[Hub]/) : Traits : Impedance of whole body :

chr4:24,422,187-27,132,182

Best TWAS P=2.8e-16 · Best GWAS P=5.92e-16 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ANAPC4 0.11 0.06 bslmm 562 0.09 6.4e-11 -7.5 -5.9 3.1e-09 0.82 0.01 0.99 FALSE
2 CommonMind Brain Pre-frontal Cortex SEPSECS 0.04 0.04 lasso 4 0.03 2.9e-04 -5.3 -5.4 7.5e-08 0.67 0.31 0.34 FALSE
3 CommonMind Brain Pre-frontal Cortex ZCCHC4 0.07 0.01 blup 568 0.02 3.1e-03 -7.7 -5.8 8.3e-09 0.67 0.13 0.76 FALSE
4 GTEx Adipose Subcutaneous ANAPC4 0.32 0.40 lasso 13 0.40 7.3e-35 -7.8 -7.8 6.4e-15 0.97 0.02 0.98 FALSE
5 GTEx Artery Aorta ANAPC4 0.40 0.43 lasso 5 0.42 5.4e-25 -7.8 -7.8 6.8e-15 0.97 0.03 0.97 FALSE
6 GTEx Artery Coronary ANAPC4 0.42 0.11 lasso 14 0.08 9.7e-04 -7.7 -6.1 1.1e-09 0.81 0.01 0.99 FALSE
7 GTEx Artery Tibial ANAPC4 0.37 0.42 enet 48 0.46 1.0e-39 -7.8 -7.9 2.3e-15 0.92 0.03 0.97 FALSE
8 GTEx Brain Caudate basal ganglia ANAPC4 0.35 0.10 lasso 8 0.04 2.2e-02 -2.7 -5.4 6.1e-08 0.72 0.13 0.76 FALSE
9 GTEx Brain Cerebellar Hemisphere ANAPC4 0.44 0.14 enet 33 0.27 1.7e-07 -7.6 -5.6 2.4e-08 0.75 0.07 0.87 FALSE
10 GTEx Brain Cerebellum PI4K2B 0.29 0.13 enet 5 0.11 4.3e-04 -6.0 -5.6 1.8e-08 0.76 0.06 0.89 FALSE
11 GTEx Brain Cortex ANAPC4 0.33 0.24 enet 23 0.26 7.5e-08 -7.5 -7.3 3.1e-13 0.87 0.02 0.98 FALSE
12 GTEx Brain Nucleus accumbens basal ganglia ANAPC4 0.41 0.15 enet 30 0.20 4.2e-06 -7.6 -6.9 6.5e-12 0.81 0.08 0.90 FALSE
13 GTEx Brain Putamen basal ganglia ANAPC4 0.25 0.03 lasso 7 0.04 3.6e-02 -7.6 -7.4 1.7e-13 0.89 0.06 0.54 FALSE
14 GTEx Breast Mammary Tissue ANAPC4 0.49 0.42 lasso 8 0.42 1.5e-23 -7.8 -8.2 2.8e-16 0.96 0.03 0.97 TRUE
15 GTEx Breast Mammary Tissue (Male) ANAPC4 0.49 0.30 enet 14 0.26 8.6e-07 -7.8 -6.8 8.8e-12 0.87 0.03 0.94 FALSE
16 GTEx Breast Mammary Tissue (Female) ANAPC4 0.30 0.28 lasso 8 0.19 2.2e-06 -7.8 -7.7 1.0e-14 0.97 0.02 0.97 FALSE
17 GTEx Cells EBV-transformed lymphocytes ZCCHC4 0.38 0.13 lasso 10 0.12 1.0e-04 -7.6 -6.6 3.3e-11 0.81 0.17 0.69 FALSE
18 GTEx Cells Transformed fibroblasts ANAPC4 0.14 0.20 lasso 8 0.19 2.3e-14 -7.8 -7.8 6.5e-15 0.97 0.01 0.99 FALSE
19 GTEx Cells Transformed fibroblasts ZCCHC4 0.13 0.03 enet 13 0.05 1.0e-04 -3.3 -6.0 1.5e-09 0.72 0.39 0.52 FALSE
20 GTEx Colon Sigmoid ANAPC4 0.28 0.27 enet 12 0.24 5.7e-09 -7.5 -7.7 1.4e-14 0.95 0.04 0.96 FALSE
21 GTEx Colon Transverse ANAPC4 0.36 0.38 lasso 8 0.41 5.5e-21 -7.8 -7.5 7.6e-14 0.96 0.03 0.97 FALSE
22 GTEx Esophagus Gastroesophageal Junction ANAPC4 0.26 0.22 enet 21 0.20 8.3e-08 -7.8 -7.5 4.6e-14 0.93 0.02 0.98 FALSE
23 GTEx Esophagus Mucosa ANAPC4 0.33 0.23 lasso 10 0.21 4.6e-14 -7.8 -7.8 7.3e-15 0.97 0.02 0.98 FALSE
24 GTEx Esophagus Muscularis PI4K2B 0.14 0.05 lasso 7 0.05 4.2e-04 -4.7 -5.8 7.6e-09 0.66 0.45 0.49 FALSE
25 GTEx Esophagus Muscularis ANAPC4 0.37 0.40 lasso 8 0.39 2.4e-25 -7.8 -7.8 6.5e-15 0.96 0.02 0.98 FALSE
26 GTEx Heart Atrial Appendage ANAPC4 0.18 0.12 lasso 9 0.10 3.4e-05 -7.8 -7.7 1.4e-14 0.97 0.01 0.99 FALSE
27 GTEx Heart Left Ventricle ANAPC4 0.13 0.10 lasso 7 0.07 1.6e-04 -7.9 -7.9 2.8e-15 0.98 0.01 0.98 FALSE
28 GTEx Liver ANAPC4 0.25 0.14 enet 16 0.02 1.1e-01 -7.8 -6.6 3.2e-11 0.78 0.02 0.90 FALSE
29 GTEx Lung ANAPC4 0.14 0.14 enet 11 0.13 4.4e-10 -7.5 -7.7 1.0e-14 0.95 0.04 0.96 FALSE
30 GTEx Muscle Skeletal ANAPC4 0.24 0.24 lasso 6 0.32 1.3e-32 -7.8 -6.5 7.4e-11 0.89 0.03 0.97 FALSE
31 GTEx Muscle Skeletal ZCCHC4 0.13 0.11 lasso 4 0.11 2.7e-11 -7.2 -7.1 8.8e-13 0.85 0.19 0.81 FALSE
32 GTEx Nerve Tibial ANAPC4 0.35 0.43 enet 14 0.43 4.3e-33 -7.8 -7.7 1.1e-14 0.96 0.03 0.97 FALSE
33 GTEx Pancreas ANAPC4 0.35 0.21 lasso 13 0.19 1.8e-08 -7.5 -7.6 2.3e-14 0.90 0.03 0.97 FALSE
34 GTEx Pituitary ANAPC4 0.38 0.12 lasso 7 0.07 8.8e-03 -7.9 -7.9 2.5e-15 0.94 0.02 0.93 FALSE
35 GTEx Prostate ANAPC4 0.28 0.12 enet 11 0.12 5.2e-04 -7.8 -6.3 3.9e-10 0.86 0.02 0.95 FALSE
36 GTEx Skin Not Sun Exposed Suprapubic ANAPC4 0.40 0.45 enet 28 0.44 1.5e-26 -7.8 -7.3 3.8e-13 0.94 0.03 0.97 FALSE
37 GTEx Skin Sun Exposed Lower leg ANAPC4 0.27 0.34 enet 23 0.34 4.4e-29 -7.8 -7.7 1.1e-14 0.95 0.03 0.97 FALSE
38 GTEx Spleen ANAPC4 0.41 0.28 enet 14 0.36 3.2e-10 -6.1 -7.4 1.4e-13 0.94 0.01 0.99 FALSE
39 GTEx Stomach ANAPC4 0.28 0.34 lasso 5 0.32 5.1e-16 -7.8 -7.8 4.6e-15 0.97 0.02 0.98 FALSE
40 GTEx Testis ANAPC4 0.12 0.10 lasso 5 0.08 2.3e-04 -7.8 -7.7 1.1e-14 0.97 0.02 0.96 FALSE
41 GTEx Thyroid ANAPC4 0.27 0.23 lasso 14 0.26 8.0e-20 -7.8 -7.5 5.1e-14 0.93 0.03 0.97 FALSE
42 METSIM Adipose ANAPC4 0.19 0.28 bslmm 552 0.28 3.5e-42 -7.8 -7.0 2.3e-12 0.94 0.02 0.98 FALSE
43 ROSMAP Brain Pre-frontal Cortex ANAPC4 0.19 0.27 lasso 11 0.27 3.5e-35 -7.8 -7.6 2.3e-14 0.96 0.02 0.98 FALSE
44 ROSMAP Brain Pre-frontal Cortex RBPJ 0.10 0.02 bslmm 469 0.05 5.3e-07 3.9 6.7 2.5e-11 0.03 0.08 0.90 TRUE
45 ROSMAP Brain Pre-frontal Cortex ZCCHC4 0.04 0.01 blup 560 0.01 1.8e-02 -4.7 -5.9 3.1e-09 0.75 0.10 0.51 FALSE
46 YFS Blood ANAPC4 0.22 0.28 bslmm 530 0.32 4.5e-109 -7.8 -7.1 1.1e-12 0.91 0.03 0.97 FALSE
47 The Cancer Genome Atlas Breast Invasive Carcinoma ZCCHC4 0.02 0.01 blup 83 0.00 4.5e-02 -7.2 -7.0 3.0e-12 0.88 0.10 0.84 FALSE
48 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ANAPC4 0.03 0.05 enet 10 0.04 1.9e-05 -7.8 -7.4 1.8e-13 0.90 0.02 0.98 FALSE
49 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ANAPC4 0.14 0.12 enet 11 0.09 4.5e-06 -7.8 -6.6 5.3e-11 0.83 0.02 0.97 FALSE
50 The Cancer Genome Atlas Brain Lower Grade Glioma ANAPC4 0.07 0.01 blup 69 0.03 2.9e-04 -7.8 -5.7 1.3e-08 0.76 0.01 0.98 FALSE
51 The Cancer Genome Atlas Lung Adenocarcinoma ZCCHC4 0.07 0.02 blup 83 0.05 2.6e-06 -3.7 -5.6 2.0e-08 0.74 0.09 0.88 FALSE
52 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ANAPC4 0.05 0.00 blup 69 0.01 7.5e-03 -7.0 -7.1 1.3e-12 0.85 0.01 0.94 FALSE
53 The Cancer Genome Atlas Pancreatic Adenocarcinoma ANAPC4 0.10 0.04 lasso 5 0.06 1.1e-03 -7.0 -7.4 1.1e-13 0.93 0.03 0.64 FALSE
54 The Cancer Genome Atlas Prostate Adenocarcinoma ANAPC4 0.08 0.04 blup 69 0.05 1.3e-05 -7.5 -5.4 7.0e-08 0.75 0.06 0.83 FALSE
55 The Cancer Genome Atlas Prostate Adenocarcinoma ZCCHC4 0.08 0.06 enet 13 0.08 3.4e-09 -7.2 -6.3 3.1e-10 0.81 0.23 0.77 FALSE
56 The Cancer Genome Atlas Thyroid Carcinoma ANAPC4 0.06 0.02 lasso 3 0.03 1.1e-03 -3.3 -5.3 1.5e-07 0.68 0.12 0.24 FALSE
57 The Cancer Genome Atlas Thyroid Carcinoma ZCCHC4 0.07 0.06 enet 12 0.09 1.7e-09 -7.6 -6.7 1.8e-11 0.84 0.13 0.87 FALSE