Best TWAS P=1.11e-13 · Best GWAS P=3.44e-13 conditioned to 0.000112
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | BAIAP2L2 | 0.11 | 0.03 | lasso | 5 | 0.04 | 1.8e-04 | 4.7 | -7.1 | 1.7e-12 | -0.73 | 0.01 | 0.94 | FALSE |
2 | GTEx | Artery Aorta | TMEM184B | 0.17 | 0.07 | enet | 34 | 0.03 | 1.2e-02 | 5.8 | -5.2 | 1.8e-07 | -0.19 | 0.06 | 0.71 | FALSE |
3 | GTEx | Artery Aorta | AL021977.1 | 0.13 | 0.00 | enet | 17 | 0.01 | 8.7e-02 | 6.9 | -5.3 | 9.8e-08 | -0.30 | 0.03 | 0.74 | FALSE |
4 | GTEx | Brain Cortex | TMEM184B | 0.29 | 0.12 | lasso | 7 | 0.09 | 1.6e-03 | 5.8 | -5.4 | 5.3e-08 | -0.34 | 0.03 | 0.78 | FALSE |
5 | GTEx | Cells EBV-transformed lymphocytes | PLA2G6 | 0.28 | 0.17 | enet | 13 | 0.18 | 1.3e-06 | -4.4 | 5.3 | 9.3e-08 | 0.23 | 0.15 | 0.77 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | PLA2G6 | 0.23 | 0.09 | lasso | 9 | 0.10 | 9.9e-08 | 4.6 | 5.2 | 1.8e-07 | 0.21 | 0.20 | 0.80 | FALSE |
7 | GTEx | Nerve Tibial | PLA2G6 | 0.34 | 0.08 | lasso | 8 | 0.11 | 2.9e-08 | -4.4 | 5.1 | 2.6e-07 | 0.20 | 0.11 | 0.89 | FALSE |
8 | GTEx | Nerve Tibial | MAFF | 0.14 | 0.06 | lasso | 3 | 0.05 | 1.2e-04 | 7.1 | -6.8 | 1.0e-11 | -0.38 | 0.01 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PLA2G6 | 0.05 | 0.01 | blup | 76 | 0.01 | 7.7e-02 | 5.9 | 7.4 | 1.1e-13 | 0.54 | 0.02 | 0.64 | TRUE |
10 | The Cancer Genome Atlas | Thyroid Carcinoma | PLA2G6 | 0.03 | 0.02 | lasso | 2 | 0.03 | 6.5e-04 | 5.7 | 5.6 | 2.2e-08 | 0.33 | 0.08 | 0.30 | FALSE |