TWAS hub - PNKP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1480	0.0310	1.0e-13	0.155	0.143	0.159	0.155	0.145	2.1e-18	4.6e-17	7.0e-19	1.9e-18	2.8e-17
2	GTEx	Adipose Subcutaneous	0.2110	0.0510	1.4e-04	0.150	NA	0.158	NA	0.155	2.5e-12	NA	6.4e-13	NA	1.1e-12
3	GTEx	Artery Tibial	0.1649	0.0551	4.9e-03	0.153	NA	0.127	NA	0.147	4.5e-12	NA	4.0e-10	NA	1.4e-11
4	GTEx	Brain Cerebellum	0.3890	0.0940	1.4e-04	0.209	NA	0.172	NA	0.200	8.0e-07	NA	8.5e-06	NA	1.5e-06
5	GTEx	Lung	0.1795	0.0629	5.8e-03	0.155	NA	0.147	NA	0.145	6.7e-12	NA	2.2e-11	NA	3.1e-11
6	GTEx	Nerve Tibial	0.1777	0.0599	1.2e-03	0.154	NA	0.146	NA	0.157	5.2e-11	NA	1.5e-10	NA	3.0e-11
7	GTEx	Spleen	0.5150	0.1030	1.2e-04	0.243	NA	0.254	NA	0.229	6.3e-07	NA	3.4e-07	NA	1.5e-06
8	GTEx	Whole Blood	0.1410	0.0400	1.4e-05	0.096	NA	0.125	NA	0.114	3.8e-09	NA	1.5e-11	NA	1.2e-10
9	YFS	Blood	0.2208	0.0265	0.0e+00	0.280	0.284	0.303	0.245	0.297	2.8e-92	8.6e-94	3.9e-101	2.5e-79	7.8e-99
10	TCGA	Breast Invasive Carcinoma	0.0303	0.0140	2.2e-04	0.002	0.018	0.008	NA	0.006	8.6e-02	8.7e-05	8.4e-03	NA	1.7e-02
11	TCGA	Colon Adenocarcinoma	0.1260	0.0740	6.6e-03	0.005	0.019	0.009	NA	0.002	1.5e-01	2.8e-02	9.3e-02	NA	2.2e-01
12	TCGA	Kidney Renal Clear Cell Carcinoma	0.0983	0.0558	2.8e-03	0.008	0.016	0.009	NA	0.002	4.2e-02	5.0e-03	2.6e-02	NA	1.7e-01
13	TCGA	Lung Adenocarcinoma	0.0302	0.0184	7.7e-03	0.001	0.017	0.008	NA	0.008	2.3e-01	4.0e-03	3.2e-02	NA	3.6e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Migraine (self-reported)	5.4	6.7	16.2	-3.8	-0.7	-0.9	-1.3	-1.3	-0.3	-3.2	-3.8	-3.2	-3.5	-1.0	-1.9	-4.0
Had other major operations	4.2	5.2	9.0	-1.9	-2.0	-2.1	-1.8	-2.3	-1.6	-2.4	-2.4	-2.0	-3.0	-2.6	-2.3	-2.7
Basal cell carcinoma (self-reported)	4.1	4.9	14.1	2.3	1.1	1.8	1.4	1.8	1.1	2.3	2.5	2.7	2.6	1.8	3.8	2.3
Number of full brothers	3.3	4.1	10.1	-2.0	-2.2	-1.7	-1.8	-1.9	-1.1	-3.2	-2.4	-1.9	-1.8	-1.9	-1.7	-2.0
Medication: Ramipril	3.2	4.2	8.3	2.3	1.9	1.0	0.8	1.6	0.4	2.4	2.1	2.5	2.6	1.4	2.9	2.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.2	3.8	6.7	0.8	2.5	1.8	2.0	2.1	2.0	1.1	1.9	1.7	2.0	2.3	2.6	1.7
Medication: Atenolol	3.1	3.9	9.5	-1.5	3.1	2.7	3.0	2.7	3.0	0.0	-0.1	-1.1	-0.6	1.5	1.2	-1.1
Medication: Allopurinol	2.9	3.9	6.5	-1.4	-2.2	-2.3	-2.3	-2.5	-1.6	-1.3	-1.8	-1.5	-2.1	-1.4	-2.5	-1.9
Myopia	2.8	4.0	9.7	2.5	0.8	1.4	1.6	1.7	1.0	2.4	2.3	2.1	3.1	-0.7	1.6	3.0
Supplements: Calcium	2.7	3.0	6.2	1.7	1.2	1.4	1.9	1.8	1.4	1.7	1.9	1.7	2.2	0.2	2.5	1.9
Forced vital capacity (FVC), Best measure	2.6	9.6	18.2	-3.0	-2.7	-2.4	-2.6	-3.1	-2.1	-3.5	-4.3	-3.5	-2.6	-3.2	-3.7	-2.9
Hearing aid user	2.6	2.9	5.4	-0.9	-2.1	-1.9	-1.7	-2.2	-2.0	-0.8	-1.7	-1.4	-1.6	-1.5	-2.3	-1.3
Had menopause	2.5	3.2	8.8	2.8	0.3	0.6	0.2	0.7	0.0	1.4	2.8	3.0	1.9	0.5	1.8	2.5
Trunk fat-free mass	2.5	14.4	35.6	-6.0	-0.4	-0.0	1.2	-0.5	1.5	-5.1	-5.7	-5.4	-4.1	-3.6	-0.7	-5.4
Trunk predicted mass	2.5	14.5	35.8	-6.0	-0.5	-0.1	1.1	-0.6	1.5	-5.1	-5.7	-5.4	-4.2	-3.7	-0.8	-5.4
Qualifications: O levels/GCSEs or equivalent	2.5	3.9	11.4	-2.3	-1.2	-0.9	-1.1	-1.1	-1.1	-2.1	-3.4	-2.5	-2.6	-1.5	-0.4	-2.9
Depression (Nagel 2018)	2.4	3.6	9.7	0.1	2.3	2.1	2.5	2.4	2.0	1.9	1.3	0.7	0.7	3.1	2.1	0.5
Medication: Metformin	2.4	3.4	9.1	3.0	0.4	-0.1	-0.1	0.4	-0.6	1.9	2.6	3.0	1.8	2.0	1.6	2.3
Tinnitus: Yes, but not now, but have in the past	2.4	2.6	8.0	0.2	-1.6	-2.3	-2.0	-2.2	-2.8	-0.1	-1.2	-0.3	-1.9	-0.2	-1.5	-1.2
Impedance of arm (left)	2.4	11.0	27.1	5.2	-1.2	-1.9	-2.8	-1.5	-3.1	3.5	3.8	4.7	3.8	1.3	-0.8	5.0
Wears glasses or contact lenses	2.4	2.8	6.4	1.8	1.5	1.3	1.0	1.3	0.8	2.5	1.9	1.9	1.7	1.6	2.0	1.6
Medication: Atorvastatin	2.4	3.0	8.6	0.2	1.7	1.6	1.9	2.0	2.1	-0.4	1.3	1.0	2.5	0.3	2.9	1.9
Impedance of whole body	2.4	12.4	30.6	5.4	-0.7	-1.6	-2.5	-1.1	-2.8	4.0	4.3	5.1	4.2	1.8	-1.2	5.5
Medication: Lansoprazole	2.3	2.7	9.1	3.0	-0.6	-1.0	-1.3	-0.5	-1.7	2.6	2.2	2.2	0.6	0.3	-0.0	1.6
Arm predicted mass (left)	2.3	11.5	29.6	-5.4	-0.4	0.2	1.3	-0.2	1.5	-4.6	-4.8	-4.7	-4.0	-3.1	-0.3	-4.9
Impedance of leg (right)	2.2	10.6	27.1	4.8	-0.3	-0.9	-1.3	-0.5	-1.7	3.9	4.2	4.9	4.1	2.5	-0.8	5.2
Maternal smoking around birth	2.2	3.2	5.9	-1.0	-2.4	-2.1	-2.1	-2.4	-1.8	-1.4	-1.9	-1.6	-1.5	-0.6	-2.1	-1.4
Whole body water mass	2.2	12.4	29.4	-5.4	-0.7	-0.2	0.9	-0.7	1.1	-4.8	-5.2	-5.0	-4.0	-3.7	-0.6	-5.0
Ulcerative Colitis (UC)	2.1	4.0	6.4	-1.1	-2.5	-2.3	-2.5	-2.5	-2.5	-1.1	-2.0	-1.9	-2.0	-1.6	-1.3	-1.9
Primary Biliary Cirrhosis	2.1	2.9	4.9	-0.8	-2.0	-2.2	-1.7	-2.2	-1.9	-1.3	-1.7	-1.4	-2.0	0.3	-1.8	-1.8
Impedance of arm (right)	2.1	9.6	23.1	4.8	-0.7	-1.6	-2.4	-1.1	-2.6	3.4	3.7	4.6	3.6	1.8	-0.7	4.8
Medication: Cholesterol lowering	2.1	3.3	7.6	1.7	1.2	1.3	1.2	1.8	1.1	1.9	1.9	1.8	2.7	1.3	1.9	2.8
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.8	14.6	-3.1	-1.9	-1.6	-1.7	-2.3	-1.3	-2.9	-3.8	-3.3	-2.6	-2.5	-2.6	-3.1
Whole body fat-free mass	2.1	12.2	29.2	-5.4	-0.6	-0.2	1.0	-0.6	1.1	-4.8	-5.2	-4.9	-3.9	-3.7	-0.6	-4.9
Arm fat-free mass (left)	2.1	10.5	26.7	-5.2	-0.3	0.2	1.3	-0.2	1.3	-4.3	-4.6	-4.5	-3.8	-3.3	-0.5	-4.6
Relative age voice broke	2.0	3.1	9.1	3.0	-0.2	-0.2	-0.1	0.2	-0.9	1.8	2.1	2.5	2.5	1.3	-0.0	2.9
Qualifications: A levels/AS levels or equivalent	2.0	4.5	12.4	-2.8	-0.7	-0.2	-0.6	-0.6	-0.1	-2.3	-3.5	-2.7	-3.0	-2.1	-1.9	-2.7
Leg pain on walking	2.0	2.5	7.1	-1.8	0.1	-0.9	-0.9	-1.0	-0.3	-1.2	-2.6	-1.7	-2.6	-1.0	-0.7	-2.7
Neuroticism (Nagel 2018)	1.9	4.4	11.8	1.9	1.4	1.3	1.2	1.7	0.6	3.4	2.2	2.2	2.4	2.6	2.1	2.7
Worry (Nagel 2018)	1.9	3.9	8.4	2.1	1.4	1.2	1.1	1.7	0.7	2.9	2.4	2.6	2.0	1.9	1.8	2.7
Sitting height	1.9	13.4	35.3	-5.6	-1.0	-1.0	-0.4	-1.5	0.2	-4.4	-5.9	-5.3	-3.9	-3.9	-2.1	-4.5
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	6.4	2.3	-0.1	0.5	0.3	0.4	-0.1	1.3	2.0	2.0	2.5	-0.2	-0.1	2.5
Arm fat-free mass (right)	1.9	9.6	24.0	-4.9	-0.4	0.2	1.2	-0.2	1.3	-4.2	-4.4	-4.3	-3.5	-3.3	-0.3	-4.4
Medication: Ibuprofen	1.9	2.3	6.9	-2.5	0.3	0.5	0.3	0.1	1.0	-0.7	-2.4	-2.1	-1.6	1.2	0.3	-2.6
Arm predicted mass (right)	1.9	9.8	23.9	-4.9	-0.6	0.2	1.2	-0.2	1.3	-4.1	-4.5	-4.3	-3.5	-3.5	-0.5	-4.4
Bipolar Disorder (2018)	1.8	2.8	5.7	-0.7	-1.8	-2.2	-1.7	-2.4	-2.0	-0.8	-1.6	-1.2	-2.1	0.1	-1.4	-2.0
Age at First Birth	1.8	2.7	7.0	2.5	1.0	0.2	0.6	0.5	-0.4	2.4	2.3	2.6	1.6	1.0	-0.2	2.3
LDL Cholesterol	1.8	2.8	5.6	-1.0	-2.0	-2.3	-2.1	-2.3	-1.9	-2.4	-1.6	-0.6	-1.1	-0.8	-0.7	-1.3
Forced expiratory volume in 1-second (FEV1)	1.8	6.0	12.5	-2.9	-1.6	-1.3	-1.5	-2.1	-1.1	-2.8	-3.5	-2.9	-2.4	-2.7	-3.0	-2.8
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	6.6	-2.4	0.4	0.8	0.5	0.3	1.2	-0.7	-2.3	-2.1	-1.4	1.4	0.3	-2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	5.0	1.3	1.1	0.7	0.8	1.1	0.6	1.9	1.6	1.5	2.2	1.2	1.6	2.1
Leg fat-free mass (right)	1.8	9.5	20.5	-4.5	-0.8	-0.4	0.5	-0.8	0.4	-4.1	-4.5	-4.3	-3.6	-3.6	-0.5	-4.3
Leg predicted mass (right)	1.8	9.3	20.5	-4.5	-0.8	-0.4	0.6	-0.7	0.5	-4.0	-4.5	-4.3	-3.6	-3.6	-0.5	-4.3
Illnesses of father: High blood pressure	1.8	2.3	8.7	-2.3	-0.1	-0.6	-0.3	-0.5	0.3	-2.9	-1.9	-1.8	-1.4	-1.5	-1.0	-1.7
Basal metabolic rate	1.8	9.9	23.1	-4.8	-0.7	-0.2	1.0	-0.6	0.8	-4.3	-4.6	-4.3	-3.7	-3.4	-0.3	-4.5
Alzheimer’s Disease (in mother)	1.7	2.0	7.9	-0.1	-1.8	-1.0	-1.4	-1.1	-1.2	-1.6	-1.1	-0.7	0.1	-2.8	-2.3	0.0
Type 2 Diabetes (T2D) (2012)	1.7	2.0	7.2	1.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	2.7	1.7	2.3	2.1	2.0
Forced vital capacity (FVC)	1.7	6.7	15.0	-3.1	-1.5	-1.4	-1.6	-2.1	-1.1	-2.8	-3.9	-3.0	-2.2	-3.0	-3.4	-2.6
Suffer from ‘nerves’	1.7	2.6	6.4	1.9	1.4	1.0	0.6	1.3	0.6	1.6	2.1	1.7	2.4	0.6	1.6	2.5
Irritability	1.7	2.8	10.9	1.1	1.4	1.1	0.6	1.4	0.6	2.0	1.8	1.6	1.4	3.3	2.3	1.3
Alzheimer’s Disease (including proxy)	1.6	2.4	9.8	0.3	-1.8	-1.2	-1.4	-1.2	-1.5	-1.0	-0.4	-0.4	0.7	-3.1	-3.0	0.6
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	8.9	1.8	0.3	0.4	0.2	0.7	-0.2	3.0	1.7	1.3	0.7	1.7	0.0	1.2
Impedance of leg (left)	1.6	7.6	19.1	3.9	-0.4	-1.0	-1.7	-0.7	-1.8	3.5	3.5	3.9	3.4	1.8	-1.4	4.4
Time employed in main current job	1.6	1.9	4.5	1.6	1.2	1.4	1.1	1.6	1.2	0.9	1.3	0.7	2.1	-0.3	1.3	2.0
Pulse wave reflection index	1.6	2.0	5.6	-1.2	1.9	1.5	1.8	1.6	2.2	-1.0	0.2	-0.1	1.0	0.9	2.4	0.1
Neuroticism	1.5	3.5	8.2	2.4	0.7	0.6	0.3	1.1	-0.4	2.9	2.5	2.6	1.7	2.6	0.9	2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.1	5.3	1.2	1.6	0.9	1.5	1.6	0.6	1.1	1.3	0.9	1.8	2.3	1.5	1.6
Multivitamins +/- minerals	1.5	1.9	3.5	0.8	0.9	1.5	1.9	1.7	1.3	1.2	1.5	0.7	1.8	0.7	1.7	1.2
Asthma	1.5	2.9	5.3	1.3	2.0	1.0	1.4	1.2	1.0	1.5	2.3	2.3	1.9	0.9	2.3	2.0
Schizophrenia vs Biploar Disorder	1.4	1.8	4.5	0.1	0.0	-2.0	-2.0	-1.9	-1.9	0.0	-1.1	-1.1	-0.5	-2.1	-0.8	-0.6
Vitamin and mineral supplements	1.4	1.9	4.5	-1.5	-0.1	-1.0	-1.0	-1.2	-0.7	-1.5	-1.9	-1.7	-2.1	-0.7	-1.2	-1.9
Hand grip strength (right)	1.4	3.7	7.0	-2.4	-1.6	-1.3	-0.7	-2.0	-0.6	-2.6	-2.1	-1.9	-2.0	-1.7	-2.1	-2.6
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	5.4	2.0	0.5	-0.2	-0.1	0.2	-0.5	2.2	2.3	2.1	1.1	1.8	0.8	1.9
Mouth/teeth dental problems: Dentures	1.4	2.4	11.1	1.6	0.6	0.8	0.3	1.2	0.4	2.4	1.6	1.4	0.7	3.3	1.7	0.9
Exposure to tobacco smoke at home	1.4	1.5	4.0	1.1	-1.8	-1.7	-1.6	-1.6	-2.0	-0.6	0.1	0.4	-0.5	0.9	-1.4	0.0
Pulse wave peak to peak time	1.4	1.6	7.5	1.4	-1.7	-1.2	-1.4	-1.3	-1.6	0.1	0.2	0.5	-0.2	-0.8	-2.7	0.6
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	4.0	-0.7	-1.7	-1.7	-1.6	-1.7	-1.5	-0.1	-0.9	-1.2	-0.7	-2.0	0.2	-1.1
Mineral and other dietary supplements	1.4	1.8	4.0	-1.1	-0.7	-1.8	-1.9	-1.6	-1.3	-2.0	-1.2	-1.1	-0.8	-1.3	-1.0	-1.0
Commuting to job workplace: Cycle	1.4	1.7	4.4	2.1	-0.0	0.2	-0.1	0.4	-0.1	0.8	1.8	2.0	1.8	0.7	1.2	2.0
Frequency of depressed mood in last 2 weeks	1.3	1.8	3.9	0.0	1.7	1.4	2.0	1.7	1.4	1.0	1.1	1.0	0.4	1.9	1.6	0.5
Leg fat-free mass (left)	1.3	7.1	15.8	-3.8	-0.8	-0.4	0.6	-0.7	0.4	-3.7	-4.0	-3.6	-3.0	-3.2	-0.2	-3.7
Supplements: Glucosamine	1.3	1.7	3.1	1.1	1.0	1.6	1.5	1.7	0.9	1.8	1.3	0.7	0.8	1.5	1.0	1.2
Leg predicted mass (left)	1.3	6.9	15.6	-3.8	-0.8	-0.4	0.6	-0.7	0.3	-3.6	-4.0	-3.5	-3.0	-3.2	-0.2	-3.6
Mouth/teeth dental problems	1.3	1.9	5.3	-2.3	-0.0	0.0	0.4	-0.1	0.7	-2.2	-2.1	-2.3	-0.5	-1.9	0.2	-1.1
Allergy	1.3	3.0	7.5	-2.2	-1.2	-0.2	-0.3	-0.6	-0.3	-1.7	-2.3	-2.7	-2.3	-1.4	-1.5	-2.7
Diabetes (self-reported)	1.3	2.0	5.9	2.4	0.4	-0.2	0.2	0.3	-0.6	1.1	2.4	2.3	1.4	1.1	0.8	1.9
Prospective memory result	1.3	1.6	3.3	-1.6	1.4	1.5	1.5	1.3	1.8	-0.4	-0.8	-1.5	-0.6	0.4	1.0	-1.3
Pulse wave Arterial Stiffness index	1.3	1.5	6.7	-1.4	1.5	1.2	1.4	1.2	1.6	-0.3	-0.3	-0.7	0.2	0.6	2.6	-0.6
Heart disease (mother)	1.3	1.6	3.5	0.1	1.4	1.7	1.9	1.7	1.7	1.0	0.8	0.9	-0.3	1.3	1.6	-0.3
Mother’s age at death	1.3	1.7	6.6	0.8	-1.4	-1.5	-1.7	-1.6	-1.9	0.1	0.4	0.5	-0.7	-0.6	-2.6	-0.1
Supplements: Fish oil (including cod liver oil)	1.3	1.6	3.6	-0.0	1.3	1.8	1.8	1.7	1.9	1.4	0.6	0.3	0.8	1.9	0.4	0.6
Medication: Co-codamol	1.2	1.4	5.6	0.9	1.1	0.6	0.6	0.8	0.1	2.4	1.2	1.0	0.5	1.1	2.4	0.1
Peak expiratory flow (PEF)	1.2	2.9	6.7	-2.0	-0.6	-0.5	-0.1	-1.0	-0.2	-2.6	-2.6	-2.2	-1.4	-2.4	-1.6	-1.9
Qualifications: nursing, teaching	1.2	1.9	7.0	-1.6	-0.5	0.1	-0.0	-0.1	-0.1	-1.3	-1.9	-1.4	-2.1	-2.6	-0.1	-1.7
Asthma (self-reported)	1.2	2.4	4.7	1.3	1.8	0.8	1.1	1.0	0.8	1.4	2.2	2.2	1.7	1.1	2.0	1.8
Heart attack/myocardial infarction (self-reported)	1.2	1.5	3.6	0.4	1.7	0.7	0.9	0.9	1.1	0.6	1.1	1.5	1.7	1.0	1.9	1.5
Prostate Cancer	1.1	1.6	4.2	0.6	-2.0	-1.9	-1.1	-1.8	-1.8	-1.3	-1.3	-0.1	-0.3	-1.1	-0.5	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	7.5	-1.9	-1.0	-0.5	-0.8	-0.8	-0.3	-1.2	-2.3	-2.2	-2.7	-0.3	-1.0	-2.5
Heart attack	1.1	1.4	2.9	0.5	1.6	0.6	0.7	0.8	0.9	0.6	1.1	1.5	1.7	1.2	1.7	1.5
Length of working week for main job	1.1	1.2	2.9	1.6	-1.0	-1.7	-1.0	-1.4	-1.6	-0.2	0.7	0.8	0.8	-0.9	-0.1	1.0
Hair/balding pattern: Pattern 4	1.1	2.6	9.7	2.3	0.2	0.4	0.6	0.6	-0.0	0.6	1.8	1.8	3.1	0.0	1.6	3.0
Loud music exposure frequency	1.1	1.2	3.5	0.4	-1.9	-1.4	-1.3	-1.4	-1.9	0.8	-0.4	-0.2	-0.6	-0.4	-1.1	-0.2
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	4.0	2.0	-0.0	-0.3	-0.3	-0.1	-0.7	1.1	1.5	1.9	1.7	0.7	-0.7	1.9
Family relationship satisfaction	1.1	1.4	2.3	0.8	0.8	1.0	1.4	1.1	1.2	1.2	1.1	1.5	1.2	0.8	1.5	1.2
Commuting to job workplace: Walk	1.1	1.2	2.9	1.4	-0.5	0.2	0.3	0.2	0.2	1.3	1.4	1.6	1.5	0.6	1.1	1.7
Respiratory disease	1.0	2.2	5.6	1.6	1.5	0.4	0.6	0.6	0.3	1.5	2.2	2.4	1.8	0.8	1.7	1.9
Diabetes (father)	1.0	1.3	3.8	1.0	-0.5	-1.2	-1.0	-0.9	-1.8	2.0	0.8	1.5	0.7	0.6	0.2	1.1
Current tobacco smoking	1.0	1.6	4.1	-2.0	0.9	0.5	0.2	0.3	1.3	-1.8	-1.7	-1.8	-0.6	0.5	0.3	-1.8
Medication: Levothyroxine sodium	1.0	1.7	4.8	1.6	0.9	0.8	0.6	0.9	0.5	2.1	1.8	1.0	0.6	2.2	1.4	0.4
Fluid intelligence score	1.0	2.1	4.2	1.6	0.5	1.4	1.6	1.4	0.6	2.0	2.0	2.0	0.9	1.2	0.4	1.7
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	3.3	-1.3	-1.0	-0.8	-0.8	-1.2	-0.8	-1.3	-1.5	-1.4	-1.8	-0.6	-1.6	-1.8
Health satisfaction	1.0	1.3	4.5	0.4	1.2	1.1	0.8	1.3	1.0	1.7	0.5	0.8	0.8	1.5	2.1	0.6
Mouth/teeth dental problems: Loose teeth	1.0	1.1	2.5	1.4	-1.3	-1.0	-1.5	-0.9	-1.6	1.1	1.0	1.4	-0.5	0.4	-0.3	0.3
Diabetes diagnosed by doctor	1.0	1.6	5.0	2.2	0.2	-0.6	-0.3	-0.0	-0.8	1.0	1.8	2.2	1.2	0.9	1.2	1.5
Smoking status: Current	1.0	1.6	4.1	-2.0	0.7	0.2	-0.1	-0.0	1.0	-1.9	-1.9	-2.0	-0.8	0.4	0.1	-1.8
Average weekly champagne plus white wine intake	1.0	1.3	3.7	1.6	-0.3	-0.6	-0.6	-0.5	-0.7	1.0	1.3	1.7	1.8	-0.6	0.7	1.9
Alcohol drinker status: Previous	1.0	1.2	4.5	-0.4	1.2	0.7	0.9	1.0	1.3	0.1	-0.4	-0.9	0.6	1.9	2.1	-0.3
Ovarian Cancer	0.9	1.2	2.8	-0.4	-1.0	-0.9	-0.9	-1.1	-0.8	-1.0	-1.1	-1.6	-1.0	-1.0	-1.7	-1.1
Neuroticism (2016)	0.9	1.3	4.7	0.8	1.0	0.7	0.9	0.9	0.8	0.7	1.3	1.1	2.2	0.8	-0.3	2.0
Allergy or Eczema	0.9	2.4	6.5	2.5	0.1	0.2	0.2	0.5	0.1	2.4	1.5	2.3	2.1	0.9	0.5	2.5
Relative age of first facial hair	0.9	1.8	6.6	2.2	0.0	0.1	-0.4	0.5	-0.5	0.7	1.7	1.3	2.3	0.3	-0.7	2.6
Diabetes (mother)	0.9	1.1	1.7	-0.9	-1.1	-0.9	-1.0	-1.2	-0.8	-1.0	-1.3	-0.7	-1.3	-1.2	-0.7	-1.3
Fed-up feelings	0.9	1.6	6.0	1.2	1.2	0.7	0.5	0.7	0.3	1.3	1.5	1.1	1.7	2.4	0.9	1.4
Medication: Simvastatin	0.9	1.4	4.1	1.4	0.3	0.5	0.3	0.9	0.3	1.9	1.0	1.2	1.2	1.0	2.0	1.4
Number of live births	0.9	1.3	2.7	-0.0	-1.3	-1.6	-1.5	-1.3	-1.4	-1.3	-0.6	-0.3	-0.7	-1.6	-1.1	-0.5
Standing height	0.9	8.7	21.4	-3.5	-1.9	-1.8	-1.2	-2.3	-1.0	-3.7	-4.6	-3.5	-2.2	-4.3	-2.9	-2.6
Birth weight of first child	0.9	1.7	4.5	0.1	-1.7	-1.9	-1.8	-2.0	-2.1	-0.1	0.4	0.3	-1.2	0.5	-1.2	-0.8
Headache pain in last month	0.9	1.6	3.7	-1.9	1.5	1.1	1.6	0.8	1.7	0.5	-1.2	-0.6	-1.0	1.0	0.9	-1.6
Worry too long after embarrassment	0.9	1.6	6.2	1.4	0.7	0.2	0.2	0.5	-0.3	2.5	1.6	1.8	0.8	1.6	0.7	1.4
Supplements: Vitamin C	0.9	1.0	2.9	1.0	-1.7	-0.7	-1.3	-0.7	-1.0	-0.0	0.6	1.2	0.7	0.0	-1.6	1.0
Illnesses of siblings: Diabetes	0.9	1.1	2.8	1.7	0.1	0.6	0.3	0.6	0.2	1.5	1.4	1.5	0.9	1.2	0.7	1.2
Ever had bowel cancer screening	0.9	1.0	3.8	1.9	-1.4	-0.4	-0.8	-0.3	-0.9	1.0	1.0	1.0	0.6	-0.9	0.4	1.2
Breast cancer (self-reported)	0.9	1.1	4.0	-1.0	-0.4	-0.6	-0.5	-0.5	-0.3	-1.0	-1.2	-0.6	-1.8	0.5	1.2	-2.0
Osteoarthritis (self-reported)	0.9	1.2	3.5	-0.4	1.2	1.5	1.4	1.5	1.7	0.2	0.2	-0.6	0.2	0.5	1.9	-0.4
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.7	-1.6	0.2	1.0	0.4	0.7	1.2	-0.5	-1.2	-1.3	-0.8	0.2	0.8	-1.5
Verbal and Numeric Reasoning (VNR)	0.8	1.8	4.4	1.5	0.5	1.4	1.7	1.2	0.6	1.5	1.7	2.1	0.6	1.5	0.6	1.4
Hand grip strength (left)	0.8	2.1	7.9	-1.5	-1.2	-1.1	-0.5	-1.6	-0.6	-2.8	-1.3	-1.4	-0.9	-1.6	-1.5	-1.5
Average weekly spirits intake	0.8	1.0	3.1	0.8	-1.0	-1.5	-1.7	-1.4	-1.7	-0.1	0.0	0.4	-0.7	-0.2	-0.8	-0.3
Sensitivity / hurt feelings	0.8	1.3	4.2	0.9	1.2	0.6	0.5	0.9	0.3	2.0	1.2	1.2	1.6	0.4	0.8	1.7
Ever had hysterectomy (womb removed)	0.8	0.9	2.1	0.6	-1.1	-1.4	-1.3	-1.3	-1.4	-0.8	0.0	0.7	0.5	-0.6	0.9	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	6.5	-1.6	-0.7	-0.5	-0.9	-0.7	-0.3	-0.9	-1.8	-1.7	-2.5	0.4	-1.0	-2.3
High blood pressure (mother)	0.8	1.2	2.2	-1.1	-1.0	-1.5	-0.9	-1.4	-1.4	0.1	-1.2	-0.8	-1.4	-0.3	-0.5	-1.3
Neuroticism score	0.8	1.7	4.2	1.3	1.1	0.6	0.1	0.9	0.0	1.9	1.5	1.6	1.3	2.1	1.2	1.6
Chronic bronchitis/emphysema (mother)	0.8	1.0	4.7	1.0	0.3	-0.4	-0.7	-0.3	-0.6	1.1	1.2	1.7	-0.3	2.2	0.4	0.2
Leg fat percentage (right)	0.8	2.7	6.4	2.1	0.3	0.5	1.2	0.9	0.0	1.8	2.4	2.5	1.2	1.7	2.4	1.8
Medication: Omeprazole	0.8	1.0	2.6	-0.1	-1.4	-1.3	-1.2	-1.3	-1.4	-0.4	-0.7	-0.6	-0.6	-1.6	-0.7	-0.5
Alcohol intake frequency.	0.8	1.8	6.5	-1.9	0.5	0.2	0.4	0.1	0.9	-1.2	-2.0	-2.5	-1.3	-0.4	0.5	-2.1
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.3	-0.3	-1.5	-1.1	-1.3	-1.2	-1.2	-0.7	-1.2	-0.9	-0.4	-1.1	-0.1	-0.4
Average weekly red wine intake	0.8	1.2	2.8	1.6	-1.0	-0.5	-0.8	-0.9	-1.1	1.2	1.4	1.7	1.0	-0.5	-0.3	1.5
Back pain experienced in last month	0.8	1.1	3.6	-1.5	0.7	0.2	0.2	0.1	0.2	0.3	-1.3	-1.9	-1.5	-0.9	0.3	-1.8
Bipolar Disorder or Schizophrenia	0.7	1.7	3.5	-1.1	-0.9	-1.7	-1.2	-1.8	-1.4	-0.8	-1.1	-1.4	-1.6	0.1	-0.9	-1.9
Rheumatoid Arthritis	0.7	1.0	4.5	1.0	-2.1	-0.9	-0.3	-0.8	-1.1	0.5	0.2	0.0	0.3	-0.9	-1.8	0.6
Hearing difficulty/problems: Yes	0.7	1.1	2.7	-1.5	-0.2	0.1	-0.4	-0.2	0.3	-1.7	-1.2	-1.1	-1.5	-1.3	-0.4	-1.4
Systolic blood pressure, automated reading	0.7	2.2	4.7	-1.4	1.6	1.6	1.9	2.2	1.7	-0.3	0.3	-1.0	-0.8	1.8	2.0	-0.7
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.6	0.1	-1.6	-1.1	-1.2	-1.2	-1.1	-1.2	-0.3	0.3	-0.4	-0.8	0.1	-0.5
Nervous feelings	0.7	1.3	4.2	1.0	1.1	0.7	0.4	1.0	0.6	0.9	1.0	1.4	1.2	2.0	1.1	1.6
Pulse rate	0.7	1.1	3.1	-1.6	0.5	0.4	0.5	0.4	0.6	-0.5	-1.3	-1.4	-1.8	0.1	0.9	-1.8
Depression (self-reported)	0.7	0.9	2.7	0.8	-0.6	-0.3	-0.8	-0.3	-0.8	1.5	0.2	0.3	-1.6	1.5	-1.0	-0.6
Mean time to correctly identify matches	0.7	1.4	4.4	2.1	0.8	-0.0	0.1	0.4	-0.3	1.5	1.5	1.7	1.2	0.6	1.2	1.5
Had major operations	0.7	0.8	2.4	0.9	0.6	0.4	0.4	0.5	0.4	0.7	1.5	1.4	0.9	1.0	0.6	1.1
Age at last live birth	0.7	1.1	2.9	0.7	1.1	0.9	1.0	0.8	0.6	1.0	1.0	1.4	1.1	1.7	0.2	1.2
Osteoporosis (self-reported)	0.7	0.9	2.7	0.5	-0.8	-1.4	-1.7	-1.4	-1.3	-0.4	-0.1	0.5	0.5	-1.1	-0.9	0.3
Guilty feelings	0.7	1.1	2.4	1.0	-0.1	0.4	0.3	0.6	-0.1	1.5	1.3	1.5	1.0	1.6	-0.5	1.5
Commuting to job workplace: Public transport	0.7	0.9	2.6	0.8	-1.6	-0.5	-0.8	-0.8	-1.3	0.6	-0.3	0.0	-0.7	-1.6	-1.3	0.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.0	0.7	-1.1	-1.2	-1.4	-1.2	-1.4	0.3	0.3	0.3	0.0	-1.2	-0.6	0.4
Depressed Affect (Nagel 2018)	0.6	1.3	3.5	0.7	0.9	0.9	0.7	0.9	0.4	1.9	0.9	0.7	1.5	1.9	1.2	1.3
Body Mass Index (BMI) (2010)	0.6	0.8	4.0	-0.4	0.5	1.0	1.2	1.0	1.2	-0.4	0.4	-0.3	-0.6	0.7	2.0	-0.8
Ulcerative Colitis	0.6	0.9	2.4	0.5	-1.4	-1.6	-1.5	-1.4	-1.5	0.0	-0.1	0.2	-0.3	-0.2	-0.2	0.0
Cardiovascular Disease	0.6	2.0	6.0	-1.4	2.5	1.4	1.5	1.8	1.9	-0.5	0.2	-0.3	0.9	0.9	2.0	0.5
Number of treatments/medications taken	0.6	1.1	3.4	-0.2	1.5	1.0	0.8	1.1	1.1	1.8	0.2	0.1	-0.1	1.3	1.9	-0.2
Angina	0.6	0.8	2.0	-1.4	0.8	0.1	0.3	0.2	0.7	-0.6	-1.1	-1.3	-1.3	0.7	-0.3	-1.2
Supplements: Zinc	0.6	0.6	2.2	1.0	0.4	0.3	0.6	0.2	-0.1	1.5	0.9	1.1	0.2	1.1	0.9	0.5
Number of incorrect matches in round	0.6	0.9	2.1	1.5	-0.9	-1.0	-0.8	-0.7	-1.3	-0.4	1.1	0.7	0.7	-1.4	-0.4	0.9
Alcohol usually taken with meals	0.6	1.0	2.7	1.4	-1.5	-1.3	-1.1	-1.1	-1.6	0.1	0.3	1.1	-0.1	-0.9	-0.6	0.6
Pain all over the body in last month	0.6	0.6	1.8	1.1	-0.3	-1.2	-1.3	-0.8	-1.1	-0.3	0.7	0.7	-0.0	0.8	0.4	-0.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.9	2.3	-0.2	-0.5	-1.3	-1.1	-1.3	-1.0	-0.2	-0.9	-0.5	-1.5	-0.4	-0.9	-0.9
Weight	0.6	3.1	6.6	-2.5	-0.7	-0.2	1.0	-0.3	0.3	-2.5	-2.4	-2.1	-2.3	-1.8	0.8	-2.6
Emphysema/chronic bronchitis	0.6	0.7	2.2	1.1	0.6	-0.1	0.2	0.1	-0.0	0.7	1.0	1.4	1.5	0.0	0.8	1.3
Medication for pain relief, constipation, heartburn	0.6	1.1	3.3	1.3	-0.5	-0.7	-0.3	-0.6	-1.4	0.3	1.0	0.9	1.3	-0.4	-1.3	1.8
Angina (self-reported)	0.6	0.8	1.9	-1.4	1.0	0.4	0.6	0.5	0.9	-0.3	-1.0	-1.2	-1.2	0.9	-0.2	-1.1
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.6	-1.1	1.4	0.5	0.6	0.7	0.7	-0.5	-1.1	-1.6	-0.7	-0.4	0.3	-1.0
High cholesterol (Self-reported)	0.6	1.1	2.3	0.4	1.3	0.9	0.6	1.2	0.9	0.4	0.7	1.1	1.5	1.0	1.5	1.4
Fractured/broken bones in last 5 years	0.6	0.8	2.8	1.5	-0.6	-0.2	-0.3	-0.4	-0.6	-0.1	1.1	0.8	0.8	-1.7	-1.3	0.9
Age started oral contraceptive pill	0.6	0.8	3.1	0.4	0.7	0.8	0.8	1.0	1.0	-0.4	0.5	1.3	0.3	-0.7	1.8	0.5
Diastolic blood pressure, automated reading	0.6	1.9	7.5	-2.7	0.4	0.6	1.1	0.7	1.0	-0.9	-1.4	-2.2	-1.6	-0.0	0.1	-1.9
Unable to work because of sickness or disability	0.6	0.7	2.1	1.2	0.3	-0.9	-1.4	-0.8	-1.4	1.1	0.3	0.6	0.6	0.1	0.4	0.6
Pain experienced in last month	0.6	1.0	4.6	0.9	-0.9	0.2	0.1	0.3	0.3	-0.7	0.7	1.1	2.1	-0.4	-0.0	2.0
Irritable Bowel Disease (IBD)	0.5	1.1	2.5	-0.9	-1.3	-1.0	-1.6	-1.3	-1.3	0.8	-1.0	-0.9	-1.2	-0.4	-0.6	-1.0
Breast Cancer	0.5	1.2	3.2	1.6	0.5	0.8	0.7	0.8	0.7	1.1	1.8	1.4	1.2	0.7	0.7	1.3
Height	0.5	9.1	29.3	-4.0	-1.3	-1.4	-0.8	-1.9	-0.1	-4.2	-5.4	-3.9	-2.9	-2.7	-1.9	-3.7
Systolic Blood Pressure	0.5	2.6	9.2	-3.0	1.7	1.0	1.0	1.3	1.4	-1.6	-1.4	-2.2	-1.6	0.9	0.2	-1.8
Hypothyroidism (self reported)	0.5	1.2	3.6	1.9	-1.3	-1.1	-1.4	-1.0	-1.2	1.1	1.0	0.5	0.4	1.3	-0.2	0.2
Chronotype (morning person)	0.5	1.2	4.1	0.6	-0.9	-1.6	-1.6	-1.6	-2.0	0.4	0.1	0.2	-1.4	0.2	-0.3	-1.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.8	-0.9	1.7	0.8	0.3	0.5	1.3	0.1	-0.6	-0.2	0.4	0.4	1.1	-0.5
Pack years adult smoking proportion	0.5	0.7	2.6	-1.6	1.0	-0.3	-0.3	-0.0	0.4	-1.0	-0.8	-1.2	-0.7	0.8	0.5	-1.1
Chronic bronchitis/emphysema (father)	0.5	0.6	2.3	1.1	-1.5	-0.8	-1.2	-0.8	-1.0	-0.5	0.1	0.3	-0.3	0.4	-0.2	-0.1
Hair/balding pattern: Pattern 2	0.5	0.6	2.1	0.1	-1.2	-0.9	-0.8	-0.8	-0.9	-0.4	-0.3	0.3	-0.8	-0.0	-1.4	-0.3
Father’s age at death	0.5	0.7	1.8	1.1	-0.7	-0.8	-0.7	-0.5	-0.9	0.5	0.3	0.8	0.7	1.4	1.0	0.9
Falls in the last year	0.5	0.7	3.5	0.9	0.3	0.1	0.5	0.4	0.1	0.7	0.2	0.3	1.7	0.1	1.9	1.1
Noisy workplace	0.5	0.6	1.6	0.6	-0.5	-1.1	-1.2	-1.3	-1.0	-0.6	-0.2	0.1	-0.6	0.8	-0.5	-0.8
Birth weight	0.5	1.1	4.1	-1.1	-0.5	-0.1	0.2	-0.4	-0.2	-0.6	-1.3	-1.4	-2.0	-1.0	-0.5	-1.9
Body fat percentage	0.5	1.8	5.3	1.9	-0.2	-0.0	0.5	0.4	-0.5	1.3	2.2	2.3	0.8	1.1	1.7	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.5	-1.2	-0.2	0.2	-0.6	-0.1	0.4	-0.7	-0.9	-1.1	-0.8	-0.1	-1.0	-1.0
Medication: Seretide 50 evohaler	0.5	0.6	2.6	0.6	0.5	0.2	0.4	0.3	0.0	1.0	0.5	0.4	1.6	-0.5	0.1	1.4
Comparative height size at age 10	0.5	2.8	7.3	-2.7	1.0	1.0	1.4	0.7	1.9	-2.3	-2.7	-1.8	-0.3	-1.4	0.9	-1.4
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.6	-1.0	0.5	0.4	0.2	0.4	0.3	-0.6	-0.4	-0.3	-1.5	0.5	0.7	-1.6
Knee pain experienced in last month	0.5	0.8	3.3	0.1	1.0	0.8	0.8	1.0	1.0	1.0	0.7	0.3	0.2	1.8	1.4	-0.1
Illnesses of father: Heart disease	0.5	0.7	1.5	0.1	1.0	0.9	1.1	1.2	1.0	-0.5	0.6	1.0	0.6	0.7	0.7	0.6
Long-standing illness, disability or infirmity	0.5	0.8	3.1	0.3	1.0	1.1	0.5	0.9	0.5	1.7	-0.1	0.2	-0.1	1.8	0.8	-0.1
Eye problems/disorders: Cataract	0.5	0.6	2.0	-0.8	-0.6	-0.1	-0.2	-0.4	-0.4	-0.6	-1.4	-1.0	-1.1	-0.8	-0.5	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	3.6	-0.0	-0.9	-0.6	-0.5	-1.0	-0.7	-0.3	-0.5	-0.1	-1.3	-1.4	-1.9	-0.9
Medication for cholesterol	0.5	0.8	3.3	1.3	-1.0	-0.6	-0.6	-0.7	-1.0	0.4	0.8	1.1	-0.0	-0.1	-1.8	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.6	1.0	-0.2	-0.4	-1.2	-0.4	-0.8	0.6	1.3	1.1	0.4	0.5	0.7	0.3
Medication: Gliclazide	0.5	0.5	1.4	1.0	-1.0	-0.8	-1.2	-0.7	-1.0	-0.1	0.7	0.7	-0.1	0.8	0.0	0.2
Illnesses of father: None of the above (group 1)	0.5	0.7	1.7	0.8	-1.0	-1.1	-1.0	-1.1	-1.3	1.2	0.2	0.4	0.2	-0.2	0.3	0.2
Financial situation satisfaction	0.5	0.7	2.1	0.7	-1.2	-1.2	-0.7	-1.0	-1.4	-0.4	0.0	0.3	-0.5	-0.9	-0.6	-0.0
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.0	-1.0	-0.8	-0.6	-0.9	-0.8	-0.4	-0.9	-1.0	-0.6	-0.4	-0.7	-0.8	-0.8
Medication: Paracetamol	0.5	0.8	2.2	0.2	0.5	0.8	0.8	0.9	1.2	1.4	0.5	0.3	-0.9	1.0	1.5	-0.9
Ever depressed for a whole week	0.5	0.6	1.7	0.2	-1.2	-0.8	-1.3	-0.8	-0.8	0.6	-0.3	-0.2	-1.0	-0.4	-0.7	-0.5
Pack years of smoking	0.5	0.7	2.0	-1.4	1.4	0.2	0.0	0.4	0.8	-0.8	-0.4	-1.0	-0.6	1.1	0.8	-0.9
Alzheimer’s Disease (in father)	0.4	0.4	1.9	0.3	-0.4	-0.6	-0.1	-0.5	-0.5	-0.1	0.4	0.1	0.7	-1.4	-1.1	0.3
Reaction Time	0.4	0.7	2.3	0.9	1.5	0.7	0.7	0.9	0.6	0.7	0.8	0.8	0.5	0.7	1.2	0.7
BMI	0.4	2.1	6.8	-1.6	0.3	0.5	1.6	0.6	0.8	-1.7	-1.1	-1.4	-1.8	-0.5	2.6	-2.1
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.7	1.3	-0.3	-1.0	-1.1	-0.5	-1.2	-1.0	0.8	1.2	0.0	0.4	0.1	0.5
Trunk fat percentage	0.4	1.5	4.8	1.9	-0.6	-0.5	-0.0	-0.0	-1.0	1.0	2.0	2.2	0.5	0.8	1.2	1.5
Qualifications: CSEs or equivalent	0.4	0.5	1.5	-1.2	0.7	0.1	-0.0	0.3	0.4	-1.1	-0.9	-1.0	0.4	-0.6	0.5	-0.3
Serious illness, injury or assault to yourself	0.4	0.5	2.5	-0.3	0.3	0.3	0.4	0.3	0.7	0.7	-0.2	-0.0	-0.5	1.0	1.6	-1.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.6	-0.5	0.6	0.3	0.7	0.6	0.6	-1.1	-0.3	-0.5	-0.1	-0.3	1.3	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.5	-0.9	1.2	0.4	0.5	0.4	0.4	0.1	-1.1	-0.5	-0.8	1.0	0.9	-0.9
Medication: Paracetamol	0.4	0.7	1.5	0.2	0.7	0.9	1.0	0.9	1.2	0.6	0.5	0.2	-1.0	1.1	0.8	-0.9
Gout (self-reported)	0.4	0.6	1.9	-0.5	-1.0	-1.0	-0.8	-1.0	-0.5	-0.1	-0.4	-0.2	-1.4	0.1	-0.8	-1.1
Medication: Amlodipine	0.4	0.6	2.2	0.4	-1.4	-0.9	-1.5	-0.8	-0.8	-1.0	-0.3	-0.3	-0.2	-0.2	0.2	-0.5
Comparative body size at age 10	0.4	1.1	4.9	0.1	0.8	1.2	1.1	1.2	0.7	0.5	-0.3	0.4	0.2	1.9	2.2	-0.0
Eye problems/disorders: None of the above	0.4	0.5	2.7	0.1	-1.1	-0.7	-0.1	-0.6	-0.2	-0.5	0.1	0.1	0.9	-1.6	-0.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	3.3	-1.8	0.0	-0.7	-0.2	-0.9	0.0	-1.3	-1.5	-0.7	-0.4	-0.2	-0.2	-0.8
Friendships satisfaction	0.4	0.5	1.2	0.7	-1.1	-1.0	-0.7	-0.8	-0.8	0.0	0.2	0.8	0.5	-0.4	0.8	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.1	-1.2	-0.4	-0.2	-1.0	-0.6	-0.6	-0.5	-1.4	-0.9	-1.3	-0.1	-1.0	-1.4
Leg fat percentage (left)	0.4	1.6	4.1	1.4	0.3	0.5	1.0	0.8	0.0	1.5	1.9	1.8	0.6	1.4	2.0	1.2
Vascular/heart problems diagnosed by doctor	0.4	1.0	5.3	0.3	-1.7	-0.4	-0.7	-1.1	-0.8	-0.3	-0.7	-0.1	-0.5	-1.2	-2.3	-0.5
HbA1C	0.3	0.3	2.4	0.3	0.0	-0.5	-0.7	-0.4	-0.4	-1.6	-0.1	-0.5	0.0	0.1	-0.5	-0.2
HDL Cholesterol	0.3	0.4	2.0	0.9	-0.2	-0.2	-0.2	-0.2	-0.3	0.1	0.6	-0.1	0.4	-1.4	-1.0	0.8
Triglycerides	0.3	0.5	1.4	-1.2	-0.4	-0.8	-0.5	-0.6	-0.3	-1.2	-1.0	0.2	-0.9	0.3	0.3	-0.9
Blood Eosinophil Count	0.3	2.3	5.1	0.8	1.3	1.7	2.3	2.0	1.2	1.6	1.6	1.7	0.9	1.5	0.9	1.5
Blood Red Count	0.3	3.2	15.5	1.3	-1.2	-0.7	-0.2	-0.3	-0.5	-0.0	-0.6	2.5	3.9	-1.6	0.3	3.6
Heel T-Score	0.3	2.7	6.6	0.2	2.2	2.5	2.2	2.6	2.2	0.8	0.7	0.4	-0.6	1.7	1.6	0.0
Smoking Status	0.3	0.8	2.8	-1.6	0.6	-0.0	-0.2	-0.2	0.5	-0.9	-1.3	-1.7	-0.2	0.2	0.7	-1.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.1	1.0	0.1	0.2	-0.3	0.3	-0.1	0.4	0.9	1.1	0.8	-0.7	0.8	0.9
Medication for hormone replacement therapy	0.3	0.4	1.3	-1.1	0.5	-0.2	-0.4	-0.3	0.0	-0.7	-0.9	-0.8	-0.2	0.1	-0.1	-0.9
Townsend deprivation index at recruitment	0.3	0.4	1.8	0.4	0.1	0.5	0.7	0.7	0.6	0.6	0.5	0.0	1.3	0.0	0.1	1.2
Taking other prescription medications	0.3	0.5	1.2	0.3	-0.4	-0.8	-0.9	-0.8	-0.7	1.0	0.3	-0.1	-1.1	0.6	-0.2	-0.7
High blood pressure	0.3	0.7	4.5	-0.3	1.3	0.3	0.6	1.0	0.6	-0.1	0.5	-0.1	0.2	0.9	2.1	0.2
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.9	1.4	-0.7	-0.7	-0.7	-0.4	-0.7	0.4	0.3	0.9	0.9	0.2	-0.7	1.3
Stomach or abdominal pain in last month	0.3	0.4	1.4	-0.7	1.0	0.7	0.6	0.7	0.5	0.4	-0.5	-0.6	0.1	-1.2	-0.2	-0.2
Body mass index (BMI)	0.3	1.3	5.0	-1.2	0.1	0.5	1.5	0.7	0.8	-1.2	-0.5	-0.9	-1.5	0.0	2.2	-1.6
Qualifications: None of the above	0.3	0.6	3.3	0.7	0.4	-0.0	0.3	0.2	0.2	0.8	1.4	0.9	0.5	1.8	-0.3	0.7
Worrier / anxious feelings	0.3	0.5	2.4	0.7	0.6	0.1	-0.2	0.2	-0.4	1.5	0.4	1.1	0.3	1.3	0.2	0.7
Hair/balding pattern: Pattern 3	0.3	0.5	1.5	-1.1	0.1	0.5	-0.3	0.2	0.6	-0.6	-0.8	-0.7	-1.2	0.2	-0.0	-1.2
Tense / ‘highly strung’	0.3	0.5	1.4	1.1	-0.5	-0.5	-0.6	-0.4	-0.7	1.2	0.7	0.8	-0.3	1.0	0.1	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.9	0.9	0.6	0.6	0.1	0.6	0.2	1.1	0.9	0.9	0.1	1.4	0.2	0.4
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.6	0.2	0.7	0.7	0.5	0.8	0.7	1.3	0.2	0.1	0.4	0.4	0.6	0.5
Blood clot in the leg (DVT)	0.3	0.4	1.4	-0.6	0.8	0.8	0.8	0.8	1.2	0.4	0.3	0.5	-0.4	-0.1	0.9	-0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	2.0	1.4	-0.3	-0.3	-0.3	-0.1	-0.3	1.1	1.0	0.3	0.3	1.4	0.2	0.0
Age at first live birth	0.3	0.5	1.4	-0.1	0.8	1.0	0.9	0.9	1.0	0.1	0.2	0.1	0.2	1.2	-0.2	0.3
Shortness of breath walking on level ground	0.3	0.4	1.6	-0.2	1.0	0.2	0.7	0.2	0.3	0.3	-0.4	-0.1	-0.6	1.3	0.7	-0.7
Neck or shoulder pain in last month	0.3	0.4	1.4	-1.1	0.2	0.0	-0.2	-0.1	0.3	-0.4	-0.6	-0.7	-1.2	-0.5	-0.7	-1.0
Number of full sisters	0.3	0.4	2.2	-0.0	0.2	0.3	0.1	0.1	0.4	0.6	0.1	-0.0	1.5	-0.8	0.7	0.8
Overall health rating	0.3	0.7	1.7	1.1	0.0	-0.9	-1.2	-0.4	-1.3	0.9	0.1	0.6	-0.2	1.1	0.8	-0.1
Chest pain or discomfort	0.3	0.4	2.2	-1.0	0.3	-0.2	-0.5	-0.3	0.1	-1.5	-0.4	-0.3	-0.7	-0.3	-0.1	-0.8
Hypertension (Self-reported)	0.3	0.9	5.5	-0.1	1.3	0.4	0.8	1.1	0.7	0.3	0.7	0.1	0.3	1.0	2.3	0.4
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.5	0.4	-0.4	-0.1	0.3	0.1	-0.0	0.8	0.6	0.1	0.7	-1.2	-0.2	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.4	0.6	0.1	0.1	-0.2	-0.1	-0.3	-0.7	0.1	0.5	1.2	-0.8	0.2	0.6
Medication: Aspirin	0.3	0.4	0.7	0.4	0.5	0.7	0.1	0.8	0.6	0.8	0.5	0.5	0.7	0.3	0.8	0.7
Number of self-reported non-cancer illnesses	0.3	0.6	2.1	-0.7	1.4	0.4	0.2	0.6	1.0	-0.3	-0.3	-0.5	-0.4	0.5	1.5	-0.7
Medication: Blood pressure	0.3	0.7	5.2	-0.0	0.9	0.6	0.4	0.9	0.6	0.2	0.0	-0.1	0.5	0.7	2.3	0.2
Medication: Lisinopril	0.3	0.4	1.1	-0.4	0.3	0.7	1.0	0.8	0.8	0.7	0.7	0.4	0.3	0.5	0.7	0.4
Alcohol drinker status: Never	0.3	0.3	1.1	-1.1	0.2	0.4	0.3	0.2	0.7	0.0	-0.8	-0.9	-0.5	-0.1	-0.5	-0.6
Number of operations (self-reported)	0.3	0.5	1.0	0.7	-0.9	-1.0	-1.0	-0.9	-0.8	-0.0	0.4	0.6	0.4	-1.0	-0.0	0.3
Average weekly beer plus cider intake	0.3	0.4	1.6	-0.6	0.9	0.5	0.7	0.5	0.4	-0.7	-0.2	-0.2	-0.1	1.3	0.4	-0.5
Cholesterol lowering medication	0.3	0.4	4.2	-0.3	0.6	0.1	0.4	0.4	0.5	0.0	-0.1	0.3	0.0	-0.3	2.1	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.0	-0.4	0.6	0.7	0.9	0.7	1.0	0.7	0.4	0.5	-0.4	-0.5	0.9	-0.0
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.9	0.4	0.2	1.1	1.1	0.9	0.4	1.4	0.5	0.8	-0.2	0.3	-0.7	0.7
Mean Putamen Volume	0.2	0.3	1.3	-0.0	0.3	0.2	-0.0	0.2	0.2	0.2	0.2	0.6	0.9	1.1	0.9	0.3
Fasting Glucose	0.2	0.3	1.6	-0.3	-0.6	0.2	-0.2	-0.1	0.3	-0.5	-0.3	-0.2	1.0	-1.3	-0.2	0.2
Lung FEV1/FVC ratio	0.2	0.8	4.2	-0.1	0.2	0.7	0.2	0.4	0.6	-0.3	0.2	-0.4	-0.4	2.0	2.0	-1.1
Lung FVC	0.2	1.0	2.1	-1.4	-0.8	-0.7	-1.2	-0.9	-0.5	-0.7	-1.4	-1.2	-1.0	-0.0	-1.1	-1.2
Severe depression (siblings)	0.2	0.2	0.6	0.6	0.4	0.2	-0.1	0.2	0.1	0.1	0.4	0.3	0.7	-0.7	0.3	0.8
Average weekly fortified wine intake	0.2	0.3	1.0	-1.0	0.5	-0.0	0.5	0.2	0.6	0.4	-0.5	-0.2	-0.3	-0.3	0.8	-0.6
Age when periods started (menarche)	0.2	0.4	1.8	0.4	-0.1	-0.0	-0.6	-0.3	-0.1	-0.6	1.1	0.3	0.4	1.4	-1.0	0.2
Waist circumference	0.2	0.8	2.8	-0.9	0.4	0.4	1.4	0.8	0.7	-1.2	-0.3	-0.4	-0.7	-0.6	1.7	-0.6
Past tobacco smoking	0.2	0.3	0.9	0.8	-0.1	-0.5	-0.7	-0.2	-0.3	-0.7	0.7	0.9	0.3	-0.2	-0.5	0.4
Hearing difficulty/problems with background noise	0.2	0.3	0.8	0.6	0.5	0.0	-0.6	-0.1	-0.2	0.7	0.7	0.9	0.2	0.6	0.2	0.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.9	-0.6	0.3	-0.2	-0.5	-0.1	-0.2	0.9	-0.2	-0.1	-0.6	0.8	-0.6	-0.4
Financial difficulties in last 2 years	0.2	0.3	0.7	0.5	0.7	-0.3	0.0	0.2	-0.4	0.3	0.7	0.7	-0.8	0.8	-0.0	-0.2
Arm fat percentage (right)	0.2	0.7	4.1	0.8	-0.1	0.1	0.8	0.4	-0.1	0.2	1.2	1.0	-0.0	0.7	2.0	0.4
Hip circumference	0.2	0.8	2.2	-1.1	-0.2	-0.1	1.1	0.1	0.2	-1.1	-0.8	-0.8	-1.3	-0.4	1.5	-1.3
Happiness	0.2	0.3	0.5	-0.5	0.5	0.5	0.7	0.4	0.5	-0.6	-0.7	-0.5	-0.4	0.2	0.5	-0.6
Lung cancer (father)	0.2	0.2	0.7	-0.2	-0.9	-0.7	-0.8	-0.4	-0.6	-0.4	0.0	-0.0	-0.1	-0.6	-0.5	-0.1
Arm fat mass (right)	0.2	0.9	2.4	-1.1	-0.4	0.1	1.0	0.2	0.3	-1.3	-0.7	-0.7	-1.4	-0.5	1.6	-1.3
Breastfed as a baby	0.2	0.2	0.9	0.9	-0.0	0.4	0.3	0.2	0.1	0.2	0.4	0.5	0.3	0.4	0.9	0.6
Glaucoma (self-reported)	0.2	0.3	0.5	0.1	0.6	0.7	0.6	0.6	0.7	-0.7	0.4	-0.4	0.7	0.4	0.3	0.3
High blood pressure (siblings)	0.2	0.2	1.2	-0.4	0.0	0.3	0.6	0.6	0.7	0.4	-0.2	0.3	0.1	0.0	1.1	-0.1
Exposure to tobacco smoke outside home	0.2	0.3	1.4	0.1	-0.6	-0.6	-0.3	-0.3	-0.7	-0.2	-0.1	0.5	-0.2	-0.4	-1.2	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.8	-0.2	0.2	-0.1	-0.2	0.0	0.1	0.6	-0.7	-0.1	-0.9	0.8	-0.2	-0.5
Qualifications: College or University degree	0.2	0.6	4.7	0.2	-0.5	-0.1	-0.1	-0.5	-0.4	0.5	0.0	0.7	-0.3	-1.3	-2.2	0.6
Medication: Aspirin	0.2	0.3	1.1	0.1	0.5	0.6	-0.0	0.7	0.7	0.4	0.3	0.3	0.5	0.4	1.1	0.4
Smoking status: Previous	0.2	0.4	2.2	0.0	0.3	0.6	0.8	0.5	0.3	1.5	0.4	0.0	0.3	0.1	0.7	0.6
Arm fat percentage (left)	0.2	1.0	5.0	1.2	-0.2	0.1	0.7	0.5	-0.2	0.5	1.5	1.4	0.3	0.7	2.2	0.8
Mood swings	0.2	0.4	1.2	0.9	0.1	0.2	-0.0	0.5	-0.3	1.1	0.8	0.3	0.5	-0.2	-0.5	1.0
Arm fat mass (left)	0.2	0.9	2.7	-1.2	-0.3	0.1	1.1	0.3	0.4	-1.2	-0.7	-0.7	-1.3	-0.6	1.6	-1.3
Miserableness	0.2	0.3	0.9	-1.0	0.6	0.6	-0.2	0.5	0.5	-0.5	-0.9	-0.8	-0.3	-0.1	-0.2	-0.4
Ever taken oral contraceptive pill	0.2	0.2	0.7	0.3	-0.1	-0.8	-0.4	-0.6	-0.6	0.1	0.4	0.4	0.3	-0.3	-0.8	0.5
Eye problems/disorders: Glaucoma	0.2	0.3	1.1	0.5	0.5	0.8	0.5	0.6	0.5	0.2	0.6	-0.1	0.4	1.0	-0.2	0.3
Medication: Bendroflumethiazide	0.2	0.2	1.5	0.3	0.1	0.2	0.1	0.5	0.1	0.2	-0.1	0.1	0.6	0.8	1.2	0.4
Ever smoked	0.2	0.4	1.0	-0.9	-0.2	0.1	0.4	-0.1	0.1	0.6	-1.0	-1.0	-0.5	0.6	0.5	-0.9
Schizophrenia (2018)	0.1	0.2	0.8	-0.9	0.1	-0.4	-0.2	-0.4	-0.2	-0.2	-0.1	-0.8	-0.3	0.0	-0.0	-0.8
Crohns Disease (2017)	0.1	0.3	2.9	-0.3	0.1	0.2	-0.3	-0.0	-0.1	1.7	0.0	0.5	0.1	0.4	-0.0	0.2
Crohns Disease (2012)	0.1	0.2	0.5	0.2	-0.3	-0.0	-0.4	-0.2	0.1	0.7	0.5	0.7	0.4	-0.1	-0.6	0.5
Lupus	0.1	0.2	1.8	0.0	-0.1	-0.1	-0.4	-0.1	0.1	0.0	0.3	-0.2	-0.1	1.3	-0.4	-0.3
Schizophrenia (2014)	0.1	0.3	1.1	-0.8	0.5	-0.4	-0.1	-0.5	-0.1	-0.2	-0.2	-1.1	0.1	0.9	0.6	-0.8
Blood Platelet Count	0.1	1.3	3.2	-1.4	0.3	1.4	1.8	1.5	1.5	1.2	-0.9	0.2	-0.5	1.6	0.5	-0.5
Blood White Count	0.1	1.0	3.9	-0.6	0.9	1.4	2.0	1.6	1.0	-0.2	-0.3	0.4	0.5	-0.4	1.3	0.3
Waist Hip Ratio (WHR)	0.1	0.5	1.1	-0.3	0.8	0.7	0.4	0.7	0.7	-0.9	0.0	0.4	1.0	-1.0	-0.3	1.0
Hair Pigment	0.1	3.1	10.8	-3.3	0.2	0.3	0.5	0.1	1.2	-1.5	-2.6	-2.9	-1.1	-1.8	-0.9	-2.2
Tanning	0.1	1.4	7.1	0.7	-1.1	-1.4	-1.4	-1.4	-1.4	0.2	0.6	0.7	0.1	-0.7	-2.7	0.7
Trunk fat mass	0.1	0.2	1.3	0.1	-0.7	-0.4	0.3	-0.1	-0.4	-0.4	0.3	0.4	-0.6	-0.3	1.1	-0.1
Illnesses of siblings	0.1	0.2	1.1	0.4	-0.0	-0.1	-0.2	-0.3	-0.5	-0.2	0.3	0.3	0.4	-0.0	-1.1	0.6
Alcohol intake versus 10 years previously	0.1	0.2	0.8	0.4	0.2	-0.3	-0.4	0.0	-0.2	0.9	0.4	0.2	0.5	0.1	0.5	0.5
Illnesses of mother	0.1	0.1	0.4	0.1	0.1	0.3	-0.0	0.2	0.5	-0.5	-0.3	-0.4	0.6	-0.5	-0.2	0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.7	0.5	0.6	0.4	0.2	0.2	-0.2	0.8	0.6	0.4	-0.4	-0.2	-0.1	0.2
Wheeze or whistling in the chest in last year	0.1	0.2	1.1	-0.7	1.1	0.3	0.7	0.5	0.5	-0.3	-0.1	0.2	0.1	0.3	0.1	0.0
Number of children fathered	0.1	0.1	0.4	-0.1	0.7	0.0	-0.1	0.1	0.1	-0.3	-0.1	0.0	-0.1	0.4	-0.3	-0.1
Medication: Blood pressure	0.1	0.1	0.4	0.5	-0.2	-0.6	-0.4	-0.2	-0.4	0.0	0.5	0.3	0.0	-0.5	-0.2	0.3
Whole body fat mass	0.1	0.3	2.1	-0.2	-0.3	0.0	1.0	0.3	0.0	-0.3	0.2	0.4	-0.6	-0.2	1.4	-0.3
Leg fat mass (right)	0.1	0.4	2.8	-0.1	-0.3	0.0	1.0	0.3	-0.0	-0.2	0.0	0.2	-0.6	-0.1	1.7	-0.3
Pulse rate, automated reading	0.1	0.5	3.0	-0.0	0.2	-0.1	-0.1	-0.1	-0.3	-0.7	0.0	-0.2	-1.7	0.3	0.5	-1.4
Loneliness, isolation	0.1	0.2	0.7	-0.2	-0.2	-0.3	-0.4	-0.3	-0.2	-0.9	-0.2	-0.1	0.5	0.3	0.8	0.1
Risk taking	0.1	0.2	0.8	0.2	-0.3	-0.5	0.1	-0.3	-0.4	-0.5	0.4	0.9	-0.4	-0.6	-0.4	0.2
Heart disease (siblings)	0.1	0.1	0.5	0.6	-0.4	0.2	-0.1	0.2	0.4	0.2	0.6	0.4	0.7	-0.3	0.1	0.3
Leg fat mass (left)	0.1	0.4	2.0	-0.4	-0.4	0.0	0.9	0.2	-0.0	-0.4	-0.3	-0.2	-0.8	-0.3	1.4	-0.6
Major Depression (MDD)	0.0	0.0	0.3	0.0	0.0	0.0	-0.6	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

PNKP

Models

Trait associations