[Hub]/) : Traits : Impedance of whole body : ← →

chr4:24,422,187-27,132,182

Best TWAS P=2.8e-16 · Best GWAS P=5.92e-16 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	GTEx	Breast Mammary Tissue	ANAPC4	0.49	0.42	lasso	8	0.42	1.5e-23	-7.8	-8.2	2.8e-16	0.96	0.03	0.97	TRUE
44	ROSMAP	Brain Pre-frontal Cortex	RBPJ	0.10	0.02	bslmm	469	0.05	5.3e-07	3.9	6.7	2.5e-11	0.03	0.08	0.90	TRUE
7	GTEx	Artery Tibial	ANAPC4	0.37	0.42	enet	48	0.46	1.0e-39	-7.8	-7.9	2.3e-15	0.92	0.03	0.97	FALSE
34	GTEx	Pituitary	ANAPC4	0.38	0.12	lasso	7	0.07	8.8e-03	-7.9	-7.9	2.5e-15	0.94	0.02	0.93	FALSE
27	GTEx	Heart Left Ventricle	ANAPC4	0.13	0.10	lasso	7	0.07	1.6e-04	-7.9	-7.9	2.8e-15	0.98	0.01	0.98	FALSE
39	GTEx	Stomach	ANAPC4	0.28	0.34	lasso	5	0.32	5.1e-16	-7.8	-7.8	4.6e-15	0.97	0.02	0.98	FALSE
4	GTEx	Adipose Subcutaneous	ANAPC4	0.32	0.40	lasso	13	0.40	7.3e-35	-7.8	-7.8	6.4e-15	0.97	0.02	0.98	FALSE
18	GTEx	Cells Transformed fibroblasts	ANAPC4	0.14	0.20	lasso	8	0.19	2.3e-14	-7.8	-7.8	6.5e-15	0.97	0.01	0.99	FALSE
25	GTEx	Esophagus Muscularis	ANAPC4	0.37	0.40	lasso	8	0.39	2.4e-25	-7.8	-7.8	6.5e-15	0.96	0.02	0.98	FALSE
5	GTEx	Artery Aorta	ANAPC4	0.40	0.43	lasso	5	0.42	5.4e-25	-7.8	-7.8	6.8e-15	0.97	0.03	0.97	FALSE
23	GTEx	Esophagus Mucosa	ANAPC4	0.33	0.23	lasso	10	0.21	4.6e-14	-7.8	-7.8	7.3e-15	0.97	0.02	0.98	FALSE
16	GTEx	Breast Mammary Tissue (Female)	ANAPC4	0.30	0.28	lasso	8	0.19	2.2e-06	-7.8	-7.7	1.0e-14	0.97	0.02	0.97	FALSE
29	GTEx	Lung	ANAPC4	0.14	0.14	enet	11	0.13	4.4e-10	-7.5	-7.7	1.0e-14	0.95	0.04	0.96	FALSE
32	GTEx	Nerve Tibial	ANAPC4	0.35	0.43	enet	14	0.43	4.3e-33	-7.8	-7.7	1.1e-14	0.96	0.03	0.97	FALSE
37	GTEx	Skin Sun Exposed Lower leg	ANAPC4	0.27	0.34	enet	23	0.34	4.4e-29	-7.8	-7.7	1.1e-14	0.95	0.03	0.97	FALSE
40	GTEx	Testis	ANAPC4	0.12	0.10	lasso	5	0.08	2.3e-04	-7.8	-7.7	1.1e-14	0.97	0.02	0.96	FALSE
20	GTEx	Colon Sigmoid	ANAPC4	0.28	0.27	enet	12	0.24	5.7e-09	-7.5	-7.7	1.4e-14	0.95	0.04	0.96	FALSE
26	GTEx	Heart Atrial Appendage	ANAPC4	0.18	0.12	lasso	9	0.10	3.4e-05	-7.8	-7.7	1.4e-14	0.97	0.01	0.99	FALSE
33	GTEx	Pancreas	ANAPC4	0.35	0.21	lasso	13	0.19	1.8e-08	-7.5	-7.6	2.3e-14	0.90	0.03	0.97	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	ANAPC4	0.19	0.27	lasso	11	0.27	3.5e-35	-7.8	-7.6	2.3e-14	0.96	0.02	0.98	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	ANAPC4	0.26	0.22	enet	21	0.20	8.3e-08	-7.8	-7.5	4.6e-14	0.93	0.02	0.98	FALSE
41	GTEx	Thyroid	ANAPC4	0.27	0.23	lasso	14	0.26	8.0e-20	-7.8	-7.5	5.1e-14	0.93	0.03	0.97	FALSE
21	GTEx	Colon Transverse	ANAPC4	0.36	0.38	lasso	8	0.41	5.5e-21	-7.8	-7.5	7.6e-14	0.96	0.03	0.97	FALSE
53	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ANAPC4	0.10	0.04	lasso	5	0.06	1.1e-03	-7.0	-7.4	1.1e-13	0.93	0.03	0.64	FALSE
38	GTEx	Spleen	ANAPC4	0.41	0.28	enet	14	0.36	3.2e-10	-6.1	-7.4	1.4e-13	0.94	0.01	0.99	FALSE
13	GTEx	Brain Putamen basal ganglia	ANAPC4	0.25	0.03	lasso	7	0.04	3.6e-02	-7.6	-7.4	1.7e-13	0.89	0.06	0.54	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ANAPC4	0.03	0.05	enet	10	0.04	1.9e-05	-7.8	-7.4	1.8e-13	0.90	0.02	0.98	FALSE
11	GTEx	Brain Cortex	ANAPC4	0.33	0.24	enet	23	0.26	7.5e-08	-7.5	-7.3	3.1e-13	0.87	0.02	0.98	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	ANAPC4	0.40	0.45	enet	28	0.44	1.5e-26	-7.8	-7.3	3.8e-13	0.94	0.03	0.97	FALSE
31	GTEx	Muscle Skeletal	ZCCHC4	0.13	0.11	lasso	4	0.11	2.7e-11	-7.2	-7.1	8.8e-13	0.85	0.19	0.81	FALSE
46	YFS	Blood	ANAPC4	0.22	0.28	bslmm	530	0.32	4.5e-109	-7.8	-7.1	1.1e-12	0.91	0.03	0.97	FALSE
52	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ANAPC4	0.05	0.00	blup	69	0.01	7.5e-03	-7.0	-7.1	1.3e-12	0.85	0.01	0.94	FALSE
42	METSIM	Adipose	ANAPC4	0.19	0.28	bslmm	552	0.28	3.5e-42	-7.8	-7.0	2.3e-12	0.94	0.02	0.98	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZCCHC4	0.02	0.01	blup	83	0.00	4.5e-02	-7.2	-7.0	3.0e-12	0.88	0.10	0.84	FALSE
12	GTEx	Brain Nucleus accumbens basal ganglia	ANAPC4	0.41	0.15	enet	30	0.20	4.2e-06	-7.6	-6.9	6.5e-12	0.81	0.08	0.90	FALSE
15	GTEx	Breast Mammary Tissue (Male)	ANAPC4	0.49	0.30	enet	14	0.26	8.6e-07	-7.8	-6.8	8.8e-12	0.87	0.03	0.94	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	ZCCHC4	0.07	0.06	enet	12	0.09	1.7e-09	-7.6	-6.7	1.8e-11	0.84	0.13	0.87	FALSE
28	GTEx	Liver	ANAPC4	0.25	0.14	enet	16	0.02	1.1e-01	-7.8	-6.6	3.2e-11	0.78	0.02	0.90	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	ZCCHC4	0.38	0.13	lasso	10	0.12	1.0e-04	-7.6	-6.6	3.3e-11	0.81	0.17	0.69	FALSE
49	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ANAPC4	0.14	0.12	enet	11	0.09	4.5e-06	-7.8	-6.6	5.3e-11	0.83	0.02	0.97	FALSE
30	GTEx	Muscle Skeletal	ANAPC4	0.24	0.24	lasso	6	0.32	1.3e-32	-7.8	-6.5	7.4e-11	0.89	0.03	0.97	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZCCHC4	0.08	0.06	enet	13	0.08	3.4e-09	-7.2	-6.3	3.1e-10	0.81	0.23	0.77	FALSE
35	GTEx	Prostate	ANAPC4	0.28	0.12	enet	11	0.12	5.2e-04	-7.8	-6.3	3.9e-10	0.86	0.02	0.95	FALSE
6	GTEx	Artery Coronary	ANAPC4	0.42	0.11	lasso	14	0.08	9.7e-04	-7.7	-6.1	1.1e-09	0.81	0.01	0.99	FALSE
19	GTEx	Cells Transformed fibroblasts	ZCCHC4	0.13	0.03	enet	13	0.05	1.0e-04	-3.3	-6.0	1.5e-09	0.72	0.39	0.52	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ANAPC4	0.11	0.06	bslmm	562	0.09	6.4e-11	-7.5	-5.9	3.1e-09	0.82	0.01	0.99	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	ZCCHC4	0.04	0.01	blup	560	0.01	1.8e-02	-4.7	-5.9	3.1e-09	0.75	0.10	0.51	FALSE
24	GTEx	Esophagus Muscularis	PI4K2B	0.14	0.05	lasso	7	0.05	4.2e-04	-4.7	-5.8	7.6e-09	0.66	0.45	0.49	FALSE
3	CommonMind	Brain Pre-frontal Cortex	ZCCHC4	0.07	0.01	blup	568	0.02	3.1e-03	-7.7	-5.8	8.3e-09	0.67	0.13	0.76	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	ANAPC4	0.07	0.01	blup	69	0.03	2.9e-04	-7.8	-5.7	1.3e-08	0.76	0.01	0.98	FALSE
10	GTEx	Brain Cerebellum	PI4K2B	0.29	0.13	enet	5	0.11	4.3e-04	-6.0	-5.6	1.8e-08	0.76	0.06	0.89	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	ZCCHC4	0.07	0.02	blup	83	0.05	2.6e-06	-3.7	-5.6	2.0e-08	0.74	0.09	0.88	FALSE
9	GTEx	Brain Cerebellar Hemisphere	ANAPC4	0.44	0.14	enet	33	0.27	1.7e-07	-7.6	-5.6	2.4e-08	0.75	0.07	0.87	FALSE
8	GTEx	Brain Caudate basal ganglia	ANAPC4	0.35	0.10	lasso	8	0.04	2.2e-02	-2.7	-5.4	6.1e-08	0.72	0.13	0.76	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	ANAPC4	0.08	0.04	blup	69	0.05	1.3e-05	-7.5	-5.4	7.0e-08	0.75	0.06	0.83	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SEPSECS	0.04	0.04	lasso	4	0.03	2.9e-04	-5.3	-5.4	7.5e-08	0.67	0.31	0.34	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	ANAPC4	0.06	0.02	lasso	3	0.03	1.1e-03	-3.3	-5.3	1.5e-07	0.68	0.12	0.24	FALSE