4	0.3	0.0	-1.0	-1.2	0.2	0.3	-0.8
Systolic blood pressure, automated reading	0.3	0.8	1.9	0.6	0.9	0.7	-1.0	-0.8	-0.8	-1.4
Angina	0.3	0.4	2.0	0.1	-0.7	0.3	0.5	-0.1	-0.5	-1.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.1	0.5	-0.7	-0.3	0.3	-0.8	1.0	0.2
Medication: Levothyroxine sodium	0.3	0.6	1.1	0.6	-0.5	-1.0	-0.1	0.4	-1.0	-1.1
Qualifications: None of the above	0.3	0.7	2.5	-1.6	0.8	0.2	0.5	-1.2	-0.1	0.5
Fluid intelligence score	0.3	0.7	2.1	-1.1	-1.4	-0.0	0.0	0.4	-0.1	1.0
Wheeze or whistling in the chest in last year	0.3	0.5	1.6	-1.0	0.4	-0.1	-0.2	-0.8	-0.3	1.3
Number of children fathered	0.3	0.3	0.7	-0.2	0.2	0.5	0.6	-0.6	0.9	-0.6
Shortness of breath walking on level ground	0.3	0.3	1.2	0.1	-0.4	0.4	1.1	-0.2	0.8	0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.2	0.4	-0.4	0.8	1.1	-0.0	0.3	-0.7
Angina (self-reported)	0.3	0.3	1.2	-0.1	-0.9	0.1	0.5	0.1	-0.3	-1.1
Pulse rate, automated reading	0.3	1.0	2.2	-1.1	-1.5	-1.2	0.7	0.6	0.2	1.1
Alcohol intake frequency.	0.3	0.8	2.1	-0.5	-0.6	-1.2	1.0	0.2	0.4	1.5
Suffer from ‘nerves’	0.3	0.4	1.5	0.1	0.4	0.5	0.9	0.4	1.2	-0.2
Medication: Aspirin	0.3	0.3	0.8	0.9	0.9	0.3	0.1	-0.4	0.3	0.6
Knee pain experienced in last month	0.3	0.4	1.2	1.1	0.3	-0.1	-0.5	-0.4	-0.8	-0.7
Illnesses of siblings: Diabetes	0.3	0.4	1.0	-0.3	-0.5	-0.6	-0.5	0.1	0.8	1.0
Smoking status: Previous	0.3	0.5	0.9	0.4	0.7	-0.7	-0.7	-0.6	-0.9	0.7
Average weekly red wine intake	0.3	0.4	1.3	-0.3	-1.2	-0.2	0.4	0.7	0.9	-0.2
Osteoarthritis (self-reported)	0.3	0.4	1.0	0.8	-0.0	0.0	-0.4	-1.0	0.4	1.0
Mother’s age at death	0.3	0.4	1.4	-0.6	-0.4	-1.2	0.2	0.9	-0.0	0.5
Medication: Blood pressure	0.3	0.5	1.6	0.3	0.1	-0.7	-1.3	0.4	-0.4	1.0
Risk taking	0.3	0.4	1.4	0.7	-1.2	0.0	0.0	0.2	0.3	0.9
Pain experienced in last month	0.3	0.5	1.0	0.5	-0.1	-0.7	1.0	0.8	0.2	1.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	0.5	0.1	0.6	-0.1	0.3	0.6	-0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	0.9	0.5	0.6	0.3	-0.3	-0.2	0.7	-1.0
Fasting Glucose	0.2	0.2	0.7	-0.9	-0.2	-0.0	-0.6	0.5	0.5	-0.1
Heel T-Score	0.2	1.5	7.0	-0.3	-1.0	-0.2	-0.9	1.0	0.6	-2.6
Height	0.2	4.8	12.3	2.7	2.2	3.5	-0.7	-2.0	-1.3	-1.8
Systolic Blood Pressure	0.2	1.0	5.5	0.2	0.3	0.2	-1.0	-0.2	-0.6	-2.4
Allergy or Eczema	0.2	0.4	1.6	-0.1	0.5	0.0	0.4	0.7	0.6	1.3
Hayfever, allergic rhinitis or eczema	0.2	0.5	2.6	-0.2	0.7	0.3	0.3	0.6	-0.0	1.6
Stomach or abdominal pain in last month	0.2	0.2	1.0	1.0	-0.3	0.2	0.1	-0.5	0.3	-0.2
Nervous feelings	0.2	0.3	1.2	0.5	1.1	0.9	0.1	0.1	0.3	0.2
Neuroticism score	0.2	0.5	0.9	-0.1	-0.9	-0.8	-0.9	0.7	0.8	-0.2
Worrier / anxious feelings	0.2	0.4	1.0	-0.3	0.1	-0.5	-0.5	-0.4	0.9	1.0
Number of live births	0.2	0.3	0.8	-0.7	0.4	-0.4	0.6	0.1	-0.6	-0.9
Pulse rate	0.2	0.4	0.7	0.5	-0.0	0.9	0.8	-0.8	0.7	-0.0
Happiness	0.2	0.3	0.8	0.8	-0.1	0.6	0.1	-0.5	-0.0	-0.9
Medication: Cholesterol lowering	0.2	0.4	1.1	0.0	-0.7	-1.1	-0.7	0.7	-0.3	0.1
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	0.7	-0.3	0.3	0.4	-0.0	0.7	0.2
Standing height	0.2	2.1	4.9	1.2	1.3	2.2	-0.8	-1.4	-0.9	-1.9
Length of working week for main job	0.2	0.2	0.9	-0.2	-0.4	0.3	-0.0	-0.2	0.9	-0.3
Tense / ‘highly strung’	0.2	0.4	0.9	0.3	-0.8	-0.3	-0.9	0.3	-0.2	-0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.2	0.6	-0.4	0.1	-0.5	1.1	0.1	0.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.1	1.1	0.0	0.2	-0.8	0.1	-0.2	-0.5
Headache pain in last month	0.2	0.4	1.4	-0.2	-0.5	-0.2	-0.3	0.0	-0.9	-1.2
Pulse wave peak to peak time	0.2	0.2	0.5	-0.7	0.5	0.1	-0.2	-0.2	-0.6	-0.4
Age at last live birth	0.2	0.3	1.1	0.1	0.5	0.3	-1.1	-0.1	0.1	-0.7
Back pain experienced in last month	0.2	0.4	1.1	-0.6	0.1	-0.1	-0.5	0.8	1.0	0.3
Miserableness	0.2	0.3	1.0	0.6	-0.4	-1.0	-0.0	-0.3	-0.4	-0.5
Fractured/broken bones in last 5 years	0.2	0.3	0.9	0.9	-0.1	-0.2	-0.8	-0.3	-0.3	0.6
Alcohol drinker status: Previous	0.2	0.2	0.7	0.1	-0.5	0.5	0.1	-0.2	-0.5	-0.8
Bipolar Disorder (2018)	0.1	0.1	0.3	0.3	0.5	-0.1	0.0	0.1	0.0	-0.4
Worry (Nagel 2018)	0.1	0.2	0.6	0.2	0.6	0.0	-0.6	0.2	0.8	0.1
HDL Cholesterol	0.1	0.2	0.5	-0.7	-0.1	-0.4	-0.4	-0.1	0.6	-0.6
Blood Eosinophil Count	0.1	1.0	2.7	0.1	1.1	0.5	-0.9	-1.1	-1.6	-0.6
Blood Red Count	0.1	1.2	2.6	0.6	0.5	1.3	-1.5	-1.6	-0.8	0.9
Hair Pigment	0.1	2.3	6.5	0.8	-1.7	-2.5	0.5	2.4	0.2	-0.2
Tanning	0.1	1.0	4.0	0.6	0.6	-1.2	-0.3	0.0	-2.0	-0.8
Sitting height	0.1	0.9	2.6	0.2	-1.0	0.4	-1.6	0.7	-1.3	-0.6
Allergy	0.1	0.3	0.9	0.8	-0.2	-0.1	0.3	-0.2	0.3	-0.9
Time employed in main current job	0.1	0.2	0.6	0.5	-0.2	0.1	-0.8	-0.2	-0.3	0.4
Noisy workplace	0.1	0.1	0.2	-0.2	0.4	0.4	-0.5	0.3	0.2	-0.2
Medication: Amlodipine	0.1	0.1	0.3	-0.6	-0.3	-0.2	-0.1	-0.2	0.2	0.0
Qualifications: College or University degree	0.1	0.2	0.8	0.1	-0.5	0.9	-0.2	-0.5	0.1	0.4
Medication: Blood pressure	0.1	0.2	0.8	-0.0	0.3	-0.2	-0.9	-0.3	0.4	-0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	0.1	0.3	0.3	0.3	-0.3	0.2	-0.4
Commuting to job workplace: Public transport	0.1	0.2	0.6	0.3	0.2	0.1	-0.1	-0.8	-0.6	0.3
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

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Trait associations