Best TWAS P=1.94e-18 · Best GWAS P=3.82e-19 conditioned to 0.00208
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ECE2 | 0.24 | 0.20 | bslmm | 542 | 0.19 | 1.6e-22 | -7.4 | -7.2 | 7.4e-13 | -0.34 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Brain Putamen basal ganglia | ECE2 | 0.38 | 0.03 | enet | 22 | 0.11 | 1.4e-03 | -7.4 | -6.9 | 6.5e-12 | -0.28 | 0.07 | 0.23 | FALSE |
| 3 | GTEx | Esophagus Mucosa | ABCF3 | 0.11 | 0.10 | lasso | 3 | 0.08 | 3.6e-06 | 6.3 | -6.4 | 1.2e-10 | -0.26 | 0.59 | 0.28 | FALSE |
| 4 | GTEx | Heart Left Ventricle | DVL3 | 0.18 | 0.13 | enet | 5 | 0.11 | 1.8e-06 | -4.9 | -5.3 | 1.3e-07 | -0.25 | 0.96 | 0.00 | FALSE |
| 5 | GTEx | Pituitary | ECE2 | 0.52 | 0.30 | lasso | 7 | 0.23 | 1.5e-06 | -7.4 | -6.1 | 1.4e-09 | -0.28 | 0.35 | 0.31 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | ABCF3 | 0.15 | 0.10 | lasso | 4 | 0.11 | 1.1e-06 | -6.6 | -6.1 | 1.1e-09 | -0.22 | 0.76 | 0.05 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | ABCF3 | 0.13 | 0.08 | lasso | 4 | 0.11 | 1.6e-09 | -6.6 | -8.0 | 1.1e-15 | -0.33 | 0.96 | 0.03 | FALSE |
| 8 | METSIM | Adipose | DVL3 | 0.05 | 0.05 | lasso | 2 | 0.05 | 9.2e-08 | -5.2 | -5.2 | 1.5e-07 | -0.23 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | VWA5B2 | 0.15 | 0.00 | blup | 52 | 0.01 | 1.4e-01 | -3.8 | -5.3 | 9.2e-08 | -0.17 | 0.01 | 0.04 | FALSE |
| 10 | The Cancer Genome Atlas | Colon Adenocarcinoma | ABCF3 | 0.07 | 0.00 | blup | 51 | 0.01 | 4.4e-02 | -6.7 | -6.3 | 2.3e-10 | -0.25 | 0.01 | 0.88 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ECE2 | 0.04 | 0.02 | blup | 61 | 0.03 | 3.5e-04 | -7.4 | -6.6 | 4.4e-11 | -0.22 | 0.54 | 0.02 | FALSE |
| 12 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ABCF3 | 0.08 | 0.03 | blup | 51 | 0.06 | 6.1e-04 | -2.9 | -6.3 | 3.3e-10 | -0.22 | 0.02 | 0.69 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Adenocarcinoma | PSMD2 | 0.09 | 0.02 | blup | 50 | 0.05 | 1.2e-06 | 8.9 | -8.4 | 4.6e-17 | -0.78 | 0.00 | 0.99 | TRUE |
| 14 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CAMK2N2 | 0.04 | 0.01 | enet | 8 | 0.03 | 3.9e-04 | -2.7 | -5.8 | 7.7e-09 | -0.25 | 0.14 | 0.03 | FALSE |
| 15 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | VWA5B2 | 0.10 | 0.04 | blup | 51 | 0.04 | 1.8e-02 | -6.7 | 8.8 | 1.9e-18 | 0.37 | 0.03 | 0.33 | TRUE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | ABCF3 | 0.05 | 0.02 | lasso | 9 | 0.01 | 1.4e-02 | -3.4 | -5.4 | 7.9e-08 | -0.21 | 0.01 | 0.98 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | DVL3 | 0.02 | 0.01 | blup | 53 | 0.02 | 3.8e-03 | -2.9 | 5.2 | 2.2e-07 | 0.24 | 0.03 | 0.26 | FALSE |