Hub : Genes

C22orf25

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0421 0.0105 2.4e-08 0.042 0.033 0.036 0.04 0.038 2.4e-13 4.9e-11 6.7e-12 8.3e-13 2.3e-12
2 TCGA Lung Squamous Cell Carcinoma 0.0571 0.0289 2.6e-03 0.000 0.011 0.003 NA 0.001 3.4e-01 1.6e-02 1.3e-01 NA 2.2e-01
3 TCGA Thyroid Carcinoma 0.1010 0.0350 3.7e-08 0.117 0.092 0.110 NA 0.115 1.9e-11 3.1e-09 8.6e-11 NA 3.0e-11

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 2.7 4.3 6.7 -2.1 1.4 2.6
Bipolar Disorder or Schizophrenia 1.5 3.7 5.6 -2.2 0.9 2.4
Depressed Affect (Nagel 2018) 0.3 0.6 1.0 0.8 -1.0 0.4
Depression (Nagel 2018) 1.7 2.5 5.1 1.1 -2.3 -1.2
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.2 0.1 1.1 -0.0
Neuroticism (Nagel 2018) 1.0 2.3 3.2 1.8 -1.7 -0.8
Schizophrenia (2018) 0.3 0.7 1.2 -1.1 -0.0 1.0
Schizophrenia vs Biploar Disorder 0.1 0.2 0.3 0.3 -0.1 -0.6
Worry (Nagel 2018) 0.1 0.2 0.3 0.6 -0.5 0.2
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 -0.1 -0.5 0.2
Alzheimer’s Disease (in father) 1.0 1.1 2.6 -0.7 1.6 0.3
Alzheimer’s Disease (including proxy) 0.1 0.1 0.3 -0.5 0.3 0.3
Crohns Disease (2017) 0.2 0.5 0.9 -0.8 -0.9 0.2
Irritable Bowel Disease (IBD) 0.2 0.6 1.4 -1.2 -0.5 -0.1
Ulcerative Colitis (UC) 0.5 1.0 2.7 -1.6 -0.1 0.4
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.1 0.3 0.6 -0.5 -0.7 -0.2
Verbal and Numeric Reasoning (VNR) 0.4 1.0 1.8 -1.0 0.3 1.3
Breast Cancer 1.1 2.6 4.7 1.7 -0.6 -2.2
Ovarian Cancer 0.9 1.2 2.5 -1.1 0.0 1.6
Prostate Cancer 2.8 3.9 5.9 -2.4 -1.3 2.0
Age at First Birth 0.9 1.4 1.8 1.1 1.3 -1.1
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.9 1.2 1.0 0.7 -1.1
Coronary Artery Disease (CAD) 0.8 1.0 2.2 -0.7 1.5 0.6
Crohns Disease (2012) 1.0 1.6 2.3 -1.5 -1.5 0.5
Mean Putamen Volume 5.5 6.3 8.0 -2.8 -1.8 2.8
Fasting Glucose 0.4 0.5 1.3 0.2 -1.1 0.2
HbA1C 0.2 0.2 0.6 -0.1 0.8 0.2
HDL Cholesterol 0.3 0.5 0.9 1.0 0.4 -0.7
LDL Cholesterol 0.2 0.3 0.5 0.3 -0.7 -0.5
Lupus 0.1 0.2 0.4 0.0 -0.6 -0.2
Neuroticism (2016) 2.3 3.3 7.9 1.1 -2.8 -0.8
Primary Biliary Cirrhosis 2.1 3.0 7.1 -1.2 2.7 0.7
Rheumatoid Arthritis 0.1 0.1 0.3 0.1 0.6 0.0
Schizophrenia (2014) 0.3 0.6 1.4 -1.2 0.2 0.7
Triglycerides 0.1 0.1 0.4 -0.0 -0.1 0.7
Type 2 Diabetes (T2D) (2012) 0.3 0.4 0.7 0.5 0.9 0.5
Ulcerative Colitis 0.5 0.8 2.2 -1.5 -0.4 0.1
Blood Eosinophil Count 1.2 9.5 13.5 3.7 1.3 -3.7
Blood Platelet Count 0.3 3.1 5.8 1.8 0.5 -2.4
Blood Red Count 0.7 6.4 8.5 -2.9 -1.5 2.9
Blood White Count 0.2 1.7 4.7 -0.7 2.2 -0.2
Heel T-Score 1.6 12.8 29.5 -5.4 -0.2 3.0
BMI 2.5 14.4 23.3 4.8 -0.0 -4.5
Height 0.2 3.8 6.4 -2.5 -1.3 1.9
Waist Hip Ratio (WHR) 0.5 2.3 3.2 1.8 1.1 -1.6
Systolic Blood Pressure 1.7 8.4 11.4 3.4 2.5 -2.8
Smoking Status 0.6 1.5 2.3 1.5 -0.6 -1.4
Allergy or Eczema 0.2 0.5 1.1 0.5 -0.4 -1.0
Cardiovascular Disease 1.4 4.5 7.6 2.4 0.2 -2.8
Hypothyroidism (self reported) 0.9 2.0 3.2 -1.8 0.7 1.6
Respiratory disease 0.3 0.6 1.3 -1.2 -0.3 0.6
Type 2 Diabetes (T2D) (2018) 0.9 1.7 2.5 1.1 -1.6 -1.2
Lung FEV1/FVC ratio 0.5 2.6 2.9 1.6 -1.7 -1.5
Lung FVC 0.9 4.4 7.2 2.4 0.5 -2.7
Neuroticism 1.7 4.1 7.7 1.8 -2.8 -1.1
Chronotype (morning person) 0.1 0.3 0.8 -0.9 0.1 -0.2
Hair Pigment 0.0 0.5 0.7 -0.6 -0.7 0.9
Tanning 0.2 2.7 7.5 -0.5 2.7 0.7
Hand grip strength (left) 0.1 0.2 0.4 -0.3 -0.4 -0.6
Number of treatments/medications taken 2.5 4.5 6.8 2.6 0.3 -2.6
Average weekly spirits intake 2.4 3.0 4.0 -2.0 1.6 1.6
Sensitivity / hurt feelings 0.9 1.5 3.5 1.9 -0.3 -0.9
Frequency of depressed mood in last 2 weeks 1.4 2.0 3.9 0.6 -2.0 -1.3
Hearing difficulty/problems: Yes 0.0 0.0 0.0 0.1 0.0 0.2
Relative age of first facial hair 0.3 0.6 1.2 -0.7 -0.3 1.1
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 3.0 0.2 1.7 -0.3
Ever used hormone-replacement therapy (HRT) 1.0 1.3 3.7 -0.0 -1.9 -0.5
Ever had hysterectomy (womb removed) 1.9 2.2 4.5 -1.2 -2.1 0.8
Systolic blood pressure, automated reading 2.8 8.1 11.4 2.9 3.4 -2.1
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 4.0 0.0 -2.0 -0.1
Angina 0.5 0.7 1.3 -1.2 -0.6 0.5
Medication for hormone replacement therapy 1.3 1.4 2.2 0.5 -1.5 -1.4
Vitamin and mineral supplements 0.1 0.1 0.3 -0.1 -0.5 -0.2
Supplements: Zinc 0.6 0.6 1.3 0.4 1.2 -0.6
Medication: Co-codamol 1.4 1.6 3.8 0.3 -1.9 -0.9
Medication: Metformin 1.3 1.9 4.6 0.7 -2.1 -0.8
Diabetes (father) 0.9 1.2 2.0 0.9 0.8 -1.4
Diabetes (mother) 0.5 0.6 1.3 0.2 -1.1 -0.8
Severe depression (siblings) 0.3 0.3 0.5 0.7 -0.3 -0.5
Pack years adult smoking proportion 0.3 0.4 0.4 0.7 0.5 -0.7
Impedance of leg (right) 3.3 16.1 26.5 -4.6 0.7 5.1
Leg fat-free mass (left) 1.1 6.0 9.7 2.8 -0.5 -3.1
Trunk fat percentage 0.4 1.5 4.2 2.1 0.6 -0.1
Hand grip strength (right) 0.1 0.2 0.3 -0.4 0.6 -0.4
Townsend deprivation index at recruitment 1.4 2.0 3.6 1.5 -0.1 -1.9
Current tobacco smoking 0.2 0.4 0.8 -0.5 0.4 0.9
Average weekly fortified wine intake 0.2 0.2 0.4 -0.6 -0.5 0.4
Maternal smoking around birth 0.0 0.0 0.1 -0.0 -0.4 -0.1
Fed-up feelings 0.1 0.2 0.6 0.8 -0.0 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.9 2.6 4.7 1.4 -2.2 -1.0
Relative age voice broke 0.5 0.8 1.1 1.1 0.8 -0.7
Taking other prescription medications 3.7 5.7 9.0 2.7 0.8 -3.0
Age when periods started (menarche) 1.0 2.4 3.6 1.9 1.4 -1.3
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.8 -0.3 -0.9 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.5 3.1 -1.8 -0.3 1.2
Tinnitus: Yes, but not now, but have in the past 2.2 2.3 6.9 0.2 2.6 -0.2
Qualifications: CSEs or equivalent 1.0 1.4 4.0 0.2 -2.0 0.0
Serious illness, injury or assault to yourself 1.0 1.2 2.4 1.0 0.3 -1.6
High blood pressure 1.3 3.7 6.2 2.2 -0.2 -2.5
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.5 0.4 0.7 -0.7
Multivitamins +/- minerals 0.7 0.9 2.2 1.5 0.6 -0.4
Stomach or abdominal pain in last month 0.1 0.1 0.1 0.3 0.2 0.3
Supplements: Glucosamine 1.5 1.9 3.0 1.7 0.6 -1.6
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.0 1.0 -0.3 -0.6
Medication: Atenolol 0.5 0.6 1.5 0.4 1.2 -0.2
Medication: Levothyroxine sodium 1.7 2.8 5.1 -2.2 1.0 1.6
Sitting height 0.0 0.2 0.4 -0.3 -0.6 -0.1
Chronic bronchitis/emphysema (father) 0.6 0.7 1.8 -0.3 0.5 1.4
High blood pressure (mother) 0.9 1.2 2.1 1.4 -0.4 -1.2
Body mass index (BMI) 1.8 7.7 14.3 3.8 -0.3 -2.9
Impedance of leg (left) 3.0 14.7 24.7 -4.3 0.7 5.0
Leg predicted mass (left) 1.1 5.7 9.1 2.8 -0.5 -3.0
Trunk fat mass 0.5 2.3 6.2 2.5 0.3 -0.9
Waist circumference 2.0 7.2 12.7 3.6 -0.1 -3.0
Number of incorrect matches in round 0.6 1.0 3.1 -0.1 1.8 -0.1
Past tobacco smoking 0.1 0.3 0.6 0.1 0.8 -0.4
Alcohol usually taken with meals 0.4 0.6 1.1 -0.8 0.3 1.0
Nervous feelings 1.8 3.4 5.3 -1.9 1.2 2.3
Frequency of tenseness / restlessness in last 2 weeks 1.5 2.3 2.5 1.5 -1.6 -1.4
Hearing difficulty/problems with background noise 1.7 2.8 3.1 1.6 -1.7 -1.8
Hair/balding pattern: Pattern 2 2.8 3.6 10.3 -0.1 -3.2 -0.7
Had menopause 0.9 1.2 2.6 0.9 -0.4 -1.6
Had other major operations 0.3 0.3 1.0 0.1 -1.0 0.2
Forced vital capacity (FVC) 0.2 0.8 1.3 0.9 0.4 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 4.3 -2.1 -1.0 1.3
Ever unenthusiastic/disinterested for a whole week 1.1 1.4 3.9 0.2 -2.0 -0.5
Qualifications: None of the above 0.6 1.3 2.7 1.1 0.2 -1.6
Financial difficulties in last 2 years 0.2 0.2 0.3 -0.2 -0.6 0.6
Mouth/teeth dental problems 0.4 0.6 1.8 0.2 1.3 0.1
Heart attack 1.1 1.4 3.6 0.6 1.9 -0.3
Allergy 0.0 0.0 0.1 0.1 -0.1 0.3
Pain all over the body in last month 1.7 1.8 3.5 1.2 -0.7 -1.9
Diabetes (self-reported) 0.7 1.1 2.0 0.7 -1.4 -0.9
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.9 1.0 0.3 -0.7
Medication: Ramipril 2.1 2.7 3.1 1.8 1.5 -1.7
Medication: Simvastatin 0.6 0.9 1.1 1.1 0.9 -0.9
Fluid intelligence score 0.1 0.1 0.3 0.0 0.6 0.1
Illnesses of siblings 2.6 3.6 5.7 -2.4 0.8 2.1
Neuroticism score 0.6 1.3 2.9 1.7 -1.0 -0.4
Weight 0.8 4.0 7.0 2.6 -0.4 -2.2
Impedance of arm (right) 3.4 15.6 27.6 -4.4 0.6 5.2
Arm fat percentage (right) 0.4 1.7 5.0 2.2 -0.0 -0.4
Trunk fat-free mass 0.5 2.7 5.3 1.1 -1.3 -2.3
Hip circumference 0.9 4.0 6.1 2.5 -1.3 -2.0
Time employed in main current job 0.5 0.5 0.8 0.9 0.5 -0.7
Alcohol intake versus 10 years previously 0.0 0.0 0.0 0.1 0.1 -0.2
Father’s age at death 0.3 0.4 0.6 -0.8 -0.6 0.4
Worrier / anxious feelings 0.2 0.4 0.8 0.9 -0.3 0.4
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 1.3 0.9 -1.2 -0.8
Falls in the last year 2.3 3.2 7.1 -1.5 -2.7 -0.1
Hair/balding pattern: Pattern 3 0.5 0.7 1.1 -1.0 -0.3 1.0
Number of live births 4.6 6.5 8.9 -2.9 -1.4 3.0
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 2.4 1.3 0.2 -1.6
Pulse rate 1.0 1.7 3.0 1.4 -0.0 -1.7
Happiness 3.0 3.6 6.0 -2.5 -1.6 1.5
Noisy workplace 1.8 2.2 5.7 -0.9 -2.4 0.4
Qualifications: A levels/AS levels or equivalent 0.0 0.1 0.2 0.5 -0.2 -0.3
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 1.7 1.0 1.3 -0.3
Mouth/teeth dental problems: Dentures 0.4 0.6 1.3 -0.7 -0.1 1.1
Asthma 0.2 0.4 0.7 -0.6 -0.8 0.0
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.4 0.3 -0.7 0.1
Medication: Cholesterol lowering 0.6 0.9 1.2 1.1 0.6 -1.0
Depression (self-reported) 3.5 4.2 10.4 1.0 -3.2 -1.0
Medication: Lansoprazole 0.8 0.9 1.8 -1.3 -0.6 0.8
Prospective memory result 0.5 0.6 0.8 0.4 -0.9 -0.9
Lung cancer (father) 0.9 1.0 1.5 1.2 0.4 -1.2
Illnesses of mother 1.3 1.6 3.3 -0.8 1.8 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.9 3.6 1.4 0.3 -1.9
Pulse wave Arterial Stiffness index 0.7 0.8 1.1 1.0 0.8 -0.8
Impedance of arm (left) 2.4 11.1 19.4 -3.5 1.2 4.4
Arm fat mass (right) 0.8 3.1 6.8 2.6 -0.6 -1.5
Trunk predicted mass 0.5 2.6 5.0 1.0 -1.4 -2.2
Standing height 0.3 2.8 5.7 -2.4 -0.6 1.5
Length of working week for main job 1.3 1.5 3.0 0.5 -1.7 -1.1
Exposure to tobacco smoke at home 2.1 2.4 5.6 1.1 -2.4 -0.5
Breastfed as a baby 0.2 0.2 0.4 -0.3 -0.6 0.3
Tense / ‘highly strung’ 0.3 0.6 1.7 -0.0 -1.3 0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 6.2 9.5 10.8 2.9 -3.1 -3.3
Hair/balding pattern: Pattern 4 1.1 2.7 6.6 1.1 2.6 -0.6
Birth weight of first child 0.0 0.0 0.0 -0.1 0.1 0.0
Peak expiratory flow (PEF) 0.3 0.8 0.8 -0.9 -0.8 0.9
Pulse wave reflection index 0.4 0.5 0.7 -0.4 -0.8 0.7
Ever highly irritable/argumentative for 2 days 1.4 1.7 4.0 -0.9 -2.0 0.6
Loud music exposure frequency 1.3 1.4 3.0 -1.7 -0.4 1.0
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.2 1.1 0.8 -0.7
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.0 0.2 -1.0 -0.5
Blood clot in the leg (DVT) 1.1 1.4 2.3 -1.2 -1.5 0.8
Medication: Paracetamol 1.7 2.9 4.8 2.2 -0.4 -1.9
Headache pain in last month 3.0 5.2 8.9 -2.6 0.1 3.0
Medication for cholesterol, blood pressure or diabetes 2.5 4.1 7.2 -2.3 -0.0 2.7
Glaucoma (self-reported) 0.5 0.6 1.2 1.1 -0.6 -0.5
Gout (self-reported) 0.1 0.1 0.3 0.1 0.5 0.1
Hypothyroidism/myxoedema (self-reported) 1.1 2.2 3.0 -1.6 1.7 1.1
Medication: Amlodipine 0.9 1.3 2.1 1.5 -0.8 -1.0
Medication: Ventolin 100micrograms inhaler 0.7 0.9 1.8 1.0 0.1 -1.3
Birth weight 1.1 2.4 5.2 2.3 -0.2 -1.4
Chronic bronchitis/emphysema (mother) 1.4 1.6 3.4 0.8 -1.9 -0.9
High blood pressure (siblings) 2.8 4.0 6.6 2.3 -0.2 -2.6
Forced vital capacity (FVC), Best measure 0.2 0.7 1.3 0.7 0.5 -1.2
Body fat percentage 0.4 1.6 4.5 2.1 0.6 -0.2
Leg fat percentage (right) 0.5 1.7 4.6 2.1 0.2 -0.7
Arm fat-free mass (right) 1.1 5.4 9.8 2.3 -1.1 -3.1
Exposure to tobacco smoke outside home 0.1 0.2 0.4 0.1 -0.7 -0.3
Comparative body size at age 10 2.3 6.4 11.5 3.4 0.1 -2.8
Number of full brothers 0.6 0.8 1.4 -1.2 -0.0 0.9
Worry too long after embarrassment 1.3 2.2 4.5 2.1 -0.3 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.2 0.1 -1.5 -0.5
Wheeze or whistling in the chest in last year 0.3 0.6 1.7 -0.0 -1.3 0.4
Number of children fathered 0.1 0.1 0.2 -0.5 -0.1 0.0
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.2 1.8 1.3 1.3 -0.5
Age at first live birth 0.2 0.3 0.8 -0.0 0.9 -0.2
Pulse wave peak to peak time 0.8 0.9 1.1 -1.1 -1.0 0.8
Health satisfaction 0.4 0.5 1.4 -1.2 -0.4 0.2
Shortness of breath walking on level ground 1.6 2.0 4.1 1.3 -0.3 -2.0
Qualifications: College or University degree 0.1 0.2 0.3 0.5 0.4 -0.5
Eye problems/disorders: None of the above 0.2 0.2 0.3 -0.5 0.6 0.4
Mouth/teeth dental problems: Loose teeth 1.3 1.5 2.2 1.5 -0.5 -1.4
Emphysema/chronic bronchitis 0.6 0.6 0.9 -1.0 0.7 0.7
Medication for pain relief, constipation, heartburn 0.8 1.3 2.4 -0.9 1.6 0.8
Neck or shoulder pain in last month 2.1 3.0 8.3 0.4 -2.9 -0.7
Medication: Blood pressure 3.1 5.4 9.0 2.6 -0.6 -3.0
Angina (self-reported) 0.8 1.1 1.9 -1.4 -1.0 0.7
Migraine (self-reported) 0.7 0.9 1.3 -0.7 -1.1 1.0
Medication: Ibuprofen 0.2 0.2 0.5 0.4 -0.7 -0.1
Medication: Allopurinol 0.5 0.6 0.7 0.9 0.7 -0.7
Medication: Omeprazole 0.6 0.7 2.0 0.1 -1.4 0.0
Medication: Seretide 50 evohaler 0.5 0.6 0.8 0.9 0.5 -0.9
Mean time to correctly identify matches 0.4 0.7 1.3 0.3 -1.1 -0.8
Heart disease (mother) 0.3 0.3 1.0 1.0 0.0 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 1.6 1.3 -1.2 -1.1
Whole body fat mass 0.6 2.6 6.4 2.5 0.2 -1.2
Leg fat mass (right) 0.9 3.6 8.2 2.9 -0.0 -1.6
Arm predicted mass (right) 1.2 6.1 11.0 2.4 -1.2 -3.3
Pulse rate, automated reading 0.4 1.2 2.4 -0.9 1.5 0.5
Alcohol intake frequency. 2.3 5.3 8.7 -2.9 -1.7 2.1
Comparative height size at age 10 0.7 4.1 7.6 -2.8 -0.3 2.2
Number of full sisters 0.2 0.3 0.6 -0.5 0.8 0.0
Suffer from ‘nerves’ 0.5 0.9 1.1 -0.7 1.0 1.0
Overall health rating 1.1 2.4 3.4 -1.2 -1.5 1.8
Chest pain or discomfort 1.8 2.6 4.8 1.8 -0.2 -2.2
Had major operations 0.2 0.3 0.6 0.5 0.8 -0.1
Age at last live birth 0.1 0.2 0.5 0.2 -0.1 -0.7
Family relationship satisfaction 0.2 0.3 0.7 -0.8 -0.3 0.2
Leg pain on walking 1.2 1.4 2.8 0.6 -1.1 -1.7
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 0.7 0.4 -0.9 0.1
Commuting to job workplace: Car/motor vehicle 2.0 2.3 4.7 1.2 -2.2 -0.9
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.5 0.1 0.7 -0.0
Medication: Aspirin 0.5 0.6 1.0 -0.7 0.6 1.0
Supplements: Vitamin C 0.7 0.8 1.1 0.7 1.1 -0.8
Knee pain experienced in last month 1.8 2.8 5.5 1.3 -2.4 -1.1
Hypertension (Self-reported) 1.0 2.8 4.5 1.9 -0.5 -2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.4 0.3 -0.5 -0.7
Illnesses of father: Heart disease 0.1 0.1 0.2 0.5 0.1 -0.2
Illnesses of siblings: Diabetes 0.4 0.5 0.9 0.9 -0.2 -0.8
Smoking status: Previous 0.3 0.5 0.6 0.5 -0.8 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.2 -0.4 -0.1 0.3
Whole body fat-free mass 0.7 4.1 7.6 1.9 -1.1 -2.8
Leg fat-free mass (right) 1.2 6.3 10.2 2.9 -0.5 -3.2
Arm fat percentage (left) 0.8 3.0 7.8 2.8 0.5 -1.0
Average weekly red wine intake 1.1 1.7 3.5 -0.8 1.9 0.9
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.9 0.5 -0.6 -0.9
Mood swings 0.2 0.3 0.8 0.9 -0.1 -0.4
Loneliness, isolation 0.7 1.0 3.1 0.1 -1.8 0.1
Long-standing illness, disability or infirmity 0.0 0.0 0.1 0.2 -0.2 -0.3
Ever had bowel cancer screening 3.9 4.6 7.7 2.8 -0.4 -2.4
Diabetes diagnosed by doctor 0.8 1.2 2.4 0.7 -1.5 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.6 0.5 -0.4 -0.8
Friendships satisfaction 0.0 0.0 0.1 -0.0 -0.2 -0.1
Qualifications: nursing, teaching 0.4 0.7 1.1 1.0 0.0 -0.9
Commuting to job workplace: Walk 1.5 1.6 2.5 -1.6 0.5 1.4
Eye problems/disorders: Cataract 0.1 0.2 0.3 0.3 0.5 -0.3
Mouth/teeth dental problems: Mouth ulcers 1.5 2.3 3.2 1.0 -1.7 -1.8
Medication for cholesterol 0.3 0.5 0.7 -0.7 0.5 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.7 3.2 1.3 -0.5 -1.8
Back pain experienced in last month 2.1 3.1 8.5 -0.9 -2.9 0.3
Mineral and other dietary supplements 1.1 1.4 1.7 -1.0 -1.3 1.2
Breast cancer (self-reported) 0.3 0.3 0.9 0.4 -0.9 -0.1
Asthma (self-reported) 0.1 0.3 0.4 -0.7 -0.6 0.1
Osteoporosis (self-reported) 0.2 0.3 0.6 0.5 0.3 0.7
Osteoarthritis (self-reported) 0.2 0.2 0.4 0.5 -0.6 -0.1
Medication: Aspirin 0.8 1.1 1.5 -1.1 0.7 1.2
Medication: Gliclazide 1.6 1.8 3.0 1.1 -1.0 -1.7
Illnesses of father: None of the above (group 1) 0.4 0.5 1.0 -1.0 -0.7 0.2
Smoking status: Current 0.2 0.2 0.6 -0.3 0.2 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.6 5.5 9.5 3.1 -0.2 -2.6
Whole body water mass 0.8 4.3 7.7 1.9 -1.3 -2.8
Leg predicted mass (right) 1.2 6.2 10.1 2.9 -0.5 -3.2
Arm fat mass (left) 0.9 3.6 7.7 2.8 -0.6 -1.7
Number of self-reported non-cancer illnesses 1.5 2.7 4.5 1.7 0.7 -2.1
Average weekly champagne plus white wine intake 1.2 1.7 3.2 1.8 0.5 -1.3
Miserableness 0.9 1.6 3.8 0.3 -2.0 0.9
Guilty feelings 4.6 6.8 11.5 3.4 -1.4 -2.7
Wears glasses or contact lenses 0.5 0.6 1.7 0.4 1.3 0.1
Ever taken oral contraceptive pill 0.9 1.0 1.3 1.1 1.0 -0.8
Hearing aid user 0.6 0.7 1.0 -1.0 -0.2 1.0
Mother’s age at death 0.4 0.5 0.9 0.7 -1.0 0.0
Financial situation satisfaction 0.6 0.7 1.6 -0.7 -1.3 0.2
Tinnitus: Yes, now most or all of the time 0.9 1.0 1.4 -0.9 -0.9 1.2
Commuting to job workplace: Public transport 1.5 1.8 4.8 -0.3 2.2 0.7
Eye problems/disorders: Glaucoma 0.7 0.8 1.8 1.4 0.5 -0.6
Medication: Blood pressure 0.1 0.1 0.3 0.0 -0.6 0.1
Pain type(s) experienced in last month: Hip pain 2.6 3.3 3.7 1.9 -1.7 -1.8
Supplements: Fish oil (including cod liver oil) 0.3 0.3 0.6 -0.8 0.2 0.6
High cholesterol (Self-reported) 0.1 0.3 0.4 0.4 -0.4 -0.6
Medication: Bendroflumethiazide 0.9 1.3 2.0 1.0 -1.1 -1.4
Medication: Paracetamol 1.1 1.7 2.3 1.5 -0.9 -1.5
Medication: Lisinopril 0.2 0.3 0.5 0.7 0.3 -0.4
Medication: Atorvastatin 0.1 0.1 0.2 -0.0 -0.3 0.4
Illnesses of father: High blood pressure 1.1 1.3 2.7 1.6 0.5 -1.0
Alcohol drinker status: Never 0.3 0.3 1.0 -0.1 0.2 -1.0
Ever smoked 1.1 1.9 3.8 -1.1 -0.7 2.0
Basal metabolic rate 0.7 4.0 6.7 2.1 -1.0 -2.6
Leg fat percentage (left) 0.6 2.1 5.5 2.4 0.3 -0.9
Arm fat-free mass (left) 0.8 3.9 6.2 1.6 -1.7 -2.5
Number of operations (self-reported) 1.9 2.8 3.9 2.0 -1.6 -1.3
Average weekly beer plus cider intake 0.2 0.3 0.7 -0.1 0.4 0.8
Irritability 4.3 7.3 14.5 2.0 -3.8 -1.8
Risk taking 0.3 0.5 1.1 0.5 -0.1 -1.1
Ever had prostate specific antigen (PSA) test 1.2 1.4 4.0 0.2 2.0 0.4
Fractured/broken bones in last 5 years 3.4 4.4 7.1 2.4 0.1 -2.7
Age started oral contraceptive pill 1.0 1.2 1.8 1.4 -0.1 -1.3
Diastolic blood pressure, automated reading 0.1 0.4 0.8 0.6 0.9 -0.3
Ever depressed for a whole week 0.4 0.4 1.0 0.4 -1.0 -0.4
Unable to work because of sickness or disability 2.0 2.6 6.4 -1.2 -2.5 0.2
Commuting to job workplace: Cycle 0.1 0.1 0.2 -0.4 -0.0 -0.3
Myopia 0.4 0.6 1.1 -0.6 1.1 0.6
Vascular/heart problems diagnosed by doctor 1.9 5.2 9.1 -2.6 -0.2 3.0
Cholesterol lowering medication 0.0 0.0 0.1 -0.2 0.3 0.1
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.4 0.1 -1.2 -0.0
Pain experienced in last month 2.2 3.7 10.6 0.6 3.3 0.1
Supplements: Calcium 0.0 0.0 0.1 0.2 0.0 0.3
Basal cell carcinoma (self-reported) 0.2 0.3 0.7 -0.8 -0.1 0.3
Heart attack/myocardial infarction (self-reported) 1.0 1.3 3.9 0.3 2.0 -0.1
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 1.9 -1.2 -1.4 0.9
Heart disease (siblings) 2.3 2.8 3.7 1.9 -1.5 -1.6
Alcohol drinker status: Previous 0.3 0.4 0.6 0.6 -0.4 -0.8
Pack years of smoking 0.4 0.5 0.8 0.7 0.5 -0.9
Impedance of whole body 3.2 16.5 28.1 -4.5 1.0 5.3
Leg fat mass (left) 1.1 4.4 9.6 3.1 -0.0 -1.9
Arm predicted mass (left) 0.9 4.5 6.9 1.8 -1.8 -2.6