Best TWAS P=2.18e-10 · Best GWAS P=1.16e-10 conditioned to 0.00502
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ZNF292 | 0.04 | 0.05 | lasso | 12 | 0.03 | 4.1e-05 | 5.6 | -5.8 | 8.6e-09 | 0.59 | 0.38 | 0.62 | FALSE |
2 | GTEx | Artery Aorta | RP11-393I2.4 | 0.10 | 0.03 | lasso | 5 | 0.02 | 2.4e-02 | 4.7 | -5.4 | 7.5e-08 | 0.62 | 0.13 | 0.77 | FALSE |
3 | GTEx | Cells EBV-transformed lymphocytes | C6orf163 | 0.18 | 0.14 | lasso | 4 | 0.15 | 1.5e-05 | 5.5 | 5.4 | 7.1e-08 | -0.58 | 0.50 | 0.28 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | SMIM8 | 0.18 | 0.14 | lasso | 5 | 0.12 | 1.4e-09 | 5.5 | -5.4 | 5.6e-08 | 0.59 | 0.76 | 0.24 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | C6orf163 | 0.16 | 0.14 | lasso | 3 | 0.18 | 2.7e-13 | 5.4 | 5.6 | 2.7e-08 | -0.55 | 0.84 | 0.16 | FALSE |
6 | GTEx | Nerve Tibial | ZNF292 | 0.09 | 0.07 | enet | 16 | 0.10 | 1.5e-07 | -5.9 | -5.8 | 5.2e-09 | 0.71 | 0.39 | 0.61 | FALSE |
7 | GTEx | Nerve Tibial | RP11-393I2.4 | 0.08 | 0.09 | enet | 18 | 0.09 | 6.8e-07 | 4.6 | -5.7 | 1.6e-08 | 0.65 | 0.37 | 0.63 | FALSE |
8 | GTEx | Stomach | C6orf163 | 0.10 | 0.06 | lasso | 1 | 0.05 | 2.3e-03 | 5.4 | 5.4 | 7.9e-08 | -0.58 | 0.31 | 0.15 | FALSE |
9 | METSIM | Adipose | C6orf164 | 0.05 | 0.06 | lasso | 8 | 0.06 | 9.3e-10 | 5.4 | 5.3 | 1.0e-07 | -0.60 | 0.82 | 0.18 | FALSE |
10 | ROSMAP | Brain Pre-frontal Cortex | SMIM8 | 0.21 | 0.33 | enet | 34 | 0.38 | 3.9e-52 | -5.9 | 5.2 | 2.0e-07 | -0.61 | 0.10 | 0.90 | FALSE |
11 | ROSMAP | Brain Pre-frontal Cortex | SLC35A1 | 0.30 | 0.48 | enet | 25 | 0.50 | 5.7e-73 | -6.2 | -6.0 | 1.7e-09 | 0.95 | 0.03 | 0.97 | FALSE |
12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C6orf164 | 0.06 | 0.05 | blup | 94 | 0.06 | 1.0e-11 | -5.4 | 5.8 | 8.9e-09 | -0.57 | 0.03 | 0.97 | FALSE |
13 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | C6orf164 | 0.07 | 0.06 | blup | 95 | 0.05 | 2.0e-03 | -6.1 | 6.1 | 1.4e-09 | -0.72 | 0.02 | 0.96 | FALSE |
14 | The Cancer Genome Atlas | Colon Adenocarcinoma | C6orf164 | 0.05 | 0.02 | enet | 8 | 0.02 | 1.9e-02 | -5.9 | 5.8 | 8.2e-09 | -0.67 | 0.02 | 0.74 | FALSE |
15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C6orf164 | 0.06 | 0.08 | blup | 94 | 0.08 | 8.3e-09 | -5.9 | 6.1 | 1.0e-09 | -0.69 | 0.01 | 0.99 | FALSE |
16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC35A1 | 0.02 | 0.01 | blup | 72 | 0.00 | 8.7e-02 | -6.0 | 6.0 | 2.6e-09 | -0.83 | 0.01 | 0.91 | FALSE |
17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C6orf164 | 0.11 | 0.12 | blup | 95 | 0.14 | 5.0e-15 | -5.9 | 5.5 | 2.9e-08 | -0.64 | 0.01 | 0.99 | FALSE |
18 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C6orf164 | 0.11 | 0.14 | enet | 8 | 0.12 | 1.6e-07 | -5.9 | 6.1 | 9.2e-10 | -0.68 | 0.01 | 0.99 | FALSE |
19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C6orf164 | 0.04 | 0.02 | blup | 95 | 0.04 | 5.4e-05 | 5.4 | 6.3 | 2.2e-10 | -0.70 | 0.03 | 0.97 | TRUE |
20 | The Cancer Genome Atlas | Lung Adenocarcinoma | C6orf164 | 0.09 | 0.12 | blup | 95 | 0.11 | 4.1e-13 | -5.9 | 5.8 | 8.0e-09 | -0.71 | 0.01 | 0.99 | FALSE |
21 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C6orf164 | 0.06 | 0.06 | lasso | 4 | 0.07 | 4.6e-08 | -6.1 | 5.9 | 3.4e-09 | -0.67 | 0.01 | 0.99 | FALSE |
22 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C6orf163 | 0.06 | 0.02 | blup | 66 | 0.02 | 1.1e-02 | 5.4 | 5.9 | 4.0e-09 | -0.65 | 0.06 | 0.66 | FALSE |
23 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C6orf164 | 0.12 | 0.12 | blup | 95 | 0.14 | 7.4e-10 | -5.5 | 5.9 | 3.2e-09 | -0.72 | 0.02 | 0.98 | FALSE |
24 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SLC35A1 | 0.04 | 0.03 | lasso | 5 | 0.02 | 1.3e-02 | -6.2 | 6.2 | 7.6e-10 | -0.94 | 0.01 | 0.90 | FALSE |
25 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C6orf164 | 0.07 | 0.11 | enet | 8 | 0.10 | 8.4e-05 | -6.0 | 5.8 | 5.8e-09 | -0.67 | 0.02 | 0.97 | FALSE |
26 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C6orf164 | 0.17 | 0.13 | lasso | 4 | 0.10 | 6.2e-08 | -6.0 | 5.9 | 4.7e-09 | -0.66 | 0.01 | 0.99 | FALSE |
27 | The Cancer Genome Atlas | Thyroid Carcinoma | C6orf164 | 0.18 | 0.24 | lasso | 4 | 0.25 | 1.4e-24 | -5.9 | 6.0 | 2.1e-09 | -0.68 | 0.01 | 0.99 | FALSE |
28 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC35A1 | 0.08 | 0.07 | enet | 17 | 0.07 | 5.0e-07 | -6.0 | -5.9 | 4.2e-09 | 0.90 | 0.01 | 0.99 | FALSE |