Hub : Genes

GCNT4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.1320	0.0555	7.2e-04	0.022	NA	0.004	NA	0.010	5.2e-02	NA	2.1e-01	NA	1.3e-01
2	GTEx	Artery Tibial	0.0751	0.0325	1.1e-03	0.070	NA	0.036	NA	0.040	3.6e-06	NA	7.1e-04	NA	3.9e-04
3	GTEx	Muscle Skeletal	0.1324	0.0518	4.5e-03	-0.002	NA	0.004	NA	0.002	6.2e-01	NA	1.1e-01	NA	2.0e-01
4	GTEx	Testis	0.4160	0.0780	5.6e-17	0.354	NA	0.366	NA	0.337	1.5e-16	NA	3.8e-17	NA	1.2e-15
5	TCGA	Colon Adenocarcinoma	0.1030	0.0490	8.2e-04	0.055	0.046	0.048	NA	0.047	4.0e-04	1.2e-03	8.7e-04	NA	1.0e-03
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.1729	0.0858	8.4e-04	-0.002	0.052	0.039	NA	0.002	7.6e-01	1.4e-06	2.9e-05	NA	1.9e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.5	0.7	2.0	0.8	-0.1	0.6	1.4	0.4	-1.2
Bipolar Disorder or Schizophrenia	0.7	1.8	4.6	1.9	-1.2	0.3	2.1	-0.7	-0.5
Depressed Affect (Nagel 2018)	0.5	1.0	2.2	-0.6	0.9	-1.4	-0.2	-0.9	-1.5
Depression (Nagel 2018)	1.0	1.4	4.2	-1.2	2.0	-0.3	-0.4	1.0	-1.4
Intelligence (Savage-Jansen 2018)	0.9	2.9	4.6	2.1	-1.7	-0.4	2.1	-2.0	1.2
Neuroticism (Nagel 2018)	0.7	1.6	3.4	1.5	-1.2	-1.8	1.0	-1.2	-0.1
Schizophrenia (2018)	0.8	1.6	3.3	1.8	-1.5	0.1	1.5	-1.3	0.2
Schizophrenia vs Biploar Disorder	1.5	2.0	6.1	1.1	-1.3	1.3	-0.5	-1.2	2.5
Worry (Nagel 2018)	2.3	4.8	9.4	3.1	-2.8	-1.4	2.3	-1.1	1.6
Alzheimer’s Disease (in mother)	0.2	0.3	0.9	-0.0	0.1	0.9	0.5	0.7	0.2
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.4	-0.2	-0.4	-0.1	-0.3	0.1
Alzheimer’s Disease (including proxy)	0.6	0.9	2.7	1.2	-0.9	0.0	1.6	-0.4	0.1
Crohns Disease (2017)	0.2	0.5	2.1	0.2	-0.5	1.4	0.3	0.3	-0.8
Irritable Bowel Disease (IBD)	0.7	1.6	3.5	-0.4	0.4	1.5	-0.7	1.9	-1.7
Ulcerative Colitis (UC)	1.2	2.3	6.4	-0.7	1.1	1.1	-1.2	2.5	-1.7
Major Depression (MDD)	0.4	0.5	1.2	-0.7	0.5	0.2	-1.1	1.0	-0.2
Reaction Time	0.2	0.4	0.8	-0.9	0.8	-0.4	-0.8	-0.3	0.1
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.4	1.1	-0.9	-1.2	0.2	-1.2	0.8
Breast Cancer	1.0	2.5	4.8	-1.6	1.4	1.8	-2.2	1.6	0.4
Ovarian Cancer	1.2	1.6	4.5	-1.3	0.5	2.1	-1.6	0.3	0.6
Prostate Cancer	0.5	0.7	1.6	-0.5	0.7	1.3	-0.7	0.6	0.9
Age at First Birth	0.7	1.0	4.2	0.7	-0.3	2.1	0.9	-0.2	0.6
Bipolar Disorder (2011)	1.4	1.3	3.9	1.2	-0.8	1.2	2.0	-0.8	0.3
Body Mass Index (BMI) (2010)	3.7	5.0	9.9	-3.1	2.7	0.6	-2.7	2.0	-1.2
Coronary Artery Disease (CAD)	1.1	1.3	4.0	0.7	-1.0	0.7	0.5	-2.0	1.2
Crohns Disease (2012)	0.3	0.6	1.3	0.4	-1.1	0.9	0.3	-0.5	0.8
Mean Putamen Volume	1.0	1.1	2.6	1.3	-1.6	-0.0	0.2	-1.4	0.8
Fasting Glucose	7.9	9.5	16.9	-4.1	3.7	1.8	-4.1	2.5	-0.6
HbA1C	0.1	0.1	0.4	0.1	-0.6	-0.2	0.5	-0.4	-0.1
HDL Cholesterol	0.8	1.3	1.8	1.3	-0.9	-1.0	1.1	-1.1	1.3
LDL Cholesterol	20.6	32.7	56.6	7.0	-4.2	-4.8	7.5	-6.8	1.7
Lupus	0.4	0.6	2.2	-0.7	1.5	0.5	0.1	0.5	0.5
Neuroticism (2016)	1.4	2.0	5.6	1.6	-1.0	-2.4	1.1	-1.2	0.8
Primary Biliary Cirrhosis	0.8	1.1	1.8	-0.8	1.1	1.4	-0.2	1.2	-1.2
Rheumatoid Arthritis	0.4	0.6	1.5	-0.6	0.6	0.9	0.0	1.2	-0.6
Schizophrenia (2014)	1.1	2.5	5.3	2.3	-1.8	-0.7	1.5	-1.7	1.0
Triglycerides	0.1	0.2	0.4	-0.6	0.3	0.6	-0.6	-0.5	0.2
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.8	1.0	-1.3	1.3	0.5	-0.4	0.1
Ulcerative Colitis	1.9	2.8	6.4	-0.4	1.1	1.5	-1.1	2.5	-2.3
Blood Eosinophil Count	0.4	2.7	6.5	-2.1	2.2	-0.4	-2.5	0.8	-0.1
Blood Platelet Count	2.5	29.3	43.3	6.5	-5.7	-3.1	6.2	-6.6	3.2
Blood Red Count	0.0	0.5	2.0	-0.0	-0.2	0.5	-0.7	-0.3	1.4
Blood White Count	0.2	1.5	3.8	-1.9	1.1	-0.4	-1.9	-0.2	0.6
Heel T-Score	0.1	0.9	2.5	-0.5	-0.4	1.0	-1.6	1.2	-0.4
BMI	13.3	77.1	134.6	-11.6	9.6	1.7	-10.9	8.9	-5.8
Height	0.2	4.3	6.2	-2.4	2.5	-0.9	-1.8	2.1	-2.3
Waist Hip Ratio (WHR)	0.3	1.2	4.1	-0.1	-0.2	1.4	-1.0	-0.6	2.0
Systolic Blood Pressure	0.0	0.2	0.6	-0.6	-0.1	-0.7	0.0	-0.8	-0.2
Smoking Status	1.4	3.3	6.3	-2.0	1.7	1.3	-2.5	2.1	-0.5
Allergy or Eczema	0.8	2.2	3.7	-1.6	0.9	1.7	-1.7	0.2	1.9
Cardiovascular Disease	0.7	2.2	5.6	0.9	-0.5	-1.3	2.1	-2.4	-0.5
Hypothyroidism (self reported)	1.5	3.5	8.3	-2.5	1.6	1.3	-2.9	1.5	0.4
Respiratory disease	0.1	0.2	1.0	-0.2	0.2	0.2	-0.6	-0.2	1.0
Type 2 Diabetes (T2D) (2018)	4.8	9.1	15.9	-4.0	3.7	1.7	-3.3	2.7	-2.0
Lung FEV1/FVC ratio	1.2	6.2	11.9	-3.4	3.0	-0.2	-3.5	1.4	-1.6
Lung FVC	0.4	2.1	3.6	1.2	-0.9	1.4	1.1	-1.9	1.8
Neuroticism	1.6	3.8	6.1	2.5	-2.1	-1.8	2.0	-1.9	1.1
Chronotype (morning person)	0.6	1.3	2.8	0.6	-1.7	-0.8	-0.5	-1.2	1.6
Hair Pigment	0.3	8.0	14.5	3.1	-3.8	0.2	2.8	-3.2	2.4
Tanning	0.0	0.4	0.9	0.1	-0.1	0.9	-1.0	0.8	0.5
Hand grip strength (left)	0.6	1.6	4.5	-1.3	2.1	-1.1	0.0	0.8	-1.2
Number of treatments/medications taken	0.4	0.8	3.5	0.3	-0.3	-0.5	0.8	-1.9	-0.2
Average weekly spirits intake	0.4	0.5	1.1	0.7	-0.7	1.0	0.2	0.2	-1.0
Sensitivity / hurt feelings	0.3	0.5	1.2	0.7	-1.0	0.4	-0.0	-1.1	0.2
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.9	-0.8	1.3	0.3	-0.9	0.5	-1.4
Hearing difficulty/problems: Yes	0.2	0.3	1.2	0.3	-0.4	-0.3	-0.0	-1.1	0.3
Relative age of first facial hair	1.4	2.8	5.6	2.4	-1.7	-0.1	1.9	-1.6	1.4
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	2.8	1.4	-1.4	1.7	0.9	-1.2	1.5
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.7	0.7	-0.9	-0.7	0.3	-1.3	0.8
Ever had hysterectomy (womb removed)	0.5	0.6	1.3	0.3	-0.7	1.0	-0.2	-0.8	1.1
Systolic blood pressure, automated reading	0.7	2.0	4.4	-2.1	2.0	0.7	-1.3	0.5	-1.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.8	-0.5	0.9	-1.3	-0.5	0.1	-0.8
Angina	2.1	2.7	4.7	1.9	-1.7	1.4	1.4	-2.2	1.1
Medication for hormone replacement therapy	1.3	1.4	3.1	1.0	-1.7	1.8	0.1	-0.4	1.1
Vitamin and mineral supplements	0.5	0.7	1.8	-0.6	1.1	-0.6	-0.2	1.3	-0.4
Supplements: Zinc	0.5	0.5	1.2	-0.4	0.6	-1.1	0.4	-1.0	-0.4
Medication: Co-codamol	0.9	1.1	2.1	-1.4	0.9	0.4	-1.4	1.1	-0.3
Medication: Metformin	3.0	4.2	6.6	-2.6	2.5	1.4	-2.3	1.7	-1.5
Diabetes (father)	3.6	4.4	8.7	-2.2	1.5	1.9	-3.0	2.5	-0.9
Diabetes (mother)	3.4	4.4	6.8	-2.3	2.6	0.5	-2.5	2.3	-1.5
Severe depression (siblings)	0.8	0.9	2.7	-1.0	0.9	0.4	-1.7	0.8	0.0
Pack years adult smoking proportion	1.3	2.0	3.8	-1.3	1.4	-0.0	-1.2	2.0	-1.8
Impedance of leg (right)	4.8	23.0	38.2	6.2	-5.6	-1.0	5.6	-4.7	3.6
Leg fat-free mass (left)	9.5	50.2	80.1	-8.9	8.0	0.5	-8.1	7.5	-5.8
Trunk fat percentage	8.3	33.2	61.5	-7.8	6.7	1.3	-7.2	5.3	-3.6
Hand grip strength (right)	0.5	1.4	4.3	-1.6	2.1	-0.0	-0.6	1.2	-0.1
Townsend deprivation index at recruitment	0.1	0.2	0.5	-0.7	0.2	0.6	-0.5	-0.3	-0.3
Current tobacco smoking	2.0	3.3	5.5	-1.6	2.0	1.2	-1.7	2.3	-1.9
Average weekly fortified wine intake	0.4	0.4	1.8	0.2	-0.4	-1.3	0.0	-0.7	0.1
Maternal smoking around birth	0.7	1.1	4.0	0.2	-1.2	2.0	-0.7	-0.6	0.2
Fed-up feelings	0.4	0.7	1.9	-1.4	1.1	0.0	-0.5	-0.8	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.0	-1.6	1.7	0.6	-1.7	0.5	-0.4
Relative age voice broke	0.9	1.3	2.3	1.0	-0.9	-1.5	1.1	-0.9	1.5
Taking other prescription medications	0.4	0.5	0.9	-0.9	0.7	-0.6	0.3	-0.9	-0.9
Age when periods started (menarche)	2.2	5.2	9.7	3.1	-2.6	0.7	2.6	-2.6	0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.7	0.6	0.1	-0.4	0.3	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.8	-0.7	0.1	0.2	-1.2	1.4	-1.2
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	5.0	-1.6	1.2	-2.2	-0.8	0.3	-1.7
Qualifications: CSEs or equivalent	0.9	1.2	4.4	0.2	-0.8	2.1	-0.7	-0.4	-1.2
Serious illness, injury or assault to yourself	0.3	0.3	1.0	0.5	-0.1	-0.3	0.7	-0.1	-1.0
High blood pressure	0.3	0.8	2.6	-1.6	1.3	0.1	-0.3	-0.2	0.1
Hayfever, allergic rhinitis or eczema	1.8	3.8	8.2	-2.9	2.4	0.9	-2.6	1.1	0.4
Multivitamins +/- minerals	0.4	0.5	1.8	-0.2	0.2	0.8	-0.7	0.4	-1.3
Stomach or abdominal pain in last month	2.8	3.4	5.8	1.8	-2.0	0.9	1.7	-2.0	2.4
Supplements: Glucosamine	1.0	1.3	4.6	-1.2	1.1	-0.3	-2.1	0.5	-0.2
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	4.5	1.1	-1.1	2.1	1.0	-1.8	1.0
Medication: Atenolol	0.4	0.5	0.6	0.3	-0.7	0.8	0.7	0.7	0.7
Medication: Levothyroxine sodium	0.6	1.1	4.5	-1.2	0.1	0.7	-2.1	0.1	0.1
Sitting height	1.3	9.2	13.8	-3.4	3.5	-1.0	-2.4	3.2	-3.7
Chronic bronchitis/emphysema (father)	1.3	1.6	2.8	-1.7	1.2	1.4	-1.6	0.7	-0.4
High blood pressure (mother)	1.8	2.5	5.1	2.2	-2.3	0.7	1.6	-1.4	0.5
Body mass index (BMI)	11.6	49.4	88.9	-9.4	7.8	1.9	-9.0	6.7	-4.2
Impedance of leg (left)	4.2	20.3	33.8	5.8	-5.3	-0.3	5.1	-4.4	3.7
Leg predicted mass (left)	9.4	49.9	80.3	-9.0	8.0	0.4	-8.1	7.4	-5.8
Trunk fat mass	10.6	45.6	80.8	-9.0	7.7	1.5	-8.3	6.6	-4.3
Waist circumference	11.6	42.4	77.0	-8.8	7.4	2.1	-8.4	6.0	-3.4
Number of incorrect matches in round	0.6	1.0	2.1	1.3	-1.3	-0.2	1.5	-0.7	0.1
Past tobacco smoking	0.3	0.6	1.6	0.7	-0.3	-0.6	1.3	0.1	-1.0
Alcohol usually taken with meals	1.5	2.4	5.9	1.5	-2.4	0.3	1.3	-0.6	2.0
Nervous feelings	1.7	3.2	5.8	2.4	-2.4	-1.1	1.5	-0.9	1.9
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	0.3	-0.3	0.3	-0.1	-0.1	0.4
Hearing difficulty/problems with background noise	0.4	0.6	1.5	-0.3	-0.4	0.5	-1.2	-0.6	1.2
Hair/balding pattern: Pattern 2	0.3	0.4	1.5	-0.5	0.4	-0.1	-1.2	0.5	0.3
Had menopause	1.6	2.0	3.9	1.9	-2.0	-0.9	1.3	-1.1	0.8
Had other major operations	0.2	0.3	0.4	-0.7	0.1	-0.5	-0.5	-0.6	0.6
Forced vital capacity (FVC)	0.0	0.1	0.4	0.0	0.3	0.7	0.3	-0.2	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.0	-0.2	-0.4	0.9	-1.0	0.9	-0.6
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	3.9	-1.5	1.3	2.0	-1.8	1.2	-0.6
Qualifications: None of the above	2.1	4.5	13.0	-2.8	3.6	0.1	-2.1	1.0	-1.1
Financial difficulties in last 2 years	1.9	2.5	8.0	0.9	-1.2	1.3	0.4	-1.8	2.8
Mouth/teeth dental problems	0.5	0.7	2.9	-0.3	0.2	-1.1	0.4	0.0	-1.7
Heart attack	1.0	1.3	4.4	0.8	-1.3	0.3	1.0	-2.1	0.1
Allergy	1.0	2.4	4.9	2.2	-2.0	-0.9	1.8	-0.7	-0.9
Pain all over the body in last month	0.4	0.5	1.3	0.5	-0.3	-0.2	1.1	-1.1	-0.2
Diabetes (self-reported)	6.4	9.8	17.8	-4.2	3.7	1.4	-3.9	2.5	-1.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	3.6	-0.2	-0.1	-0.1	-0.6	0.1	1.9
Medication: Ramipril	0.5	0.6	1.9	-1.1	0.8	1.4	-0.3	-0.2	-0.0
Medication: Simvastatin	2.1	3.2	6.2	2.3	-1.2	-0.6	2.5	-2.2	1.0
Fluid intelligence score	0.7	1.6	2.9	1.7	-1.1	-0.8	1.4	-1.6	0.2
Illnesses of siblings	0.5	0.7	2.9	0.3	-0.4	1.7	0.9	0.4	0.2
Neuroticism score	1.9	3.9	6.4	2.5	-2.3	-1.6	1.7	-2.0	1.4
Weight	11.8	58.0	97.2	-9.9	8.6	1.2	-9.2	7.8	-5.5
Impedance of arm (right)	3.8	17.9	32.0	5.7	-4.6	-2.0	5.3	-3.7	2.9
Arm fat percentage (right)	8.7	34.3	59.6	-7.7	6.4	1.6	-7.7	5.9	-3.2
Trunk fat-free mass	5.9	34.0	49.8	-7.1	6.5	0.7	-6.6	6.7	-4.7
Hip circumference	11.7	50.3	87.2	-9.3	7.8	1.5	-8.8	6.7	-5.3
Time employed in main current job	0.5	0.6	1.6	1.2	-0.3	0.6	0.9	-0.9	0.5
Alcohol intake versus 10 years previously	1.0	1.5	3.2	-1.3	1.2	0.2	-1.8	0.9	-1.3
Father’s age at death	0.8	1.1	2.8	-0.7	1.0	-1.3	-0.4	1.7	-0.6
Worrier / anxious feelings	2.0	3.8	5.9	2.4	-2.3	-2.3	2.0	-1.2	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	4.8	0.6	-0.5	-2.2	0.3	-1.2	-0.1
Falls in the last year	0.9	1.3	5.4	0.8	-0.7	2.3	0.2	0.6	0.7
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	0.4	0.1	0.5	0.8	0.3	-0.2
Number of live births	0.6	0.9	1.8	1.3	-1.0	0.0	0.8	-0.5	1.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.4	-0.5	0.4	0.5	-0.6	-0.2	-0.2
Pulse rate	1.3	2.2	3.6	1.3	-1.3	-1.6	1.4	-1.1	1.9
Happiness	0.5	0.6	1.5	-0.7	0.8	1.2	-0.3	-0.5	-0.9
Noisy workplace	2.5	3.0	6.0	-2.1	2.4	-1.7	-1.4	1.0	-1.4
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.3	1.1	-1.1	0.8	0.3	-1.0	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.8	0.4	-0.6	0.3	-0.4	-0.7	1.4
Mouth/teeth dental problems: Dentures	1.0	1.7	3.6	-1.4	1.9	0.2	-0.9	1.8	-0.9
Asthma	0.4	0.7	1.6	-1.0	1.2	-0.3	-0.2	-0.1	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.6	0.0	-0.4	1.5	-1.6	0.4	0.2
Medication: Cholesterol lowering	4.8	7.5	17.7	2.8	-2.2	-0.7	3.6	-4.2	1.0
Depression (self-reported)	0.9	1.1	1.8	-0.9	1.1	-0.1	-1.2	1.2	-1.3
Medication: Lansoprazole	1.3	1.5	4.1	-0.6	0.6	1.0	-1.0	1.5	-2.0
Prospective memory result	0.6	0.7	2.2	0.1	0.3	-1.5	1.2	-0.1	-0.5
Lung cancer (father)	0.7	0.8	1.2	-1.1	1.1	-0.9	-0.9	0.9	-0.4
Illnesses of mother	0.6	0.7	1.3	-1.1	1.1	0.3	-1.0	0.8	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.0	-0.8	0.9	1.0	-0.7	0.8	-0.6
Pulse wave Arterial Stiffness index	0.4	0.4	1.0	-0.5	0.1	1.0	-0.6	0.9	0.3
Impedance of arm (left)	4.1	19.1	33.3	5.8	-4.6	-1.6	5.5	-4.1	3.1
Arm fat mass (right)	12.2	50.1	86.1	-9.3	7.9	1.7	-8.8	7.2	-4.4
Trunk predicted mass	6.0	34.1	50.0	-7.1	6.5	0.7	-6.7	6.8	-4.7
Standing height	0.6	5.6	10.4	-2.0	2.6	-1.1	-1.3	3.2	-3.2
Length of working week for main job	0.2	0.3	0.6	-0.8	0.1	-0.7	-0.3	-0.3	0.6
Exposure to tobacco smoke at home	2.0	2.3	5.6	-0.7	0.5	2.4	-1.6	1.8	-1.4
Breastfed as a baby	0.5	0.6	2.8	-0.2	-0.4	1.7	0.3	0.2	0.7
Tense / ‘highly strung’	3.7	6.1	11.9	3.5	-3.0	-0.3	3.1	-2.3	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.5	-0.6	0.0	0.5	-1.2	-0.4	0.1
Hair/balding pattern: Pattern 4	1.7	4.0	6.6	2.0	-2.0	-2.0	2.6	-2.2	-0.7
Birth weight of first child	0.7	1.2	2.8	-0.1	0.6	-1.7	1.1	-0.6	-1.6
Peak expiratory flow (PEF)	0.3	0.7	2.2	-1.0	0.6	0.8	-1.5	0.0	-0.4
Pulse wave reflection index	2.4	3.0	4.3	-2.0	1.3	1.6	-2.1	2.0	-1.3
Ever highly irritable/argumentative for 2 days	0.6	0.7	3.0	-0.4	0.1	1.7	-0.9	0.2	-0.2
Loud music exposure frequency	1.2	1.3	4.5	-0.1	0.1	2.1	-1.2	1.0	0.8
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	4.7	1.1	-2.0	0.3	-0.3	-1.3	2.2
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	2.9	1.1	-1.7	0.2	0.5	-1.4	1.5
Blood clot in the leg (DVT)	0.3	0.4	1.5	-0.1	0.7	0.6	-0.2	0.1	1.2
Medication: Paracetamol	0.2	0.3	0.6	0.6	-0.1	-0.5	0.7	-0.8	-0.6
Headache pain in last month	4.6	7.9	12.2	3.5	-3.3	-1.0	2.8	-3.3	2.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	4.0	-0.5	0.0	0.2	-2.0	1.5	0.0
Glaucoma (self-reported)	0.1	0.1	0.3	-0.2	-0.2	-0.4	-0.2	-0.5	0.3
Gout (self-reported)	2.2	3.1	4.9	-1.6	1.9	1.3	-1.2	2.2	-2.0
Hypothyroidism/myxoedema (self-reported)	1.6	3.2	8.9	-2.5	1.5	-0.0	-3.0	1.2	0.0
Medication: Amlodipine	0.6	0.8	1.9	-1.1	1.4	0.7	-0.6	0.3	-0.9
Medication: Ventolin 100micrograms inhaler	3.7	4.8	10.3	-2.5	2.7	-0.2	-1.9	3.2	-1.2
Birth weight	2.9	6.3	11.6	-3.0	3.4	-0.1	-2.3	2.8	-2.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.7	-0.3	-0.2	-1.3	-0.2	-0.9	0.9
High blood pressure (siblings)	0.1	0.2	0.6	-0.4	0.8	-0.6	0.1	-0.1	0.0
Forced vital capacity (FVC), Best measure	0.2	0.6	1.7	0.0	0.7	1.3	0.3	1.0	-0.5
Body fat percentage	9.1	35.8	64.9	-8.1	6.7	1.8	-7.8	5.5	-3.4
Leg fat percentage (right)	7.6	27.5	52.1	-7.0	5.4	2.0	-7.2	4.8	-2.8
Arm fat-free mass (right)	8.3	42.3	68.4	-8.3	7.4	1.3	-7.6	6.9	-4.9
Exposure to tobacco smoke outside home	0.8	1.1	2.5	-1.2	1.1	0.8	-1.6	0.7	0.4
Comparative body size at age 10	3.2	8.8	15.8	-4.0	3.2	1.7	-3.9	2.2	-1.8
Number of full brothers	0.2	0.3	0.9	-0.2	0.2	-0.6	-1.0	-0.4	-0.5
Worry too long after embarrassment	2.8	4.7	9.0	3.0	-2.5	-2.0	2.6	-1.2	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.4	0.4	0.0	1.2	-0.2	1.2	-0.8
Wheeze or whistling in the chest in last year	1.6	2.9	6.4	-2.5	2.0	0.1	-2.5	0.7	0.2
Number of children fathered	0.6	0.6	2.0	-0.9	0.2	1.0	-1.4	-0.1	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.6	0.6	-0.5	1.3	1.3	-0.0	0.5
Age at first live birth	0.8	1.4	4.3	1.2	-0.7	-2.1	0.8	-0.8	-0.8
Pulse wave peak to peak time	0.4	0.5	1.4	0.6	-0.1	-1.2	0.7	-0.7	-0.6
Health satisfaction	0.2	0.2	0.5	-0.6	0.2	-0.3	-0.7	-0.7	-0.0
Shortness of breath walking on level ground	3.1	3.7	8.6	-2.4	1.7	1.4	-2.9	1.4	-0.8
Qualifications: College or University degree	0.4	1.4	3.0	1.6	-1.2	-0.1	1.7	-1.1	0.1
Eye problems/disorders: None of the above	0.3	0.3	0.9	0.9	-0.8	-0.2	0.4	-0.1	0.1
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.2	1.2	-1.0	0.4	1.5	-0.7	0.2
Emphysema/chronic bronchitis	0.2	0.3	0.6	0.3	-0.8	0.2	-0.6	0.7	-0.2
Medication for pain relief, constipation, heartburn	0.5	0.8	1.5	-1.2	0.8	-0.1	-0.6	1.0	1.1
Neck or shoulder pain in last month	0.4	0.5	1.0	0.8	-0.7	0.4	0.7	-0.5	1.0
Medication: Blood pressure	1.0	1.7	3.4	-1.8	1.7	1.4	-0.2	1.4	0.1
Angina (self-reported)	1.8	2.4	4.8	1.7	-1.5	1.3	1.3	-2.2	1.2
Migraine (self-reported)	3.8	4.7	12.7	1.7	-1.7	-0.5	2.0	-2.4	3.6
Medication: Ibuprofen	0.3	0.4	0.7	0.6	-0.8	0.8	-0.4	-0.6	0.6
Medication: Allopurinol	3.3	4.4	6.3	-2.3	2.5	2.2	-1.6	2.1	-1.7
Medication: Omeprazole	1.1	1.3	3.7	-0.7	1.2	-1.3	0.3	-0.7	-1.9
Medication: Seretide 50 evohaler	1.0	1.2	1.8	-0.9	1.3	-1.3	-1.4	0.8	0.4
Mean time to correctly identify matches	0.2	0.4	1.5	0.0	-0.3	0.5	-0.0	-1.2	0.8
Heart disease (mother)	0.4	0.5	1.9	-0.7	0.0	-0.8	-0.2	-1.4	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	5.9	0.6	-1.0	-1.7	1.1	-2.4	-0.4
Whole body fat mass	11.7	48.9	85.3	-9.2	7.9	1.9	-8.7	6.8	-4.4
Leg fat mass (right)	12.6	49.0	84.8	-9.2	7.6	2.1	-9.0	6.9	-4.4
Arm predicted mass (right)	8.3	42.5	68.0	-8.2	7.4	1.2	-7.5	7.0	-5.1
Pulse rate, automated reading	0.4	1.4	5.0	0.7	-0.7	-1.3	0.7	-0.3	2.2
Alcohol intake frequency.	1.6	3.8	6.3	-2.3	2.3	-1.4	-1.6	1.0	-2.5
Comparative height size at age 10	1.1	6.3	14.0	-2.3	2.4	0.8	-2.2	3.7	-2.8
Number of full sisters	0.3	0.4	1.3	0.2	-0.0	1.1	-0.1	0.7	0.7
Suffer from ‘nerves’	1.3	2.0	3.7	1.9	-1.6	-1.1	1.7	-0.3	1.3
Overall health rating	0.4	0.8	3.9	-0.8	0.1	0.4	-2.0	-0.3	0.3
Chest pain or discomfort	0.5	0.7	2.3	-0.4	-0.2	-1.2	-0.4	-1.5	-0.0
Had major operations	0.6	0.8	1.6	1.1	-1.3	1.0	0.4	-0.4	0.7
Age at last live birth	0.5	0.7	1.4	1.2	-1.0	-0.3	0.8	-1.1	-0.5
Family relationship satisfaction	0.6	0.8	4.0	0.0	-0.3	2.0	0.1	-0.4	-0.5
Leg pain on walking	1.6	2.1	4.9	-1.9	1.6	-0.5	-2.2	0.4	-0.8
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	3.9	-1.8	1.9	-1.6	-1.0	2.0	-0.5
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.1	-0.9	0.5	-0.4	-1.0	1.1	-0.3
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	7.5	-1.1	1.6	-1.3	-0.3	1.3	-2.7
Medication: Aspirin	0.4	0.5	1.0	0.5	-0.1	0.8	0.8	-0.8	-1.0
Supplements: Vitamin C	0.6	0.7	3.0	0.0	-0.3	-0.1	0.1	-1.2	1.7
Knee pain experienced in last month	0.2	0.3	1.1	0.1	0.3	-1.1	-0.2	-0.3	0.6
Hypertension (Self-reported)	0.3	0.8	2.5	-1.6	1.4	0.0	-0.2	0.0	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	-0.2	0.1	0.2	0.3	-0.0	-0.3
Illnesses of father: Heart disease	0.8	1.1	3.6	0.2	-0.6	0.3	-0.1	-1.9	1.6
Illnesses of siblings: Diabetes	0.3	0.4	1.5	0.0	0.1	-0.8	0.0	-0.0	-1.2
Smoking status: Previous	0.7	1.1	4.9	-0.3	-0.2	0.1	-0.7	-1.0	2.2
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	6.0	-1.4	1.2	-0.6	-1.3	1.8	-2.4
Whole body fat-free mass	7.7	44.2	68.2	-8.3	7.5	0.7	-7.6	7.4	-5.3
Leg fat-free mass (right)	9.2	49.1	78.0	-8.8	8.0	0.7	-7.9	7.5	-5.7
Arm fat percentage (left)	8.6	34.1	60.5	-7.8	6.4	1.8	-7.6	5.6	-3.3
Average weekly red wine intake	0.3	0.4	0.9	0.6	-0.7	0.6	1.0	-0.3	-0.3
Handedness (chirality/laterality): Left-handed	0.7	0.8	3.7	-0.5	0.3	-1.9	-0.2	-0.9	-0.2
Mood swings	1.0	1.9	3.6	1.1	-0.9	-1.1	1.5	-1.9	-1.4
Loneliness, isolation	0.3	0.3	0.8	-0.8	0.7	0.0	-0.9	-0.2	0.3
Long-standing illness, disability or infirmity	0.7	1.1	2.4	-1.4	0.8	1.1	-1.6	0.3	-0.4
Ever had bowel cancer screening	0.4	0.5	1.0	1.0	-0.8	0.8	0.2	0.6	0.1
Diabetes diagnosed by doctor	5.6	9.2	16.6	-4.1	3.7	2.1	-3.6	2.4	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	3.0	0.6	-0.7	1.7	0.3	0.6	1.2
Friendships satisfaction	1.4	1.7	4.7	1.0	-1.4	1.2	0.9	-2.2	-0.6
Qualifications: nursing, teaching	2.2	3.4	7.0	2.5	-2.6	-0.5	2.3	-1.2	0.5
Commuting to job workplace: Walk	1.3	1.4	4.5	1.0	-0.8	0.4	2.1	-1.4	0.4
Eye problems/disorders: Cataract	0.4	0.5	1.9	-0.0	0.1	0.2	1.4	-0.5	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	6.8	0.2	-0.6	2.6	-0.7	0.3	0.3
Medication for cholesterol	1.3	2.0	6.6	-1.2	1.4	0.2	-1.0	2.6	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	5.9	1.6	-2.4	-0.5	-0.2	-1.4	1.6
Back pain experienced in last month	0.7	1.0	2.8	-0.2	-0.2	1.7	-1.7	0.3	0.4
Mineral and other dietary supplements	0.2	0.3	0.8	-0.5	0.0	0.1	-0.7	0.9	0.1
Breast cancer (self-reported)	0.2	0.3	1.0	0.3	-0.7	-0.0	0.1	-1.0	-0.1
Asthma (self-reported)	0.3	0.6	1.8	-0.8	0.9	-0.4	-0.3	-0.1	1.4
Osteoporosis (self-reported)	2.2	2.7	4.3	0.9	-1.4	2.1	1.3	-2.1	1.8
Osteoarthritis (self-reported)	0.5	0.7	1.6	0.6	-0.7	-0.8	0.1	-1.3	-0.9
Medication: Aspirin	0.7	0.9	1.7	1.0	-0.6	1.0	1.3	-1.0	-0.3
Medication: Gliclazide	0.9	1.0	2.7	-0.6	0.7	0.7	-0.8	1.6	-1.1
Illnesses of father: None of the above (group 1)	1.9	2.3	7.6	2.2	-1.0	-0.5	2.7	-0.4	0.2
Smoking status: Current	2.4	3.9	7.0	-1.6	2.1	1.1	-1.8	2.6	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	1.6	-0.8	0.6	0.5	-1.3	0.2	-0.5
Whole body water mass	7.8	44.6	68.6	-8.3	7.6	0.8	-7.6	7.4	-5.3
Leg predicted mass (right)	9.2	49.2	78.3	-8.8	8.0	0.7	-8.0	7.5	-5.7
Arm fat mass (left)	11.7	47.9	83.7	-9.2	7.8	1.9	-8.6	6.9	-4.3
Number of self-reported non-cancer illnesses	0.2	0.3	1.6	-0.2	0.1	-0.3	-0.0	-1.3	-0.0
Average weekly champagne plus white wine intake	0.7	1.0	2.1	-1.3	0.2	0.5	-1.4	0.3	1.3
Miserableness	1.1	1.9	6.7	1.3	-1.6	-0.6	0.3	-2.6	-0.1
Guilty feelings	0.7	1.0	2.3	1.5	-0.6	-0.9	0.8	-1.0	1.0
Wears glasses or contact lenses	0.7	0.8	2.0	0.7	-0.8	1.1	-0.8	-0.1	1.4
Ever taken oral contraceptive pill	1.2	1.3	4.8	-0.3	0.9	2.2	-0.6	1.2	0.6
Hearing aid user	0.6	0.7	2.2	-0.1	0.6	-1.0	0.8	-0.2	-1.5
Mother’s age at death	0.2	0.2	0.6	0.4	0.0	0.4	0.5	0.1	-0.8
Financial situation satisfaction	0.3	0.3	0.5	-0.7	0.7	-0.5	-0.6	-0.1	-0.7
Tinnitus: Yes, now most or all of the time	0.7	0.9	3.5	-0.1	-0.6	-0.8	-0.5	-1.9	0.7
Commuting to job workplace: Public transport	0.9	1.0	2.0	1.2	-1.0	0.4	1.4	-1.3	0.2
Eye problems/disorders: Glaucoma	0.4	0.4	1.0	0.4	-0.7	0.3	0.3	-0.9	1.0
Medication: Blood pressure	0.2	0.3	0.5	-0.7	0.5	-0.4	-0.7	-0.7	-0.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.1	0.8	-0.9	-0.6	0.6	-1.1	-0.7
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.4	-0.9	1.6	0.2	0.1	0.3	-1.1
High cholesterol (Self-reported)	14.6	25.9	51.3	5.8	-4.1	-2.5	6.4	-7.2	2.4
Medication: Bendroflumethiazide	0.9	1.3	3.4	-1.8	1.6	0.8	-0.3	1.0	-0.4
Medication: Paracetamol	0.3	0.5	1.3	0.9	-0.3	-0.3	0.7	-1.2	-0.0
Medication: Lisinopril	1.3	1.7	4.8	-1.1	1.3	-2.2	-0.7	0.9	-1.1
Medication: Atorvastatin	7.8	9.6	23.7	2.3	-2.0	1.4	3.7	-4.9	3.0
Illnesses of father: High blood pressure	0.3	0.4	0.9	-0.4	0.2	0.9	-0.9	-0.1	-0.5
Alcohol drinker status: Never	1.4	1.6	4.5	1.0	-0.9	-2.1	1.1	-1.4	0.5
Ever smoked	0.3	0.5	1.4	-0.7	0.5	0.8	-1.2	0.4	0.5
Basal metabolic rate	9.2	50.8	79.9	-8.9	8.1	1.0	-8.3	7.8	-5.5
Leg fat percentage (left)	8.4	30.6	56.9	-7.3	5.7	2.3	-7.5	5.0	-3.0
Arm fat-free mass (left)	8.8	44.5	71.6	-8.5	7.6	0.9	-7.7	7.3	-5.0
Number of operations (self-reported)	0.8	1.2	3.1	-0.4	-0.3	1.6	-1.0	-0.6	1.8
Average weekly beer plus cider intake	1.3	1.9	3.7	-1.5	1.9	0.1	-1.9	1.1	-0.9
Irritability	0.5	0.8	1.9	0.9	-0.9	-0.5	0.4	-1.4	0.7
Risk taking	0.2	0.3	1.3	0.1	-0.3	0.2	-1.1	0.5	0.4
Ever had prostate specific antigen (PSA) test	1.5	1.8	3.7	1.9	-1.6	0.0	1.4	-1.3	1.0
Fractured/broken bones in last 5 years	0.5	0.7	2.2	-0.4	0.4	1.5	-0.4	-1.1	0.3
Age started oral contraceptive pill	0.7	0.9	2.6	1.1	-0.6	0.8	1.6	-0.6	0.7
Diastolic blood pressure, automated reading	0.3	0.8	2.5	0.6	-0.7	-0.2	0.5	-1.6	1.1
Ever depressed for a whole week	1.0	1.3	4.4	-0.1	0.4	2.1	-1.4	0.5	0.8
Unable to work because of sickness or disability	0.0	0.1	0.2	0.5	-0.1	-0.3	0.1	-0.0	-0.1
Commuting to job workplace: Cycle	1.0	1.2	2.1	1.3	-1.4	-0.6	1.5	-0.3	-1.1
Myopia	2.6	3.8	6.2	-2.3	1.5	-1.7	-2.5	0.8	-2.3
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.0	1.0	-0.7	-0.5	-0.2	0.7	-0.1
Cholesterol lowering medication	5.1	7.4	15.4	3.3	-1.9	-0.6	3.9	-3.6	1.1
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	3.7	-0.0	0.4	-1.1	0.5	-1.0	-1.9
Pain experienced in last month	2.6	4.3	6.2	-2.3	2.5	-0.4	-1.8	2.4	-2.3
Supplements: Calcium	0.5	0.5	1.0	-0.8	0.7	1.0	-0.6	0.4	-0.6
Basal cell carcinoma (self-reported)	0.3	0.3	0.9	0.3	-0.6	-1.0	-0.1	-0.8	0.2
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.9	0.9	-1.3	0.2	1.1	-2.0	0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.2	0.0	0.6	0.7	-0.1	-0.0	1.1
Heart disease (siblings)	0.3	0.4	0.7	-0.4	0.8	-0.7	-0.4	-0.8	-0.4
Alcohol drinker status: Previous	0.7	0.8	2.2	-0.5	1.5	-0.8	0.1	0.8	-1.0
Pack years of smoking	0.8	1.2	3.1	-0.7	1.0	-0.3	-0.4	1.5	-1.8
Impedance of whole body	5.1	25.9	43.3	6.6	-5.7	-1.4	6.1	-5.1	3.9
Leg fat mass (left)	13.0	50.7	87.6	-9.4	7.7	2.2	-9.1	7.0	-4.4
Arm predicted mass (left)	8.9	45.2	71.2	-8.4	7.6	0.9	-7.7	7.4	-5.3