Hub : Genes

CCDC149

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1400	0.0350	1.1e-05	0.016	0.029	0.045	0.050	0.070	4.3e-03	1.5e-04	3.1e-06	9.7e-07	6.4e-09
2	METSIM	Adipose	0.0624	0.0229	3.3e-04	0.026	0.028	0.018	NA	0.019	8.2e-05	4.0e-05	7.9e-04	NA	7.1e-04
3	ROSMAP	Brain Pre-frontal Cortex	0.0986	0.0291	5.1e-05	0.022	0.036	0.043	0.033	0.032	7.1e-04	1.6e-05	3.0e-06	3.4e-05	5.4e-05
4	YFS	Blood	0.0839	0.0179	1.5e-13	0.034	0.053	0.054	NA	0.054	2.7e-11	5.5e-17	3.8e-17	NA	5.0e-17

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.8	2.0	0.0	1.0	0.5	1.4
Bipolar Disorder or Schizophrenia	1.1	2.7	5.8	2.4	1.0	1.6	1.2
Depressed Affect (Nagel 2018)	0.3	0.5	1.2	0.6	-0.7	0.4	-1.1
Depression (Nagel 2018)	0.5	0.7	2.4	1.5	-0.3	0.2	-0.6
Intelligence (Savage-Jansen 2018)	0.7	2.2	6.5	-0.4	0.9	-2.5	-1.1
Neuroticism (Nagel 2018)	0.4	0.9	1.4	1.2	0.9	0.9	-0.8
Schizophrenia (2018)	1.5	3.2	9.5	3.1	0.5	1.6	0.6
Schizophrenia vs Biploar Disorder	1.8	2.3	5.3	2.3	-0.3	1.9	0.7
Worry (Nagel 2018)	0.5	1.0	2.2	1.5	1.3	0.3	0.1
Alzheimer’s Disease (in mother)	0.4	0.5	1.7	-1.3	0.4	-0.2	-0.1
Alzheimer’s Disease (in father)	0.2	0.3	0.5	0.0	-0.6	0.5	0.7
Alzheimer’s Disease (including proxy)	0.4	0.5	1.8	-1.3	0.4	0.3	0.3
Crohns Disease (2017)	0.5	1.0	1.9	0.8	-0.9	1.4	0.9
Irritable Bowel Disease (IBD)	0.1	0.3	0.9	0.1	-0.5	1.0	-0.0
Ulcerative Colitis (UC)	0.1	0.1	0.4	-0.4	-0.1	-0.1	-0.6
Major Depression (MDD)	1.1	1.3	2.9	-0.6	0.1	-1.7	-1.4
Reaction Time	0.4	0.8	1.7	1.3	0.5	1.1	-0.1
Verbal and Numeric Reasoning (VNR)	1.6	3.9	7.3	-1.9	-0.4	-2.7	-2.1
Breast Cancer	0.3	0.8	2.2	0.7	0.6	1.5	0.2
Ovarian Cancer	0.2	0.3	0.9	0.1	-0.1	0.5	1.0
Prostate Cancer	1.8	2.6	6.6	-0.6	-1.2	-1.4	-2.6
Age at First Birth	0.8	1.2	1.8	1.0	-0.9	1.3	-1.0
Bipolar Disorder (2011)	2.7	2.6	5.1	-1.6	-1.0	-1.3	-2.3
Body Mass Index (BMI) (2010)	1.4	1.9	7.1	-0.4	-2.7	0.7	0.2
Coronary Artery Disease (CAD)	1.4	1.7	4.7	1.2	-0.3	2.2	0.7
Crohns Disease (2012)	0.7	1.1	3.1	0.1	-1.8	1.0	0.6
Mean Putamen Volume	0.6	0.7	2.1	-0.2	1.5	-0.5	0.7
Fasting Glucose	0.3	0.4	0.8	-0.9	-0.1	0.4	-0.8
HbA1C	0.2	0.3	0.6	-0.1	0.6	0.8	-0.1
HDL Cholesterol	0.2	0.3	0.5	0.4	0.5	-0.7	0.6
LDL Cholesterol	0.4	0.7	1.4	1.0	-0.4	0.4	1.2
Lupus	0.1	0.1	0.3	-0.2	-0.2	-0.2	-0.6
Neuroticism (2016)	0.3	0.4	1.0	0.1	0.0	0.9	-1.0
Primary Biliary Cirrhosis	0.5	0.6	1.6	-0.7	-1.3	-0.7	0.1
Rheumatoid Arthritis	0.0	0.1	0.2	-0.2	-0.4	-0.0	-0.1
Schizophrenia (2014)	1.8	3.9	10.7	3.3	0.6	1.8	1.1
Triglycerides	0.3	0.5	0.7	0.8	-0.7	0.7	0.6
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.7	0.4	-1.3	-0.5	-0.9
Ulcerative Colitis	0.6	0.8	2.2	-1.5	0.2	-1.0	0.1
Blood Eosinophil Count	0.2	1.6	2.9	1.4	-1.7	-1.1	-0.7
Blood Platelet Count	0.3	3.3	5.3	2.3	-0.8	2.1	1.7
Blood Red Count	0.0	0.1	0.2	0.2	-0.5	0.1	-0.2
Blood White Count	0.3	2.2	8.1	0.1	-2.8	-0.7	-0.5
Heel T-Score	0.2	1.3	3.0	-1.7	-0.5	-1.3	-0.5
BMI	1.3	7.7	21.4	2.0	-4.6	2.2	-0.6
Height	0.1	2.0	3.1	-1.8	0.9	-1.7	-1.1
Waist Hip Ratio (WHR)	0.4	1.7	5.0	-0.3	0.9	-2.2	-0.9
Systolic Blood Pressure	0.1	0.6	2.0	-1.4	-0.3	0.0	-0.7
Smoking Status	0.4	1.0	2.6	0.4	1.6	1.1	0.4
Allergy or Eczema	0.3	0.9	2.0	-1.4	0.0	-1.1	-0.7
Cardiovascular Disease	0.4	1.2	2.7	0.5	-1.6	1.3	0.1
Hypothyroidism (self reported)	0.0	0.1	0.3	0.1	-0.5	0.3	-0.0
Respiratory disease	0.3	0.7	2.1	-1.5	0.5	0.6	0.4
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.7	-0.2	-1.6	0.0	-0.3
Lung FEV1/FVC ratio	0.0	0.2	0.3	0.5	0.6	0.2	-0.5
Lung FVC	1.1	5.4	13.2	0.1	3.6	0.4	2.9
Neuroticism	0.3	0.6	2.1	0.2	-0.5	-0.1	-1.5
Chronotype (morning person)	0.1	0.2	0.4	0.6	0.1	0.6	0.1
Hair Pigment	0.0	0.8	2.6	0.6	-1.6	-0.2	-0.4
Tanning	0.2	2.4	3.2	-1.4	-1.5	-1.8	-1.6
Hand grip strength (left)	0.2	0.5	1.4	0.3	-0.4	1.2	-0.5
Number of treatments/medications taken	0.2	0.4	0.5	-0.7	-0.7	-0.5	-0.4
Average weekly spirits intake	0.4	0.5	1.7	-0.5	-0.2	-1.3	-0.2
Sensitivity / hurt feelings	0.3	0.5	1.3	0.4	1.1	-0.6	0.3
Frequency of depressed mood in last 2 weeks	0.9	1.2	3.2	0.3	-0.7	-1.0	-1.8
Hearing difficulty/problems: Yes	0.2	0.3	0.9	0.1	-0.9	0.3	0.5
Relative age of first facial hair	0.1	0.3	0.5	0.5	-0.7	0.6	-0.3
Other serious medical condition/disability diagnosed by doctor	4.1	5.3	10.6	2.4	-0.1	3.3	2.2
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.0	-1.4	-0.2	-0.8	0.1
Ever had hysterectomy (womb removed)	1.0	1.2	2.9	1.7	0.0	1.3	0.3
Systolic blood pressure, automated reading	0.2	0.7	1.6	-0.1	-1.3	1.0	-0.2
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.8	0.4	-0.2	1.7	0.1
Angina	3.3	4.3	9.4	-1.5	-1.9	-3.1	-1.4
Medication for hormone replacement therapy	0.8	0.9	2.8	-0.3	-1.7	0.3	0.7
Vitamin and mineral supplements	0.2	0.3	0.5	-0.7	-0.4	-0.7	-0.4
Supplements: Zinc	0.1	0.1	0.3	-0.0	-0.5	0.1	-0.1
Medication: Co-codamol	0.1	0.1	0.1	-0.2	-0.3	-0.3	-0.3
Medication: Metformin	1.2	1.8	3.1	-0.9	-1.8	-0.8	-1.6
Diabetes (father)	0.6	0.8	1.5	-0.9	1.2	-0.8	0.5
Diabetes (mother)	0.6	0.8	2.5	-0.0	1.6	0.7	0.3
Severe depression (siblings)	0.6	0.7	2.2	1.5	-0.3	0.3	-0.6
Pack years adult smoking proportion	0.6	0.9	2.6	-0.7	-0.1	0.6	1.6
Impedance of leg (right)	1.4	7.0	22.8	-0.5	4.8	-1.9	1.1
Leg fat-free mass (left)	0.6	3.4	8.0	1.0	-2.8	2.1	-0.3
Trunk fat percentage	0.3	1.1	1.9	1.4	-0.6	1.2	0.9
Hand grip strength (right)	0.2	0.4	1.1	-1.1	-0.2	-0.1	-0.7
Townsend deprivation index at recruitment	0.7	0.9	1.5	-0.7	1.2	-0.9	0.9
Current tobacco smoking	0.4	0.7	1.8	-0.3	1.3	0.7	0.6
Average weekly fortified wine intake	0.4	0.5	1.4	-0.7	0.5	-0.1	-1.2
Maternal smoking around birth	0.7	1.0	2.8	-0.3	1.7	0.9	0.6
Fed-up feelings	0.1	0.2	0.4	-0.5	0.6	-0.2	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	1.5	1.2	-0.3	0.3	0.4
Relative age voice broke	0.0	0.0	0.1	0.1	-0.0	0.4	-0.2
Taking other prescription medications	0.1	0.1	0.3	0.0	-0.5	-0.5	0.2
Age when periods started (menarche)	1.6	3.9	8.9	-3.0	0.5	-2.2	-1.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.0	-0.0	-1.0	-0.1	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.7	-0.2	0.2	-0.8	-0.7
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	3.9	-1.1	-0.5	-2.0	-0.3
Qualifications: CSEs or equivalent	0.7	0.9	1.3	0.9	0.8	1.1	1.0
Serious illness, injury or assault to yourself	1.8	2.2	3.9	1.6	0.2	2.0	1.4
High blood pressure	0.4	1.2	3.9	-0.5	-2.0	0.0	-0.8
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.3	0.2	0.1	0.3	-0.6
Multivitamins +/- minerals	0.1	0.2	0.4	0.2	0.6	0.5	0.0
Stomach or abdominal pain in last month	0.9	1.1	2.9	1.0	1.7	0.4	0.7
Supplements: Glucosamine	0.2	0.2	0.4	-0.4	-0.7	-0.5	0.0
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.8	0.9	0.7	0.6	0.2
Medication: Atenolol	0.7	0.9	1.5	-0.2	-1.1	-1.0	-1.2
Medication: Levothyroxine sodium	0.4	0.7	1.0	0.8	-1.0	-0.2	-1.0
Sitting height	0.0	0.1	0.4	-0.2	0.0	-0.6	-0.1
Chronic bronchitis/emphysema (father)	1.2	1.4	4.2	-1.0	0.7	-2.1	-0.1
High blood pressure (mother)	0.4	0.6	1.1	-0.4	-1.1	0.4	-0.9
Body mass index (BMI)	0.9	3.9	10.0	1.3	-3.2	1.9	0.5
Impedance of leg (left)	2.0	9.5	29.3	-1.0	5.4	-2.6	1.1
Leg predicted mass (left)	0.7	3.6	8.6	1.0	-2.9	2.1	-0.3
Trunk fat mass	0.3	1.2	1.6	1.1	-1.2	1.3	0.6
Waist circumference	0.3	1.3	4.3	0.5	-2.1	0.7	-0.1
Number of incorrect matches in round	0.2	0.3	1.1	-0.5	1.0	0.2	-0.2
Past tobacco smoking	0.2	0.4	1.3	-0.5	-1.2	-0.2	0.3
Alcohol usually taken with meals	0.4	0.7	1.1	-0.0	-1.0	-1.1	-0.8
Nervous feelings	0.7	1.3	2.9	1.4	1.7	-0.5	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.2	1.5	0.9	-0.2	0.6
Hearing difficulty/problems with background noise	0.4	0.7	1.2	-0.6	-0.6	-1.1	-0.9
Hair/balding pattern: Pattern 2	1.6	2.0	5.4	0.9	-0.4	2.3	1.3
Had menopause	1.1	1.4	3.2	-1.3	0.2	-1.8	-0.8
Had other major operations	0.7	0.8	3.1	0.4	-0.0	-0.1	1.8
Forced vital capacity (FVC)	0.2	0.7	2.1	-0.6	1.4	-0.4	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.7	-0.7	1.3	-0.8	-0.9
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	4.1	-0.4	-2.0	0.1	-1.9
Qualifications: None of the above	0.4	0.9	2.2	1.0	0.7	0.3	1.5
Financial difficulties in last 2 years	0.6	0.8	1.5	-0.1	-0.8	1.0	1.2
Mouth/teeth dental problems	0.1	0.1	0.3	0.1	-0.6	0.2	0.3
Heart attack	3.3	4.3	8.4	-2.9	-1.7	-1.5	-1.9
Allergy	0.1	0.3	1.0	-0.2	-0.1	-1.0	-0.2
Pain all over the body in last month	0.7	0.8	1.4	0.8	-0.9	-0.2	-1.2
Diabetes (self-reported)	0.9	1.3	4.6	-0.0	-2.2	0.1	-0.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.9	-0.8	-0.2	0.4	-0.9
Medication: Ramipril	0.3	0.4	1.2	-0.2	0.4	-1.1	-0.4
Medication: Simvastatin	0.7	1.0	3.7	-0.1	0.2	-0.6	-1.9
Fluid intelligence score	2.3	4.8	9.4	-2.2	-1.2	-3.1	-1.9
Illnesses of siblings	0.3	0.4	1.0	-1.0	0.6	0.4	0.2
Neuroticism score	0.2	0.4	1.0	1.0	0.5	-0.1	-0.5
Weight	0.5	2.3	6.2	0.9	-2.5	1.4	0.1
Impedance of arm (right)	0.7	3.3	11.5	0.7	3.4	-1.1	0.3
Arm fat percentage (right)	0.7	2.7	4.0	1.9	-1.7	2.0	0.8
Trunk fat-free mass	0.2	1.3	4.0	0.2	-2.0	0.9	-0.6
Hip circumference	0.4	1.7	4.7	0.7	-2.2	1.4	-0.0
Time employed in main current job	1.0	1.2	2.7	0.3	-0.4	-1.3	-1.6
Alcohol intake versus 10 years previously	0.2	0.2	0.5	0.3	-0.7	-0.5	-0.3
Father’s age at death	1.5	2.0	3.3	-1.5	-1.5	-1.8	-0.6
Worrier / anxious feelings	0.1	0.1	0.2	0.2	0.2	-0.5	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.1	0.5	-0.3	0.0	-1.0
Falls in the last year	0.3	0.3	1.1	0.0	-1.1	0.1	0.5
Hair/balding pattern: Pattern 3	1.2	1.8	3.4	-1.5	1.2	-1.8	0.1
Number of live births	0.5	0.7	1.2	0.7	-1.1	1.0	-0.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.7	-0.5	0.8	-0.2	0.3
Pulse rate	0.4	0.6	1.7	-0.6	-0.5	0.3	1.3
Happiness	0.7	0.8	1.7	1.3	-0.9	0.3	-0.8
Noisy workplace	1.5	1.9	2.9	1.0	1.7	1.7	0.9
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.7	0.4	-0.3	0.1	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.8	-0.7	-0.3	-0.1	-1.3
Mouth/teeth dental problems: Dentures	0.3	0.6	1.5	-1.2	-0.4	-0.6	-0.5
Asthma	0.5	0.9	1.1	-1.0	1.0	0.8	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.9	-1.0	-1.4	-0.7	-0.9
Medication: Cholesterol lowering	0.1	0.1	0.3	-0.6	0.2	0.2	-0.2
Depression (self-reported)	0.7	0.9	1.7	-0.6	0.4	-1.3	-1.1
Medication: Lansoprazole	0.1	0.1	0.2	-0.1	0.3	0.4	0.2
Prospective memory result	0.1	0.2	0.2	-0.5	0.4	-0.1	-0.5
Lung cancer (father)	0.1	0.2	0.4	-0.2	-0.1	-0.5	-0.6
Illnesses of mother	1.1	1.4	3.2	1.8	1.2	0.6	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	4.6	0.4	2.1	0.8	0.9
Pulse wave Arterial Stiffness index	0.5	0.6	1.6	-0.2	1.2	0.8	-0.5
Impedance of arm (left)	0.9	4.2	14.1	-0.3	3.8	-1.7	0.2
Arm fat mass (right)	0.8	3.1	4.6	1.7	-2.1	2.1	0.6
Trunk predicted mass	0.2	1.3	4.0	0.2	-2.0	0.8	-0.6
Standing height	0.1	1.0	1.3	-0.8	1.1	-1.0	-0.9
Length of working week for main job	0.3	0.3	1.3	-0.2	1.1	-0.1	0.1
Exposure to tobacco smoke at home	0.3	0.4	0.9	0.8	0.1	1.0	0.0
Breastfed as a baby	0.3	0.3	0.6	0.8	-0.3	0.5	-0.7
Tense / ‘highly strung’	0.9	1.5	3.5	1.0	1.9	0.8	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.7	-0.1	-0.0	-1.3	-1.2
Hair/balding pattern: Pattern 4	0.5	1.3	4.4	-0.2	2.1	-0.9	0.1
Birth weight of first child	0.5	1.0	1.7	-1.1	-1.3	0.5	-0.8
Peak expiratory flow (PEF)	0.3	0.8	1.5	-0.2	1.2	0.8	1.0
Pulse wave reflection index	0.1	0.2	0.4	-0.6	-0.1	-0.1	-0.4
Ever highly irritable/argumentative for 2 days	0.8	1.0	1.6	1.3	-0.3	0.9	-1.2
Loud music exposure frequency	1.5	1.7	4.3	-1.3	-0.8	-0.3	-2.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.9	-0.9	0.2	-0.0	-0.9
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.4	0.8	-1.2	0.8	-0.1
Blood clot in the leg (DVT)	0.6	0.8	1.1	1.1	-0.9	1.0	0.5
Medication: Paracetamol	0.5	0.8	2.6	0.4	-0.5	1.6	-0.6
Headache pain in last month	0.2	0.3	0.5	0.5	-0.5	0.5	0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.3	-0.1	-0.6	-0.4	-1.2
Glaucoma (self-reported)	0.4	0.5	1.2	0.4	1.1	0.1	0.9
Gout (self-reported)	0.4	0.5	1.3	-0.3	0.1	-1.1	-0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.4	0.6	-0.6	0.6	0.3
Medication: Amlodipine	0.8	1.1	2.1	-1.3	1.5	0.5	0.5
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	-0.2	-0.1	0.4	0.0
Birth weight	0.8	1.8	4.8	1.3	-2.2	-0.6	-0.4
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.1	-1.5	1.3	-0.4	0.5
High blood pressure (siblings)	0.9	1.3	2.8	1.2	-1.7	0.9	-0.3
Forced vital capacity (FVC), Best measure	0.5	1.9	5.7	0.0	2.4	0.7	1.1
Body fat percentage	0.3	1.3	1.8	1.3	-0.7	1.3	1.1
Leg fat percentage (right)	0.3	1.1	1.3	0.9	-1.2	1.0	1.1
Arm fat-free mass (right)	0.2	1.1	3.3	0.0	-1.8	1.2	0.0
Exposure to tobacco smoke outside home	0.7	0.9	2.1	0.9	-1.4	0.9	0.1
Comparative body size at age 10	0.8	2.1	3.1	1.7	-1.4	1.8	0.6
Number of full brothers	1.2	1.5	2.2	1.2	-1.0	1.1	1.5
Worry too long after embarrassment	0.5	0.9	2.1	1.4	1.1	0.5	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	8.2	1.8	2.9	0.9	1.2
Wheeze or whistling in the chest in last year	0.5	0.9	1.5	-0.3	-1.2	1.2	0.8
Number of children fathered	0.4	0.4	0.9	-0.6	-1.0	-0.5	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.3	1.8	0.7	1.3	1.4
Age at first live birth	0.8	1.5	3.3	1.6	-0.3	1.8	-0.2
Pulse wave peak to peak time	0.5	0.6	1.6	-0.0	-1.3	-0.9	0.3
Health satisfaction	0.8	1.1	2.6	1.6	1.1	0.3	0.5
Shortness of breath walking on level ground	0.4	0.5	0.8	0.8	-0.3	-0.8	0.9
Qualifications: College or University degree	0.1	0.4	0.9	-0.4	0.6	-0.3	-1.0
Eye problems/disorders: None of the above	0.3	0.3	0.6	0.5	-0.1	-0.6	-0.7
Mouth/teeth dental problems: Loose teeth	0.9	1.0	3.0	0.0	1.7	0.2	-1.1
Emphysema/chronic bronchitis	0.5	0.6	1.8	0.2	1.3	0.7	0.1
Medication for pain relief, constipation, heartburn	0.2	0.3	0.6	0.1	0.8	-0.6	0.5
Neck or shoulder pain in last month	0.3	0.5	0.9	0.9	0.0	-0.5	0.9
Medication: Blood pressure	0.3	0.5	1.0	0.4	0.2	0.9	1.0
Angina (self-reported)	3.0	4.0	8.2	-1.4	-2.0	-2.9	-1.4
Migraine (self-reported)	0.2	0.3	1.0	0.0	0.4	-0.1	1.0
Medication: Ibuprofen	1.4	1.7	2.5	-1.5	-1.6	-0.8	-1.2
Medication: Allopurinol	0.6	0.9	1.4	-0.7	1.2	-1.2	-0.1
Medication: Omeprazole	0.2	0.3	0.5	0.6	-0.2	0.3	0.7
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.6	-0.2	0.3	0.1
Mean time to correctly identify matches	0.2	0.4	0.7	0.6	0.5	0.9	-0.4
Heart disease (mother)	0.5	0.6	1.7	-1.3	-0.4	-0.8	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	2.1	1.1	-1.4	0.7	-0.4
Whole body fat mass	0.4	1.5	2.1	1.2	-1.4	1.4	0.6
Leg fat mass (right)	0.5	1.9	3.2	1.1	-1.8	1.6	0.7
Arm predicted mass (right)	0.2	1.3	4.1	-0.1	-2.0	1.0	-0.0
Pulse rate, automated reading	0.1	0.5	1.7	-0.2	-0.0	0.4	1.3
Alcohol intake frequency.	0.7	1.7	2.2	1.5	-1.4	1.4	0.7
Comparative height size at age 10	0.1	0.5	1.6	0.3	1.3	0.4	0.4
Number of full sisters	0.2	0.2	0.5	0.2	-0.3	-0.7	0.4
Suffer from ‘nerves’	1.1	1.7	3.6	1.4	1.9	-0.2	1.1
Overall health rating	0.9	1.9	2.9	1.5	0.2	1.7	1.6
Chest pain or discomfort	3.9	5.6	8.1	-1.9	-2.7	-2.9	-1.8
Had major operations	1.0	1.2	3.3	1.8	0.2	1.2	0.1
Age at last live birth	2.0	2.9	5.8	2.4	0.2	2.1	1.2
Family relationship satisfaction	2.2	2.7	6.6	2.6	-1.5	1.2	-0.7
Leg pain on walking	0.4	0.6	1.5	-0.2	-0.6	-1.2	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	2.2	0.5	0.3	1.3	1.5
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.4	-0.6	-1.2	-0.8	-0.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.3	-0.4	1.1	-0.2	-0.9
Medication: Aspirin	0.7	1.0	3.0	-0.2	-1.7	-0.2	-0.9
Supplements: Vitamin C	1.3	1.6	2.7	1.1	-1.4	0.7	1.6
Knee pain experienced in last month	0.3	0.5	1.5	-0.0	-1.2	-0.7	0.3
Hypertension (Self-reported)	0.5	1.5	4.2	-1.0	-2.0	0.2	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.2	0.7	1.5	-0.2	0.3
Illnesses of father: Heart disease	0.2	0.3	0.5	-0.4	-0.7	-0.6	-0.2
Illnesses of siblings: Diabetes	1.6	2.0	3.4	-0.3	-1.2	-1.8	-1.7
Smoking status: Previous	0.2	0.3	0.8	0.1	0.6	0.3	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	3.1	1.8	1.3	1.3	0.8
Whole body fat-free mass	0.4	2.0	5.9	0.5	-2.4	1.4	-0.4
Leg fat-free mass (right)	0.6	3.1	7.5	0.9	-2.7	1.9	-0.5
Arm fat percentage (left)	0.5	2.0	3.0	1.3	-1.5	1.7	0.9
Average weekly red wine intake	1.5	2.2	5.1	-1.3	0.4	-2.3	-1.2
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.9	1.1	1.7	0.2	1.0
Mood swings	0.5	0.9	2.5	0.0	-1.1	-0.4	-1.6
Loneliness, isolation	1.2	1.6	2.4	1.6	1.4	1.1	1.0
Long-standing illness, disability or infirmity	0.7	1.1	2.2	0.9	-1.5	1.1	-0.3
Ever had bowel cancer screening	1.0	1.2	3.2	-0.1	-1.2	1.8	-0.1
Diabetes diagnosed by doctor	0.9	1.5	3.6	-0.7	-1.9	-0.7	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.3	1.0	0.2	-0.3	1.5
Friendships satisfaction	1.2	1.5	5.5	2.4	0.3	0.6	-0.0
Qualifications: nursing, teaching	0.4	0.7	1.9	0.0	-0.8	-0.1	-1.4
Commuting to job workplace: Walk	0.4	0.4	1.3	-0.6	0.2	-0.1	-1.1
Eye problems/disorders: Cataract	1.0	1.2	2.5	-1.5	0.1	-1.6	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.1	-0.7	-1.0	-0.4	-0.7
Medication for cholesterol	1.5	2.3	6.0	1.0	2.4	1.2	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.8	1.3	-0.3	0.4	0.9
Back pain experienced in last month	0.7	1.0	2.2	0.7	1.5	0.4	1.2
Mineral and other dietary supplements	0.4	0.6	2.0	0.0	-0.3	-0.4	-1.4
Breast cancer (self-reported)	1.6	1.9	2.5	1.3	1.5	1.1	1.6
Asthma (self-reported)	0.4	0.8	0.9	-0.9	0.9	0.8	0.9
Osteoporosis (self-reported)	0.6	0.8	2.1	0.8	1.4	0.1	0.5
Osteoarthritis (self-reported)	0.6	0.8	2.0	-0.1	-1.4	-0.1	-1.1
Medication: Aspirin	0.8	1.0	2.4	-0.1	-1.6	-0.6	-1.2
Medication: Gliclazide	0.1	0.2	0.5	-0.2	-0.0	-0.2	-0.7
Illnesses of father: None of the above (group 1)	2.3	2.8	6.8	2.0	0.6	2.6	0.4
Smoking status: Current	0.4	0.6	1.7	-0.3	1.3	0.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.8	0.2	0.9	0.3	0.2
Whole body water mass	0.4	2.1	6.1	0.5	-2.5	1.4	-0.4
Leg predicted mass (right)	0.6	3.0	7.2	0.9	-2.7	2.0	-0.4
Arm fat mass (left)	0.5	2.3	3.8	1.2	-2.0	1.8	0.7
Number of self-reported non-cancer illnesses	0.3	0.5	1.2	0.1	-0.9	1.1	0.3
Average weekly champagne plus white wine intake	0.5	0.7	2.1	0.3	-1.5	0.7	-0.5
Miserableness	0.4	0.6	1.9	1.4	-0.6	0.5	0.2
Guilty feelings	1.2	1.8	3.1	1.8	0.8	1.1	-1.6
Wears glasses or contact lenses	0.3	0.4	1.0	0.4	0.2	-1.0	-0.5
Ever taken oral contraceptive pill	0.8	0.9	3.3	-0.1	0.6	-1.8	-0.3
Hearing aid user	1.5	1.7	3.4	1.2	-1.8	-0.9	-1.0
Mother’s age at death	2.5	3.1	6.6	-0.5	-2.3	-0.8	-2.6
Financial situation satisfaction	0.7	0.9	2.7	0.5	1.6	0.9	-0.2
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.2	-1.1	-0.6	-0.5	-0.7
Commuting to job workplace: Public transport	0.7	0.8	1.9	0.3	1.4	0.9	0.8
Eye problems/disorders: Glaucoma	0.4	0.4	0.7	-0.8	0.8	-0.6	0.3
Medication: Blood pressure	1.1	2.0	5.0	-1.2	-2.2	-0.8	-1.0
Pain type(s) experienced in last month: Hip pain	1.1	1.4	5.6	0.2	-2.4	0.3	-0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.6	-0.6	-0.2	0.8	0.3
High cholesterol (Self-reported)	0.0	0.0	0.0	0.1	-0.2	-0.1	0.1
Medication: Bendroflumethiazide	0.8	1.3	2.0	-0.8	-1.4	-0.8	-1.4
Medication: Paracetamol	0.8	1.2	3.1	1.0	-0.1	1.8	-0.8
Medication: Lisinopril	1.4	1.8	5.3	-0.8	-2.3	0.7	-0.8
Medication: Atorvastatin	0.3	0.4	1.1	0.5	-1.1	0.3	-0.3
Illnesses of father: High blood pressure	0.3	0.4	0.8	-0.2	-0.1	-0.9	0.7
Alcohol drinker status: Never	0.2	0.2	0.5	0.5	-0.7	-0.2	0.4
Ever smoked	0.2	0.4	1.4	0.0	1.2	0.2	-0.4
Basal metabolic rate	0.4	2.2	5.7	0.9	-2.4	1.6	-0.3
Leg fat percentage (left)	0.2	0.9	1.4	0.8	-0.8	0.9	1.2
Arm fat-free mass (left)	0.4	2.0	6.2	0.7	-2.5	1.1	-0.3
Number of operations (self-reported)	0.3	0.5	1.5	-0.1	-1.2	0.7	0.3
Average weekly beer plus cider intake	0.9	1.4	2.5	0.1	0.9	1.5	1.6
Irritability	0.2	0.3	0.8	0.3	0.6	0.9	0.2
Risk taking	1.0	1.5	3.9	0.3	-1.3	2.0	0.6
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.9	-0.2	-0.9	0.7	-0.6
Fractured/broken bones in last 5 years	0.6	0.8	1.7	0.1	0.4	1.1	1.3
Age started oral contraceptive pill	0.8	0.9	2.9	-0.1	-0.7	-1.7	-0.7
Diastolic blood pressure, automated reading	0.3	0.8	2.1	0.5	-1.5	0.8	0.6
Ever depressed for a whole week	0.7	0.9	2.0	-0.5	0.6	-1.0	-1.4
Unable to work because of sickness or disability	0.4	0.5	1.0	-0.3	-1.0	0.4	-0.8
Commuting to job workplace: Cycle	0.9	1.1	4.4	-0.1	-0.4	0.2	-2.1
Myopia	1.2	1.7	3.8	-1.0	1.9	-1.1	0.8
Vascular/heart problems diagnosed by doctor	0.7	1.8	5.8	0.9	2.4	0.4	0.8
Cholesterol lowering medication	1.1	1.6	2.9	-0.6	-1.4	-1.7	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	0.6	0.5	0.1	0.6
Pain experienced in last month	0.2	0.3	0.6	-0.7	0.2	-0.2	-0.8
Supplements: Calcium	1.5	1.6	2.4	1.5	1.6	0.6	1.2
Basal cell carcinoma (self-reported)	0.7	0.8	3.1	0.3	0.1	-1.8	0.1
Heart attack/myocardial infarction (self-reported)	3.5	4.5	7.9	-2.8	-2.1	-1.6	-1.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	0.8	0.9	-0.9	0.7	0.4
Heart disease (siblings)	1.4	1.7	6.4	2.5	-0.4	0.2	0.6
Alcohol drinker status: Previous	0.1	0.1	0.4	0.3	-0.3	-0.2	-0.6
Pack years of smoking	0.6	0.8	2.4	-0.9	-0.2	0.2	1.6
Impedance of whole body	1.4	7.1	22.6	-0.6	4.7	-2.3	0.5
Leg fat mass (left)	0.4	1.7	2.5	1.0	-1.6	1.6	0.8
Arm predicted mass (left)	0.4	2.2	6.4	0.7	-2.5	1.4	-0.2