Hub : Genes

FABP2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Colon Adenocarcinoma 0.240 0.1090 2.1e-13 0.199 0.238 0.230 NA 0.247 1.1e-11 6.0e-14 1.8e-13 NA 1.8e-14
2 TCGA Kidney Renal Clear Cell Carcinoma 0.195 0.0648 0.0e+00 0.190 0.185 0.206 NA 0.207 5.4e-21 2.0e-20 9.1e-23 NA 7.9e-23
3 TCGA Rectum Adenocarcinoma 0.340 0.1540 2.2e-03 0.063 0.031 0.048 NA 0.064 1.4e-02 6.4e-02 2.9e-02 NA 1.3e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.2 0.4 0.7 -0.2 0.8 0.6
Bipolar Disorder or Schizophrenia 0.1 0.3 0.7 -0.4 0.8 0.2
Depressed Affect (Nagel 2018) 0.1 0.2 0.5 0.2 -0.7 0.2
Depression (Nagel 2018) 0.5 0.8 2.2 -1.5 0.2 0.3
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.7 -0.1 -0.6 -1.3
Neuroticism (Nagel 2018) 0.1 0.3 0.6 -0.1 -0.8 -0.5
Schizophrenia (2018) 0.1 0.1 0.2 -0.4 0.4 -0.2
Schizophrenia vs Biploar Disorder 1.9 2.6 5.0 -1.6 0.3 -2.2
Worry (Nagel 2018) 0.1 0.1 0.3 0.2 -0.4 -0.5
Alzheimer’s Disease (in mother) 2.0 2.3 4.4 -0.9 2.1 -1.3
Alzheimer’s Disease (in father) 3.0 3.2 7.0 -1.3 -2.6 -1.1
Alzheimer’s Disease (including proxy) 1.2 1.7 3.5 -1.3 0.2 -1.9
Crohns Disease (2017) 0.8 1.8 2.8 -1.7 1.1 1.1
Irritable Bowel Disease (IBD) 0.2 0.4 0.9 -0.5 0.4 1.0
Ulcerative Colitis (UC) 0.2 0.3 0.5 0.7 -0.0 0.6
Major Depression (MDD) 0.8 1.0 2.3 0.2 1.5 -0.7
Reaction Time 0.1 0.2 0.4 -0.2 0.3 0.7
Verbal and Numeric Reasoning (VNR) 0.2 0.6 1.2 -0.6 0.3 -1.1
Breast Cancer 0.5 1.2 2.9 0.8 0.2 1.7
Ovarian Cancer 1.2 1.6 2.8 -1.0 -1.7 1.1
Prostate Cancer 0.9 1.3 2.3 1.5 1.1 0.6
Age at First Birth 2.1 3.1 5.5 -2.3 0.4 -1.9
Bipolar Disorder (2011) 1.1 1.1 2.1 -1.4 1.1 -0.0
Body Mass Index (BMI) (2010) 2.3 3.2 4.2 1.6 -1.6 2.0
Coronary Artery Disease (CAD) 2.4 2.9 5.6 -2.4 0.4 -1.7
Crohns Disease (2012) 0.6 1.0 1.9 -1.4 0.7 -0.7
Mean Putamen Volume 0.8 0.9 2.7 1.6 0.2 0.2
Fasting Glucose 0.3 0.4 0.8 0.0 -0.9 0.6
HbA1C 0.4 0.5 0.8 -0.7 -0.9 0.3
HDL Cholesterol 2.9 4.9 13.8 -0.8 3.7 0.3
LDL Cholesterol 0.6 0.9 2.1 1.4 0.8 -0.2
Lupus 0.4 0.5 1.5 1.2 0.4 -0.1
Neuroticism (2016) 0.7 1.1 2.3 1.5 0.8 -0.5
Primary Biliary Cirrhosis 0.9 1.3 2.3 -1.1 1.5 -0.6
Rheumatoid Arthritis 0.2 0.3 0.3 0.6 -0.5 0.5
Schizophrenia (2014) 0.3 0.7 2.0 -0.5 1.4 -0.2
Triglycerides 1.3 2.1 3.2 1.8 -1.6 0.7
Type 2 Diabetes (T2D) (2012) 0.9 1.0 2.4 -1.5 -0.6 0.6
Ulcerative Colitis 0.3 0.4 0.9 1.0 -0.3 -0.5
Blood Eosinophil Count 0.3 2.4 6.8 -0.1 -2.6 0.7
Blood Platelet Count 2.0 23.6 38.2 -6.2 4.6 -3.4
Blood Red Count 0.1 0.6 0.6 0.7 0.8 0.8
Blood White Count 1.3 9.9 17.6 -4.2 3.4 -0.8
Heel T-Score 0.2 1.9 2.9 0.3 -1.7 -1.6
BMI 1.7 10.0 15.9 3.7 -4.0 0.6
Height 0.8 15.5 36.6 -6.0 0.6 3.1
Waist Hip Ratio (WHR) 1.3 5.9 8.6 -2.8 -1.1 2.9
Systolic Blood Pressure 1.3 6.3 12.2 -2.4 3.5 -0.9
Smoking Status 0.3 0.8 1.9 -0.7 -1.4 -0.2
Allergy or Eczema 0.3 0.9 1.1 -1.1 -1.0 -0.6
Cardiovascular Disease 1.0 3.3 6.9 -1.3 1.1 -2.6
Hypothyroidism (self reported) 0.1 0.2 0.6 -0.7 -0.0 -0.4
Respiratory disease 0.2 0.4 1.1 -0.2 -1.1 -0.1
Type 2 Diabetes (T2D) (2018) 0.1 0.1 0.2 0.3 0.4 -0.5
Lung FEV1/FVC ratio 1.0 5.0 7.9 -1.5 2.8 -2.2
Lung FVC 0.1 0.6 1.0 0.5 -1.0 0.7
Neuroticism 0.1 0.3 0.9 0.9 0.1 0.3
Chronotype (morning person) 0.9 2.2 2.9 1.7 -1.3 -1.4
Hair Pigment 0.0 0.2 0.2 -0.3 0.5 -0.5
Tanning 0.1 1.8 4.6 2.1 -0.3 0.8
Hand grip strength (left) 0.1 0.3 0.7 -0.3 -0.8 -0.2
Number of treatments/medications taken 0.6 1.1 2.6 -0.7 -0.2 -1.6
Average weekly spirits intake 0.1 0.1 0.2 -0.1 -0.5 -0.0
Sensitivity / hurt feelings 0.3 0.5 1.1 -0.0 -0.7 -1.0
Frequency of depressed mood in last 2 weeks 0.3 0.4 0.6 -0.6 0.4 0.7
Hearing difficulty/problems: Yes 0.7 1.1 2.6 -0.4 -1.6 -0.7
Relative age of first facial hair 0.2 0.4 0.9 0.6 0.0 0.9
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.7 0.1 0.8 0.7
Ever used hormone-replacement therapy (HRT) 1.0 1.3 2.5 1.1 -1.6 0.4
Ever had hysterectomy (womb removed) 0.1 0.1 0.2 0.4 0.2 -0.4
Systolic blood pressure, automated reading 0.5 1.5 2.2 -0.6 1.5 -1.4
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.8 0.1 1.7 -0.7
Angina 2.9 3.7 7.8 -2.8 -0.0 -1.9
Medication for hormone replacement therapy 1.8 2.1 4.2 0.6 -1.3 -2.1
Vitamin and mineral supplements 0.2 0.3 0.5 0.5 0.7 0.2
Supplements: Zinc 0.3 0.4 0.6 -0.1 0.7 0.8
Medication: Co-codamol 0.2 0.3 0.8 -0.1 -0.9 -0.0
Medication: Metformin 0.6 0.9 2.4 0.5 1.6 -0.2
Diabetes (father) 0.2 0.3 0.4 0.6 -0.2 -0.6
Diabetes (mother) 0.7 0.9 0.9 0.9 -1.0 0.9
Severe depression (siblings) 0.3 0.4 0.7 0.6 0.1 0.9
Pack years adult smoking proportion 0.4 0.6 1.5 1.2 0.3 -0.4
Impedance of leg (right) 7.7 37.1 98.4 -9.9 3.5 -0.6
Leg fat-free mass (left) 1.1 6.0 9.4 2.6 -3.1 1.3
Trunk fat percentage 1.2 4.8 8.3 -2.9 -2.5 -0.2
Hand grip strength (right) 0.1 0.2 0.6 -0.0 -0.8 -0.2
Townsend deprivation index at recruitment 1.4 2.0 3.8 1.2 -1.9 0.9
Current tobacco smoking 0.8 1.3 1.9 -0.2 -1.4 -1.4
Average weekly fortified wine intake 0.9 1.0 1.6 -1.2 1.3 0.2
Maternal smoking around birth 0.2 0.3 0.7 0.9 0.4 0.2
Fed-up feelings 0.2 0.3 0.9 0.9 0.2 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.7 -0.4 0.2 0.9
Relative age voice broke 0.3 0.5 1.3 0.3 -0.0 1.1
Taking other prescription medications 0.6 0.9 1.6 -1.3 -0.1 -1.0
Age when periods started (menarche) 0.8 2.0 5.6 -2.4 0.2 -0.6
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.1 0.6 -0.2 1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 1.7 -0.4 -1.0 -1.3
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.5 -0.7 -0.2 0.1
Qualifications: CSEs or equivalent 0.3 0.5 1.3 0.1 0.2 1.2
Serious illness, injury or assault to yourself 1.6 2.0 4.1 -0.2 2.0 1.3
High blood pressure 0.5 1.5 3.6 -0.5 0.9 -1.9
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.2 -0.4 -0.1 -0.3
Multivitamins +/- minerals 0.3 0.3 0.9 1.0 -0.2 0.3
Stomach or abdominal pain in last month 0.6 0.8 0.8 0.9 0.9 -0.8
Supplements: Glucosamine 3.3 4.3 10.8 1.2 -0.7 3.3
Diverticular disease/diverticulitis (self-reported) 1.3 1.5 1.8 -1.3 1.2 -1.2
Medication: Atenolol 0.7 0.9 1.9 0.2 0.9 -1.4
Medication: Levothyroxine sodium 0.2 0.4 0.7 0.6 -0.5 -0.8
Sitting height 0.4 3.0 4.7 -0.1 -2.2 2.1
Chronic bronchitis/emphysema (father) 1.8 2.1 4.3 2.1 0.3 1.4
High blood pressure (mother) 0.1 0.2 0.5 0.0 -0.2 0.7
Body mass index (BMI) 1.5 6.3 12.5 2.5 -3.5 -0.0
Impedance of leg (left) 6.7 32.6 83.7 -9.1 3.7 -0.6
Leg predicted mass (left) 1.2 6.1 9.7 2.6 -3.1 1.3
Trunk fat mass 1.0 4.1 8.4 -1.9 -2.9 0.2
Waist circumference 1.1 4.1 9.9 0.2 -3.1 1.5
Number of incorrect matches in round 0.2 0.3 0.9 0.3 -0.1 -0.9
Past tobacco smoking 0.4 0.7 1.0 0.3 1.0 -1.0
Alcohol usually taken with meals 0.3 0.6 1.2 -0.7 -0.1 -1.1
Nervous feelings 0.1 0.2 0.3 0.0 0.6 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.1 0.5 -1.1 0.5
Hearing difficulty/problems with background noise 1.5 2.3 6.1 0.8 -2.5 0.4
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 -0.2 -0.1 -0.4
Had menopause 1.9 2.4 5.1 0.8 -1.1 -2.3
Had other major operations 1.8 2.2 4.1 0.8 -2.0 1.4
Forced vital capacity (FVC) 1.0 3.9 7.0 -2.6 0.5 2.1
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 1.6 -0.9 -1.1 -1.2
Ever unenthusiastic/disinterested for a whole week 1.2 1.4 3.7 -0.3 1.9 0.7
Qualifications: None of the above 0.2 0.3 0.6 0.4 0.5 -0.8
Financial difficulties in last 2 years 1.3 1.8 4.3 -2.1 -0.0 1.0
Mouth/teeth dental problems 0.4 0.7 1.1 -1.1 0.7 0.7
Heart attack 1.7 2.1 4.6 -1.2 0.5 -2.1
Allergy 0.2 0.5 1.5 1.2 -0.2 -0.1
Pain all over the body in last month 0.4 0.5 0.8 -0.8 -0.9 -0.2
Diabetes (self-reported) 0.5 0.8 1.4 0.1 1.2 -1.0
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 1.6 0.3 -1.2 0.1
Medication: Ramipril 0.3 0.4 0.6 -0.4 -0.7 0.7
Medication: Simvastatin 0.5 0.7 1.8 0.4 -0.0 -1.4
Fluid intelligence score 0.3 0.7 1.4 0.5 1.2 -0.7
Illnesses of siblings 0.3 0.5 1.2 -0.3 -0.3 1.1
Neuroticism score 0.2 0.3 0.6 0.8 -0.6 -0.1
Weight 0.8 4.1 11.2 0.3 -3.4 1.0
Impedance of arm (right) 3.0 14.0 33.6 -5.8 2.9 0.4
Arm fat percentage (right) 0.7 2.9 8.8 -0.1 -3.0 -0.0
Trunk fat-free mass 0.6 3.7 5.0 2.0 -2.2 1.5
Hip circumference 0.5 1.9 5.8 0.2 -2.4 -0.1
Time employed in main current job 0.2 0.2 0.4 0.2 0.6 -0.5
Alcohol intake versus 10 years previously 1.1 1.6 3.3 1.1 -1.8 -0.3
Father’s age at death 0.1 0.1 0.1 0.3 0.2 0.4
Worrier / anxious feelings 0.1 0.1 0.3 0.3 -0.5 -0.3
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.1 4.1 1.5 0.0 2.0
Falls in the last year 1.4 1.9 3.8 -0.2 -1.9 1.4
Hair/balding pattern: Pattern 3 0.2 0.4 0.6 0.3 -0.6 0.8
Number of live births 0.0 0.0 0.1 -0.0 -0.4 0.0
Forced expiratory volume in 1-second (FEV1) 0.8 2.6 5.3 -2.3 1.1 1.1
Pulse rate 1.3 2.2 4.6 0.6 2.1 1.3
Happiness 0.6 0.7 1.2 -1.0 1.1 -0.0
Noisy workplace 0.9 1.1 2.1 -1.5 -0.0 -1.1
Qualifications: A levels/AS levels or equivalent 0.0 0.1 0.2 -0.4 0.0 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.4 -1.2 0.3 0.3
Mouth/teeth dental problems: Dentures 0.6 1.0 2.0 1.4 -0.8 -0.6
Asthma 0.4 0.8 1.2 -0.1 -1.1 1.1
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.6 0.2 0.8 0.8
Medication: Cholesterol lowering 2.3 3.6 7.0 -1.9 0.5 -2.6
Depression (self-reported) 0.0 0.0 0.1 -0.1 -0.3 0.0
Medication: Lansoprazole 0.3 0.3 0.9 0.9 -0.3 -0.0
Prospective memory result 1.0 1.2 1.9 1.4 -1.2 0.4
Lung cancer (father) 1.1 1.3 2.2 0.3 1.5 1.2
Illnesses of mother 0.1 0.2 0.4 0.3 -0.7 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 2.9 -1.7 1.2 1.1
Pulse wave Arterial Stiffness index 1.3 1.5 4.2 2.0 -0.0 0.5
Impedance of arm (left) 3.0 13.8 32.9 -5.7 2.9 -0.2
Arm fat mass (right) 1.0 4.0 11.6 0.5 -3.4 0.3
Trunk predicted mass 0.7 4.0 5.2 2.1 -2.3 1.5
Standing height 0.9 9.3 23.5 -4.8 -0.1 2.1
Length of working week for main job 0.4 0.5 0.7 0.8 -0.8 -0.3
Exposure to tobacco smoke at home 0.5 0.5 1.3 0.1 0.5 -1.2
Breastfed as a baby 0.9 1.1 3.1 -0.2 0.4 -1.8
Tense / ‘highly strung’ 0.7 1.1 1.8 0.7 -0.9 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.0 4.3 0.7 1.2 2.1
Hair/balding pattern: Pattern 4 1.6 3.8 8.6 -0.8 -1.5 -2.9
Birth weight of first child 2.6 4.7 10.2 3.2 -1.3 1.5
Peak expiratory flow (PEF) 0.1 0.2 0.5 -0.7 0.2 0.3
Pulse wave reflection index 3.9 4.8 7.2 2.7 -2.7 -0.0
Ever highly irritable/argumentative for 2 days 0.4 0.4 1.2 -1.1 -0.0 0.3
Loud music exposure frequency 0.7 0.7 1.3 -1.1 -0.9 0.2
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.6 -0.6 -0.8 -0.0
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.2 0.2 0.3 -0.5
Blood clot in the leg (DVT) 1.3 1.6 4.0 -0.6 0.7 -2.0
Medication: Paracetamol 0.8 1.3 3.9 0.1 -0.2 2.0
Headache pain in last month 0.3 0.4 1.0 1.0 -0.4 0.3
Medication for cholesterol, blood pressure or diabetes 3.5 5.9 12.4 2.3 -0.1 3.5
Glaucoma (self-reported) 0.8 0.9 2.4 -0.6 1.5 -0.4
Gout (self-reported) 0.3 0.4 0.4 0.5 0.7 0.6
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.4 0.2 -0.6 -0.6
Medication: Amlodipine 0.1 0.2 0.3 -0.4 -0.1 -0.6
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.0 0.2 0.2 1.0
Birth weight 0.3 0.8 2.2 -0.2 -0.1 1.5
Chronic bronchitis/emphysema (mother) 1.0 1.1 2.9 -0.7 -1.7 -0.2
High blood pressure (siblings) 0.3 0.5 0.7 0.8 0.1 -0.8
Forced vital capacity (FVC), Best measure 0.6 2.2 3.5 -1.9 0.6 1.6
Body fat percentage 1.1 4.5 6.8 -2.6 -2.6 -0.3
Leg fat percentage (right) 1.4 5.1 8.0 -2.7 -2.8 -0.6
Arm fat-free mass (right) 0.7 3.5 5.8 2.0 -2.4 1.0
Exposure to tobacco smoke outside home 1.4 1.8 3.5 0.5 -1.9 -1.3
Comparative body size at age 10 0.3 0.7 0.9 0.6 -0.9 -0.9
Number of full brothers 0.3 0.4 0.7 -0.8 0.4 0.6
Worry too long after embarrassment 0.1 0.1 0.2 0.5 0.4 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 1.7 1.3 0.0 1.0
Wheeze or whistling in the chest in last year 1.6 2.8 6.0 2.4 -0.9 1.3
Number of children fathered 0.5 0.6 0.9 -0.6 -0.9 0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 3.9 -0.8 -0.2 -2.0
Age at first live birth 1.9 3.5 7.2 -2.7 1.5 -1.0
Pulse wave peak to peak time 1.9 2.3 6.5 -2.5 0.3 -0.5
Health satisfaction 0.6 0.8 1.4 1.2 0.3 0.9
Shortness of breath walking on level ground 0.5 0.6 0.7 0.8 0.7 -0.8
Qualifications: College or University degree 0.4 1.3 2.8 1.0 1.7 -0.1
Eye problems/disorders: None of the above 0.6 0.7 1.7 1.3 -0.2 0.7
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.6 -0.6 1.3 -0.2
Emphysema/chronic bronchitis 0.2 0.2 0.4 0.5 0.6 0.0
Medication for pain relief, constipation, heartburn 0.1 0.2 0.3 0.6 0.2 -0.5
Neck or shoulder pain in last month 1.6 2.2 2.9 1.5 -1.2 1.7
Medication: Blood pressure 2.5 4.3 9.1 -2.0 -0.0 -3.0
Angina (self-reported) 3.6 4.7 8.7 -2.9 -0.1 -2.3
Migraine (self-reported) 0.4 0.5 1.3 0.5 -0.0 -1.2
Medication: Ibuprofen 0.3 0.3 0.6 0.5 0.2 0.8
Medication: Allopurinol 1.1 1.4 2.5 1.6 0.7 1.2
Medication: Omeprazole 0.6 0.7 1.8 -1.3 0.6 -0.3
Medication: Seretide 50 evohaler 0.4 0.4 0.5 0.7 -0.5 0.7
Mean time to correctly identify matches 0.1 0.2 0.3 0.2 0.5 0.5
Heart disease (mother) 1.0 1.2 3.6 -0.3 1.9 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 -0.3 -0.4 -0.2
Whole body fat mass 0.9 3.7 9.0 -1.5 -3.0 0.1
Leg fat mass (right) 1.2 4.6 12.4 -1.2 -3.5 -0.1
Arm predicted mass (right) 0.6 3.2 5.9 1.8 -2.4 0.6
Pulse rate, automated reading 1.1 3.7 10.0 -0.3 3.2 1.0
Alcohol intake frequency. 1.2 2.8 7.6 2.8 -0.7 0.5
Comparative height size at age 10 0.7 3.7 5.3 -2.3 0.9 2.2
Number of full sisters 0.5 0.6 1.4 -0.3 -1.2 -0.6
Suffer from ‘nerves’ 0.2 0.3 0.7 0.8 -0.5 0.2
Overall health rating 0.3 0.6 1.0 0.1 1.0 1.0
Chest pain or discomfort 0.2 0.3 0.7 -0.9 0.2 0.4
Had major operations 1.1 1.3 1.9 1.4 1.3 0.6
Age at last live birth 3.9 5.7 8.6 -2.9 1.8 -2.3
Family relationship satisfaction 0.5 0.7 1.7 0.2 1.3 -0.5
Leg pain on walking 0.3 0.4 0.9 0.5 -0.4 0.9
Qualifications: NVQ or HND or HNC or equivalent 3.1 3.8 7.4 0.2 -2.0 2.7
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.0 0.7 -1.0 0.0
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 2.2 1.1 0.2 -1.5
Medication: Aspirin 1.2 1.6 3.1 -1.0 -0.8 -1.8
Supplements: Vitamin C 0.7 0.8 1.9 -1.4 -0.6 -0.5
Knee pain experienced in last month 1.9 2.9 3.9 1.7 -1.4 2.0
Hypertension (Self-reported) 0.7 2.1 5.3 0.0 1.0 -2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.3 -0.6 -0.3 -1.5
Illnesses of father: Heart disease 1.5 2.1 4.7 -2.2 0.4 -1.2
Illnesses of siblings: Diabetes 0.6 0.8 2.0 0.1 0.5 1.4
Smoking status: Previous 0.7 1.1 3.3 -0.1 0.3 1.8
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.6 7.6 -2.8 -0.0 0.5
Whole body fat-free mass 0.8 4.9 6.8 2.4 -2.6 1.3
Leg fat-free mass (right) 1.4 7.3 11.7 3.4 -2.9 1.4
Arm fat percentage (left) 0.7 2.9 8.8 0.1 -3.0 -0.1
Average weekly red wine intake 1.4 2.0 3.2 -1.8 1.2 -1.2
Handedness (chirality/laterality): Left-handed 1.5 1.8 2.7 1.7 0.2 1.6
Mood swings 0.8 1.4 2.1 1.4 -1.5 0.2
Loneliness, isolation 0.5 0.7 1.8 -1.3 -0.4 0.2
Long-standing illness, disability or infirmity 0.2 0.4 1.0 0.3 1.0 -0.2
Ever had bowel cancer screening 0.7 0.8 1.2 1.1 0.8 0.7
Diabetes diagnosed by doctor 0.7 1.1 2.9 0.0 0.6 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 4.4 2.1 0.2 0.7
Friendships satisfaction 0.9 1.1 3.2 0.4 1.8 0.3
Qualifications: nursing, teaching 0.6 1.0 2.2 0.4 -0.8 1.5
Commuting to job workplace: Walk 1.1 1.2 3.2 -0.5 1.8 0.1
Eye problems/disorders: Cataract 0.3 0.4 1.1 -1.1 -0.1 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.4 -1.2 -0.1 -0.7
Medication for cholesterol 0.5 0.7 1.6 -0.6 -0.2 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.5 2.9 4.4 0.7 -2.1 2.0
Back pain experienced in last month 0.8 1.2 2.3 1.5 -0.8 0.9
Mineral and other dietary supplements 0.3 0.4 1.0 0.3 0.1 -1.0
Breast cancer (self-reported) 1.2 1.4 2.9 -1.1 1.7 0.3
Asthma (self-reported) 0.4 0.7 1.7 -0.3 -1.3 0.7
Osteoporosis (self-reported) 0.4 0.4 1.2 0.3 -1.1 0.2
Osteoarthritis (self-reported) 1.5 2.0 5.3 0.7 0.6 2.3
Medication: Aspirin 1.2 1.6 3.5 -0.7 -0.9 -1.9
Medication: Gliclazide 1.2 1.3 3.6 1.9 0.6 0.0
Illnesses of father: None of the above (group 1) 0.7 0.8 1.3 1.1 -1.1 0.1
Smoking status: Current 1.1 1.7 3.0 0.2 -1.7 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.1 0.2 -0.0 0.1 -0.4
Whole body water mass 0.9 5.2 7.0 2.6 -2.6 1.3
Leg predicted mass (right) 1.4 7.5 12.4 3.5 -2.9 1.4
Arm fat mass (left) 1.0 4.0 11.4 0.7 -3.4 0.3
Number of self-reported non-cancer illnesses 0.3 0.5 1.5 0.1 -0.3 -1.2
Average weekly champagne plus white wine intake 0.5 0.7 1.2 -1.1 -0.3 0.9
Miserableness 0.3 0.5 0.7 0.7 -0.8 -0.4
Guilty feelings 0.1 0.2 0.5 0.7 0.1 0.0
Wears glasses or contact lenses 2.0 2.3 6.4 0.7 -2.5 0.2
Ever taken oral contraceptive pill 0.1 0.1 0.1 0.3 -0.3 -0.3
Hearing aid user 0.4 0.5 0.7 -0.7 -0.9 -0.4
Mother’s age at death 0.9 1.2 1.9 -1.3 -1.4 -0.1
Financial situation satisfaction 0.7 0.8 2.2 -1.5 -0.3 0.4
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.2 0.2 -0.4 -0.1
Commuting to job workplace: Public transport 0.3 0.4 1.2 -0.2 1.1 0.1
Eye problems/disorders: Glaucoma 1.7 2.0 5.9 -0.3 2.4 -0.3
Medication: Blood pressure 0.4 0.7 1.0 1.0 0.8 0.6
Pain type(s) experienced in last month: Hip pain 0.4 0.4 0.9 1.0 0.6 -0.3
Supplements: Fish oil (including cod liver oil) 1.0 1.3 1.7 -1.1 1.1 1.3
High cholesterol (Self-reported) 0.2 0.4 0.8 0.6 0.9 -0.3
Medication: Bendroflumethiazide 0.2 0.3 0.7 0.2 0.8 -0.2
Medication: Paracetamol 0.7 1.1 2.8 0.6 -0.4 1.7
Medication: Lisinopril 0.8 1.0 2.5 -0.8 -0.1 -1.6
Medication: Atorvastatin 1.7 2.1 3.7 -1.2 1.9 -1.1
Illnesses of father: High blood pressure 2.4 3.0 7.4 0.4 2.7 1.2
Alcohol drinker status: Never 0.4 0.5 1.2 0.3 -1.1 -0.3
Ever smoked 0.5 0.8 1.8 -0.8 -1.3 -0.2
Basal metabolic rate 0.8 4.3 8.2 1.8 -2.9 1.2
Leg fat percentage (left) 1.1 3.9 7.3 -2.0 -2.7 -0.5
Arm fat-free mass (left) 0.7 3.5 6.6 1.8 -2.6 0.9
Number of operations (self-reported) 0.8 1.3 1.9 1.2 -1.4 0.6
Average weekly beer plus cider intake 1.4 2.0 5.8 0.2 -0.4 2.4
Irritability 0.3 0.6 1.6 -0.0 -1.3 0.3
Risk taking 1.2 1.8 2.8 1.7 0.8 1.4
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 -0.4 0.4 -0.2
Fractured/broken bones in last 5 years 0.5 0.7 1.9 0.1 1.4 0.2
Age started oral contraceptive pill 0.2 0.3 0.7 0.9 0.1 -0.4
Diastolic blood pressure, automated reading 1.9 5.7 10.4 -2.3 3.2 -1.3
Ever depressed for a whole week 0.8 1.0 1.8 0.2 1.4 1.0
Unable to work because of sickness or disability 0.2 0.2 0.4 0.2 0.7 0.5
Commuting to job workplace: Cycle 0.6 0.7 1.4 0.6 -1.2 0.6
Myopia 1.3 1.9 3.7 -1.2 -0.6 -1.9
Vascular/heart problems diagnosed by doctor 1.0 2.8 7.1 0.9 -0.6 2.7
Cholesterol lowering medication 0.3 0.4 0.8 0.9 0.5 0.5
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 1.7 -1.3 1.0 0.1
Pain experienced in last month 2.2 3.6 8.4 -2.9 0.1 -1.6
Supplements: Calcium 0.1 0.1 0.1 -0.3 -0.3 -0.3
Basal cell carcinoma (self-reported) 1.2 1.4 2.4 1.3 -1.6 0.5
Heart attack/myocardial infarction (self-reported) 1.7 2.2 5.4 -1.0 0.5 -2.3
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 2.8 -0.1 0.7 -1.7
Heart disease (siblings) 1.1 1.4 3.9 -0.4 -0.2 -2.0
Alcohol drinker status: Previous 0.7 0.8 1.5 0.8 1.2 0.5
Pack years of smoking 0.6 0.8 2.3 1.5 0.1 -0.3
Impedance of whole body 5.3 26.7 67.4 -8.2 3.5 -0.6
Leg fat mass (left) 1.0 3.9 10.9 -0.8 -3.3 0.1
Arm predicted mass (left) 0.8 4.2 9.7 1.5 -3.1 0.8