Best TWAS P=4.31e-15 · Best GWAS P=3.69e-19 conditioned to 5.53e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells Transformed fibroblasts | LOXL1-AS1 | 0.28 | 0.09 | lasso | 6 | 0.17 | 1.7e-12 | 4.4 | 6.9 | 5.5e-12 | -0.64 | 0.99 | 0.01 | FALSE |
2 | GTEx | Skin Sun Exposed Lower leg | ISLR | 0.08 | 0.00 | enet | 14 | 0.03 | 2.8e-03 | 3.4 | 6.4 | 1.4e-10 | -0.12 | 0.15 | 0.07 | FALSE |
3 | GTEx | Testis | LOXL1-AS1 | 0.36 | 0.15 | lasso | 10 | 0.13 | 2.4e-06 | -7.3 | -7.8 | 4.3e-15 | 0.60 | 0.51 | 0.08 | TRUE |
4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ISLR2 | 0.02 | 0.02 | lasso | 2 | 0.01 | 5.4e-04 | -7.0 | -7.0 | 2.2e-12 | 0.17 | 0.00 | 0.99 | FALSE |
5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ISLR | 0.02 | 0.02 | lasso | 2 | 0.01 | 6.2e-04 | -7.1 | 7.2 | 7.0e-13 | -0.15 | 0.01 | 0.95 | TRUE |
6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LOC283731 | 0.02 | 0.01 | blup | 15 | 0.01 | 1.9e-03 | -7.0 | -6.4 | 1.3e-10 | 0.20 | 0.00 | 0.88 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | STRA6 | 0.02 | 0.02 | lasso | 2 | 0.02 | 4.5e-05 | -6.3 | 6.2 | 6.0e-10 | -0.09 | 0.09 | 0.52 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC283731 | 0.02 | 0.03 | lasso | 2 | 0.02 | 7.7e-04 | -7.0 | -7.0 | 1.8e-12 | 0.17 | 0.00 | 0.97 | FALSE |
9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ISLR2 | 0.06 | 0.07 | lasso | 2 | 0.06 | 3.9e-07 | -7.0 | -7.0 | 1.8e-12 | 0.17 | 0.00 | 1.00 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC283731 | 0.02 | 0.03 | lasso | 3 | 0.02 | 1.5e-03 | -6.9 | -7.0 | 3.6e-12 | 0.17 | 0.00 | 0.95 | FALSE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | ISLR2 | 0.04 | 0.05 | lasso | 2 | 0.04 | 6.5e-05 | -7.0 | -7.0 | 2.2e-12 | 0.16 | 0.00 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC283731 | 0.04 | 0.06 | lasso | 1 | 0.05 | 4.8e-06 | -6.9 | -6.9 | 6.2e-12 | 0.16 | 0.00 | 1.00 | FALSE |