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chr12:55,677,395-57,844,049

Best TWAS P=3.83e-14 · Best GWAS P=5.16e-13 conditioned to 0.13

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Breast Mammary Tissue (Female)	RPS26	0.20	0.11	lasso	3	0.10	6.6e-04	5.8	7.6	3.8e-14	0.84	0.01	0.86	TRUE
1	CommonMind	Brain Pre-frontal Cortex	PRIM1	0.31	0.24	enet	7	0.24	1.1e-28	5.0	-5.2	1.9e-07	-0.01	0.01	0.99	TRUE
14	GTEx	Prostate	SUOX	0.22	0.04	enet	11	0.05	2.3e-02	5.7	-6.6	3.1e-11	-0.67	0.09	0.43	FALSE
13	GTEx	Muscle Skeletal	AC034102.1	0.28	0.31	lasso	4	0.31	2.3e-31	6.5	-6.5	6.8e-11	-0.66	0.19	0.81	FALSE
11	GTEx	Muscle Skeletal	RAB5B	0.29	0.32	lasso	4	0.33	1.3e-33	6.4	-6.5	7.0e-11	-0.66	0.19	0.81	FALSE
46	The Cancer Genome Atlas	Skin Cutaneous Melanoma	RPS26	0.28	0.15	lasso	2	0.17	3.0e-05	6.4	6.4	1.9e-10	0.69	0.01	0.96	FALSE
40	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RPS26	0.30	0.20	lasso	4	0.24	3.9e-16	5.9	6.3	2.7e-10	0.67	0.04	0.96	FALSE
5	GTEx	Breast Mammary Tissue	RPS26	0.29	0.05	enet	37	0.12	9.4e-07	5.9	6.3	2.9e-10	0.63	0.23	0.77	FALSE
17	GTEx	Spleen	SUOX	0.34	0.31	enet	15	0.28	5.4e-08	5.8	-6.2	5.1e-10	-0.65	0.14	0.75	FALSE
29	The Cancer Genome Atlas	Colon Adenocarcinoma	RPS26	0.43	0.48	lasso	4	0.47	1.8e-30	5.9	6.1	1.1e-09	0.65	0.17	0.83	FALSE
48	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RPS26	0.46	0.64	lasso	4	0.65	8.5e-30	5.9	6.1	1.2e-09	0.64	0.22	0.78	FALSE
39	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RPS26	0.22	0.31	lasso	3	0.31	1.6e-35	5.9	6.1	1.3e-09	0.65	0.18	0.82	FALSE
28	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RPS26	0.23	0.40	lasso	2	0.39	1.5e-20	5.9	6.0	1.7e-09	0.64	0.16	0.84	FALSE
33	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RPS26	0.27	0.38	enet	8	0.40	5.0e-24	5.9	6.0	1.9e-09	0.66	0.20	0.80	FALSE
30	The Cancer Genome Atlas	Esophageal Carcinoma	RPS26	0.19	0.13	lasso	5	0.11	2.4e-04	5.9	6.0	2.0e-09	0.65	0.01	0.96	FALSE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	RPS26	0.26	0.45	enet	9	0.47	3.6e-61	5.9	6.0	2.2e-09	0.66	0.23	0.77	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPS26	0.33	0.52	enet	9	0.54	5.6e-66	5.9	6.0	2.2e-09	0.65	0.19	0.81	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RPS26	0.48	0.62	lasso	5	0.63	5.9e-99	5.9	6.0	2.3e-09	0.64	0.89	0.11	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPS26	0.30	0.44	enet	10	0.45	5.2e-104	5.9	6.0	2.5e-09	0.64	0.18	0.82	FALSE
45	The Cancer Genome Atlas	Soft Tissue Sarcoma	RPS26	0.23	0.31	lasso	3	0.30	2.4e-18	5.9	5.9	2.8e-09	0.64	0.18	0.82	FALSE
50	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	RPS26	0.17	0.19	lasso	4	0.18	1.3e-05	5.9	5.9	2.9e-09	0.67	0.03	0.95	FALSE
16	GTEx	Skin Sun Exposed Lower leg	SUOX	0.23	0.30	lasso	3	0.29	1.9e-24	5.8	-5.9	3.0e-09	-0.68	0.93	0.07	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	RPS26	0.31	0.53	enet	8	0.55	1.7e-74	5.9	5.9	3.4e-09	0.65	0.26	0.74	FALSE
44	The Cancer Genome Atlas	Rectum Adenocarcinoma	RPS26	0.24	0.18	lasso	2	0.20	1.9e-05	5.9	5.9	3.7e-09	0.66	0.05	0.57	FALSE
20	GTEx	Testis	SUOX	0.27	0.18	lasso	14	0.18	1.4e-08	5.8	-5.9	3.8e-09	-0.67	0.61	0.39	FALSE
42	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RPS26	0.47	0.43	lasso	2	0.44	3.2e-19	5.7	5.9	4.5e-09	0.67	0.24	0.76	FALSE
21	GTEx	Thyroid	SUOX	0.37	0.40	lasso	7	0.38	5.4e-31	5.8	-5.9	4.6e-09	-0.70	0.92	0.08	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	SUOX	0.20	0.16	lasso	5	0.19	2.7e-07	5.7	-5.8	5.1e-09	-0.66	0.54	0.40	FALSE
36	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RPS26	0.18	0.31	lasso	2	0.29	3.9e-14	5.9	5.8	5.3e-09	0.63	0.21	0.79	FALSE
19	GTEx	Stomach	RPS26	0.16	0.08	enet	5	0.05	1.8e-03	5.8	5.8	6.2e-09	0.61	0.10	0.46	FALSE
47	The Cancer Genome Atlas	Stomach Adenocarcinoma	RPS26	0.19	0.32	lasso	5	0.34	2.0e-25	5.5	5.8	6.8e-09	0.63	0.41	0.59	FALSE
4	GTEx	Brain Cortex	SUOX	0.16	0.11	lasso	4	0.10	1.1e-03	5.8	-5.8	7.8e-09	-0.68	0.07	0.29	FALSE
22	GTEx	Whole Blood	RPS26	0.05	0.05	lasso	1	0.05	3.4e-05	5.7	5.7	9.7e-09	0.68	0.20	0.71	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	SUOX	0.10	0.14	lasso	2	0.12	2.5e-07	5.8	-5.7	1.1e-08	-0.67	0.42	0.52	FALSE
24	METSIM	Adipose	RPS26	0.30	0.40	lasso	5	0.41	7.2e-66	5.5	5.7	1.1e-08	0.62	0.94	0.06	FALSE
31	The Cancer Genome Atlas	Glioblastoma Multiforme	RPS26	0.41	0.38	enet	9	0.39	7.9e-13	5.5	5.7	1.1e-08	0.63	0.28	0.72	FALSE
3	GTEx	Artery Tibial	RPS26	0.07	0.02	enet	5	0.01	3.5e-02	5.9	5.7	1.3e-08	0.65	0.22	0.23	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RPS26	0.17	0.29	lasso	4	0.29	6.2e-33	5.5	5.7	1.3e-08	0.63	0.42	0.57	FALSE
9	GTEx	Esophagus Muscularis	SUOX	0.24	0.19	enet	16	0.15	2.3e-09	5.8	-5.6	1.8e-08	-0.62	0.92	0.08	FALSE
23	METSIM	Adipose	IKZF4	0.04	0.04	enet	3	0.04	1.0e-06	5.5	5.6	1.9e-08	0.61	0.95	0.04	FALSE
26	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RPS26	0.14	0.22	lasso	2	0.23	4.8e-19	5.5	5.6	1.9e-08	0.62	0.41	0.59	FALSE
41	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RPS26	0.36	0.44	lasso	7	0.42	2.4e-19	5.5	5.6	2.3e-08	0.64	0.40	0.60	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	ERBB3	0.07	0.02	blup	29	0.05	2.1e-06	6.5	5.6	2.5e-08	0.39	0.00	1.00	FALSE
7	GTEx	Colon Sigmoid	SUOX	0.23	0.18	lasso	4	0.15	7.9e-06	5.8	-5.5	4.4e-08	-0.64	0.33	0.63	FALSE
12	GTEx	Muscle Skeletal	SUOX	0.11	0.04	lasso	7	0.04	4.4e-05	5.8	-5.4	6.0e-08	-0.67	0.28	0.64	FALSE
10	GTEx	Heart Atrial Appendage	SUOX	0.09	0.10	enet	8	0.09	1.1e-04	5.9	-5.4	6.3e-08	-0.68	0.13	0.65	FALSE
25	YFS	Blood	SUOX	0.11	0.09	bslmm	269	0.09	3.4e-27	5.7	-5.4	6.4e-08	-0.65	0.94	0.06	FALSE
18	GTEx	Stomach	SUOX	0.15	0.17	enet	8	0.09	6.7e-05	5.8	-5.4	7.1e-08	-0.65	0.65	0.28	FALSE
37	The Cancer Genome Atlas	Lung Adenocarcinoma	RAB5B	0.03	0.02	enet	7	0.02	4.3e-03	6.4	5.3	9.4e-08	0.57	0.02	0.32	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	RPS26	0.33	0.51	enet	19	0.50	7.3e-56	5.9	5.3	1.4e-07	0.64	0.18	0.82	FALSE