TWAS hub - ISLR2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0196	0.0112	1.0e-03	0.020	0.011	0.010	NA	0.014	4.7e-05	2.2e-03	2.8e-03	NA	5.4e-04
2	TCGA	Prostate Adenocarcinoma	0.0628	0.0276	2.0e-06	0.072	0.051	0.056	NA	0.063	4.9e-08	4.7e-06	1.6e-06	NA	3.9e-07
3	TCGA	Thyroid Carcinoma	0.0390	0.0180	4.9e-04	0.047	0.032	0.039	NA	0.041	2.2e-05	4.0e-04	1.0e-04	NA	6.5e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Impedance of arm (right)	14.2	66.3	66.6	-8.2	-8.1	-8.2
Frequency of tiredness / lethargy in last 2 weeks	13.3	21.5	22.0	4.7	4.6	4.7
Impedance of arm (left)	12.1	55.9	56.1	-7.5	-7.5	-7.5
Impedance of whole body	9.7	49.4	49.7	-7.0	-7.0	-7.0
Had major operations	9.5	11.1	11.4	3.3	3.4	3.4
Medication: Paracetamol	9.4	14.6	14.9	3.9	3.8	3.9
Prostate Cancer	7.7	10.9	11.0	3.3	3.3	3.3
Hearing difficulty/problems with background noise	7.6	12.1	12.3	3.4	3.5	3.5
Supplements: Calcium	7.2	7.9	8.0	-2.8	-2.8	-2.8
Had other major operations	7.1	8.7	8.8	2.9	3.0	3.0
Height	6.6	127.0	130.0	-11.4	-11.1	-11.3
Ever depressed for a whole week	6.6	8.1	8.3	2.8	2.9	2.9
Lupus	6.2	9.4	9.9	-3.0	-3.0	-3.2
Hand grip strength (left)	6.1	16.0	16.2	-4.0	-3.9	-4.0
Eye problems/disorders: Glaucoma	6.1	7.2	7.5	2.7	2.6	2.7
Standing height	6.0	59.7	62.4	-7.9	-7.6	-7.7
Heel bone mineral density (BMD) T-score, automated (right)	5.8	13.4	13.7	-3.7	-3.6	-3.7
Number of operations (self-reported)	5.8	8.7	8.9	2.9	3.0	2.9
Osteoarthritis (self-reported)	5.7	7.3	7.9	2.8	2.6	2.7
Neck or shoulder pain in last month	5.5	7.8	8.6	2.9	2.7	2.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	5.5	6.5	6.8	-2.5	-2.5	-2.6
Medication: Paracetamol	5.4	8.9	9.0	3.0	3.0	3.0
Exposure to tobacco smoke outside home	5.4	7.2	7.3	2.7	2.7	2.7
Impedance of leg (right)	4.9	23.6	23.8	-4.9	-4.8	-4.8
Hand grip strength (right)	4.9	13.4	13.5	-3.7	-3.6	-3.7
Ever unenthusiastic/disinterested for a whole week	4.8	5.8	6.2	2.4	2.4	2.5
Impedance of leg (left)	4.5	21.9	22.2	-4.7	-4.7	-4.7
Serious illness, injury or assault to yourself	4.1	5.0	5.6	2.4	2.2	2.2
Comparative height size at age 10	4.1	22.3	23.1	-4.8	-4.7	-4.7
Myopia	4.1	6.0	6.4	-2.5	-2.4	-2.4
Alzheimer’s Disease (in father)	3.9	4.3	4.3	2.0	2.1	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	3.9	6.0	6.2	2.4	2.5	2.5
Peak expiratory flow (PEF)	3.9	8.9	9.2	-3.0	-2.9	-3.0
Body mass index (BMI)	3.8	16.3	16.8	4.1	3.9	4.1
Glaucoma (self-reported)	3.8	4.5	4.6	2.1	2.1	2.1
Heel bone mineral density (BMD) T-score, automated (left)	3.6	8.1	8.3	-2.9	-2.8	-2.9
Sensitivity / hurt feelings	3.5	6.0	6.5	2.4	2.4	2.5
Number of incorrect matches in round	3.4	5.7	5.9	2.3	2.4	2.4
Exposure to tobacco smoke at home	3.4	3.8	3.9	2.0	1.9	2.0
Average weekly beer plus cider intake	3.4	4.9	5.1	-2.3	-2.2	-2.2
Ever taken oral contraceptive pill	3.3	3.7	4.2	2.0	1.8	1.9
Pain experienced in last month	3.2	5.4	5.7	-2.4	-2.3	-2.3
Osteoporosis (self-reported)	3.1	3.9	4.0	-2.0	-1.9	-2.0
Heel T-Score	2.8	22.1	22.6	-4.8	-4.7	-4.7
Number of live births	2.7	3.8	3.8	-1.9	-2.0	-1.9
Alzheimer’s Disease (in mother)	2.6	3.1	3.2	-1.7	-1.8	-1.8
Health satisfaction	2.5	3.2	3.4	1.9	1.7	1.8
Worry too long after embarrassment	2.4	4.1	4.4	1.8	2.1	2.1
Heart disease (mother)	2.4	2.9	3.2	-1.7	-1.7	-1.8
Knee pain experienced in last month	2.4	3.7	3.9	2.0	1.8	2.0
BMI	2.3	13.6	14.1	3.8	3.6	3.7
Mouth/teeth dental problems	2.3	3.5	3.7	-1.8	-1.9	-1.9
Depression (self-reported)	2.3	2.7	3.0	1.5	1.7	1.7
Average weekly champagne plus white wine intake	2.3	3.2	3.3	1.8	1.8	1.7
Heart disease (siblings)	2.3	2.8	2.9	-1.6	-1.7	-1.7
Hair/balding pattern: Pattern 3	2.2	3.2	3.3	-1.8	-1.8	-1.8
Comparative body size at age 10	2.2	6.0	6.4	2.5	2.4	2.5
Financial situation satisfaction	2.2	2.7	2.8	1.7	1.6	1.7
Systolic Blood Pressure	2.1	10.5	10.8	-3.3	-3.2	-3.3
Medication: Co-codamol	2.1	2.4	2.6	1.6	1.5	1.6
Alcohol intake versus 10 years previously	2.1	3.2	3.5	-1.7	-1.8	-1.9
Family relationship satisfaction	2.1	2.6	2.7	-1.6	-1.6	-1.6
Average weekly red wine intake	2.1	3.1	3.2	1.8	1.7	1.8
Leg pain on walking	2.0	2.5	2.8	1.7	1.4	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	2.5	1.6	1.5	1.6
Pain type(s) experienced in last month: Hip pain	2.0	2.5	2.6	1.6	1.5	1.6
Waist circumference	1.9	6.8	7.0	2.6	2.6	2.7
Forced expiratory volume in 1-second (FEV1), predicted	1.9	3.9	3.9	-2.0	-2.0	-2.0
High cholesterol (Self-reported)	1.9	3.4	3.6	-1.8	-1.9	-1.8
Medication: Bendroflumethiazide	1.9	2.9	3.1	1.7	1.8	1.7
Time employed in main current job	1.8	2.1	2.2	1.4	1.4	1.5
Eye problems/disorders: None of the above	1.8	2.1	2.2	-1.5	-1.4	-1.5
Hypothyroidism (self reported)	1.7	3.9	4.0	1.9	2.0	2.0
Maternal smoking around birth	1.7	2.5	2.6	1.6	1.6	1.6
Medication: Ventolin 100micrograms inhaler	1.7	2.2	2.3	1.4	1.5	1.5
Leg fat percentage (left)	1.7	6.2	6.6	2.6	2.4	2.5
Bipolar Disorder or Schizophrenia	1.6	3.8	5.8	0.0	2.4	2.4
Supplements: Zinc	1.6	1.7	1.8	-1.3	-1.3	-1.3
Medication: Levothyroxine sodium	1.6	2.7	2.8	1.6	1.6	1.7
Falls in the last year	1.6	2.2	2.3	1.5	1.4	1.5
Lung cancer (father)	1.6	1.8	2.0	-1.4	-1.3	-1.3
Illnesses of mother	1.6	1.9	2.0	1.3	1.4	1.4
Medication: Aspirin	1.6	2.1	2.1	-1.4	-1.4	-1.5
Illnesses of siblings: Diabetes	1.6	2.0	2.0	-1.4	-1.4	-1.4
Friendships satisfaction	1.6	2.0	2.0	-1.4	-1.4	-1.4
Depressed Affect (Nagel 2018)	1.5	3.1	3.4	1.7	1.8	1.7
Blood Platelet Count	1.5	17.1	17.7	4.2	4.1	4.1
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	2.2	1.5	1.3	1.4
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	2.3	1.5	1.3	1.3
Ever had prostate specific antigen (PSA) test	1.5	1.7	1.9	1.3	1.4	1.3
Alcohol drinker status: Previous	1.5	1.7	1.9	1.3	1.2	1.4
Neuroticism	1.4	3.5	3.7	1.8	1.9	1.9
Diabetes (father)	1.4	1.8	1.8	-1.3	-1.4	-1.4
Medication: Simvastatin	1.4	2.1	2.2	-1.4	-1.5	-1.5
Wheeze or whistling in the chest in last year	1.4	2.5	2.7	1.6	1.6	1.6
Medication: Ibuprofen	1.4	1.6	2.0	1.4	1.2	1.2
Pulse rate, automated reading	1.4	4.4	4.8	2.2	2.0	2.1
Smoking status: Previous	1.4	2.1	2.3	1.3	1.4	1.5
Age at First Birth	1.3	1.9	2.1	-1.5	-1.3	-1.4
Leg fat percentage (right)	1.3	4.8	5.0	2.2	2.1	2.2
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	1.6	1.2	1.2	1.3
Qualifications: nursing, teaching	1.3	2.1	2.2	1.4	1.5	1.4
Back pain experienced in last month	1.3	1.9	2.0	1.4	1.4	1.4
Miserableness	1.3	2.3	2.3	1.5	1.5	1.5
Bipolar Disorder (2018)	1.2	2.0	5.9	0.0	2.4	0.0
Blood Red Count	1.2	11.6	11.9	-3.4	-3.4	-3.5
Forced vital capacity (FVC)	1.2	4.7	5.1	-2.3	-2.1	-2.1
Qualifications: A levels/AS levels or equivalent	1.2	2.7	2.8	1.7	1.7	1.6
Forced vital capacity (FVC), Best measure	1.2	4.5	5.0	-2.2	-2.0	-2.1
Overall health rating	1.2	2.6	2.8	1.7	1.5	1.6
Medication: Aspirin	1.2	1.5	1.5	-1.2	-1.2	-1.2
Medication: Lisinopril	1.2	1.6	1.6	-1.3	-1.3	-1.2
Illnesses of father: High blood pressure	1.2	1.5	1.7	1.2	1.2	1.3
Hearing difficulty/problems: Yes	1.1	1.8	1.9	1.2	1.4	1.4
High blood pressure	1.1	3.1	3.2	-1.7	-1.8	-1.8
Fluid intelligence score	1.1	2.3	2.5	-1.4	-1.5	-1.6
Ever highly irritable/argumentative for 2 days	1.1	1.3	1.5	1.1	1.1	1.2
Breast cancer (self-reported)	1.1	1.3	1.3	1.2	1.1	1.1
Illnesses of father: None of the above (group 1)	1.1	1.3	1.6	-1.3	-1.0	-1.1
Wears glasses or contact lenses	1.1	1.2	1.3	1.1	1.1	1.1
Vascular/heart problems diagnosed by doctor	1.1	3.0	3.1	1.7	1.8	1.8
Neuroticism (Nagel 2018)	1.0	2.2	2.5	1.4	1.6	1.5
Ulcerative Colitis (UC)	1.0	1.8	1.9	-1.4	-1.3	-1.4
Number of treatments/medications taken	1.0	1.8	1.9	1.4	1.3	1.4
Medication: Cholesterol lowering	1.0	1.6	1.6	-1.2	-1.3	-1.2
Medication: Seretide 50 evohaler	1.0	1.1	1.2	-1.1	-1.0	-1.1
Breast Cancer	0.9	2.1	2.3	-1.4	-1.5	-1.4
Schizophrenia (2014)	0.9	2.0	3.0	0.0	1.7	1.7
Type 2 Diabetes (T2D) (2012)	0.9	1.0	1.2	1.1	1.0	1.0
Allergy or Eczema	0.9	2.5	2.8	1.5	1.7	1.6
Average weekly spirits intake	0.9	1.1	1.2	1.1	1.1	1.0
Ever used hormone-replacement therapy (HRT)	0.9	1.1	1.2	-1.0	-1.1	-1.1
Ever had hysterectomy (womb removed)	0.9	1.0	1.1	-1.0	-1.0	-1.0
Relative age voice broke	0.9	1.3	1.4	-1.2	-1.1	-1.2
Sitting height	0.9	6.3	6.9	-2.6	-2.4	-2.5
Birth weight	0.9	2.0	2.2	1.4	1.5	1.4
Medication: Allopurinol	0.9	1.1	1.1	-1.1	-1.1	-1.1
Hypertension (Self-reported)	0.9	2.5	2.6	-1.6	-1.6	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.2	0.9	0.9	1.1
Age started oral contraceptive pill	0.9	1.1	1.2	-1.1	-1.1	-1.1
Multivitamins +/- minerals	0.8	1.1	1.1	1.1	1.0	1.0
Worrier / anxious feelings	0.8	1.5	1.7	1.2	1.2	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	2.7	-1.7	-1.5	-1.6
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.2	0.9	1.0	1.1
Mean time to correctly identify matches	0.8	1.5	1.8	1.3	1.1	1.2
Alcohol intake frequency.	0.8	2.0	2.2	-1.3	-1.5	-1.4
Medication: Gliclazide	0.8	1.0	1.0	-1.0	-1.0	-1.0
Mother’s age at death	0.8	1.0	1.1	-1.1	-1.0	-0.9
Depression (Nagel 2018)	0.7	1.0	1.1	1.0	1.0	1.1
Schizophrenia vs Biploar Disorder	0.7	0.9	2.7	0.0	-1.6	0.0
Reaction Time	0.7	1.4	1.7	1.3	1.1	1.1
Systolic blood pressure, automated reading	0.7	2.1	2.2	-1.4	-1.5	-1.5
Age when periods started (menarche)	0.7	1.7	1.9	1.2	1.4	1.3
Hayfever, allergic rhinitis or eczema	0.7	1.6	1.9	1.1	1.4	1.3
Neuroticism score	0.7	1.5	1.7	1.2	1.2	1.3
Loud music exposure frequency	0.7	0.8	0.9	0.9	0.9	0.9
Loneliness, isolation	0.7	1.0	1.1	-1.0	-1.0	-1.0
Commuting to job workplace: Walk	0.7	0.8	0.9	-1.0	-0.9	-0.9
Triglycerides	0.6	1.0	1.2	-1.0	-1.0	-1.1
Ulcerative Colitis	0.6	0.8	2.5	0.0	1.6	0.0
Smoking Status	0.6	1.3	1.5	1.1	1.1	1.2
Cardiovascular Disease	0.6	1.8	2.0	-1.3	-1.4	-1.3
Alcohol usually taken with meals	0.6	1.0	1.1	1.0	1.0	1.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	2.2	-1.5	-1.4	-1.4
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.1	1.0	1.0	1.0
Medication for pain relief, constipation, heartburn	0.6	1.0	1.1	-1.1	-1.0	-1.0
Ever had bowel cancer screening	0.6	0.7	0.8	-0.9	-0.8	-0.8
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.7	0.6	0.8	0.7
Fed-up feelings	0.5	0.9	1.0	1.0	0.9	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	0.8	0.9	0.8	0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.7	0.7	0.8	0.8
Past tobacco smoking	0.5	0.9	1.1	-0.8	-1.0	-1.0
Father’s age at death	0.5	0.7	0.8	0.9	0.8	0.8
Noisy workplace	0.5	0.6	0.7	0.7	0.8	0.8
Mouth/teeth dental problems: Dentures	0.5	0.8	0.9	0.9	1.0	1.0
Prospective memory result	0.5	0.7	0.7	-0.8	-0.8	-0.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	0.8	0.7	0.9	0.8
Headache pain in last month	0.5	0.9	1.1	1.0	0.9	0.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	0.9	0.9	1.0	0.9
Arm fat-free mass (right)	0.5	2.3	2.4	1.5	1.6	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	0.7	0.8	0.8	0.8
Medication: Omeprazole	0.5	0.6	0.6	-0.7	-0.8	-0.7
Leg fat mass (right)	0.5	1.8	1.9	1.3	1.3	1.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.8	-0.6	-0.9	-0.8
Medication: Blood pressure	0.5	0.9	0.9	-0.9	-1.0	-1.0
Risk taking	0.5	0.7	0.7	0.8	0.9	0.8
Leg fat mass (left)	0.5	2.0	2.1	1.4	1.3	1.5
Schizophrenia (2018)	0.4	0.9	1.4	0.0	1.1	1.2
Ovarian Cancer	0.4	0.5	0.6	-0.6	-0.8	-0.7
LDL Cholesterol	0.4	0.7	0.7	0.8	0.8	0.8
Waist Hip Ratio (WHR)	0.4	1.9	2.0	1.3	1.4	1.4
Chronotype (morning person)	0.4	0.9	1.0	-0.9	-0.9	-1.0
Relative age of first facial hair	0.4	0.9	1.0	-1.0	-0.9	-1.0
Medication for hormone replacement therapy	0.4	0.5	0.5	-0.7	-0.7	-0.7
Medication: Metformin	0.4	0.6	0.6	-0.8	-0.8	-0.7
Severe depression (siblings)	0.4	0.4	0.6	0.8	0.6	0.6
Chronic bronchitis/emphysema (father)	0.4	0.5	0.5	0.7	0.7	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	0.6	0.7	0.7	0.8
High blood pressure (siblings)	0.4	0.6	0.9	0.9	0.7	0.7
Arm predicted mass (right)	0.4	2.0	2.2	1.4	1.5	1.5
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.6	-0.8	-0.6	-0.7
Arm fat percentage (left)	0.4	1.4	1.7	1.3	1.1	1.2
Long-standing illness, disability or infirmity	0.4	0.6	0.8	0.9	0.6	0.8
Medication for cholesterol	0.4	0.7	0.7	0.8	0.8	0.8
Arm fat mass (left)	0.4	1.4	1.5	1.2	1.1	1.2
Pack years of smoking	0.4	0.6	0.6	0.7	0.8	0.8
Body Mass Index (BMI) (2010)	0.3	0.4	0.4	0.5	0.6	0.6
HbA1C	0.3	0.3	0.5	-0.4	-0.7	-0.5
Hair Pigment	0.3	7.3	7.5	2.7	2.7	2.7
Tanning	0.3	3.2	3.4	1.9	1.7	1.8
Trunk fat percentage	0.3	1.1	1.4	-1.0	-1.2	-1.0
Taking other prescription medications	0.3	0.4	0.6	0.6	0.6	0.7
Had menopause	0.3	0.4	0.4	-0.6	-0.7	-0.5
Arm fat mass (right)	0.3	1.3	1.4	1.2	1.1	1.2
Shortness of breath walking on level ground	0.3	0.3	0.4	0.6	0.5	0.6
Number of full sisters	0.3	0.4	0.4	0.6	0.6	0.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.4	-0.6	-0.6	-0.7
Commuting to job workplace: Public transport	0.3	0.4	0.6	0.8	0.5	0.6
Arm fat-free mass (left)	0.3	1.6	1.7	1.2	1.3	1.3
Irritability	0.3	0.5	0.5	0.7	0.6	0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.5	-0.6	-0.7	-0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.5	-0.5	-0.7	-0.7
Crohns Disease (2012)	0.2	0.4	0.7	0.0	0.7	0.8
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.3	0.4	0.5	0.6
Pack years adult smoking proportion	0.2	0.4	0.4	0.6	0.6	0.6
Average weekly fortified wine intake	0.2	0.3	0.4	0.5	0.5	0.6
Qualifications: CSEs or equivalent	0.2	0.2	0.3	-0.5	-0.5	-0.4
Stomach or abdominal pain in last month	0.2	0.2	0.3	0.5	0.4	0.4
Supplements: Glucosamine	0.2	0.2	0.2	0.4	0.5	0.5
Heart attack	0.2	0.2	0.2	-0.5	-0.4	-0.5
Arm fat percentage (right)	0.2	0.6	0.7	0.9	0.7	0.8
Happiness	0.2	0.2	0.3	-0.5	-0.6	-0.5
Breastfed as a baby	0.2	0.2	0.3	0.6	0.3	0.4
Medication: Amlodipine	0.2	0.3	0.4	-0.6	-0.4	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.2	0.4	0.5	0.5
Hearing aid user	0.2	0.3	0.3	0.5	0.5	0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.3	0.5	0.6	0.5
Cholesterol lowering medication	0.2	0.2	0.3	-0.4	-0.5	-0.5
Arm predicted mass (left)	0.2	1.1	1.2	1.0	1.1	1.1
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.3	0.5	0.5	0.4
Worry (Nagel 2018)	0.1	0.2	0.3	0.4	0.6	0.5
Mean Putamen Volume	0.1	0.1	0.2	-0.3	-0.4	-0.3
Fasting Glucose	0.1	0.1	0.1	0.3	0.3	0.3
Rheumatoid Arthritis	0.1	0.1	0.2	0.0	0.5	0.5
Blood White Count	0.1	0.5	0.6	0.8	0.7	0.7
Respiratory disease	0.1	0.2	0.3	0.6	0.4	0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.1	0.3	0.3	0.4
Angina	0.1	0.2	0.2	0.4	0.4	0.5
Diabetes (mother)	0.1	0.1	0.2	0.2	0.3	0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	0.4	0.4	0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.3	0.3	0.3
Medication: Atenolol	0.1	0.2	0.2	0.4	0.4	0.4
High blood pressure (mother)	0.1	0.1	0.1	-0.3	-0.4	-0.3
Trunk fat mass	0.1	0.5	0.6	-0.6	-0.8	-0.6
Allergy	0.1	0.2	0.2	-0.4	-0.5	-0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.3	0.4	0.4
Hip circumference	0.1	0.5	0.6	0.8	0.7	0.7
Pulse rate	0.1	0.2	0.2	0.5	0.4	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.4	0.3	0.4
Length of working week for main job	0.1	0.1	0.1	0.3	0.2	0.2
Birth weight of first child	0.1	0.2	0.2	0.4	0.4	0.5
Pulse wave reflection index	0.1	0.2	0.2	0.4	0.4	0.5
Blood clot in the leg (DVT)	0.1	0.1	0.1	-0.2	-0.4	-0.2
Gout (self-reported)	0.1	0.1	0.1	-0.3	-0.3	-0.3
Age at first live birth	0.1	0.2	0.2	-0.5	-0.4	-0.5
Qualifications: College or University degree	0.1	0.2	0.2	0.5	0.5	0.4
Medication: Blood pressure	0.1	0.1	0.1	-0.3	-0.4	-0.3
Angina (self-reported)	0.1	0.1	0.1	0.2	0.3	0.3
Migraine (self-reported)	0.1	0.2	0.2	-0.4	-0.5	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.4	0.3	0.4
Illnesses of father: Heart disease	0.1	0.2	0.2	-0.3	-0.4	-0.4
Diabetes diagnosed by doctor	0.1	0.2	0.2	-0.5	-0.5	-0.5
Eye problems/disorders: Cataract	0.1	0.1	0.1	-0.2	-0.3	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.2	-0.5	-0.4	-0.4
Mineral and other dietary supplements	0.1	0.2	0.2	-0.4	-0.5	-0.4
Smoking status: Current	0.1	0.1	0.1	0.3	0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.1	0.4	0.3	0.3
Ever smoked	0.1	0.1	0.2	0.3	0.4	0.5
Unable to work because of sickness or disability	0.1	0.2	0.2	-0.4	-0.4	-0.3
Basal cell carcinoma (self-reported)	0.1	0.2	0.2	-0.3	-0.4	-0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.2	-0.4	-0.4	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.2	-0.3	-0.5	-0.4
Alzheimer’s Disease (including proxy)	0.0	0.0	0.0	0.1	0.1	0.1
Crohns Disease (2017)	0.0	0.1	0.1	0.3	0.3	0.3
Irritable Bowel Disease (IBD)	0.0	0.1	0.1	-0.3	-0.3	-0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.1	0.0	0.2
Neuroticism (2016)	0.0	0.0	0.0	-0.1	0.1	0.1
Primary Biliary Cirrhosis	0.0	0.0	0.0	-0.2	-0.1	-0.2
Blood Eosinophil Count	0.0	0.1	0.1	0.3	0.2	0.2
Lung FEV1/FVC ratio	0.0	0.1	0.1	0.3	0.2	0.2
Lung FVC	0.0	0.1	0.1	-0.4	-0.3	-0.2
Vitamin and mineral supplements	0.0	0.0	0.0	0.1	0.1	0.1
Leg fat-free mass (left)	0.0	0.0	0.0	-0.0	0.1	0.0
Townsend deprivation index at recruitment	0.0	0.0	0.1	0.2	0.2	0.2
Current tobacco smoking	0.0	0.0	0.0	0.2	0.1	0.2
Leg predicted mass (left)	0.0	0.0	0.0	-0.0	0.1	0.0
Nervous feelings	0.0	0.1	0.1	0.2	0.2	0.3
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	-0.1	-0.2	-0.1
Qualifications: None of the above	0.0	0.0	0.1	-0.3	-0.2	-0.2
Financial difficulties in last 2 years	0.0	0.1	0.1	-0.2	-0.3	-0.2
Pain all over the body in last month	0.0	0.0	0.1	-0.1	-0.3	-0.2
Diabetes (self-reported)	0.0	0.0	0.0	-0.1	-0.1	-0.0
Medication: Ramipril	0.0	0.0	0.0	0.2	0.2	0.2
Illnesses of siblings	0.0	0.0	0.0	-0.1	0.1	0.1
Weight	0.0	0.2	0.3	0.5	0.5	0.5
Trunk fat-free mass	0.0	0.1	0.1	0.2	0.4	0.3
Asthma	0.0	0.0	0.0	0.1	0.0	0.1
Medication: Lansoprazole	0.0	0.0	0.0	0.1	0.1	0.1
Pulse wave Arterial Stiffness index	0.0	0.0	0.0	-0.2	-0.2	-0.1
Trunk predicted mass	0.0	0.0	0.1	0.1	0.3	0.2
Tense / ‘highly strung’	0.0	0.0	0.0	-0.1	-0.0	-0.1
Hair/balding pattern: Pattern 4	0.0	0.0	0.0	0.1	0.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	0.1	0.2	0.2
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	0.0	-0.0	-0.0
Body fat percentage	0.0	0.0	0.0	0.0	-0.2	-0.0
Number of full brothers	0.0	0.0	0.0	-0.0	0.0	0.1
Number of children fathered	0.0	0.0	0.1	-0.2	-0.2	-0.1
Pulse wave peak to peak time	0.0	0.0	0.0	-0.1	-0.1	-0.2
Emphysema/chronic bronchitis	0.0	0.0	0.0	0.2	0.2	0.2
Whole body fat mass	0.0	0.0	0.0	-0.0	-0.1	-0.0
Suffer from ‘nerves’	0.0	0.0	0.0	0.0	-0.1	0.0
Chest pain or discomfort	0.0	0.1	0.1	0.2	0.3	0.3
Age at last live birth	0.0	0.0	0.1	-0.3	-0.1	-0.1
Supplements: Vitamin C	0.0	0.0	0.1	-0.2	-0.2	-0.2
Whole body fat-free mass	0.0	0.1	0.2	0.3	0.4	0.4
Leg fat-free mass (right)	0.0	0.1	0.1	0.2	0.3	0.3
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.0	0.1	0.0	0.0
Mood swings	0.0	0.0	0.0	-0.1	-0.1	-0.0
Asthma (self-reported)	0.0	0.1	0.1	0.3	0.2	0.2
Whole body water mass	0.0	0.2	0.3	0.4	0.5	0.4
Leg predicted mass (right)	0.0	0.1	0.1	0.3	0.3	0.3
Number of self-reported non-cancer illnesses	0.0	0.0	0.0	-0.2	-0.2	-0.1
Guilty feelings	0.0	0.1	0.1	-0.4	-0.1	-0.2
Medication: Atorvastatin	0.0	0.0	0.0	-0.2	-0.2	-0.1
Alcohol drinker status: Never	0.0	0.0	0.0	0.1	-0.1	-0.1
Basal metabolic rate	0.0	0.2	0.3	0.4	0.5	0.5
Fractured/broken bones in last 5 years	0.0	0.0	0.0	-0.1	-0.1	-0.1
Diastolic blood pressure, automated reading	0.0	0.1	0.1	-0.3	-0.3	-0.3
Commuting to job workplace: Cycle	0.0	0.1	0.1	0.2	0.2	0.3

Hub : Genes

ISLR2

Models

Trait associations