Hub : Genes

AC006547.15

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.407	0.1010	2.3e-04	0.025	NA	0.193	NA	0.106	7.8e-02	NA	1.1e-05	NA	1.1e-03
2	GTEx	Cells Transformed fibroblasts	0.106	0.0400	3.8e-03	-0.003	NA	-0.001	NA	-0.003	8.0e-01	NA	3.8e-01	NA	6.9e-01
3	GTEx	Muscle Skeletal	0.126	0.0444	2.9e-03	0.004	NA	-0.001	NA	0.007	1.2e-01	NA	3.9e-01	NA	6.8e-02
4	GTEx	Pituitary	0.331	0.1120	3.0e-03	0.023	NA	-0.001	NA	0.002	8.9e-02	NA	3.4e-01	NA	2.7e-01
5	GTEx	Thyroid	0.147	0.0440	5.2e-05	0.053	NA	0.077	NA	0.061	6.8e-05	NA	1.5e-06	NA	2.1e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.0	1.5	6.4	0.6	0.5	0.0	0.8	2.5
Bipolar Disorder or Schizophrenia	1.6	4.0	10.2	1.6	0.0	3.2	-0.1	2.7
Depressed Affect (Nagel 2018)	0.3	0.5	1.4	-0.4	-0.1	1.2	-0.7	-0.8
Depression (Nagel 2018)	1.1	1.6	4.8	-1.0	-1.1	0.8	-0.5	-2.2
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.5	-0.1	0.1	-0.0	0.4	-0.7
Neuroticism (Nagel 2018)	0.6	1.4	2.8	-1.0	-0.1	1.0	-1.5	-1.7
Schizophrenia (2018)	1.6	3.4	11.8	1.4	-0.3	3.4	-0.8	1.6
Schizophrenia vs Biploar Disorder	0.5	0.6	2.0	-0.3	-0.4	0.8	-1.4	-0.1
Worry (Nagel 2018)	0.4	0.8	3.1	-0.9	0.3	0.1	-1.8	-0.0
Alzheimer’s Disease (in mother)	1.0	1.1	2.9	-1.7	1.5	-0.5	0.3	0.4
Alzheimer’s Disease (in father)	0.5	0.5	1.0	0.6	1.0	-0.6	0.8	-0.5
Alzheimer’s Disease (including proxy)	0.4	0.6	1.4	-0.6	1.2	-1.0	0.4	-0.1
Crohns Disease (2017)	0.1	0.2	0.6	0.3	-0.5	0.2	-0.8	0.2
Irritable Bowel Disease (IBD)	0.3	0.7	3.4	1.8	0.4	-0.2	0.0	-0.2
Ulcerative Colitis (UC)	0.8	1.5	4.9	2.2	1.2	-0.2	0.9	0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.2	2.2	6.0	-0.4	-1.5	1.6	-2.4	0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	3.0	-0.5	0.3	0.3	1.7	0.5
Breast Cancer	1.6	3.7	8.5	1.2	-1.6	-0.2	-2.5	-2.9
Ovarian Cancer	1.4	1.8	3.6	-0.8	1.0	1.9	1.1	1.7
Prostate Cancer	3.5	4.9	13.0	-3.6	0.6	1.9	0.7	2.6
Age at First Birth	1.4	2.0	8.4	-0.0	1.1	-2.9	0.3	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.4	0.4	0.7	-0.6	-0.5	-0.2
Coronary Artery Disease (CAD)	0.4	0.5	1.5	1.2	-0.0	0.0	0.6	0.8
Crohns Disease (2012)	0.5	0.8	1.5	-1.0	-0.7	0.0	-1.0	1.2
Mean Putamen Volume	1.0	1.1	3.8	-0.2	0.3	0.4	1.2	2.0
Fasting Glucose	1.9	2.3	5.1	1.7	-1.8	2.3	-0.2	0.1
HbA1C	1.0	1.1	2.8	1.4	-0.9	-1.7	-0.0	0.1
HDL Cholesterol	0.4	0.6	2.5	0.1	-0.7	-1.6	-0.1	-0.1
LDL Cholesterol	0.5	0.8	2.7	1.6	-0.7	0.3	0.2	-0.7
Lupus	0.3	0.4	0.7	0.3	0.7	-0.7	-0.7	-0.8
Neuroticism (2016)	1.3	1.8	3.6	-1.6	-0.6	-0.7	-1.9	-1.5
Primary Biliary Cirrhosis	0.8	1.2	3.7	0.4	1.9	0.4	1.0	1.0
Rheumatoid Arthritis	0.5	0.6	1.2	-0.8	1.1	-0.4	1.0	-0.2
Schizophrenia (2014)	1.1	2.5	8.1	1.7	-0.1	2.8	-0.3	1.1
Triglycerides	0.9	1.5	6.0	0.2	-1.0	2.4	0.0	0.7
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.1	1.4	-0.5	1.4	-0.2	0.3
Ulcerative Colitis	0.6	0.9	2.5	1.6	0.5	-0.1	1.3	0.2
Blood Eosinophil Count	0.9	6.9	16.6	4.1	-2.1	0.3	1.0	-3.5
Blood Platelet Count	1.1	13.1	30.8	4.0	-3.0	1.4	2.8	-5.5
Blood Red Count	0.3	3.1	6.4	-1.3	-1.2	2.5	0.4	2.4
Blood White Count	1.0	7.3	19.9	4.5	-2.2	1.4	3.1	0.2
Heel T-Score	1.3	10.3	27.8	-1.5	3.9	-0.7	2.4	5.3
BMI	1.3	7.7	19.3	1.1	-4.4	0.5	-3.2	-2.8
Height	0.1	2.6	3.9	1.9	-1.2	-2.0	1.6	1.3
Waist Hip Ratio (WHR)	0.2	1.1	2.4	0.7	0.0	1.4	-1.5	-0.7
Systolic Blood Pressure	1.3	6.5	10.6	3.1	0.2	-3.2	2.1	-2.8
Smoking Status	0.7	1.6	3.3	1.5	-1.8	0.0	-1.5	-0.5
Allergy or Eczema	0.4	1.2	5.5	-0.4	-0.1	2.3	-0.1	-0.4
Cardiovascular Disease	1.0	3.2	4.7	1.8	-1.8	-2.1	0.6	-2.2
Hypothyroidism (self reported)	0.5	1.0	4.4	-0.2	0.3	0.2	2.1	0.8
Respiratory disease	0.4	0.9	3.3	0.6	0.7	0.4	1.8	-0.3
Type 2 Diabetes (T2D) (2018)	1.1	2.1	5.9	-0.3	-1.9	0.9	-0.2	-2.4
Lung FEV1/FVC ratio	0.6	3.3	7.5	0.1	-2.7	-0.3	-2.5	-1.6
Lung FVC	0.3	1.8	3.1	-0.0	-1.3	-1.7	-1.1	-1.8
Neuroticism	1.3	3.2	8.6	-0.9	-1.6	0.2	-2.9	-2.1
Chronotype (morning person)	1.7	3.9	7.8	2.1	-2.8	-1.9	-1.8	0.8
Hair Pigment	0.2	4.7	20.0	-1.3	4.5	1.2	0.5	0.1
Tanning	0.3	3.5	6.6	2.3	1.2	-1.6	2.6	1.1
Hand grip strength (left)	0.7	1.9	6.7	1.3	0.5	-2.6	0.9	0.1
Number of treatments/medications taken	2.0	3.6	12.2	-0.0	-2.0	-1.1	-0.6	-3.5
Average weekly spirits intake	1.6	1.9	9.1	-0.1	-0.7	0.4	0.1	3.0
Sensitivity / hurt feelings	0.6	1.0	1.9	-0.9	0.8	0.5	-1.3	-1.4
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.9	-0.3	-2.0	-0.1	-1.1	-1.6
Hearing difficulty/problems: Yes	0.2	0.4	1.1	0.0	-0.8	1.1	0.0	-0.2
Relative age of first facial hair	0.9	1.8	3.2	-1.8	0.8	1.8	-0.3	1.3
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.1	0.2	-1.5	1.2	-0.4	0.2
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.7	-1.6	-1.1	1.3	-0.4	-1.4
Ever had hysterectomy (womb removed)	1.0	1.1	2.4	-1.5	-1.0	0.1	1.1	1.1
Systolic blood pressure, automated reading	0.9	2.6	6.8	2.6	-0.1	-0.7	1.2	-2.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.8	-0.2	1.3	-0.1	0.2	-1.2
Angina	1.5	2.0	6.7	1.3	-1.2	-0.0	2.6	-0.4
Medication for hormone replacement therapy	1.1	1.2	3.7	-0.1	-1.3	-0.7	0.2	-1.9
Vitamin and mineral supplements	0.6	0.8	3.0	0.5	-0.7	-1.7	-0.2	0.3
Supplements: Zinc	0.5	0.5	1.3	-1.1	0.6	0.7	0.5	-0.1
Medication: Co-codamol	1.9	2.2	3.6	-0.7	-1.7	1.9	-1.3	-1.6
Medication: Metformin	1.4	1.9	3.3	-1.7	-1.4	0.6	-1.1	-1.8
Diabetes (father)	0.9	1.1	1.8	1.1	-1.2	0.6	-1.4	-0.8
Diabetes (mother)	1.0	1.3	3.2	-0.3	-1.8	1.4	0.1	-1.1
Severe depression (siblings)	0.1	0.2	0.4	-0.0	-0.6	0.4	-0.1	-0.5
Pack years adult smoking proportion	0.4	0.6	1.4	-0.8	-1.2	0.5	-0.8	0.0
Impedance of leg (right)	2.1	10.2	22.1	-1.1	4.7	0.6	3.3	4.1
Leg fat-free mass (left)	1.1	5.6	16.5	1.7	-4.1	0.4	-2.2	-1.9
Trunk fat percentage	0.4	1.6	7.5	-0.5	0.1	2.7	-0.5	-0.0
Hand grip strength (right)	0.4	1.1	2.7	1.0	0.1	-1.7	1.1	0.8
Townsend deprivation index at recruitment	1.2	1.6	3.8	-0.1	-1.9	1.0	-0.9	-1.6
Current tobacco smoking	0.4	0.6	1.3	0.2	-0.7	1.0	0.2	1.1
Average weekly fortified wine intake	1.3	1.5	2.9	-1.1	-1.3	-0.7	-1.1	1.7
Maternal smoking around birth	0.3	0.5	1.4	0.3	-1.2	0.1	0.9	-0.3
Fed-up feelings	0.2	0.3	0.6	-0.7	0.3	0.8	-0.6	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.1	4.5	-2.1	-0.7	0.9	-1.1	-1.8
Relative age voice broke	0.8	1.2	2.8	-1.7	-0.5	0.6	-1.6	0.5
Taking other prescription medications	2.5	3.8	13.5	-0.2	-1.8	-1.2	-1.0	-3.7
Age when periods started (menarche)	0.3	0.7	2.7	0.2	0.8	0.1	0.1	-1.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.1	-0.8	-1.4	0.1	-0.9	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	2.9	1.7	0.3	-1.1	1.4	1.5
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	4.7	2.2	0.5	-1.3	0.9	0.4
Qualifications: CSEs or equivalent	0.2	0.2	0.5	-0.6	0.5	0.3	0.2	-0.7
Serious illness, injury or assault to yourself	1.3	1.6	2.6	-0.6	-1.5	1.6	-1.6	-0.5
High blood pressure	0.7	2.0	5.0	1.2	-1.0	-1.6	0.3	-2.2
Hayfever, allergic rhinitis or eczema	0.5	1.2	5.2	0.0	0.7	2.3	0.2	-0.4
Multivitamins +/- minerals	1.5	1.8	4.0	0.5	1.1	2.0	1.1	-1.6
Stomach or abdominal pain in last month	0.4	0.5	1.0	1.0	-0.0	0.9	0.7	0.4
Supplements: Glucosamine	0.7	0.9	3.1	0.2	0.2	0.5	-0.9	-1.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.7	-0.4	-0.7	-0.6	-0.8	0.3
Medication: Atenolol	0.4	0.5	1.5	-0.0	-0.6	-1.2	0.6	-0.5
Medication: Levothyroxine sodium	1.7	2.8	12.3	0.4	1.2	0.0	3.5	0.2
Sitting height	0.1	0.5	1.3	0.9	-1.1	0.3	0.6	0.0
Chronic bronchitis/emphysema (father)	1.9	2.2	5.7	-1.7	1.1	2.4	0.6	0.8
High blood pressure (mother)	0.5	0.7	2.3	0.8	-0.5	-0.0	0.7	-1.5
Body mass index (BMI)	1.0	4.1	9.6	0.3	-3.1	1.5	-2.3	-1.8
Impedance of leg (left)	2.3	10.9	24.6	-1.2	5.0	0.8	3.8	3.6
Leg predicted mass (left)	1.0	5.2	15.4	1.6	-3.9	0.3	-2.1	-1.9
Trunk fat mass	0.4	1.7	5.8	-0.1	-1.2	2.4	-0.8	-0.5
Waist circumference	1.4	5.3	10.7	0.7	-3.3	2.1	-2.8	-1.8
Number of incorrect matches in round	0.5	0.9	2.5	0.5	1.2	-0.4	-0.2	1.6
Past tobacco smoking	0.6	1.1	3.8	-1.9	-0.0	-0.9	-1.1	0.1
Alcohol usually taken with meals	0.4	0.6	1.5	-0.0	-1.1	0.3	0.5	1.2
Nervous feelings	0.8	1.6	4.8	-0.6	1.4	0.9	0.2	2.2
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	6.8	-1.8	-1.6	-0.9	-1.9	-2.6
Hearing difficulty/problems with background noise	1.6	2.6	6.2	-0.4	-1.9	1.3	-1.2	-2.5
Hair/balding pattern: Pattern 2	1.2	1.6	6.4	-0.5	-0.8	-0.1	-0.8	-2.5
Had menopause	2.3	2.8	5.8	-2.1	0.5	0.6	-2.4	-1.8
Had other major operations	0.8	1.0	1.9	-0.9	-0.8	1.4	-1.3	0.2
Forced vital capacity (FVC)	0.1	0.3	1.1	0.4	0.0	-1.0	0.2	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.9	1.1	-0.1	-0.4	0.9	1.4
Ever unenthusiastic/disinterested for a whole week	2.5	3.1	7.7	-2.2	-1.6	-0.3	-2.8	-0.1
Qualifications: None of the above	0.4	0.9	3.7	-0.4	-0.3	0.4	-0.4	-1.9
Financial difficulties in last 2 years	0.5	0.6	1.8	0.2	-1.3	0.8	0.7	0.0
Mouth/teeth dental problems	0.3	0.5	2.5	0.1	0.0	-1.6	-0.3	0.0
Heart attack	0.9	1.2	2.9	0.9	0.9	-1.2	1.7	-0.1
Allergy	1.1	2.4	9.7	0.0	-1.3	-3.1	-0.7	0.5
Pain all over the body in last month	3.4	3.6	5.9	-1.2	-2.4	1.7	-1.5	-2.4
Diabetes (self-reported)	1.2	1.9	4.0	-1.2	-1.5	0.9	-1.0	-2.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.3	0.6	-0.5	0.9	0.5	-1.1
Medication: Ramipril	0.9	1.1	1.9	1.4	-0.9	-1.0	-0.8	-1.1
Medication: Simvastatin	0.6	0.9	2.6	-0.3	-1.0	-0.8	1.6	-0.5
Fluid intelligence score	0.1	0.2	0.4	-0.7	0.1	-0.3	0.6	0.3
Illnesses of siblings	1.2	1.7	7.3	-0.3	0.6	-0.7	0.3	2.7
Neuroticism score	0.4	0.9	2.5	-1.0	-0.2	0.1	-1.6	-0.8
Weight	0.8	3.8	12.3	0.9	-3.5	1.4	-1.6	-1.2
Impedance of arm (right)	2.6	12.1	34.0	-2.1	5.8	0.7	3.0	3.5
Arm fat percentage (right)	0.5	1.8	6.1	-0.6	-1.0	2.5	-1.2	-0.2
Trunk fat-free mass	1.1	6.4	25.6	1.4	-5.1	-0.1	-1.8	-1.1
Hip circumference	0.8	3.6	10.4	0.8	-3.2	1.4	-1.8	-1.3
Time employed in main current job	0.6	0.7	2.9	-0.1	-0.8	-1.7	0.3	-0.1
Alcohol intake versus 10 years previously	0.0	0.0	0.1	0.1	0.3	-0.0	-0.2	-0.3
Father’s age at death	0.1	0.2	0.7	0.3	-0.2	-0.2	-0.9	0.0
Worrier / anxious feelings	0.3	0.5	1.5	-0.7	1.2	-0.6	-0.2	0.3
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	4.5	-0.8	-1.5	2.1	-0.2	-1.8
Falls in the last year	2.3	3.1	7.6	-1.2	-2.7	2.3	-0.0	-0.9
Hair/balding pattern: Pattern 3	1.0	1.5	2.6	1.3	-0.8	1.5	0.3	1.6
Number of live births	1.8	2.5	5.7	-1.4	-0.4	2.4	0.3	2.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	0.9	0.7	-0.7	-0.8	-0.1	-1.0
Pulse rate	1.1	1.9	7.6	-1.0	-0.3	-0.4	-2.8	-0.7
Happiness	0.6	0.7	2.3	-0.4	-0.9	-0.3	-0.4	1.5
Noisy workplace	0.7	0.8	2.6	-0.6	-1.6	-0.3	-0.2	1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.8	1.1	-1.3	-0.1	-0.6	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.3	1.0	-0.2	-1.5	-0.4	1.0
Mouth/teeth dental problems: Dentures	0.5	0.8	1.4	0.2	0.7	1.1	1.2	0.9
Asthma	0.4	0.8	2.7	-0.0	-0.8	1.6	0.4	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.6	-1.3	0.2	-1.2	-0.3	-0.6
Medication: Cholesterol lowering	0.9	1.4	2.9	-0.4	-0.8	-1.7	1.2	-1.3
Depression (self-reported)	1.7	2.1	4.2	-0.3	-2.1	-0.1	-2.0	-1.4
Medication: Lansoprazole	0.4	0.4	1.5	-0.7	0.3	-0.1	1.2	0.2
Prospective memory result	0.5	0.6	1.3	-0.1	1.0	0.4	0.5	-1.2
Lung cancer (father)	2.1	2.5	6.9	1.6	0.4	-2.6	0.9	-1.4
Illnesses of mother	0.6	0.8	2.1	0.5	1.5	-0.1	0.6	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.3	1.1	-0.6	-0.7	-0.1	-0.8
Pulse wave Arterial Stiffness index	1.2	1.4	4.0	-1.2	-0.6	2.0	-1.0	0.0
Impedance of arm (left)	1.9	8.6	24.1	-1.3	4.9	0.2	2.7	3.2
Arm fat mass (right)	0.7	3.0	6.4	-0.3	-2.5	2.1	-1.9	-0.8
Trunk predicted mass	1.1	6.5	26.3	1.3	-5.1	-0.1	-1.8	-1.0
Standing height	0.1	1.4	2.0	1.4	-1.1	0.4	1.2	1.3
Length of working week for main job	0.6	0.6	1.8	-0.6	-0.1	-1.4	-0.2	-0.9
Exposure to tobacco smoke at home	0.7	0.8	3.0	-0.1	-1.0	-0.0	0.2	-1.7
Breastfed as a baby	0.4	0.5	1.8	1.3	-0.4	0.3	0.8	-0.2
Tense / ‘highly strung’	0.4	0.7	2.2	-0.6	-1.0	0.3	-1.5	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	4.4	6.8	14.0	-1.9	-2.7	0.9	-2.8	-3.7
Hair/balding pattern: Pattern 4	0.3	0.6	2.4	-0.4	-1.6	-0.6	-0.1	0.2
Birth weight of first child	0.1	0.2	0.5	-0.7	-0.3	-0.2	0.1	0.5
Peak expiratory flow (PEF)	0.2	0.5	1.2	0.3	-1.1	-0.1	0.9	0.5
Pulse wave reflection index	1.6	2.0	9.1	-3.0	0.2	0.3	-0.4	0.7
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.1	-1.1	1.0	1.0	0.7	-0.8
Loud music exposure frequency	1.7	1.9	3.0	1.3	1.5	-1.6	1.7	0.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	3.0	0.7	-0.0	-1.7	-0.8	-0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.5	0.1	-0.3	0.7	-0.5	0.2
Blood clot in the leg (DVT)	1.2	1.5	4.9	-1.5	-0.7	2.2	-0.2	0.1
Medication: Paracetamol	0.9	1.5	5.5	0.8	0.3	-1.2	0.2	-2.4
Headache pain in last month	1.7	3.0	7.3	0.1	1.3	1.5	1.9	2.7
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	8.0	-0.0	1.2	1.5	0.1	2.8
Glaucoma (self-reported)	0.2	0.2	1.1	0.1	0.1	0.1	0.3	-1.1
Gout (self-reported)	0.4	0.5	1.5	-1.2	0.1	-1.0	-0.3	0.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	6.2	0.2	0.5	0.4	2.5	0.3
Medication: Amlodipine	0.5	0.7	1.5	-0.4	-0.5	-1.1	-0.5	-1.2
Medication: Ventolin 100micrograms inhaler	1.1	1.5	2.3	1.5	-1.5	0.2	-1.3	-1.0
Birth weight	0.7	1.6	3.5	1.3	0.2	-1.3	-0.8	-1.9
Chronic bronchitis/emphysema (mother)	0.9	1.0	1.8	0.9	-1.3	0.6	-1.3	-0.8
High blood pressure (siblings)	1.2	1.8	6.0	0.4	-1.1	-0.8	-1.1	-2.5
Forced vital capacity (FVC), Best measure	0.1	0.2	0.7	0.8	0.1	-0.6	0.3	0.0
Body fat percentage	0.4	1.7	7.7	-0.5	-0.3	2.8	-0.6	0.1
Leg fat percentage (right)	0.4	1.3	3.1	-0.7	-1.3	1.8	-1.1	-0.2
Arm fat-free mass (right)	1.3	6.9	23.4	1.7	-4.8	0.3	-2.0	-1.9
Exposure to tobacco smoke outside home	1.5	2.0	6.5	0.7	-0.0	-0.6	2.6	-1.6
Comparative body size at age 10	0.9	2.5	4.6	0.7	-2.1	-1.7	-1.5	-1.6
Number of full brothers	1.4	1.8	4.9	-0.6	-1.4	2.2	-0.6	1.1
Worry too long after embarrassment	0.5	0.8	3.3	0.0	0.3	-0.7	-0.3	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.0	1.4	-0.5	1.1	0.7	-0.5
Wheeze or whistling in the chest in last year	0.8	1.4	5.3	-0.4	-1.0	2.3	0.4	-0.7
Number of children fathered	0.1	0.1	0.5	-0.1	0.3	-0.2	0.1	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	3.0	0.1	1.1	-0.5	-1.7	0.7
Age at first live birth	0.5	0.9	1.8	1.3	-0.1	-1.1	-0.7	1.0
Pulse wave peak to peak time	1.4	1.6	4.8	1.3	0.7	-2.2	1.0	-0.2
Health satisfaction	0.2	0.2	1.0	-1.0	-0.4	0.0	-0.2	0.0
Shortness of breath walking on level ground	0.8	0.9	3.1	1.1	-0.3	-0.3	-0.4	-1.7
Qualifications: College or University degree	0.4	1.3	2.4	1.5	-1.4	-0.9	-0.8	1.0
Eye problems/disorders: None of the above	1.1	1.2	2.3	1.5	-0.6	-1.4	0.9	0.9
Mouth/teeth dental problems: Loose teeth	2.2	2.6	6.1	-1.3	-1.7	0.4	-2.5	-1.4
Emphysema/chronic bronchitis	1.4	1.6	4.4	0.6	1.0	1.3	2.1	-0.5
Medication for pain relief, constipation, heartburn	0.5	0.9	3.2	1.2	-0.0	-0.2	-0.0	1.8
Neck or shoulder pain in last month	1.6	2.3	5.1	1.6	-0.5	-0.5	1.8	-2.3
Medication: Blood pressure	1.6	2.8	7.4	0.7	-1.9	-1.4	-0.8	-2.7
Angina (self-reported)	1.5	2.0	6.1	1.4	-1.3	0.2	2.5	-0.2
Migraine (self-reported)	0.5	0.7	1.7	-0.6	1.0	-0.2	1.3	0.2
Medication: Ibuprofen	0.5	0.6	1.1	-1.1	0.1	-0.9	-0.7	-0.8
Medication: Allopurinol	0.5	0.6	1.4	-1.2	-0.8	-0.2	-0.8	-0.7
Medication: Omeprazole	1.7	2.1	7.4	-1.1	0.3	2.7	-1.3	-0.2
Medication: Seretide 50 evohaler	0.6	0.7	2.8	0.3	1.7	-0.2	-0.5	-0.8
Mean time to correctly identify matches	1.3	2.5	6.8	-1.2	-1.8	0.9	-2.6	-0.6
Heart disease (mother)	0.1	0.1	0.2	0.4	-0.1	0.3	-0.4	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.8	-0.7	-0.8	-0.2	0.2	-1.7
Whole body fat mass	0.5	2.0	5.7	0.1	-1.6	2.4	-1.1	-0.6
Leg fat mass (right)	0.5	2.1	4.7	0.3	-2.2	1.6	-1.4	-1.0
Arm predicted mass (right)	1.5	7.7	26.4	1.7	-5.1	0.3	-2.2	-2.1
Pulse rate, automated reading	0.4	1.3	3.3	-0.2	0.3	1.1	-1.4	1.8
Alcohol intake frequency.	0.5	1.2	2.1	-1.2	-1.5	0.7	0.7	1.3
Comparative height size at age 10	0.3	1.5	4.0	0.7	0.4	0.5	1.6	2.0
Number of full sisters	0.5	0.7	1.7	-0.6	-0.4	1.0	-1.3	0.3
Suffer from ‘nerves’	1.5	2.3	4.1	-2.0	-0.7	2.0	-1.3	0.9
Overall health rating	0.9	2.0	4.7	-1.6	-1.2	2.2	0.3	1.2
Chest pain or discomfort	1.5	2.1	8.1	0.2	-2.9	-0.5	-0.4	-1.4
Had major operations	1.3	1.6	5.7	-0.6	-1.0	2.4	0.2	0.8
Age at last live birth	0.7	1.1	2.3	-1.1	-1.4	0.3	-1.5	0.1
Family relationship satisfaction	0.2	0.3	0.7	-0.6	-0.3	-0.8	0.0	0.5
Leg pain on walking	1.9	2.4	5.7	-0.3	-1.6	2.4	-1.1	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.2	-1.2	1.5	0.3	0.6	-0.5
Commuting to job workplace: Car/motor vehicle	0.9	1.0	3.5	-0.0	0.5	-1.0	0.7	-1.9
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	4.2	0.6	2.1	-2.0	1.1	-0.7
Medication: Aspirin	1.4	1.8	8.0	-0.4	0.4	0.6	2.8	0.6
Supplements: Vitamin C	0.1	0.1	0.2	0.3	0.4	0.3	0.1	-0.3
Knee pain experienced in last month	1.1	1.8	5.8	0.1	-2.4	0.8	-0.9	-1.2
Hypertension (Self-reported)	0.7	1.9	3.8	0.8	-1.1	-1.8	0.4	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	4.6	-1.2	-0.5	0.0	-2.1	-0.6
Illnesses of father: Heart disease	0.7	1.0	2.1	1.2	-0.4	-1.0	1.4	-0.6
Illnesses of siblings: Diabetes	0.5	0.6	2.1	0.3	-0.1	0.2	0.9	-1.5
Smoking status: Previous	0.4	0.6	2.5	1.6	-0.0	0.5	-0.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.2	1.1	-0.4	-0.2	-0.3	1.1
Whole body fat-free mass	1.1	6.3	22.6	1.6	-4.8	0.1	-2.0	-1.5
Leg fat-free mass (right)	1.0	5.4	15.8	1.7	-4.0	0.5	-1.9	-2.2
Arm fat percentage (left)	0.5	1.9	4.5	-0.2	-1.5	2.1	-1.5	-0.5
Average weekly red wine intake	1.5	2.3	5.4	2.3	0.4	0.2	2.1	1.2
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.9	-0.8	-0.6	-1.1	-1.7	-2.0
Mood swings	0.1	0.3	0.5	0.6	-0.5	0.1	-0.7	-0.4
Loneliness, isolation	1.4	1.9	4.0	-1.3	-1.8	2.0	-0.7	-0.2
Long-standing illness, disability or infirmity	1.4	2.2	7.9	-0.6	-2.8	1.5	-0.3	-0.5
Ever had bowel cancer screening	1.8	2.2	6.0	-0.9	-0.8	0.4	-1.8	-2.5
Diabetes diagnosed by doctor	1.2	2.0	3.9	-0.6	-1.6	1.2	-1.2	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	4.4	-0.2	2.1	-0.6	1.1	-1.6
Friendships satisfaction	0.6	0.7	2.0	1.4	-0.9	-0.0	-0.6	0.5
Qualifications: nursing, teaching	0.1	0.2	0.9	-0.1	-0.3	-0.1	-0.1	-0.9
Commuting to job workplace: Walk	1.0	1.0	1.8	-1.1	-0.6	1.3	0.6	1.3
Eye problems/disorders: Cataract	0.4	0.5	1.6	-0.3	0.6	0.5	-1.3	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	4.4	0.4	-0.5	-1.1	-0.1	-2.1
Medication for cholesterol	0.7	1.0	1.8	-0.3	1.3	1.1	-0.9	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	7.4	0.3	-2.7	0.0	-1.6	-1.5
Back pain experienced in last month	1.1	1.6	5.7	-1.3	-2.4	0.6	0.3	-0.6
Mineral and other dietary supplements	0.4	0.6	1.1	-0.5	-1.0	0.7	-0.2	1.0
Breast cancer (self-reported)	0.8	0.9	2.1	-0.3	0.8	1.4	-1.2	-0.4
Asthma (self-reported)	0.3	0.6	1.3	-0.2	-0.9	1.2	0.4	-0.7
Osteoporosis (self-reported)	0.6	0.7	1.8	0.2	1.2	0.3	1.4	0.5
Osteoarthritis (self-reported)	0.6	0.8	1.8	-0.9	-0.8	1.3	-0.7	0.2
Medication: Aspirin	1.3	1.7	6.7	-0.6	0.1	0.7	2.6	0.9
Medication: Gliclazide	3.7	4.2	11.3	1.0	-3.4	1.0	-2.1	-1.9
Illnesses of father: None of the above (group 1)	0.6	0.8	3.3	-0.4	-0.2	0.1	-1.8	0.5
Smoking status: Current	0.2	0.4	1.0	0.2	-0.9	0.2	0.0	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	5.6	0.4	-0.3	-2.4	-1.9	-1.5
Whole body water mass	1.1	6.2	21.9	1.5	-4.7	0.2	-2.0	-1.7
Leg predicted mass (right)	1.0	5.3	14.9	1.7	-3.9	0.5	-1.8	-2.2
Arm fat mass (left)	0.8	3.4	7.1	-0.2	-2.7	2.2	-2.0	-0.9
Number of self-reported non-cancer illnesses	1.9	3.3	8.6	1.2	-2.4	-0.7	0.5	-2.9
Average weekly champagne plus white wine intake	1.6	2.2	7.9	-0.4	-1.0	-2.8	-1.0	-1.0
Miserableness	0.1	0.3	0.8	-0.5	0.4	0.9	-0.1	0.2
Guilty feelings	1.9	2.8	7.3	-1.2	-1.1	-0.7	-1.9	-2.7
Wears glasses or contact lenses	0.2	0.3	0.8	0.4	0.2	-0.9	-0.0	-0.6
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.4	-0.4	0.5	-0.4	-0.6
Hearing aid user	1.2	1.3	3.2	-1.8	0.8	0.6	1.2	1.0
Mother’s age at death	1.0	1.2	4.0	-2.0	0.0	1.3	0.1	-0.7
Financial situation satisfaction	0.9	1.1	5.0	0.1	-0.6	-2.2	0.2	0.1
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.1	0.8	1.4	-0.1	1.8	1.1
Commuting to job workplace: Public transport	0.5	0.6	1.3	1.0	-0.3	0.1	-0.6	1.2
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	-0.9	0.8	-1.0	0.3	-0.7
Medication: Blood pressure	0.8	1.4	4.1	0.5	-0.5	-1.6	2.0	-0.4
Pain type(s) experienced in last month: Hip pain	1.5	1.9	4.9	0.3	-1.3	1.6	-0.6	-2.2
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.1	0.6	0.8	0.6	1.1	0.6
High cholesterol (Self-reported)	1.0	1.8	5.5	-0.7	-2.4	-1.5	-0.1	-0.9
Medication: Bendroflumethiazide	1.2	1.8	7.1	-0.1	-1.0	-2.7	0.2	-1.0
Medication: Paracetamol	0.5	0.8	3.3	0.3	-0.4	-0.6	-0.5	-1.8
Medication: Lisinopril	0.9	1.2	3.5	0.2	0.9	-1.9	1.2	-0.1
Medication: Atorvastatin	0.8	1.0	1.8	-0.8	-1.4	-1.3	0.3	-0.8
Illnesses of father: High blood pressure	0.8	1.0	2.7	-0.0	0.7	-1.7	1.1	-0.8
Alcohol drinker status: Never	1.7	2.1	7.3	-0.0	-1.4	-2.7	0.3	-1.0
Ever smoked	1.8	3.1	5.2	2.1	0.3	2.3	2.3	0.8
Basal metabolic rate	1.0	5.6	20.2	1.4	-4.5	0.5	-1.9	-1.4
Leg fat percentage (left)	0.5	1.7	4.9	-0.9	-1.2	2.2	-1.0	-0.4
Arm fat-free mass (left)	1.0	5.2	18.6	1.2	-4.3	0.6	-1.7	-1.6
Number of operations (self-reported)	2.3	3.3	5.6	-2.4	-1.8	1.9	-1.6	-1.3
Average weekly beer plus cider intake	0.8	1.1	3.6	0.1	1.9	0.2	1.3	0.5
Irritability	1.5	2.5	5.8	-0.8	-1.9	0.7	-1.4	-2.4
Risk taking	1.2	1.7	5.7	-0.9	-2.4	-0.2	-1.4	0.5
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.5	0.2	0.9	1.2	0.6	1.1
Fractured/broken bones in last 5 years	1.7	2.2	6.5	0.0	-1.1	-0.0	-1.8	-2.6
Age started oral contraceptive pill	0.7	0.9	2.2	-0.4	-0.7	-1.0	-1.5	-0.8
Diastolic blood pressure, automated reading	0.1	0.3	0.5	0.7	-0.3	-0.4	-0.4	0.6
Ever depressed for a whole week	1.2	1.5	3.2	-1.2	-1.8	-0.2	-1.7	0.2
Unable to work because of sickness or disability	2.0	2.5	5.6	-2.4	-1.8	1.7	-1.0	-0.4
Commuting to job workplace: Cycle	0.5	0.6	1.7	1.3	-0.7	0.4	-0.8	0.3
Myopia	0.4	0.6	1.0	0.4	0.8	-1.0	0.4	0.9
Vascular/heart problems diagnosed by doctor	1.1	2.9	7.8	-1.3	0.9	1.9	-0.7	2.8
Cholesterol lowering medication	0.4	0.5	1.7	-0.5	-1.3	-0.8	0.4	0.0
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	5.4	-1.1	0.4	2.3	-1.0	-0.2
Pain experienced in last month	1.0	1.7	5.3	0.0	2.3	-1.0	-0.0	1.5
Supplements: Calcium	1.4	1.5	5.1	-2.3	1.1	-1.0	0.1	0.4
Basal cell carcinoma (self-reported)	0.4	0.5	1.2	1.1	-0.5	0.6	0.7	-0.2
Heart attack/myocardial infarction (self-reported)	1.1	1.4	4.0	1.0	0.9	-1.2	2.0	0.0
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	6.0	-1.6	-0.4	2.5	-0.3	0.2
Heart disease (siblings)	1.9	2.3	5.2	0.3	-2.3	0.6	-0.7	-2.3
Alcohol drinker status: Previous	1.5	1.7	3.1	-1.7	-1.2	-1.8	-1.1	-0.6
Pack years of smoking	0.4	0.5	1.5	-0.5	-1.2	0.2	-0.8	-0.2
Impedance of whole body	2.4	12.2	31.8	-1.4	5.6	0.5	3.5	3.8
Leg fat mass (left)	0.7	2.6	5.2	0.2	-2.3	2.0	-1.5	-1.3
Arm predicted mass (left)	1.2	5.9	20.8	1.0	-4.6	0.8	-2.0	-1.7