TWAS hub - ATP1B2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.0790	0.0320	0.00800	0.008	NA	0.007	NA	0.010	6.5e-02	NA	0.08500	NA	4.8e-02
2	METSIM	Adipose	0.0750	0.0236	0.00014	0.043	0.026	0.019	0.032	0.029	4.3e-07	7.6e-05	0.00064	1.2e-05	3.2e-05
3	TCGA	Bladder Urothelial Carcinoma	0.0600	0.0280	0.00041	0.014	0.023	0.003	NA	0.002	2.2e-02	4.3e-03	0.17000	NA	2.1e-01
4	TCGA	Lung Squamous Cell Carcinoma	0.0436	0.0190	0.00010	0.024	0.040	0.025	NA	0.026	8.9e-04	2.3e-05	0.00071	NA	5.3e-04
5	TCGA	Pancreatic Adenocarcinoma	0.1310	0.0650	0.00670	0.009	0.017	0.001	NA	0.010	1.3e-01	6.3e-02	0.28000	NA	1.1e-01
6	TCGA	Thyroid Carcinoma	0.0400	0.0230	0.00860	0.010	0.014	0.013	NA	0.010	3.3e-02	1.4e-02	0.01900	NA	3.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Basal cell carcinoma (self-reported)	8.7	10.3	15.2	2.2	3.5	3.4	3.8	2.0	3.9
Illnesses of siblings: Diabetes	8.0	9.8	14.7	3.5	2.7	3.8	3.4	3.0	2.0
Impedance of arm (right)	7.7	36.1	43.3	-6.3	-6.0	-5.7	-6.6	-5.3	-6.0
Impedance of arm (left)	7.6	35.3	45.6	-6.8	-6.0	-5.6	-6.5	-4.9	-5.8
Blood Platelet Count	7.2	82.9	102.0	7.4	9.5	8.9	9.2	10.1	9.3
Breastfed as a baby	6.3	7.8	10.0	1.4	3.2	2.9	3.1	2.7	3.1
Family relationship satisfaction	5.6	6.8	9.1	-2.1	-2.8	-2.4	-2.6	-2.8	-3.0
Commuting to job workplace: Public transport	5.3	6.3	10.3	-1.6	-3.0	-2.3	-2.6	-1.9	-3.2
LDL Cholesterol	4.3	6.8	10.3	1.8	2.7	2.7	2.5	3.2	2.4
Alcohol intake frequency.	4.2	9.8	23.3	4.8	2.6	4.1	2.7	2.0	0.7
Impedance of whole body	4.2	21.3	28.6	-4.9	-5.1	-3.9	-5.3	-2.5	-5.3
Had menopause	4.0	5.0	10.1	-1.0	-3.2	-1.9	-2.7	-1.2	-2.5
Mouth/teeth dental problems: Bleeding gums	3.9	5.1	9.4	1.4	2.4	2.9	3.1	1.2	1.9
HDL Cholesterol	3.5	5.9	10.2	-3.2	-1.2	-2.8	-2.1	-3.1	-1.1
Waist Hip Ratio (WHR)	3.5	15.9	30.4	5.5	3.0	3.2	2.7	5.5	2.8
Medication: Co-codamol	3.5	4.0	5.4	-1.6	-2.3	-2.1	-2.1	-2.2	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	3.3	7.6	13.9	2.3	2.0	3.1	2.8	3.7	2.3
Other serious medical condition/disability diagnosed by doctor	3.2	4.2	6.1	1.5	2.5	2.1	2.2	1.4	2.3
Triglycerides	3.1	5.0	8.1	2.0	1.2	2.8	2.4	2.9	1.8
Medication: Cholesterol lowering	3.1	4.8	7.1	0.8	2.7	2.4	2.6	2.5	1.7
Long-standing illness, disability or infirmity	3.0	4.6	9.5	1.7	3.1	1.6	2.2	0.7	2.7
High cholesterol (Self-reported)	2.9	5.2	9.9	0.2	3.1	2.2	2.7	2.0	2.2
Pulse rate	2.8	4.7	6.9	2.1	1.8	2.6	2.4	2.3	1.7
Number of incorrect matches in round	2.6	4.3	5.9	-1.3	-2.2	-2.0	-2.4	-2.2	-2.2
Hayfever/allergic rhinitis (self-reported)	2.6	3.4	5.5	2.3	1.5	2.2	1.7	2.2	0.3
Alcohol intake versus 10 years previously	2.6	3.8	8.7	3.0	0.7	1.6	1.5	2.3	1.9
Heart disease (siblings)	2.4	2.9	6.2	0.3	2.5	1.2	1.6	1.6	2.2
Pulse wave reflection index	2.3	2.9	6.0	-1.6	-0.9	-1.6	-1.4	-2.5	-1.8
Arm predicted mass (right)	2.3	11.6	22.2	3.4	3.1	3.0	4.7	1.6	3.9
Average weekly champagne plus white wine intake	2.3	3.1	9.3	-1.9	-0.4	-1.6	-1.3	-3.1	-1.1
Eye problems/disorders: Glaucoma	2.3	2.7	6.7	0.1	1.3	1.2	1.8	1.8	2.6
Blood White Count	2.2	16.2	26.0	2.6	4.8	3.6	4.3	3.1	5.1
Commuting to job workplace: Walk	2.2	2.4	4.0	-1.6	-1.3	-2.0	-1.9	-1.3	-0.9
Myopia	2.2	3.2	13.0	-3.6	-0.3	-1.7	-1.0	-1.6	-0.1
Arm fat-free mass (right)	2.1	10.7	20.6	3.3	3.0	2.8	4.5	1.3	3.8
Medication: Lisinopril	2.1	2.7	5.4	-1.8	0.5	-2.1	-1.0	-2.3	1.5
High blood pressure	2.0	5.5	18.6	-2.5	0.0	-2.3	-1.7	-4.3	-0.1
Impedance of leg (right)	1.9	9.0	14.3	-2.9	-3.7	-2.0	-3.7	-0.3	-3.8
Qualifications: College or University degree	1.9	6.0	9.0	-2.7	-2.3	-2.1	-2.3	-2.2	-3.0
Medication: Atorvastatin	1.9	2.4	6.6	0.1	1.3	1.4	1.3	2.6	1.5
HbA1C	1.8	2.0	4.9	1.8	-0.4	1.6	0.9	2.2	-0.6
Hearing difficulty/problems with background noise	1.8	2.8	5.9	1.6	2.4	1.3	1.9	1.1	1.5
Commuting to job workplace: Car/motor vehicle	1.8	2.1	3.5	0.9	1.9	1.3	1.7	1.3	1.4
Eye problems/disorders: Cataract	1.8	2.1	8.8	-3.0	-0.6	-1.3	-0.7	-1.3	-0.1
Arm fat-free mass (left)	1.8	9.1	17.7	3.2	2.7	2.4	4.2	0.9	3.5
Ovarian Cancer	1.7	2.2	4.3	0.0	1.7	1.2	1.9	0.9	2.1
Type 2 Diabetes (T2D) (2018)	1.7	3.3	5.7	1.6	1.4	1.6	1.6	2.4	2.0
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.8	11.6	1.5	0.5	2.1	1.6	3.4	1.4
Happiness	1.7	2.1	3.9	-1.4	-1.7	-0.7	-1.1	-1.6	-2.0
Medication: Lansoprazole	1.7	2.0	3.4	0.7	1.6	1.8	1.5	1.6	0.5
Medication: Ventolin 100micrograms inhaler	1.7	2.2	5.3	-0.3	2.3	1.4	1.7	0.7	1.6
Mouth/teeth dental problems: Loose teeth	1.7	2.0	3.6	0.2	1.9	1.2	1.6	0.8	1.9
Diabetes diagnosed by doctor	1.7	2.7	3.3	1.7	1.5	1.8	1.7	1.6	1.5
Ever taken oral contraceptive pill	1.7	1.9	6.2	0.2	0.8	1.2	1.3	2.5	1.1
Arm predicted mass (left)	1.7	8.4	16.2	3.2	2.4	2.1	4.0	0.9	3.6
Impedance of leg (left)	1.6	7.9	13.5	-2.5	-3.3	-2.0	-3.6	-0.3	-3.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.0	3.5	0.1	-1.7	-1.1	-1.5	-1.6	-1.9
Hypertension (Self-reported)	1.6	4.3	15.1	-2.3	0.3	-1.9	-1.3	-3.9	0.2
Ever had hysterectomy (womb removed)	1.5	1.7	3.3	0.8	1.7	1.8	1.5	0.8	0.6
Diabetes (mother)	1.5	2.0	4.5	2.1	1.8	1.4	1.1	1.1	0.4
Medication: Allopurinol	1.5	2.0	3.8	-0.6	1.8	1.9	1.9	0.4	0.7
Suffer from ‘nerves’	1.5	2.4	4.8	-0.6	-1.3	-1.4	-1.5	-2.2	-1.7
Financial situation satisfaction	1.5	1.9	3.3	-1.8	-1.3	-1.0	-1.0	-1.4	-1.4
Vascular/heart problems diagnosed by doctor	1.5	4.2	14.1	2.2	-0.1	2.0	1.4	3.8	0.1
Lung FEV1/FVC ratio	1.4	7.0	14.4	1.5	1.4	3.8	3.0	3.7	0.6
Trunk fat percentage	1.4	5.4	13.8	-2.8	-1.8	-1.9	-1.5	-3.7	-1.4
Chronic bronchitis/emphysema (father)	1.4	1.6	3.6	1.9	1.6	0.3	1.0	0.3	1.6
Trunk fat-free mass	1.4	8.1	16.3	3.0	2.6	1.8	4.0	0.4	3.7
Time employed in main current job	1.4	1.6	4.8	2.2	0.8	1.0	0.6	1.6	0.5
Trunk predicted mass	1.4	8.2	16.4	3.0	2.6	1.8	4.0	0.4	3.7
Medication: Amlodipine	1.4	2.0	3.5	-1.6	1.7	1.1	1.2	-0.3	1.9
Age at first live birth	1.4	2.5	7.7	-0.7	-1.3	-0.9	-1.3	-1.6	-2.8
Medication for pain relief, constipation, heartburn	1.4	2.4	4.3	-1.3	1.0	2.1	1.7	2.0	0.1
Blood Eosinophil Count	1.3	9.9	18.7	-1.3	4.3	4.3	4.3	0.7	1.1
Heel T-Score	1.3	10.7	26.3	2.0	1.4	4.4	3.3	5.1	1.5
Hair/balding pattern: Pattern 2	1.3	1.7	4.4	2.1	1.2	1.3	0.9	1.3	0.4
Tense / ‘highly strung’	1.3	2.2	4.9	-0.8	-0.6	-0.7	-1.4	-2.2	-2.2
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	6.0	-2.5	-1.4	-1.3	-0.8	-0.5	-1.3
Pulse rate, automated reading	1.3	4.1	5.8	2.2	2.0	1.7	1.7	2.4	2.0
Overall health rating	1.3	2.8	5.4	1.5	2.0	1.1	1.7	1.1	2.3
Whole body fat-free mass	1.3	7.4	16.2	2.5	2.5	1.8	4.0	0.0	3.5
Osteoporosis (self-reported)	1.3	1.6	3.8	-1.0	-0.2	-2.0	-1.6	-1.3	-0.7
Whole body water mass	1.3	7.2	16.0	2.5	2.5	1.8	4.0	0.0	3.5
Medication: Paracetamol	1.3	2.1	4.4	0.3	-1.5	-2.1	-1.9	-1.4	-0.8
Primary Biliary Cirrhosis	1.2	1.7	3.0	-1.2	-1.0	-1.7	-1.3	-1.7	-0.3
Relative age of first facial hair	1.2	2.5	6.5	-2.5	-0.3	-1.0	-0.7	-2.3	-1.4
Medication for hormone replacement therapy	1.2	1.4	4.7	-2.2	-0.4	-1.4	-0.7	-0.6	0.8
Serious illness, injury or assault to yourself	1.2	1.4	2.7	1.2	1.6	1.0	1.0	1.1	1.0
Stomach or abdominal pain in last month	1.2	1.4	3.8	-1.9	-1.2	-0.8	-1.1	-0.2	-1.2
Medication: Simvastatin	1.2	1.8	5.4	0.4	2.3	1.0	1.4	0.3	1.6
Hair/balding pattern: Pattern 4	1.2	2.9	8.7	1.1	0.7	1.6	1.5	3.0	1.5
Medication: Paracetamol	1.2	2.0	3.7	0.5	-1.5	-1.9	-1.9	-1.2	-0.8
Gout (self-reported)	1.2	1.6	4.0	-0.3	2.0	1.6	1.6	-0.1	0.7
Leg pain on walking	1.2	1.5	2.2	0.8	1.0	1.2	1.5	1.2	1.5
Qualifications: nursing, teaching	1.2	1.9	3.3	-0.7	-1.6	-1.6	-1.3	-1.0	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	6.3	0.5	1.2	2.5	2.3	1.3	0.1
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.4	-1.4	0.8	-1.1	0.0	-1.9	1.0
Prostate Cancer	1.1	1.5	3.9	2.0	1.4	1.2	1.3	0.2	0.3
Mean Putamen Volume	1.1	1.2	2.0	-0.8	-1.4	-0.8	-1.0	-1.4	-1.1
Systolic blood pressure, automated reading	1.1	3.2	6.5	-2.0	-0.5	-2.0	-2.0	-2.6	-0.3
Eye problems/disorders: Diabetes related eye disease	1.1	1.3	6.8	2.6	-0.3	0.2	-0.1	0.7	0.3
Maternal smoking around birth	1.1	1.5	2.2	1.5	1.3	1.1	1.4	0.8	1.2
Lung cancer (father)	1.1	1.3	2.2	-0.7	-1.2	-1.2	-1.1	-1.5	-1.1
Illnesses of father: Heart disease	1.1	1.6	3.4	0.4	1.9	1.2	1.5	0.9	1.2
Back pain experienced in last month	1.1	1.7	3.2	0.2	1.7	0.9	1.8	-0.0	1.8
Medication: Blood pressure	1.1	2.1	3.8	-1.6	1.1	-1.0	-0.4	-1.9	1.9
Alcohol drinker status: Never	1.1	1.4	4.4	0.7	1.1	2.1	1.2	0.6	-0.5
Diastolic blood pressure, automated reading	1.1	3.3	13.9	-0.4	0.4	-2.1	-1.2	-3.7	-0.1
Smoking Status	1.0	2.4	5.5	-2.4	-1.2	-1.6	-1.0	-1.9	0.2
Illnesses of mother	1.0	1.2	3.5	-0.8	-1.9	-0.5	-0.7	-0.5	-1.4
Exposure to tobacco smoke outside home	1.0	1.3	7.2	2.7	0.8	0.1	-0.1	-0.3	-0.2
Medication: Omeprazole	1.0	1.2	2.5	-1.2	0.1	-1.6	-1.1	-1.5	0.2
Medication: Seretide 50 evohaler	1.0	1.1	3.0	0.8	1.7	0.9	1.3	-0.0	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.8	0.2	1.7	0.6	1.1	0.8	1.4
Mood swings	1.0	1.8	3.9	1.1	1.2	1.6	2.0	0.7	1.1
Basal metabolic rate	1.0	5.5	12.3	2.0	2.1	1.3	3.5	-0.5	3.2
Irritability	1.0	1.7	2.6	1.6	1.5	1.5	1.6	0.5	0.4
Unable to work because of sickness or disability	1.0	1.3	1.9	1.1	1.1	1.2	1.2	1.4	0.8
Worry (Nagel 2018)	0.9	2.0	3.1	-1.7	-1.4	-1.1	-1.2	-1.5	-1.5
Major Depression (MDD)	0.9	1.1	1.9	-1.4	0.4	1.2	1.3	-0.1	-1.1
Lung FVC	0.9	4.3	9.7	0.2	2.4	3.0	3.1	0.2	1.0
Relative age voice broke	0.9	1.4	3.4	-1.8	1.2	-1.0	-0.0	-1.4	0.9
Diabetes (self-reported)	0.9	1.4	2.0	0.9	1.0	1.2	1.3	1.2	1.4
Arm fat percentage (right)	0.9	3.7	11.3	-2.5	-1.0	-1.6	-0.9	-3.4	-0.4
Noisy workplace	0.9	1.1	3.0	0.0	0.7	0.9	1.3	0.8	1.7
Glaucoma (self-reported)	0.9	1.0	3.3	-0.7	0.5	0.5	1.2	0.7	1.8
Body fat percentage	0.9	3.6	9.5	-2.4	-1.4	-1.5	-1.2	-3.1	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	1.8	0.5	1.4	1.3	1.2	1.1	0.2
Leg fat-free mass (right)	0.9	4.7	11.0	1.5	2.1	1.0	3.3	-1.1	3.0
Arm fat percentage (left)	0.9	3.4	9.2	-2.8	-0.9	-1.5	-0.8	-3.0	-0.1
Leg predicted mass (right)	0.9	4.7	10.9	1.5	2.1	1.0	3.3	-1.1	2.9
Depressed Affect (Nagel 2018)	0.8	1.7	2.9	1.4	0.9	1.4	1.7	1.0	1.4
BMI	0.8	4.5	8.9	1.6	2.4	2.3	3.0	-0.3	2.1
Cardiovascular Disease	0.8	2.7	8.1	-0.8	2.9	0.8	1.4	-0.6	2.1
Hearing difficulty/problems: Yes	0.8	1.2	2.2	1.5	1.4	0.3	1.2	0.1	1.3
Medication: Metformin	0.8	1.2	1.8	1.3	1.1	1.0	0.8	1.3	0.7
Age when periods started (menarche)	0.8	1.9	6.3	2.5	1.8	1.0	0.7	0.1	0.8
Multivitamins +/- minerals	0.8	1.0	4.3	0.2	1.0	-0.7	0.0	-2.1	-0.4
Medication: Levothyroxine sodium	0.8	1.4	4.1	-0.5	-0.1	0.5	0.7	2.0	1.8
Waist circumference	0.8	3.0	5.5	1.6	1.8	1.3	2.2	-0.0	2.4
Allergy	0.8	1.9	2.9	-1.1	-1.7	-1.6	-1.6	-1.1	-0.8
Exposure to tobacco smoke at home	0.8	0.9	3.1	1.8	-0.3	0.0	-0.6	-0.6	-1.1
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	3.4	-0.1	-1.8	-1.2	-1.5	-0.4	-1.1
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	4.1	-0.6	-0.0	1.1	1.2	2.0	1.5
Birth weight	0.8	1.8	3.6	0.6	1.9	0.5	1.8	0.1	1.8
Age at last live birth	0.8	1.2	2.0	-1.3	-1.3	-0.9	-1.0	-0.4	-1.4
Supplements: Vitamin C	0.8	1.0	2.3	-1.3	-0.8	-1.5	-0.9	-0.6	-0.3
Knee pain experienced in last month	0.8	1.3	2.4	0.9	1.5	0.8	1.2	0.3	1.5
Medication for cholesterol	0.8	1.2	3.5	1.5	-0.9	0.6	0.1	0.5	-1.9
Supplements: Calcium	0.8	0.9	2.9	-1.1	-0.4	-0.6	-0.8	-0.5	-1.7
Ever used hormone-replacement therapy (HRT)	0.7	0.8	1.8	-1.1	-0.6	-1.3	-1.0	-0.7	0.4
Diabetes (father)	0.7	0.9	1.5	1.1	1.2	1.0	0.8	1.0	0.4
Severe depression (siblings)	0.7	0.7	1.6	0.8	1.3	0.3	0.6	0.3	1.3
Leg fat-free mass (left)	0.7	4.0	9.6	1.1	1.8	0.9	3.1	-1.1	2.8
Current tobacco smoking	0.7	1.2	4.8	-2.2	-0.8	-0.9	-0.5	-0.5	0.6
Fed-up feelings	0.7	1.2	2.4	1.6	0.3	1.5	1.4	0.4	0.6
Leg predicted mass (left)	0.7	4.0	9.7	1.1	1.8	1.0	3.1	-1.2	2.7
Hip circumference	0.7	2.9	13.4	-1.4	-0.6	-1.4	-0.0	-3.7	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.2	-0.9	0.8	-1.1	-0.6	-0.9	0.9
Pulse wave Arterial Stiffness index	0.7	0.8	1.6	0.1	0.9	0.9	1.1	0.6	1.3
Length of working week for main job	0.7	0.8	1.8	-0.0	-1.0	-1.4	-1.3	-0.4	-0.6
Headache pain in last month	0.7	1.2	2.7	1.7	1.4	1.1	1.1	0.2	0.4
Number of full brothers	0.7	0.9	2.3	-1.4	0.7	-0.8	0.1	-0.3	1.5
Pulse wave peak to peak time	0.7	0.8	1.4	-0.0	-0.9	-1.0	-1.0	-0.7	-1.2
Chest pain or discomfort	0.7	0.9	2.9	-0.2	1.0	-0.8	0.0	1.0	1.7
Friendships satisfaction	0.7	0.9	3.2	-1.8	-0.9	-0.1	-0.3	-0.1	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	1.6	1.2	1.3	-0.2	-0.1	-0.7	1.2
Asthma (self-reported)	0.7	1.3	3.9	0.9	2.0	0.3	0.9	0.5	1.5
Osteoarthritis (self-reported)	0.7	0.9	2.9	0.8	1.1	0.2	0.8	0.2	1.7
Medication: Aspirin	0.7	0.9	2.3	-0.1	-0.7	-1.4	-1.5	-0.7	-0.7
Smoking status: Current	0.7	1.1	4.4	-2.1	-0.7	-0.8	-0.5	-0.6	0.5
Number of self-reported non-cancer illnesses	0.7	1.3	3.8	0.3	2.0	1.3	1.3	-0.4	0.2
Illnesses of father: High blood pressure	0.7	0.9	2.8	-0.9	-0.5	-0.8	-0.7	-1.7	-0.5
Average weekly beer plus cider intake	0.7	1.0	2.7	1.0	1.0	0.5	0.9	0.5	1.7
Alcohol drinker status: Previous	0.7	0.7	1.2	1.1	0.8	1.0	1.1	-0.0	0.7
Crohns Disease (2017)	0.6	1.3	3.6	1.9	0.6	0.9	0.7	1.6	0.4
Body Mass Index (BMI) (2010)	0.6	0.8	2.0	-1.4	-0.7	-0.5	-0.1	-1.4	-0.6
Fasting Glucose	0.6	0.7	1.8	0.5	-0.6	-0.5	-1.3	0.1	-1.4
Lupus	0.6	0.9	2.3	-1.3	0.5	-0.8	-0.1	-1.5	0.8
Blood Red Count	0.6	6.1	16.3	2.2	2.5	4.0	2.8	-0.0	-1.1
Average weekly spirits intake	0.6	0.8	3.9	-0.2	0.3	-0.2	0.7	0.4	2.0
Vitamin and mineral supplements	0.6	0.8	2.3	0.9	-0.7	0.9	0.0	1.5	-0.2
Hand grip strength (right)	0.6	1.6	4.0	1.3	1.0	1.3	2.0	1.1	0.4
Body mass index (BMI)	0.6	2.6	5.0	0.8	1.9	1.3	2.1	-0.6	2.2
Trunk fat mass	0.6	2.7	10.6	-1.7	-0.9	-1.3	-0.3	-3.3	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.6	1.3	0.5	1.2	0.7	0.8	-1.1
Illnesses of siblings	0.6	0.9	1.7	-1.0	-1.3	-1.2	-0.9	-0.0	-0.3
Worrier / anxious feelings	0.6	1.2	3.2	-1.8	-1.0	-0.4	-0.4	-0.3	-1.6
Hair/balding pattern: Pattern 3	0.6	0.9	1.7	1.3	0.6	1.2	0.8	1.0	0.3
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	6.2	-0.1	1.2	1.6	2.5	0.6	0.7
Asthma	0.6	1.2	3.7	1.0	1.9	0.2	0.8	0.3	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.4	-1.1	-0.6	-1.1	-0.7	-1.5	-0.5
Eye problems/disorders: None of the above	0.6	0.7	2.6	1.6	-0.4	0.6	-0.1	0.9	-0.6
Medication: Blood pressure	0.6	1.0	4.1	-1.1	0.7	-0.6	-0.1	-2.0	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.0	-1.1	-0.7	-1.4	-0.3	-1.7	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.0	-0.8	0.3	-1.1	-0.8	-1.4	-0.5
Intelligence (Savage-Jansen 2018)	0.5	1.5	3.5	-1.2	-1.3	-0.9	-0.7	-1.9	-1.0
Alzheimer’s Disease (in father)	0.5	0.5	1.3	-0.1	0.4	0.6	0.9	0.8	1.1
Irritable Bowel Disease (IBD)	0.5	1.2	1.6	1.3	1.0	0.9	1.0	1.0	1.3
Reaction Time	0.5	1.0	2.5	1.6	-0.3	1.0	0.2	1.2	-1.1
Hand grip strength (left)	0.5	1.4	3.6	1.3	1.2	0.9	1.9	0.1	0.8
Sensitivity / hurt feelings	0.5	0.8	2.8	-1.7	-0.2	0.2	0.1	-0.9	-1.1
Pack years adult smoking proportion	0.5	0.8	1.1	-0.9	0.6	1.1	1.0	0.7	1.0
Taking other prescription medications	0.5	0.7	1.1	-1.0	1.0	0.2	0.7	-0.9	0.9
Mouth/teeth dental problems	0.5	0.7	1.6	0.0	-0.7	-0.8	-1.0	-0.8	-1.3
Heart attack	0.5	0.6	3.5	-0.1	-0.2	0.1	-0.0	1.9	-0.2
Father’s age at death	0.5	0.7	1.0	0.6	-0.9	-1.0	-0.9	-0.9	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.3	-0.0	1.5	0.3	0.8	-0.7	1.3
Birth weight of first child	0.5	0.9	2.6	1.6	1.0	-0.8	0.3	-1.0	0.6
Peak expiratory flow (PEF)	0.5	1.0	3.0	-0.3	1.1	1.0	1.7	0.8	0.6
Blood clot in the leg (DVT)	0.5	0.7	1.6	-0.7	0.3	1.2	1.2	-0.7	0.2
High blood pressure (siblings)	0.5	0.7	3.0	-0.8	0.7	0.2	0.2	-1.7	-0.1
Number of children fathered	0.5	0.6	2.3	-1.5	-0.6	-0.7	-0.3	0.3	0.0
Mean time to correctly identify matches	0.5	0.9	3.5	1.9	-0.4	0.4	-0.2	0.9	-0.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.1	0.5	-0.3	-0.7	-0.9	-1.4	-0.4
Number of operations (self-reported)	0.5	0.8	2.4	0.1	0.8	0.5	1.0	-1.5	0.6
Commuting to job workplace: Cycle	0.5	0.6	1.8	-0.4	1.3	0.6	0.9	-0.3	0.4
Cholesterol lowering medication	0.5	0.8	2.2	-0.8	1.3	-0.4	0.0	-0.1	1.5
Pain experienced in last month	0.5	0.8	1.9	1.1	-0.6	1.0	0.1	1.4	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.6	-0.5	0.3	1.2	1.3	-0.8	0.3
Depression (Nagel 2018)	0.4	0.5	1.3	1.1	0.8	0.6	0.7	0.1	0.6
Crohns Disease (2012)	0.4	0.6	0.9	0.4	-0.9	-0.8	-0.9	-0.2	-0.9
Height	0.4	8.4	19.5	-1.5	-3.2	-4.2	-1.1	-4.4	-0.5
Systolic Blood Pressure	0.4	2.0	4.7	-2.2	1.5	-1.0	-1.0	-1.6	0.6
Respiratory disease	0.4	0.9	3.3	1.8	1.3	-0.3	0.1	0.0	0.7
Number of treatments/medications taken	0.4	0.7	1.6	-0.8	0.9	-0.6	0.3	-1.2	0.9
High blood pressure (mother)	0.4	0.6	2.5	-0.1	0.8	0.1	0.1	-1.6	0.6
Had other major operations	0.4	0.5	1.4	-0.7	-0.4	-0.8	-0.3	-1.2	0.5
Forced vital capacity (FVC)	0.4	1.4	5.2	-0.3	1.2	1.1	2.3	0.2	0.9
Pain all over the body in last month	0.4	0.4	1.0	-1.0	0.4	-0.7	-0.3	-0.2	0.9
Weight	0.4	1.8	4.0	0.3	0.8	0.1	1.8	-2.0	1.8
Number of live births	0.4	0.5	1.3	-1.1	-0.7	-0.6	-0.8	0.5	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	0.8	-0.1	-0.7	-0.3	-0.9	0.9
Standing height	0.4	4.2	10.7	-1.0	-2.3	-2.6	-0.6	-3.3	-1.0
Comparative body size at age 10	0.4	1.2	3.5	-1.3	-0.9	-0.8	-0.1	-1.9	-0.8
Worry too long after embarrassment	0.4	0.7	1.0	-0.9	-0.6	-0.8	-0.8	-1.0	-0.6
Wheeze or whistling in the chest in last year	0.4	0.7	1.5	-0.4	1.2	-0.8	-0.0	-0.9	1.1
Heart disease (mother)	0.4	0.5	0.9	0.4	0.9	0.5	0.9	0.5	0.8
Whole body fat mass	0.4	1.6	7.3	-1.0	-0.5	-0.8	0.1	-2.7	0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	-1.0	-0.9	0.8	0.4	0.4	-0.7
Medication: Aspirin	0.4	0.5	1.2	0.5	-0.4	-1.0	-1.1	-0.4	-0.2
Smoking status: Previous	0.4	0.6	1.0	-0.2	-0.9	-1.0	-0.8	-1.0	-0.3
Average weekly red wine intake	0.4	0.6	2.2	-1.5	-0.2	-0.3	0.0	1.1	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.8	-0.5	-0.8	-0.5	-0.6	-0.4	-0.9
Mineral and other dietary supplements	0.4	0.5	1.7	-0.2	0.3	0.9	0.5	1.3	0.5
Wears glasses or contact lenses	0.4	0.5	1.0	-0.9	-0.8	-1.0	-0.6	-0.1	-0.2
Medication: Bendroflumethiazide	0.4	0.6	2.7	0.1	0.5	-0.2	0.0	-1.6	0.8
Ever depressed for a whole week	0.4	0.5	1.5	-0.9	-0.3	0.1	0.6	-1.2	-0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.6	3.3	-0.2	-0.1	0.2	0.1	1.8	-0.1
Pack years of smoking	0.4	0.7	1.1	-0.9	0.6	1.0	0.8	0.7	0.8
Alzheimer’s Disease (in mother)	0.3	0.3	1.1	-1.0	0.3	-0.2	0.1	-0.1	0.8
Age at First Birth	0.3	0.5	1.3	-0.3	-0.5	-0.8	-0.6	-0.6	-1.1
Neuroticism (2016)	0.3	0.5	1.6	-0.3	0.1	-0.7	-0.4	-1.3	-0.7
Rheumatoid Arthritis	0.3	0.4	1.2	-0.1	0.7	0.0	0.6	0.4	1.1
Hypothyroidism (self reported)	0.3	0.7	1.6	-1.0	-0.2	0.1	0.3	1.3	1.2
Neuroticism	0.3	0.6	2.7	-0.4	0.3	0.3	0.4	-1.6	-0.7
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.2	0.7	1.0	1.1	0.9	0.8	-0.0
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.0	-0.9	-0.2	0.6	0.0	0.2	-1.0
Alcohol usually taken with meals	0.3	0.6	1.6	-0.7	-0.7	-0.4	-0.5	1.2	-0.6
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.1	0.3	-0.1	0.8	1.1	-0.7	-0.4
Neuroticism score	0.3	0.6	1.0	0.1	0.9	1.0	0.9	-0.8	-0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.0	-1.4	-0.4	-0.4	-0.2	0.2	-1.4
Prospective memory result	0.3	0.4	1.2	1.1	-0.0	0.7	0.1	0.6	-0.5
Arm fat mass (right)	0.3	1.4	6.1	-0.8	0.1	-0.4	0.8	-2.5	1.0
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.9	0.7	0.2	1.0	0.7	0.1	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.7	-0.6	0.3	0.6	0.7	0.8	-0.0
Medication: Ibuprofen	0.3	0.4	1.0	1.0	-0.2	-0.4	-0.1	-0.7	0.8
Number of full sisters	0.3	0.4	1.3	1.1	0.4	0.1	0.1	0.2	0.9
Had major operations	0.3	0.3	1.1	1.1	0.4	-0.0	0.2	-0.7	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.9	0.9	0.7	0.3	-0.1	0.3	-0.7
Loneliness, isolation	0.3	0.4	1.4	0.2	-0.0	0.6	0.2	-0.5	-1.2
Illnesses of father: None of the above (group 1)	0.3	0.3	1.1	-0.3	-0.6	-0.4	-0.6	-0.2	-1.0
Arm fat mass (left)	0.3	1.4	5.0	-1.1	0.2	-0.5	0.7	-2.2	1.1
Miserableness	0.3	0.5	1.4	0.3	0.5	0.7	0.9	0.2	1.2
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.8	0.1	0.6	0.2	0.6	0.9	0.9
Risk taking	0.3	0.5	1.6	-0.4	0.3	-0.9	-0.3	-0.2	1.3
Fractured/broken bones in last 5 years	0.3	0.4	0.9	-0.7	-0.0	-0.7	-0.7	-1.0	-0.0
Bipolar Disorder (2018)	0.2	0.3	1.1	-1.1	-0.5	-0.5	-0.1	0.2	0.1
Schizophrenia (2018)	0.2	0.4	0.7	0.7	0.4	-0.8	-0.4	-0.7	0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	1.0	-0.6	0.3	0.2	0.4	0.4	1.0
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.7	-0.9	-0.2	-0.1	0.0	-1.3	-1.0
Breast Cancer	0.2	0.4	1.4	-0.2	-0.0	-0.7	0.2	0.9	1.2
Chronotype (morning person)	0.2	0.4	0.8	-0.6	-0.5	-0.8	-0.9	-0.3	-0.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.8	0.9	0.4	0.8	0.6	0.3	0.1
Supplements: Zinc	0.2	0.3	0.4	-0.4	-0.6	-0.6	-0.5	-0.7	-0.3
Townsend deprivation index at recruitment	0.2	0.2	0.5	0.7	-0.4	-0.4	-0.7	-0.1	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.5	0.5	0.7	0.1	0.1	-0.7	0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.2	0.7	-0.5	-0.0	-0.5	0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	1.1	1.0	-0.0	-0.2	-0.1	-0.4	0.2
Supplements: Glucosamine	0.2	0.2	0.8	0.5	0.2	-0.4	-0.0	-0.9	-0.4
Medication: Atenolol	0.2	0.3	0.9	-0.2	0.6	0.3	0.3	-0.9	0.5
Sitting height	0.2	1.7	4.5	1.8	0.1	0.6	2.1	-1.2	1.0
Past tobacco smoking	0.2	0.4	0.8	0.7	0.9	0.7	0.4	0.7	-0.0
Qualifications: None of the above	0.2	0.4	1.0	0.7	0.8	-0.3	-0.3	-0.1	1.0
Financial difficulties in last 2 years	0.2	0.3	0.6	0.3	0.5	-0.8	-0.4	-0.8	0.1
Medication: Ramipril	0.2	0.3	0.8	-0.9	0.5	-0.0	0.4	-0.7	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.4	-1.0	0.3	0.9	1.6	-0.2	-0.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	0.1	-0.1	-0.0	-0.3	-0.8	-0.6
Forced vital capacity (FVC), Best measure	0.2	0.9	2.8	-1.1	0.7	0.7	1.7	-0.8	0.0
Shortness of breath walking on level ground	0.2	0.2	0.6	-0.1	0.1	0.7	0.8	0.4	0.3
Emphysema/chronic bronchitis	0.2	0.2	1.2	-0.1	1.1	0.0	0.1	-0.3	0.2
Angina (self-reported)	0.2	0.3	1.6	-1.3	-0.2	-0.1	0.1	0.5	-0.1
Migraine (self-reported)	0.2	0.2	0.5	0.4	0.7	0.6	0.5	0.3	-0.2
Leg fat mass (right)	0.2	0.8	1.5	-0.2	0.5	0.4	1.2	-1.2	1.2
Comparative height size at age 10	0.2	1.3	3.1	1.8	-0.9	1.3	1.5	0.5	-0.1
Ever had bowel cancer screening	0.2	0.2	1.3	-1.1	0.3	-0.2	-0.0	-0.1	0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	0.3	0.5	0.5	0.5	0.6	0.8
Breast cancer (self-reported)	0.2	0.3	0.5	0.7	0.6	0.4	0.1	0.5	-0.6
Medication: Gliclazide	0.2	0.2	1.2	1.1	-0.1	-0.2	-0.3	-0.2	0.2
Guilty feelings	0.2	0.4	1.2	-0.0	0.7	0.5	0.4	-1.1	-0.3
Hearing aid user	0.2	0.2	0.9	-0.9	0.1	-0.3	-0.2	0.3	-0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.6	-0.1	-0.1	0.6	0.7	-0.6	0.2
Leg fat mass (left)	0.2	0.8	2.0	-0.2	0.5	0.1	1.0	-1.4	1.1
Bipolar Disorder or Schizophrenia	0.1	0.2	0.8	-0.1	-0.0	-0.9	-0.3	-0.3	0.5
Schizophrenia vs Biploar Disorder	0.1	0.1	0.6	0.8	0.0	0.3	0.0	-0.3	-0.2
Ulcerative Colitis (UC)	0.1	0.3	1.0	0.2	0.5	0.2	0.4	-0.2	1.0
Schizophrenia (2014)	0.1	0.3	0.7	0.8	-0.0	-0.7	-0.1	-0.6	0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.5	-0.0	0.7	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.1	0.2	0.5	-0.0	0.3	0.6	0.7	0.0	0.0
Allergy or Eczema	0.1	0.3	0.9	0.4	0.1	0.1	-0.0	-0.7	-0.9
Angina	0.1	0.2	0.7	-0.8	0.2	0.2	0.4	0.5	0.0
Average weekly fortified wine intake	0.1	0.1	0.4	-0.1	-0.2	-0.6	-0.3	-0.0	0.3
Qualifications: CSEs or equivalent	0.1	0.2	0.5	0.5	-0.7	0.1	-0.0	0.4	0.5
Nervous feelings	0.1	0.3	0.6	-0.4	-0.7	0.1	-0.5	0.3	-0.8
Fluid intelligence score	0.1	0.1	0.4	-0.0	0.1	0.4	0.2	-0.6	-0.6
Mouth/teeth dental problems: Dentures	0.1	0.1	0.4	0.0	-0.3	-0.2	-0.2	0.7	0.5
Loud music exposure frequency	0.1	0.1	0.2	-0.2	-0.5	0.0	-0.3	0.2	-0.5
Leg fat percentage (right)	0.1	0.3	1.0	-1.0	-0.2	-0.0	-0.0	-0.9	0.3
Health satisfaction	0.1	0.2	0.8	-0.2	-0.1	0.1	0.2	-0.9	-0.3
Neck or shoulder pain in last month	0.1	0.2	0.5	-0.4	-0.1	-0.7	-0.4	-0.4	-0.0
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.6	0.5	0.1	-0.1	0.2	-0.7	-0.0
Ever smoked	0.1	0.2	0.3	-0.5	-0.5	-0.6	-0.3	-0.3	0.1
Leg fat percentage (left)	0.1	0.2	0.8	-0.7	0.0	-0.0	0.1	-0.9	0.3
Age started oral contraceptive pill	0.1	0.2	0.9	0.9	0.4	0.0	-0.0	0.1	-0.0
Neuroticism (Nagel 2018)	0.0	0.1	0.3	-0.6	-0.5	0.1	0.2	-0.2	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.3	2.5	-0.4	-1.6	-1.2	-1.5	-1.0	-0.4
Tanning	0.0	0.3	0.9	-1.0	-0.3	0.6	0.7	-0.0	0.4
Falls in the last year	0.0	0.0	0.1	-0.1	-0.1	-0.0	0.1	-0.3	0.3
Depression (self-reported)	0.0	0.1	0.2	0.5	0.1	-0.1	0.2	0.0	0.1
Mother’s age at death	0.0	0.0	0.0	-0.2	0.1	0.0	0.1	0.1	-0.2

Hub : Genes

ATP1B2

Models

Trait associations