Best TWAS P=2.62e-16 · Best GWAS P=1.2e-17 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells EBV-transformed lymphocytes | MNT | 0.42 | 0.10 | lasso | 9 | 0.14 | 3.0e-05 | 5.39 | -7.2 | 7.3e-13 | 0.40 | 0.34 | 0.08 | FALSE |
2 | GTEx | Cells EBV-transformed lymphocytes | RP1-59D14.1 | 0.22 | 0.01 | lasso | 4 | 0.01 | 1.3e-01 | 5.39 | -6.6 | 4.4e-11 | 0.39 | 0.07 | 0.11 | TRUE |
3 | GTEx | Muscle Skeletal | METTL16 | 0.19 | 0.06 | enet | 22 | 0.07 | 1.0e-07 | 4.33 | 5.2 | 2.0e-07 | -0.22 | 0.91 | 0.00 | TRUE |
4 | GTEx | Thyroid | WDR81 | 0.15 | 0.03 | lasso | 7 | 0.03 | 1.7e-03 | 5.02 | -5.1 | 2.7e-07 | 0.01 | 0.31 | 0.03 | TRUE |
5 | ROSMAP | Brain Pre-frontal Cortex | MNT | 0.09 | 0.04 | lasso | 5 | 0.06 | 9.5e-09 | 6.30 | -7.2 | 7.4e-13 | 0.35 | 1.00 | 0.00 | FALSE |
6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LOC284009 | 0.02 | 0.01 | blup | 59 | 0.01 | 1.4e-02 | 4.33 | -6.5 | 7.6e-11 | 0.32 | 0.03 | 0.08 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SMG6 | 0.03 | 0.01 | blup | 144 | 0.01 | 4.8e-03 | -6.79 | -8.2 | 2.6e-16 | 0.83 | 0.05 | 0.77 | TRUE |
8 | The Cancer Genome Atlas | Colon Adenocarcinoma | PAFAH1B1 | 0.11 | 0.00 | blup | 61 | 0.04 | 3.6e-03 | -0.76 | 6.3 | 3.0e-10 | -0.06 | 0.01 | 0.33 | TRUE |
9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SMG6 | 0.08 | 0.05 | blup | 144 | 0.07 | 1.3e-04 | -7.86 | -8.2 | 3.4e-16 | 0.83 | 0.07 | 0.89 | TRUE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MNT | 0.03 | 0.01 | enet | 7 | 0.02 | 1.7e-03 | -4.24 | -5.8 | 7.1e-09 | 0.41 | 0.03 | 0.70 | TRUE |
11 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | SRR | 0.16 | 0.03 | blup | 61 | 0.02 | 8.7e-02 | 3.60 | -6.8 | 1.0e-11 | 0.83 | 0.01 | 0.62 | FALSE |
12 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LOC284009 | 0.09 | 0.00 | blup | 59 | 0.00 | 2.3e-01 | 4.33 | -5.9 | 4.0e-09 | 0.26 | 0.01 | 0.26 | TRUE |