TWAS hub - AKT1S1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.103	0.0283	2.2e-06	0.087	NA	0.064	NA	0.082	6.5e-09	NA	6.4e-07	NA	1.9e-08
2	GTEx	Spleen	0.347	0.1430	9.9e-03	0.069	NA	0.126	NA	0.116	7.8e-03	NA	4.0e-04	NA	6.8e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Migraine (self-reported)	5.5	6.8	12.9	3.6	0.8
Tinnitus: Yes, but not now, but have in the past	4.8	5.2	10.0	-0.6	-3.2
Medication: Lansoprazole	4.6	5.2	8.4	-2.9	-1.4
Alzheimer’s Disease (in mother)	4.5	5.3	10.3	0.5	3.2
Medication: Metformin	4.5	6.3	9.9	-3.2	-1.7
Medication: Ibuprofen (e.g. Nurofen)	4.4	5.6	8.9	3.0	-1.5
Back pain experienced in last month	4.4	6.5	9.9	1.7	-3.1
Impedance of arm (left)	4.2	19.2	33.8	-5.8	2.2
Impedance of whole body	4.1	21.1	37.9	-6.2	2.1
Impedance of arm (right)	3.8	17.8	31.0	-5.6	2.1
Had menopause	3.7	4.7	9.2	-3.0	-0.4
Tinnitus: Yes, now most or all of the time	3.7	4.3	8.0	0.8	2.8
Ever had prostate specific antigen (PSA) test	3.7	4.3	4.9	1.9	-2.2
Medication: Ibuprofen	3.6	4.3	7.6	2.8	-1.0
Length of working week for main job	3.5	3.8	5.0	-2.2	1.6
Ever had bowel cancer screening	3.4	4.0	5.2	-1.7	2.3
Impedance of leg (right)	3.3	15.8	29.7	-5.5	1.4
Emphysema/chronic bronchitis	3.3	3.7	4.5	-1.7	2.1
Qualifications: O levels/GCSEs or equivalent	3.2	5.1	7.6	2.8	1.6
Trunk fat-free mass	3.0	17.2	34.0	5.8	-0.7
Trunk predicted mass	3.0	17.1	33.8	5.8	-0.7
Age at First Birth	2.9	4.3	6.0	-2.5	-1.6
Frequency of tenseness / restlessness in last 2 weeks	2.9	4.5	8.0	-2.8	0.9
Diabetes diagnosed by doctor	2.9	4.8	6.0	-2.4	-1.9
Diabetes (self-reported)	2.8	4.4	6.2	-2.5	-1.6
Arm predicted mass (left)	2.7	13.6	26.3	5.1	-1.0
Impedance of leg (left)	2.5	12.0	21.3	-4.6	1.7
Qualifications: A levels/AS levels or equivalent	2.5	5.4	9.0	3.0	1.4
Relative age voice broke	2.4	3.6	5.9	-2.4	-1.2
Allergy	2.4	5.6	11.2	3.3	-0.1
Leg pain on walking	2.4	3.1	4.5	2.1	-1.3
Whole body fat-free mass	2.4	13.6	26.8	5.2	-0.6
Whole body water mass	2.4	13.7	26.9	5.2	-0.7
Average weekly champagne plus white wine intake	2.4	3.3	4.1	-2.0	1.6
Arm fat-free mass (left)	2.4	12.2	23.8	4.9	-0.8
Prospective memory result	2.3	2.8	4.9	2.2	-0.8
Arm fat-free mass (right)	2.3	11.6	22.1	4.7	-1.1
Arm predicted mass (right)	2.3	11.6	22.2	4.7	-1.0
Commuting to job workplace: Cycle	2.3	2.8	5.1	-2.3	0.7
Gout (self-reported)	2.2	3.0	6.0	-0.2	-2.5
Alzheimer’s Disease (including proxy)	2.1	3.0	6.0	0.2	2.5
Medication: Ramipril	2.1	2.8	4.5	-2.1	1.0
Medication: Allopurinol	2.1	2.8	5.2	0.7	-2.3
Medication: Co-codamol	2.0	2.4	4.6	-0.4	-2.1
Hayfever/allergic rhinitis (self-reported)	2.0	2.6	5.2	-0.2	-2.3
Lupus	1.9	2.9	5.8	0.1	-2.4
Current tobacco smoking	1.9	3.1	6.1	2.5	0.2
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	3.9	0.7	-2.0
Basal metabolic rate	1.9	10.4	20.5	4.5	-0.6
Diastolic blood pressure, automated reading	1.9	6.0	6.1	2.5	-2.4
Mouth/teeth dental problems	1.8	2.8	5.5	2.4	0.4
Chronic bronchitis/emphysema (mother)	1.8	2.1	2.2	-1.5	-1.4
Leg fat-free mass (right)	1.8	9.4	18.6	4.3	-0.4
Smoking status: Current	1.8	2.8	5.6	2.4	0.2
Sitting height	1.7	11.7	21.6	4.6	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.3	8.2	2.9	1.5
Hair/balding pattern: Pattern 4	1.7	4.0	4.2	-2.1	2.0
Worry too long after embarrassment	1.7	2.8	4.7	-2.2	-1.0
Pulse wave peak to peak time	1.7	2.0	2.5	-1.2	1.6
Mouth/teeth dental problems: Loose teeth	1.7	2.0	3.9	-2.0	0.3
Mean time to correctly identify matches	1.7	3.3	4.4	-2.1	-1.4
Leg predicted mass (right)	1.7	9.3	18.6	4.3	-0.3
Supplements: Calcium	1.7	1.8	1.9	-1.3	-1.4
Depressed Affect (Nagel 2018)	1.6	3.3	6.1	-0.7	2.5
Diabetes (father)	1.6	2.0	3.2	-1.8	-0.9
Qualifications: CSEs or equivalent	1.6	2.1	2.5	1.3	-1.6
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	3.5	-1.9	-0.8
Forced vital capacity (FVC), Best measure	1.6	6.0	7.0	2.6	2.2
Loneliness, isolation	1.6	2.1	4.2	-0.4	2.0
Myopia	1.6	2.4	3.5	-1.9	-1.1
Allergy or Eczema	1.5	3.9	7.5	-2.7	-0.6
Neuroticism	1.5	3.7	7.0	-2.6	0.7
Medication: Atenolol	1.5	1.9	3.2	1.8	-0.8
Forced vital capacity (FVC)	1.5	5.9	8.8	3.0	1.7
Peak expiratory flow (PEF)	1.5	3.4	5.6	2.4	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	1.8	1.3	-1.4
Medication for pain relief, constipation, heartburn	1.5	2.6	3.1	-1.4	1.8
Age started oral contraceptive pill	1.5	1.9	3.5	-0.5	-1.9
Basal cell carcinoma (self-reported)	1.5	1.8	3.3	-1.8	0.5
Intelligence (Savage-Jansen 2018)	1.4	4.2	8.1	-0.5	2.8
Verbal and Numeric Reasoning (VNR)	1.4	3.4	4.1	-1.7	2.0
Respiratory disease	1.4	3.0	5.8	-2.4	-0.5
Supplements: Zinc	1.4	1.5	1.7	-1.1	-1.3
High blood pressure (mother)	1.4	2.0	4.0	0.1	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.3	3.8	2.0	1.6
Financial difficulties in last 2 years	1.4	1.8	2.9	-0.9	-1.7
Forced expiratory volume in 1-second (FEV1)	1.4	4.8	8.7	3.0	0.9
Pulse wave Arterial Stiffness index	1.4	1.6	1.6	1.2	-1.3
Hearing aid user	1.4	1.5	2.9	0.4	1.7
Illnesses of father: High blood pressure	1.4	1.7	3.4	1.8	-0.3
Body Mass Index (BMI) (2010)	1.3	1.8	3.3	0.6	-1.8
Ever used hormone-replacement therapy (HRT)	1.3	1.7	2.0	-1.1	-1.4
Leg fat-free mass (left)	1.3	6.6	13.1	3.6	-0.4
Number of incorrect matches in round	1.3	2.2	3.0	-1.7	1.2
Father’s age at death	1.3	1.7	2.3	-1.1	-1.5
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.6	3.0	-1.7	-0.3
Number of full sisters	1.3	1.6	3.2	-0.1	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	2.5	-1.6	0.7
Friendships satisfaction	1.3	1.7	1.9	-1.2	-1.4
Commuting to job workplace: Walk	1.3	1.4	2.9	-1.7	0.1
Financial situation satisfaction	1.3	1.6	1.8	-1.2	1.4
Average weekly beer plus cider intake	1.3	1.8	3.3	0.6	-1.8
Ever depressed for a whole week	1.3	1.6	3.0	-0.4	1.7
Schizophrenia (2018)	1.2	2.5	3.9	1.0	-2.0
Worry (Nagel 2018)	1.2	2.6	4.8	-2.2	0.5
Blood Red Count	1.2	11.2	15.9	-2.5	4.0
Smoking Status	1.2	2.9	3.1	1.7	1.7
Type 2 Diabetes (T2D) (2018)	1.2	2.2	2.3	-1.5	-1.5
Relative age of first facial hair	1.2	2.5	2.7	-1.5	-1.6
Leg predicted mass (left)	1.2	6.5	12.8	3.6	-0.4
Pain all over the body in last month	1.2	1.2	1.4	-1.2	-1.1
Fluid intelligence score	1.2	2.6	3.3	-1.8	1.4
Happiness	1.2	1.4	2.6	0.5	-1.6
Asthma	1.2	2.3	4.5	-2.1	-0.4
Heart disease (mother)	1.2	1.5	2.9	0.1	-1.7
Qualifications: nursing, teaching	1.2	1.9	3.2	1.8	-0.7
Neuroticism (Nagel 2018)	1.1	2.6	4.2	-2.0	1.1
Medication: Cholesterol lowering	1.1	1.7	2.8	-1.7	0.7
Number of full brothers	1.1	1.3	1.7	1.3	1.0
Alcohol intake frequency.	1.1	2.6	3.3	1.8	1.4
Had major operations	1.1	1.3	1.8	-1.4	-0.9
Commuting to job workplace: Car/motor vehicle	1.1	1.2	1.9	1.4	-0.7
Illnesses of siblings: Diabetes	1.1	1.4	2.2	-1.5	-0.8
Average weekly red wine intake	1.1	1.6	3.1	-1.8	0.3
Asthma (self-reported)	1.1	2.2	4.1	-2.0	-0.5
Medication: Gliclazide	1.1	1.3	2.4	-1.6	0.4
Ever had hysterectomy (womb removed)	1.0	1.1	1.5	-1.2	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	2.3	1.5	1.5
Alcohol usually taken with meals	1.0	1.6	1.7	-1.3	-1.3
Pulse rate	1.0	1.7	3.0	1.7	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	1.5	-0.9	-1.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	2.5	-0.1	1.6
Miserableness	1.0	1.7	2.3	1.0	1.5
HDL Cholesterol	0.9	1.5	2.6	-0.7	1.6
Neuroticism (2016)	0.9	1.2	1.3	-1.2	1.1
Schizophrenia (2014)	0.9	1.9	2.5	1.1	-1.6
Systolic blood pressure, automated reading	0.9	2.7	3.6	1.3	-1.9
Hand grip strength (right)	0.9	2.4	4.6	2.1	-0.5
Loud music exposure frequency	0.9	1.0	1.6	-0.6	-1.2
Leg fat percentage (right)	0.9	3.2	5.5	-2.3	-1.0
Suffer from ‘nerves’	0.9	1.4	2.8	-1.7	-0.2
Pain experienced in last month	0.9	1.5	2.7	-0.7	1.6
Reaction Time	0.8	1.6	2.5	-0.8	-1.6
Systolic Blood Pressure	0.8	4.1	6.7	2.6	-1.3
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.5	-1.2	-0.5
Medication for hormone replacement therapy	0.8	0.9	1.0	1.0	0.9
Vitamin and mineral supplements	0.8	1.0	1.3	1.1	0.9
Trunk fat percentage	0.8	3.3	6.6	-2.6	0.1
Average weekly fortified wine intake	0.8	1.0	1.6	0.6	-1.3
Taking other prescription medications	0.8	1.2	1.5	-0.9	-1.2
Hayfever, allergic rhinitis or eczema	0.8	1.7	2.7	-1.6	-0.9
Chronic bronchitis/emphysema (father)	0.8	0.9	1.7	-0.5	-1.3
Medication: Simvastatin	0.8	1.1	1.9	-1.4	0.6
Headache pain in last month	0.8	1.4	2.7	1.6	0.2
Pulse rate, automated reading	0.8	2.7	5.2	0.5	-2.3
Eye problems/disorders: Cataract	0.8	0.9	1.5	1.2	-0.6
Guilty feelings	0.8	1.1	1.7	-1.3	0.8
Wears glasses or contact lenses	0.8	0.9	1.7	-1.3	-0.4
Medication: Paracetamol	0.8	1.2	2.4	0.1	-1.5
Medication: Atorvastatin	0.8	1.0	1.6	-0.7	1.3
Breast Cancer	0.7	1.6	2.1	-1.4	-1.1
Past tobacco smoking	0.7	1.2	1.7	-0.8	-1.3
Had other major operations	0.7	0.9	1.3	1.2	-0.7
Mouth/teeth dental problems: Dentures	0.7	1.3	2.2	-1.5	0.6
Body fat percentage	0.7	2.9	5.7	-2.4	-0.2
Overall health rating	0.7	1.4	1.9	-1.4	-1.0
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.4	1.2	0.6
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.8	0.2	1.3
Unable to work because of sickness or disability	0.7	0.9	1.8	-1.3	0.1
Bipolar Disorder or Schizophrenia	0.6	1.4	1.5	1.2	-1.2
Ulcerative Colitis	0.6	0.8	1.5	-1.2	0.4
Hearing difficulty/problems with background noise	0.6	1.0	1.3	-0.8	-1.1
Neuroticism score	0.6	1.2	2.3	-1.5	-0.3
Illnesses of mother	0.6	0.8	1.5	0.3	1.2
Exposure to tobacco smoke at home	0.6	0.7	1.4	-1.2	-0.2
Breastfed as a baby	0.6	0.7	0.7	-0.8	0.9
Tense / ‘highly strung’	0.6	0.9	1.5	-1.2	0.6
Medication: Paracetamol	0.6	0.9	1.8	0.3	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.4	0.4	-1.2
Eye problems/disorders: None of the above	0.6	0.7	0.8	-0.8	0.9
Comparative height size at age 10	0.6	3.3	5.5	2.4	1.0
Commuting to job workplace: Public transport	0.6	0.7	1.1	-0.6	1.0
Alzheimer’s Disease (in father)	0.5	0.6	1.2	0.0	-1.1
Ulcerative Colitis (UC)	0.5	1.0	1.9	0.3	1.4
Height	0.5	10.2	11.4	3.4	3.0
Hypothyroidism (self reported)	0.5	1.2	1.5	-1.2	1.0
Sensitivity / hurt feelings	0.5	0.9	1.1	-1.0	-0.8
Hearing difficulty/problems: Yes	0.5	0.8	1.4	1.2	-0.2
Maternal smoking around birth	0.5	0.7	1.1	0.7	1.0
Multivitamins +/- minerals	0.5	0.6	1.2	-0.2	-1.1
Heart attack	0.5	0.6	0.8	-0.9	0.6
Weight	0.5	2.5	4.7	2.2	-0.6
Time employed in main current job	0.5	0.5	0.6	-0.8	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.6	0.4	-1.3
Falls in the last year	0.5	0.6	0.8	-0.6	0.9
Standing height	0.5	5.2	7.4	2.7	1.7
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.5	1.2	-0.2
Birth weight	0.5	1.1	2.0	1.4	-0.4
Age at last live birth	0.5	0.8	1.6	-0.2	-1.2
Family relationship satisfaction	0.5	0.6	1.2	-1.1	-0.2
Mood swings	0.5	1.0	1.4	-0.8	1.2
Long-standing illness, disability or infirmity	0.5	0.8	1.5	0.1	-1.2
Breast cancer (self-reported)	0.5	0.6	1.2	1.1	-0.0
Osteoporosis (self-reported)	0.5	0.6	0.7	-0.8	-0.7
Ever taken oral contraceptive pill	0.5	0.6	0.7	-0.8	0.7
Leg fat percentage (left)	0.5	1.8	2.8	-1.7	-0.9
Number of operations (self-reported)	0.5	0.8	1.6	-1.3	0.1
Pack years adult smoking proportion	0.4	0.6	1.2	1.1	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.0	-1.0	-0.1
Stomach or abdominal pain in last month	0.4	0.5	0.9	1.0	-0.1
Body mass index (BMI)	0.4	1.8	2.1	1.2	-1.5
Nervous feelings	0.4	0.8	1.4	-1.2	-0.4
Qualifications: None of the above	0.4	0.9	1.3	-1.1	-0.6
Alcohol intake versus 10 years previously	0.4	0.6	1.0	-0.5	1.0
Exposure to tobacco smoke outside home	0.4	0.5	0.9	-0.9	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	0.2	1.0
Supplements: Vitamin C	0.4	0.5	0.9	-0.9	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.4	0.1	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.0	-1.0	-0.2
Osteoarthritis (self-reported)	0.4	0.5	1.0	1.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.4	1.2	0.3
Number of self-reported non-cancer illnesses	0.4	0.8	1.4	0.3	-1.2
Alcohol drinker status: Never	0.4	0.4	0.8	0.9	0.2
Ever smoked	0.4	0.8	1.3	1.2	0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	-1.0	0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.8	-0.9	0.5
Pack years of smoking	0.4	0.5	1.1	1.0	0.1
Irritable Bowel Disease (IBD)	0.3	0.6	1.3	0.0	1.1
Ovarian Cancer	0.3	0.3	0.7	0.8	-0.1
Primary Biliary Cirrhosis	0.3	0.5	0.9	0.3	-1.0
Rheumatoid Arthritis	0.3	0.5	0.5	-0.7	-0.6
Blood Eosinophil Count	0.3	2.4	4.1	-0.8	-2.0
Blood White Count	0.3	2.0	2.2	1.3	1.5
BMI	0.3	1.9	3.4	1.8	-0.7
Hand grip strength (left)	0.3	0.9	1.7	1.3	0.2
Average weekly spirits intake	0.3	0.4	0.7	-0.8	-0.4
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	0.8	-0.3
Angina	0.3	0.4	0.7	0.8	0.1
Fed-up feelings	0.3	0.6	1.1	-1.1	0.1
Serious illness, injury or assault to yourself	0.3	0.3	0.4	0.5	-0.6
Supplements: Glucosamine	0.3	0.3	0.6	-0.3	-0.8
Medication: Levothyroxine sodium	0.3	0.5	1.0	-1.0	0.1
Illnesses of siblings	0.3	0.4	0.7	-0.1	0.9
Birth weight of first child	0.3	0.6	0.8	-0.9	-0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.6	-0.5	-0.8
High blood pressure (siblings)	0.3	0.4	0.8	0.1	-0.9
Wheeze or whistling in the chest in last year	0.3	0.5	0.9	0.2	-0.9
Angina (self-reported)	0.3	0.4	0.7	0.9	0.3
Chest pain or discomfort	0.3	0.4	0.8	0.3	0.9
Smoking status: Previous	0.3	0.5	1.0	-0.2	1.0
Arm fat percentage (left)	0.3	1.1	1.9	-1.4	-0.6
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.5	-0.5	0.7
Mineral and other dietary supplements	0.3	0.4	0.5	0.6	-0.7
Illnesses of father: None of the above (group 1)	0.3	0.3	0.6	-0.7	0.3
Mother’s age at death	0.3	0.4	0.8	-0.9	0.2
Irritability	0.3	0.5	0.8	-0.9	-0.5
Cholesterol lowering medication	0.3	0.4	0.8	-0.3	0.9
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	-0.8	0.3
Bipolar Disorder (2018)	0.2	0.3	0.3	0.6	0.6
Prostate Cancer	0.2	0.3	0.3	-0.4	-0.6
Mean Putamen Volume	0.2	0.2	0.3	-0.2	-0.6
Fasting Glucose	0.2	0.2	0.4	0.6	0.1
Cardiovascular Disease	0.2	0.8	1.4	0.5	1.2
Lung FEV1/FVC ratio	0.2	1.2	1.6	0.8	-1.3
Lung FVC	0.2	1.1	1.5	0.9	1.2
Chronotype (morning person)	0.2	0.5	1.0	-1.0	-0.1
Hair Pigment	0.2	6.2	12.2	3.5	-0.2
Number of treatments/medications taken	0.2	0.4	0.8	0.1	-0.9
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.4	-0.3	-0.6
Diabetes (mother)	0.2	0.3	0.5	0.7	-0.3
Severe depression (siblings)	0.2	0.2	0.4	-0.6	-0.0
Townsend deprivation index at recruitment	0.2	0.3	0.4	-0.7	-0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	-0.6	-0.2
High blood pressure	0.2	0.6	1.1	-0.2	-1.0
Hair/balding pattern: Pattern 2	0.2	0.3	0.5	-0.2	0.7
Arm fat percentage (right)	0.2	0.7	1.1	-1.1	-0.5
Worrier / anxious feelings	0.2	0.3	0.6	-0.8	0.2
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	0.5	-0.6
Number of live births	0.2	0.3	0.4	-0.4	-0.6
Noisy workplace	0.2	0.3	0.5	-0.7	0.2
Depression (self-reported)	0.2	0.2	0.4	-0.6	-0.1
Arm fat mass (right)	0.2	0.6	0.7	0.9	-0.7
Pulse wave reflection index	0.2	0.2	0.3	0.6	-0.3
Blood clot in the leg (DVT)	0.2	0.2	0.3	-0.6	-0.3
Glaucoma (self-reported)	0.2	0.2	0.2	0.4	0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.7	-0.8	0.3
Age at first live birth	0.2	0.4	0.8	0.9	-0.2
Health satisfaction	0.2	0.3	0.3	-0.6	-0.5
Knee pain experienced in last month	0.2	0.3	0.7	-0.1	-0.8
Hypertension (Self-reported)	0.2	0.5	0.9	-0.4	-0.9
Illnesses of father: Heart disease	0.2	0.2	0.4	-0.2	-0.6
Medication for cholesterol	0.2	0.4	0.7	-0.8	-0.1
Medication: Aspirin	0.2	0.3	0.4	-0.5	-0.6
Arm fat mass (left)	0.2	0.7	0.9	0.9	-0.7
High cholesterol (Self-reported)	0.2	0.3	0.4	-0.6	0.6
Medication: Bendroflumethiazide	0.2	0.2	0.3	-0.4	-0.6
Medication: Lisinopril	0.2	0.2	0.4	-0.2	-0.6
Risk taking	0.2	0.3	0.5	-0.4	-0.7
Fractured/broken bones in last 5 years	0.2	0.3	0.5	-0.7	-0.3
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.0	0.3	1.0
Heart disease (siblings)	0.2	0.2	0.3	-0.6	-0.4
Alcohol drinker status: Previous	0.2	0.2	0.4	0.7	0.0
Crohns Disease (2017)	0.1	0.3	0.4	-0.3	0.6
Major Depression (MDD)	0.1	0.2	0.4	0.0	-0.6
Crohns Disease (2012)	0.1	0.2	0.3	-0.5	0.3
HbA1C	0.1	0.1	0.2	0.2	-0.4
LDL Cholesterol	0.1	0.1	0.2	-0.0	0.5
Blood Platelet Count	0.1	0.7	1.0	1.0	0.7
Tanning	0.1	0.9	1.2	-1.1	0.8
Age when periods started (menarche)	0.1	0.2	0.3	-0.5	0.2
Trunk fat mass	0.1	0.2	0.5	-0.7	-0.1
Waist circumference	0.1	0.2	0.3	0.5	-0.3
Hip circumference	0.1	0.3	0.4	0.7	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.2	-0.5	0.4
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.3	-0.2	-0.5
Medication: Amlodipine	0.1	0.2	0.3	0.1	-0.6
Comparative body size at age 10	0.1	0.2	0.3	0.3	0.5
Shortness of breath walking on level ground	0.1	0.1	0.2	0.3	-0.4
Qualifications: College or University degree	0.1	0.4	0.7	-0.4	0.8
Neck or shoulder pain in last month	0.1	0.1	0.3	0.5	-0.0
Medication: Blood pressure	0.1	0.2	0.4	-0.6	0.1
Medication: Omeprazole	0.1	0.1	0.1	-0.1	0.3
Leg fat mass (right)	0.1	0.3	0.6	-0.1	-0.7
Medication: Aspirin	0.1	0.1	0.2	-0.3	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.6	0.7	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	0.1	-0.4
Medication: Blood pressure	0.1	0.1	0.2	-0.1	-0.5
Leg fat mass (left)	0.1	0.2	0.4	0.2	-0.6
Depression (Nagel 2018)	0.0	0.0	0.1	0.2	0.1
Schizophrenia vs Biploar Disorder	0.0	0.1	0.1	0.1	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.0	0.2	0.3	0.2	0.6
Waist Hip Ratio (WHR)	0.0	0.2	0.4	0.0	0.7
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.0	0.2	0.0
Lung cancer (father)	0.0	0.0	0.0	-0.0	-0.1
Number of children fathered	0.0	0.0	0.1	-0.0	-0.3
Medication: Seretide 50 evohaler	0.0	0.0	0.1	-0.3	0.1
Whole body fat mass	0.0	0.2	0.2	-0.3	-0.5
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	0.3	0.2

Hub : Genes

AKT1S1

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Trait associations