TWAS hub - ZNF292

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0450	0.0210	3.3e-05	0.047	0.034	0.024	0.033	0.035	1.8e-06	4.7e-05	5.1e-04	5.7e-05	4.0e-05
2	GTEx	Nerve Tibial	0.0878	0.0306	9.9e-08	0.066	NA	0.100	NA	0.074	2.0e-05	NA	1.5e-07	NA	6.3e-06
3	TCGA	Brain Lower Grade Glioma	0.0297	0.0208	1.8e-03	0.017	0.022	0.020	NA	0.025	4.0e-03	1.4e-03	2.0e-03	NA	7.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood White Count	10.5	77.9	91.4	9.3	9.6	7.5
Relative age voice broke	10.5	16.1	21.8	-4.7	-3.9	-3.4
Medication: Aspirin	7.3	9.5	9.9	3.1	3.0	3.1
Impedance of leg (left)	6.7	32.5	39.9	-6.2	-6.3	-4.4
Allergy or Eczema	6.6	17.4	19.7	-4.1	-4.4	-4.0
Impedance of leg (right)	6.4	31.0	38.6	-5.9	-6.2	-4.5
Guilty feelings	6.3	9.5	14.0	3.7	3.1	2.2
Angina	5.8	7.6	9.1	3.0	2.6	2.7
Angina (self-reported)	5.7	7.5	8.4	2.9	2.5	2.8
Heart attack/myocardial infarction (self-reported)	5.7	7.4	7.9	2.7	2.8	2.6
Medication: Aspirin	5.5	7.3	8.5	2.6	2.6	2.9
Risk taking	5.4	7.9	9.8	3.1	3.0	2.2
Impedance of whole body	5.4	27.5	34.1	-5.8	-5.8	-3.9
Blood Eosinophil Count	5.3	41.1	45.6	-6.3	-6.7	-6.2
Heart attack	5.3	6.8	7.9	2.5	2.8	2.5
Impedance of arm (right)	5.3	24.8	32.2	-5.2	-5.7	-3.9
Falls in the last year	5.3	7.2	9.2	2.8	2.1	3.0
Allergy	5.1	11.8	14.6	3.2	3.8	3.2
Birth weight	5.0	10.8	14.6	3.8	3.0	2.9
Hayfever, allergic rhinitis or eczema	4.9	10.5	12.9	-3.1	-3.6	-3.1
Ever taken oral contraceptive pill	4.9	5.5	6.5	2.6	2.5	1.9
Hayfever/allergic rhinitis (self-reported)	4.8	6.3	7.2	-2.6	-2.7	-2.2
Asthma (self-reported)	4.8	9.6	10.3	-2.9	-3.2	-3.2
Shortness of breath walking on level ground	4.5	5.3	6.9	1.9	2.6	2.4
Hypothyroidism (self reported)	4.3	9.9	10.2	-3.2	-3.2	-3.1
Medication: Ramipril	4.1	5.3	5.9	2.4	2.4	2.1
Asthma	3.9	7.6	8.5	-2.6	-2.9	-2.8
Reason for reducing amount of alcohol drunk: Health precaution	3.9	4.6	6.7	-2.0	-1.8	-2.6
Alcohol intake versus 10 years previously	3.8	5.6	7.0	-2.4	-2.0	-2.6
Illnesses of father: High blood pressure	3.6	4.5	6.6	2.6	2.3	1.2
Primary Biliary Cirrhosis	3.5	5.0	6.6	2.1	2.0	2.6
Fluid intelligence score	3.5	7.2	7.4	-2.7	-2.7	-2.7
Knee pain experienced in last month	3.5	5.5	7.0	2.3	2.6	2.0
Mouth/teeth dental problems: Mouth ulcers	3.5	5.6	8.2	1.9	2.2	2.9
Impedance of arm (left)	3.4	15.7	20.1	-4.2	-4.5	-3.0
Medication: Blood pressure	3.4	6.0	7.4	2.7	2.4	2.1
Medication: Seretide 50 evohaler	3.4	3.9	4.6	-1.8	-2.0	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	3.4	3.7	6.0	1.8	2.5	1.3
Age at First Birth	3.1	4.6	5.5	-2.3	-2.3	-1.7
Body Mass Index (BMI) (2010)	3.1	4.2	4.7	2.0	2.2	2.0
Respiratory disease	3.1	6.9	8.4	-2.3	-2.7	-2.9
Age when periods started (menarche)	3.1	7.5	9.4	-3.1	-2.9	-2.1
Migraine (self-reported)	3.1	3.9	6.4	-2.5	-1.9	-1.4
Vascular/heart problems diagnosed by doctor	3.0	8.3	10.1	-3.2	-2.7	-2.8
Relative age of first facial hair	2.9	5.9	7.0	-2.6	-2.1	-2.5
Lung FVC	2.7	13.9	15.7	3.7	4.0	3.5
Number of full sisters	2.7	3.2	4.7	1.2	1.9	2.2
High blood pressure (siblings)	2.5	3.7	5.6	1.7	2.4	1.6
Health satisfaction	2.5	3.3	4.3	-1.6	-1.7	-2.1
Leg fat-free mass (right)	2.5	13.6	17.6	4.2	4.0	2.7
Leg predicted mass (right)	2.5	13.6	17.6	4.2	4.0	2.7
Fractured/broken bones in last 5 years	2.5	3.2	3.9	-1.9	-2.0	-1.4
Rheumatoid Arthritis	2.4	3.3	5.4	1.6	1.4	2.3
Supplements: Vitamin C	2.4	2.8	3.4	1.9	1.7	1.5
Average weekly beer plus cider intake	2.4	3.5	3.7	1.9	1.9	1.8
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	3.0	1.7	1.6	1.3
Leg fat-free mass (left)	2.3	12.0	16.0	4.0	3.7	2.5
Emphysema/chronic bronchitis	2.3	2.6	2.9	1.7	1.5	1.6
Ever had bowel cancer screening	2.3	2.7	5.7	2.4	1.1	1.0
Depression (Nagel 2018)	2.2	3.3	3.7	1.8	1.9	1.8
Coronary Artery Disease (CAD)	2.2	2.6	2.9	-1.5	-1.6	-1.7
Vitamin and mineral supplements	2.2	2.9	4.1	-2.0	-1.5	-1.6
Leg predicted mass (left)	2.2	11.9	16.0	4.0	3.7	2.4
Wheeze or whistling in the chest in last year	2.2	3.9	6.3	-1.4	-1.9	-2.5
Medication for pain relief, constipation, heartburn	2.2	3.8	5.9	-1.5	-1.8	-2.4
Ever had hysterectomy (womb removed)	2.1	2.3	4.1	1.1	1.4	2.0
Multivitamins +/- minerals	2.1	2.6	3.9	2.0	1.5	1.3
High blood pressure	2.0	5.5	7.1	2.7	2.1	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.4	6.6	2.5	2.6	2.6
Hypothyroidism/myxoedema (self-reported)	2.0	3.9	4.3	-2.1	-2.1	-1.8
Whole body fat-free mass	2.0	11.4	16.0	4.0	3.5	2.4
Whole body water mass	2.0	11.3	16.0	4.0	3.5	2.3
Crohns Disease (2012)	1.9	3.0	3.5	-1.8	-1.9	-1.5
Mean Putamen Volume	1.9	2.1	2.9	-1.7	-1.2	-1.4
High blood pressure (mother)	1.9	2.6	2.8	1.6	1.6	1.7
Alcohol intake frequency.	1.9	4.4	6.2	-2.5	-2.4	-1.1
Hypertension (Self-reported)	1.9	5.4	7.0	2.6	2.1	2.2
Mineral and other dietary supplements	1.9	2.6	2.7	-1.6	-1.6	-1.6
Alzheimer’s Disease (including proxy)	1.8	2.6	3.0	-1.5	-1.7	-1.6
Hand grip strength (left)	1.8	4.7	6.2	2.4	2.5	1.4
Average weekly fortified wine intake	1.8	2.1	2.7	1.6	1.5	1.1
Medication: Simvastatin	1.8	2.6	3.5	1.2	1.6	1.9
Trunk fat-free mass	1.8	10.2	15.1	3.9	3.3	2.2
Medication: Lansoprazole	1.8	2.1	2.5	1.6	1.3	1.4
Trunk predicted mass	1.8	10.1	14.9	3.9	3.3	2.2
Arm fat-free mass (right)	1.8	9.3	12.8	3.6	3.2	2.2
Number of children fathered	1.8	2.1	2.7	1.1	1.6	1.6
Arm predicted mass (right)	1.8	9.3	12.5	3.5	3.2	2.2
Handedness (chirality/laterality): Left-handed	1.8	2.1	3.5	-1.2	-1.2	-1.9
HDL Cholesterol	1.7	2.8	3.2	-1.7	-1.8	-1.6
Fed-up feelings	1.7	3.1	3.9	2.0	1.8	1.5
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	3.9	1.1	1.0	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.1	3.1	-1.5	-1.8	-0.9
Hearing aid user	1.7	2.0	3.2	1.8	1.4	0.9
Basal metabolic rate	1.7	9.2	12.8	3.6	3.2	2.1
Loud music exposure frequency	1.6	1.8	3.5	0.6	1.2	1.9
Forced vital capacity (FVC), Best measure	1.5	5.5	6.2	2.4	2.1	2.5
Diastolic blood pressure, automated reading	1.5	4.6	6.3	2.3	2.5	1.5
Lupus	1.4	2.1	2.9	1.2	1.4	1.7
Neuroticism	1.4	3.5	4.8	2.2	2.0	1.1
Diabetes (self-reported)	1.4	2.2	3.2	1.3	1.3	1.8
Headache pain in last month	1.4	2.4	2.5	-1.5	-1.6	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	4.0	2.0	1.8	1.2
Supplements: Fish oil (including cod liver oil)	1.4	1.8	2.5	1.6	1.4	1.0
Major Depression (MDD)	1.3	1.6	2.3	1.5	1.3	0.9
Medication: Levothyroxine sodium	1.3	2.2	2.5	-1.6	-1.3	-1.6
Neck or shoulder pain in last month	1.3	1.8	2.8	-0.7	-1.5	-1.7
Miserableness	1.3	2.2	3.3	1.5	1.8	1.1
Eye problems/disorders: Glaucoma	1.3	1.5	2.9	-1.7	-1.0	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.6	3.3	-1.7	-1.8	-1.3
Number of incorrect matches in round	1.2	2.1	3.2	1.8	0.8	1.5
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	2.6	1.6	1.5	1.0
Mouth/teeth dental problems	1.2	1.9	2.5	-1.3	-1.2	-1.6
Happiness	1.2	1.5	3.8	-0.5	-0.6	-2.0
Heart disease (mother)	1.2	1.4	2.0	1.1	1.0	1.4
Mood swings	1.2	2.2	3.3	1.5	1.8	0.9
Medication: Blood pressure	1.2	2.3	3.7	1.0	1.5	1.9
Arm fat-free mass (left)	1.2	6.3	9.4	3.1	2.5	1.7
Serious illness, injury or assault to yourself	1.1	1.4	1.5	1.1	1.2	1.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	2.4	-1.5	-1.2	-1.3
Comparative height size at age 10	1.1	5.9	12.0	3.5	1.6	1.8
Family relationship satisfaction	1.1	1.4	1.7	-1.3	-1.0	-1.2
Osteoarthritis (self-reported)	1.1	1.4	2.5	-1.0	-1.6	-0.9
Commuting to job workplace: Public transport	1.1	1.3	2.2	0.7	1.2	1.5
Neuroticism (2016)	1.0	1.4	2.0	1.2	1.4	0.8
Blood Red Count	1.0	9.5	12.6	-3.5	-3.1	-2.5
Hand grip strength (right)	1.0	2.7	3.5	1.7	1.9	1.3
Neuroticism score	1.0	2.1	2.9	1.5	1.7	1.0
Length of working week for main job	1.0	1.1	1.2	-1.1	-1.0	-1.1
Pulse wave reflection index	1.0	1.2	1.8	1.1	1.3	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.2	1.1	0.3	1.5
Arm predicted mass (left)	1.0	5.2	7.7	2.8	2.3	1.6
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	1.5	1.2	1.1	0.8
Trunk fat percentage	0.9	3.8	5.5	-2.4	-2.0	-1.3
Supplements: Glucosamine	0.9	1.2	1.5	1.2	0.9	1.2
Qualifications: None of the above	0.9	1.8	3.8	0.8	1.0	1.9
Medication: Paracetamol	0.9	1.5	2.6	0.8	1.2	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.8	1.7	0.8	0.4
Medication: Gliclazide	0.9	1.1	1.6	1.3	0.9	0.9
Intelligence (Savage-Jansen 2018)	0.8	2.4	4.2	-2.0	-1.4	-1.0
Alzheimer’s Disease (in mother)	0.8	0.9	1.2	-0.9	-0.8	-1.1
Heel T-Score	0.8	6.6	10.0	-2.6	-3.2	-1.8
Chronotype (morning person)	0.8	1.9	3.7	-1.9	-0.5	-1.3
Medication: Atenolol	0.8	0.9	1.4	0.5	1.1	1.2
Chronic bronchitis/emphysema (father)	0.8	1.0	1.2	-0.9	-1.1	-0.9
Illnesses of siblings	0.8	1.2	1.7	-1.0	-1.3	-0.9
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	3.3	1.8	1.6	1.4
Medication: Cholesterol lowering	0.8	1.3	1.9	0.9	1.1	1.4
Worry too long after embarrassment	0.8	1.3	1.5	1.2	1.0	1.2
Qualifications: College or University degree	0.8	2.6	5.0	2.2	1.5	0.7
Age at last live birth	0.8	1.2	2.0	1.4	1.0	0.8
Medication for cholesterol	0.8	1.3	2.2	-0.6	-1.1	-1.5
Verbal and Numeric Reasoning (VNR)	0.7	1.6	2.2	-1.5	-1.3	-1.0
Current tobacco smoking	0.7	1.1	1.6	1.3	1.2	0.6
Forced vital capacity (FVC)	0.7	2.8	3.7	1.9	1.4	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	1.8	1.1	1.3	0.5
Glaucoma (self-reported)	0.7	0.9	1.1	-1.1	-0.8	-0.9
Body fat percentage	0.7	2.9	4.8	-2.2	-1.7	-1.0
Had major operations	0.7	0.8	1.2	0.8	0.7	1.1
Medication: Paracetamol	0.7	1.1	2.0	0.7	0.9	1.4
Pain experienced in last month	0.7	1.1	2.1	0.3	1.1	1.4
LDL Cholesterol	0.6	0.9	1.3	1.1	1.1	0.6
Blood Platelet Count	0.6	6.8	8.9	-2.6	-2.2	-3.0
Waist Hip Ratio (WHR)	0.6	2.5	4.0	-1.2	-2.0	-1.4
Alcohol usually taken with meals	0.6	0.9	1.3	-0.9	-1.2	-0.7
Hearing difficulty/problems with background noise	0.6	1.0	1.8	-0.0	-1.1	-1.3
Pain all over the body in last month	0.6	0.6	1.2	-0.7	-1.1	-0.3
Mother’s age at death	0.6	0.7	1.6	0.5	0.5	1.2
Ever had prostate specific antigen (PSA) test	0.6	0.6	0.9	-0.6	-0.9	-0.8
Basal cell carcinoma (self-reported)	0.6	0.7	1.5	1.2	0.7	0.3
Schizophrenia (2018)	0.5	0.9	1.8	1.0	-1.4	-0.3
Ulcerative Colitis (UC)	0.5	1.0	2.3	0.7	0.4	1.5
Breast Cancer	0.5	1.3	3.6	-0.0	-0.6	-1.9
Bipolar Disorder (2011)	0.5	0.5	1.0	-0.3	-1.0	-0.6
Schizophrenia (2014)	0.5	1.2	2.5	0.9	-1.6	-0.5
BMI	0.5	2.8	4.4	1.6	2.1	1.2
Smoking Status	0.5	1.2	2.3	1.5	0.9	0.6
Sensitivity / hurt feelings	0.5	0.9	1.3	0.9	1.1	0.7
Frequency of depressed mood in last 2 weeks	0.5	0.8	0.9	0.8	1.0	0.8
Maternal smoking around birth	0.5	0.7	0.8	0.9	0.8	0.8
Nervous feelings	0.5	0.9	1.2	-0.9	-0.9	-1.1
Financial difficulties in last 2 years	0.5	0.7	1.3	-0.3	0.8	1.1
Arm fat percentage (right)	0.5	2.1	3.3	-1.8	-1.4	-1.0
Prospective memory result	0.5	0.6	1.3	0.3	0.5	1.1
Breastfed as a baby	0.5	0.6	1.1	0.6	1.0	0.6
Leg fat percentage (right)	0.5	1.7	3.2	-1.8	-1.1	-0.7
Medication: Ibuprofen	0.5	0.6	0.9	0.6	0.9	0.8
Leg pain on walking	0.5	0.6	1.7	1.3	0.4	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	0.9	0.9	0.6	0.6
Qualifications: nursing, teaching	0.5	0.8	1.5	-0.3	-1.0	-1.2
Smoking status: Current	0.5	0.8	1.4	1.2	0.9	0.2
Leg fat percentage (left)	0.5	1.7	3.6	-1.9	-1.1	-0.6
Irritability	0.5	0.8	1.7	0.6	1.3	0.6
Bipolar Disorder or Schizophrenia	0.4	0.9	1.4	1.2	-1.1	0.1
Depressed Affect (Nagel 2018)	0.4	0.8	1.0	1.0	1.0	0.6
Number of treatments/medications taken	0.4	0.7	1.5	0.6	0.5	1.2
Stomach or abdominal pain in last month	0.4	0.4	1.3	1.2	0.1	-0.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.1	0.6	0.4	1.0
Sitting height	0.4	3.1	6.4	2.5	1.5	0.9
Body mass index (BMI)	0.4	1.8	2.7	1.2	1.6	1.1
Weight	0.4	2.1	2.8	1.7	1.5	1.1
Worrier / anxious feelings	0.4	0.7	1.1	1.1	0.9	0.3
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.0	1.4	0.9	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.8	0.5	0.9	0.7
Depression (self-reported)	0.4	0.5	0.7	0.8	0.8	0.2
Illnesses of mother	0.4	0.5	1.4	-0.2	-0.4	-1.2
Blood clot in the leg (DVT)	0.4	0.6	0.8	-0.9	-0.9	-0.2
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.0	0.4	1.0	0.5
Age at first live birth	0.4	0.7	0.9	0.9	0.7	0.9
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.7	0.8	0.8	0.2
Illnesses of father: Heart disease	0.4	0.5	0.9	-0.9	-0.7	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.5	1.2	0.8	0.8
Friendships satisfaction	0.4	0.5	0.9	-0.4	-0.6	-1.0
Medication: Bendroflumethiazide	0.4	0.6	1.1	0.5	1.0	0.6
Number of operations (self-reported)	0.4	0.7	1.5	0.7	0.2	1.2
Alcohol drinker status: Previous	0.4	0.4	1.1	-0.3	-0.2	1.1
Neuroticism (Nagel 2018)	0.3	0.7	1.3	1.1	0.8	0.4
Irritable Bowel Disease (IBD)	0.3	0.6	1.9	0.1	0.0	1.4
Reaction Time	0.3	0.6	1.2	0.7	0.2	1.1
Ulcerative Colitis	0.3	0.4	1.0	-0.4	-1.0	0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.8	0.6	0.2	0.9
Severe depression (siblings)	0.3	0.4	0.8	0.6	0.9	-0.0
Pack years adult smoking proportion	0.3	0.4	1.0	0.4	1.0	-0.2
Hair/balding pattern: Pattern 2	0.3	0.4	0.5	0.7	0.6	0.7
Had other major operations	0.3	0.3	0.8	0.4	-0.2	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.1	-0.9	-1.0	-0.4
Mouth/teeth dental problems: Dentures	0.3	0.5	1.1	1.0	0.3	0.7
Tense / ‘highly strung’	0.3	0.5	0.8	-0.7	-0.9	-0.5
Peak expiratory flow (PEF)	0.3	0.7	1.2	0.9	1.1	0.4
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.5	0.7	0.6	-0.3
Comparative body size at age 10	0.3	0.9	1.8	1.0	1.3	0.2
Medication: Omeprazole	0.3	0.4	0.6	0.8	0.6	0.4
Suffer from ‘nerves’	0.3	0.4	0.9	1.0	0.6	0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.6	-0.8	-0.3	-0.6
Diabetes diagnosed by doctor	0.3	0.5	1.1	0.5	0.3	1.1
Financial situation satisfaction	0.3	0.4	1.0	0.3	1.0	-0.3
Medication: Lisinopril	0.3	0.4	0.6	-0.2	-0.7	0.8
Myopia	0.3	0.5	1.4	-0.3	-0.2	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.5	-0.7	-0.7	0.0
Heart disease (siblings)	0.3	0.3	0.8	0.1	-0.9	-0.5
Pack years of smoking	0.3	0.4	0.9	0.5	1.0	-0.0
Crohns Disease (2017)	0.2	0.4	0.6	-0.8	-0.8	0.3
Triglycerides	0.2	0.3	0.3	0.6	0.6	0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	0.4	-0.0	0.7
Systolic blood pressure, automated reading	0.2	0.4	0.9	-0.5	-0.4	-0.9
Medication: Co-codamol	0.2	0.2	0.6	0.2	0.3	0.8
Diabetes (mother)	0.2	0.2	0.6	-0.8	-0.2	-0.3
Taking other prescription medications	0.2	0.3	0.6	0.4	-0.1	0.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	0.5	0.4	-0.4
Trunk fat mass	0.2	0.8	1.1	-1.1	-0.9	-0.6
Time employed in main current job	0.2	0.2	0.2	-0.5	-0.4	-0.4
Father’s age at death	0.2	0.3	0.3	0.6	0.6	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.5	-0.2	-0.7	-0.5
Lung cancer (father)	0.2	0.2	0.3	-0.5	-0.0	-0.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	-0.3	-0.3	-0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.3	-0.2	-0.6	-0.5
Eye problems/disorders: None of the above	0.2	0.2	0.6	-0.2	-0.0	-0.7
Medication: Allopurinol	0.2	0.2	0.3	0.5	0.4	0.4
Mean time to correctly identify matches	0.2	0.4	0.9	0.5	-0.2	1.0
Chest pain or discomfort	0.2	0.2	0.6	0.8	0.1	-0.2
Long-standing illness, disability or infirmity	0.2	0.3	0.9	1.0	0.1	0.1
Eye problems/disorders: Cataract	0.2	0.2	0.4	-0.5	-0.6	0.3
Breast cancer (self-reported)	0.2	0.3	0.6	-0.5	-0.7	-0.1
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	-0.7	-0.3	0.1
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.4	-0.2	-0.6	-0.6
High cholesterol (Self-reported)	0.2	0.4	1.1	-1.0	-0.5	-0.1
Ever depressed for a whole week	0.2	0.3	0.7	0.3	0.8	0.1
Unable to work because of sickness or disability	0.2	0.3	0.6	0.8	0.4	-0.3
Commuting to job workplace: Cycle	0.2	0.3	0.7	0.8	0.2	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.6	0.8	0.4	0.2
Supplements: Calcium	0.2	0.2	0.3	0.5	0.3	-0.5
Bipolar Disorder (2018)	0.1	0.2	0.4	0.7	-0.1	0.5
Worry (Nagel 2018)	0.1	0.2	0.6	0.1	-0.2	-0.8
Fasting Glucose	0.1	0.1	0.2	0.2	-0.3	0.4
HbA1C	0.1	0.1	0.2	-0.4	-0.3	0.4
Systolic Blood Pressure	0.1	0.5	0.8	-0.5	-0.7	-0.9
Cardiovascular Disease	0.1	0.2	0.3	0.5	0.4	0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.3	-0.3	0.2	0.6
Lung FEV1/FVC ratio	0.1	0.4	0.7	0.8	0.6	-0.0
Average weekly spirits intake	0.1	0.1	0.2	0.5	0.2	0.4
Hearing difficulty/problems: Yes	0.1	0.1	0.3	0.4	0.5	0.2
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.0	-0.2	0.4
Medication: Metformin	0.1	0.2	0.3	-0.4	-0.5	-0.1
Diabetes (father)	0.1	0.1	0.3	-0.5	-0.2	0.2
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.6	0.5	0.2
Qualifications: CSEs or equivalent	0.1	0.2	0.4	-0.2	-0.4	-0.6
Waist circumference	0.1	0.4	0.4	0.6	0.6	0.7
Past tobacco smoking	0.1	0.1	0.3	-0.5	0.0	0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	0.1	-0.0	-0.6
Hip circumference	0.1	0.5	0.5	0.7	0.7	0.7
Number of live births	0.1	0.1	0.4	-0.0	-0.1	0.6
Pulse rate	0.1	0.2	0.3	0.5	0.4	0.2
Noisy workplace	0.1	0.1	0.2	-0.2	-0.5	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.1	-0.4	-0.3
Standing height	0.1	0.6	1.6	1.3	-0.1	0.1
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.0	0.3	0.5
Birth weight of first child	0.1	0.1	0.1	0.4	-0.3	-0.3
Medication: Amlodipine	0.1	0.2	0.3	0.3	0.5	0.5
Number of full brothers	0.1	0.1	0.3	0.1	-0.0	-0.6
Pulse wave peak to peak time	0.1	0.1	0.3	0.2	0.3	0.6
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	0.3	-0.1	-0.5
Overall health rating	0.1	0.3	0.6	-0.2	-0.4	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	-0.1	-0.5	-0.3
Illnesses of siblings: Diabetes	0.1	0.2	0.3	-0.5	-0.4	-0.1
Smoking status: Previous	0.1	0.1	0.3	0.5	0.2	0.1
Arm fat percentage (left)	0.1	0.6	1.3	-1.1	-0.6	-0.3
Average weekly red wine intake	0.1	0.2	0.6	0.7	0.2	-0.1
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.3	-0.5	0.1
Back pain experienced in last month	0.1	0.2	0.5	0.3	-0.2	-0.7
Arm fat mass (left)	0.1	0.3	0.3	0.3	0.6	0.6
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.7	-0.5	0.2
Average weekly champagne plus white wine intake	0.1	0.1	0.1	-0.2	-0.4	0.4
Wears glasses or contact lenses	0.1	0.1	0.2	-0.4	0.0	-0.2
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.1	-0.2	0.4	0.3
Medication: Atorvastatin	0.1	0.1	0.2	-0.1	0.4	0.2
Alcohol drinker status: Never	0.1	0.1	0.4	-0.6	0.1	0.1
Ever smoked	0.1	0.2	0.6	0.2	-0.1	-0.8
Cholesterol lowering medication	0.1	0.2	0.5	-0.7	0.0	-0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.1	0.0	-0.1	0.3
Alzheimer’s Disease (in father)	0.0	0.0	0.1	0.3	-0.1	-0.2
Ovarian Cancer	0.0	0.0	0.0	-0.1	-0.0	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Height	0.0	0.6	1.1	0.6	-1.1	-0.4
Hair Pigment	0.0	0.6	1.3	-0.0	1.2	0.7
Tanning	0.0	0.1	0.1	-0.3	0.3	-0.2
Supplements: Zinc	0.0	0.0	0.0	-0.1	-0.1	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	0.1	0.2	0.3
Had menopause	0.0	0.0	0.0	0.2	0.1	0.1
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	0.3	0.0	0.2
Arm fat mass (right)	0.0	0.1	0.1	0.0	0.3	0.3
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.1	-0.2	-0.5
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	0.2	0.3	-0.0
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.0	-0.2	0.0	-0.0
Gout (self-reported)	0.0	0.0	0.0	-0.0	0.0	-0.2
Exposure to tobacco smoke outside home	0.0	0.0	0.0	-0.1	0.1	0.1
Whole body fat mass	0.0	0.1	0.1	-0.3	-0.1	0.2
Leg fat mass (right)	0.0	0.0	0.0	-0.2	0.1	0.1
Pulse rate, automated reading	0.0	0.1	0.2	0.5	0.2	0.1
Loneliness, isolation	0.0	0.0	0.0	0.2	-0.1	0.2
Osteoporosis (self-reported)	0.0	0.1	0.1	-0.3	0.1	0.3
Age started oral contraceptive pill	0.0	0.0	0.1	-0.0	-0.3	-0.1
Leg fat mass (left)	0.0	0.1	0.2	-0.5	-0.1	0.0

Hub : Genes

ZNF292

Models

Trait associations