TWAS hub - ANKDD1B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0767	0.0265	2.9e-05	0.008	0.028	0.028	0.030	0.022	0.016	4.6e-05	3.7e-05	2e-05	0.00027
2	ROSMAP	Brain Pre-frontal Cortex	0.0676	0.0316	2.1e-04	-0.002	0.028	0.008	0.031	-0.002	0.790	1.4e-04	3.0e-02	7e-05	0.90000

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
LDL Cholesterol	22.6	35.8	54.3	-4.2	-7.4
BMI	13.3	76.9	134.6	4.4	11.6
High cholesterol (Self-reported)	13.2	23.4	42.0	-2.2	-6.5
Leg fat mass (right)	12.1	46.8	75.5	4.3	8.7
Leg fat mass (left)	12.1	47.4	77.1	4.2	8.8
Body mass index (BMI)	11.8	50.2	76.7	4.9	8.8
Waist circumference	11.4	41.7	67.7	4.0	8.2
Arm fat mass (right)	11.1	45.7	76.9	3.8	8.8
Weight	11.0	54.1	89.9	4.3	9.5
Arm fat mass (left)	11.0	45.1	73.8	4.0	8.6
Whole body fat mass	10.8	45.1	75.5	3.8	8.7
Hip circumference	10.5	45.3	70.2	4.5	8.4
Trunk fat mass	9.6	41.0	68.7	3.6	8.3
Medication: Atorvastatin	8.7	10.7	20.6	0.9	-4.5
Leg fat percentage (left)	8.4	30.4	44.1	4.1	6.6
Leg fat-free mass (left)	8.2	43.7	77.3	3.2	8.8
Leg predicted mass (left)	8.2	43.7	76.9	3.2	8.8
Arm fat percentage (left)	8.2	32.6	55.0	3.2	7.4
Body fat percentage	8.1	31.9	52.4	3.4	7.2
Arm fat percentage (right)	8.0	31.6	55.2	2.8	7.4
Leg fat percentage (right)	7.9	28.7	41.6	4.0	6.5
Basal metabolic rate	7.8	43.1	75.9	3.2	8.7
Leg fat-free mass (right)	7.6	40.4	70.6	3.2	8.4
Leg predicted mass (right)	7.6	40.8	71.4	3.2	8.4
Arm fat-free mass (left)	7.6	38.3	64.2	3.5	8.0
Arm fat-free mass (right)	7.3	37.2	63.0	3.4	7.9
Arm predicted mass (left)	7.3	37.3	64.5	3.2	8.0
Trunk fat percentage	7.2	28.9	47.7	3.2	6.9
Arm predicted mass (right)	7.1	36.5	62.8	3.2	7.9
Body Mass Index (BMI) (2010)	6.7	9.2	14.1	2.1	3.8
Whole body water mass	6.6	37.9	67.9	2.8	8.2
Whole body fat-free mass	6.5	37.3	66.6	2.8	8.2
Medication: Lansoprazole	6.0	6.8	13.2	0.6	3.6
Comparative body size at age 10	5.7	15.6	22.7	2.9	4.8
Impedance of whole body	5.4	27.5	42.6	-3.5	-6.5
Diabetes (self-reported)	5.2	8.0	11.3	2.2	3.4
Type 2 Diabetes (T2D) (2018)	5.1	9.5	18.5	0.8	4.3
Trunk fat-free mass	5.0	28.6	52.0	2.3	7.2
Trunk predicted mass	5.0	28.7	52.3	2.3	7.2
Impedance of leg (right)	4.8	23.4	37.0	-3.1	-6.1
Impedance of leg (left)	4.8	23.2	36.7	-3.1	-6.1
Diabetes diagnosed by doctor	4.8	7.9	14.1	1.3	3.8
Impedance of arm (right)	4.7	21.8	29.0	-3.8	-5.4
Shortness of breath walking on level ground	4.7	5.6	11.2	3.4	-0.1
Impedance of arm (left)	4.6	21.1	30.2	-3.5	-5.5
Heart disease (mother)	4.6	5.6	11.1	3.3	-0.2
Migraine (self-reported)	4.5	5.5	10.5	-0.7	-3.2
Medication: Cholesterol lowering	4.1	6.4	12.7	-0.3	-3.6
Headache pain in last month	4.1	7.0	13.9	-0.4	-3.7
Miserableness	4.0	7.0	8.8	2.3	-3.0
Medication: Metformin	3.9	5.5	9.3	1.3	3.0
Gout (self-reported)	3.8	5.2	10.4	0.1	3.2
Pulse rate	3.6	6.1	11.2	-1.0	-3.4
Medication: Allopurinol	3.6	4.8	9.7	0.2	3.1
Cholesterol lowering medication	3.5	5.1	9.2	-1.0	-3.0
Tense / ‘highly strung’	3.3	5.4	10.3	-0.7	-3.2
Pulse wave reflection index	3.1	3.8	7.0	0.8	2.6
Health satisfaction	3.1	4.1	7.1	2.7	-1.1
Diabetes (mother)	3.0	3.8	4.8	1.6	2.2
Blood Platelet Count	2.9	34.1	57.0	-3.3	-7.5
Relative age of first facial hair	2.9	6.0	6.1	-2.4	-2.5
Worry too long after embarrassment	2.7	4.6	7.4	-1.3	-2.7
Medication: Gliclazide	2.7	3.0	5.7	-0.6	2.4
Exposure to tobacco smoke at home	2.6	2.9	4.0	-1.3	2.0
Fasting Glucose	2.4	2.9	4.3	-1.2	2.1
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.5	7.8	2.8	1.8
Financial difficulties in last 2 years	2.4	3.2	3.7	1.9	-1.6
Medication: Ventolin 100micrograms inhaler	2.4	3.0	5.7	0.6	2.4
Comparative height size at age 10	2.4	13.1	24.6	-1.2	5.0
Ulcerative Colitis (UC)	2.2	4.1	7.3	-1.0	2.7
Ovarian Cancer	2.2	2.9	5.2	2.3	0.8
Mean Putamen Volume	2.2	2.6	4.7	2.2	-0.6
Frequency of depressed mood in last 2 weeks	2.2	3.1	3.3	1.7	-1.8
Age when periods started (menarche)	2.2	5.4	10.6	-0.3	-3.3
Mouth/teeth dental problems: Bleeding gums	2.2	2.8	5.5	0.3	-2.4
Ever taken oral contraceptive pill	2.2	2.4	4.4	-2.1	0.7
Alcohol intake versus 10 years previously	2.1	3.1	5.8	0.6	2.4
Mouth/teeth dental problems: Dentures	2.1	3.5	4.4	-2.1	1.6
Wheeze or whistling in the chest in last year	2.1	3.8	4.4	2.1	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	4.9	2.2	-0.2
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.6	4.8	-0.6	2.2
Long-standing illness, disability or infirmity	2.1	3.2	3.4	1.9	1.7
Diastolic blood pressure, automated reading	2.1	6.5	13.0	-0.0	-3.6
Worry (Nagel 2018)	2.0	4.2	5.9	-2.4	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.4	5.3	2.3	1.9
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	3.8	-2.0	0.7
Hair/balding pattern: Pattern 3	1.9	2.8	5.6	-2.4	0.1
Tinnitus: Yes, now most or all of the time	1.9	2.2	4.1	2.0	-0.5
Rheumatoid Arthritis	1.8	2.4	3.0	1.4	1.7
Neuroticism score	1.8	3.7	7.4	-0.1	-2.7
Pain experienced in last month	1.8	3.1	5.2	-0.9	2.3
Schizophrenia vs Biploar Disorder	1.7	2.3	4.4	-0.3	-2.1
Time employed in main current job	1.7	2.0	3.4	-0.7	-1.9
High blood pressure (siblings)	1.7	2.5	4.1	-1.0	2.0
Mood swings	1.7	3.1	6.2	-0.0	-2.5
Myopia	1.7	2.5	4.4	0.7	2.1
Neuroticism	1.6	3.9	5.9	-1.4	-2.4
Chronic bronchitis/emphysema (father)	1.6	1.8	3.5	1.9	0.4
Had other major operations	1.6	2.0	2.4	1.6	1.2
Chronic bronchitis/emphysema (mother)	1.6	1.9	3.6	1.9	-0.3
Average weekly beer plus cider intake	1.6	2.4	3.1	1.8	1.2
Maternal smoking around birth	1.5	2.2	4.2	0.3	2.0
Medication: Simvastatin	1.5	2.2	2.8	-1.3	-1.7
Ever highly irritable/argumentative for 2 days	1.5	1.9	2.7	1.0	1.6
Pulse rate, automated reading	1.5	4.9	8.8	-1.0	-3.0
Ever had bowel cancer screening	1.5	1.7	1.9	-1.4	1.2
Irritability	1.5	2.5	4.8	-0.4	-2.2
Supplements: Calcium	1.5	1.6	2.7	-1.6	0.7
Age at First Birth	1.4	2.0	2.4	-1.5	1.3
Schizophrenia (2014)	1.4	3.0	5.3	-0.8	-2.3
Ulcerative Colitis	1.4	2.0	3.0	-1.0	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	3.7	1.9	0.2
Number of children fathered	1.4	1.5	2.2	1.5	0.9
Friendships satisfaction	1.4	1.7	2.9	0.7	-1.7
HDL Cholesterol	1.3	2.2	2.4	-1.4	-1.5
Smoking Status	1.3	3.1	6.1	-0.3	2.5
Ever used hormone-replacement therapy (HRT)	1.3	1.7	3.4	-1.8	-0.1
Had menopause	1.3	1.7	2.4	-1.6	-0.9
Medication: Ramipril	1.3	1.6	2.7	1.6	0.8
Illnesses of siblings	1.3	1.9	3.1	0.8	-1.8
Noisy workplace	1.3	1.6	3.2	1.8	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	3.8	1.9	0.4
Loud music exposure frequency	1.3	1.4	2.8	1.7	-0.2
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	4.5	0.7	2.1
Cardiovascular Disease	1.2	3.9	4.6	-2.1	-1.8
Nervous feelings	1.2	2.3	2.4	-1.5	-1.6
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	2.0	1.0	1.4
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.8	0.1	-1.7
Suffer from ‘nerves’	1.2	1.9	2.6	-1.1	-1.6
Smoking status: Current	1.2	2.0	3.8	-0.4	1.9
Neuroticism (2016)	1.1	1.7	1.8	-1.2	-1.4
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.5	0.5	-1.6
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.4	1.6	0.0
Mouth/teeth dental problems	1.1	1.7	3.0	0.6	1.7
Overall health rating	1.1	2.4	4.6	2.1	0.5
Hypothyroidism (self reported)	1.0	2.2	4.4	0.3	2.1
Average weekly spirits intake	1.0	1.3	2.1	-0.7	1.4
Taking other prescription medications	1.0	1.6	3.2	1.8	0.1
Breastfed as a baby	1.0	1.3	2.5	0.1	1.6
Age at first live birth	1.0	1.7	3.4	-1.8	-0.1
Medication: Blood pressure	1.0	1.7	3.0	-0.6	1.7
Leg pain on walking	1.0	1.2	2.0	0.7	1.4
Qualifications: nursing, teaching	1.0	1.5	3.1	-1.8	-0.1
Osteoporosis (self-reported)	1.0	1.2	2.2	-0.5	-1.5
Age started oral contraceptive pill	1.0	1.2	1.9	-0.7	1.4
Bipolar Disorder (2018)	0.9	1.5	1.5	-1.2	1.2
Neuroticism (Nagel 2018)	0.9	2.1	2.3	-1.5	-1.4
Schizophrenia (2018)	0.9	1.9	3.6	0.4	-1.9
Relative age voice broke	0.9	1.3	1.7	-1.3	-1.0
Supplements: Glucosamine	0.9	1.1	1.5	-0.9	1.2
Medication: Levothyroxine sodium	0.9	1.5	2.1	0.9	1.5
Sitting height	0.9	6.4	11.4	1.2	3.4
Allergy	0.9	2.0	3.4	-1.9	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	2.4	0.6	-1.6
Number of full brothers	0.9	1.1	1.9	1.4	-0.6
Commuting to job workplace: Walk	0.9	1.0	1.9	-1.4	-0.2
Number of operations (self-reported)	0.9	1.4	2.4	1.6	0.6
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.0	1.4	0.4
Alcohol drinker status: Previous	0.9	1.0	1.9	-1.4	-0.3
HbA1C	0.8	0.9	1.2	1.1	0.8
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.6	-0.4	1.3
Lung FVC	0.8	4.2	8.1	-0.6	-2.8
Number of treatments/medications taken	0.8	1.4	2.6	1.6	-0.5
Current tobacco smoking	0.8	1.4	2.7	0.0	1.7
Average weekly fortified wine intake	0.8	1.0	1.5	1.2	-0.7
Pain all over the body in last month	0.8	0.9	1.7	1.3	-0.2
Worrier / anxious feelings	0.8	1.5	1.8	-1.1	-1.3
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	2.7	-0.1	1.6
Birth weight	0.8	1.7	2.7	0.8	1.6
Angina (self-reported)	0.8	1.1	2.1	-0.1	-1.4
Chest pain or discomfort	0.8	1.2	2.4	1.5	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.7	-0.3	1.3
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.9	-1.4	-0.0
Pack years of smoking	0.8	1.2	1.5	-1.0	1.2
Sensitivity / hurt feelings	0.7	1.1	1.3	1.1	-1.0
Angina	0.7	0.9	1.8	-0.3	-1.4
Pack years adult smoking proportion	0.7	1.1	1.8	-0.5	1.4
Hayfever, allergic rhinitis or eczema	0.7	1.5	2.8	0.5	1.7
Father’s age at death	0.7	1.0	1.8	-1.3	0.4
Happiness	0.7	0.8	1.6	-0.2	-1.3
Medication: Paracetamol	0.7	1.2	2.4	-0.3	-1.6
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.5	0.4	-1.2
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.3	1.1	-0.5
Number of self-reported non-cancer illnesses	0.7	1.2	2.5	1.6	-0.1
Alzheimer’s Disease (in mother)	0.6	0.7	1.3	-1.1	0.2
Alzheimer’s Disease (including proxy)	0.6	0.8	1.4	-0.5	-1.2
Heel T-Score	0.6	5.2	6.0	2.1	2.4
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.3	0.1	-1.1
Medication: Co-codamol	0.6	0.7	0.9	0.9	0.7
Fed-up feelings	0.6	1.1	1.9	1.4	-0.4
Qualifications: None of the above	0.6	1.4	2.7	1.7	0.1
Fluid intelligence score	0.6	1.3	2.6	0.1	-1.6
Mean time to correctly identify matches	0.6	1.1	2.0	1.4	-0.5
Number of full sisters	0.6	0.7	1.4	-1.2	0.2
Knee pain experienced in last month	0.6	0.9	1.6	0.4	-1.3
Guilty feelings	0.6	0.9	1.2	-1.1	-0.8
Medication: Bendroflumethiazide	0.6	0.9	1.5	0.6	1.2
Medication: Paracetamol	0.6	1.0	1.9	-0.0	-1.4
Alcohol drinker status: Never	0.6	0.7	1.0	-0.6	-1.0
Irritable Bowel Disease (IBD)	0.5	1.2	1.9	-0.7	1.4
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.0	-0.4	-1.4
Blood White Count	0.5	3.7	6.5	2.5	1.0
Hand grip strength (left)	0.5	1.4	2.0	1.4	0.9
Diabetes (father)	0.5	0.7	0.7	0.8	0.8
Hand grip strength (right)	0.5	1.4	2.0	1.4	0.9
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.0	0.3	1.0
Qualifications: CSEs or equivalent	0.5	0.6	0.7	0.8	0.8
Multivitamins +/- minerals	0.5	0.6	1.1	-0.3	1.1
High blood pressure (mother)	0.5	0.7	1.1	-0.5	-1.0
Number of incorrect matches in round	0.5	0.8	1.3	-1.2	-0.4
Alcohol usually taken with meals	0.5	0.9	1.1	-0.8	-1.1
Length of working week for main job	0.5	0.5	1.0	1.0	0.3
Medication: Amlodipine	0.5	0.7	1.0	-0.6	1.0
Exposure to tobacco smoke outside home	0.5	0.6	1.1	1.1	0.4
Qualifications: College or University degree	0.5	1.7	3.4	-1.8	-0.1
Illnesses of father: Heart disease	0.5	0.7	1.3	1.1	0.1
Average weekly red wine intake	0.5	0.7	1.2	-0.5	1.1
Illnesses of father: None of the above (group 1)	0.5	0.7	1.1	-1.1	-0.4
Medication: Blood pressure	0.5	0.9	1.7	1.3	0.4
Medication: Lisinopril	0.5	0.6	0.7	0.7	0.8
Unable to work because of sickness or disability	0.5	0.7	1.3	1.2	-0.3
Heart disease (siblings)	0.5	0.7	0.7	0.8	0.9
Reaction Time	0.4	0.8	1.5	1.2	-0.1
Prostate Cancer	0.4	0.6	0.8	-0.6	0.9
Lung FEV1/FVC ratio	0.4	2.2	3.6	0.9	1.9
Ever had hysterectomy (womb removed)	0.4	0.5	0.5	-0.7	0.7
Heart attack	0.4	0.6	0.7	0.6	-0.9
Number of live births	0.4	0.6	1.0	-1.0	-0.4
Depression (self-reported)	0.4	0.5	0.9	-0.3	0.9
Glaucoma (self-reported)	0.4	0.5	0.7	0.8	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.1	-0.2	1.1
Medication for pain relief, constipation, heartburn	0.4	0.6	1.2	0.0	1.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.7	-0.5	0.8
Supplements: Vitamin C	0.4	0.5	1.0	-1.0	-0.2
Medication for cholesterol	0.4	0.6	1.0	-0.5	1.0
Osteoarthritis (self-reported)	0.4	0.6	1.0	0.4	-1.0
Wears glasses or contact lenses	0.4	0.4	0.8	-0.2	0.9
Mother’s age at death	0.4	0.6	1.1	-1.0	0.1
Commuting to job workplace: Public transport	0.4	0.5	0.9	-0.2	0.9
Ever depressed for a whole week	0.4	0.4	0.9	0.1	0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.8	0.3	-0.9
Breast Cancer	0.3	0.7	0.8	0.9	0.7
Coronary Artery Disease (CAD)	0.3	0.4	0.6	0.5	-0.7
Crohns Disease (2012)	0.3	0.5	0.7	-0.8	-0.7
Blood Red Count	0.3	2.7	3.5	1.4	-1.9
Respiratory disease	0.3	0.7	1.2	1.1	0.3
Medication for hormone replacement therapy	0.3	0.3	0.4	-0.7	0.5
Townsend deprivation index at recruitment	0.3	0.4	0.5	-0.5	-0.7
Medication: Atenolol	0.3	0.3	0.6	-0.2	-0.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	0.0	-0.9
Pulse wave Arterial Stiffness index	0.3	0.3	0.5	-0.3	0.7
Standing height	0.3	3.2	6.2	-0.5	2.5
Hair/balding pattern: Pattern 4	0.3	0.8	0.9	0.8	-0.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.8	-0.9	-0.5
Medication: Omeprazole	0.3	0.4	0.7	0.4	0.8
Alcohol intake frequency.	0.3	0.6	1.0	0.4	1.0
Had major operations	0.3	0.3	0.7	-0.0	0.8
Illnesses of siblings: Diabetes	0.3	0.3	0.5	0.4	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.2	0.5	1.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.6	0.6	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.7	-0.2	-0.9
Medication: Aspirin	0.3	0.4	0.9	-0.2	-0.9
Bipolar Disorder or Schizophrenia	0.2	0.4	0.6	-0.5	-0.8
Depression (Nagel 2018)	0.2	0.4	0.6	-0.2	-0.8
Alzheimer’s Disease (in father)	0.2	0.2	0.3	-0.6	-0.1
Lupus	0.2	0.2	0.3	0.5	-0.4
Primary Biliary Cirrhosis	0.2	0.3	0.5	0.7	0.4
Triglycerides	0.2	0.3	0.6	0.7	0.0
Systolic Blood Pressure	0.2	0.9	1.5	-0.4	-1.2
Allergy or Eczema	0.2	0.5	0.7	-0.5	0.8
Hair Pigment	0.2	7.0	13.8	0.6	-3.7
Serious illness, injury or assault to yourself	0.2	0.3	0.4	0.6	0.4
Stomach or abdominal pain in last month	0.2	0.3	0.5	0.7	-0.0
Forced vital capacity (FVC)	0.2	0.7	0.9	0.8	-0.9
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	0.8	0.7	-0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.9	-0.9	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.7	-0.2
Asthma	0.2	0.4	0.7	0.9	0.1
Birth weight of first child	0.2	0.4	0.6	0.5	-0.8
Medication: Ibuprofen	0.2	0.2	0.2	-0.4	-0.4
Age at last live birth	0.2	0.4	0.6	-0.8	-0.4
Eye problems/disorders: Cataract	0.2	0.3	0.5	0.1	-0.7
Mineral and other dietary supplements	0.2	0.3	0.4	0.6	-0.4
Asthma (self-reported)	0.2	0.4	0.8	0.9	0.1
Eye problems/disorders: Glaucoma	0.2	0.3	0.4	0.6	-0.3
Commuting to job workplace: Cycle	0.2	0.2	0.4	-0.6	0.3
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	0.3	-0.6
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	-0.2	-0.6
Bipolar Disorder (2011)	0.1	0.1	0.1	-0.4	0.2
Blood Eosinophil Count	0.1	0.5	0.7	0.9	0.5
Height	0.1	1.4	2.6	0.3	1.6
Chronotype (morning person)	0.1	0.1	0.2	-0.4	-0.3
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.4	-0.1
Vitamin and mineral supplements	0.1	0.2	0.3	0.5	-0.4
Supplements: Zinc	0.1	0.2	0.2	0.3	0.5
High blood pressure	0.1	0.4	0.7	-0.2	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.1	0.4	-0.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	0.4	-0.2
Falls in the last year	0.1	0.1	0.3	-0.5	0.0
Prospective memory result	0.1	0.1	0.3	-0.0	0.5
Lung cancer (father)	0.1	0.1	0.2	-0.3	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.3	0.2	-0.6
Peak expiratory flow (PEF)	0.1	0.3	0.5	0.7	0.2
Blood clot in the leg (DVT)	0.1	0.1	0.1	0.4	0.2
Forced vital capacity (FVC), Best measure	0.1	0.3	0.5	-0.0	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.4	-0.1
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.2	-0.5
Neck or shoulder pain in last month	0.1	0.1	0.2	0.2	-0.5
Medication: Aspirin	0.1	0.2	0.3	0.1	-0.6
Hypertension (Self-reported)	0.1	0.4	0.7	-0.1	0.9
Loneliness, isolation	0.1	0.1	0.1	0.2	0.3
Back pain experienced in last month	0.1	0.1	0.2	0.1	-0.4
Financial situation satisfaction	0.1	0.1	0.2	0.1	-0.5
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.2	-0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	0.2	0.3
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.2	-0.4
Ever smoked	0.1	0.1	0.2	-0.0	-0.5
Risk taking	0.1	0.2	0.2	-0.5	0.4
Fractured/broken bones in last 5 years	0.1	0.2	0.3	-0.2	-0.5
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.4	0.4	-0.6
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	0.1	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.4	0.2
Crohns Disease (2017)	0.0	0.1	0.1	0.0	-0.4
Major Depression (MDD)	0.0	0.0	0.0	0.1	0.1
Waist Hip Ratio (WHR)	0.0	0.1	0.1	-0.4	0.2
Tanning	0.0	0.2	0.3	0.3	-0.5
Systolic blood pressure, automated reading	0.0	0.0	0.0	0.2	0.2
Severe depression (siblings)	0.0	0.0	0.0	-0.0	-0.0
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	0.1	0.1
Past tobacco smoking	0.0	0.0	0.0	-0.2	-0.2
Hearing difficulty/problems with background noise	0.0	0.0	0.1	0.3	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.1	0.1	0.2	0.3
Illnesses of mother	0.0	0.0	0.1	-0.3	-0.1
Pulse wave peak to peak time	0.0	0.0	0.1	0.1	-0.2
Eye problems/disorders: None of the above	0.0	0.0	0.0	0.1	-0.2
Medication: Seretide 50 evohaler	0.0	0.0	0.1	-0.0	-0.2
Family relationship satisfaction	0.0	0.0	0.1	-0.3	-0.0
Smoking status: Previous	0.0	0.0	0.0	0.1	-0.2
Breast cancer (self-reported)	0.0	0.0	0.1	0.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	0.0	-0.3
Average weekly champagne plus white wine intake	0.0	0.0	0.0	0.2	0.2
Hearing aid user	0.0	0.0	0.0	0.1	-0.2

Hub : Genes

ANKDD1B

Models

Trait associations