[Hub]/) : Traits : Impedance of whole body : ← →

chr15:76,398,193-78,806,023

Best TWAS P=5.79e-21 · Best GWAS P=2.61e-17 conditioned to 0.225

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	GTEx	Artery Tibial	TSPAN3	0.14	0.07	lasso	5	0.10	1.6e-08	8.3	-9.4	5.8e-21	-0.83	0.01	0.99	TRUE
18	GTEx	Brain Hypothalamus	RP11-797A18.4	0.21	0.18	lasso	7	0.22	7.6e-06	8.1	-8.6	9.3e-18	-0.93	0.01	0.98	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TSPAN3	0.05	0.01	blup	43	0.01	1.5e-02	7.9	-8.5	2.0e-17	-0.79	0.01	0.47	FALSE
25	GTEx	Cells Transformed fibroblasts	RP11-797A18.4	0.12	0.11	lasso	8	0.12	4.0e-09	7.9	-8.5	2.1e-17	-0.87	0.02	0.98	FALSE
29	GTEx	Esophagus Muscularis	RP11-797A18.4	0.07	0.09	lasso	3	0.09	6.3e-06	8.3	-8.3	7.1e-17	-0.88	0.01	0.99	FALSE
36	GTEx	Nerve Tibial	TSPAN3	0.13	0.08	lasso	2	0.07	9.0e-06	8.3	-8.3	7.8e-17	-0.86	0.01	0.99	FALSE
31	GTEx	Heart Left Ventricle	RP11-797A18.4	0.16	0.09	enet	12	0.08	3.3e-05	8.3	-8.2	2.0e-16	-0.85	0.01	0.98	FALSE
42	GTEx	Testis	PSTPIP1	0.10	0.03	lasso	3	0.02	4.1e-02	8.1	-8.1	5.2e-16	-0.82	0.03	0.87	FALSE
19	GTEx	Brain Nucleus accumbens basal ganglia	RP11-797A18.4	0.12	0.22	lasso	1	0.17	3.1e-05	8.0	-8.0	1.0e-15	-0.82	0.04	0.80	FALSE
41	GTEx	Skin Sun Exposed Lower leg	RP11-797A18.4	0.16	0.08	enet	23	0.09	1.3e-07	8.0	-7.8	4.6e-15	-0.83	0.03	0.97	FALSE
40	GTEx	Skin Sun Exposed Lower leg	TSPAN3	0.11	0.03	enet	8	0.10	2.5e-08	-6.7	-7.8	7.4e-15	-0.69	0.06	0.90	FALSE
16	GTEx	Brain Frontal Cortex BA9	RP11-797A18.4	0.35	0.35	lasso	5	0.35	4.8e-10	8.0	-7.8	8.5e-15	-0.80	0.06	0.94	FALSE
15	GTEx	Brain Cortex	RP11-797A18.4	0.47	0.28	enet	14	0.34	3.3e-10	8.1	-7.7	1.7e-14	-0.81	0.02	0.98	FALSE
3	GTEx	Adipose Visceral Omentum	RP11-797A18.4	0.06	0.05	lasso	3	0.06	4.1e-04	8.0	-7.6	4.0e-14	-0.79	0.03	0.90	FALSE
11	GTEx	Brain Caudate basal ganglia	RP11-797A18.4	0.21	0.14	lasso	5	0.12	2.9e-04	8.0	-7.5	8.7e-14	-0.82	0.06	0.87	FALSE
35	GTEx	Muscle Skeletal	RP11-797A18.4	0.14	0.14	lasso	6	0.18	6.6e-17	7.9	-7.5	9.6e-14	-0.81	0.05	0.95	FALSE
24	GTEx	Cells Transformed fibroblasts	TSPAN3	0.17	0.16	lasso	3	0.17	1.7e-12	8.3	-7.4	1.0e-13	-0.85	0.00	1.00	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	TSPAN3	0.26	0.14	lasso	6	0.12	8.2e-05	-6.7	-7.4	1.3e-13	-0.54	0.12	0.34	FALSE
39	GTEx	Skin Not Sun Exposed Suprapubic	RP11-797A18.4	0.19	0.10	enet	31	0.15	8.0e-09	8.1	-7.4	1.6e-13	-0.72	0.07	0.93	FALSE
49	NTR	Blood	TSPAN3	0.07	0.08	lasso	9	0.09	5.1e-27	8.0	-7.3	2.0e-13	-0.80	0.09	0.91	FALSE
51	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TSPAN3	0.05	0.00	enet	7	0.02	9.7e-03	8.0	-7.2	5.2e-13	-0.71	0.01	0.75	FALSE
10	GTEx	Brain Caudate basal ganglia	PSTPIP1	0.22	0.12	lasso	9	0.13	1.4e-04	8.1	7.2	5.5e-13	0.80	0.02	0.92	FALSE
33	GTEx	Lung	RP11-797A18.4	0.19	0.09	enet	21	0.17	3.5e-13	8.0	-7.2	6.8e-13	-0.68	0.05	0.95	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	TSPAN3	0.03	0.01	blup	43	0.01	8.2e-03	4.9	-7.2	8.6e-13	-0.68	0.04	0.64	FALSE
6	GTEx	Artery Coronary	RP11-797A18.3	0.12	0.03	lasso	10	0.01	1.1e-01	-3.8	-7.1	9.2e-13	-0.81	0.04	0.50	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	PSTPIP1	0.13	0.04	enet	13	0.10	4.0e-04	5.6	-7.1	1.5e-12	-0.73	0.07	0.78	FALSE
43	GTEx	Testis	TSPAN3	0.19	0.05	lasso	7	0.06	1.6e-03	8.0	-7.1	1.6e-12	-0.73	0.03	0.90	FALSE
9	GTEx	Artery Tibial	RP11-797A18.4	0.14	0.03	enet	25	0.09	2.3e-07	8.0	-7.0	2.1e-12	-0.67	0.03	0.97	FALSE
26	GTEx	Cells Transformed fibroblasts	RP11-797A18.6	0.07	0.06	lasso	4	0.06	2.2e-05	8.3	-7.0	2.4e-12	-0.77	0.01	0.99	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	RP11-797A18.4	0.14	0.11	enet	10	0.15	6.0e-06	5.5	-7.0	2.5e-12	-0.82	0.02	0.97	FALSE
20	GTEx	Brain Putamen basal ganglia	RP11-797A18.4	0.27	0.06	lasso	5	0.06	1.7e-02	8.0	-7.0	2.7e-12	-0.77	0.03	0.48	FALSE
50	YFS	Blood	TSPAN3	0.18	0.14	bslmm	256	0.18	5.9e-57	-5.0	-7.0	3.3e-12	-0.54	1.00	0.00	FALSE
46	GTEx	Whole Blood	TSPAN3	0.05	0.04	lasso	2	0.03	1.8e-03	-6.7	-6.9	6.0e-12	-0.54	0.10	0.41	FALSE
12	GTEx	Brain Cerebellar Hemisphere	RP11-797A18.4	0.14	0.12	enet	10	0.12	6.4e-04	5.5	-6.8	1.3e-11	-0.75	0.04	0.75	FALSE
2	GTEx	Adipose Subcutaneous	RP11-797A18.4	0.19	0.12	lasso	8	0.16	2.1e-13	-3.9	-6.8	1.4e-11	-0.79	0.63	0.37	FALSE
14	GTEx	Brain Cerebellum	RP11-797A18.4	0.29	0.20	lasso	9	0.25	4.0e-08	8.1	-6.8	1.4e-11	-0.78	0.04	0.94	FALSE
38	GTEx	Skin Not Sun Exposed Suprapubic	RP11-797A18.3	0.15	0.08	lasso	3	0.09	1.2e-05	-3.7	-6.8	1.4e-11	-0.79	0.10	0.86	FALSE
27	GTEx	Colon Transverse	RP11-797A18.4	0.15	0.03	lasso	5	0.05	3.1e-03	-3.8	-6.6	3.6e-11	-0.78	0.04	0.88	FALSE
32	GTEx	Lung	RP11-797A18.3	0.05	0.03	enet	8	0.04	3.4e-04	-3.7	-6.6	5.5e-11	-0.79	0.06	0.86	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	RP11-797A18.4	0.16	0.08	lasso	6	0.14	2.7e-05	-3.7	-6.3	2.5e-10	-0.77	0.07	0.85	FALSE
4	GTEx	Adrenal Gland	RP11-797A18.4	0.13	0.04	enet	18	0.11	1.1e-04	-3.7	-6.2	5.2e-10	-0.76	0.04	0.82	FALSE
34	GTEx	Muscle Skeletal	HMG20A	0.04	0.00	lasso	4	0.01	7.2e-02	5.6	-6.2	5.7e-10	-0.55	0.03	0.73	FALSE
30	GTEx	Heart Atrial Appendage	RP11-797A18.4	0.16	0.06	enet	17	0.11	1.5e-05	8.0	-6.1	8.0e-10	-0.73	0.06	0.92	FALSE
13	GTEx	Brain Cerebellum	HMG20A	0.14	0.03	enet	7	0.10	6.4e-04	8.1	-6.1	1.4e-09	-0.73	0.04	0.76	FALSE
45	GTEx	Uterus	RP11-797A18.4	0.26	0.11	enet	12	0.16	4.0e-04	8.5	-6.0	1.5e-09	-0.84	0.01	0.88	FALSE
8	GTEx	Artery Tibial	LINGO1	0.08	0.04	lasso	5	0.03	2.7e-03	-5.8	-6.0	1.9e-09	-0.46	0.24	0.18	FALSE
5	GTEx	Artery Aorta	RP11-797A18.4	0.13	0.11	enet	17	0.12	2.3e-07	-3.8	-6.0	2.4e-09	-0.76	0.16	0.83	FALSE
48	METSIM	Adipose	PSTPIP1	0.04	0.04	lasso	3	0.04	2.3e-06	-4.9	-5.8	6.7e-09	-0.55	0.62	0.37	FALSE
37	GTEx	Ovary	RP11-797A18.6	0.21	0.04	enet	15	0.13	3.7e-04	8.3	-5.8	6.9e-09	-0.78	0.03	0.69	FALSE
17	GTEx	Brain Hippocampus	PEAK1	0.23	0.05	lasso	6	0.02	9.9e-02	-5.7	5.7	1.4e-08	0.40	0.13	0.09	FALSE
55	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SCAPER	0.06	0.00	enet	5	0.00	3.4e-01	5.8	-5.7	1.6e-08	-0.32	0.01	0.55	FALSE
47	GTEx	Whole Blood	RP11-797A18.6	0.04	0.02	enet	8	0.03	4.9e-04	-3.8	-5.5	3.7e-08	-0.75	0.15	0.38	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	SCAPER	0.05	0.02	blup	151	0.02	2.3e-03	4.3	-5.5	4.4e-08	-0.26	0.03	0.73	FALSE
1	GTEx	Adipose Subcutaneous	PEAK1	0.05	0.03	lasso	5	0.02	8.6e-03	-5.7	5.5	5.1e-08	0.37	0.30	0.03	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	SCAPER	0.05	0.02	lasso	3	0.02	7.5e-05	4.8	-5.4	7.2e-08	-0.36	0.00	0.99	FALSE
44	GTEx	Testis	RP11-797A18.6	0.09	-0.01	enet	14	0.01	1.7e-01	-2.9	-5.2	1.9e-07	-0.48	0.06	0.33	FALSE