Best TWAS P=3.72e-13 · Best GWAS P=6.29e-14 conditioned to 0.153
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PIAS1 | 0.25 | 0.06 | enet | 38 | 0.13 | 1.0e-10 | -3.6 | -5.8 | 8.8e-09 | 0.04 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Artery Aorta | PIAS1 | 0.26 | 0.12 | enet | 22 | 0.10 | 3.4e-06 | 6.3 | -6.4 | 1.5e-10 | -0.02 | 0.10 | 0.90 | FALSE |
| 3 | GTEx | Artery Tibial | PIAS1 | 0.14 | 0.02 | enet | 26 | 0.08 | 1.6e-06 | 3.5 | -6.5 | 8.6e-11 | -0.01 | 0.06 | 0.94 | FALSE |
| 4 | GTEx | Brain Putamen basal ganglia | DIS3L | 0.37 | 0.01 | lasso | 4 | 0.02 | 1.4e-01 | -4.0 | -5.3 | 1.4e-07 | -0.04 | 0.05 | 0.11 | TRUE |
| 5 | GTEx | Colon Transverse | IQCH-AS1 | 0.24 | 0.01 | enet | 31 | 0.08 | 1.5e-04 | 6.7 | 5.3 | 1.2e-07 | 0.20 | 0.34 | 0.19 | FALSE |
| 6 | GTEx | Muscle Skeletal | MAP2K5 | 0.08 | 0.03 | lasso | 6 | 0.05 | 1.9e-05 | -4.5 | -5.2 | 2.5e-07 | 0.03 | 0.82 | 0.17 | FALSE |
| 7 | GTEx | Muscle Skeletal | SMAD3 | 0.13 | 0.10 | enet | 8 | 0.10 | 4.2e-10 | 7.2 | 7.3 | 3.7e-13 | 0.91 | 0.01 | 0.99 | TRUE |
| 8 | GTEx | Nerve Tibial | PIAS1 | 0.20 | 0.10 | lasso | 8 | 0.14 | 3.0e-10 | 6.3 | -7.0 | 2.0e-12 | -0.05 | 0.06 | 0.94 | TRUE |
| 9 | The Cancer Genome Atlas | Soft Tissue Sarcoma | LBXCOR1 | 0.07 | 0.03 | blup | 57 | 0.03 | 6.3e-03 | 6.4 | -6.0 | 2.5e-09 | 0.04 | 0.02 | 0.67 | TRUE |