Best TWAS P=1.44e-12 · Best GWAS P=3.41e-10 conditioned to 0.0453
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | POLR2B | 0.09 | 0.05 | bslmm | 572 | 0.02 | 4.7e-04 | -6.3 | -7.1 | 1.4e-12 | 0.77 | 0.00 | 1.00 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | CLOCK | 0.19 | 0.09 | lasso | 6 | 0.11 | 2.0e-08 | -3.7 | 5.5 | 4.1e-08 | 0.08 | 0.27 | 0.68 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | C4orf14 | 0.07 | 0.05 | blup | 57 | 0.06 | 3.2e-06 | -2.9 | 5.4 | 5.9e-08 | -0.80 | 0.18 | 0.78 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | REST | 0.04 | 0.02 | bslmm | 536 | 0.02 | 3.4e-03 | 4.9 | 5.4 | 6.1e-08 | -0.28 | 0.08 | 0.80 | FALSE |
| 6 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CLOCK | 0.08 | 0.07 | enet | 9 | 0.06 | 4.5e-05 | 5.2 | 5.3 | 1.5e-07 | 0.05 | 0.02 | 0.97 | FALSE |
| 2 | GTEx | Artery Tibial | TMEM165 | 0.07 | 0.02 | lasso | 5 | 0.01 | 3.2e-02 | -4.3 | -5.2 | 2.4e-07 | -0.09 | 0.03 | 0.91 | FALSE |
| 4 | GTEx | Lung | CLOCK | 0.07 | 0.02 | lasso | 4 | 0.03 | 3.0e-03 | -3.6 | 5.1 | 2.7e-07 | 0.09 | 0.03 | 0.92 | FALSE |