Hub : Genes

AKT1S1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.103 0.0283 2.2e-06 0.087 NA 0.064 NA 0.082 6.5e-09 NA 6.4e-07 NA 1.9e-08
2 GTEx Spleen 0.347 0.1430 9.9e-03 0.069 NA 0.126 NA 0.116 7.8e-03 NA 4.0e-04 NA 6.8e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.2 0.3 0.3 0.6 0.6
Bipolar Disorder or Schizophrenia 0.6 1.4 1.5 1.2 -1.2
Depressed Affect (Nagel 2018) 1.6 3.3 6.1 -0.7 2.5
Depression (Nagel 2018) 0.0 0.0 0.1 0.2 0.1
Intelligence (Savage-Jansen 2018) 1.4 4.2 8.1 -0.5 2.8
Neuroticism (Nagel 2018) 1.1 2.6 4.2 -2.0 1.1
Schizophrenia (2018) 1.2 2.5 3.9 1.0 -2.0
Schizophrenia vs Biploar Disorder 0.0 0.1 0.1 0.1 0.3
Worry (Nagel 2018) 1.2 2.6 4.8 -2.2 0.5
Alzheimer’s Disease (in mother) 4.5 5.3 10.3 0.5 3.2
Alzheimer’s Disease (in father) 0.5 0.6 1.2 0.0 -1.1
Alzheimer’s Disease (including proxy) 2.1 3.0 6.0 0.2 2.5
Crohns Disease (2017) 0.1 0.3 0.4 -0.3 0.6
Irritable Bowel Disease (IBD) 0.3 0.6 1.3 0.0 1.1
Ulcerative Colitis (UC) 0.5 1.0 1.9 0.3 1.4
Major Depression (MDD) 0.1 0.2 0.4 0.0 -0.6
Reaction Time 0.8 1.6 2.5 -0.8 -1.6
Verbal and Numeric Reasoning (VNR) 1.4 3.4 4.1 -1.7 2.0
Breast Cancer 0.7 1.6 2.1 -1.4 -1.1
Ovarian Cancer 0.3 0.3 0.7 0.8 -0.1
Prostate Cancer 0.2 0.3 0.3 -0.4 -0.6
Age at First Birth 2.9 4.3 6.0 -2.5 -1.6
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.3 1.8 3.3 0.6 -1.8
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.1 0.2 0.3 -0.5 0.3
Mean Putamen Volume 0.2 0.2 0.3 -0.2 -0.6
Fasting Glucose 0.2 0.2 0.4 0.6 0.1
HbA1C 0.1 0.1 0.2 0.2 -0.4
HDL Cholesterol 0.9 1.5 2.6 -0.7 1.6
LDL Cholesterol 0.1 0.1 0.2 -0.0 0.5
Lupus 1.9 2.9 5.8 0.1 -2.4
Neuroticism (2016) 0.9 1.2 1.3 -1.2 1.1
Primary Biliary Cirrhosis 0.3 0.5 0.9 0.3 -1.0
Rheumatoid Arthritis 0.3 0.5 0.5 -0.7 -0.6
Schizophrenia (2014) 0.9 1.9 2.5 1.1 -1.6
Triglycerides 0.0 0.0 0.0 0.0 0.0
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.6 0.8 1.5 -1.2 0.4
Blood Eosinophil Count 0.3 2.4 4.1 -0.8 -2.0
Blood Platelet Count 0.1 0.7 1.0 1.0 0.7
Blood Red Count 1.2 11.2 15.9 -2.5 4.0
Blood White Count 0.3 2.0 2.2 1.3 1.5
Heel T-Score 0.0 0.2 0.3 0.2 0.6
BMI 0.3 1.9 3.4 1.8 -0.7
Height 0.5 10.2 11.4 3.4 3.0
Waist Hip Ratio (WHR) 0.0 0.2 0.4 0.0 0.7
Systolic Blood Pressure 0.8 4.1 6.7 2.6 -1.3
Smoking Status 1.2 2.9 3.1 1.7 1.7
Allergy or Eczema 1.5 3.9 7.5 -2.7 -0.6
Cardiovascular Disease 0.2 0.8 1.4 0.5 1.2
Hypothyroidism (self reported) 0.5 1.2 1.5 -1.2 1.0
Respiratory disease 1.4 3.0 5.8 -2.4 -0.5
Type 2 Diabetes (T2D) (2018) 1.2 2.2 2.3 -1.5 -1.5
Lung FEV1/FVC ratio 0.2 1.2 1.6 0.8 -1.3
Lung FVC 0.2 1.1 1.5 0.9 1.2
Neuroticism 1.5 3.7 7.0 -2.6 0.7
Chronotype (morning person) 0.2 0.5 1.0 -1.0 -0.1
Hair Pigment 0.2 6.2 12.2 3.5 -0.2
Tanning 0.1 0.9 1.2 -1.1 0.8
Hand grip strength (left) 0.3 0.9 1.7 1.3 0.2
Number of treatments/medications taken 0.2 0.4 0.8 0.1 -0.9
Average weekly spirits intake 0.3 0.4 0.7 -0.8 -0.4
Sensitivity / hurt feelings 0.5 0.9 1.1 -1.0 -0.8
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.4 -0.3 -0.6
Hearing difficulty/problems: Yes 0.5 0.8 1.4 1.2 -0.2
Relative age of first facial hair 1.2 2.5 2.7 -1.5 -1.6
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.7 0.8 -0.3
Ever used hormone-replacement therapy (HRT) 1.3 1.7 2.0 -1.1 -1.4
Ever had hysterectomy (womb removed) 1.0 1.1 1.5 -1.2 0.8
Systolic blood pressure, automated reading 0.9 2.7 3.6 1.3 -1.9
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 1.5 -1.2 -0.5
Angina 0.3 0.4 0.7 0.8 0.1
Medication for hormone replacement therapy 0.8 0.9 1.0 1.0 0.9
Vitamin and mineral supplements 0.8 1.0 1.3 1.1 0.9
Supplements: Zinc 1.4 1.5 1.7 -1.1 -1.3
Medication: Co-codamol 2.0 2.4 4.6 -0.4 -2.1
Medication: Metformin 4.5 6.3 9.9 -3.2 -1.7
Diabetes (father) 1.6 2.0 3.2 -1.8 -0.9
Diabetes (mother) 0.2 0.3 0.5 0.7 -0.3
Severe depression (siblings) 0.2 0.2 0.4 -0.6 -0.0
Pack years adult smoking proportion 0.4 0.6 1.2 1.1 -0.1
Impedance of leg (right) 3.3 15.8 29.7 -5.5 1.4
Leg fat-free mass (left) 1.3 6.6 13.1 3.6 -0.4
Trunk fat percentage 0.8 3.3 6.6 -2.6 0.1
Hand grip strength (right) 0.9 2.4 4.6 2.1 -0.5
Townsend deprivation index at recruitment 0.2 0.3 0.4 -0.7 -0.3
Current tobacco smoking 1.9 3.1 6.1 2.5 0.2
Average weekly fortified wine intake 0.8 1.0 1.6 0.6 -1.3
Maternal smoking around birth 0.5 0.7 1.1 0.7 1.0
Fed-up feelings 0.3 0.6 1.1 -1.1 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.0 -1.0 -0.1
Relative age voice broke 2.4 3.6 5.9 -2.4 -1.2
Taking other prescription medications 0.8 1.2 1.5 -0.9 -1.2
Age when periods started (menarche) 0.1 0.2 0.3 -0.5 0.2
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.4 -0.6 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 2.3 1.5 1.5
Tinnitus: Yes, but not now, but have in the past 4.8 5.2 10.0 -0.6 -3.2
Qualifications: CSEs or equivalent 1.6 2.1 2.5 1.3 -1.6
Serious illness, injury or assault to yourself 0.3 0.3 0.4 0.5 -0.6
High blood pressure 0.2 0.6 1.1 -0.2 -1.0
Hayfever, allergic rhinitis or eczema 0.8 1.7 2.7 -1.6 -0.9
Multivitamins +/- minerals 0.5 0.6 1.2 -0.2 -1.1
Stomach or abdominal pain in last month 0.4 0.5 0.9 1.0 -0.1
Supplements: Glucosamine 0.3 0.3 0.6 -0.3 -0.8
Diverticular disease/diverticulitis (self-reported) 1.9 2.2 3.9 0.7 -2.0
Medication: Atenolol 1.5 1.9 3.2 1.8 -0.8
Medication: Levothyroxine sodium 0.3 0.5 1.0 -1.0 0.1
Sitting height 1.7 11.7 21.6 4.6 1.4
Chronic bronchitis/emphysema (father) 0.8 0.9 1.7 -0.5 -1.3
High blood pressure (mother) 1.4 2.0 4.0 0.1 -2.0
Body mass index (BMI) 0.4 1.8 2.1 1.2 -1.5
Impedance of leg (left) 2.5 12.0 21.3 -4.6 1.7
Leg predicted mass (left) 1.2 6.5 12.8 3.6 -0.4
Trunk fat mass 0.1 0.2 0.5 -0.7 -0.1
Waist circumference 0.1 0.2 0.3 0.5 -0.3
Number of incorrect matches in round 1.3 2.2 3.0 -1.7 1.2
Past tobacco smoking 0.7 1.2 1.7 -0.8 -1.3
Alcohol usually taken with meals 1.0 1.6 1.7 -1.3 -1.3
Nervous feelings 0.4 0.8 1.4 -1.2 -0.4
Frequency of tenseness / restlessness in last 2 weeks 2.9 4.5 8.0 -2.8 0.9
Hearing difficulty/problems with background noise 0.6 1.0 1.3 -0.8 -1.1
Hair/balding pattern: Pattern 2 0.2 0.3 0.5 -0.2 0.7
Had menopause 3.7 4.7 9.2 -3.0 -0.4
Had other major operations 0.7 0.9 1.3 1.2 -0.7
Forced vital capacity (FVC) 1.5 5.9 8.8 3.0 1.7
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.3 3.8 2.0 1.6
Ever unenthusiastic/disinterested for a whole week 0.0 0.0 0.0 0.2 0.0
Qualifications: None of the above 0.4 0.9 1.3 -1.1 -0.6
Financial difficulties in last 2 years 1.4 1.8 2.9 -0.9 -1.7
Mouth/teeth dental problems 1.8 2.8 5.5 2.4 0.4
Heart attack 0.5 0.6 0.8 -0.9 0.6
Allergy 2.4 5.6 11.2 3.3 -0.1
Pain all over the body in last month 1.2 1.2 1.4 -1.2 -1.1
Diabetes (self-reported) 2.8 4.4 6.2 -2.5 -1.6
Hayfever/allergic rhinitis (self-reported) 2.0 2.6 5.2 -0.2 -2.3
Medication: Ramipril 2.1 2.8 4.5 -2.1 1.0
Medication: Simvastatin 0.8 1.1 1.9 -1.4 0.6
Fluid intelligence score 1.2 2.6 3.3 -1.8 1.4
Illnesses of siblings 0.3 0.4 0.7 -0.1 0.9
Neuroticism score 0.6 1.2 2.3 -1.5 -0.3
Weight 0.5 2.5 4.7 2.2 -0.6
Impedance of arm (right) 3.8 17.8 31.0 -5.6 2.1
Arm fat percentage (right) 0.2 0.7 1.1 -1.1 -0.5
Trunk fat-free mass 3.0 17.2 34.0 5.8 -0.7
Hip circumference 0.1 0.3 0.4 0.7 -0.3
Time employed in main current job 0.5 0.5 0.6 -0.8 -0.7
Alcohol intake versus 10 years previously 0.4 0.6 1.0 -0.5 1.0
Father’s age at death 1.3 1.7 2.3 -1.1 -1.5
Worrier / anxious feelings 0.2 0.3 0.6 -0.8 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 1.6 0.4 -1.3
Falls in the last year 0.5 0.6 0.8 -0.6 0.9
Hair/balding pattern: Pattern 3 0.2 0.3 0.4 0.5 -0.6
Number of live births 0.2 0.3 0.4 -0.4 -0.6
Forced expiratory volume in 1-second (FEV1) 1.4 4.8 8.7 3.0 0.9
Pulse rate 1.0 1.7 3.0 1.7 -0.6
Happiness 1.2 1.4 2.6 0.5 -1.6
Noisy workplace 0.2 0.3 0.5 -0.7 0.2
Qualifications: A levels/AS levels or equivalent 2.5 5.4 9.0 3.0 1.4
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.6 3.0 -1.7 -0.3
Mouth/teeth dental problems: Dentures 0.7 1.3 2.2 -1.5 0.6
Asthma 1.2 2.3 4.5 -2.1 -0.4
Medication: Ibuprofen (e.g. Nurofen) 4.4 5.6 8.9 3.0 -1.5
Medication: Cholesterol lowering 1.1 1.7 2.8 -1.7 0.7
Depression (self-reported) 0.2 0.2 0.4 -0.6 -0.1
Medication: Lansoprazole 4.6 5.2 8.4 -2.9 -1.4
Prospective memory result 2.3 2.8 4.9 2.2 -0.8
Lung cancer (father) 0.0 0.0 0.0 -0.0 -0.1
Illnesses of mother 0.6 0.8 1.5 0.3 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.7 5.3 8.2 2.9 1.5
Pulse wave Arterial Stiffness index 1.4 1.6 1.6 1.2 -1.3
Impedance of arm (left) 4.2 19.2 33.8 -5.8 2.2
Arm fat mass (right) 0.2 0.6 0.7 0.9 -0.7
Trunk predicted mass 3.0 17.1 33.8 5.8 -0.7
Standing height 0.5 5.2 7.4 2.7 1.7
Length of working week for main job 3.5 3.8 5.0 -2.2 1.6
Exposure to tobacco smoke at home 0.6 0.7 1.4 -1.2 -0.2
Breastfed as a baby 0.6 0.7 0.7 -0.8 0.9
Tense / ‘highly strung’ 0.6 0.9 1.5 -1.2 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.2 -0.5 0.4
Hair/balding pattern: Pattern 4 1.7 4.0 4.2 -2.1 2.0
Birth weight of first child 0.3 0.6 0.8 -0.9 -0.6
Peak expiratory flow (PEF) 1.5 3.4 5.6 2.4 1.1
Pulse wave reflection index 0.2 0.2 0.3 0.6 -0.3
Ever highly irritable/argumentative for 2 days 0.1 0.2 0.3 -0.2 -0.5
Loud music exposure frequency 0.9 1.0 1.6 -0.6 -1.2
Qualifications: O levels/GCSEs or equivalent 3.2 5.1 7.6 2.8 1.6
Mouth/teeth dental problems: Bleeding gums 1.6 2.1 3.5 -1.9 -0.8
Blood clot in the leg (DVT) 0.2 0.2 0.3 -0.6 -0.3
Medication: Paracetamol 0.6 0.9 1.8 0.3 -1.3
Headache pain in last month 0.8 1.4 2.7 1.6 0.2
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 1.5 1.2 -0.2
Glaucoma (self-reported) 0.2 0.2 0.2 0.4 0.5
Gout (self-reported) 2.2 3.0 6.0 -0.2 -2.5
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.7 -0.8 0.3
Medication: Amlodipine 0.1 0.2 0.3 0.1 -0.6
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.6 -0.5 -0.8
Birth weight 0.5 1.1 2.0 1.4 -0.4
Chronic bronchitis/emphysema (mother) 1.8 2.1 2.2 -1.5 -1.4
High blood pressure (siblings) 0.3 0.4 0.8 0.1 -0.9
Forced vital capacity (FVC), Best measure 1.6 6.0 7.0 2.6 2.2
Body fat percentage 0.7 2.9 5.7 -2.4 -0.2
Leg fat percentage (right) 0.9 3.2 5.5 -2.3 -1.0
Arm fat-free mass (right) 2.3 11.6 22.1 4.7 -1.1
Exposure to tobacco smoke outside home 0.4 0.5 0.9 -0.9 -0.4
Comparative body size at age 10 0.1 0.2 0.3 0.3 0.5
Number of full brothers 1.1 1.3 1.7 1.3 1.0
Worry too long after embarrassment 1.7 2.8 4.7 -2.2 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.4 0.4 -1.2
Wheeze or whistling in the chest in last year 0.3 0.5 0.9 0.2 -0.9
Number of children fathered 0.0 0.0 0.1 -0.0 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.7 1.8 1.3 -1.4
Age at first live birth 0.2 0.4 0.8 0.9 -0.2
Pulse wave peak to peak time 1.7 2.0 2.5 -1.2 1.6
Health satisfaction 0.2 0.3 0.3 -0.6 -0.5
Shortness of breath walking on level ground 0.1 0.1 0.2 0.3 -0.4
Qualifications: College or University degree 0.1 0.4 0.7 -0.4 0.8
Eye problems/disorders: None of the above 0.6 0.7 0.8 -0.8 0.9
Mouth/teeth dental problems: Loose teeth 1.7 2.0 3.9 -2.0 0.3
Emphysema/chronic bronchitis 3.3 3.7 4.5 -1.7 2.1
Medication for pain relief, constipation, heartburn 1.5 2.6 3.1 -1.4 1.8
Neck or shoulder pain in last month 0.1 0.1 0.3 0.5 -0.0
Medication: Blood pressure 0.1 0.2 0.4 -0.6 0.1
Angina (self-reported) 0.3 0.4 0.7 0.9 0.3
Migraine (self-reported) 5.5 6.8 12.9 3.6 0.8
Medication: Ibuprofen 3.6 4.3 7.6 2.8 -1.0
Medication: Allopurinol 2.1 2.8 5.2 0.7 -2.3
Medication: Omeprazole 0.1 0.1 0.1 -0.1 0.3
Medication: Seretide 50 evohaler 0.0 0.0 0.1 -0.3 0.1
Mean time to correctly identify matches 1.7 3.3 4.4 -2.1 -1.4
Heart disease (mother) 1.2 1.5 2.9 0.1 -1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.1 1.5 -0.9 -1.2
Whole body fat mass 0.0 0.2 0.2 -0.3 -0.5
Leg fat mass (right) 0.1 0.3 0.6 -0.1 -0.7
Arm predicted mass (right) 2.3 11.6 22.2 4.7 -1.0
Pulse rate, automated reading 0.8 2.7 5.2 0.5 -2.3
Alcohol intake frequency. 1.1 2.6 3.3 1.8 1.4
Comparative height size at age 10 0.6 3.3 5.5 2.4 1.0
Number of full sisters 1.3 1.6 3.2 -0.1 -1.8
Suffer from ‘nerves’ 0.9 1.4 2.8 -1.7 -0.2
Overall health rating 0.7 1.4 1.9 -1.4 -1.0
Chest pain or discomfort 0.3 0.4 0.8 0.3 0.9
Had major operations 1.1 1.3 1.8 -1.4 -0.9
Age at last live birth 0.5 0.8 1.6 -0.2 -1.2
Family relationship satisfaction 0.5 0.6 1.2 -1.1 -0.2
Leg pain on walking 2.4 3.1 4.5 2.1 -1.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.0 0.2 1.0
Commuting to job workplace: Car/motor vehicle 1.1 1.2 1.9 1.4 -0.7
Illness, injury, bereavement, stress in last 2 years 1.0 1.3 2.5 -0.1 1.6
Medication: Aspirin 0.1 0.1 0.2 -0.3 -0.4
Supplements: Vitamin C 0.4 0.5 0.9 -0.9 -0.4
Knee pain experienced in last month 0.2 0.3 0.7 -0.1 -0.8
Hypertension (Self-reported) 0.2 0.5 0.9 -0.4 -0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 2.5 -1.6 0.7
Illnesses of father: Heart disease 0.2 0.2 0.4 -0.2 -0.6
Illnesses of siblings: Diabetes 1.1 1.4 2.2 -1.5 -0.8
Smoking status: Previous 0.3 0.5 1.0 -0.2 1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 0.6 0.7 -0.2
Whole body fat-free mass 2.4 13.6 26.8 5.2 -0.6
Leg fat-free mass (right) 1.8 9.4 18.6 4.3 -0.4
Arm fat percentage (left) 0.3 1.1 1.9 -1.4 -0.6
Average weekly red wine intake 1.1 1.6 3.1 -1.8 0.3
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.5 -0.5 0.7
Mood swings 0.5 1.0 1.4 -0.8 1.2
Loneliness, isolation 1.6 2.1 4.2 -0.4 2.0
Long-standing illness, disability or infirmity 0.5 0.8 1.5 0.1 -1.2
Ever had bowel cancer screening 3.4 4.0 5.2 -1.7 2.3
Diabetes diagnosed by doctor 2.9 4.8 6.0 -2.4 -1.9
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.1 0.1 -0.4
Friendships satisfaction 1.3 1.7 1.9 -1.2 -1.4
Qualifications: nursing, teaching 1.2 1.9 3.2 1.8 -0.7
Commuting to job workplace: Walk 1.3 1.4 2.9 -1.7 0.1
Eye problems/disorders: Cataract 0.8 0.9 1.5 1.2 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.4 0.1 -1.2
Medication for cholesterol 0.2 0.4 0.7 -0.8 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.0 -1.0 -0.2
Back pain experienced in last month 4.4 6.5 9.9 1.7 -3.1
Mineral and other dietary supplements 0.3 0.4 0.5 0.6 -0.7
Breast cancer (self-reported) 0.5 0.6 1.2 1.1 -0.0
Asthma (self-reported) 1.1 2.2 4.1 -2.0 -0.5
Osteoporosis (self-reported) 0.5 0.6 0.7 -0.8 -0.7
Osteoarthritis (self-reported) 0.4 0.5 1.0 1.0 0.1
Medication: Aspirin 0.2 0.3 0.4 -0.5 -0.6
Medication: Gliclazide 1.1 1.3 2.4 -1.6 0.4
Illnesses of father: None of the above (group 1) 0.3 0.3 0.6 -0.7 0.3
Smoking status: Current 1.8 2.8 5.6 2.4 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.4 1.2 0.3
Whole body water mass 2.4 13.7 26.9 5.2 -0.7
Leg predicted mass (right) 1.7 9.3 18.6 4.3 -0.3
Arm fat mass (left) 0.2 0.7 0.9 0.9 -0.7
Number of self-reported non-cancer illnesses 0.4 0.8 1.4 0.3 -1.2
Average weekly champagne plus white wine intake 2.4 3.3 4.1 -2.0 1.6
Miserableness 1.0 1.7 2.3 1.0 1.5
Guilty feelings 0.8 1.1 1.7 -1.3 0.8
Wears glasses or contact lenses 0.8 0.9 1.7 -1.3 -0.4
Ever taken oral contraceptive pill 0.5 0.6 0.7 -0.8 0.7
Hearing aid user 1.4 1.5 2.9 0.4 1.7
Mother’s age at death 0.3 0.4 0.8 -0.9 0.2
Financial situation satisfaction 1.3 1.6 1.8 -1.2 1.4
Tinnitus: Yes, now most or all of the time 3.7 4.3 8.0 0.8 2.8
Commuting to job workplace: Public transport 0.6 0.7 1.1 -0.6 1.0
Eye problems/disorders: Glaucoma 0.0 0.0 0.1 0.3 0.2
Medication: Blood pressure 0.1 0.1 0.2 -0.1 -0.5
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.4 1.2 0.6
Supplements: Fish oil (including cod liver oil) 0.7 0.9 1.8 0.2 1.3
High cholesterol (Self-reported) 0.2 0.3 0.4 -0.6 0.6
Medication: Bendroflumethiazide 0.2 0.2 0.3 -0.4 -0.6
Medication: Paracetamol 0.8 1.2 2.4 0.1 -1.5
Medication: Lisinopril 0.2 0.2 0.4 -0.2 -0.6
Medication: Atorvastatin 0.8 1.0 1.6 -0.7 1.3
Illnesses of father: High blood pressure 1.4 1.7 3.4 1.8 -0.3
Alcohol drinker status: Never 0.4 0.4 0.8 0.9 0.2
Ever smoked 0.4 0.8 1.3 1.2 0.5
Basal metabolic rate 1.9 10.4 20.5 4.5 -0.6
Leg fat percentage (left) 0.5 1.8 2.8 -1.7 -0.9
Arm fat-free mass (left) 2.4 12.2 23.8 4.9 -0.8
Number of operations (self-reported) 0.5 0.8 1.6 -1.3 0.1
Average weekly beer plus cider intake 1.3 1.8 3.3 0.6 -1.8
Irritability 0.3 0.5 0.8 -0.9 -0.5
Risk taking 0.2 0.3 0.5 -0.4 -0.7
Ever had prostate specific antigen (PSA) test 3.7 4.3 4.9 1.9 -2.2
Fractured/broken bones in last 5 years 0.2 0.3 0.5 -0.7 -0.3
Age started oral contraceptive pill 1.5 1.9 3.5 -0.5 -1.9
Diastolic blood pressure, automated reading 1.9 6.0 6.1 2.5 -2.4
Ever depressed for a whole week 1.3 1.6 3.0 -0.4 1.7
Unable to work because of sickness or disability 0.7 0.9 1.8 -1.3 0.1
Commuting to job workplace: Cycle 2.3 2.8 5.1 -2.3 0.7
Myopia 1.6 2.4 3.5 -1.9 -1.1
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.0 0.3 1.0
Cholesterol lowering medication 0.3 0.4 0.8 -0.3 0.9
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.0 -1.0 0.1
Pain experienced in last month 0.9 1.5 2.7 -0.7 1.6
Supplements: Calcium 1.7 1.8 1.9 -1.3 -1.4
Basal cell carcinoma (self-reported) 1.5 1.8 3.3 -1.8 0.5
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.8 -0.9 0.5
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.7 -0.8 0.3
Heart disease (siblings) 0.2 0.2 0.3 -0.6 -0.4
Alcohol drinker status: Previous 0.2 0.2 0.4 0.7 0.0
Pack years of smoking 0.4 0.5 1.1 1.0 0.1
Impedance of whole body 4.1 21.1 37.9 -6.2 2.1
Leg fat mass (left) 0.1 0.2 0.4 0.2 -0.6
Arm predicted mass (left) 2.7 13.6 26.3 5.1 -1.0