Best TWAS P=2.03e-11 · Best GWAS P=2.51e-09 conditioned to 0.0197
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | TNFSF12 | 0.25 | 0.22 | lasso | 8 | 0.20 | 7.4e-15 | 5.7 | 5.8 | 8.4e-09 | -0.31 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Testis | ZBTB4 | 0.26 | 0.00 | enet | 35 | 0.06 | 1.6e-03 | -4.1 | 5.9 | 3.1e-09 | -0.38 | 0.04 | 0.35 | TRUE |
| 3 | GTEx | Whole Blood | TNFSF12 | 0.09 | 0.03 | enet | 24 | 0.04 | 1.9e-04 | 5.8 | 6.7 | 2.0e-11 | -0.44 | 0.02 | 0.98 | TRUE |
| 4 | METSIM | Adipose | SENP3 | 0.06 | 0.03 | lasso | 3 | 0.02 | 4.9e-04 | 5.7 | -5.3 | 1.3e-07 | 0.17 | 0.03 | 0.95 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | TNFSF12 | 0.10 | 0.04 | lasso | 6 | 0.06 | 9.2e-08 | 5.7 | 6.1 | 1.2e-09 | -0.26 | 0.03 | 0.97 | FALSE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | TNFSF12-TNFSF13 | 0.07 | 0.05 | lasso | 3 | 0.02 | 1.9e-02 | 5.7 | 5.8 | 6.2e-09 | -0.20 | 0.01 | 0.92 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ATP1B2 | 0.04 | 0.02 | blup | 39 | 0.04 | 2.3e-05 | -5.5 | -5.3 | 9.1e-08 | 0.51 | 0.04 | 0.82 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TNFSF12-TNFSF13 | 0.03 | 0.00 | lasso | 4 | 0.01 | 2.9e-02 | 5.7 | 5.4 | 5.1e-08 | -0.45 | 0.01 | 0.58 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | ATP1B2 | 0.04 | 0.01 | blup | 40 | 0.01 | 1.4e-02 | -1.5 | -5.3 | 1.2e-07 | 0.44 | 0.01 | 0.10 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | SHBG | 0.04 | 0.00 | blup | 59 | 0.02 | 4.4e-03 | 5.9 | 5.9 | 2.8e-09 | -0.44 | 0.01 | 0.67 | FALSE |