[Hub]/) : Traits : Impedance of leg (left) : ← →

chr5:73,626,450-75,704,085

Best TWAS P=1.92e-16 · Best GWAS P=5.29e-18 conditioned to 0.00439

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	POC5	0.17	0.16	lasso	5	0.15	5.2e-18	8.2	-8.2	1.9e-16	-0.90	0.06	0.94	TRUE
17	GTEx	Spleen	CTC-366B18.2	0.16	0.11	lasso	3	0.14	2.2e-04	6.1	7.2	4.7e-13	0.72	0.15	0.46	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	POLK	0.03	0.01	lasso	7	0.02	3.9e-03	5.9	7.0	3.0e-12	0.81	0.27	0.63	FALSE
7	GTEx	Brain Cerebellar Hemisphere	POC5	0.31	0.15	enet	18	0.30	1.6e-08	6.1	6.8	1.4e-11	0.61	0.57	0.28	FALSE
15	GTEx	Spleen	POLK	0.18	-0.01	lasso	16	0.03	5.1e-02	3.2	6.6	5.6e-11	0.59	0.16	0.22	FALSE
22	METSIM	Adipose	POLK	0.05	0.01	enet	16	0.03	4.3e-05	6.8	6.5	7.8e-11	0.58	0.95	0.03	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	POC5	0.04	0.00	enet	7	0.03	2.1e-04	8.2	-6.5	7.8e-11	-0.77	0.02	0.59	FALSE
29	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	POC5	0.24	0.13	blup	70	0.14	1.2e-04	6.0	6.3	3.7e-10	0.73	0.05	0.80	FALSE
10	GTEx	Cells Transformed fibroblasts	POLK	0.06	0.04	lasso	3	0.04	1.0e-03	6.0	-6.2	7.8e-10	-0.61	0.23	0.50	FALSE
16	GTEx	Spleen	POC5	0.42	0.37	lasso	4	0.34	1.3e-09	6.1	6.1	1.0e-09	0.57	0.93	0.04	FALSE
8	GTEx	Brain Hypothalamus	CTC-366B18.4	0.26	0.12	lasso	8	0.07	9.0e-03	6.1	-6.1	1.2e-09	-0.56	0.10	0.09	FALSE
18	GTEx	Testis	POC5	0.27	0.13	lasso	8	0.09	8.1e-05	6.6	-6.1	1.3e-09	-0.65	0.54	0.27	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	ANKDD1B	0.07	0.00	bslmm	382	0.03	7.0e-05	3.3	-6.1	1.4e-09	-0.63	0.08	0.55	FALSE
2	GTEx	Adipose Subcutaneous	POC5	0.08	0.07	lasso	7	0.07	3.2e-06	6.1	6.0	1.8e-09	0.56	0.96	0.00	FALSE
6	GTEx	Brain Cerebellar Hemisphere	POLK	0.27	0.20	lasso	6	0.16	8.3e-05	5.1	6.0	2.2e-09	0.64	0.34	0.17	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	POC5	0.47	0.36	lasso	4	0.39	1.3e-13	6.1	5.9	3.8e-09	0.57	1.00	0.00	FALSE
3	GTEx	Adipose Visceral Omentum	POC5	0.13	0.08	lasso	9	0.08	6.1e-05	5.7	5.9	4.4e-09	0.60	0.82	0.07	FALSE
14	GTEx	Pancreas	POC5	0.32	0.23	lasso	3	0.21	3.5e-09	5.7	5.8	6.1e-09	0.57	1.00	0.00	FALSE
4	GTEx	Adrenal Gland	GCNT4	0.13	0.02	lasso	8	0.01	1.3e-01	5.2	5.8	6.3e-09	0.49	0.07	0.83	FALSE
13	GTEx	Nerve Tibial	POC5	0.16	0.12	lasso	5	0.10	7.6e-08	5.7	5.7	1.4e-08	0.57	0.99	0.00	FALSE
11	GTEx	Cells Transformed fibroblasts	POC5	0.15	0.17	lasso	6	0.16	3.4e-12	5.7	5.7	1.5e-08	0.57	1.00	0.00	FALSE
12	GTEx	Esophagus Mucosa	POC5	0.18	0.16	lasso	1	0.15	4.8e-10	5.7	5.7	1.5e-08	0.57	1.00	0.00	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	POC5	0.05	0.00	blup	384	0.02	8.6e-04	5.7	5.7	1.6e-08	0.57	0.30	0.13	FALSE
27	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HMGCR	0.04	0.02	enet	4	0.03	6.0e-03	5.7	5.6	2.6e-08	0.57	0.02	0.70	FALSE
21	GTEx	Thyroid	CTC-366B18.2	0.06	0.03	lasso	9	0.02	6.2e-03	5.5	5.5	4.0e-08	0.62	0.30	0.18	FALSE
5	GTEx	Artery Tibial	GCNT4	0.08	0.07	lasso	2	0.04	3.9e-04	5.2	-5.3	1.4e-07	-0.44	0.67	0.09	FALSE
20	GTEx	Thyroid	POC5	0.26	0.23	enet	15	0.23	1.8e-17	5.7	5.2	1.7e-07	0.49	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	POLK	0.03	0.01	blup	53	0.01	1.6e-02	3.6	-5.2	2.4e-07	-0.57	0.30	0.45	FALSE
19	GTEx	Testis	GCNT4	0.42	0.35	enet	62	0.37	3.8e-17	4.0	5.1	2.9e-07	0.50	1.00	0.00	FALSE