Hub : Genes

GCNT4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.1320 0.0555 7.2e-04 0.022 NA 0.004 NA 0.010 5.2e-02 NA 2.1e-01 NA 1.3e-01
2 GTEx Artery Tibial 0.0751 0.0325 1.1e-03 0.070 NA 0.036 NA 0.040 3.6e-06 NA 7.1e-04 NA 3.9e-04
3 GTEx Muscle Skeletal 0.1324 0.0518 4.5e-03 -0.002 NA 0.004 NA 0.002 6.2e-01 NA 1.1e-01 NA 2.0e-01
4 GTEx Testis 0.4160 0.0780 5.6e-17 0.354 NA 0.366 NA 0.337 1.5e-16 NA 3.8e-17 NA 1.2e-15
5 TCGA Colon Adenocarcinoma 0.1030 0.0490 8.2e-04 0.055 0.046 0.048 NA 0.047 4.0e-04 1.2e-03 8.7e-04 NA 1.0e-03
6 TCGA Head and Neck Squamous Cell Carcinoma 0.1729 0.0858 8.4e-04 -0.002 0.052 0.039 NA 0.002 7.6e-01 1.4e-06 2.9e-05 NA 1.9e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.5 0.7 2.0 0.8 -0.1 0.6 1.4 0.4 -1.2
Bipolar Disorder or Schizophrenia 0.7 1.8 4.6 1.9 -1.2 0.3 2.1 -0.7 -0.5
Depressed Affect (Nagel 2018) 0.5 1.0 2.2 -0.6 0.9 -1.4 -0.2 -0.9 -1.5
Depression (Nagel 2018) 1.0 1.4 4.2 -1.2 2.0 -0.3 -0.4 1.0 -1.4
Intelligence (Savage-Jansen 2018) 0.9 2.9 4.6 2.1 -1.7 -0.4 2.1 -2.0 1.2
Neuroticism (Nagel 2018) 0.7 1.6 3.4 1.5 -1.2 -1.8 1.0 -1.2 -0.1
Schizophrenia (2018) 0.8 1.6 3.3 1.8 -1.5 0.1 1.5 -1.3 0.2
Schizophrenia vs Biploar Disorder 1.5 2.0 6.1 1.1 -1.3 1.3 -0.5 -1.2 2.5
Worry (Nagel 2018) 2.3 4.8 9.4 3.1 -2.8 -1.4 2.3 -1.1 1.6
Alzheimer’s Disease (in mother) 0.2 0.3 0.9 -0.0 0.1 0.9 0.5 0.7 0.2
Alzheimer’s Disease (in father) 0.1 0.1 0.2 0.4 -0.2 -0.4 -0.1 -0.3 0.1
Alzheimer’s Disease (including proxy) 0.6 0.9 2.7 1.2 -0.9 0.0 1.6 -0.4 0.1
Crohns Disease (2017) 0.2 0.5 2.1 0.2 -0.5 1.4 0.3 0.3 -0.8
Irritable Bowel Disease (IBD) 0.7 1.6 3.5 -0.4 0.4 1.5 -0.7 1.9 -1.7
Ulcerative Colitis (UC) 1.2 2.3 6.4 -0.7 1.1 1.1 -1.2 2.5 -1.7
Major Depression (MDD) 0.4 0.5 1.2 -0.7 0.5 0.2 -1.1 1.0 -0.2
Reaction Time 0.2 0.4 0.8 -0.9 0.8 -0.4 -0.8 -0.3 0.1
Verbal and Numeric Reasoning (VNR) 0.4 0.9 1.4 1.1 -0.9 -1.2 0.2 -1.2 0.8
Breast Cancer 1.0 2.5 4.8 -1.6 1.4 1.8 -2.2 1.6 0.4
Ovarian Cancer 1.2 1.6 4.5 -1.3 0.5 2.1 -1.6 0.3 0.6
Prostate Cancer 0.5 0.7 1.6 -0.5 0.7 1.3 -0.7 0.6 0.9
Age at First Birth 0.7 1.0 4.2 0.7 -0.3 2.1 0.9 -0.2 0.6
Bipolar Disorder (2011) 1.4 1.3 3.9 1.2 -0.8 1.2 2.0 -0.8 0.3
Body Mass Index (BMI) (2010) 3.7 5.0 9.9 -3.1 2.7 0.6 -2.7 2.0 -1.2
Coronary Artery Disease (CAD) 1.1 1.3 4.0 0.7 -1.0 0.7 0.5 -2.0 1.2
Crohns Disease (2012) 0.3 0.6 1.3 0.4 -1.1 0.9 0.3 -0.5 0.8
Mean Putamen Volume 1.0 1.1 2.6 1.3 -1.6 -0.0 0.2 -1.4 0.8
Fasting Glucose 7.9 9.5 16.9 -4.1 3.7 1.8 -4.1 2.5 -0.6
HbA1C 0.1 0.1 0.4 0.1 -0.6 -0.2 0.5 -0.4 -0.1
HDL Cholesterol 0.8 1.3 1.8 1.3 -0.9 -1.0 1.1 -1.1 1.3
LDL Cholesterol 20.6 32.7 56.6 7.0 -4.2 -4.8 7.5 -6.8 1.7
Lupus 0.4 0.6 2.2 -0.7 1.5 0.5 0.1 0.5 0.5
Neuroticism (2016) 1.4 2.0 5.6 1.6 -1.0 -2.4 1.1 -1.2 0.8
Primary Biliary Cirrhosis 0.8 1.1 1.8 -0.8 1.1 1.4 -0.2 1.2 -1.2
Rheumatoid Arthritis 0.4 0.6 1.5 -0.6 0.6 0.9 0.0 1.2 -0.6
Schizophrenia (2014) 1.1 2.5 5.3 2.3 -1.8 -0.7 1.5 -1.7 1.0
Triglycerides 0.1 0.2 0.4 -0.6 0.3 0.6 -0.6 -0.5 0.2
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.8 1.0 -1.3 1.3 0.5 -0.4 0.1
Ulcerative Colitis 1.9 2.8 6.4 -0.4 1.1 1.5 -1.1 2.5 -2.3
Blood Eosinophil Count 0.4 2.7 6.5 -2.1 2.2 -0.4 -2.5 0.8 -0.1
Blood Platelet Count 2.5 29.3 43.3 6.5 -5.7 -3.1 6.2 -6.6 3.2
Blood Red Count 0.0 0.5 2.0 -0.0 -0.2 0.5 -0.7 -0.3 1.4
Blood White Count 0.2 1.5 3.8 -1.9 1.1 -0.4 -1.9 -0.2 0.6
Heel T-Score 0.1 0.9 2.5 -0.5 -0.4 1.0 -1.6 1.2 -0.4
BMI 13.3 77.1 134.6 -11.6 9.6 1.7 -10.9 8.9 -5.8
Height 0.2 4.3 6.2 -2.4 2.5 -0.9 -1.8 2.1 -2.3
Waist Hip Ratio (WHR) 0.3 1.2 4.1 -0.1 -0.2 1.4 -1.0 -0.6 2.0
Systolic Blood Pressure 0.0 0.2 0.6 -0.6 -0.1 -0.7 0.0 -0.8 -0.2
Smoking Status 1.4 3.3 6.3 -2.0 1.7 1.3 -2.5 2.1 -0.5
Allergy or Eczema 0.8 2.2 3.7 -1.6 0.9 1.7 -1.7 0.2 1.9
Cardiovascular Disease 0.7 2.2 5.6 0.9 -0.5 -1.3 2.1 -2.4 -0.5
Hypothyroidism (self reported) 1.5 3.5 8.3 -2.5 1.6 1.3 -2.9 1.5 0.4
Respiratory disease 0.1 0.2 1.0 -0.2 0.2 0.2 -0.6 -0.2 1.0
Type 2 Diabetes (T2D) (2018) 4.8 9.1 15.9 -4.0 3.7 1.7 -3.3 2.7 -2.0
Lung FEV1/FVC ratio 1.2 6.2 11.9 -3.4 3.0 -0.2 -3.5 1.4 -1.6
Lung FVC 0.4 2.1 3.6 1.2 -0.9 1.4 1.1 -1.9 1.8
Neuroticism 1.6 3.8 6.1 2.5 -2.1 -1.8 2.0 -1.9 1.1
Chronotype (morning person) 0.6 1.3 2.8 0.6 -1.7 -0.8 -0.5 -1.2 1.6
Hair Pigment 0.3 8.0 14.5 3.1 -3.8 0.2 2.8 -3.2 2.4
Tanning 0.0 0.4 0.9 0.1 -0.1 0.9 -1.0 0.8 0.5
Hand grip strength (left) 0.6 1.6 4.5 -1.3 2.1 -1.1 0.0 0.8 -1.2
Number of treatments/medications taken 0.4 0.8 3.5 0.3 -0.3 -0.5 0.8 -1.9 -0.2
Average weekly spirits intake 0.4 0.5 1.1 0.7 -0.7 1.0 0.2 0.2 -1.0
Sensitivity / hurt feelings 0.3 0.5 1.2 0.7 -1.0 0.4 -0.0 -1.1 0.2
Frequency of depressed mood in last 2 weeks 0.6 0.9 1.9 -0.8 1.3 0.3 -0.9 0.5 -1.4
Hearing difficulty/problems: Yes 0.2 0.3 1.2 0.3 -0.4 -0.3 -0.0 -1.1 0.3
Relative age of first facial hair 1.4 2.8 5.6 2.4 -1.7 -0.1 1.9 -1.6 1.4
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 2.8 1.4 -1.4 1.7 0.9 -1.2 1.5
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.7 0.7 -0.9 -0.7 0.3 -1.3 0.8
Ever had hysterectomy (womb removed) 0.5 0.6 1.3 0.3 -0.7 1.0 -0.2 -0.8 1.1
Systolic blood pressure, automated reading 0.7 2.0 4.4 -2.1 2.0 0.7 -1.3 0.5 -1.1
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.8 -0.5 0.9 -1.3 -0.5 0.1 -0.8
Angina 2.1 2.7 4.7 1.9 -1.7 1.4 1.4 -2.2 1.1
Medication for hormone replacement therapy 1.3 1.4 3.1 1.0 -1.7 1.8 0.1 -0.4 1.1
Vitamin and mineral supplements 0.5 0.7 1.8 -0.6 1.1 -0.6 -0.2 1.3 -0.4
Supplements: Zinc 0.5 0.5 1.2 -0.4 0.6 -1.1 0.4 -1.0 -0.4
Medication: Co-codamol 0.9 1.1 2.1 -1.4 0.9 0.4 -1.4 1.1 -0.3
Medication: Metformin 3.0 4.2 6.6 -2.6 2.5 1.4 -2.3 1.7 -1.5
Diabetes (father) 3.6 4.4 8.7 -2.2 1.5 1.9 -3.0 2.5 -0.9
Diabetes (mother) 3.4 4.4 6.8 -2.3 2.6 0.5 -2.5 2.3 -1.5
Severe depression (siblings) 0.8 0.9 2.7 -1.0 0.9 0.4 -1.7 0.8 0.0
Pack years adult smoking proportion 1.3 2.0 3.8 -1.3 1.4 -0.0 -1.2 2.0 -1.8
Impedance of leg (right) 4.8 23.0 38.2 6.2 -5.6 -1.0 5.6 -4.7 3.6
Leg fat-free mass (left) 9.5 50.2 80.1 -8.9 8.0 0.5 -8.1 7.5 -5.8
Trunk fat percentage 8.3 33.2 61.5 -7.8 6.7 1.3 -7.2 5.3 -3.6
Hand grip strength (right) 0.5 1.4 4.3 -1.6 2.1 -0.0 -0.6 1.2 -0.1
Townsend deprivation index at recruitment 0.1 0.2 0.5 -0.7 0.2 0.6 -0.5 -0.3 -0.3
Current tobacco smoking 2.0 3.3 5.5 -1.6 2.0 1.2 -1.7 2.3 -1.9
Average weekly fortified wine intake 0.4 0.4 1.8 0.2 -0.4 -1.3 0.0 -0.7 0.1
Maternal smoking around birth 0.7 1.1 4.0 0.2 -1.2 2.0 -0.7 -0.6 0.2
Fed-up feelings 0.4 0.7 1.9 -1.4 1.1 0.0 -0.5 -0.8 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 3.0 -1.6 1.7 0.6 -1.7 0.5 -0.4
Relative age voice broke 0.9 1.3 2.3 1.0 -0.9 -1.5 1.1 -0.9 1.5
Taking other prescription medications 0.4 0.5 0.9 -0.9 0.7 -0.6 0.3 -0.9 -0.9
Age when periods started (menarche) 2.2 5.2 9.7 3.1 -2.6 0.7 2.6 -2.6 0.7
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.5 -0.7 0.6 0.1 -0.4 0.3 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 1.8 -0.7 0.1 0.2 -1.2 1.4 -1.2
Tinnitus: Yes, but not now, but have in the past 2.0 2.1 5.0 -1.6 1.2 -2.2 -0.8 0.3 -1.7
Qualifications: CSEs or equivalent 0.9 1.2 4.4 0.2 -0.8 2.1 -0.7 -0.4 -1.2
Serious illness, injury or assault to yourself 0.3 0.3 1.0 0.5 -0.1 -0.3 0.7 -0.1 -1.0
High blood pressure 0.3 0.8 2.6 -1.6 1.3 0.1 -0.3 -0.2 0.1
Hayfever, allergic rhinitis or eczema 1.8 3.8 8.2 -2.9 2.4 0.9 -2.6 1.1 0.4
Multivitamins +/- minerals 0.4 0.5 1.8 -0.2 0.2 0.8 -0.7 0.4 -1.3
Stomach or abdominal pain in last month 2.8 3.4 5.8 1.8 -2.0 0.9 1.7 -2.0 2.4
Supplements: Glucosamine 1.0 1.3 4.6 -1.2 1.1 -0.3 -2.1 0.5 -0.2
Diverticular disease/diverticulitis (self-reported) 1.7 2.0 4.5 1.1 -1.1 2.1 1.0 -1.8 1.0
Medication: Atenolol 0.4 0.5 0.6 0.3 -0.7 0.8 0.7 0.7 0.7
Medication: Levothyroxine sodium 0.6 1.1 4.5 -1.2 0.1 0.7 -2.1 0.1 0.1
Sitting height 1.3 9.2 13.8 -3.4 3.5 -1.0 -2.4 3.2 -3.7
Chronic bronchitis/emphysema (father) 1.3 1.6 2.8 -1.7 1.2 1.4 -1.6 0.7 -0.4
High blood pressure (mother) 1.8 2.5 5.1 2.2 -2.3 0.7 1.6 -1.4 0.5
Body mass index (BMI) 11.6 49.4 88.9 -9.4 7.8 1.9 -9.0 6.7 -4.2
Impedance of leg (left) 4.2 20.3 33.8 5.8 -5.3 -0.3 5.1 -4.4 3.7
Leg predicted mass (left) 9.4 49.9 80.3 -9.0 8.0 0.4 -8.1 7.4 -5.8
Trunk fat mass 10.6 45.6 80.8 -9.0 7.7 1.5 -8.3 6.6 -4.3
Waist circumference 11.6 42.4 77.0 -8.8 7.4 2.1 -8.4 6.0 -3.4
Number of incorrect matches in round 0.6 1.0 2.1 1.3 -1.3 -0.2 1.5 -0.7 0.1
Past tobacco smoking 0.3 0.6 1.6 0.7 -0.3 -0.6 1.3 0.1 -1.0
Alcohol usually taken with meals 1.5 2.4 5.9 1.5 -2.4 0.3 1.3 -0.6 2.0
Nervous feelings 1.7 3.2 5.8 2.4 -2.4 -1.1 1.5 -0.9 1.9
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.2 0.3 -0.3 0.3 -0.1 -0.1 0.4
Hearing difficulty/problems with background noise 0.4 0.6 1.5 -0.3 -0.4 0.5 -1.2 -0.6 1.2
Hair/balding pattern: Pattern 2 0.3 0.4 1.5 -0.5 0.4 -0.1 -1.2 0.5 0.3
Had menopause 1.6 2.0 3.9 1.9 -2.0 -0.9 1.3 -1.1 0.8
Had other major operations 0.2 0.3 0.4 -0.7 0.1 -0.5 -0.5 -0.6 0.6
Forced vital capacity (FVC) 0.0 0.1 0.4 0.0 0.3 0.7 0.3 -0.2 0.0
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.0 -0.2 -0.4 0.9 -1.0 0.9 -0.6
Ever unenthusiastic/disinterested for a whole week 1.7 2.1 3.9 -1.5 1.3 2.0 -1.8 1.2 -0.6
Qualifications: None of the above 2.1 4.5 13.0 -2.8 3.6 0.1 -2.1 1.0 -1.1
Financial difficulties in last 2 years 1.9 2.5 8.0 0.9 -1.2 1.3 0.4 -1.8 2.8
Mouth/teeth dental problems 0.5 0.7 2.9 -0.3 0.2 -1.1 0.4 0.0 -1.7
Heart attack 1.0 1.3 4.4 0.8 -1.3 0.3 1.0 -2.1 0.1
Allergy 1.0 2.4 4.9 2.2 -2.0 -0.9 1.8 -0.7 -0.9
Pain all over the body in last month 0.4 0.5 1.3 0.5 -0.3 -0.2 1.1 -1.1 -0.2
Diabetes (self-reported) 6.4 9.8 17.8 -4.2 3.7 1.4 -3.9 2.5 -1.9
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 3.6 -0.2 -0.1 -0.1 -0.6 0.1 1.9
Medication: Ramipril 0.5 0.6 1.9 -1.1 0.8 1.4 -0.3 -0.2 -0.0
Medication: Simvastatin 2.1 3.2 6.2 2.3 -1.2 -0.6 2.5 -2.2 1.0
Fluid intelligence score 0.7 1.6 2.9 1.7 -1.1 -0.8 1.4 -1.6 0.2
Illnesses of siblings 0.5 0.7 2.9 0.3 -0.4 1.7 0.9 0.4 0.2
Neuroticism score 1.9 3.9 6.4 2.5 -2.3 -1.6 1.7 -2.0 1.4
Weight 11.8 58.0 97.2 -9.9 8.6 1.2 -9.2 7.8 -5.5
Impedance of arm (right) 3.8 17.9 32.0 5.7 -4.6 -2.0 5.3 -3.7 2.9
Arm fat percentage (right) 8.7 34.3 59.6 -7.7 6.4 1.6 -7.7 5.9 -3.2
Trunk fat-free mass 5.9 34.0 49.8 -7.1 6.5 0.7 -6.6 6.7 -4.7
Hip circumference 11.7 50.3 87.2 -9.3 7.8 1.5 -8.8 6.7 -5.3
Time employed in main current job 0.5 0.6 1.6 1.2 -0.3 0.6 0.9 -0.9 0.5
Alcohol intake versus 10 years previously 1.0 1.5 3.2 -1.3 1.2 0.2 -1.8 0.9 -1.3
Father’s age at death 0.8 1.1 2.8 -0.7 1.0 -1.3 -0.4 1.7 -0.6
Worrier / anxious feelings 2.0 3.8 5.9 2.4 -2.3 -2.3 2.0 -1.2 1.2
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 4.8 0.6 -0.5 -2.2 0.3 -1.2 -0.1
Falls in the last year 0.9 1.3 5.4 0.8 -0.7 2.3 0.2 0.6 0.7
Hair/balding pattern: Pattern 3 0.1 0.2 0.6 0.4 0.1 0.5 0.8 0.3 -0.2
Number of live births 0.6 0.9 1.8 1.3 -1.0 0.0 0.8 -0.5 1.2
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.4 -0.5 0.4 0.5 -0.6 -0.2 -0.2
Pulse rate 1.3 2.2 3.6 1.3 -1.3 -1.6 1.4 -1.1 1.9
Happiness 0.5 0.6 1.5 -0.7 0.8 1.2 -0.3 -0.5 -0.9
Noisy workplace 2.5 3.0 6.0 -2.1 2.4 -1.7 -1.4 1.0 -1.4
Qualifications: A levels/AS levels or equivalent 0.3 0.8 1.3 1.1 -1.1 0.8 0.3 -1.0 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.8 0.4 -0.6 0.3 -0.4 -0.7 1.4
Mouth/teeth dental problems: Dentures 1.0 1.7 3.6 -1.4 1.9 0.2 -0.9 1.8 -0.9
Asthma 0.4 0.7 1.6 -1.0 1.2 -0.3 -0.2 -0.1 1.3
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.6 0.0 -0.4 1.5 -1.6 0.4 0.2
Medication: Cholesterol lowering 4.8 7.5 17.7 2.8 -2.2 -0.7 3.6 -4.2 1.0
Depression (self-reported) 0.9 1.1 1.8 -0.9 1.1 -0.1 -1.2 1.2 -1.3
Medication: Lansoprazole 1.3 1.5 4.1 -0.6 0.6 1.0 -1.0 1.5 -2.0
Prospective memory result 0.6 0.7 2.2 0.1 0.3 -1.5 1.2 -0.1 -0.5
Lung cancer (father) 0.7 0.8 1.2 -1.1 1.1 -0.9 -0.9 0.9 -0.4
Illnesses of mother 0.6 0.7 1.3 -1.1 1.1 0.3 -1.0 0.8 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.0 -0.8 0.9 1.0 -0.7 0.8 -0.6
Pulse wave Arterial Stiffness index 0.4 0.4 1.0 -0.5 0.1 1.0 -0.6 0.9 0.3
Impedance of arm (left) 4.1 19.1 33.3 5.8 -4.6 -1.6 5.5 -4.1 3.1
Arm fat mass (right) 12.2 50.1 86.1 -9.3 7.9 1.7 -8.8 7.2 -4.4
Trunk predicted mass 6.0 34.1 50.0 -7.1 6.5 0.7 -6.7 6.8 -4.7
Standing height 0.6 5.6 10.4 -2.0 2.6 -1.1 -1.3 3.2 -3.2
Length of working week for main job 0.2 0.3 0.6 -0.8 0.1 -0.7 -0.3 -0.3 0.6
Exposure to tobacco smoke at home 2.0 2.3 5.6 -0.7 0.5 2.4 -1.6 1.8 -1.4
Breastfed as a baby 0.5 0.6 2.8 -0.2 -0.4 1.7 0.3 0.2 0.7
Tense / ‘highly strung’ 3.7 6.1 11.9 3.5 -3.0 -0.3 3.1 -2.3 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.5 -0.6 0.0 0.5 -1.2 -0.4 0.1
Hair/balding pattern: Pattern 4 1.7 4.0 6.6 2.0 -2.0 -2.0 2.6 -2.2 -0.7
Birth weight of first child 0.7 1.2 2.8 -0.1 0.6 -1.7 1.1 -0.6 -1.6
Peak expiratory flow (PEF) 0.3 0.7 2.2 -1.0 0.6 0.8 -1.5 0.0 -0.4
Pulse wave reflection index 2.4 3.0 4.3 -2.0 1.3 1.6 -2.1 2.0 -1.3
Ever highly irritable/argumentative for 2 days 0.6 0.7 3.0 -0.4 0.1 1.7 -0.9 0.2 -0.2
Loud music exposure frequency 1.2 1.3 4.5 -0.1 0.1 2.1 -1.2 1.0 0.8
Qualifications: O levels/GCSEs or equivalent 1.2 2.0 4.7 1.1 -2.0 0.3 -0.3 -1.3 2.2
Mouth/teeth dental problems: Bleeding gums 1.1 1.5 2.9 1.1 -1.7 0.2 0.5 -1.4 1.5
Blood clot in the leg (DVT) 0.3 0.4 1.5 -0.1 0.7 0.6 -0.2 0.1 1.2
Medication: Paracetamol 0.2 0.3 0.6 0.6 -0.1 -0.5 0.7 -0.8 -0.6
Headache pain in last month 4.6 7.9 12.2 3.5 -3.3 -1.0 2.8 -3.3 2.0
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 4.0 -0.5 0.0 0.2 -2.0 1.5 0.0
Glaucoma (self-reported) 0.1 0.1 0.3 -0.2 -0.2 -0.4 -0.2 -0.5 0.3
Gout (self-reported) 2.2 3.1 4.9 -1.6 1.9 1.3 -1.2 2.2 -2.0
Hypothyroidism/myxoedema (self-reported) 1.6 3.2 8.9 -2.5 1.5 -0.0 -3.0 1.2 0.0
Medication: Amlodipine 0.6 0.8 1.9 -1.1 1.4 0.7 -0.6 0.3 -0.9
Medication: Ventolin 100micrograms inhaler 3.7 4.8 10.3 -2.5 2.7 -0.2 -1.9 3.2 -1.2
Birth weight 2.9 6.3 11.6 -3.0 3.4 -0.1 -2.3 2.8 -2.0
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.7 -0.3 -0.2 -1.3 -0.2 -0.9 0.9
High blood pressure (siblings) 0.1 0.2 0.6 -0.4 0.8 -0.6 0.1 -0.1 0.0
Forced vital capacity (FVC), Best measure 0.2 0.6 1.7 0.0 0.7 1.3 0.3 1.0 -0.5
Body fat percentage 9.1 35.8 64.9 -8.1 6.7 1.8 -7.8 5.5 -3.4
Leg fat percentage (right) 7.6 27.5 52.1 -7.0 5.4 2.0 -7.2 4.8 -2.8
Arm fat-free mass (right) 8.3 42.3 68.4 -8.3 7.4 1.3 -7.6 6.9 -4.9
Exposure to tobacco smoke outside home 0.8 1.1 2.5 -1.2 1.1 0.8 -1.6 0.7 0.4
Comparative body size at age 10 3.2 8.8 15.8 -4.0 3.2 1.7 -3.9 2.2 -1.8
Number of full brothers 0.2 0.3 0.9 -0.2 0.2 -0.6 -1.0 -0.4 -0.5
Worry too long after embarrassment 2.8 4.7 9.0 3.0 -2.5 -2.0 2.6 -1.2 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.4 0.4 0.0 1.2 -0.2 1.2 -0.8
Wheeze or whistling in the chest in last year 1.6 2.9 6.4 -2.5 2.0 0.1 -2.5 0.7 0.2
Number of children fathered 0.6 0.6 2.0 -0.9 0.2 1.0 -1.4 -0.1 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.6 0.6 -0.5 1.3 1.3 -0.0 0.5
Age at first live birth 0.8 1.4 4.3 1.2 -0.7 -2.1 0.8 -0.8 -0.8
Pulse wave peak to peak time 0.4 0.5 1.4 0.6 -0.1 -1.2 0.7 -0.7 -0.6
Health satisfaction 0.2 0.2 0.5 -0.6 0.2 -0.3 -0.7 -0.7 -0.0
Shortness of breath walking on level ground 3.1 3.7 8.6 -2.4 1.7 1.4 -2.9 1.4 -0.8
Qualifications: College or University degree 0.4 1.4 3.0 1.6 -1.2 -0.1 1.7 -1.1 0.1
Eye problems/disorders: None of the above 0.3 0.3 0.9 0.9 -0.8 -0.2 0.4 -0.1 0.1
Mouth/teeth dental problems: Loose teeth 0.8 0.9 2.2 1.2 -1.0 0.4 1.5 -0.7 0.2
Emphysema/chronic bronchitis 0.2 0.3 0.6 0.3 -0.8 0.2 -0.6 0.7 -0.2
Medication for pain relief, constipation, heartburn 0.5 0.8 1.5 -1.2 0.8 -0.1 -0.6 1.0 1.1
Neck or shoulder pain in last month 0.4 0.5 1.0 0.8 -0.7 0.4 0.7 -0.5 1.0
Medication: Blood pressure 1.0 1.7 3.4 -1.8 1.7 1.4 -0.2 1.4 0.1
Angina (self-reported) 1.8 2.4 4.8 1.7 -1.5 1.3 1.3 -2.2 1.2
Migraine (self-reported) 3.8 4.7 12.7 1.7 -1.7 -0.5 2.0 -2.4 3.6
Medication: Ibuprofen 0.3 0.4 0.7 0.6 -0.8 0.8 -0.4 -0.6 0.6
Medication: Allopurinol 3.3 4.4 6.3 -2.3 2.5 2.2 -1.6 2.1 -1.7
Medication: Omeprazole 1.1 1.3 3.7 -0.7 1.2 -1.3 0.3 -0.7 -1.9
Medication: Seretide 50 evohaler 1.0 1.2 1.8 -0.9 1.3 -1.3 -1.4 0.8 0.4
Mean time to correctly identify matches 0.2 0.4 1.5 0.0 -0.3 0.5 -0.0 -1.2 0.8
Heart disease (mother) 0.4 0.5 1.9 -0.7 0.0 -0.8 -0.2 -1.4 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 5.9 0.6 -1.0 -1.7 1.1 -2.4 -0.4
Whole body fat mass 11.7 48.9 85.3 -9.2 7.9 1.9 -8.7 6.8 -4.4
Leg fat mass (right) 12.6 49.0 84.8 -9.2 7.6 2.1 -9.0 6.9 -4.4
Arm predicted mass (right) 8.3 42.5 68.0 -8.2 7.4 1.2 -7.5 7.0 -5.1
Pulse rate, automated reading 0.4 1.4 5.0 0.7 -0.7 -1.3 0.7 -0.3 2.2
Alcohol intake frequency. 1.6 3.8 6.3 -2.3 2.3 -1.4 -1.6 1.0 -2.5
Comparative height size at age 10 1.1 6.3 14.0 -2.3 2.4 0.8 -2.2 3.7 -2.8
Number of full sisters 0.3 0.4 1.3 0.2 -0.0 1.1 -0.1 0.7 0.7
Suffer from ‘nerves’ 1.3 2.0 3.7 1.9 -1.6 -1.1 1.7 -0.3 1.3
Overall health rating 0.4 0.8 3.9 -0.8 0.1 0.4 -2.0 -0.3 0.3
Chest pain or discomfort 0.5 0.7 2.3 -0.4 -0.2 -1.2 -0.4 -1.5 -0.0
Had major operations 0.6 0.8 1.6 1.1 -1.3 1.0 0.4 -0.4 0.7
Age at last live birth 0.5 0.7 1.4 1.2 -1.0 -0.3 0.8 -1.1 -0.5
Family relationship satisfaction 0.6 0.8 4.0 0.0 -0.3 2.0 0.1 -0.4 -0.5
Leg pain on walking 1.6 2.1 4.9 -1.9 1.6 -0.5 -2.2 0.4 -0.8
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.4 3.9 -1.8 1.9 -1.6 -1.0 2.0 -0.5
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.1 -0.9 0.5 -0.4 -1.0 1.1 -0.3
Illness, injury, bereavement, stress in last 2 years 2.0 2.5 7.5 -1.1 1.6 -1.3 -0.3 1.3 -2.7
Medication: Aspirin 0.4 0.5 1.0 0.5 -0.1 0.8 0.8 -0.8 -1.0
Supplements: Vitamin C 0.6 0.7 3.0 0.0 -0.3 -0.1 0.1 -1.2 1.7
Knee pain experienced in last month 0.2 0.3 1.1 0.1 0.3 -1.1 -0.2 -0.3 0.6
Hypertension (Self-reported) 0.3 0.8 2.5 -1.6 1.4 0.0 -0.2 0.0 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.0 0.1 -0.2 0.1 0.2 0.3 -0.0 -0.3
Illnesses of father: Heart disease 0.8 1.1 3.6 0.2 -0.6 0.3 -0.1 -1.9 1.6
Illnesses of siblings: Diabetes 0.3 0.4 1.5 0.0 0.1 -0.8 0.0 -0.0 -1.2
Smoking status: Previous 0.7 1.1 4.9 -0.3 -0.2 0.1 -0.7 -1.0 2.2
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.4 6.0 -1.4 1.2 -0.6 -1.3 1.8 -2.4
Whole body fat-free mass 7.7 44.2 68.2 -8.3 7.5 0.7 -7.6 7.4 -5.3
Leg fat-free mass (right) 9.2 49.1 78.0 -8.8 8.0 0.7 -7.9 7.5 -5.7
Arm fat percentage (left) 8.6 34.1 60.5 -7.8 6.4 1.8 -7.6 5.6 -3.3
Average weekly red wine intake 0.3 0.4 0.9 0.6 -0.7 0.6 1.0 -0.3 -0.3
Handedness (chirality/laterality): Left-handed 0.7 0.8 3.7 -0.5 0.3 -1.9 -0.2 -0.9 -0.2
Mood swings 1.0 1.9 3.6 1.1 -0.9 -1.1 1.5 -1.9 -1.4
Loneliness, isolation 0.3 0.3 0.8 -0.8 0.7 0.0 -0.9 -0.2 0.3
Long-standing illness, disability or infirmity 0.7 1.1 2.4 -1.4 0.8 1.1 -1.6 0.3 -0.4
Ever had bowel cancer screening 0.4 0.5 1.0 1.0 -0.8 0.8 0.2 0.6 0.1
Diabetes diagnosed by doctor 5.6 9.2 16.6 -4.1 3.7 2.1 -3.6 2.4 -1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 3.0 0.6 -0.7 1.7 0.3 0.6 1.2
Friendships satisfaction 1.4 1.7 4.7 1.0 -1.4 1.2 0.9 -2.2 -0.6
Qualifications: nursing, teaching 2.2 3.4 7.0 2.5 -2.6 -0.5 2.3 -1.2 0.5
Commuting to job workplace: Walk 1.3 1.4 4.5 1.0 -0.8 0.4 2.1 -1.4 0.4
Eye problems/disorders: Cataract 0.4 0.5 1.9 -0.0 0.1 0.2 1.4 -0.5 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 6.8 0.2 -0.6 2.6 -0.7 0.3 0.3
Medication for cholesterol 1.3 2.0 6.6 -1.2 1.4 0.2 -1.0 2.6 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.2 5.9 1.6 -2.4 -0.5 -0.2 -1.4 1.6
Back pain experienced in last month 0.7 1.0 2.8 -0.2 -0.2 1.7 -1.7 0.3 0.4
Mineral and other dietary supplements 0.2 0.3 0.8 -0.5 0.0 0.1 -0.7 0.9 0.1
Breast cancer (self-reported) 0.2 0.3 1.0 0.3 -0.7 -0.0 0.1 -1.0 -0.1
Asthma (self-reported) 0.3 0.6 1.8 -0.8 0.9 -0.4 -0.3 -0.1 1.4
Osteoporosis (self-reported) 2.2 2.7 4.3 0.9 -1.4 2.1 1.3 -2.1 1.8
Osteoarthritis (self-reported) 0.5 0.7 1.6 0.6 -0.7 -0.8 0.1 -1.3 -0.9
Medication: Aspirin 0.7 0.9 1.7 1.0 -0.6 1.0 1.3 -1.0 -0.3
Medication: Gliclazide 0.9 1.0 2.7 -0.6 0.7 0.7 -0.8 1.6 -1.1
Illnesses of father: None of the above (group 1) 1.9 2.3 7.6 2.2 -1.0 -0.5 2.7 -0.4 0.2
Smoking status: Current 2.4 3.9 7.0 -1.6 2.1 1.1 -1.8 2.6 -2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.5 1.6 -0.8 0.6 0.5 -1.3 0.2 -0.5
Whole body water mass 7.8 44.6 68.6 -8.3 7.6 0.8 -7.6 7.4 -5.3
Leg predicted mass (right) 9.2 49.2 78.3 -8.8 8.0 0.7 -8.0 7.5 -5.7
Arm fat mass (left) 11.7 47.9 83.7 -9.2 7.8 1.9 -8.6 6.9 -4.3
Number of self-reported non-cancer illnesses 0.2 0.3 1.6 -0.2 0.1 -0.3 -0.0 -1.3 -0.0
Average weekly champagne plus white wine intake 0.7 1.0 2.1 -1.3 0.2 0.5 -1.4 0.3 1.3
Miserableness 1.1 1.9 6.7 1.3 -1.6 -0.6 0.3 -2.6 -0.1
Guilty feelings 0.7 1.0 2.3 1.5 -0.6 -0.9 0.8 -1.0 1.0
Wears glasses or contact lenses 0.7 0.8 2.0 0.7 -0.8 1.1 -0.8 -0.1 1.4
Ever taken oral contraceptive pill 1.2 1.3 4.8 -0.3 0.9 2.2 -0.6 1.2 0.6
Hearing aid user 0.6 0.7 2.2 -0.1 0.6 -1.0 0.8 -0.2 -1.5
Mother’s age at death 0.2 0.2 0.6 0.4 0.0 0.4 0.5 0.1 -0.8
Financial situation satisfaction 0.3 0.3 0.5 -0.7 0.7 -0.5 -0.6 -0.1 -0.7
Tinnitus: Yes, now most or all of the time 0.7 0.9 3.5 -0.1 -0.6 -0.8 -0.5 -1.9 0.7
Commuting to job workplace: Public transport 0.9 1.0 2.0 1.2 -1.0 0.4 1.4 -1.3 0.2
Eye problems/disorders: Glaucoma 0.4 0.4 1.0 0.4 -0.7 0.3 0.3 -0.9 1.0
Medication: Blood pressure 0.2 0.3 0.5 -0.7 0.5 -0.4 -0.7 -0.7 -0.1
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.1 0.8 -0.9 -0.6 0.6 -1.1 -0.7
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.4 -0.9 1.6 0.2 0.1 0.3 -1.1
High cholesterol (Self-reported) 14.6 25.9 51.3 5.8 -4.1 -2.5 6.4 -7.2 2.4
Medication: Bendroflumethiazide 0.9 1.3 3.4 -1.8 1.6 0.8 -0.3 1.0 -0.4
Medication: Paracetamol 0.3 0.5 1.3 0.9 -0.3 -0.3 0.7 -1.2 -0.0
Medication: Lisinopril 1.3 1.7 4.8 -1.1 1.3 -2.2 -0.7 0.9 -1.1
Medication: Atorvastatin 7.8 9.6 23.7 2.3 -2.0 1.4 3.7 -4.9 3.0
Illnesses of father: High blood pressure 0.3 0.4 0.9 -0.4 0.2 0.9 -0.9 -0.1 -0.5
Alcohol drinker status: Never 1.4 1.6 4.5 1.0 -0.9 -2.1 1.1 -1.4 0.5
Ever smoked 0.3 0.5 1.4 -0.7 0.5 0.8 -1.2 0.4 0.5
Basal metabolic rate 9.2 50.8 79.9 -8.9 8.1 1.0 -8.3 7.8 -5.5
Leg fat percentage (left) 8.4 30.6 56.9 -7.3 5.7 2.3 -7.5 5.0 -3.0
Arm fat-free mass (left) 8.8 44.5 71.6 -8.5 7.6 0.9 -7.7 7.3 -5.0
Number of operations (self-reported) 0.8 1.2 3.1 -0.4 -0.3 1.6 -1.0 -0.6 1.8
Average weekly beer plus cider intake 1.3 1.9 3.7 -1.5 1.9 0.1 -1.9 1.1 -0.9
Irritability 0.5 0.8 1.9 0.9 -0.9 -0.5 0.4 -1.4 0.7
Risk taking 0.2 0.3 1.3 0.1 -0.3 0.2 -1.1 0.5 0.4
Ever had prostate specific antigen (PSA) test 1.5 1.8 3.7 1.9 -1.6 0.0 1.4 -1.3 1.0
Fractured/broken bones in last 5 years 0.5 0.7 2.2 -0.4 0.4 1.5 -0.4 -1.1 0.3
Age started oral contraceptive pill 0.7 0.9 2.6 1.1 -0.6 0.8 1.6 -0.6 0.7
Diastolic blood pressure, automated reading 0.3 0.8 2.5 0.6 -0.7 -0.2 0.5 -1.6 1.1
Ever depressed for a whole week 1.0 1.3 4.4 -0.1 0.4 2.1 -1.4 0.5 0.8
Unable to work because of sickness or disability 0.0 0.1 0.2 0.5 -0.1 -0.3 0.1 -0.0 -0.1
Commuting to job workplace: Cycle 1.0 1.2 2.1 1.3 -1.4 -0.6 1.5 -0.3 -1.1
Myopia 2.6 3.8 6.2 -2.3 1.5 -1.7 -2.5 0.8 -2.3
Vascular/heart problems diagnosed by doctor 0.1 0.4 1.0 1.0 -0.7 -0.5 -0.2 0.7 -0.1
Cholesterol lowering medication 5.1 7.4 15.4 3.3 -1.9 -0.6 3.9 -3.6 1.1
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 3.7 -0.0 0.4 -1.1 0.5 -1.0 -1.9
Pain experienced in last month 2.6 4.3 6.2 -2.3 2.5 -0.4 -1.8 2.4 -2.3
Supplements: Calcium 0.5 0.5 1.0 -0.8 0.7 1.0 -0.6 0.4 -0.6
Basal cell carcinoma (self-reported) 0.3 0.3 0.9 0.3 -0.6 -1.0 -0.1 -0.8 0.2
Heart attack/myocardial infarction (self-reported) 1.0 1.3 3.9 0.9 -1.3 0.2 1.1 -2.0 0.2
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 1.2 0.0 0.6 0.7 -0.1 -0.0 1.1
Heart disease (siblings) 0.3 0.4 0.7 -0.4 0.8 -0.7 -0.4 -0.8 -0.4
Alcohol drinker status: Previous 0.7 0.8 2.2 -0.5 1.5 -0.8 0.1 0.8 -1.0
Pack years of smoking 0.8 1.2 3.1 -0.7 1.0 -0.3 -0.4 1.5 -1.8
Impedance of whole body 5.1 25.9 43.3 6.6 -5.7 -1.4 6.1 -5.1 3.9
Leg fat mass (left) 13.0 50.7 87.6 -9.4 7.7 2.2 -9.1 7.0 -4.4
Arm predicted mass (left) 8.9 45.2 71.2 -8.4 7.6 0.9 -7.7 7.4 -5.3