Hub : Genes

C22orf25

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0421	0.0105	2.4e-08	0.042	0.033	0.036	0.04	0.038	2.4e-13	4.9e-11	6.7e-12	8.3e-13	2.3e-12
2	TCGA	Lung Squamous Cell Carcinoma	0.0571	0.0289	2.6e-03	0.000	0.011	0.003	NA	0.001	3.4e-01	1.6e-02	1.3e-01	NA	2.2e-01
3	TCGA	Thyroid Carcinoma	0.1010	0.0350	3.7e-08	0.117	0.092	0.110	NA	0.115	1.9e-11	3.1e-09	8.6e-11	NA	3.0e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	2.7	4.3	6.7	-2.1	1.4	2.6
Bipolar Disorder or Schizophrenia	1.5	3.7	5.6	-2.2	0.9	2.4
Depressed Affect (Nagel 2018)	0.3	0.6	1.0	0.8	-1.0	0.4
Depression (Nagel 2018)	1.7	2.5	5.1	1.1	-2.3	-1.2
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.2	0.1	1.1	-0.0
Neuroticism (Nagel 2018)	1.0	2.3	3.2	1.8	-1.7	-0.8
Schizophrenia (2018)	0.3	0.7	1.2	-1.1	-0.0	1.0
Schizophrenia vs Biploar Disorder	0.1	0.2	0.3	0.3	-0.1	-0.6
Worry (Nagel 2018)	0.1	0.2	0.3	0.6	-0.5	0.2
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.1	-0.5	0.2
Alzheimer’s Disease (in father)	1.0	1.1	2.6	-0.7	1.6	0.3
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	-0.5	0.3	0.3
Crohns Disease (2017)	0.2	0.5	0.9	-0.8	-0.9	0.2
Irritable Bowel Disease (IBD)	0.2	0.6	1.4	-1.2	-0.5	-0.1
Ulcerative Colitis (UC)	0.5	1.0	2.7	-1.6	-0.1	0.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.1	0.3	0.6	-0.5	-0.7	-0.2
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.8	-1.0	0.3	1.3
Breast Cancer	1.1	2.6	4.7	1.7	-0.6	-2.2
Ovarian Cancer	0.9	1.2	2.5	-1.1	0.0	1.6
Prostate Cancer	2.8	3.9	5.9	-2.4	-1.3	2.0
Age at First Birth	0.9	1.4	1.8	1.1	1.3	-1.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.9	1.2	1.0	0.7	-1.1
Coronary Artery Disease (CAD)	0.8	1.0	2.2	-0.7	1.5	0.6
Crohns Disease (2012)	1.0	1.6	2.3	-1.5	-1.5	0.5
Mean Putamen Volume	5.5	6.3	8.0	-2.8	-1.8	2.8
Fasting Glucose	0.4	0.5	1.3	0.2	-1.1	0.2
HbA1C	0.2	0.2	0.6	-0.1	0.8	0.2
HDL Cholesterol	0.3	0.5	0.9	1.0	0.4	-0.7
LDL Cholesterol	0.2	0.3	0.5	0.3	-0.7	-0.5
Lupus	0.1	0.2	0.4	0.0	-0.6	-0.2
Neuroticism (2016)	2.3	3.3	7.9	1.1	-2.8	-0.8
Primary Biliary Cirrhosis	2.1	3.0	7.1	-1.2	2.7	0.7
Rheumatoid Arthritis	0.1	0.1	0.3	0.1	0.6	0.0
Schizophrenia (2014)	0.3	0.6	1.4	-1.2	0.2	0.7
Triglycerides	0.1	0.1	0.4	-0.0	-0.1	0.7
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.7	0.5	0.9	0.5
Ulcerative Colitis	0.5	0.8	2.2	-1.5	-0.4	0.1
Blood Eosinophil Count	1.2	9.5	13.5	3.7	1.3	-3.7
Blood Platelet Count	0.3	3.1	5.8	1.8	0.5	-2.4
Blood Red Count	0.7	6.4	8.5	-2.9	-1.5	2.9
Blood White Count	0.2	1.7	4.7	-0.7	2.2	-0.2
Heel T-Score	1.6	12.8	29.5	-5.4	-0.2	3.0
BMI	2.5	14.4	23.3	4.8	-0.0	-4.5
Height	0.2	3.8	6.4	-2.5	-1.3	1.9
Waist Hip Ratio (WHR)	0.5	2.3	3.2	1.8	1.1	-1.6
Systolic Blood Pressure	1.7	8.4	11.4	3.4	2.5	-2.8
Smoking Status	0.6	1.5	2.3	1.5	-0.6	-1.4
Allergy or Eczema	0.2	0.5	1.1	0.5	-0.4	-1.0
Cardiovascular Disease	1.4	4.5	7.6	2.4	0.2	-2.8
Hypothyroidism (self reported)	0.9	2.0	3.2	-1.8	0.7	1.6
Respiratory disease	0.3	0.6	1.3	-1.2	-0.3	0.6
Type 2 Diabetes (T2D) (2018)	0.9	1.7	2.5	1.1	-1.6	-1.2
Lung FEV1/FVC ratio	0.5	2.6	2.9	1.6	-1.7	-1.5
Lung FVC	0.9	4.4	7.2	2.4	0.5	-2.7
Neuroticism	1.7	4.1	7.7	1.8	-2.8	-1.1
Chronotype (morning person)	0.1	0.3	0.8	-0.9	0.1	-0.2
Hair Pigment	0.0	0.5	0.7	-0.6	-0.7	0.9
Tanning	0.2	2.7	7.5	-0.5	2.7	0.7
Hand grip strength (left)	0.1	0.2	0.4	-0.3	-0.4	-0.6
Number of treatments/medications taken	2.5	4.5	6.8	2.6	0.3	-2.6
Average weekly spirits intake	2.4	3.0	4.0	-2.0	1.6	1.6
Sensitivity / hurt feelings	0.9	1.5	3.5	1.9	-0.3	-0.9
Frequency of depressed mood in last 2 weeks	1.4	2.0	3.9	0.6	-2.0	-1.3
Hearing difficulty/problems: Yes	0.0	0.0	0.0	0.1	0.0	0.2
Relative age of first facial hair	0.3	0.6	1.2	-0.7	-0.3	1.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	3.0	0.2	1.7	-0.3
Ever used hormone-replacement therapy (HRT)	1.0	1.3	3.7	-0.0	-1.9	-0.5
Ever had hysterectomy (womb removed)	1.9	2.2	4.5	-1.2	-2.1	0.8
Systolic blood pressure, automated reading	2.8	8.1	11.4	2.9	3.4	-2.1
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	4.0	0.0	-2.0	-0.1
Angina	0.5	0.7	1.3	-1.2	-0.6	0.5
Medication for hormone replacement therapy	1.3	1.4	2.2	0.5	-1.5	-1.4
Vitamin and mineral supplements	0.1	0.1	0.3	-0.1	-0.5	-0.2
Supplements: Zinc	0.6	0.6	1.3	0.4	1.2	-0.6
Medication: Co-codamol	1.4	1.6	3.8	0.3	-1.9	-0.9
Medication: Metformin	1.3	1.9	4.6	0.7	-2.1	-0.8
Diabetes (father)	0.9	1.2	2.0	0.9	0.8	-1.4
Diabetes (mother)	0.5	0.6	1.3	0.2	-1.1	-0.8
Severe depression (siblings)	0.3	0.3	0.5	0.7	-0.3	-0.5
Pack years adult smoking proportion	0.3	0.4	0.4	0.7	0.5	-0.7
Impedance of leg (right)	3.3	16.1	26.5	-4.6	0.7	5.1
Leg fat-free mass (left)	1.1	6.0	9.7	2.8	-0.5	-3.1
Trunk fat percentage	0.4	1.5	4.2	2.1	0.6	-0.1
Hand grip strength (right)	0.1	0.2	0.3	-0.4	0.6	-0.4
Townsend deprivation index at recruitment	1.4	2.0	3.6	1.5	-0.1	-1.9
Current tobacco smoking	0.2	0.4	0.8	-0.5	0.4	0.9
Average weekly fortified wine intake	0.2	0.2	0.4	-0.6	-0.5	0.4
Maternal smoking around birth	0.0	0.0	0.1	-0.0	-0.4	-0.1
Fed-up feelings	0.1	0.2	0.6	0.8	-0.0	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.6	4.7	1.4	-2.2	-1.0
Relative age voice broke	0.5	0.8	1.1	1.1	0.8	-0.7
Taking other prescription medications	3.7	5.7	9.0	2.7	0.8	-3.0
Age when periods started (menarche)	1.0	2.4	3.6	1.9	1.4	-1.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	-0.3	-0.9	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	3.1	-1.8	-0.3	1.2
Tinnitus: Yes, but not now, but have in the past	2.2	2.3	6.9	0.2	2.6	-0.2
Qualifications: CSEs or equivalent	1.0	1.4	4.0	0.2	-2.0	0.0
Serious illness, injury or assault to yourself	1.0	1.2	2.4	1.0	0.3	-1.6
High blood pressure	1.3	3.7	6.2	2.2	-0.2	-2.5
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.5	0.4	0.7	-0.7
Multivitamins +/- minerals	0.7	0.9	2.2	1.5	0.6	-0.4
Stomach or abdominal pain in last month	0.1	0.1	0.1	0.3	0.2	0.3
Supplements: Glucosamine	1.5	1.9	3.0	1.7	0.6	-1.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.0	1.0	-0.3	-0.6
Medication: Atenolol	0.5	0.6	1.5	0.4	1.2	-0.2
Medication: Levothyroxine sodium	1.7	2.8	5.1	-2.2	1.0	1.6
Sitting height	0.0	0.2	0.4	-0.3	-0.6	-0.1
Chronic bronchitis/emphysema (father)	0.6	0.7	1.8	-0.3	0.5	1.4
High blood pressure (mother)	0.9	1.2	2.1	1.4	-0.4	-1.2
Body mass index (BMI)	1.8	7.7	14.3	3.8	-0.3	-2.9
Impedance of leg (left)	3.0	14.7	24.7	-4.3	0.7	5.0
Leg predicted mass (left)	1.1	5.7	9.1	2.8	-0.5	-3.0
Trunk fat mass	0.5	2.3	6.2	2.5	0.3	-0.9
Waist circumference	2.0	7.2	12.7	3.6	-0.1	-3.0
Number of incorrect matches in round	0.6	1.0	3.1	-0.1	1.8	-0.1
Past tobacco smoking	0.1	0.3	0.6	0.1	0.8	-0.4
Alcohol usually taken with meals	0.4	0.6	1.1	-0.8	0.3	1.0
Nervous feelings	1.8	3.4	5.3	-1.9	1.2	2.3
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	2.5	1.5	-1.6	-1.4
Hearing difficulty/problems with background noise	1.7	2.8	3.1	1.6	-1.7	-1.8
Hair/balding pattern: Pattern 2	2.8	3.6	10.3	-0.1	-3.2	-0.7
Had menopause	0.9	1.2	2.6	0.9	-0.4	-1.6
Had other major operations	0.3	0.3	1.0	0.1	-1.0	0.2
Forced vital capacity (FVC)	0.2	0.8	1.3	0.9	0.4	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	4.3	-2.1	-1.0	1.3
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	3.9	0.2	-2.0	-0.5
Qualifications: None of the above	0.6	1.3	2.7	1.1	0.2	-1.6
Financial difficulties in last 2 years	0.2	0.2	0.3	-0.2	-0.6	0.6
Mouth/teeth dental problems	0.4	0.6	1.8	0.2	1.3	0.1
Heart attack	1.1	1.4	3.6	0.6	1.9	-0.3
Allergy	0.0	0.0	0.1	0.1	-0.1	0.3
Pain all over the body in last month	1.7	1.8	3.5	1.2	-0.7	-1.9
Diabetes (self-reported)	0.7	1.1	2.0	0.7	-1.4	-0.9
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	1.0	0.3	-0.7
Medication: Ramipril	2.1	2.7	3.1	1.8	1.5	-1.7
Medication: Simvastatin	0.6	0.9	1.1	1.1	0.9	-0.9
Fluid intelligence score	0.1	0.1	0.3	0.0	0.6	0.1
Illnesses of siblings	2.6	3.6	5.7	-2.4	0.8	2.1
Neuroticism score	0.6	1.3	2.9	1.7	-1.0	-0.4
Weight	0.8	4.0	7.0	2.6	-0.4	-2.2
Impedance of arm (right)	3.4	15.6	27.6	-4.4	0.6	5.2
Arm fat percentage (right)	0.4	1.7	5.0	2.2	-0.0	-0.4
Trunk fat-free mass	0.5	2.7	5.3	1.1	-1.3	-2.3
Hip circumference	0.9	4.0	6.1	2.5	-1.3	-2.0
Time employed in main current job	0.5	0.5	0.8	0.9	0.5	-0.7
Alcohol intake versus 10 years previously	0.0	0.0	0.0	0.1	0.1	-0.2
Father’s age at death	0.3	0.4	0.6	-0.8	-0.6	0.4
Worrier / anxious feelings	0.2	0.4	0.8	0.9	-0.3	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.3	0.9	-1.2	-0.8
Falls in the last year	2.3	3.2	7.1	-1.5	-2.7	-0.1
Hair/balding pattern: Pattern 3	0.5	0.7	1.1	-1.0	-0.3	1.0
Number of live births	4.6	6.5	8.9	-2.9	-1.4	3.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.4	1.3	0.2	-1.6
Pulse rate	1.0	1.7	3.0	1.4	-0.0	-1.7
Happiness	3.0	3.6	6.0	-2.5	-1.6	1.5
Noisy workplace	1.8	2.2	5.7	-0.9	-2.4	0.4
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	0.5	-0.2	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.7	1.0	1.3	-0.3
Mouth/teeth dental problems: Dentures	0.4	0.6	1.3	-0.7	-0.1	1.1
Asthma	0.2	0.4	0.7	-0.6	-0.8	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.4	0.3	-0.7	0.1
Medication: Cholesterol lowering	0.6	0.9	1.2	1.1	0.6	-1.0
Depression (self-reported)	3.5	4.2	10.4	1.0	-3.2	-1.0
Medication: Lansoprazole	0.8	0.9	1.8	-1.3	-0.6	0.8
Prospective memory result	0.5	0.6	0.8	0.4	-0.9	-0.9
Lung cancer (father)	0.9	1.0	1.5	1.2	0.4	-1.2
Illnesses of mother	1.3	1.6	3.3	-0.8	1.8	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.6	1.4	0.3	-1.9
Pulse wave Arterial Stiffness index	0.7	0.8	1.1	1.0	0.8	-0.8
Impedance of arm (left)	2.4	11.1	19.4	-3.5	1.2	4.4
Arm fat mass (right)	0.8	3.1	6.8	2.6	-0.6	-1.5
Trunk predicted mass	0.5	2.6	5.0	1.0	-1.4	-2.2
Standing height	0.3	2.8	5.7	-2.4	-0.6	1.5
Length of working week for main job	1.3	1.5	3.0	0.5	-1.7	-1.1
Exposure to tobacco smoke at home	2.1	2.4	5.6	1.1	-2.4	-0.5
Breastfed as a baby	0.2	0.2	0.4	-0.3	-0.6	0.3
Tense / ‘highly strung’	0.3	0.6	1.7	-0.0	-1.3	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	6.2	9.5	10.8	2.9	-3.1	-3.3
Hair/balding pattern: Pattern 4	1.1	2.7	6.6	1.1	2.6	-0.6
Birth weight of first child	0.0	0.0	0.0	-0.1	0.1	0.0
Peak expiratory flow (PEF)	0.3	0.8	0.8	-0.9	-0.8	0.9
Pulse wave reflection index	0.4	0.5	0.7	-0.4	-0.8	0.7
Ever highly irritable/argumentative for 2 days	1.4	1.7	4.0	-0.9	-2.0	0.6
Loud music exposure frequency	1.3	1.4	3.0	-1.7	-0.4	1.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.2	1.1	0.8	-0.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.0	0.2	-1.0	-0.5
Blood clot in the leg (DVT)	1.1	1.4	2.3	-1.2	-1.5	0.8
Medication: Paracetamol	1.7	2.9	4.8	2.2	-0.4	-1.9
Headache pain in last month	3.0	5.2	8.9	-2.6	0.1	3.0
Medication for cholesterol, blood pressure or diabetes	2.5	4.1	7.2	-2.3	-0.0	2.7
Glaucoma (self-reported)	0.5	0.6	1.2	1.1	-0.6	-0.5
Gout (self-reported)	0.1	0.1	0.3	0.1	0.5	0.1
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	3.0	-1.6	1.7	1.1
Medication: Amlodipine	0.9	1.3	2.1	1.5	-0.8	-1.0
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.8	1.0	0.1	-1.3
Birth weight	1.1	2.4	5.2	2.3	-0.2	-1.4
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.4	0.8	-1.9	-0.9
High blood pressure (siblings)	2.8	4.0	6.6	2.3	-0.2	-2.6
Forced vital capacity (FVC), Best measure	0.2	0.7	1.3	0.7	0.5	-1.2
Body fat percentage	0.4	1.6	4.5	2.1	0.6	-0.2
Leg fat percentage (right)	0.5	1.7	4.6	2.1	0.2	-0.7
Arm fat-free mass (right)	1.1	5.4	9.8	2.3	-1.1	-3.1
Exposure to tobacco smoke outside home	0.1	0.2	0.4	0.1	-0.7	-0.3
Comparative body size at age 10	2.3	6.4	11.5	3.4	0.1	-2.8
Number of full brothers	0.6	0.8	1.4	-1.2	-0.0	0.9
Worry too long after embarrassment	1.3	2.2	4.5	2.1	-0.3	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.2	0.1	-1.5	-0.5
Wheeze or whistling in the chest in last year	0.3	0.6	1.7	-0.0	-1.3	0.4
Number of children fathered	0.1	0.1	0.2	-0.5	-0.1	0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	1.8	1.3	1.3	-0.5
Age at first live birth	0.2	0.3	0.8	-0.0	0.9	-0.2
Pulse wave peak to peak time	0.8	0.9	1.1	-1.1	-1.0	0.8
Health satisfaction	0.4	0.5	1.4	-1.2	-0.4	0.2
Shortness of breath walking on level ground	1.6	2.0	4.1	1.3	-0.3	-2.0
Qualifications: College or University degree	0.1	0.2	0.3	0.5	0.4	-0.5
Eye problems/disorders: None of the above	0.2	0.2	0.3	-0.5	0.6	0.4
Mouth/teeth dental problems: Loose teeth	1.3	1.5	2.2	1.5	-0.5	-1.4
Emphysema/chronic bronchitis	0.6	0.6	0.9	-1.0	0.7	0.7
Medication for pain relief, constipation, heartburn	0.8	1.3	2.4	-0.9	1.6	0.8
Neck or shoulder pain in last month	2.1	3.0	8.3	0.4	-2.9	-0.7
Medication: Blood pressure	3.1	5.4	9.0	2.6	-0.6	-3.0
Angina (self-reported)	0.8	1.1	1.9	-1.4	-1.0	0.7
Migraine (self-reported)	0.7	0.9	1.3	-0.7	-1.1	1.0
Medication: Ibuprofen	0.2	0.2	0.5	0.4	-0.7	-0.1
Medication: Allopurinol	0.5	0.6	0.7	0.9	0.7	-0.7
Medication: Omeprazole	0.6	0.7	2.0	0.1	-1.4	0.0
Medication: Seretide 50 evohaler	0.5	0.6	0.8	0.9	0.5	-0.9
Mean time to correctly identify matches	0.4	0.7	1.3	0.3	-1.1	-0.8
Heart disease (mother)	0.3	0.3	1.0	1.0	0.0	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	1.6	1.3	-1.2	-1.1
Whole body fat mass	0.6	2.6	6.4	2.5	0.2	-1.2
Leg fat mass (right)	0.9	3.6	8.2	2.9	-0.0	-1.6
Arm predicted mass (right)	1.2	6.1	11.0	2.4	-1.2	-3.3
Pulse rate, automated reading	0.4	1.2	2.4	-0.9	1.5	0.5
Alcohol intake frequency.	2.3	5.3	8.7	-2.9	-1.7	2.1
Comparative height size at age 10	0.7	4.1	7.6	-2.8	-0.3	2.2
Number of full sisters	0.2	0.3	0.6	-0.5	0.8	0.0
Suffer from ‘nerves’	0.5	0.9	1.1	-0.7	1.0	1.0
Overall health rating	1.1	2.4	3.4	-1.2	-1.5	1.8
Chest pain or discomfort	1.8	2.6	4.8	1.8	-0.2	-2.2
Had major operations	0.2	0.3	0.6	0.5	0.8	-0.1
Age at last live birth	0.1	0.2	0.5	0.2	-0.1	-0.7
Family relationship satisfaction	0.2	0.3	0.7	-0.8	-0.3	0.2
Leg pain on walking	1.2	1.4	2.8	0.6	-1.1	-1.7
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.7	0.4	-0.9	0.1
Commuting to job workplace: Car/motor vehicle	2.0	2.3	4.7	1.2	-2.2	-0.9
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	0.1	0.7	-0.0
Medication: Aspirin	0.5	0.6	1.0	-0.7	0.6	1.0
Supplements: Vitamin C	0.7	0.8	1.1	0.7	1.1	-0.8
Knee pain experienced in last month	1.8	2.8	5.5	1.3	-2.4	-1.1
Hypertension (Self-reported)	1.0	2.8	4.5	1.9	-0.5	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.4	0.3	-0.5	-0.7
Illnesses of father: Heart disease	0.1	0.1	0.2	0.5	0.1	-0.2
Illnesses of siblings: Diabetes	0.4	0.5	0.9	0.9	-0.2	-0.8
Smoking status: Previous	0.3	0.5	0.6	0.5	-0.8	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.2	-0.4	-0.1	0.3
Whole body fat-free mass	0.7	4.1	7.6	1.9	-1.1	-2.8
Leg fat-free mass (right)	1.2	6.3	10.2	2.9	-0.5	-3.2
Arm fat percentage (left)	0.8	3.0	7.8	2.8	0.5	-1.0
Average weekly red wine intake	1.1	1.7	3.5	-0.8	1.9	0.9
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	0.5	-0.6	-0.9
Mood swings	0.2	0.3	0.8	0.9	-0.1	-0.4
Loneliness, isolation	0.7	1.0	3.1	0.1	-1.8	0.1
Long-standing illness, disability or infirmity	0.0	0.0	0.1	0.2	-0.2	-0.3
Ever had bowel cancer screening	3.9	4.6	7.7	2.8	-0.4	-2.4
Diabetes diagnosed by doctor	0.8	1.2	2.4	0.7	-1.5	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	0.5	-0.4	-0.8
Friendships satisfaction	0.0	0.0	0.1	-0.0	-0.2	-0.1
Qualifications: nursing, teaching	0.4	0.7	1.1	1.0	0.0	-0.9
Commuting to job workplace: Walk	1.5	1.6	2.5	-1.6	0.5	1.4
Eye problems/disorders: Cataract	0.1	0.2	0.3	0.3	0.5	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.5	2.3	3.2	1.0	-1.7	-1.8
Medication for cholesterol	0.3	0.5	0.7	-0.7	0.5	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	3.2	1.3	-0.5	-1.8
Back pain experienced in last month	2.1	3.1	8.5	-0.9	-2.9	0.3
Mineral and other dietary supplements	1.1	1.4	1.7	-1.0	-1.3	1.2
Breast cancer (self-reported)	0.3	0.3	0.9	0.4	-0.9	-0.1
Asthma (self-reported)	0.1	0.3	0.4	-0.7	-0.6	0.1
Osteoporosis (self-reported)	0.2	0.3	0.6	0.5	0.3	0.7
Osteoarthritis (self-reported)	0.2	0.2	0.4	0.5	-0.6	-0.1
Medication: Aspirin	0.8	1.1	1.5	-1.1	0.7	1.2
Medication: Gliclazide	1.6	1.8	3.0	1.1	-1.0	-1.7
Illnesses of father: None of the above (group 1)	0.4	0.5	1.0	-1.0	-0.7	0.2
Smoking status: Current	0.2	0.2	0.6	-0.3	0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.5	9.5	3.1	-0.2	-2.6
Whole body water mass	0.8	4.3	7.7	1.9	-1.3	-2.8
Leg predicted mass (right)	1.2	6.2	10.1	2.9	-0.5	-3.2
Arm fat mass (left)	0.9	3.6	7.7	2.8	-0.6	-1.7
Number of self-reported non-cancer illnesses	1.5	2.7	4.5	1.7	0.7	-2.1
Average weekly champagne plus white wine intake	1.2	1.7	3.2	1.8	0.5	-1.3
Miserableness	0.9	1.6	3.8	0.3	-2.0	0.9
Guilty feelings	4.6	6.8	11.5	3.4	-1.4	-2.7
Wears glasses or contact lenses	0.5	0.6	1.7	0.4	1.3	0.1
Ever taken oral contraceptive pill	0.9	1.0	1.3	1.1	1.0	-0.8
Hearing aid user	0.6	0.7	1.0	-1.0	-0.2	1.0
Mother’s age at death	0.4	0.5	0.9	0.7	-1.0	0.0
Financial situation satisfaction	0.6	0.7	1.6	-0.7	-1.3	0.2
Tinnitus: Yes, now most or all of the time	0.9	1.0	1.4	-0.9	-0.9	1.2
Commuting to job workplace: Public transport	1.5	1.8	4.8	-0.3	2.2	0.7
Eye problems/disorders: Glaucoma	0.7	0.8	1.8	1.4	0.5	-0.6
Medication: Blood pressure	0.1	0.1	0.3	0.0	-0.6	0.1
Pain type(s) experienced in last month: Hip pain	2.6	3.3	3.7	1.9	-1.7	-1.8
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.6	-0.8	0.2	0.6
High cholesterol (Self-reported)	0.1	0.3	0.4	0.4	-0.4	-0.6
Medication: Bendroflumethiazide	0.9	1.3	2.0	1.0	-1.1	-1.4
Medication: Paracetamol	1.1	1.7	2.3	1.5	-0.9	-1.5
Medication: Lisinopril	0.2	0.3	0.5	0.7	0.3	-0.4
Medication: Atorvastatin	0.1	0.1	0.2	-0.0	-0.3	0.4
Illnesses of father: High blood pressure	1.1	1.3	2.7	1.6	0.5	-1.0
Alcohol drinker status: Never	0.3	0.3	1.0	-0.1	0.2	-1.0
Ever smoked	1.1	1.9	3.8	-1.1	-0.7	2.0
Basal metabolic rate	0.7	4.0	6.7	2.1	-1.0	-2.6
Leg fat percentage (left)	0.6	2.1	5.5	2.4	0.3	-0.9
Arm fat-free mass (left)	0.8	3.9	6.2	1.6	-1.7	-2.5
Number of operations (self-reported)	1.9	2.8	3.9	2.0	-1.6	-1.3
Average weekly beer plus cider intake	0.2	0.3	0.7	-0.1	0.4	0.8
Irritability	4.3	7.3	14.5	2.0	-3.8	-1.8
Risk taking	0.3	0.5	1.1	0.5	-0.1	-1.1
Ever had prostate specific antigen (PSA) test	1.2	1.4	4.0	0.2	2.0	0.4
Fractured/broken bones in last 5 years	3.4	4.4	7.1	2.4	0.1	-2.7
Age started oral contraceptive pill	1.0	1.2	1.8	1.4	-0.1	-1.3
Diastolic blood pressure, automated reading	0.1	0.4	0.8	0.6	0.9	-0.3
Ever depressed for a whole week	0.4	0.4	1.0	0.4	-1.0	-0.4
Unable to work because of sickness or disability	2.0	2.6	6.4	-1.2	-2.5	0.2
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.4	-0.0	-0.3
Myopia	0.4	0.6	1.1	-0.6	1.1	0.6
Vascular/heart problems diagnosed by doctor	1.9	5.2	9.1	-2.6	-0.2	3.0
Cholesterol lowering medication	0.0	0.0	0.1	-0.2	0.3	0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.4	0.1	-1.2	-0.0
Pain experienced in last month	2.2	3.7	10.6	0.6	3.3	0.1
Supplements: Calcium	0.0	0.0	0.1	0.2	0.0	0.3
Basal cell carcinoma (self-reported)	0.2	0.3	0.7	-0.8	-0.1	0.3
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.9	0.3	2.0	-0.1
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	1.9	-1.2	-1.4	0.9
Heart disease (siblings)	2.3	2.8	3.7	1.9	-1.5	-1.6
Alcohol drinker status: Previous	0.3	0.4	0.6	0.6	-0.4	-0.8
Pack years of smoking	0.4	0.5	0.8	0.7	0.5	-0.9
Impedance of whole body	3.2	16.5	28.1	-4.5	1.0	5.3
Leg fat mass (left)	1.1	4.4	9.6	3.1	-0.0	-1.9
Arm predicted mass (left)	0.9	4.5	6.9	1.8	-1.8	-2.6