Best TWAS P=8.03e-10 · Best GWAS P=1.02e-09 conditioned to 0.0846
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ANKRD45 | 0.11 | 0.11 | bslmm | 303 | 0.12 | 7.5e-14 | -4.57 | 5.2 | 2.0e-07 | -0.82 | 0.94 | 0.06 | FALSE |
2 | GTEx | Adrenal Gland | RC3H1 | 0.12 | 0.06 | lasso | 2 | 0.06 | 3.2e-03 | -5.84 | 5.9 | 2.9e-09 | -0.98 | 0.04 | 0.80 | FALSE |
3 | GTEx | Artery Tibial | RC3H1 | 0.09 | 0.07 | lasso | 2 | 0.07 | 2.6e-06 | -5.84 | 5.9 | 4.0e-09 | -0.98 | 0.03 | 0.96 | FALSE |
4 | GTEx | Breast Mammary Tissue | RC3H1 | 0.17 | 0.05 | enet | 30 | 0.05 | 2.2e-03 | -5.79 | 5.7 | 1.5e-08 | -0.77 | 0.04 | 0.93 | FALSE |
5 | GTEx | Breast Mammary Tissue (Male) | RC3H1 | 0.07 | 0.11 | enet | 3 | 0.07 | 9.9e-03 | -5.97 | 6.0 | 2.0e-09 | -1.00 | 0.03 | 0.56 | FALSE |
6 | GTEx | Breast Mammary Tissue (Female) | RABGAP1L | 0.19 | 0.00 | lasso | 3 | 0.01 | 2.0e-01 | -5.91 | -5.7 | 1.2e-08 | 0.92 | 0.06 | 0.40 | FALSE |
7 | GTEx | Esophagus Muscularis | RC3H1 | 0.10 | 0.08 | lasso | 13 | 0.06 | 1.2e-04 | -5.91 | 5.9 | 3.1e-09 | -0.98 | 0.03 | 0.97 | FALSE |
8 | GTEx | Nerve Tibial | RC3H1 | 0.09 | 0.06 | enet | 7 | 0.07 | 7.0e-06 | -5.84 | 5.9 | 4.7e-09 | -0.97 | 0.04 | 0.96 | FALSE |
9 | GTEx | Ovary | RC3H1 | 0.32 | 0.03 | lasso | 8 | 0.07 | 8.6e-03 | -5.91 | 5.5 | 3.5e-08 | -0.82 | 0.03 | 0.54 | FALSE |
10 | GTEx | Testis | RC3H1 | 0.13 | 0.03 | enet | 24 | 0.06 | 8.0e-04 | -5.90 | 5.8 | 7.1e-09 | -0.88 | 0.04 | 0.93 | FALSE |
11 | METSIM | Adipose | SERPINC1 | 0.10 | 0.09 | bslmm | 271 | 0.09 | 1.2e-13 | -5.79 | -6.1 | 9.4e-10 | 0.95 | 0.04 | 0.96 | FALSE |
12 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | MRPS14 | 0.12 | 0.05 | lasso | 3 | 0.03 | 6.5e-04 | -5.25 | -5.3 | 1.4e-07 | 0.95 | 0.00 | 0.98 | FALSE |
13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DARS2 | 0.04 | 0.00 | blup | 36 | 0.01 | 5.9e-04 | -0.12 | -5.5 | 3.7e-08 | 0.66 | 0.01 | 0.44 | FALSE |
14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RABGAP1L | 0.07 | 0.01 | lasso | 3 | 0.01 | 1.2e-02 | -5.25 | -5.3 | 1.2e-07 | 0.97 | 0.03 | 0.94 | FALSE |
15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SERPINC1 | 0.14 | 0.09 | blup | 47 | 0.09 | 1.2e-17 | -5.79 | -6.1 | 1.1e-09 | 0.93 | 0.01 | 0.99 | FALSE |
16 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | DARS2 | 0.14 | 0.00 | blup | 37 | 0.01 | 8.2e-02 | -5.84 | -5.6 | 1.8e-08 | 0.75 | 0.00 | 0.43 | FALSE |
17 | The Cancer Genome Atlas | Colon Adenocarcinoma | SERPINC1 | 0.10 | 0.06 | blup | 47 | 0.06 | 1.8e-04 | -4.87 | -5.5 | 4.3e-08 | 0.76 | 0.02 | 0.79 | FALSE |
18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SERPINC1 | 0.13 | 0.03 | blup | 47 | 0.03 | 1.7e-04 | -5.84 | -5.6 | 1.8e-08 | 0.93 | 0.01 | 0.98 | FALSE |
19 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SERPINC1 | 0.31 | 0.07 | lasso | 2 | 0.05 | 6.8e-04 | -5.73 | -5.6 | 2.4e-08 | 0.93 | 0.01 | 0.98 | FALSE |
20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SERPINC1 | 0.06 | 0.02 | blup | 48 | 0.02 | 1.7e-03 | -5.79 | -5.2 | 2.2e-07 | 0.92 | 0.01 | 0.95 | FALSE |
21 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | RC3H1 | 0.15 | 0.00 | blup | 58 | 0.03 | 1.8e-02 | -5.84 | -5.4 | 8.5e-08 | 0.89 | 0.02 | 0.56 | FALSE |
22 | The Cancer Genome Atlas | Lung Adenocarcinoma | SERPINC1 | 0.08 | 0.04 | blup | 48 | 0.05 | 5.8e-07 | -5.91 | -6.1 | 8.0e-10 | 0.84 | 0.01 | 0.99 | TRUE |
23 | The Cancer Genome Atlas | Lung Adenocarcinoma | ZBTB37 | 0.07 | 0.00 | blup | 47 | 0.03 | 2.2e-04 | 3.16 | -5.4 | 5.6e-08 | 0.66 | 0.02 | 0.54 | FALSE |
24 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CACYBP | 0.11 | 0.05 | lasso | 2 | 0.04 | 9.6e-04 | -5.25 | -5.3 | 1.1e-07 | 0.95 | 0.00 | 0.96 | FALSE |
25 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | MRPS14 | 0.12 | 0.01 | lasso | 4 | 0.01 | 1.1e-01 | -5.25 | -5.7 | 1.3e-08 | 0.94 | 0.00 | 0.91 | FALSE |
26 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SERPINC1 | 0.32 | 0.11 | enet | 10 | 0.12 | 1.6e-05 | -5.91 | -5.8 | 7.6e-09 | 0.84 | 0.01 | 0.98 | FALSE |
27 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SERPINC1 | 0.08 | 0.01 | blup | 47 | 0.03 | 1.6e-04 | -5.79 | -6.1 | 9.4e-10 | 0.77 | 0.01 | 0.87 | FALSE |
28 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SERPINC1 | 0.12 | 0.08 | lasso | 5 | 0.08 | 2.4e-05 | -5.84 | -5.7 | 1.2e-08 | 0.91 | 0.01 | 0.97 | FALSE |
29 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SERPINC1 | 0.09 | 0.04 | lasso | 5 | 0.04 | 5.8e-04 | -5.91 | -5.4 | 5.9e-08 | 0.96 | 0.01 | 0.98 | FALSE |
30 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RC3H1 | 0.13 | -0.01 | blup | 58 | 0.01 | 1.4e-01 | -5.84 | -5.6 | 2.4e-08 | 0.80 | 0.01 | 0.25 | FALSE |