[Hub]/) : Traits : Impedance of leg (left) : ← →

chr15:75,122,856-78,806,023

Best TWAS P=3.24e-19 · Best GWAS P=9.55e-14 conditioned to 0.31

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Artery Tibial	TSPAN3	0.14	0.07	lasso	5	0.10	1.6e-08	7.4	-9.0	3.2e-19	-0.85	0.01	0.99	TRUE
27	GTEx	Heart Left Ventricle	CTD-2323K18.1	0.07	0.08	lasso	3	0.04	2.6e-03	4.8	-5.2	2.2e-07	-0.07	0.01	0.89	TRUE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TSPAN3	0.05	0.01	blup	43	0.01	1.5e-02	7.0	-8.2	2.2e-16	-0.76	0.01	0.43	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	TSPAN3	0.26	0.14	lasso	6	0.12	8.2e-05	-6.8	-7.9	2.2e-15	-0.48	0.07	0.65	FALSE
34	GTEx	Skin Sun Exposed Lower leg	TSPAN3	0.11	0.03	enet	8	0.10	2.5e-08	-6.8	-7.8	5.0e-15	-0.71	0.02	0.97	FALSE
42	YFS	Blood	TSPAN3	0.18	0.14	bslmm	256	0.18	5.9e-57	-5.8	-7.8	8.5e-15	-0.55	1.00	0.00	FALSE
16	GTEx	Brain Hypothalamus	RP11-797A18.4	0.21	0.18	lasso	7	0.22	7.6e-06	7.3	-7.7	1.6e-14	-0.96	0.01	0.98	FALSE
23	GTEx	Cells Transformed fibroblasts	RP11-797A18.4	0.12	0.11	lasso	8	0.12	4.0e-09	7.0	-7.6	2.4e-14	-0.98	0.01	0.99	FALSE
28	GTEx	Heart Left Ventricle	RP11-797A18.4	0.16	0.09	enet	12	0.08	3.3e-05	7.4	-7.6	2.4e-14	-0.95	0.01	0.99	FALSE
32	GTEx	Nerve Tibial	TSPAN3	0.13	0.08	lasso	2	0.07	9.0e-06	7.4	-7.5	8.9e-14	-0.98	0.01	0.99	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	RP11-797A18.4	0.12	0.22	lasso	1	0.17	3.1e-05	7.4	-7.5	9.5e-14	-1.00	0.01	0.96	FALSE
26	GTEx	Esophagus Muscularis	RP11-797A18.4	0.07	0.09	lasso	3	0.09	6.3e-06	7.4	-7.4	1.2e-13	-0.96	0.01	0.99	FALSE
36	GTEx	Testis	PSTPIP1	0.10	0.03	lasso	3	0.02	4.1e-02	7.3	-7.3	2.2e-13	-0.99	0.01	0.96	FALSE
14	GTEx	Brain Frontal Cortex BA9	RP11-797A18.4	0.35	0.35	lasso	5	0.35	4.8e-10	7.4	-7.0	2.2e-12	-0.98	0.01	0.99	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-797A18.4	0.06	0.05	lasso	3	0.06	4.1e-04	7.4	-6.9	4.0e-12	-0.97	0.01	0.97	FALSE
13	GTEx	Brain Cortex	RP11-797A18.4	0.47	0.28	enet	14	0.34	3.3e-10	7.3	-6.7	2.1e-11	-0.94	0.01	0.99	FALSE
39	GTEx	Whole Blood	TSPAN3	0.05	0.04	lasso	2	0.03	1.8e-03	-6.8	-6.6	3.3e-11	-0.44	0.06	0.62	FALSE
22	GTEx	Cells Transformed fibroblasts	TSPAN3	0.17	0.16	lasso	3	0.17	1.7e-12	7.4	-6.5	9.5e-11	-0.89	0.01	0.99	FALSE
15	GTEx	Brain Hippocampus	PEAK1	0.23	0.05	lasso	6	0.02	9.9e-02	-6.2	6.4	1.2e-10	0.32	0.13	0.10	FALSE
20	GTEx	Cells EBV-transformed lymphocytes	PSTPIP1	0.13	0.04	enet	13	0.10	4.0e-04	4.6	-6.4	1.3e-10	-0.71	0.07	0.78	FALSE
31	GTEx	Muscle Skeletal	RP11-797A18.4	0.14	0.14	lasso	6	0.18	6.6e-17	7.0	-6.4	1.4e-10	-0.92	0.04	0.96	FALSE
41	NTR	Blood	TSPAN3	0.07	0.08	lasso	9	0.09	5.1e-27	7.4	-6.4	1.4e-10	-0.94	0.01	0.99	FALSE
37	GTEx	Testis	TSPAN3	0.19	0.05	lasso	7	0.06	1.6e-03	7.4	-6.3	2.8e-10	-0.86	0.01	0.96	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	TSPAN3	0.03	0.01	blup	43	0.01	8.2e-03	3.8	-6.3	2.9e-10	-0.78	0.04	0.58	FALSE
35	GTEx	Skin Sun Exposed Lower leg	RP11-797A18.4	0.16	0.08	enet	23	0.09	1.3e-07	7.1	-6.3	3.2e-10	-0.78	0.02	0.98	FALSE
7	GTEx	Artery Tibial	LINGO1	0.08	0.04	lasso	5	0.03	2.7e-03	-6.3	-6.3	3.5e-10	-0.38	0.21	0.27	FALSE
9	GTEx	Brain Caudate basal ganglia	PSTPIP1	0.22	0.12	lasso	9	0.13	1.4e-04	7.3	6.1	1.1e-09	0.91	0.02	0.95	FALSE
40	METSIM	Adipose	PSTPIP1	0.04	0.04	lasso	3	0.04	2.3e-06	-5.6	-6.1	1.2e-09	-0.49	0.75	0.23	FALSE
43	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TSPAN3	0.05	0.00	enet	7	0.02	9.7e-03	7.4	-6.1	1.4e-09	-0.79	0.01	0.80	FALSE
2	GTEx	Adipose Subcutaneous	PEAK1	0.05	0.03	lasso	5	0.02	8.6e-03	-6.2	6.0	1.5e-09	0.32	0.29	0.06	FALSE
10	GTEx	Brain Caudate basal ganglia	RP11-797A18.4	0.21	0.14	lasso	5	0.12	2.9e-04	7.1	-6.0	2.5e-09	-0.86	0.03	0.94	FALSE
24	GTEx	Cells Transformed fibroblasts	RP11-797A18.6	0.07	0.06	lasso	4	0.06	2.2e-05	7.4	-5.9	2.8e-09	-0.82	0.01	0.98	FALSE
19	GTEx	Brain Putamen basal ganglia	RP11-797A18.4	0.27	0.06	lasso	5	0.06	1.7e-02	7.1	-5.9	4.4e-09	-0.92	0.02	0.68	FALSE
11	GTEx	Brain Cerebellar Hemisphere	RP11-797A18.4	0.14	0.12	enet	10	0.12	6.4e-04	4.9	-5.8	6.7e-09	-0.89	0.02	0.90	FALSE
29	GTEx	Lung	RP11-797A18.4	0.19	0.09	enet	21	0.17	3.5e-13	7.4	-5.7	9.2e-09	-0.81	0.01	0.99	FALSE
12	GTEx	Brain Cerebellum	RP11-797A18.4	0.29	0.20	lasso	9	0.25	4.0e-08	7.3	-5.7	1.3e-08	-0.89	0.02	0.97	FALSE
5	GTEx	Artery Coronary	RP11-797A18.3	0.12	0.03	lasso	10	0.01	1.1e-01	-2.0	-5.6	2.7e-08	-0.80	0.03	0.61	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	RP11-797A18.4	0.14	0.11	enet	10	0.15	6.0e-06	4.9	-5.5	3.0e-08	-0.81	0.02	0.96	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	PEAK1	0.17	0.12	lasso	4	0.08	2.8e-03	-5.7	5.5	3.1e-08	0.32	0.27	0.06	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SCAPER	0.06	0.00	enet	5	0.00	3.4e-01	5.7	-5.5	3.5e-08	-0.37	0.01	0.46	FALSE
8	GTEx	Artery Tibial	RP11-797A18.4	0.14	0.03	enet	25	0.09	2.3e-07	7.4	-5.5	4.2e-08	-0.75	0.01	0.99	FALSE
30	GTEx	Muscle Skeletal	HMG20A	0.04	0.00	lasso	4	0.01	7.2e-02	4.5	-5.4	5.5e-08	-0.46	0.05	0.61	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	SCAPER	0.05	0.02	blup	151	0.02	2.3e-03	3.7	-5.4	5.5e-08	-0.30	0.04	0.68	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	RP11-797A18.4	0.19	0.10	enet	31	0.15	8.0e-09	7.3	-5.4	5.6e-08	-0.77	0.02	0.98	FALSE
1	GTEx	Adipose Subcutaneous	PSTPIP1	0.07	0.05	lasso	3	0.03	1.0e-03	-5.7	-5.4	7.7e-08	-0.30	0.71	0.03	FALSE
38	GTEx	Thyroid	PEAK1	0.11	0.05	lasso	10	0.08	9.6e-07	-4.2	5.3	8.7e-08	0.21	0.95	0.03	FALSE
3	GTEx	Adipose Subcutaneous	RP11-797A18.4	0.19	0.12	lasso	8	0.16	2.1e-13	-2.0	-5.2	2.1e-07	-0.81	0.44	0.56	FALSE