Hub : Genes

ANKRD45

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1140	0.0350	9.2e-08	0.108	0.073	0.103	0.115	0.103	4.7e-13	3.6e-09	1.5e-12	7.5e-14	1.5e-12
2	ROSMAP	Brain Pre-frontal Cortex	0.0929	0.0268	3.1e-11	0.119	0.088	0.098	0.096	0.111	4.4e-15	2.3e-11	1.3e-12	2.6e-12	4.8e-14
3	TCGA	Bladder Urothelial Carcinoma	0.0380	0.0220	5.0e-03	0.002	0.027	0.033	NA	0.021	1.9e-01	2.1e-03	8.5e-04	NA	5.9e-03
4	TCGA	Brain Lower Grade Glioma	0.1426	0.0530	3.6e-05	0.011	0.036	0.064	NA	0.065	1.8e-02	5.2e-05	8.9e-08	NA	6.9e-08
5	TCGA	Prostate Adenocarcinoma	0.0853	0.0375	3.0e-07	0.079	0.059	0.081	NA	0.074	1.1e-08	8.4e-07	7.2e-09	NA	3.3e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.8	2.8	9.3	1.0	0.6	0.4	3.1	1.8
Bipolar Disorder or Schizophrenia	1.6	3.9	6.9	2.3	2.6	-2.0	1.5	-1.0
Depressed Affect (Nagel 2018)	2.7	5.6	14.6	-1.6	-0.7	-2.1	-3.8	-2.4
Depression (Nagel 2018)	2.5	3.7	7.0	-0.3	0.2	-2.3	-2.6	-2.5
Intelligence (Savage-Jansen 2018)	1.3	4.0	6.4	-2.5	-2.5	1.1	1.0	2.3
Neuroticism (Nagel 2018)	1.9	4.5	12.2	-1.5	-0.7	-2.0	-3.5	-1.9
Schizophrenia (2018)	3.0	6.3	10.2	2.1	2.9	-2.8	-0.6	-3.2
Schizophrenia vs Biploar Disorder	9.3	12.3	21.4	2.5	3.6	-4.0	-2.2	-4.6
Worry (Nagel 2018)	2.0	4.2	7.5	0.5	0.9	-2.4	-2.7	-2.5
Alzheimer’s Disease (in mother)	0.8	0.9	2.6	0.4	0.5	-1.6	-0.1	-1.3
Alzheimer’s Disease (in father)	0.6	0.7	1.3	1.0	1.1	-0.8	-0.0	-0.8
Alzheimer’s Disease (including proxy)	1.0	1.5	3.2	1.1	1.2	-1.8	0.5	-1.1
Crohns Disease (2017)	0.7	1.5	3.1	-0.0	-0.1	1.8	1.6	1.3
Irritable Bowel Disease (IBD)	0.2	0.5	1.1	0.4	0.4	0.9	1.1	0.5
Ulcerative Colitis (UC)	0.2	0.4	0.7	0.8	0.9	0.1	0.4	-0.4
Major Depression (MDD)	0.6	0.7	2.5	0.1	0.4	-1.6	-0.7	-0.8
Reaction Time	0.4	0.8	2.0	0.5	0.6	-0.6	1.4	0.9
Verbal and Numeric Reasoning (VNR)	0.9	2.2	3.3	-1.7	-1.7	1.1	0.8	1.8
Breast Cancer	0.4	1.0	1.7	1.2	1.3	-0.7	0.9	-0.5
Ovarian Cancer	0.4	0.5	1.1	-0.8	-1.0	-0.8	-0.1	0.4
Prostate Cancer	0.3	0.4	1.0	0.5	0.8	-0.5	-0.1	-1.0
Age at First Birth	0.9	1.3	2.2	-1.4	-1.5	1.1	-0.2	0.9
Bipolar Disorder (2011)	0.7	0.6	1.8	0.3	0.0	0.4	1.3	1.1
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	0.4	0.5	-0.6	0.8	0.2
Coronary Artery Disease (CAD)	0.6	0.8	2.0	-0.4	-0.6	1.4	0.5	1.0
Crohns Disease (2012)	1.0	1.5	3.0	0.8	0.6	1.7	1.7	0.8
Mean Putamen Volume	3.0	3.4	6.3	-2.4	-2.0	-0.9	-2.5	-0.4
Fasting Glucose	0.6	0.7	2.0	-0.0	-0.1	0.7	0.9	1.4
HbA1C	0.5	0.5	1.2	-1.1	-1.0	0.3	-0.3	0.6
HDL Cholesterol	0.2	0.3	1.4	0.1	0.1	-1.2	-0.3	-0.1
LDL Cholesterol	0.7	1.0	1.9	1.3	1.3	-0.1	1.4	0.1
Lupus	2.6	4.0	7.3	-2.5	-1.7	-1.3	-2.7	-1.4
Neuroticism (2016)	2.4	3.5	8.0	-0.8	-0.1	-1.9	-2.8	-2.2
Primary Biliary Cirrhosis	0.4	0.6	1.0	1.0	0.7	0.5	0.8	0.6
Rheumatoid Arthritis	1.7	2.3	6.4	0.7	1.6	-1.0	-1.0	-2.5
Schizophrenia (2014)	4.7	10.3	16.9	3.5	4.1	-3.2	-0.1	-3.4
Triglycerides	0.4	0.6	1.1	1.0	1.1	0.1	0.6	-0.7
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.6	0.7	0.7	0.8	0.8	0.2
Ulcerative Colitis	1.1	1.6	3.4	1.6	1.8	-0.9	0.5	-0.9
Blood Eosinophil Count	0.2	1.8	4.8	2.0	2.2	-0.2	0.6	-0.4
Blood Platelet Count	0.4	4.8	9.5	3.1	2.9	-0.4	2.4	0.5
Blood Red Count	1.1	10.7	23.9	2.4	3.2	-2.9	-2.4	-4.9
Blood White Count	1.4	10.3	20.2	3.3	4.0	-4.5	0.1	-2.2
Heel T-Score	2.2	17.5	39.3	-2.8	-0.9	-4.0	-6.3	-4.9
BMI	3.6	20.8	45.0	-6.7	-5.9	1.2	-4.7	-0.1
Height	0.6	10.9	29.7	1.4	0.5	2.2	5.5	4.2
Waist Hip Ratio (WHR)	0.9	4.0	8.1	-0.9	-0.1	-2.5	-2.9	-2.1
Systolic Blood Pressure	1.1	5.4	11.0	3.3	3.2	-1.3	2.0	-0.1
Smoking Status	2.3	5.4	9.8	0.4	1.3	-2.6	-2.9	-3.1
Allergy or Eczema	1.1	3.0	6.0	2.2	2.5	0.3	2.0	-0.1
Cardiovascular Disease	0.1	0.3	0.8	0.3	0.3	-0.3	0.9	0.7
Hypothyroidism (self reported)	1.2	2.9	6.1	2.0	2.5	-1.2	0.3	-1.6
Respiratory disease	2.2	4.8	9.8	2.1	3.1	-2.0	-0.4	-2.3
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.1	-0.5	-0.1	-0.1	-1.1	-0.6
Lung FEV1/FVC ratio	0.6	3.1	5.7	-2.2	-2.4	-0.5	-2.1	-0.3
Lung FVC	1.6	8.4	14.1	-2.5	-3.5	3.7	0.5	3.0
Neuroticism	1.9	4.6	11.4	-0.5	0.3	-2.2	-3.4	-2.6
Chronotype (morning person)	2.0	4.5	9.2	2.7	2.1	0.6	3.0	1.0
Hair Pigment	0.1	3.6	5.6	2.0	2.4	-1.9	-0.6	-2.2
Tanning	0.0	0.4	0.6	0.3	0.5	-0.7	-0.7	-0.8
Hand grip strength (left)	0.6	1.7	3.1	1.7	1.8	-0.5	0.3	-1.4
Number of treatments/medications taken	3.0	5.5	8.8	1.2	2.0	-3.0	-2.0	-3.0
Average weekly spirits intake	2.6	3.2	6.0	-2.4	-2.2	0.1	-2.3	-0.3
Sensitivity / hurt feelings	1.1	1.9	3.8	-1.9	-1.9	0.7	-1.0	0.7
Frequency of depressed mood in last 2 weeks	2.0	2.8	5.1	-0.1	0.4	-2.0	-2.3	-2.2
Hearing difficulty/problems: Yes	2.4	3.6	6.4	2.0	2.5	-2.2	-0.1	-1.6
Relative age of first facial hair	1.4	2.8	4.8	-1.7	-2.2	0.4	1.4	2.1
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.5	-1.3	-0.9	0.3	-1.9	-1.0
Ever used hormone-replacement therapy (HRT)	1.2	1.5	4.0	0.6	0.1	0.5	1.7	2.0
Ever had hysterectomy (womb removed)	0.9	1.1	2.7	0.0	0.1	-0.1	-1.6	-1.6
Systolic blood pressure, automated reading	0.2	0.6	1.2	1.0	1.1	-0.9	0.2	-0.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.6	-0.7	-0.8	0.8	-0.4	-0.1
Angina	0.9	1.1	2.4	-0.6	-0.3	-1.1	-1.6	-1.3
Medication for hormone replacement therapy	0.2	0.2	0.8	-0.0	-0.2	-0.3	0.5	0.9
Vitamin and mineral supplements	2.8	3.8	7.5	-2.5	-2.7	2.0	-1.0	0.7
Supplements: Zinc	0.7	0.8	1.5	0.9	1.0	-1.2	0.8	-0.1
Medication: Co-codamol	2.5	2.9	8.1	-1.8	-1.8	-0.5	-2.8	-0.2
Medication: Metformin	0.0	0.0	0.2	0.0	0.1	0.5	-0.0	-0.0
Diabetes (father)	0.1	0.1	0.2	0.2	0.1	0.4	0.5	0.2
Diabetes (mother)	0.2	0.3	0.4	-0.4	-0.3	-0.6	-0.6	-0.5
Severe depression (siblings)	0.2	0.3	0.9	-0.1	0.2	0.0	-0.9	-0.6
Pack years adult smoking proportion	1.2	1.9	3.8	0.5	0.9	-1.4	-1.6	-2.0
Impedance of leg (right)	1.9	9.0	16.3	4.0	3.6	-1.2	3.7	0.6
Leg fat-free mass (left)	1.8	9.6	21.8	-4.7	-4.3	0.8	-2.5	0.9
Trunk fat percentage	1.6	6.2	11.6	-3.1	-2.1	-1.8	-3.4	-1.5
Hand grip strength (right)	0.3	0.7	2.2	0.6	0.8	0.3	-0.4	-1.5
Townsend deprivation index at recruitment	1.4	1.9	4.7	1.9	2.2	0.1	0.8	-0.7
Current tobacco smoking	1.9	3.0	5.7	-0.5	0.1	-2.0	-2.4	-2.2
Average weekly fortified wine intake	0.5	0.6	1.4	-1.0	-1.2	0.2	-0.4	0.7
Maternal smoking around birth	0.5	0.7	1.6	-1.1	-0.7	-0.0	-1.3	-0.0
Fed-up feelings	2.4	4.3	9.7	-1.7	-0.9	-2.2	-3.1	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	2.9	0.8	1.1	-1.6	-1.5	-1.7
Relative age voice broke	1.3	2.1	4.8	-2.2	-2.2	0.3	-0.5	0.6
Taking other prescription medications	2.7	4.2	8.9	0.2	1.0	-2.0	-2.7	-3.0
Age when periods started (menarche)	2.8	6.8	10.9	-2.4	-3.3	2.9	0.6	3.0
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.4	-0.9	-1.2	0.4	-1.2	0.1
Heel bone mineral density (BMD) T-score, automated (left)	2.7	6.2	11.8	-3.2	-2.5	-0.6	-3.4	-1.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.5	-0.4	0.2	0.3	0.7
Qualifications: CSEs or equivalent	1.2	1.6	3.0	-0.8	-0.4	-1.2	-1.7	-1.7
Serious illness, injury or assault to yourself	0.4	0.5	1.1	0.5	0.3	1.1	0.8	0.4
High blood pressure	0.3	0.9	1.7	1.3	1.3	-0.5	0.9	0.2
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.2	1.3	1.5	0.7	1.8	0.2
Multivitamins +/- minerals	1.3	1.7	3.0	1.7	1.7	-1.2	1.0	-0.4
Stomach or abdominal pain in last month	0.1	0.1	0.6	0.2	0.2	-0.8	0.1	-0.1
Supplements: Glucosamine	0.3	0.5	1.4	0.0	-0.2	0.8	0.5	1.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.7	0.2	-0.0	-0.1	0.4	0.8
Medication: Atenolol	0.9	1.1	2.2	-1.4	-1.5	-0.1	-1.1	0.6
Medication: Levothyroxine sodium	0.5	0.8	1.6	0.8	1.2	-0.8	-0.2	-1.1
Sitting height	0.0	0.2	0.7	0.2	0.2	0.7	0.8	0.0
Chronic bronchitis/emphysema (father)	1.0	1.1	3.4	-0.5	0.2	-1.0	-1.9	-1.0
High blood pressure (mother)	1.0	1.4	2.7	1.2	1.3	-1.6	-0.3	-1.1
Body mass index (BMI)	3.3	14.2	29.2	-5.4	-4.5	-0.2	-4.5	-1.1
Impedance of leg (left)	2.1	10.3	20.3	4.5	4.2	-1.0	3.5	0.0
Leg predicted mass (left)	1.7	9.2	21.1	-4.6	-4.2	0.7	-2.4	0.8
Trunk fat mass	1.9	8.4	17.3	-4.2	-3.2	-1.2	-3.5	-0.9
Waist circumference	2.8	10.3	19.1	-4.4	-3.4	-1.8	-4.0	-1.0
Number of incorrect matches in round	2.9	4.8	9.6	2.8	3.1	-1.3	0.4	-2.3
Past tobacco smoking	2.6	4.7	9.4	0.3	-0.5	2.7	3.1	2.6
Alcohol usually taken with meals	11.6	18.7	34.6	-1.6	-3.1	5.4	4.3	5.9
Nervous feelings	0.7	1.3	3.4	0.1	0.3	-1.2	-1.8	-1.3
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.6	7.5	0.1	0.5	-2.1	-2.4	-2.7
Hearing difficulty/problems with background noise	1.1	1.8	3.7	0.8	1.4	-1.9	-0.7	-1.6
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	0.0	-0.2	0.6	0.4	0.5
Had menopause	0.2	0.2	0.9	0.1	-0.1	0.9	0.6	0.1
Had other major operations	2.4	2.9	7.9	-1.0	-0.6	-1.2	-2.8	-1.9
Forced vital capacity (FVC)	1.6	6.1	12.0	-1.1	-1.9	2.9	2.3	3.5
Heel bone mineral density (BMD) T-score, automated (right)	3.6	8.3	18.7	-3.3	-2.3	-1.1	-4.3	-2.3
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	3.5	-1.1	-0.7	-1.4	-1.9	-0.9
Qualifications: None of the above	1.1	2.4	4.8	1.1	1.7	-1.2	-1.3	-2.2
Financial difficulties in last 2 years	1.0	1.3	2.6	0.6	1.0	-1.6	-0.9	-1.4
Mouth/teeth dental problems	0.4	0.6	1.8	-0.3	-0.3	1.3	0.9	0.6
Heart attack	0.6	0.7	2.0	-0.8	-0.6	-0.0	-1.4	-0.7
Allergy	1.2	2.8	6.5	-2.1	-2.5	0.2	-1.6	0.5
Pain all over the body in last month	2.3	2.5	4.5	-0.9	-0.2	-2.0	-2.1	-1.8
Diabetes (self-reported)	0.1	0.1	0.2	-0.2	0.1	-0.3	-0.5	-0.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	-0.0	0.8	-0.6	-0.9	-1.0
Medication: Ramipril	0.6	0.8	2.1	-0.8	-0.5	-0.5	-1.4	-1.0
Medication: Simvastatin	0.4	0.5	1.1	-0.7	-0.6	-1.0	-0.8	-0.1
Fluid intelligence score	1.5	3.1	5.8	-2.3	-2.4	1.1	-0.1	1.8
Illnesses of siblings	0.1	0.1	0.2	-0.0	-0.1	0.5	0.1	-0.3
Neuroticism score	1.4	2.9	6.6	0.1	0.6	-1.9	-2.6	-2.0
Weight	2.2	11.0	25.8	-5.1	-4.5	0.6	-2.8	0.6
Impedance of arm (right)	2.9	13.3	27.0	5.2	4.6	-0.1	4.2	1.1
Arm fat percentage (right)	1.7	6.6	14.4	-3.8	-3.2	-0.1	-2.9	-0.2
Trunk fat-free mass	1.5	8.6	18.1	-4.2	-4.3	1.4	-1.0	2.0
Hip circumference	1.1	4.9	12.2	-3.5	-3.1	0.1	-1.4	0.9
Time employed in main current job	1.0	1.2	2.5	0.4	0.8	-1.2	-1.1	-1.6
Alcohol intake versus 10 years previously	4.9	7.3	14.5	3.7	3.8	0.2	2.9	-0.1
Father’s age at death	0.4	0.5	1.3	-1.0	-1.1	-0.2	-0.4	0.1
Worrier / anxious feelings	0.4	0.8	1.3	0.4	0.7	-1.1	-0.8	-1.1
Frequency of tiredness / lethargy in last 2 weeks	3.1	5.0	8.3	0.9	1.5	-2.7	-2.6	-2.9
Falls in the last year	0.4	0.6	1.6	0.5	0.6	-1.3	0.7	0.5
Hair/balding pattern: Pattern 3	0.4	0.5	1.0	0.8	1.0	-0.8	0.3	-0.6
Number of live births	0.3	0.4	1.0	-0.6	-1.0	0.4	0.1	0.5
Forced expiratory volume in 1-second (FEV1)	1.7	5.8	10.0	-1.9	-2.7	2.5	1.4	3.2
Pulse rate	1.7	2.9	6.7	0.6	1.1	-1.7	-1.8	-2.6
Happiness	1.7	2.1	4.4	1.6	1.8	-2.1	0.2	-0.5
Noisy workplace	0.4	0.5	0.8	-0.9	-0.9	0.5	-0.7	0.1
Qualifications: A levels/AS levels or equivalent	1.6	3.5	6.7	-2.3	-2.6	1.6	-0.2	1.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.9	-0.5	-0.7	0.0	0.3	0.9
Mouth/teeth dental problems: Dentures	2.5	4.2	11.3	-1.8	-1.3	-1.1	-3.4	-1.9
Asthma	1.3	2.5	5.1	1.4	2.3	-1.6	-0.4	-1.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.8	0.9	0.8	0.5	-0.1	-0.5
Medication: Cholesterol lowering	0.4	0.6	1.0	-0.8	-0.3	-1.0	-0.9	-0.5
Depression (self-reported)	5.2	6.3	15.6	-2.4	-1.7	-1.2	-4.0	-2.3
Medication: Lansoprazole	0.6	0.7	1.7	-0.7	-1.0	0.5	0.2	1.3
Prospective memory result	4.3	5.2	10.3	3.2	3.1	-1.2	2.1	-0.5
Lung cancer (father)	3.3	3.9	8.1	2.3	2.9	-1.7	0.8	-1.6
Illnesses of mother	0.4	0.5	1.1	-0.9	-1.0	0.5	-0.1	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.6	7.9	-1.8	-2.5	2.1	1.1	2.8
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.5	-0.2	0.3	-0.7	-0.3
Impedance of arm (left)	2.9	13.4	28.8	5.4	5.0	-0.9	3.5	0.2
Arm fat mass (right)	2.3	9.6	21.5	-4.6	-3.9	-0.2	-3.3	-0.3
Trunk predicted mass	1.4	8.1	17.1	-4.1	-4.1	1.4	-0.9	2.0
Standing height	0.5	4.5	10.7	0.2	-0.4	1.4	3.3	3.1
Length of working week for main job	0.4	0.4	1.0	1.0	0.9	0.4	0.3	0.0
Exposure to tobacco smoke at home	1.1	1.2	3.0	-1.3	-1.1	-0.5	-1.7	0.0
Breastfed as a baby	2.2	2.8	5.6	-2.1	-2.4	1.3	-0.9	1.1
Tense / ‘highly strung’	2.1	3.5	6.1	1.8	2.0	-1.5	-1.4	-2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	3.3	5.0	14.3	-1.9	-1.3	-1.0	-3.8	-2.1
Hair/balding pattern: Pattern 4	0.7	1.8	2.1	1.2	1.4	-1.4	-1.1	-1.4
Birth weight of first child	0.8	1.5	3.0	-0.3	-0.8	1.7	1.0	1.7
Peak expiratory flow (PEF)	1.6	3.7	7.5	-2.5	-2.7	1.6	-0.2	1.6
Pulse wave reflection index	0.6	0.7	1.4	-0.9	-0.9	1.2	0.1	0.8
Ever highly irritable/argumentative for 2 days	1.3	1.5	2.8	-1.6	-1.7	0.3	-0.7	1.4
Loud music exposure frequency	0.5	0.5	0.9	0.0	0.4	-1.0	-0.8	-0.8
Qualifications: O levels/GCSEs or equivalent	3.7	5.9	11.3	-3.2	-3.4	1.9	-1.0	1.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	0.4	0.4	-0.4	0.9	0.8
Blood clot in the leg (DVT)	0.3	0.4	1.1	0.2	-0.1	0.2	1.0	1.0
Medication: Paracetamol	2.2	3.7	7.0	2.4	2.6	-0.9	-0.4	-2.2
Headache pain in last month	3.6	6.2	14.4	2.0	2.7	-1.6	-1.8	-3.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	0.9	0.9	0.4	0.8	1.0	0.6
Glaucoma (self-reported)	0.4	0.5	1.1	-0.6	-0.5	-0.0	-1.1	-0.7
Gout (self-reported)	0.9	1.3	2.3	-1.4	-0.9	-0.6	-1.5	-0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.1	1.1	1.4	-1.0	-0.2	-1.3
Medication: Amlodipine	0.2	0.3	1.0	0.4	0.5	-1.0	0.2	0.3
Medication: Ventolin 100micrograms inhaler	0.8	1.1	2.4	-0.4	0.2	-0.5	-1.5	-1.6
Birth weight	1.3	2.8	5.3	-1.2	-1.5	2.3	1.1	1.9
Chronic bronchitis/emphysema (mother)	2.4	2.8	5.7	2.1	2.4	-1.1	-0.2	-1.6
High blood pressure (siblings)	0.1	0.2	0.4	0.6	0.4	0.0	-0.5	-0.2
Forced vital capacity (FVC), Best measure	1.4	5.1	10.6	-0.9	-1.7	2.5	2.2	3.3
Body fat percentage	1.9	7.4	13.3	-3.6	-2.7	-1.4	-3.6	-1.3
Leg fat percentage (right)	2.4	8.9	18.6	-4.3	-3.4	-1.1	-3.5	-0.9
Arm fat-free mass (right)	1.9	9.5	22.1	-4.7	-4.3	0.4	-2.5	0.5
Exposure to tobacco smoke outside home	0.2	0.3	0.7	-0.3	0.1	-0.3	-0.9	-0.8
Comparative body size at age 10	2.3	6.4	12.0	-3.5	-3.1	1.7	-2.8	-0.3
Number of full brothers	0.5	0.6	1.0	-0.7	-1.0	0.9	-0.1	0.9
Worry too long after embarrassment	0.6	1.0	3.4	-0.6	-0.4	-0.3	-1.8	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.8	-0.6	-0.6	-0.3	-0.9	-0.2
Wheeze or whistling in the chest in last year	2.6	4.6	8.1	1.5	2.7	-1.9	-1.4	-2.8
Number of children fathered	0.4	0.4	0.9	-0.7	-0.4	-0.5	-0.9	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.9	0.0	-0.2	-0.2	1.0	0.3
Age at first live birth	0.4	0.6	1.1	-0.9	-0.9	0.2	0.6	1.1
Pulse wave peak to peak time	0.3	0.3	1.0	0.4	0.1	0.0	1.0	0.7
Health satisfaction	0.9	1.1	2.6	0.3	0.9	-1.6	-1.0	-1.1
Shortness of breath walking on level ground	0.7	0.8	1.7	1.1	1.3	0.5	-0.1	-0.9
Qualifications: College or University degree	1.6	5.1	9.2	-1.5	-2.1	3.0	1.6	2.6
Eye problems/disorders: None of the above	1.3	1.5	3.1	-1.7	-1.1	-0.3	-1.8	-0.6
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.8	-0.4	-0.3	-1.3	-1.2	-0.7
Emphysema/chronic bronchitis	1.9	2.2	4.4	1.7	2.1	-1.2	-0.4	-1.4
Medication for pain relief, constipation, heartburn	1.0	1.8	3.1	-1.6	-1.8	0.1	0.8	1.6
Neck or shoulder pain in last month	1.2	1.7	3.6	-0.4	-1.0	1.8	0.5	1.9
Medication: Blood pressure	0.1	0.1	0.2	-0.2	0.0	0.2	-0.5	-0.4
Angina (self-reported)	1.1	1.5	3.5	-0.7	-0.4	-1.0	-1.9	-1.5
Migraine (self-reported)	2.7	3.4	5.9	1.4	1.8	-1.9	-1.4	-2.4
Medication: Ibuprofen	1.1	1.3	3.0	1.7	1.7	-0.3	0.1	-0.7
Medication: Allopurinol	1.0	1.3	2.8	-1.1	-0.5	-0.7	-1.7	-1.2
Medication: Omeprazole	0.5	0.6	1.5	-0.8	-0.9	0.3	-1.2	0.3
Medication: Seretide 50 evohaler	0.8	1.0	2.3	0.8	0.6	0.4	1.5	1.2
Mean time to correctly identify matches	0.3	0.5	0.9	-0.0	0.2	-0.9	0.9	0.8
Heart disease (mother)	0.4	0.5	2.2	0.2	-0.0	1.5	0.1	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.3	-1.5	-1.3	0.1	-1.1	-0.6
Whole body fat mass	2.4	10.0	21.1	-4.6	-3.7	-0.9	-3.7	-0.7
Leg fat mass (right)	2.9	11.4	25.6	-5.1	-4.2	-0.6	-3.6	-0.5
Arm predicted mass (right)	2.0	10.2	23.9	-4.9	-4.5	0.2	-2.6	0.5
Pulse rate, automated reading	5.0	16.1	35.2	-1.5	-0.1	-3.5	-5.9	-5.5
Alcohol intake frequency.	1.4	3.3	6.2	2.4	2.2	-0.4	2.5	0.1
Comparative height size at age 10	0.4	2.1	5.7	0.9	0.7	0.8	2.4	1.7
Number of full sisters	0.1	0.1	0.2	-0.2	-0.2	-0.3	0.2	0.4
Suffer from ‘nerves’	0.5	0.8	2.1	0.4	0.5	-1.4	-1.0	-0.6
Overall health rating	2.3	4.9	10.6	1.7	2.3	-3.3	-1.1	-2.1
Chest pain or discomfort	0.7	1.0	2.1	-1.1	-0.8	-0.7	-1.4	-0.5
Had major operations	1.6	1.9	3.9	-1.1	-1.6	1.1	0.7	2.0
Age at last live birth	0.3	0.5	1.5	-0.2	-0.2	0.3	1.2	0.9
Family relationship satisfaction	3.2	3.9	9.8	2.0	2.3	-3.1	0.4	-0.9
Leg pain on walking	1.3	1.6	2.8	-1.2	-1.3	1.7	-1.2	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	-0.6	-0.9	0.8	-0.2	0.8
Commuting to job workplace: Car/motor vehicle	3.6	4.1	8.9	0.8	1.4	-3.0	-1.7	-2.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	-0.2	-0.0	-0.7	0.6	0.4
Medication: Aspirin	1.0	1.3	2.2	1.0	1.3	-1.1	-0.9	-1.5
Supplements: Vitamin C	2.7	3.2	6.0	1.8	2.3	-2.4	0.4	-1.1
Knee pain experienced in last month	0.6	1.0	3.8	-0.7	-0.7	0.0	-1.9	0.2
Hypertension (Self-reported)	0.2	0.7	1.3	1.1	1.2	-0.6	0.7	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.7	4.3	7.7	-2.7	-2.5	-0.3	-2.8	-0.1
Illnesses of father: Heart disease	1.2	1.7	3.2	-1.8	-1.6	1.5	-0.6	0.5
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.3	-0.2	0.0	0.5	0.6
Smoking status: Previous	0.9	1.4	3.0	0.1	0.5	-1.1	-1.7	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.6	-0.3	-0.4	0.7	0.8	0.8
Whole body fat-free mass	1.7	9.7	21.7	-4.7	-4.5	1.2	-1.9	1.4
Leg fat-free mass (right)	1.5	7.9	17.4	-4.2	-3.9	1.1	-2.3	0.7
Arm fat percentage (left)	1.8	7.1	14.4	-3.8	-3.1	-0.5	-3.3	-0.7
Average weekly red wine intake	1.0	1.5	2.5	-1.4	-1.6	1.5	-0.5	0.7
Handedness (chirality/laterality): Left-handed	2.1	2.5	5.3	1.7	1.4	-0.8	2.3	1.4
Mood swings	0.7	1.3	2.8	-1.3	-1.2	-0.7	-1.7	0.1
Loneliness, isolation	1.5	2.0	4.5	0.5	1.0	-1.1	-1.8	-2.1
Long-standing illness, disability or infirmity	1.7	2.5	6.2	0.5	1.1	-1.1	-2.0	-2.5
Ever had bowel cancer screening	0.5	0.6	1.1	-1.0	-0.7	-1.1	-0.5	-0.0
Diabetes diagnosed by doctor	0.1	0.1	0.4	-0.6	-0.3	0.1	-0.5	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.8	-1.2	-1.5	0.6	0.4	1.7
Friendships satisfaction	2.6	3.3	4.9	2.2	2.1	-1.3	2.1	0.9
Qualifications: nursing, teaching	1.1	1.7	4.0	-2.0	-2.0	0.2	-0.6	0.6
Commuting to job workplace: Walk	1.2	1.3	2.4	-0.6	-1.0	1.5	0.8	1.5
Eye problems/disorders: Cataract	0.5	0.6	1.3	1.1	0.7	0.9	0.8	0.0
Mouth/teeth dental problems: Mouth ulcers	2.1	3.4	8.1	0.8	-0.2	1.3	2.6	2.8
Medication for cholesterol	0.6	0.9	1.7	-1.3	-0.9	0.8	-0.9	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.0	0.8	0.9	-0.4	-0.2	-1.0
Back pain experienced in last month	0.2	0.3	0.6	0.2	0.5	0.5	-0.6	-0.8
Mineral and other dietary supplements	1.0	1.4	3.1	-1.6	-1.8	0.4	-1.0	0.0
Breast cancer (self-reported)	1.0	1.2	2.0	0.7	0.3	1.4	1.2	1.3
Asthma (self-reported)	1.2	2.4	5.6	1.6	2.4	-1.3	-0.1	-1.5
Osteoporosis (self-reported)	0.1	0.1	0.3	-0.1	0.0	-0.4	-0.5	-0.5
Osteoarthritis (self-reported)	0.5	0.7	1.5	0.6	0.4	1.2	0.7	1.0
Medication: Aspirin	1.7	2.3	3.5	0.9	1.4	-1.9	-1.3	-1.9
Medication: Gliclazide	1.7	1.9	2.9	-1.7	-1.6	1.6	-0.0	1.1
Illnesses of father: None of the above (group 1)	0.2	0.2	0.8	-0.0	-0.3	-0.9	-0.2	-0.3
Smoking status: Current	1.6	2.5	4.9	-0.4	0.2	-1.8	-2.2	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.7	5.8	9.9	-2.5	-3.1	2.6	0.2	2.5
Whole body water mass	1.8	10.0	22.3	-4.7	-4.5	1.2	-1.9	1.4
Leg predicted mass (right)	1.5	7.8	17.2	-4.2	-3.9	1.1	-2.3	0.7
Arm fat mass (left)	2.3	9.6	21.3	-4.6	-3.9	-0.1	-3.4	-0.5
Number of self-reported non-cancer illnesses	0.5	0.9	1.5	-0.0	0.5	-1.1	-1.2	-1.2
Average weekly champagne plus white wine intake	1.5	2.1	3.1	-1.1	-1.7	1.5	0.8	1.8
Miserableness	2.7	4.6	10.8	-0.8	-0.0	-2.1	-3.3	-2.7
Guilty feelings	0.3	0.4	0.6	0.7	0.7	-0.2	-0.7	-0.7
Wears glasses or contact lenses	0.1	0.1	0.2	0.1	-0.0	0.3	-0.4	-0.4
Ever taken oral contraceptive pill	0.6	0.7	1.7	0.8	0.7	0.4	1.3	0.5
Hearing aid user	0.6	0.6	1.1	1.1	1.1	-0.3	0.8	-0.3
Mother’s age at death	0.3	0.3	1.0	-0.2	-0.1	0.4	1.0	0.7
Financial situation satisfaction	2.0	2.5	6.0	1.6	1.9	-2.4	0.1	-0.8
Tinnitus: Yes, now most or all of the time	2.4	2.8	6.2	1.9	2.5	-0.8	-0.2	-1.9
Commuting to job workplace: Public transport	0.7	0.8	1.9	-1.4	-1.1	0.6	-0.8	-0.3
Eye problems/disorders: Glaucoma	0.2	0.3	0.7	-0.2	-0.2	-0.1	-0.7	-0.8
Medication: Blood pressure	0.3	0.6	1.0	1.0	0.7	-0.8	0.6	0.6
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.0	-0.7	-0.8	0.6	-1.0	-0.0
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.2	1.5	1.5	-0.8	0.7	0.0
High cholesterol (Self-reported)	0.4	0.6	2.2	-0.6	-0.4	-1.5	-0.7	-0.3
Medication: Bendroflumethiazide	0.3	0.5	1.2	1.1	1.0	-0.4	-0.1	-0.4
Medication: Paracetamol	2.7	4.2	7.3	2.4	2.7	-1.2	-0.5	-2.5
Medication: Lisinopril	0.2	0.2	0.7	-0.0	0.0	0.3	0.5	0.8
Medication: Atorvastatin	0.5	0.6	1.5	-0.4	-0.1	-0.7	-1.2	-1.1
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.5	0.2
Alcohol drinker status: Never	0.5	0.6	1.4	-1.0	-1.2	0.7	-0.1	0.2
Ever smoked	2.3	4.1	8.3	-1.0	-0.4	-2.7	-2.9	-2.0
Basal metabolic rate	1.9	10.5	23.8	-4.9	-4.6	1.0	-2.1	1.2
Leg fat percentage (left)	2.3	8.4	16.5	-4.1	-3.1	-1.0	-3.7	-1.2
Arm fat-free mass (left)	1.9	9.8	22.3	-4.7	-4.5	1.0	-2.1	1.0
Number of operations (self-reported)	1.4	2.1	4.4	-1.8	-2.1	0.6	-1.5	0.5
Average weekly beer plus cider intake	0.3	0.4	0.6	0.4	0.8	-0.4	-0.6	-0.7
Irritability	0.2	0.3	0.8	-0.5	-0.2	-0.9	-0.7	0.2
Risk taking	2.7	3.9	10.7	1.7	1.2	1.1	3.3	1.9
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.8	-1.1	-1.0	-1.4	-0.7	0.2
Fractured/broken bones in last 5 years	2.4	3.0	5.9	1.6	0.8	1.5	2.4	2.0
Age started oral contraceptive pill	1.3	1.6	2.8	-0.5	-0.9	1.6	1.3	1.7
Diastolic blood pressure, automated reading	0.5	1.4	3.3	0.7	1.3	-1.8	-0.6	-1.2
Ever depressed for a whole week	1.0	1.2	3.3	0.6	0.8	-1.8	-0.8	-1.0
Unable to work because of sickness or disability	0.3	0.4	0.8	-0.3	-0.0	-0.6	-0.7	-0.9
Commuting to job workplace: Cycle	2.7	3.3	6.0	-0.3	-0.8	2.3	2.0	2.5
Myopia	0.2	0.4	0.8	0.0	0.2	0.6	-0.8	-0.9
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	-0.8	-0.8	0.2	-0.4	0.2
Cholesterol lowering medication	0.1	0.1	0.2	0.3	0.1	-0.5	-0.3	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.0	-0.5	-0.7	0.0	-1.0	0.5
Pain experienced in last month	1.2	2.0	4.2	-0.4	-0.7	1.3	2.0	1.8
Supplements: Calcium	1.7	1.9	4.5	1.8	2.1	-0.8	0.7	-0.6
Basal cell carcinoma (self-reported)	0.7	0.8	1.4	-1.1	-1.2	0.4	-0.3	1.0
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.2	-1.0	-0.9	0.0	-1.5	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.2	-0.0	-0.3	0.2	0.9	1.1
Heart disease (siblings)	0.7	0.9	1.6	-0.7	-0.9	1.3	0.1	1.2
Alcohol drinker status: Previous	1.3	1.4	3.8	0.1	0.4	-2.0	-0.9	-1.5
Pack years of smoking	1.4	2.0	4.1	0.6	1.0	-1.5	-1.5	-2.0
Impedance of whole body	2.8	14.5	29.6	5.4	5.1	-1.2	3.9	0.1
Leg fat mass (left)	2.9	11.3	24.9	-5.0	-4.1	-0.5	-3.7	-0.6
Arm predicted mass (left)	2.0	10.0	22.8	-4.8	-4.5	1.1	-1.9	1.2