Best TWAS P=1.22e-10 · Best GWAS P=4.61e-10 conditioned to 0.0161
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Esophagus Gastroesophageal Junction | SFI1 | 0.15 | 0.07 | lasso | 3 | 0.06 | 3.7e-03 | -6.1 | 6.4 | 1.6e-10 | -0.93 | 0.02 | 0.88 | FALSE |
2 | GTEx | Esophagus Mucosa | SFI1 | 0.13 | 0.11 | lasso | 6 | 0.10 | 3.9e-07 | -5.0 | 5.2 | 2.1e-07 | -0.80 | 0.83 | 0.17 | FALSE |
3 | GTEx | Esophagus Muscularis | LIMK2 | 0.08 | 0.03 | lasso | 4 | 0.01 | 4.3e-02 | -6.1 | 5.9 | 2.7e-09 | -0.84 | 0.03 | 0.92 | FALSE |
4 | GTEx | Heart Left Ventricle | SFI1 | 0.12 | 0.10 | enet | 20 | 0.07 | 2.3e-04 | 5.1 | 5.4 | 7.1e-08 | -0.67 | 0.07 | 0.92 | FALSE |
5 | GTEx | Muscle Skeletal | SFI1 | 0.13 | 0.09 | enet | 22 | 0.10 | 1.7e-10 | 5.1 | 6.4 | 1.2e-10 | -0.70 | 0.44 | 0.56 | TRUE |
6 | GTEx | Nerve Tibial | SFI1 | 0.23 | 0.06 | enet | 16 | 0.14 | 1.9e-10 | -4.6 | 5.6 | 2.6e-08 | -0.75 | 0.27 | 0.72 | FALSE |
7 | GTEx | Thyroid | SFI1 | 0.12 | 0.10 | lasso | 12 | 0.11 | 1.4e-08 | -5.0 | 5.4 | 6.8e-08 | -0.79 | 0.49 | 0.51 | FALSE |
8 | NTR | Blood | DEPDC5 | 0.02 | 0.02 | lasso | 5 | 0.01 | 2.4e-05 | -6.0 | 6.2 | 4.5e-10 | -0.60 | 0.00 | 1.00 | FALSE |
9 | NTR | Blood | PISD | 0.05 | 0.08 | lasso | 5 | 0.09 | 3.3e-27 | -6.0 | 5.4 | 7.6e-08 | -0.52 | 0.02 | 0.98 | FALSE |
10 | YFS | Blood | PISD | 0.36 | 0.32 | lasso | 9 | 0.35 | 5.1e-122 | -6.0 | 5.7 | 1.6e-08 | -0.64 | 0.01 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Colon Adenocarcinoma | RNF185 | 0.08 | 0.05 | blup | 54 | 0.08 | 1.8e-05 | -6.2 | -5.4 | 7.2e-08 | 0.85 | 0.01 | 0.98 | FALSE |
12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LIMK2 | 0.06 | 0.06 | blup | 47 | 0.06 | 9.3e-08 | -5.0 | 5.8 | 5.6e-09 | -0.91 | 0.07 | 0.93 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RNF185 | 0.06 | 0.05 | blup | 54 | 0.05 | 4.7e-06 | -6.0 | -5.2 | 2.1e-07 | 0.82 | 0.00 | 0.99 | FALSE |
14 | The Cancer Genome Atlas | Rectum Adenocarcinoma | RNF185 | 0.18 | 0.10 | enet | 6 | 0.12 | 9.7e-04 | -6.0 | -5.9 | 3.1e-09 | 0.95 | 0.00 | 0.86 | FALSE |
15 | The Cancer Genome Atlas | Thyroid Carcinoma | RNF185 | 0.06 | 0.09 | lasso | 4 | 0.07 | 1.5e-07 | -6.2 | -6.2 | 6.2e-10 | 1.00 | 0.00 | 1.00 | FALSE |
16 | The Cancer Genome Atlas | Thyroid Carcinoma | SELM | 0.04 | 0.00 | blup | 54 | 0.01 | 4.8e-02 | -4.2 | 5.3 | 1.2e-07 | -0.68 | 0.02 | 0.63 | FALSE |