[Hub]/) : Traits : Impedance of leg (left) :

chr4:24,113,074-27,132,182

Best TWAS P=1.07e-12 · Best GWAS P=1.88e-11 conditioned to 0.0911

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous ANAPC4 0.32 0.40 lasso 13 0.40 7.3e-35 -6.16 -6.3 2.2e-10 0.97 0.03 0.97 FALSE
2 GTEx Artery Aorta ANAPC4 0.40 0.43 lasso 5 0.42 5.4e-25 -6.16 -6.2 7.4e-10 0.97 0.08 0.92 FALSE
3 GTEx Artery Tibial ANAPC4 0.37 0.42 enet 48 0.46 1.0e-39 -6.16 -6.6 3.0e-11 0.92 0.11 0.89 FALSE
4 GTEx Brain Caudate basal ganglia ANAPC4 0.35 0.10 lasso 8 0.04 2.2e-02 -3.57 -5.6 1.7e-08 0.72 0.11 0.81 FALSE
5 GTEx Brain Cortex ANAPC4 0.33 0.24 enet 23 0.26 7.5e-08 -6.30 -7.0 2.0e-12 0.87 0.02 0.98 TRUE
6 GTEx Brain Nucleus accumbens basal ganglia ANAPC4 0.41 0.15 enet 30 0.20 4.2e-06 -6.32 -6.0 2.5e-09 0.81 0.04 0.94 FALSE
7 GTEx Brain Putamen basal ganglia ANAPC4 0.25 0.03 lasso 7 0.04 3.6e-02 -6.32 -5.7 1.5e-08 0.89 0.05 0.63 FALSE
8 GTEx Breast Mammary Tissue ANAPC4 0.49 0.42 lasso 8 0.42 1.5e-23 -6.16 -6.5 7.3e-11 0.96 0.11 0.89 FALSE
9 GTEx Breast Mammary Tissue (Female) ANAPC4 0.30 0.28 lasso 8 0.19 2.2e-06 -6.16 -6.2 4.2e-10 0.97 0.05 0.95 FALSE
10 GTEx Cells Transformed fibroblasts ANAPC4 0.14 0.20 lasso 8 0.19 2.3e-14 -6.16 -6.2 6.2e-10 0.97 0.02 0.98 FALSE
11 GTEx Colon Sigmoid PI4K2B 0.33 0.04 lasso 7 0.04 1.2e-02 -4.77 -5.1 2.7e-07 0.52 0.31 0.22 FALSE
12 GTEx Colon Sigmoid ANAPC4 0.28 0.27 enet 12 0.24 5.7e-09 -6.30 -6.6 3.7e-11 0.95 0.04 0.96 FALSE
13 GTEx Colon Transverse ANAPC4 0.36 0.38 lasso 8 0.41 5.5e-21 -6.16 -6.0 1.6e-09 0.96 0.05 0.95 FALSE
14 GTEx Esophagus Gastroesophageal Junction ANAPC4 0.26 0.22 enet 21 0.20 8.3e-08 -6.16 -6.4 1.2e-10 0.93 0.02 0.98 FALSE
15 GTEx Esophagus Mucosa ANAPC4 0.33 0.23 lasso 10 0.21 4.6e-14 -6.16 -6.1 1.1e-09 0.97 0.04 0.96 FALSE
16 GTEx Esophagus Muscularis PI4K2B 0.14 0.05 lasso 7 0.05 4.2e-04 -5.33 -6.3 3.4e-10 0.66 0.34 0.62 FALSE
17 GTEx Esophagus Muscularis ANAPC4 0.37 0.40 lasso 8 0.39 2.4e-25 -6.16 -6.5 8.3e-11 0.96 0.06 0.94 FALSE
18 GTEx Heart Atrial Appendage ANAPC4 0.18 0.12 lasso 9 0.10 3.4e-05 -6.16 -6.0 1.9e-09 0.97 0.01 0.99 FALSE
19 GTEx Heart Left Ventricle ANAPC4 0.13 0.10 lasso 7 0.07 1.6e-04 -6.45 -6.2 5.7e-10 0.98 0.02 0.98 FALSE
20 GTEx Liver ANAPC4 0.25 0.14 enet 16 0.02 1.1e-01 -6.16 -5.6 2.2e-08 0.78 0.02 0.88 FALSE
21 GTEx Lung ANAPC4 0.14 0.14 enet 11 0.13 4.4e-10 -6.30 -6.4 1.6e-10 0.95 0.03 0.97 FALSE
22 GTEx Muscle Skeletal ZCCHC4 0.13 0.11 lasso 4 0.11 2.7e-11 -6.13 -6.6 5.0e-11 0.85 0.06 0.94 FALSE
23 GTEx Nerve Tibial ANAPC4 0.35 0.43 enet 14 0.43 4.3e-33 -6.16 -6.0 1.7e-09 0.96 0.11 0.89 FALSE
24 GTEx Pancreas ANAPC4 0.35 0.21 lasso 13 0.19 1.8e-08 -6.30 -6.8 8.6e-12 0.90 0.03 0.97 FALSE
25 GTEx Pituitary ANAPC4 0.38 0.12 lasso 7 0.07 8.8e-03 -6.45 -6.7 2.5e-11 0.94 0.02 0.92 FALSE
26 GTEx Prostate ANAPC4 0.28 0.12 enet 11 0.12 5.2e-04 -6.16 -5.9 4.8e-09 0.86 0.02 0.94 FALSE
27 GTEx Skin Not Sun Exposed Suprapubic ANAPC4 0.40 0.45 enet 28 0.44 1.5e-26 -6.16 -5.9 4.2e-09 0.94 0.10 0.90 FALSE
28 GTEx Skin Sun Exposed Lower leg ANAPC4 0.27 0.34 enet 23 0.34 4.4e-29 -6.16 -6.1 9.2e-10 0.95 0.09 0.91 FALSE
29 GTEx Spleen ANAPC4 0.41 0.28 enet 14 0.36 3.2e-10 -5.58 -6.2 4.1e-10 0.94 0.01 0.99 FALSE
30 GTEx Stomach ANAPC4 0.28 0.34 lasso 5 0.32 5.1e-16 -6.16 -6.3 3.5e-10 0.97 0.06 0.94 FALSE
31 GTEx Testis ANAPC4 0.12 0.10 lasso 5 0.08 2.3e-04 -6.16 -6.1 9.2e-10 0.97 0.03 0.94 FALSE
32 GTEx Thyroid ANAPC4 0.27 0.23 lasso 14 0.26 8.0e-20 -6.16 -6.5 8.0e-11 0.93 0.04 0.96 FALSE
33 METSIM Adipose ANAPC4 0.19 0.28 bslmm 552 0.28 3.5e-42 -6.16 -5.6 2.1e-08 0.94 0.04 0.96 FALSE
34 METSIM Adipose CCDC149 0.06 0.03 blup 573 0.03 4.0e-05 -0.71 5.4 6.1e-08 -0.57 0.33 0.54 FALSE
35 ROSMAP Brain Pre-frontal Cortex ANAPC4 0.19 0.27 lasso 11 0.27 3.5e-35 -6.16 -6.3 2.6e-10 0.96 0.06 0.94 FALSE
36 ROSMAP Brain Pre-frontal Cortex RBPJ 0.10 0.02 bslmm 469 0.05 5.3e-07 4.33 7.1 1.1e-12 0.03 0.06 0.93 TRUE
37 YFS Blood ANAPC4 0.22 0.28 bslmm 530 0.32 4.5e-109 -6.16 -5.5 5.0e-08 0.91 0.10 0.90 FALSE
38 The Cancer Genome Atlas Breast Invasive Carcinoma ZCCHC4 0.02 0.01 blup 83 0.00 4.5e-02 -6.13 -5.5 3.1e-08 0.88 0.04 0.93 FALSE
39 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ANAPC4 0.03 0.05 enet 10 0.04 1.9e-05 -6.16 -5.7 1.4e-08 0.90 0.02 0.97 FALSE
40 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ANAPC4 0.14 0.12 enet 11 0.09 4.5e-06 -6.16 -5.5 4.3e-08 0.83 0.04 0.95 FALSE
41 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ANAPC4 0.05 0.00 blup 69 0.01 7.5e-03 -6.25 -5.4 6.7e-08 0.85 0.01 0.95 FALSE
42 The Cancer Genome Atlas Pancreatic Adenocarcinoma ANAPC4 0.10 0.04 lasso 5 0.06 1.1e-03 -6.25 -6.3 2.4e-10 0.93 0.03 0.71 FALSE
43 The Cancer Genome Atlas Prostate Adenocarcinoma ZCCHC4 0.08 0.06 enet 13 0.08 3.4e-09 -6.13 -5.4 5.3e-08 0.81 0.09 0.91 FALSE
44 The Cancer Genome Atlas Thyroid Carcinoma ANAPC4 0.06 0.02 lasso 3 0.03 1.1e-03 -4.05 -5.4 6.3e-08 0.68 0.10 0.34 FALSE
45 The Cancer Genome Atlas Thyroid Carcinoma ZCCHC4 0.07 0.06 enet 12 0.09 1.7e-09 -6.35 -6.3 3.7e-10 0.84 0.04 0.96 FALSE