[Hub]/) : Traits : Impedance of leg (left) : ← →

chr4:24,113,074-27,132,182

Best TWAS P=1.07e-12 · Best GWAS P=1.88e-11 conditioned to 0.0911

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ANAPC4	0.32	0.40	lasso	13	0.40	7.3e-35	-6.16	-6.3	2.2e-10	0.97	0.03	0.97	FALSE
2	GTEx	Artery Aorta	ANAPC4	0.40	0.43	lasso	5	0.42	5.4e-25	-6.16	-6.2	7.4e-10	0.97	0.08	0.92	FALSE
3	GTEx	Artery Tibial	ANAPC4	0.37	0.42	enet	48	0.46	1.0e-39	-6.16	-6.6	3.0e-11	0.92	0.11	0.89	FALSE
4	GTEx	Brain Caudate basal ganglia	ANAPC4	0.35	0.10	lasso	8	0.04	2.2e-02	-3.57	-5.6	1.7e-08	0.72	0.11	0.81	FALSE
5	GTEx	Brain Cortex	ANAPC4	0.33	0.24	enet	23	0.26	7.5e-08	-6.30	-7.0	2.0e-12	0.87	0.02	0.98	TRUE
6	GTEx	Brain Nucleus accumbens basal ganglia	ANAPC4	0.41	0.15	enet	30	0.20	4.2e-06	-6.32	-6.0	2.5e-09	0.81	0.04	0.94	FALSE
7	GTEx	Brain Putamen basal ganglia	ANAPC4	0.25	0.03	lasso	7	0.04	3.6e-02	-6.32	-5.7	1.5e-08	0.89	0.05	0.63	FALSE
8	GTEx	Breast Mammary Tissue	ANAPC4	0.49	0.42	lasso	8	0.42	1.5e-23	-6.16	-6.5	7.3e-11	0.96	0.11	0.89	FALSE
9	GTEx	Breast Mammary Tissue (Female)	ANAPC4	0.30	0.28	lasso	8	0.19	2.2e-06	-6.16	-6.2	4.2e-10	0.97	0.05	0.95	FALSE
10	GTEx	Cells Transformed fibroblasts	ANAPC4	0.14	0.20	lasso	8	0.19	2.3e-14	-6.16	-6.2	6.2e-10	0.97	0.02	0.98	FALSE
11	GTEx	Colon Sigmoid	PI4K2B	0.33	0.04	lasso	7	0.04	1.2e-02	-4.77	-5.1	2.7e-07	0.52	0.31	0.22	FALSE
12	GTEx	Colon Sigmoid	ANAPC4	0.28	0.27	enet	12	0.24	5.7e-09	-6.30	-6.6	3.7e-11	0.95	0.04	0.96	FALSE
13	GTEx	Colon Transverse	ANAPC4	0.36	0.38	lasso	8	0.41	5.5e-21	-6.16	-6.0	1.6e-09	0.96	0.05	0.95	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	ANAPC4	0.26	0.22	enet	21	0.20	8.3e-08	-6.16	-6.4	1.2e-10	0.93	0.02	0.98	FALSE
15	GTEx	Esophagus Mucosa	ANAPC4	0.33	0.23	lasso	10	0.21	4.6e-14	-6.16	-6.1	1.1e-09	0.97	0.04	0.96	FALSE
16	GTEx	Esophagus Muscularis	PI4K2B	0.14	0.05	lasso	7	0.05	4.2e-04	-5.33	-6.3	3.4e-10	0.66	0.34	0.62	FALSE
17	GTEx	Esophagus Muscularis	ANAPC4	0.37	0.40	lasso	8	0.39	2.4e-25	-6.16	-6.5	8.3e-11	0.96	0.06	0.94	FALSE
18	GTEx	Heart Atrial Appendage	ANAPC4	0.18	0.12	lasso	9	0.10	3.4e-05	-6.16	-6.0	1.9e-09	0.97	0.01	0.99	FALSE
19	GTEx	Heart Left Ventricle	ANAPC4	0.13	0.10	lasso	7	0.07	1.6e-04	-6.45	-6.2	5.7e-10	0.98	0.02	0.98	FALSE
20	GTEx	Liver	ANAPC4	0.25	0.14	enet	16	0.02	1.1e-01	-6.16	-5.6	2.2e-08	0.78	0.02	0.88	FALSE
21	GTEx	Lung	ANAPC4	0.14	0.14	enet	11	0.13	4.4e-10	-6.30	-6.4	1.6e-10	0.95	0.03	0.97	FALSE
22	GTEx	Muscle Skeletal	ZCCHC4	0.13	0.11	lasso	4	0.11	2.7e-11	-6.13	-6.6	5.0e-11	0.85	0.06	0.94	FALSE
23	GTEx	Nerve Tibial	ANAPC4	0.35	0.43	enet	14	0.43	4.3e-33	-6.16	-6.0	1.7e-09	0.96	0.11	0.89	FALSE
24	GTEx	Pancreas	ANAPC4	0.35	0.21	lasso	13	0.19	1.8e-08	-6.30	-6.8	8.6e-12	0.90	0.03	0.97	FALSE
25	GTEx	Pituitary	ANAPC4	0.38	0.12	lasso	7	0.07	8.8e-03	-6.45	-6.7	2.5e-11	0.94	0.02	0.92	FALSE
26	GTEx	Prostate	ANAPC4	0.28	0.12	enet	11	0.12	5.2e-04	-6.16	-5.9	4.8e-09	0.86	0.02	0.94	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	ANAPC4	0.40	0.45	enet	28	0.44	1.5e-26	-6.16	-5.9	4.2e-09	0.94	0.10	0.90	FALSE
28	GTEx	Skin Sun Exposed Lower leg	ANAPC4	0.27	0.34	enet	23	0.34	4.4e-29	-6.16	-6.1	9.2e-10	0.95	0.09	0.91	FALSE
29	GTEx	Spleen	ANAPC4	0.41	0.28	enet	14	0.36	3.2e-10	-5.58	-6.2	4.1e-10	0.94	0.01	0.99	FALSE
30	GTEx	Stomach	ANAPC4	0.28	0.34	lasso	5	0.32	5.1e-16	-6.16	-6.3	3.5e-10	0.97	0.06	0.94	FALSE
31	GTEx	Testis	ANAPC4	0.12	0.10	lasso	5	0.08	2.3e-04	-6.16	-6.1	9.2e-10	0.97	0.03	0.94	FALSE
32	GTEx	Thyroid	ANAPC4	0.27	0.23	lasso	14	0.26	8.0e-20	-6.16	-6.5	8.0e-11	0.93	0.04	0.96	FALSE
33	METSIM	Adipose	ANAPC4	0.19	0.28	bslmm	552	0.28	3.5e-42	-6.16	-5.6	2.1e-08	0.94	0.04	0.96	FALSE
34	METSIM	Adipose	CCDC149	0.06	0.03	blup	573	0.03	4.0e-05	-0.71	5.4	6.1e-08	-0.57	0.33	0.54	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	ANAPC4	0.19	0.27	lasso	11	0.27	3.5e-35	-6.16	-6.3	2.6e-10	0.96	0.06	0.94	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	RBPJ	0.10	0.02	bslmm	469	0.05	5.3e-07	4.33	7.1	1.1e-12	0.03	0.06	0.93	TRUE
37	YFS	Blood	ANAPC4	0.22	0.28	bslmm	530	0.32	4.5e-109	-6.16	-5.5	5.0e-08	0.91	0.10	0.90	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZCCHC4	0.02	0.01	blup	83	0.00	4.5e-02	-6.13	-5.5	3.1e-08	0.88	0.04	0.93	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ANAPC4	0.03	0.05	enet	10	0.04	1.9e-05	-6.16	-5.7	1.4e-08	0.90	0.02	0.97	FALSE
40	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ANAPC4	0.14	0.12	enet	11	0.09	4.5e-06	-6.16	-5.5	4.3e-08	0.83	0.04	0.95	FALSE
41	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ANAPC4	0.05	0.00	blup	69	0.01	7.5e-03	-6.25	-5.4	6.7e-08	0.85	0.01	0.95	FALSE
42	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ANAPC4	0.10	0.04	lasso	5	0.06	1.1e-03	-6.25	-6.3	2.4e-10	0.93	0.03	0.71	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZCCHC4	0.08	0.06	enet	13	0.08	3.4e-09	-6.13	-5.4	5.3e-08	0.81	0.09	0.91	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	ANAPC4	0.06	0.02	lasso	3	0.03	1.1e-03	-4.05	-5.4	6.3e-08	0.68	0.10	0.34	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	ZCCHC4	0.07	0.06	enet	12	0.09	1.7e-09	-6.35	-6.3	3.7e-10	0.84	0.04	0.96	FALSE