Hub : Genes

FABP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Colon Adenocarcinoma	0.240	0.1090	2.1e-13	0.199	0.238	0.230	NA	0.247	1.1e-11	6.0e-14	1.8e-13	NA	1.8e-14
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.195	0.0648	0.0e+00	0.190	0.185	0.206	NA	0.207	5.4e-21	2.0e-20	9.1e-23	NA	7.9e-23
3	TCGA	Rectum Adenocarcinoma	0.340	0.1540	2.2e-03	0.063	0.031	0.048	NA	0.064	1.4e-02	6.4e-02	2.9e-02	NA	1.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.4	0.7	-0.2	0.8	0.6
Bipolar Disorder or Schizophrenia	0.1	0.3	0.7	-0.4	0.8	0.2
Depressed Affect (Nagel 2018)	0.1	0.2	0.5	0.2	-0.7	0.2
Depression (Nagel 2018)	0.5	0.8	2.2	-1.5	0.2	0.3
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.7	-0.1	-0.6	-1.3
Neuroticism (Nagel 2018)	0.1	0.3	0.6	-0.1	-0.8	-0.5
Schizophrenia (2018)	0.1	0.1	0.2	-0.4	0.4	-0.2
Schizophrenia vs Biploar Disorder	1.9	2.6	5.0	-1.6	0.3	-2.2
Worry (Nagel 2018)	0.1	0.1	0.3	0.2	-0.4	-0.5
Alzheimer’s Disease (in mother)	2.0	2.3	4.4	-0.9	2.1	-1.3
Alzheimer’s Disease (in father)	3.0	3.2	7.0	-1.3	-2.6	-1.1
Alzheimer’s Disease (including proxy)	1.2	1.7	3.5	-1.3	0.2	-1.9
Crohns Disease (2017)	0.8	1.8	2.8	-1.7	1.1	1.1
Irritable Bowel Disease (IBD)	0.2	0.4	0.9	-0.5	0.4	1.0
Ulcerative Colitis (UC)	0.2	0.3	0.5	0.7	-0.0	0.6
Major Depression (MDD)	0.8	1.0	2.3	0.2	1.5	-0.7
Reaction Time	0.1	0.2	0.4	-0.2	0.3	0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.2	-0.6	0.3	-1.1
Breast Cancer	0.5	1.2	2.9	0.8	0.2	1.7
Ovarian Cancer	1.2	1.6	2.8	-1.0	-1.7	1.1
Prostate Cancer	0.9	1.3	2.3	1.5	1.1	0.6
Age at First Birth	2.1	3.1	5.5	-2.3	0.4	-1.9
Bipolar Disorder (2011)	1.1	1.1	2.1	-1.4	1.1	-0.0
Body Mass Index (BMI) (2010)	2.3	3.2	4.2	1.6	-1.6	2.0
Coronary Artery Disease (CAD)	2.4	2.9	5.6	-2.4	0.4	-1.7
Crohns Disease (2012)	0.6	1.0	1.9	-1.4	0.7	-0.7
Mean Putamen Volume	0.8	0.9	2.7	1.6	0.2	0.2
Fasting Glucose	0.3	0.4	0.8	0.0	-0.9	0.6
HbA1C	0.4	0.5	0.8	-0.7	-0.9	0.3
HDL Cholesterol	2.9	4.9	13.8	-0.8	3.7	0.3
LDL Cholesterol	0.6	0.9	2.1	1.4	0.8	-0.2
Lupus	0.4	0.5	1.5	1.2	0.4	-0.1
Neuroticism (2016)	0.7	1.1	2.3	1.5	0.8	-0.5
Primary Biliary Cirrhosis	0.9	1.3	2.3	-1.1	1.5	-0.6
Rheumatoid Arthritis	0.2	0.3	0.3	0.6	-0.5	0.5
Schizophrenia (2014)	0.3	0.7	2.0	-0.5	1.4	-0.2
Triglycerides	1.3	2.1	3.2	1.8	-1.6	0.7
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.4	-1.5	-0.6	0.6
Ulcerative Colitis	0.3	0.4	0.9	1.0	-0.3	-0.5
Blood Eosinophil Count	0.3	2.4	6.8	-0.1	-2.6	0.7
Blood Platelet Count	2.0	23.6	38.2	-6.2	4.6	-3.4
Blood Red Count	0.1	0.6	0.6	0.7	0.8	0.8
Blood White Count	1.3	9.9	17.6	-4.2	3.4	-0.8
Heel T-Score	0.2	1.9	2.9	0.3	-1.7	-1.6
BMI	1.7	10.0	15.9	3.7	-4.0	0.6
Height	0.8	15.5	36.6	-6.0	0.6	3.1
Waist Hip Ratio (WHR)	1.3	5.9	8.6	-2.8	-1.1	2.9
Systolic Blood Pressure	1.3	6.3	12.2	-2.4	3.5	-0.9
Smoking Status	0.3	0.8	1.9	-0.7	-1.4	-0.2
Allergy or Eczema	0.3	0.9	1.1	-1.1	-1.0	-0.6
Cardiovascular Disease	1.0	3.3	6.9	-1.3	1.1	-2.6
Hypothyroidism (self reported)	0.1	0.2	0.6	-0.7	-0.0	-0.4
Respiratory disease	0.2	0.4	1.1	-0.2	-1.1	-0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	0.3	0.4	-0.5
Lung FEV1/FVC ratio	1.0	5.0	7.9	-1.5	2.8	-2.2
Lung FVC	0.1	0.6	1.0	0.5	-1.0	0.7
Neuroticism	0.1	0.3	0.9	0.9	0.1	0.3
Chronotype (morning person)	0.9	2.2	2.9	1.7	-1.3	-1.4
Hair Pigment	0.0	0.2	0.2	-0.3	0.5	-0.5
Tanning	0.1	1.8	4.6	2.1	-0.3	0.8
Hand grip strength (left)	0.1	0.3	0.7	-0.3	-0.8	-0.2
Number of treatments/medications taken	0.6	1.1	2.6	-0.7	-0.2	-1.6
Average weekly spirits intake	0.1	0.1	0.2	-0.1	-0.5	-0.0
Sensitivity / hurt feelings	0.3	0.5	1.1	-0.0	-0.7	-1.0
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.6	-0.6	0.4	0.7
Hearing difficulty/problems: Yes	0.7	1.1	2.6	-0.4	-1.6	-0.7
Relative age of first facial hair	0.2	0.4	0.9	0.6	0.0	0.9
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	0.1	0.8	0.7
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.5	1.1	-1.6	0.4
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.4	0.2	-0.4
Systolic blood pressure, automated reading	0.5	1.5	2.2	-0.6	1.5	-1.4
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.8	0.1	1.7	-0.7
Angina	2.9	3.7	7.8	-2.8	-0.0	-1.9
Medication for hormone replacement therapy	1.8	2.1	4.2	0.6	-1.3	-2.1
Vitamin and mineral supplements	0.2	0.3	0.5	0.5	0.7	0.2
Supplements: Zinc	0.3	0.4	0.6	-0.1	0.7	0.8
Medication: Co-codamol	0.2	0.3	0.8	-0.1	-0.9	-0.0
Medication: Metformin	0.6	0.9	2.4	0.5	1.6	-0.2
Diabetes (father)	0.2	0.3	0.4	0.6	-0.2	-0.6
Diabetes (mother)	0.7	0.9	0.9	0.9	-1.0	0.9
Severe depression (siblings)	0.3	0.4	0.7	0.6	0.1	0.9
Pack years adult smoking proportion	0.4	0.6	1.5	1.2	0.3	-0.4
Impedance of leg (right)	7.7	37.1	98.4	-9.9	3.5	-0.6
Leg fat-free mass (left)	1.1	6.0	9.4	2.6	-3.1	1.3
Trunk fat percentage	1.2	4.8	8.3	-2.9	-2.5	-0.2
Hand grip strength (right)	0.1	0.2	0.6	-0.0	-0.8	-0.2
Townsend deprivation index at recruitment	1.4	2.0	3.8	1.2	-1.9	0.9
Current tobacco smoking	0.8	1.3	1.9	-0.2	-1.4	-1.4
Average weekly fortified wine intake	0.9	1.0	1.6	-1.2	1.3	0.2
Maternal smoking around birth	0.2	0.3	0.7	0.9	0.4	0.2
Fed-up feelings	0.2	0.3	0.9	0.9	0.2	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	-0.4	0.2	0.9
Relative age voice broke	0.3	0.5	1.3	0.3	-0.0	1.1
Taking other prescription medications	0.6	0.9	1.6	-1.3	-0.1	-1.0
Age when periods started (menarche)	0.8	2.0	5.6	-2.4	0.2	-0.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.1	0.6	-0.2	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.7	-0.4	-1.0	-1.3
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	-0.7	-0.2	0.1
Qualifications: CSEs or equivalent	0.3	0.5	1.3	0.1	0.2	1.2
Serious illness, injury or assault to yourself	1.6	2.0	4.1	-0.2	2.0	1.3
High blood pressure	0.5	1.5	3.6	-0.5	0.9	-1.9
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	-0.4	-0.1	-0.3
Multivitamins +/- minerals	0.3	0.3	0.9	1.0	-0.2	0.3
Stomach or abdominal pain in last month	0.6	0.8	0.8	0.9	0.9	-0.8
Supplements: Glucosamine	3.3	4.3	10.8	1.2	-0.7	3.3
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	1.8	-1.3	1.2	-1.2
Medication: Atenolol	0.7	0.9	1.9	0.2	0.9	-1.4
Medication: Levothyroxine sodium	0.2	0.4	0.7	0.6	-0.5	-0.8
Sitting height	0.4	3.0	4.7	-0.1	-2.2	2.1
Chronic bronchitis/emphysema (father)	1.8	2.1	4.3	2.1	0.3	1.4
High blood pressure (mother)	0.1	0.2	0.5	0.0	-0.2	0.7
Body mass index (BMI)	1.5	6.3	12.5	2.5	-3.5	-0.0
Impedance of leg (left)	6.7	32.6	83.7	-9.1	3.7	-0.6
Leg predicted mass (left)	1.2	6.1	9.7	2.6	-3.1	1.3
Trunk fat mass	1.0	4.1	8.4	-1.9	-2.9	0.2
Waist circumference	1.1	4.1	9.9	0.2	-3.1	1.5
Number of incorrect matches in round	0.2	0.3	0.9	0.3	-0.1	-0.9
Past tobacco smoking	0.4	0.7	1.0	0.3	1.0	-1.0
Alcohol usually taken with meals	0.3	0.6	1.2	-0.7	-0.1	-1.1
Nervous feelings	0.1	0.2	0.3	0.0	0.6	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.1	0.5	-1.1	0.5
Hearing difficulty/problems with background noise	1.5	2.3	6.1	0.8	-2.5	0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.2	-0.1	-0.4
Had menopause	1.9	2.4	5.1	0.8	-1.1	-2.3
Had other major operations	1.8	2.2	4.1	0.8	-2.0	1.4
Forced vital capacity (FVC)	1.0	3.9	7.0	-2.6	0.5	2.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	1.6	-0.9	-1.1	-1.2
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	3.7	-0.3	1.9	0.7
Qualifications: None of the above	0.2	0.3	0.6	0.4	0.5	-0.8
Financial difficulties in last 2 years	1.3	1.8	4.3	-2.1	-0.0	1.0
Mouth/teeth dental problems	0.4	0.7	1.1	-1.1	0.7	0.7
Heart attack	1.7	2.1	4.6	-1.2	0.5	-2.1
Allergy	0.2	0.5	1.5	1.2	-0.2	-0.1
Pain all over the body in last month	0.4	0.5	0.8	-0.8	-0.9	-0.2
Diabetes (self-reported)	0.5	0.8	1.4	0.1	1.2	-1.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.6	0.3	-1.2	0.1
Medication: Ramipril	0.3	0.4	0.6	-0.4	-0.7	0.7
Medication: Simvastatin	0.5	0.7	1.8	0.4	-0.0	-1.4
Fluid intelligence score	0.3	0.7	1.4	0.5	1.2	-0.7
Illnesses of siblings	0.3	0.5	1.2	-0.3	-0.3	1.1
Neuroticism score	0.2	0.3	0.6	0.8	-0.6	-0.1
Weight	0.8	4.1	11.2	0.3	-3.4	1.0
Impedance of arm (right)	3.0	14.0	33.6	-5.8	2.9	0.4
Arm fat percentage (right)	0.7	2.9	8.8	-0.1	-3.0	-0.0
Trunk fat-free mass	0.6	3.7	5.0	2.0	-2.2	1.5
Hip circumference	0.5	1.9	5.8	0.2	-2.4	-0.1
Time employed in main current job	0.2	0.2	0.4	0.2	0.6	-0.5
Alcohol intake versus 10 years previously	1.1	1.6	3.3	1.1	-1.8	-0.3
Father’s age at death	0.1	0.1	0.1	0.3	0.2	0.4
Worrier / anxious feelings	0.1	0.1	0.3	0.3	-0.5	-0.3
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	4.1	1.5	0.0	2.0
Falls in the last year	1.4	1.9	3.8	-0.2	-1.9	1.4
Hair/balding pattern: Pattern 3	0.2	0.4	0.6	0.3	-0.6	0.8
Number of live births	0.0	0.0	0.1	-0.0	-0.4	0.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	5.3	-2.3	1.1	1.1
Pulse rate	1.3	2.2	4.6	0.6	2.1	1.3
Happiness	0.6	0.7	1.2	-1.0	1.1	-0.0
Noisy workplace	0.9	1.1	2.1	-1.5	-0.0	-1.1
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	-0.4	0.0	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.4	-1.2	0.3	0.3
Mouth/teeth dental problems: Dentures	0.6	1.0	2.0	1.4	-0.8	-0.6
Asthma	0.4	0.8	1.2	-0.1	-1.1	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.6	0.2	0.8	0.8
Medication: Cholesterol lowering	2.3	3.6	7.0	-1.9	0.5	-2.6
Depression (self-reported)	0.0	0.0	0.1	-0.1	-0.3	0.0
Medication: Lansoprazole	0.3	0.3	0.9	0.9	-0.3	-0.0
Prospective memory result	1.0	1.2	1.9	1.4	-1.2	0.4
Lung cancer (father)	1.1	1.3	2.2	0.3	1.5	1.2
Illnesses of mother	0.1	0.2	0.4	0.3	-0.7	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	2.9	-1.7	1.2	1.1
Pulse wave Arterial Stiffness index	1.3	1.5	4.2	2.0	-0.0	0.5
Impedance of arm (left)	3.0	13.8	32.9	-5.7	2.9	-0.2
Arm fat mass (right)	1.0	4.0	11.6	0.5	-3.4	0.3
Trunk predicted mass	0.7	4.0	5.2	2.1	-2.3	1.5
Standing height	0.9	9.3	23.5	-4.8	-0.1	2.1
Length of working week for main job	0.4	0.5	0.7	0.8	-0.8	-0.3
Exposure to tobacco smoke at home	0.5	0.5	1.3	0.1	0.5	-1.2
Breastfed as a baby	0.9	1.1	3.1	-0.2	0.4	-1.8
Tense / ‘highly strung’	0.7	1.1	1.8	0.7	-0.9	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	4.3	0.7	1.2	2.1
Hair/balding pattern: Pattern 4	1.6	3.8	8.6	-0.8	-1.5	-2.9
Birth weight of first child	2.6	4.7	10.2	3.2	-1.3	1.5
Peak expiratory flow (PEF)	0.1	0.2	0.5	-0.7	0.2	0.3
Pulse wave reflection index	3.9	4.8	7.2	2.7	-2.7	-0.0
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.2	-1.1	-0.0	0.3
Loud music exposure frequency	0.7	0.7	1.3	-1.1	-0.9	0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	-0.6	-0.8	-0.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	0.2	0.3	-0.5
Blood clot in the leg (DVT)	1.3	1.6	4.0	-0.6	0.7	-2.0
Medication: Paracetamol	0.8	1.3	3.9	0.1	-0.2	2.0
Headache pain in last month	0.3	0.4	1.0	1.0	-0.4	0.3
Medication for cholesterol, blood pressure or diabetes	3.5	5.9	12.4	2.3	-0.1	3.5
Glaucoma (self-reported)	0.8	0.9	2.4	-0.6	1.5	-0.4
Gout (self-reported)	0.3	0.4	0.4	0.5	0.7	0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.4	0.2	-0.6	-0.6
Medication: Amlodipine	0.1	0.2	0.3	-0.4	-0.1	-0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	0.2	0.2	1.0
Birth weight	0.3	0.8	2.2	-0.2	-0.1	1.5
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.9	-0.7	-1.7	-0.2
High blood pressure (siblings)	0.3	0.5	0.7	0.8	0.1	-0.8
Forced vital capacity (FVC), Best measure	0.6	2.2	3.5	-1.9	0.6	1.6
Body fat percentage	1.1	4.5	6.8	-2.6	-2.6	-0.3
Leg fat percentage (right)	1.4	5.1	8.0	-2.7	-2.8	-0.6
Arm fat-free mass (right)	0.7	3.5	5.8	2.0	-2.4	1.0
Exposure to tobacco smoke outside home	1.4	1.8	3.5	0.5	-1.9	-1.3
Comparative body size at age 10	0.3	0.7	0.9	0.6	-0.9	-0.9
Number of full brothers	0.3	0.4	0.7	-0.8	0.4	0.6
Worry too long after embarrassment	0.1	0.1	0.2	0.5	0.4	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.7	1.3	0.0	1.0
Wheeze or whistling in the chest in last year	1.6	2.8	6.0	2.4	-0.9	1.3
Number of children fathered	0.5	0.6	0.9	-0.6	-0.9	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.9	-0.8	-0.2	-2.0
Age at first live birth	1.9	3.5	7.2	-2.7	1.5	-1.0
Pulse wave peak to peak time	1.9	2.3	6.5	-2.5	0.3	-0.5
Health satisfaction	0.6	0.8	1.4	1.2	0.3	0.9
Shortness of breath walking on level ground	0.5	0.6	0.7	0.8	0.7	-0.8
Qualifications: College or University degree	0.4	1.3	2.8	1.0	1.7	-0.1
Eye problems/disorders: None of the above	0.6	0.7	1.7	1.3	-0.2	0.7
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.6	-0.6	1.3	-0.2
Emphysema/chronic bronchitis	0.2	0.2	0.4	0.5	0.6	0.0
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	0.6	0.2	-0.5
Neck or shoulder pain in last month	1.6	2.2	2.9	1.5	-1.2	1.7
Medication: Blood pressure	2.5	4.3	9.1	-2.0	-0.0	-3.0
Angina (self-reported)	3.6	4.7	8.7	-2.9	-0.1	-2.3
Migraine (self-reported)	0.4	0.5	1.3	0.5	-0.0	-1.2
Medication: Ibuprofen	0.3	0.3	0.6	0.5	0.2	0.8
Medication: Allopurinol	1.1	1.4	2.5	1.6	0.7	1.2
Medication: Omeprazole	0.6	0.7	1.8	-1.3	0.6	-0.3
Medication: Seretide 50 evohaler	0.4	0.4	0.5	0.7	-0.5	0.7
Mean time to correctly identify matches	0.1	0.2	0.3	0.2	0.5	0.5
Heart disease (mother)	1.0	1.2	3.6	-0.3	1.9	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	-0.3	-0.4	-0.2
Whole body fat mass	0.9	3.7	9.0	-1.5	-3.0	0.1
Leg fat mass (right)	1.2	4.6	12.4	-1.2	-3.5	-0.1
Arm predicted mass (right)	0.6	3.2	5.9	1.8	-2.4	0.6
Pulse rate, automated reading	1.1	3.7	10.0	-0.3	3.2	1.0
Alcohol intake frequency.	1.2	2.8	7.6	2.8	-0.7	0.5
Comparative height size at age 10	0.7	3.7	5.3	-2.3	0.9	2.2
Number of full sisters	0.5	0.6	1.4	-0.3	-1.2	-0.6
Suffer from ‘nerves’	0.2	0.3	0.7	0.8	-0.5	0.2
Overall health rating	0.3	0.6	1.0	0.1	1.0	1.0
Chest pain or discomfort	0.2	0.3	0.7	-0.9	0.2	0.4
Had major operations	1.1	1.3	1.9	1.4	1.3	0.6
Age at last live birth	3.9	5.7	8.6	-2.9	1.8	-2.3
Family relationship satisfaction	0.5	0.7	1.7	0.2	1.3	-0.5
Leg pain on walking	0.3	0.4	0.9	0.5	-0.4	0.9
Qualifications: NVQ or HND or HNC or equivalent	3.1	3.8	7.4	0.2	-2.0	2.7
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.0	0.7	-1.0	0.0
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.2	1.1	0.2	-1.5
Medication: Aspirin	1.2	1.6	3.1	-1.0	-0.8	-1.8
Supplements: Vitamin C	0.7	0.8	1.9	-1.4	-0.6	-0.5
Knee pain experienced in last month	1.9	2.9	3.9	1.7	-1.4	2.0
Hypertension (Self-reported)	0.7	2.1	5.3	0.0	1.0	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.3	-0.6	-0.3	-1.5
Illnesses of father: Heart disease	1.5	2.1	4.7	-2.2	0.4	-1.2
Illnesses of siblings: Diabetes	0.6	0.8	2.0	0.1	0.5	1.4
Smoking status: Previous	0.7	1.1	3.3	-0.1	0.3	1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	7.6	-2.8	-0.0	0.5
Whole body fat-free mass	0.8	4.9	6.8	2.4	-2.6	1.3
Leg fat-free mass (right)	1.4	7.3	11.7	3.4	-2.9	1.4
Arm fat percentage (left)	0.7	2.9	8.8	0.1	-3.0	-0.1
Average weekly red wine intake	1.4	2.0	3.2	-1.8	1.2	-1.2
Handedness (chirality/laterality): Left-handed	1.5	1.8	2.7	1.7	0.2	1.6
Mood swings	0.8	1.4	2.1	1.4	-1.5	0.2
Loneliness, isolation	0.5	0.7	1.8	-1.3	-0.4	0.2
Long-standing illness, disability or infirmity	0.2	0.4	1.0	0.3	1.0	-0.2
Ever had bowel cancer screening	0.7	0.8	1.2	1.1	0.8	0.7
Diabetes diagnosed by doctor	0.7	1.1	2.9	0.0	0.6	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	4.4	2.1	0.2	0.7
Friendships satisfaction	0.9	1.1	3.2	0.4	1.8	0.3
Qualifications: nursing, teaching	0.6	1.0	2.2	0.4	-0.8	1.5
Commuting to job workplace: Walk	1.1	1.2	3.2	-0.5	1.8	0.1
Eye problems/disorders: Cataract	0.3	0.4	1.1	-1.1	-0.1	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.4	-1.2	-0.1	-0.7
Medication for cholesterol	0.5	0.7	1.6	-0.6	-0.2	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	2.9	4.4	0.7	-2.1	2.0
Back pain experienced in last month	0.8	1.2	2.3	1.5	-0.8	0.9
Mineral and other dietary supplements	0.3	0.4	1.0	0.3	0.1	-1.0
Breast cancer (self-reported)	1.2	1.4	2.9	-1.1	1.7	0.3
Asthma (self-reported)	0.4	0.7	1.7	-0.3	-1.3	0.7
Osteoporosis (self-reported)	0.4	0.4	1.2	0.3	-1.1	0.2
Osteoarthritis (self-reported)	1.5	2.0	5.3	0.7	0.6	2.3
Medication: Aspirin	1.2	1.6	3.5	-0.7	-0.9	-1.9
Medication: Gliclazide	1.2	1.3	3.6	1.9	0.6	0.0
Illnesses of father: None of the above (group 1)	0.7	0.8	1.3	1.1	-1.1	0.1
Smoking status: Current	1.1	1.7	3.0	0.2	-1.7	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.2	-0.0	0.1	-0.4
Whole body water mass	0.9	5.2	7.0	2.6	-2.6	1.3
Leg predicted mass (right)	1.4	7.5	12.4	3.5	-2.9	1.4
Arm fat mass (left)	1.0	4.0	11.4	0.7	-3.4	0.3
Number of self-reported non-cancer illnesses	0.3	0.5	1.5	0.1	-0.3	-1.2
Average weekly champagne plus white wine intake	0.5	0.7	1.2	-1.1	-0.3	0.9
Miserableness	0.3	0.5	0.7	0.7	-0.8	-0.4
Guilty feelings	0.1	0.2	0.5	0.7	0.1	0.0
Wears glasses or contact lenses	2.0	2.3	6.4	0.7	-2.5	0.2
Ever taken oral contraceptive pill	0.1	0.1	0.1	0.3	-0.3	-0.3
Hearing aid user	0.4	0.5	0.7	-0.7	-0.9	-0.4
Mother’s age at death	0.9	1.2	1.9	-1.3	-1.4	-0.1
Financial situation satisfaction	0.7	0.8	2.2	-1.5	-0.3	0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.2	-0.4	-0.1
Commuting to job workplace: Public transport	0.3	0.4	1.2	-0.2	1.1	0.1
Eye problems/disorders: Glaucoma	1.7	2.0	5.9	-0.3	2.4	-0.3
Medication: Blood pressure	0.4	0.7	1.0	1.0	0.8	0.6
Pain type(s) experienced in last month: Hip pain	0.4	0.4	0.9	1.0	0.6	-0.3
Supplements: Fish oil (including cod liver oil)	1.0	1.3	1.7	-1.1	1.1	1.3
High cholesterol (Self-reported)	0.2	0.4	0.8	0.6	0.9	-0.3
Medication: Bendroflumethiazide	0.2	0.3	0.7	0.2	0.8	-0.2
Medication: Paracetamol	0.7	1.1	2.8	0.6	-0.4	1.7
Medication: Lisinopril	0.8	1.0	2.5	-0.8	-0.1	-1.6
Medication: Atorvastatin	1.7	2.1	3.7	-1.2	1.9	-1.1
Illnesses of father: High blood pressure	2.4	3.0	7.4	0.4	2.7	1.2
Alcohol drinker status: Never	0.4	0.5	1.2	0.3	-1.1	-0.3
Ever smoked	0.5	0.8	1.8	-0.8	-1.3	-0.2
Basal metabolic rate	0.8	4.3	8.2	1.8	-2.9	1.2
Leg fat percentage (left)	1.1	3.9	7.3	-2.0	-2.7	-0.5
Arm fat-free mass (left)	0.7	3.5	6.6	1.8	-2.6	0.9
Number of operations (self-reported)	0.8	1.3	1.9	1.2	-1.4	0.6
Average weekly beer plus cider intake	1.4	2.0	5.8	0.2	-0.4	2.4
Irritability	0.3	0.6	1.6	-0.0	-1.3	0.3
Risk taking	1.2	1.8	2.8	1.7	0.8	1.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.4	0.4	-0.2
Fractured/broken bones in last 5 years	0.5	0.7	1.9	0.1	1.4	0.2
Age started oral contraceptive pill	0.2	0.3	0.7	0.9	0.1	-0.4
Diastolic blood pressure, automated reading	1.9	5.7	10.4	-2.3	3.2	-1.3
Ever depressed for a whole week	0.8	1.0	1.8	0.2	1.4	1.0
Unable to work because of sickness or disability	0.2	0.2	0.4	0.2	0.7	0.5
Commuting to job workplace: Cycle	0.6	0.7	1.4	0.6	-1.2	0.6
Myopia	1.3	1.9	3.7	-1.2	-0.6	-1.9
Vascular/heart problems diagnosed by doctor	1.0	2.8	7.1	0.9	-0.6	2.7
Cholesterol lowering medication	0.3	0.4	0.8	0.9	0.5	0.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.7	-1.3	1.0	0.1
Pain experienced in last month	2.2	3.6	8.4	-2.9	0.1	-1.6
Supplements: Calcium	0.1	0.1	0.1	-0.3	-0.3	-0.3
Basal cell carcinoma (self-reported)	1.2	1.4	2.4	1.3	-1.6	0.5
Heart attack/myocardial infarction (self-reported)	1.7	2.2	5.4	-1.0	0.5	-2.3
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	2.8	-0.1	0.7	-1.7
Heart disease (siblings)	1.1	1.4	3.9	-0.4	-0.2	-2.0
Alcohol drinker status: Previous	0.7	0.8	1.5	0.8	1.2	0.5
Pack years of smoking	0.6	0.8	2.3	1.5	0.1	-0.3
Impedance of whole body	5.3	26.7	67.4	-8.2	3.5	-0.6
Leg fat mass (left)	1.0	3.9	10.9	-0.8	-3.3	0.1
Arm predicted mass (left)	0.8	4.2	9.7	1.5	-3.1	0.8