Hub : Genes

DARS2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2370	0.0640	0.0e+00	0.190	0.157	0.173	0.166	0.181	1.2e-22	1.3e-18	1.3e-20	8.8e-20	1.6e-21
2	GTEx	Adipose Visceral Omentum	0.1290	0.0570	1.8e-03	0.004	NA	0.004	NA	0.034	1.8e-01	NA	2.0e-01	NA	7.3e-03
3	GTEx	Artery Coronary	0.1340	0.0660	1.6e-03	0.061	NA	0.107	NA	0.060	4.2e-03	NA	1.9e-04	NA	4.5e-03
4	GTEx	Artery Tibial	0.0554	0.0309	4.8e-03	0.015	NA	0.013	NA	0.007	2.0e-02	NA	3.3e-02	NA	8.2e-02
5	GTEx	Brain Caudate basal ganglia	0.1920	0.0920	8.4e-04	0.018	NA	0.121	NA	0.133	1.0e-01	NA	2.5e-04	NA	1.2e-04
6	GTEx	Brain Putamen basal ganglia	0.1310	0.0590	2.0e-03	0.010	NA	-0.002	NA	-0.003	1.8e-01	NA	3.7e-01	NA	3.9e-01
7	GTEx	Cells EBV-transformed lymphocytes	0.1390	0.0770	7.8e-03	0.003	NA	-0.005	NA	0.002	2.6e-01	NA	4.9e-01	NA	2.7e-01
8	GTEx	Cells Transformed fibroblasts	0.1180	0.0490	5.5e-05	0.016	NA	0.023	NA	0.022	2.0e-02	NA	7.3e-03	NA	8.5e-03
9	GTEx	Esophagus Muscularis	0.1140	0.0460	1.2e-05	0.115	NA	0.106	NA	0.115	1.7e-07	NA	5.6e-07	NA	1.8e-07
10	GTEx	Heart Atrial Appendage	0.1040	0.0480	1.2e-03	0.086	NA	0.070	NA	0.093	1.1e-04	NA	4.5e-04	NA	5.7e-05
11	GTEx	Heart Left Ventricle	0.1912	0.0564	1.2e-07	0.136	NA	0.089	NA	0.152	1.0e-07	NA	1.7e-05	NA	1.8e-08
12	GTEx	Muscle Skeletal	0.1148	0.0400	8.3e-08	0.106	NA	0.107	NA	0.121	1.5e-10	NA	1.2e-10	NA	7.1e-12
13	METSIM	Adipose	0.0421	0.0181	5.0e-05	0.014	0.027	0.016	0.027	0.012	3.0e-03	4.6e-05	1.7e-03	5.2e-05	6.1e-03
14	YFS	Blood	0.0687	0.0253	2.1e-11	0.024	0.040	0.039	NA	0.039	1.9e-08	5.6e-13	7.6e-13	NA	8.6e-13
15	TCGA	Breast Invasive Carcinoma	0.0436	0.0249	2.3e-03	0.001	0.014	0.012	NA	0.011	1.8e-01	5.9e-04	1.4e-03	NA	1.6e-03
16	TCGA	Cervical Squamous Cell Carcinoma	0.1450	0.0790	4.7e-03	0.002	0.012	0.007	NA	0.005	2.4e-01	8.2e-02	1.3e-01	NA	1.8e-01
17	TCGA	Brain Lower Grade Glioma	0.2444	0.0945	3.4e-12	0.112	0.096	0.111	NA	0.119	1.2e-12	5.0e-11	1.3e-12	NA	2.1e-13
18	TCGA	Lung Adenocarcinoma	0.0388	0.0229	4.4e-03	0.008	0.008	-0.001	NA	0.008	3.1e-02	3.6e-02	4.2e-01	NA	3.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Bipolar Disorder (2018)	0.6	0.9	4.9	-1.1	0.4	1.4	0.2	-1.7	-2.2	-0.3	-0.3	-0.5	-0.7	-0.2	-0.7	1.3	0.8	-0.0	-0.7	-0.4	1.1
Bipolar Disorder or Schizophrenia	1.6	3.8	12.7	1.4	2.6	3.6	2.3	-0.2	-1.3	2.2	2.4	1.6	1.5	2.1	1.5	2.9	1.9	0.5	-1.0	1.4	-1.5
Depressed Affect (Nagel 2018)	1.6	3.4	18.6	2.0	0.1	-0.4	0.8	4.3	4.2	-0.5	0.6	1.6	1.7	1.4	1.8	-1.6	0.4	0.9	1.4	1.4	-1.4
Depression (Nagel 2018)	0.9	1.3	8.2	1.1	-0.7	-0.2	1.0	2.1	2.9	-0.7	0.3	1.1	1.0	1.1	1.0	-1.2	-0.1	0.1	0.8	0.7	-1.0
Intelligence (Savage-Jansen 2018)	1.6	5.0	25.8	-2.0	0.4	0.5	-1.3	-2.4	-5.1	-2.4	-1.0	-2.1	-2.1	-1.5	-2.2	0.2	-1.1	3.2	2.3	-1.8	3.0
Neuroticism (Nagel 2018)	1.4	3.2	21.2	1.9	-0.4	-0.9	1.2	4.1	4.6	-0.6	-0.4	1.3	1.4	1.1	1.6	-1.3	0.6	0.3	1.0	1.2	-1.3
Schizophrenia (2018)	2.9	6.1	12.0	2.7	3.0	3.5	2.9	1.1	0.1	3.1	3.3	2.5	2.4	2.8	2.5	2.7	1.9	0.7	-0.8	2.1	-2.9
Schizophrenia vs Biploar Disorder	9.1	12.0	27.5	4.3	3.2	2.7	3.6	4.3	3.3	2.7	3.6	3.8	4.0	3.2	4.1	2.7	3.5	-0.7	-1.1	3.3	-5.2
Worry (Nagel 2018)	2.1	4.3	24.5	2.5	0.1	-0.6	2.0	3.6	5.0	0.2	0.3	1.9	2.0	1.5	2.2	0.0	1.2	-1.2	-0.6	1.6	-3.0
Alzheimer’s Disease (in mother)	0.7	0.8	4.8	0.8	0.8	1.0	1.3	0.7	0.5	2.2	-0.3	0.8	0.7	0.7	0.7	1.0	0.5	0.9	0.3	0.6	-0.5
Alzheimer’s Disease (in father)	1.0	1.1	2.5	1.1	0.9	0.8	1.6	0.7	1.0	1.4	0.8	1.2	1.1	1.4	1.2	0.7	1.0	-0.2	-1.1	1.2	-0.8
Alzheimer’s Disease (including proxy)	0.8	1.2	5.8	0.9	1.0	1.1	1.8	1.1	0.6	2.4	0.2	0.9	0.9	0.9	0.9	0.9	0.7	1.1	0.3	0.8	-0.7
Crohns Disease (2017)	0.6	1.3	3.1	-1.7	-0.5	-0.6	0.4	-1.1	-1.8	-0.8	-0.5	-1.4	-1.5	-1.6	-1.5	-0.6	-0.1	0.9	1.1	-1.7	0.8
Irritable Bowel Disease (IBD)	0.2	0.5	2.4	-0.7	0.2	-0.2	1.6	-0.0	-0.8	0.1	0.0	-0.5	-0.6	-1.0	-0.6	0.1	1.0	0.7	0.9	-0.8	0.0
Ulcerative Colitis (UC)	0.3	0.5	3.8	0.3	0.9	0.2	1.9	0.7	0.0	0.6	0.7	0.4	0.4	-0.1	0.4	0.6	1.6	0.2	0.0	0.2	-0.6
Major Depression (MDD)	0.5	0.6	2.0	1.0	0.9	0.9	0.9	0.8	0.2	0.3	0.3	0.8	0.8	0.3	0.7	0.3	0.4	1.4	0.9	0.6	-0.7
Reaction Time	1.8	3.4	11.4	1.2	3.4	2.6	2.1	1.4	-0.8	1.0	1.5	1.4	1.4	1.6	1.4	3.2	2.7	1.0	-0.8	1.7	-0.6
Verbal and Numeric Reasoning (VNR)	0.6	1.3	8.9	-1.1	0.7	0.1	-0.4	-1.2	-3.0	-0.8	-0.8	-1.1	-1.2	-1.2	-1.2	0.8	0.5	1.3	0.8	-0.7	1.1
Breast Cancer	0.3	0.7	3.9	0.1	0.3	2.0	1.0	-0.9	-0.3	-0.7	1.3	0.6	0.5	1.5	0.4	0.9	0.1	0.0	-0.5	0.4	0.1
Ovarian Cancer	0.7	0.9	2.3	-0.8	-0.5	0.3	-0.8	-0.9	-1.4	-1.4	-0.0	-0.8	-0.8	-0.6	-0.9	-1.1	-0.8	1.0	1.4	-0.8	1.5
Prostate Cancer	1.3	1.8	3.9	1.5	2.0	1.5	1.4	1.1	0.1	0.8	1.9	1.4	1.4	1.8	1.4	1.2	1.7	0.3	-0.3	1.5	-0.5
Age at First Birth	0.3	0.5	1.9	-0.5	-0.3	-0.8	0.0	-0.0	-0.9	0.2	-1.0	-0.6	-0.6	-0.4	-0.6	-0.5	-0.4	0.8	1.1	-0.6	1.4
Bipolar Disorder (2011)	1.3	1.3	5.0	-0.8	0.4	1.2	-0.6	-2.2	-2.1	-1.5	-0.4	-0.3	-0.4	-0.2	-0.5	0.3	-0.3	-1.3	-1.9	-0.1	1.5
Body Mass Index (BMI) (2010)	0.4	0.6	2.2	0.5	1.0	1.0	1.0	0.7	-0.7	1.5	0.4	0.7	0.6	0.5	0.6	0.7	0.7	0.8	-0.2	0.8	-0.1
Coronary Artery Disease (CAD)	1.3	1.6	2.8	-1.5	-1.2	-1.2	-1.3	-0.3	-1.1	-1.3	-0.3	-1.6	-1.7	-1.4	-1.6	-1.7	-1.4	0.3	1.1	-1.4	0.7
Crohns Disease (2012)	0.4	0.6	1.3	-1.1	-0.1	-0.4	0.9	-0.5	-0.9	-1.0	-0.2	-0.9	-0.9	-1.1	-1.0	-0.6	0.2	1.1	0.6	-1.2	0.4
Mean Putamen Volume	1.1	1.3	5.8	1.3	0.6	-0.8	0.1	2.4	0.9	-0.0	-0.4	0.7	1.0	-0.1	0.9	-1.0	0.3	2.4	2.1	0.7	0.3
Fasting Glucose	0.5	0.6	2.2	0.5	0.6	0.5	-0.1	0.6	0.7	-0.3	-0.3	0.3	0.4	0.2	0.5	1.3	1.5	-0.8	-1.4	1.0	-0.2
HbA1C	0.6	0.7	2.4	-0.6	-0.5	-0.2	-1.4	0.4	-0.6	-0.6	0.2	-0.5	-0.5	-0.3	-0.6	-1.2	-1.5	1.1	0.9	-0.5	1.3
HDL Cholesterol	0.8	1.3	11.2	0.1	-0.8	0.1	-1.2	-0.3	1.4	-3.3	-0.8	0.2	0.2	0.3	0.2	-0.4	-1.0	-1.8	-1.4	0.1	-0.4
LDL Cholesterol	1.4	2.2	5.2	1.4	2.3	1.7	1.4	-0.3	-0.9	1.9	1.5	1.5	1.4	1.3	1.4	2.1	1.6	-0.5	-1.6	1.9	-0.2
Lupus	0.6	0.9	3.8	0.7	-1.4	-1.2	-1.0	0.5	1.6	-0.3	-1.9	-0.2	-0.1	0.4	0.0	-1.2	-1.4	-0.4	0.6	0.2	0.8
Neuroticism (2016)	1.3	1.9	7.9	1.8	0.3	0.0	0.6	2.8	2.7	-0.3	0.8	1.4	1.6	1.4	1.6	-0.9	0.3	0.5	0.6	1.5	-1.0
Primary Biliary Cirrhosis	0.4	0.5	3.0	0.2	-0.1	-0.4	-0.3	0.6	1.2	0.1	-1.2	0.3	0.4	-0.2	0.4	0.2	-0.1	-1.7	-1.4	0.5	-0.5
Rheumatoid Arthritis	2.6	3.6	6.4	2.5	2.2	1.7	0.5	1.7	2.0	0.6	1.4	2.4	2.4	2.4	2.4	1.2	1.3	-1.0	-1.8	2.4	-2.0
Schizophrenia (2014)	4.7	10.3	15.8	3.5	3.8	4.0	3.6	1.9	1.1	3.6	3.9	3.5	3.5	3.4	3.5	3.5	2.8	-0.2	-2.0	3.3	-3.9
Triglycerides	0.6	1.1	6.9	0.2	0.1	1.2	1.8	-0.1	-0.4	2.6	1.4	0.2	0.1	0.4	0.1	1.2	1.3	-0.1	0.1	-0.1	-1.4
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.4	-1.0	-0.9	-0.3	0.5	-1.1	-0.3	-0.1	0.3	-0.7	-0.7	-0.7	-0.7	-0.4	-0.3	-0.7	0.3	-1.2	-0.6
Ulcerative Colitis	2.4	3.4	7.4	2.0	2.3	1.2	2.7	2.1	1.6	2.2	1.5	2.0	2.1	1.3	2.1	1.4	2.7	0.0	-0.7	2.0	-1.1
Blood Eosinophil Count	0.3	2.5	15.1	0.2	0.7	0.3	0.6	1.5	2.3	0.8	0.6	0.7	0.6	0.6	0.8	1.9	1.1	-3.9	-2.5	0.4	-2.8
Blood Platelet Count	0.3	3.3	7.7	0.5	2.4	0.6	2.0	2.0	1.1	2.6	2.1	1.0	1.0	0.4	1.1	2.5	2.7	-1.8	-2.1	0.9	-2.8
Blood Red Count	2.6	25.1	44.9	6.1	4.3	1.8	5.2	6.7	6.6	3.5	3.7	5.9	6.2	5.6	6.2	3.1	5.0	-2.0	-3.0	6.0	-4.8
Blood White Count	1.3	9.8	26.0	2.9	3.9	3.5	3.4	3.9	1.5	2.8	5.1	3.0	3.0	2.5	3.1	2.8	3.8	0.6	-0.1	2.5	-4.0
Heel T-Score	1.5	11.6	46.2	4.6	3.0	0.8	2.3	6.8	3.5	2.1	2.5	3.7	4.0	3.5	4.0	-1.4	1.0	4.1	3.6	3.3	-1.5
BMI	1.7	9.7	42.5	-1.1	-0.2	-2.9	-1.6	1.9	-3.0	-1.3	0.5	-1.8	-1.7	-1.7	-1.8	-5.1	-2.6	6.5	6.5	-1.8	3.9
Height	0.5	9.9	30.1	-4.3	-2.0	0.4	-3.2	-5.5	-3.7	-2.3	-3.0	-3.2	-3.7	-2.5	-3.6	1.1	-2.2	-3.9	-3.7	-2.9	1.3
Waist Hip Ratio (WHR)	0.7	3.0	13.0	2.4	1.1	0.3	0.7	3.6	2.2	1.4	0.3	1.7	1.9	1.3	2.0	-0.0	0.5	2.5	2.1	1.5	-1.4
Systolic Blood Pressure	0.5	2.4	6.4	0.9	1.4	1.7	1.2	1.1	1.5	0.2	2.5	1.2	1.1	1.4	1.2	1.7	1.7	-2.3	-2.0	1.1	-2.2
Smoking Status	1.1	2.7	10.2	1.8	-0.2	0.9	1.7	3.2	3.1	-0.0	1.2	1.7	1.6	1.5	1.6	-0.8	0.4	0.8	1.4	1.0	-2.3
Allergy or Eczema	0.4	1.1	6.5	-0.3	-0.7	0.3	1.0	-1.6	0.6	0.2	-0.2	-0.1	-0.1	-0.1	-0.1	1.5	1.1	-2.5	-1.9	-0.1	-1.1
Cardiovascular Disease	0.1	0.3	1.0	-0.3	0.5	0.7	0.0	-0.0	-0.8	-0.5	1.0	-0.2	-0.2	0.0	-0.3	-0.3	0.4	1.0	0.5	-0.3	0.4
Hypothyroidism (self reported)	2.4	5.6	11.7	2.2	3.4	2.3	1.2	1.9	1.0	2.6	3.4	2.3	2.3	2.5	2.4	2.8	2.1	-1.2	-2.0	2.3	-3.0
Respiratory disease	2.6	5.8	17.8	1.7	1.2	1.4	3.4	2.4	3.7	-0.2	2.2	2.1	2.0	2.3	2.1	2.2	3.1	-2.4	-1.9	1.6	-4.2
Type 2 Diabetes (T2D) (2018)	0.5	1.0	5.0	0.1	0.7	0.6	0.7	1.4	-0.6	0.6	2.1	-0.2	-0.1	-0.1	-0.1	-0.8	0.7	1.6	2.2	-0.4	-0.4
Lung FEV1/FVC ratio	0.1	0.7	4.2	0.3	-0.3	-0.6	-0.8	-0.1	-0.2	-0.9	-0.8	0.3	0.4	0.3	0.3	-1.4	-0.9	1.2	0.7	0.5	2.0
Lung FVC	2.6	13.4	21.9	-3.5	-3.6	-4.2	-4.7	-3.3	-2.4	-2.8	-3.9	-4.2	-4.0	-4.4	-4.1	-4.3	-4.0	1.0	1.6	-4.0	3.2
Neuroticism	2.3	5.7	28.1	2.9	0.5	-0.3	2.3	4.6	5.3	0.1	0.6	2.5	2.6	2.2	2.8	-0.1	1.2	-0.5	-0.2	2.4	-2.4
Chronotype (morning person)	0.7	1.7	9.0	-0.4	0.5	1.0	-0.1	-2.3	-1.0	-0.2	0.2	-0.3	-0.3	-0.3	-0.2	2.1	0.8	-2.7	-3.0	0.1	-1.2
Hair Pigment	0.2	5.7	8.9	2.5	2.6	2.6	3.0	2.3	1.9	2.2	2.4	2.5	2.4	2.8	2.5	2.7	2.4	-0.1	-1.1	2.3	-2.9
Tanning	0.0	0.5	1.4	0.9	0.5	0.2	0.7	1.1	0.6	-0.2	-0.1	0.8	0.8	0.3	0.9	0.5	0.0	-0.6	-0.9	0.8	-1.2
Hand grip strength (left)	0.3	0.8	5.4	0.4	0.5	0.7	2.3	-0.2	0.3	0.2	0.9	0.8	0.7	0.8	0.7	0.8	0.8	-0.8	-0.9	0.4	-1.4
Number of treatments/medications taken	3.2	5.8	21.3	2.8	0.5	1.2	2.6	3.0	4.6	1.2	2.0	2.7	2.7	3.1	2.8	0.6	1.9	-1.0	-1.1	2.5	-2.6
Average weekly spirits intake	0.7	0.9	3.2	0.4	-0.9	-1.8	-0.4	1.1	1.2	-1.5	-1.4	0.1	0.2	-0.1	0.2	-1.6	-0.6	0.5	0.5	0.3	0.8
Sensitivity / hurt feelings	0.8	1.3	4.2	-0.5	-1.5	-1.9	-0.3	1.1	1.2	-2.1	-1.4	-1.1	-0.9	-1.1	-0.8	-1.5	-0.5	0.3	0.9	-0.7	0.9
Frequency of depressed mood in last 2 weeks	0.9	1.2	5.1	1.3	0.1	0.4	0.7	2.0	2.3	-0.8	0.8	1.3	1.3	1.2	1.3	-0.7	-0.0	-0.2	0.3	1.0	-1.0
Hearing difficulty/problems: Yes	2.1	3.3	6.5	2.0	1.8	1.7	2.1	1.6	1.0	0.8	2.4	2.1	2.0	2.1	2.1	1.6	1.6	-0.4	-1.1	1.9	-2.5
Relative age of first facial hair	1.6	3.4	14.6	-1.4	0.6	-0.4	-1.2	-1.8	-3.8	-1.3	-0.8	-1.7	-1.6	-2.0	-1.7	0.1	-0.6	3.2	2.0	-1.2	2.9
Other serious medical condition/disability diagnosed by doctor	1.0	1.4	9.9	0.7	0.9	-0.3	-0.2	1.0	-0.4	0.4	1.4	0.5	0.6	0.2	0.5	-1.3	-0.5	3.1	2.5	0.2	0.7
Ever used hormone-replacement therapy (HRT)	2.6	3.3	10.2	-2.2	-3.2	-1.6	-1.5	-1.6	0.7	-0.9	-2.3	-1.9	-2.0	-2.3	-2.0	-2.0	-1.5	-1.6	-0.5	-2.1	0.7
Ever had hysterectomy (womb removed)	0.8	0.9	5.8	-0.0	-1.6	-1.1	-0.2	0.9	2.4	-0.7	-0.2	0.0	0.0	-0.2	0.0	-1.8	-0.7	-0.8	0.3	-0.4	-0.7
Systolic blood pressure, automated reading	0.5	1.4	4.7	1.3	0.7	0.7	0.5	1.6	1.9	-0.6	2.2	1.2	1.3	1.5	1.3	0.1	0.6	-0.8	-0.7	1.4	-0.7
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.3	-1.1	-0.5	-0.3	0.2	-0.6	-1.5	0.6	1.0	-1.1	-1.1	-0.4	-1.1	-0.9	-0.7	1.0	1.8	-1.5	0.8
Angina	0.2	0.2	1.0	0.6	0.0	0.1	0.1	0.5	1.0	-0.1	-0.3	0.6	0.6	0.5	0.6	-0.4	0.4	-0.3	-0.3	0.4	-0.5
Medication for hormone replacement therapy	0.6	0.7	1.9	-0.9	-1.0	-0.9	-0.8	0.3	0.2	-0.1	-0.0	-1.0	-0.9	-1.0	-0.9	-1.4	-1.1	0.6	0.8	-0.9	0.5
Vitamin and mineral supplements	1.8	2.5	8.0	-1.0	-1.1	-1.8	-1.8	0.1	-0.8	-0.8	-1.4	-1.4	-1.2	-1.3	-1.2	-2.8	-1.7	2.0	2.1	-1.2	2.4
Supplements: Zinc	1.2	1.3	4.5	1.0	1.4	1.8	1.3	0.7	0.0	0.2	0.5	1.1	1.0	0.9	1.0	2.1	1.6	-0.2	-1.0	1.3	-1.0
Medication: Co-codamol	1.1	1.3	6.2	0.9	-0.9	-1.4	-0.8	2.0	2.5	0.4	-0.9	0.5	0.6	0.2	0.7	-1.4	-1.4	0.7	1.1	0.5	0.6
Medication: Metformin	0.8	1.2	3.7	-0.8	0.1	0.0	-0.8	-1.0	-1.9	0.7	1.8	-1.1	-1.1	-1.1	-1.1	-1.1	-0.3	0.8	1.6	-1.1	0.6
Diabetes (father)	0.4	0.5	2.1	-0.5	-1.5	-0.2	-0.1	-0.9	0.5	-0.9	-0.7	-0.4	-0.4	-0.4	-0.4	-0.9	-0.1	-1.2	-0.4	-0.3	0.5
Diabetes (mother)	0.4	0.5	3.0	0.9	0.2	0.0	0.2	1.7	1.0	0.6	0.8	0.5	0.7	0.8	0.7	-0.3	0.4	0.8	0.9	0.6	-0.2
Severe depression (siblings)	0.2	0.3	2.0	0.3	0.5	0.1	0.7	0.1	-0.3	-0.8	1.4	0.2	0.2	0.3	0.2	-0.0	0.6	0.3	0.2	0.0	-0.8
Pack years adult smoking proportion	1.9	2.9	9.6	2.0	1.6	0.1	1.5	3.1	2.8	1.4	1.7	1.7	1.9	1.4	1.9	0.4	1.1	0.3	-0.2	1.6	-2.3
Impedance of leg (right)	0.9	4.4	15.8	0.9	0.9	2.4	2.1	-1.0	1.4	1.1	-0.2	1.4	1.2	1.8	1.2	4.0	1.9	-3.5	-4.0	1.7	-2.0
Leg fat-free mass (left)	1.2	6.2	13.2	-2.3	-1.5	-1.9	-2.8	-0.4	-2.7	-1.4	-1.6	-2.3	-2.3	-2.6	-2.4	-3.4	-2.8	3.0	3.6	-2.6	3.0
Trunk fat percentage	0.7	2.7	14.7	1.6	1.5	0.1	0.5	2.7	-0.2	1.5	1.0	1.2	1.2	1.2	1.2	-1.4	-0.4	3.8	2.9	1.1	1.0
Hand grip strength (right)	0.2	0.6	4.0	0.3	0.4	0.5	2.0	-0.5	-0.3	-0.1	0.9	0.7	0.6	0.7	0.5	0.5	1.2	-0.6	-0.3	0.4	-0.7
Townsend deprivation index at recruitment	0.9	1.3	3.8	1.0	1.3	1.4	1.2	1.3	0.7	-0.0	1.7	0.9	0.9	1.0	1.0	1.2	1.3	-0.4	-0.7	0.8	-2.0
Current tobacco smoking	0.7	1.1	4.8	1.2	0.8	0.3	0.7	2.2	1.1	0.3	0.6	0.9	0.9	0.4	0.9	-0.9	0.8	1.7	1.4	0.5	-1.1
Average weekly fortified wine intake	0.8	0.9	3.3	-0.4	-1.2	-1.6	-0.8	0.3	1.0	-0.9	-1.2	-0.7	-0.5	-0.7	-0.6	-1.8	-0.9	0.6	0.9	-0.6	1.1
Maternal smoking around birth	0.6	0.8	6.7	0.5	0.1	-0.8	0.7	2.6	1.8	0.4	0.1	0.5	0.5	0.6	0.6	-0.6	0.1	0.8	1.1	0.5	-0.1
Fed-up feelings	0.9	1.7	8.8	0.9	-0.5	-0.5	0.3	3.0	2.7	-0.8	0.6	0.4	0.5	0.5	0.5	-2.1	-0.3	1.3	2.0	0.1	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	7.3	1.4	0.2	-0.1	1.1	2.5	2.7	-0.1	1.2	1.3	1.4	1.1	1.4	-0.6	0.5	-0.3	0.2	1.1	-1.4
Relative age voice broke	1.2	1.8	13.7	-0.1	1.0	-0.9	-0.4	0.8	-1.9	-1.2	-0.1	-0.4	-0.3	-0.6	-0.4	-1.1	-0.9	3.7	2.4	-0.2	1.9
Taking other prescription medications	2.2	3.3	11.4	2.2	0.6	0.5	1.9	3.0	3.4	1.6	1.8	1.9	2.0	2.1	2.0	-0.2	1.1	0.7	1.0	1.5	-1.8
Age when periods started (menarche)	2.9	7.1	16.4	-2.4	-3.1	-3.5	-3.4	-2.4	-0.7	-1.7	-4.1	-2.7	-2.5	-3.2	-2.5	-2.7	-3.0	-0.1	0.4	-2.0	3.5
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	8.0	-0.2	-1.6	-1.3	-1.7	0.8	2.0	0.3	-1.0	-0.4	-0.3	-1.1	-0.3	-2.8	-1.4	0.9	1.2	-0.5	0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	15.5	0.8	0.8	-0.2	-0.2	2.3	-0.7	-0.2	0.8	0.3	0.5	0.1	0.4	-2.0	-0.4	3.9	3.8	-0.1	0.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.3	-0.8	-0.4	-0.6	-1.1	-0.3	-0.5	-1.5	-0.3	-1.0	-1.0	-0.5	-1.0	-0.2	-1.3	-0.1	0.5	-1.0	0.6
Qualifications: CSEs or equivalent	1.5	2.0	4.4	1.7	1.5	0.8	1.2	2.0	1.5	0.9	1.4	1.7	1.8	2.1	1.8	0.1	0.8	1.1	0.4	1.8	-0.0
Serious illness, injury or assault to yourself	0.5	0.6	3.9	-0.0	0.1	-0.3	-1.4	0.2	0.8	-0.8	-0.0	0.0	0.1	0.4	0.1	0.1	-0.5	-1.7	-2.0	0.4	0.1
High blood pressure	0.2	0.6	5.0	0.5	1.2	1.0	0.0	0.3	-0.1	0.2	2.2	0.6	0.6	0.9	0.6	0.1	-0.1	0.3	-0.5	0.6	-0.1
Hayfever, allergic rhinitis or eczema	0.5	1.0	4.9	-0.8	-0.9	0.5	0.4	-2.2	-0.3	-0.6	-0.9	-0.4	-0.4	-0.6	-0.5	1.4	0.7	-2.0	-1.4	-0.5	-0.5
Multivitamins +/- minerals	1.1	1.4	4.9	0.3	0.9	1.1	1.5	-0.5	-0.2	0.9	1.4	0.6	0.4	0.6	0.5	2.2	1.4	-1.5	-1.6	0.5	-2.0
Stomach or abdominal pain in last month	0.9	1.1	2.7	-1.1	-0.4	0.3	-0.7	-0.9	-1.7	-0.7	1.1	-1.0	-1.1	-1.0	-1.1	-1.0	-1.3	1.3	1.4	-1.3	0.2
Supplements: Glucosamine	1.0	1.4	5.9	-0.6	-1.9	-1.3	-0.9	-0.2	1.6	-2.4	-1.3	-0.5	-0.5	-0.9	-0.5	-1.0	-0.1	-2.1	-0.8	-0.4	0.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.5	-0.6	-0.9	-0.9	-0.6	0.8	0.5	-0.9	-0.7	-0.8	-0.7	-1.1	-0.6	-0.9	-1.2	-0.4	0.1	-0.7	-0.2
Medication: Atenolol	0.8	1.0	2.8	-0.0	-1.4	-0.7	-0.4	0.9	1.7	-1.3	-1.4	-0.0	0.1	-0.0	0.1	-1.6	-1.0	0.5	0.8	0.2	1.6
Medication: Levothyroxine sodium	1.1	1.9	5.3	1.5	2.3	1.1	0.5	1.7	0.1	2.0	2.3	1.3	1.4	1.2	1.4	0.7	1.0	1.6	0.6	1.2	-1.1
Sitting height	0.2	1.5	6.2	-1.4	0.4	0.9	-0.6	-2.1	-2.5	1.0	0.4	-0.8	-1.1	-1.1	-1.1	1.2	0.5	-1.4	-1.0	-1.2	-0.7
Chronic bronchitis/emphysema (father)	0.8	1.0	4.8	0.8	0.3	-0.1	0.0	2.2	1.2	-1.4	1.4	0.3	0.4	0.3	0.4	-1.1	-0.3	1.0	1.4	0.0	-1.3
High blood pressure (mother)	1.1	1.6	2.9	1.2	0.8	1.7	0.5	1.0	1.6	0.2	1.3	1.6	1.5	1.6	1.5	1.2	1.0	-1.3	-1.1	1.3	-1.3
Body mass index (BMI)	1.5	6.3	35.0	0.2	0.2	-1.7	-1.4	2.0	-1.7	0.0	0.7	-0.5	-0.3	-0.4	-0.4	-4.3	-2.3	5.9	5.5	-0.7	3.4
Impedance of leg (left)	1.3	6.4	21.3	1.5	1.5	2.5	2.6	-0.6	1.8	1.7	-0.1	1.8	1.7	2.1	1.8	4.5	2.8	-3.9	-4.6	2.2	-2.9
Leg predicted mass (left)	1.1	5.8	12.4	-2.2	-1.4	-1.8	-2.6	-0.4	-2.7	-1.3	-1.5	-2.2	-2.3	-2.5	-2.3	-3.3	-2.7	3.0	3.5	-2.5	2.9
Trunk fat mass	0.7	2.9	19.0	0.6	0.8	-0.4	-0.6	1.9	-1.3	0.8	0.3	0.2	0.2	0.2	0.2	-2.3	-1.3	4.4	3.7	0.1	2.1
Waist circumference	1.2	4.4	26.1	0.7	0.3	-0.8	-1.3	2.3	-0.8	0.1	0.2	0.2	0.3	0.1	0.2	-3.3	-2.1	5.1	4.6	-0.0	2.6
Number of incorrect matches in round	3.0	5.0	9.2	2.1	1.7	2.7	1.7	0.6	1.6	1.7	1.9	2.3	2.2	2.7	2.2	2.9	2.4	-2.2	-2.8	2.2	-3.0
Past tobacco smoking	1.0	1.8	7.5	-1.3	1.0	-0.5	-1.3	-2.6	-2.7	-0.7	-0.4	-1.2	-1.1	-1.3	-1.1	0.9	0.4	-0.7	-1.4	-0.5	1.8
Alcohol usually taken with meals	10.9	17.6	31.2	-5.2	-3.2	-3.4	-4.5	-5.6	-4.9	-2.2	-4.9	-4.9	-4.9	-5.0	-5.0	-2.4	-3.5	0.5	0.7	-4.2	5.3
Nervous feelings	1.6	3.0	11.7	2.1	0.9	-0.2	2.3	2.9	3.4	0.7	0.6	1.7	1.9	1.5	2.0	0.6	1.9	-0.2	-0.4	1.7	-1.7
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	9.7	0.9	-0.9	-0.2	0.9	2.4	3.1	-0.6	0.8	0.9	0.9	0.9	0.9	-1.4	0.1	-0.2	1.3	0.4	-1.5
Hearing difficulty/problems with background noise	1.3	2.1	3.8	1.6	2.0	1.3	1.9	1.8	0.3	1.3	1.9	1.4	1.4	1.3	1.4	1.3	1.6	1.3	0.5	1.2	-1.8
Hair/balding pattern: Pattern 2	0.2	0.3	1.2	-0.4	-1.0	-0.2	-0.0	-1.1	0.1	-0.4	-1.1	-0.4	-0.4	-0.3	-0.4	0.4	0.1	-0.4	-0.3	-0.1	0.4
Had menopause	0.4	0.5	2.9	-0.8	-1.1	-0.2	-0.7	-1.7	-0.7	0.5	-0.1	-0.5	-0.6	-0.2	-0.7	-0.8	-0.1	0.4	0.0	-0.7	1.0
Had other major operations	1.1	1.4	5.0	1.5	0.5	-0.1	0.6	2.2	1.7	-0.3	0.8	1.4	1.4	0.5	1.4	-1.0	0.7	1.3	1.4	1.2	-0.5
Forced vital capacity (FVC)	2.3	9.0	17.3	-3.7	-2.5	-2.5	-3.1	-3.5	-2.9	-1.9	-4.0	-3.8	-3.8	-4.2	-3.8	-1.6	-2.4	-1.0	-0.3	-3.6	1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.1	17.2	1.5	1.1	-0.1	0.3	3.1	-0.1	0.4	1.2	1.0	1.2	0.6	1.1	-1.9	-0.2	4.2	4.0	0.4	0.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	3.1	0.5	0.2	0.4	0.3	1.1	-0.1	-0.2	0.5	0.1	0.2	0.1	0.2	0.2	-0.2	1.3	1.8	-0.2	-0.7
Qualifications: None of the above	2.1	4.5	12.8	2.7	1.8	0.7	1.6	3.6	3.0	0.9	2.1	2.5	2.5	2.4	2.6	0.6	1.7	0.1	-0.6	2.4	-2.4
Financial difficulties in last 2 years	1.2	1.6	3.6	1.3	1.0	0.7	1.9	1.9	1.8	-0.2	1.3	1.4	1.3	1.7	1.4	0.9	1.2	-0.2	-0.4	1.2	-1.4
Mouth/teeth dental problems	0.6	0.9	8.7	-0.6	1.0	0.1	-0.8	-1.3	-3.0	0.7	0.6	-0.5	-0.5	-0.5	-0.6	0.5	-0.5	0.9	0.3	-0.5	0.7
Heart attack	0.2	0.3	1.3	-0.1	-0.1	-0.8	-0.4	0.4	-0.3	-1.0	-0.1	-0.2	-0.2	-0.4	-0.2	-0.9	-0.3	0.8	1.2	-0.5	0.0
Allergy	0.7	1.5	7.5	0.4	0.8	-0.8	-1.1	1.1	-1.2	0.8	-0.0	-0.0	0.1	0.2	0.1	-1.6	-1.5	2.7	1.9	0.3	2.3
Pain all over the body in last month	0.8	0.8	2.2	1.0	-0.1	0.6	1.1	1.3	1.5	0.5	0.7	0.9	0.8	1.5	0.9	0.4	0.9	-0.3	0.1	0.7	-1.3
Diabetes (self-reported)	0.5	0.7	6.0	0.2	0.8	1.0	0.4	0.1	-1.0	0.0	2.4	-0.0	-0.0	0.3	-0.0	-0.5	0.6	1.1	1.4	-0.1	0.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	4.2	0.4	-0.6	-0.6	0.7	1.2	2.1	-0.7	-0.8	0.2	0.3	-0.1	0.3	-0.0	0.6	-1.5	-0.5	-0.2	-1.8
Medication: Ramipril	1.2	1.6	4.1	1.3	1.9	1.0	0.4	1.4	-0.5	1.5	1.9	1.2	1.3	1.4	1.3	0.1	0.3	2.0	1.1	1.2	0.4
Medication: Simvastatin	0.4	0.5	1.0	0.9	0.4	0.6	0.5	0.5	0.7	-0.9	0.5	0.9	0.9	0.9	0.8	-0.2	0.8	0.7	0.2	1.0	0.8
Fluid intelligence score	1.0	2.0	7.5	-1.5	0.1	-0.4	-0.8	-1.0	-2.7	-1.5	-1.1	-1.6	-1.6	-1.7	-1.6	-0.3	-0.5	1.7	1.7	-1.4	1.5
Illnesses of siblings	0.2	0.3	0.8	0.1	0.7	-0.1	0.0	-0.4	-0.7	0.7	-0.8	0.1	0.1	-0.7	0.1	0.7	0.8	-0.5	-0.9	0.1	-0.6
Neuroticism score	2.1	4.3	22.5	2.2	0.4	-0.4	2.2	4.1	4.7	-0.3	0.8	1.8	2.0	1.6	2.1	-0.1	1.4	-0.7	-0.4	1.8	-2.6
Weight	1.3	6.3	18.6	-1.6	-0.8	-1.6	-2.5	-0.1	-3.0	-0.9	-1.0	-1.8	-1.8	-1.8	-1.9	-3.7	-2.9	4.3	4.3	-2.0	3.8
Impedance of arm (right)	1.7	7.7	31.7	1.0	0.8	1.7	2.2	0.3	3.0	0.7	-0.4	1.4	1.3	1.4	1.5	4.5	2.9	-5.5	-5.6	1.8	-4.2
Arm fat percentage (right)	0.9	3.5	18.2	0.1	0.1	-1.5	-1.2	2.0	-1.0	0.1	0.1	-0.6	-0.4	-0.5	-0.5	-3.2	-1.9	4.3	4.0	-0.6	2.2
Trunk fat-free mass	1.9	10.7	17.9	-3.7	-2.3	-1.8	-3.7	-2.6	-4.2	-2.1	-2.4	-3.5	-3.6	-3.5	-3.7	-3.3	-3.6	2.4	3.4	-3.8	3.9
Hip circumference	0.9	4.0	13.4	-1.3	-0.5	-0.6	-2.0	-0.8	-2.9	-1.2	-0.4	-1.2	-1.3	-1.1	-1.4	-2.8	-2.4	3.4	3.0	-1.2	3.7
Time employed in main current job	1.9	2.2	4.6	2.0	1.3	1.1	1.0	2.1	1.9	0.3	0.8	2.0	2.1	2.0	2.1	0.3	0.4	0.3	-0.5	2.0	-0.7
Alcohol intake versus 10 years previously	3.5	5.2	12.0	1.2	2.5	3.2	2.8	-0.6	-0.2	-0.6	3.3	1.8	1.6	2.3	1.6	3.4	3.5	-1.5	-2.9	1.8	-2.1
Father’s age at death	1.1	1.5	4.2	-1.1	-1.9	-0.6	-2.0	-1.1	-0.1	-0.0	-1.8	-1.1	-1.1	-1.2	-1.1	-1.4	-1.6	-0.6	0.3	-1.1	1.2
Worrier / anxious feelings	0.7	1.2	5.8	1.4	0.7	-0.3	1.6	1.8	2.4	0.0	0.1	1.1	1.1	1.1	1.1	-0.0	0.7	-0.2	-0.4	1.1	-1.2
Frequency of tiredness / lethargy in last 2 weeks	3.5	5.7	18.2	2.8	2.0	1.4	2.2	4.3	3.5	0.5	3.0	2.6	2.6	2.2	2.7	0.7	1.6	0.2	-0.0	2.2	-3.3
Falls in the last year	0.2	0.3	1.8	-0.6	-0.7	1.3	0.0	-1.2	-0.5	-0.1	0.1	-0.2	-0.3	0.5	-0.3	0.6	0.3	-0.3	-0.3	-0.3	0.2
Hair/balding pattern: Pattern 3	0.5	0.7	2.5	0.7	1.6	1.2	0.4	-0.1	-0.7	-0.0	1.3	0.7	0.7	1.0	0.7	1.1	0.9	-0.3	-0.8	0.6	-0.7
Number of live births	0.9	1.3	2.4	-1.1	-1.0	-0.4	-1.0	-1.4	-1.4	0.6	-0.4	-1.0	-1.1	-1.0	-1.2	-1.4	-0.7	1.5	1.5	-1.1	1.5
Forced expiratory volume in 1-second (FEV1)	2.3	7.8	17.4	-3.3	-2.4	-2.4	-3.0	-3.1	-2.8	-1.6	-4.2	-3.4	-3.3	-3.7	-3.3	-1.5	-2.6	-0.4	0.2	-3.1	2.3
Pulse rate	0.9	1.5	5.0	1.6	0.4	0.7	1.2	2.0	2.2	0.2	1.0	1.5	1.5	1.0	1.5	-0.6	0.2	0.1	0.6	1.1	-1.5
Happiness	2.1	2.5	4.5	1.8	2.1	1.8	1.9	1.7	0.8	-0.1	1.9	1.7	1.7	1.6	1.7	2.1	1.4	0.4	-0.4	1.7	-1.6
Noisy workplace	0.4	0.5	1.0	-0.4	-0.9	-0.6	-0.4	-0.9	-0.2	0.8	-1.0	-0.8	-0.7	-0.4	-0.7	-0.6	-0.7	0.4	0.8	-0.7	0.6
Qualifications: A levels/AS levels or equivalent	1.4	3.0	7.0	-1.4	-0.9	-1.3	-1.7	-1.7	-2.6	-0.3	-1.8	-1.8	-1.7	-2.4	-1.8	-1.0	-1.1	1.7	2.1	-1.5	2.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	2.9	-0.9	-0.9	-0.3	-0.3	0.9	0.7	-0.4	-1.7	-0.8	-0.8	-1.0	-0.7	-0.3	-0.1	0.2	0.5	-0.7	-0.1
Mouth/teeth dental problems: Dentures	0.9	1.5	9.1	1.3	-0.9	-0.9	0.6	2.2	3.0	0.5	-0.6	0.9	1.0	0.6	1.0	-1.7	0.1	1.0	1.1	0.9	0.0
Asthma	1.2	2.4	10.4	0.9	-0.0	0.6	1.9	1.6	3.1	0.4	0.6	1.2	1.1	1.1	1.1	1.0	1.9	-2.0	-1.1	0.6	-3.2
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	6.4	0.8	-0.4	-0.6	1.2	1.1	2.5	0.6	0.0	0.7	0.7	0.3	0.8	0.2	1.4	-2.1	-1.8	1.0	-1.8
Medication: Cholesterol lowering	0.5	0.8	2.9	1.1	1.4	0.7	1.0	0.6	-0.3	0.4	1.2	0.8	0.9	1.0	0.9	0.5	1.7	1.1	0.2	1.0	-0.1
Depression (self-reported)	1.3	1.6	11.2	1.2	-0.0	-0.9	0.1	2.0	0.8	0.5	-0.2	0.4	0.6	-0.1	0.6	-1.5	-0.1	2.7	3.3	0.1	0.1
Medication: Lansoprazole	1.0	1.2	3.0	-1.1	-1.7	-1.1	-1.3	-0.5	0.4	-0.3	-1.3	-1.0	-1.0	-0.9	-1.0	-1.7	-1.5	0.1	0.2	-0.9	1.4
Prospective memory result	2.5	3.0	17.2	-0.5	-0.1	1.7	1.0	-1.2	0.1	0.0	1.6	0.2	-0.1	0.7	0.0	2.2	1.9	-4.1	-3.4	-0.2	-2.9
Lung cancer (father)	2.4	2.8	8.3	1.2	1.7	2.9	2.3	0.4	-0.2	-0.2	2.4	1.4	1.2	2.1	1.3	2.2	1.9	-0.6	-1.1	1.1	-2.4
Illnesses of mother	0.2	0.2	1.6	0.1	0.3	-0.8	0.1	-0.3	-0.3	-0.5	-1.3	-0.2	-0.1	-0.5	-0.0	0.4	0.4	0.1	-0.5	0.3	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.4	7.5	13.4	-3.0	-2.3	-2.0	-3.4	-3.3	-3.0	-1.7	-3.7	-3.1	-3.1	-3.4	-3.1	-1.9	-3.1	0.0	0.3	-2.9	2.5
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	0.6	0.4	-0.1	-0.7	0.5	0.2	-0.7	0.7	0.6	0.6	0.3	0.5	-0.6	0.3	0.1	0.2	0.5	0.1
Impedance of arm (left)	2.0	9.3	28.9	1.5	1.4	2.3	3.0	0.7	3.1	1.8	0.7	2.0	1.9	2.0	2.0	4.9	3.6	-5.1	-5.4	2.3	-4.7
Arm fat mass (right)	1.2	4.9	22.5	-0.6	-0.3	-1.5	-1.6	1.3	-1.9	-0.3	-0.1	-1.0	-1.0	-0.9	-1.0	-3.7	-2.4	4.7	4.6	-1.2	2.9
Trunk predicted mass	1.9	10.6	17.2	-3.7	-2.3	-1.8	-3.7	-2.7	-4.2	-2.1	-2.4	-3.5	-3.6	-3.5	-3.7	-3.4	-3.6	2.3	3.3	-3.7	3.9
Standing height	0.7	6.8	17.6	-3.7	-2.0	0.2	-2.3	-4.2	-2.9	-1.7	-3.2	-2.7	-3.1	-2.8	-3.1	1.1	-1.2	-3.0	-2.1	-2.8	0.8
Length of working week for main job	0.6	0.6	2.2	-0.2	-0.9	-1.1	0.7	0.9	1.4	-0.4	-0.9	-0.3	-0.3	-0.7	-0.2	-0.2	0.2	-1.5	-0.5	-0.3	-1.2
Exposure to tobacco smoke at home	0.4	0.5	2.3	0.1	-0.4	-0.6	-0.1	1.1	0.6	-0.1	0.1	0.2	0.2	0.3	0.2	-1.5	-0.8	0.9	1.2	0.1	0.8
Breastfed as a baby	1.4	1.8	6.0	-1.0	-0.9	-1.9	-1.4	-0.6	-0.9	0.5	-0.5	-1.0	-0.9	-0.7	-1.0	-2.0	-2.0	1.7	1.5	-0.9	2.5
Tense / ‘highly strung’	3.1	5.2	31.5	2.2	-0.3	-0.5	1.9	3.1	5.6	-1.7	0.2	2.0	2.2	1.5	2.3	0.1	1.4	-2.6	-1.8	1.9	-3.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	8.8	0.2	-1.0	-1.9	0.1	1.9	1.1	-0.2	-0.4	-0.4	-0.3	-0.8	-0.2	-2.0	-0.5	1.9	3.0	-1.1	-0.8
Hair/balding pattern: Pattern 4	1.6	3.8	10.8	2.3	0.7	0.7	2.4	2.2	3.3	0.0	1.4	2.4	2.4	2.4	2.4	0.4	1.4	-1.2	-1.3	2.4	-2.0
Birth weight of first child	1.2	2.2	6.8	-1.8	-1.2	-1.0	-2.0	-2.6	-1.9	-0.5	-0.7	-1.6	-1.6	-1.9	-1.7	-1.2	-1.4	-0.4	-0.2	-1.4	1.4
Peak expiratory flow (PEF)	1.1	2.4	5.2	-1.5	-0.7	-1.7	-1.7	-1.0	-1.8	-0.8	-2.3	-1.7	-1.6	-2.1	-1.6	-1.1	-1.7	1.3	1.2	-1.5	2.0
Pulse wave reflection index	0.3	0.4	1.9	0.2	-0.1	-0.6	-1.4	-0.4	-0.4	-1.3	-0.4	0.1	0.1	-0.1	0.1	-0.6	0.0	0.6	0.0	0.4	1.1
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.7	-0.5	-0.5	-1.0	-1.9	-0.2	-0.9	-1.0	-1.1	-0.9	-0.8	-1.3	-0.8	-1.4	-1.0	1.5	1.4	-0.7	1.2
Loud music exposure frequency	1.1	1.2	2.3	1.5	1.1	1.0	0.9	1.5	0.9	-0.8	0.6	1.3	1.3	1.4	1.4	1.2	0.5	0.6	-0.1	1.4	-0.9
Qualifications: O levels/GCSEs or equivalent	3.2	5.0	10.2	-2.0	-1.1	-1.8	-2.3	-1.4	-3.1	0.4	-1.6	-2.5	-2.4	-2.7	-2.4	-1.9	-1.8	2.9	3.2	-2.4	2.6
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	4.0	-0.6	-0.7	0.1	-0.4	-0.8	0.1	-2.0	-0.9	-0.5	-0.5	-0.8	-0.5	0.1	0.2	-1.1	-0.7	-0.6	-0.3
Blood clot in the leg (DVT)	0.7	0.9	3.3	-1.1	-0.8	-0.4	-1.0	-1.8	-0.8	-1.3	-0.6	-0.8	-0.9	-0.4	-1.0	-0.1	-0.4	-1.0	-1.4	-0.7	0.2
Medication: Paracetamol	3.6	6.0	25.9	1.9	-0.6	0.2	3.4	2.1	5.1	1.4	0.7	2.3	2.2	2.5	2.3	1.3	2.7	-2.9	-2.5	2.3	-3.1
Headache pain in last month	3.0	5.1	15.9	2.2	0.1	0.2	3.6	2.6	4.0	1.4	1.0	2.3	2.2	2.2	2.3	1.1	2.2	-1.4	-0.7	1.7	-3.9
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	5.8	-1.4	-2.4	-1.4	-1.2	-1.1	0.9	-1.2	-2.4	-1.2	-1.3	-1.6	-1.3	-0.8	-1.4	-1.9	-0.7	-1.4	-0.0
Glaucoma (self-reported)	0.5	0.6	2.1	0.5	0.2	-0.2	-0.4	1.4	1.1	0.9	1.1	0.4	0.5	0.3	0.4	-0.7	-0.0	0.9	1.4	0.2	0.3
Gout (self-reported)	0.5	0.6	3.2	0.4	0.6	0.5	0.8	1.1	-0.2	0.9	1.4	0.3	0.3	0.6	0.3	-0.2	0.3	1.8	1.5	0.1	-0.1
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	8.4	1.5	2.7	1.8	0.5	1.2	-0.3	2.9	2.9	1.6	1.6	1.7	1.6	1.6	1.0	0.7	-0.2	1.5	-1.2
Medication: Amlodipine	0.6	0.9	2.9	0.6	1.2	1.7	1.1	0.2	-0.8	0.2	1.6	0.8	0.7	1.0	0.7	1.0	1.2	0.7	0.1	0.6	-0.5
Medication: Ventolin 100micrograms inhaler	0.4	0.6	3.5	0.4	-0.5	0.0	0.5	1.0	1.9	-0.0	-0.5	0.4	0.4	0.1	0.4	0.1	1.0	-1.0	-0.1	0.0	-1.6
Birth weight	1.3	2.8	5.7	-2.1	-1.1	-1.2	-1.7	-1.9	-2.1	-0.3	-0.7	-2.2	-2.1	-2.4	-2.2	-1.3	-0.9	0.8	1.3	-2.1	1.8
Chronic bronchitis/emphysema (mother)	1.5	1.8	5.9	1.0	0.2	1.5	2.1	0.8	1.7	0.7	1.0	1.3	1.1	1.3	1.2	1.1	1.1	-1.4	-1.3	0.9	-2.4
High blood pressure (siblings)	0.4	0.6	3.3	0.4	-0.7	-0.9	-0.0	1.4	1.8	0.2	1.1	0.3	0.4	0.3	0.4	-1.2	-1.1	0.2	0.6	0.3	-0.1
Forced vital capacity (FVC), Best measure	2.7	9.7	17.1	-3.7	-2.9	-2.3	-3.6	-3.9	-2.8	-2.3	-4.0	-3.8	-3.8	-4.1	-3.8	-1.9	-3.0	-1.2	-0.4	-3.6	1.8
Body fat percentage	0.8	3.1	19.4	1.3	1.1	-0.4	-0.0	2.5	-0.6	1.2	0.8	0.7	0.8	0.9	0.7	-2.2	-1.0	4.4	3.6	0.6	1.7
Leg fat percentage (right)	1.1	4.0	25.3	0.9	0.6	-0.7	-0.5	2.1	-0.9	0.4	0.5	0.3	0.4	0.7	0.3	-2.8	-1.8	5.0	4.3	0.3	3.0
Arm fat-free mass (right)	1.4	7.0	15.4	-2.3	-1.6	-1.4	-2.7	-1.4	-3.3	-1.3	-1.6	-2.2	-2.3	-2.4	-2.4	-3.6	-3.1	3.4	3.9	-2.6	3.8
Exposure to tobacco smoke outside home	0.7	0.9	1.8	1.1	0.7	0.5	0.9	0.8	1.2	-1.2	0.6	1.2	1.2	1.3	1.2	0.4	1.3	-0.5	-0.8	1.2	-0.5
Comparative body size at age 10	1.3	3.7	21.5	-0.4	-0.0	-2.0	-0.0	0.7	-1.9	0.0	0.1	-1.0	-0.9	-1.0	-0.9	-2.5	-0.8	4.4	4.6	-1.3	2.2
Number of full brothers	1.7	2.1	5.2	-1.1	-1.7	-1.5	-1.6	-0.7	0.0	-2.2	-1.6	-1.3	-1.2	-1.3	-1.2	-2.3	-2.0	0.9	1.3	-1.4	1.1
Worry too long after embarrassment	0.8	1.3	8.6	1.0	-0.5	-0.4	1.1	2.0	2.9	0.6	-0.8	1.0	1.1	0.8	1.2	0.2	0.7	-0.5	-0.1	1.1	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	3.4	0.1	-0.4	-0.7	-0.1	0.1	-0.2	-0.5	-0.6	-0.2	-0.2	-0.7	-0.2	-1.0	-0.0	1.7	1.9	-0.4	0.6
Wheeze or whistling in the chest in last year	2.4	4.4	11.6	2.0	1.2	2.1	2.6	2.5	3.0	0.8	2.5	2.2	2.0	2.5	2.1	1.0	2.2	-0.9	-0.6	1.5	-3.4
Number of children fathered	0.7	0.8	2.0	1.3	1.2	-0.6	0.2	1.1	0.6	1.4	0.4	1.1	1.2	1.1	1.1	-0.3	-0.4	0.6	-0.2	1.2	0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	5.2	-0.1	1.8	1.7	-0.2	-0.9	-2.3	1.6	1.8	0.3	0.2	0.9	0.1	0.9	-0.1	1.7	0.4	0.4	1.3
Age at first live birth	0.5	1.0	4.6	-0.8	-1.0	-0.1	-0.8	-1.4	-0.5	-0.9	-2.1	-0.8	-0.8	-0.7	-0.7	0.9	-0.2	-1.5	-1.2	-0.4	0.5
Pulse wave peak to peak time	0.4	0.5	1.1	-1.0	-0.7	-0.1	0.5	-0.8	-0.5	0.4	-1.1	-1.0	-1.0	-0.7	-0.9	0.6	-0.3	-0.3	-0.3	-0.9	0.0
Health satisfaction	1.4	1.8	5.2	1.5	1.0	0.8	1.8	2.3	1.4	0.5	2.1	1.1	1.2	1.3	1.2	0.3	1.7	1.2	1.1	1.0	-1.4
Shortness of breath walking on level ground	1.1	1.3	2.3	1.5	1.3	0.3	1.1	0.9	0.9	0.5	1.4	1.5	1.5	1.2	1.5	0.8	1.0	-0.2	-0.8	1.5	-1.2
Qualifications: College or University degree	1.6	5.1	19.2	-2.5	-0.9	-0.8	-2.1	-4.1	-4.4	-0.8	-2.5	-2.4	-2.4	-2.8	-2.5	0.2	-1.1	0.2	0.1	-2.0	2.5
Eye problems/disorders: None of the above	0.6	0.7	4.3	0.3	0.4	-0.9	-0.6	1.4	-0.2	-0.0	-0.1	-0.2	-0.1	-0.4	-0.1	-1.1	-0.3	2.1	1.7	-0.4	-0.6
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.3	0.8	0.9	0.8	-0.2	0.2	-0.1	-0.0	1.2	0.9	0.9	1.1	0.9	-0.1	-0.3	0.6	-0.1	0.9	0.4
Emphysema/chronic bronchitis	2.0	2.3	8.7	0.9	0.1	0.1	2.3	2.6	3.0	-1.1	1.8	1.1	1.0	1.0	1.1	0.2	1.2	-1.0	-0.3	0.8	-2.6
Medication for pain relief, constipation, heartburn	3.2	5.5	28.8	-2.2	0.7	0.5	-2.7	-2.4	-5.4	-0.6	-0.4	-2.1	-2.1	-2.1	-2.2	-0.3	-3.0	2.6	2.3	-2.4	2.6
Neck or shoulder pain in last month	1.5	2.1	5.6	-0.5	-1.8	-2.4	-2.0	0.7	2.2	-1.7	-2.3	-0.7	-0.6	-1.1	-0.6	-1.9	-1.3	-1.2	-0.6	-0.1	1.1
Medication: Blood pressure	0.7	1.2	7.5	0.8	2.1	0.8	0.4	1.1	-0.7	1.2	2.7	0.8	0.9	1.1	0.9	0.2	0.6	1.0	0.2	0.9	-0.2
Angina (self-reported)	0.2	0.3	1.0	0.9	0.1	0.1	0.0	0.5	1.0	0.1	-0.3	0.8	0.8	0.7	0.8	-0.5	0.4	-0.2	-0.2	0.6	-0.4
Migraine (self-reported)	5.6	7.0	12.0	3.1	2.0	1.8	2.6	2.5	3.2	1.0	1.7	3.4	3.3	3.5	3.4	2.6	2.4	-1.5	-2.0	3.4	-2.4
Medication: Ibuprofen	2.4	2.9	8.3	1.5	0.4	0.3	1.8	1.4	2.9	0.5	0.6	1.6	1.5	1.1	1.7	1.1	2.0	-2.5	-2.4	1.8	-2.3
Medication: Allopurinol	0.9	1.2	3.6	1.0	1.4	0.6	1.3	1.9	0.3	1.0	1.5	0.8	0.9	1.1	0.9	0.5	1.1	1.6	1.1	0.7	-0.8
Medication: Omeprazole	0.7	0.8	2.6	0.5	-0.6	-1.5	-0.3	1.4	1.6	0.8	-1.4	-0.1	0.1	-0.9	0.2	-1.4	0.0	0.9	1.1	-0.0	-0.0
Medication: Seretide 50 evohaler	1.1	1.3	3.0	-1.7	-1.7	-0.7	0.2	-0.7	0.6	0.0	-1.3	-1.5	-1.5	-1.5	-1.5	-0.1	0.3	-1.6	-0.6	-1.6	-0.7
Mean time to correctly identify matches	1.5	2.8	8.4	1.0	2.9	2.4	1.8	1.3	-1.0	1.3	1.7	1.1	1.1	1.5	1.1	2.8	2.5	1.5	-0.3	1.3	-0.5
Heart disease (mother)	1.7	2.0	4.8	-1.2	-1.9	-1.6	-1.9	-0.9	0.1	-1.8	-1.0	-1.4	-1.3	-1.5	-1.3	-2.2	-2.1	-0.9	0.3	-1.5	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	4.2	0.8	0.5	-0.8	0.3	1.5	0.1	-1.4	-0.2	0.4	0.5	0.3	0.5	-1.2	-0.5	2.1	1.5	0.5	0.9
Whole body fat mass	0.9	3.8	21.5	0.1	0.2	-1.0	-1.0	1.7	-1.5	0.5	0.0	-0.4	-0.3	-0.2	-0.4	-3.0	-1.9	4.6	4.2	-0.5	2.6
Leg fat mass (right)	1.2	4.7	26.1	-0.1	0.2	-1.1	-1.4	1.4	-1.9	0.3	0.0	-0.5	-0.5	-0.3	-0.6	-3.3	-2.3	5.1	4.6	-0.6	3.4
Arm predicted mass (right)	1.5	7.5	16.7	-2.4	-1.6	-1.4	-2.8	-1.6	-3.5	-0.9	-1.7	-2.4	-2.4	-2.5	-2.6	-3.6	-3.1	3.5	4.1	-2.8	3.8
Pulse rate, automated reading	2.2	7.2	24.1	3.9	0.7	0.2	2.3	4.9	4.6	1.5	1.1	3.1	3.3	2.6	3.3	-1.6	0.8	1.8	2.1	2.5	-2.3
Alcohol intake frequency.	1.0	2.2	8.4	-0.3	1.2	2.5	1.0	-2.2	-2.0	0.4	2.9	0.5	0.2	1.4	0.1	2.4	1.4	-1.2	-1.6	0.3	-0.3
Comparative height size at age 10	0.4	2.0	4.7	-2.2	-1.1	0.6	-1.3	-2.1	-1.6	-1.6	-1.1	-1.4	-1.7	-1.0	-1.6	0.5	-0.9	-1.8	-1.1	-1.6	0.2
Number of full sisters	0.4	0.5	1.3	-1.1	-0.4	0.5	-0.7	-1.0	-0.9	0.7	0.5	-0.8	-0.9	-0.8	-0.9	0.0	-0.4	0.2	0.2	-1.2	-0.1
Suffer from ‘nerves’	0.8	1.3	10.8	0.9	-0.5	-0.5	0.8	2.5	3.3	0.5	-0.2	0.4	0.6	0.2	0.7	0.1	0.5	-0.7	0.3	0.4	-1.6
Overall health rating	2.2	4.6	12.9	2.4	1.1	1.8	1.6	3.0	3.6	1.2	2.8	2.4	2.4	2.4	2.4	0.5	1.7	-0.7	-0.8	2.1	-2.7
Chest pain or discomfort	0.9	1.3	4.8	-1.0	-1.9	-0.9	-1.0	-0.1	1.1	-2.2	-0.7	-1.0	-1.0	-0.9	-1.0	-1.6	-1.0	-0.8	0.6	-1.5	-0.5
Had major operations	1.6	1.9	5.8	-1.4	-0.7	0.2	-1.9	-1.9	-2.2	-1.0	-0.8	-1.1	-1.2	-0.8	-1.3	-0.6	-1.5	1.3	0.9	-1.0	2.4
Age at last live birth	0.4	0.6	3.2	-0.2	0.7	0.7	0.2	-1.1	-1.7	0.3	-0.4	-0.3	-0.3	-0.1	-0.2	1.8	0.8	0.1	-0.7	0.1	0.1
Family relationship satisfaction	1.5	1.8	7.3	0.8	1.1	2.7	1.5	0.3	-0.1	0.8	1.4	1.0	0.9	1.4	0.9	2.5	1.5	-0.3	-0.6	0.6	-2.2
Leg pain on walking	2.0	2.5	8.3	-1.0	-2.4	-2.9	-1.4	0.1	1.4	-1.6	-2.3	-1.5	-1.4	-1.8	-1.3	-1.9	-1.6	-1.2	0.5	-1.4	0.3
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	4.5	-1.2	-2.1	-1.4	-1.1	-0.7	0.7	-0.3	-1.3	-1.2	-1.2	-1.0	-1.1	-1.3	-1.0	-0.9	0.0	-1.2	0.9
Commuting to job workplace: Car/motor vehicle	2.2	2.5	6.5	2.0	1.1	1.0	1.7	2.5	2.4	0.8	1.1	1.7	1.8	1.6	1.8	0.9	1.0	-0.6	-0.5	1.3	-2.5
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	3.3	0.5	1.3	0.8	0.3	-1.1	-1.8	0.5	0.5	0.3	0.3	0.0	0.2	1.2	0.5	1.1	0.4	0.4	0.8
Medication: Aspirin	1.4	1.8	4.9	1.5	-0.1	1.1	1.3	0.8	2.2	-0.5	1.3	1.5	1.5	2.0	1.5	0.3	1.7	-1.0	-1.1	1.5	-1.3
Supplements: Vitamin C	1.8	2.1	4.0	1.5	1.0	1.5	1.6	0.8	1.5	0.5	0.6	1.7	1.7	1.9	1.7	2.0	1.1	-0.9	-1.4	1.5	-1.8
Knee pain experienced in last month	1.5	2.4	17.6	0.4	-1.9	-2.2	-0.4	2.8	4.2	-0.6	-1.2	0.0	0.2	-0.5	0.3	-1.9	-0.7	-1.3	0.1	-0.0	-1.1
Hypertension (Self-reported)	0.2	0.5	4.8	0.3	0.9	0.9	-0.3	0.3	-0.0	-0.1	2.2	0.5	0.5	0.8	0.5	-0.4	-0.5	0.4	-0.1	0.4	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.3	3.9	13.8	-0.9	-2.2	-3.2	-1.5	1.3	1.5	-0.7	-2.3	-1.6	-1.3	-2.0	-1.3	-3.7	-1.6	1.5	2.9	-1.9	1.0
Illnesses of father: Heart disease	1.1	1.5	3.0	-1.2	-1.4	-1.7	-1.1	-0.1	-0.1	-0.6	-1.5	-1.5	-1.5	-1.2	-1.4	-1.7	-1.0	0.5	1.3	-1.6	0.9
Illnesses of siblings: Diabetes	0.3	0.4	1.0	-0.8	-0.6	-0.2	-0.6	-0.3	0.2	-1.0	0.0	-0.6	-0.6	-0.1	-0.6	-0.9	-0.6	0.3	0.6	-0.6	0.9
Smoking status: Previous	0.7	1.1	6.1	1.0	-1.0	0.1	1.0	2.0	2.5	0.3	0.3	0.8	0.8	1.0	0.8	-0.5	-0.5	-0.2	0.5	0.4	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	2.1	-0.7	0.1	-0.0	-0.2	-0.7	-0.7	0.0	-1.4	-0.6	-0.6	-1.0	-0.6	0.8	0.4	-1.0	-0.7	-0.6	0.0
Whole body fat-free mass	1.5	8.8	13.3	-3.1	-2.0	-1.9	-3.3	-1.7	-3.6	-1.8	-2.1	-3.0	-3.1	-3.1	-3.1	-3.6	-3.3	2.8	3.6	-3.3	3.6
Leg fat-free mass (right)	0.9	4.9	9.5	-2.1	-1.3	-1.9	-2.6	-0.5	-2.5	-1.2	-1.6	-2.1	-2.1	-2.5	-2.2	-3.1	-2.4	2.3	2.9	-2.4	2.5
Arm fat percentage (left)	0.8	3.3	19.7	0.5	0.4	-1.2	-0.7	2.2	-0.9	0.6	0.5	-0.2	-0.1	-0.1	-0.1	-2.9	-1.4	4.4	4.1	-0.3	2.0
Average weekly red wine intake	2.1	3.0	7.6	-1.6	-2.5	-2.0	-1.7	-0.9	-0.2	-0.9	-2.8	-1.8	-1.7	-2.0	-1.7	-2.2	-2.1	0.6	1.3	-1.8	1.4
Handedness (chirality/laterality): Left-handed	0.7	0.9	4.3	-0.7	0.4	1.2	0.8	-1.2	-1.4	-0.2	0.4	-0.3	-0.5	0.3	-0.4	2.1	0.7	-1.0	-1.4	-0.4	-1.0
Mood swings	0.7	1.3	6.6	0.8	-0.5	-1.2	-0.4	2.2	2.6	-0.8	-1.2	0.4	0.6	-0.1	0.6	-2.0	-0.4	0.8	0.9	0.8	0.6
Loneliness, isolation	1.5	2.0	7.3	1.5	1.4	0.6	1.1	2.7	1.8	-0.5	2.6	1.3	1.3	1.6	1.4	0.1	0.7	0.3	0.6	1.0	-1.9
Long-standing illness, disability or infirmity	1.3	2.0	6.4	1.7	0.8	0.5	1.4	1.8	2.2	0.4	2.5	1.5	1.6	1.3	1.6	0.1	1.0	0.1	0.1	1.1	-2.1
Ever had bowel cancer screening	0.6	0.7	1.8	-0.9	-1.2	-0.1	-0.8	-0.5	-0.4	-0.3	-0.2	-0.8	-0.9	-0.6	-0.9	-1.4	-1.3	0.7	1.2	-1.1	0.6
Diabetes diagnosed by doctor	0.6	1.0	6.2	-0.2	0.8	0.5	0.3	0.6	-1.2	0.3	2.5	-0.5	-0.4	-0.2	-0.4	-0.7	0.5	1.8	2.0	-0.5	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	2.9	-0.6	0.7	-0.6	-1.1	-0.4	-1.7	-0.9	-0.4	-0.8	-0.7	-1.0	-0.7	0.3	-0.1	0.4	0.2	-0.4	0.8
Friendships satisfaction	0.8	1.0	4.9	-0.6	0.3	2.1	1.6	-0.8	-0.8	-0.3	0.7	-0.2	-0.3	0.3	-0.3	2.2	0.9	-0.6	-0.6	-0.5	-1.1
Qualifications: nursing, teaching	1.1	1.8	6.7	-0.9	-0.7	-0.9	-0.5	-0.8	-1.9	-0.1	-0.8	-1.5	-1.4	-1.5	-1.4	-0.6	-0.6	2.0	2.6	-1.5	1.5
Commuting to job workplace: Walk	0.4	0.4	1.7	0.3	0.8	-0.7	-0.3	-0.5	-0.6	1.2	-0.3	0.2	0.2	-0.4	0.2	0.1	1.2	0.2	-0.3	0.8	1.3
Eye problems/disorders: Cataract	0.8	0.9	3.2	0.7	0.2	0.8	0.4	-0.5	0.7	0.5	-0.2	1.1	1.1	0.5	1.1	1.1	0.9	-1.6	-1.8	1.5	0.3
Mouth/teeth dental problems: Mouth ulcers	2.7	4.3	8.1	-2.9	-2.6	-0.9	-1.4	-2.8	-1.2	-2.5	-2.3	-2.6	-2.8	-2.1	-2.8	-0.6	-1.5	-0.9	-0.1	-2.5	1.4
Medication for cholesterol	0.8	1.2	5.8	1.2	1.8	0.0	1.4	0.6	-0.7	0.9	0.2	1.0	1.0	0.7	1.1	1.6	2.4	0.0	-0.4	1.3	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.8	0.3	-0.7	-0.1	0.7	0.0	1.4	-0.4	-0.3	0.7	0.6	0.5	0.5	-0.4	0.3	-1.7	-1.5	0.4	-0.8
Back pain experienced in last month	0.7	1.1	6.5	0.9	-0.1	-0.9	1.3	2.5	2.0	0.7	-0.2	0.2	0.3	0.4	0.5	-0.2	0.9	0.7	0.8	0.4	-1.4
Mineral and other dietary supplements	0.9	1.2	3.5	-0.2	-0.4	-1.0	-1.6	-0.4	-1.0	0.0	-0.5	-0.6	-0.5	-0.6	-0.6	-1.7	-1.7	1.9	1.4	-0.3	1.9
Breast cancer (self-reported)	0.9	1.1	4.4	-1.0	-2.1	-1.5	-0.3	0.0	1.4	-1.1	-1.6	-1.0	-1.0	-1.1	-0.9	-0.4	0.1	-1.4	-0.5	-0.8	-0.2
Asthma (self-reported)	1.3	2.5	10.4	0.9	0.1	0.6	2.0	1.6	3.0	0.4	0.6	1.2	1.1	1.0	1.1	1.1	2.1	-2.1	-1.3	0.7	-3.2
Osteoporosis (self-reported)	0.3	0.3	1.4	0.3	0.3	-0.0	0.7	0.9	0.7	0.6	0.1	0.1	0.2	-0.2	0.3	0.8	1.2	0.2	0.4	0.1	-1.1
Osteoarthritis (self-reported)	1.7	2.2	13.3	-0.7	-2.4	-1.7	-0.2	0.3	2.1	-3.6	-1.4	-0.9	-0.9	-1.0	-0.8	-2.3	-0.7	-1.2	-0.5	-0.7	-0.1
Medication: Aspirin	2.1	2.8	6.6	2.1	0.2	1.5	1.7	1.1	2.5	-0.1	1.4	2.1	2.1	2.6	2.0	0.6	1.8	-0.8	-1.1	2.0	-1.4
Medication: Gliclazide	2.5	2.9	4.6	-2.0	-1.5	-1.5	-1.1	-1.1	-1.7	-1.1	-0.6	-2.1	-2.1	-1.9	-2.1	-2.0	-1.2	1.0	1.9	-2.1	1.9
Illnesses of father: None of the above (group 1)	1.0	1.2	3.1	0.6	1.7	1.5	0.4	-0.6	-1.8	1.0	1.4	1.1	1.0	1.0	0.9	1.7	0.2	0.4	-0.5	1.2	0.5
Smoking status: Current	0.4	0.7	2.8	0.8	0.3	0.1	0.4	1.7	0.8	0.0	0.5	0.6	0.5	0.1	0.5	-1.3	0.4	1.4	1.5	0.1	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.9	6.0	10.9	-2.5	-2.0	-2.8	-3.2	-2.4	-2.1	-1.6	-3.3	-2.8	-2.7	-2.8	-2.7	-2.3	-2.7	0.5	0.6	-2.5	2.9
Whole body water mass	1.6	9.3	13.8	-3.1	-2.1	-2.0	-3.4	-1.8	-3.6	-1.9	-2.2	-3.1	-3.2	-3.2	-3.2	-3.7	-3.4	2.8	3.6	-3.4	3.7
Leg predicted mass (right)	0.9	4.7	9.2	-2.0	-1.2	-1.9	-2.6	-0.5	-2.5	-1.2	-1.5	-2.1	-2.1	-2.5	-2.1	-3.0	-2.3	2.3	2.8	-2.4	2.4
Arm fat mass (left)	1.1	4.7	22.0	-0.5	-0.3	-1.5	-1.5	1.3	-1.8	-0.0	0.0	-0.9	-0.9	-0.9	-0.9	-3.7	-2.3	4.7	4.6	-1.1	2.9
Number of self-reported non-cancer illnesses	0.7	1.1	4.8	1.0	0.3	0.2	0.9	2.2	2.1	-0.3	1.2	0.8	0.9	0.7	0.9	-0.7	1.1	0.9	1.0	0.5	-1.1
Average weekly champagne plus white wine intake	2.0	2.8	9.2	-2.0	-0.7	-0.9	-1.6	-2.4	-3.0	0.0	-2.3	-1.7	-1.6	-2.1	-1.7	-0.1	-1.5	0.7	0.6	-1.7	1.7
Miserableness	1.7	3.0	13.6	1.7	0.2	-0.0	1.6	3.7	3.6	0.4	1.8	1.5	1.6	1.6	1.6	-1.4	0.8	0.6	1.1	1.2	-1.7
Guilty feelings	0.4	0.6	2.9	-0.0	-0.4	-0.5	0.4	1.2	1.6	-0.8	-0.1	0.1	0.1	-0.2	0.2	-0.1	0.4	-1.2	-0.3	-0.2	-1.7
Wears glasses or contact lenses	0.2	0.3	1.9	0.1	-0.8	-0.9	-0.1	0.4	1.4	0.2	-0.3	-0.0	-0.0	0.2	0.0	-0.7	-0.3	-0.4	0.1	0.1	0.0
Ever taken oral contraceptive pill	0.4	0.5	1.0	0.5	0.6	0.9	0.7	-1.0	-0.8	0.7	-0.6	0.6	0.6	0.3	0.6	0.7	0.4	0.2	-1.0	1.0	0.4
Hearing aid user	0.7	0.8	1.9	1.0	1.1	0.5	1.1	0.7	0.2	0.4	0.5	1.1	1.1	1.1	1.1	1.2	0.8	-0.1	-1.2	1.4	-0.6
Mother’s age at death	0.3	0.4	1.2	-0.1	0.7	1.0	-0.5	-0.9	-1.1	0.4	0.7	0.2	0.1	0.6	0.1	0.7	0.3	0.4	-0.3	0.4	1.1
Financial situation satisfaction	1.2	1.5	5.9	1.1	1.0	1.1	1.4	1.9	1.4	-0.7	0.5	0.9	1.0	0.6	1.1	1.5	1.2	-0.8	-0.6	0.7	-2.4
Tinnitus: Yes, now most or all of the time	2.0	2.3	6.7	1.7	1.8	0.7	1.6	1.5	0.9	1.5	1.4	1.8	1.8	1.3	1.8	1.0	1.1	-0.7	-1.4	1.4	-2.6
Commuting to job workplace: Public transport	0.3	0.4	1.6	-0.0	0.1	-0.4	-0.6	-0.6	-0.9	1.3	-0.3	-0.1	-0.0	0.1	-0.1	-0.1	-0.3	1.1	0.8	0.1	1.0
Eye problems/disorders: Glaucoma	0.5	0.6	2.5	0.8	1.0	0.3	-0.0	1.1	0.8	1.6	1.0	0.8	0.9	0.8	0.8	0.3	-0.1	0.9	0.6	0.7	-0.0
Medication: Blood pressure	0.4	0.8	3.8	-0.9	-1.7	0.2	-1.1	-1.1	0.5	-0.0	-0.3	-0.6	-0.6	-0.1	-0.8	-1.2	-2.0	-0.2	0.1	-0.9	1.0
Pain type(s) experienced in last month: Hip pain	0.8	1.1	4.9	-0.5	-1.5	-1.7	-0.8	1.2	1.3	-0.6	-0.3	-0.7	-0.6	-0.8	-0.6	-2.2	-0.5	0.3	1.3	-0.9	0.0
Supplements: Fish oil (including cod liver oil)	1.0	1.3	4.5	0.5	0.3	1.3	1.3	0.0	1.1	-0.0	0.2	0.9	0.8	1.1	0.8	1.8	1.2	-2.1	-1.8	0.7	-1.6
High cholesterol (Self-reported)	0.4	0.7	4.2	0.2	0.4	0.7	0.9	-0.1	-0.9	0.1	1.3	0.1	0.1	0.4	0.0	-0.1	0.8	2.0	1.7	-0.0	0.6
Medication: Bendroflumethiazide	0.5	0.8	2.6	0.9	0.4	-0.4	-0.1	1.6	1.6	1.2	0.8	1.1	1.1	0.5	1.1	-0.6	-0.5	-0.1	-0.5	1.0	-0.7
Medication: Paracetamol	4.7	7.2	28.3	2.1	-0.3	0.5	3.6	2.2	5.3	1.2	0.6	2.7	2.5	2.8	2.6	1.7	2.5	-3.4	-3.3	2.6	-3.3
Medication: Lisinopril	0.5	0.6	2.5	-1.0	-0.7	-0.4	-0.7	-1.0	-0.6	-1.6	-0.5	-0.9	-1.0	-0.8	-1.0	-0.1	-0.5	-0.7	-0.0	-1.0	0.0
Medication: Atorvastatin	0.4	0.5	2.4	0.6	0.3	-0.1	0.2	0.6	0.2	0.5	1.3	0.3	0.4	0.7	0.3	-1.1	-0.2	1.6	1.2	0.2	0.1
Illnesses of father: High blood pressure	0.5	0.7	5.2	0.7	-1.0	-0.6	-0.2	0.9	2.3	-0.7	-1.1	0.4	0.5	0.3	0.5	-1.1	-0.1	0.1	0.2	0.6	0.4
Alcohol drinker status: Never	0.5	0.7	2.5	-0.5	-0.5	-0.5	-1.5	-0.3	-0.2	-0.9	-0.4	-0.6	-0.6	-0.8	-0.6	-1.3	-1.0	0.7	0.5	-0.4	1.6
Ever smoked	0.5	0.9	3.2	0.9	-1.0	0.4	0.5	1.4	1.4	0.9	-0.8	0.7	0.6	0.7	0.6	-1.0	-0.6	1.8	1.6	0.2	-0.6
Basal metabolic rate	1.6	8.6	15.1	-2.8	-1.8	-1.9	-3.2	-1.4	-3.6	-1.6	-1.9	-2.8	-2.9	-3.0	-3.0	-3.7	-3.4	3.2	3.9	-3.1	3.8
Leg fat percentage (left)	1.0	3.7	23.0	1.2	1.0	-0.6	-0.2	2.4	-0.7	0.7	0.7	0.6	0.7	0.9	0.6	-2.6	-1.3	4.8	4.0	0.6	2.5
Arm fat-free mass (left)	1.8	9.2	17.2	-2.9	-2.0	-1.9	-3.3	-1.9	-3.6	-1.8	-1.9	-2.8	-2.9	-2.8	-3.0	-4.1	-3.6	3.2	3.9	-3.1	4.2
Number of operations (self-reported)	1.4	2.0	6.1	-1.1	-1.7	-1.0	-1.8	-0.4	-0.4	-2.2	-0.2	-1.1	-1.1	-1.3	-1.1	-2.5	-1.6	1.1	1.9	-1.3	1.6
Average weekly beer plus cider intake	0.7	1.0	3.7	1.1	0.6	0.2	1.9	1.9	1.6	0.0	0.8	0.9	1.0	1.1	1.0	0.0	1.0	0.7	0.3	0.9	-0.7
Irritability	0.4	0.7	3.9	0.7	-0.3	-0.5	0.5	2.0	1.8	-1.3	-0.3	0.2	0.3	0.3	0.5	-1.1	-0.0	0.3	0.3	0.6	-0.4
Risk taking	1.5	2.2	7.7	-2.1	-1.0	0.4	-0.2	-2.8	-1.9	-1.3	-0.7	-1.6	-1.9	-1.3	-1.9	0.7	-0.3	-1.6	-1.5	-1.6	0.3
Ever had prostate specific antigen (PSA) test	0.2	0.2	1.3	0.4	0.1	-0.1	-0.3	0.1	-0.0	-1.1	-0.7	0.3	0.4	0.2	0.4	0.1	-0.7	0.4	0.4	0.4	0.8
Fractured/broken bones in last 5 years	0.6	0.8	3.9	-1.1	-0.5	-0.1	-0.3	-1.5	-0.2	0.3	-0.6	-0.6	-0.7	-0.6	-0.7	1.0	0.5	-1.9	-2.0	-0.4	0.1
Age started oral contraceptive pill	0.8	0.9	3.3	-1.1	-0.7	-0.7	-1.5	-1.1	-0.9	-1.2	-0.7	-0.9	-0.9	-0.8	-0.9	-1.1	-0.5	0.6	0.2	-0.5	1.8
Diastolic blood pressure, automated reading	1.0	3.1	8.5	2.4	2.0	1.5	1.2	2.1	1.4	0.2	2.9	2.1	2.1	2.2	2.1	0.7	1.4	-0.2	-0.7	2.4	-1.3
Ever depressed for a whole week	0.6	0.7	2.0	0.9	0.5	1.0	1.2	0.8	0.7	0.8	0.6	0.8	0.9	0.9	0.9	1.2	0.8	-0.2	0.1	0.6	-1.4
Unable to work because of sickness or disability	0.2	0.3	1.3	0.0	-0.3	-0.6	0.3	0.7	0.8	-1.0	0.2	0.0	-0.0	-0.3	-0.0	-1.1	0.0	0.8	0.8	-0.3	-0.2
Commuting to job workplace: Cycle	2.6	3.2	8.5	-2.5	-0.9	-0.3	-1.6	-2.8	-2.9	-2.2	-0.8	-2.1	-2.2	-1.6	-2.2	0.2	-1.5	-0.4	0.1	-1.9	1.6
Myopia	0.1	0.1	0.5	0.1	-0.2	-0.1	0.1	0.2	0.1	0.1	0.7	0.0	0.0	0.1	0.0	-0.6	-0.4	0.0	0.4	-0.1	-0.4
Vascular/heart problems diagnosed by doctor	0.2	0.5	3.1	-0.5	-0.9	-0.7	-0.3	-0.3	-0.3	0.1	-1.8	-0.7	-0.6	-1.1	-0.6	0.0	-0.1	0.1	0.7	-0.7	0.1
Cholesterol lowering medication	0.6	0.9	4.5	-0.6	-1.5	-0.1	-0.8	-0.5	0.8	-1.7	0.1	-0.5	-0.5	-0.3	-0.6	-2.1	-1.3	0.5	1.0	-0.8	1.0
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	3.6	0.4	-0.9	-1.6	-0.5	1.0	1.6	0.1	-1.9	-0.2	-0.0	-1.0	0.0	-1.5	-0.3	0.7	1.0	-0.2	0.0
Pain experienced in last month	1.8	3.0	19.4	-1.5	0.7	0.6	-1.8	-3.6	-4.4	-0.7	-0.1	-1.2	-1.2	-1.0	-1.4	0.4	-0.7	0.9	-0.3	-1.1	2.5
Supplements: Calcium	1.6	1.7	4.8	0.9	1.2	1.7	1.1	0.4	0.7	0.9	1.1	1.1	1.1	1.0	1.1	2.2	1.2	-1.7	-1.7	1.0	-2.1
Basal cell carcinoma (self-reported)	0.6	0.7	2.6	-0.5	-1.1	-1.3	-0.2	1.1	0.7	-0.7	-1.6	-0.6	-0.5	-1.1	-0.5	-0.9	-0.3	0.5	1.1	-0.4	0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.4	-0.2	-0.2	-1.0	-0.5	0.4	-0.3	-0.8	-0.3	-0.3	-0.2	-0.5	-0.2	-1.0	-0.4	0.8	1.2	-0.5	0.3
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	4.2	-1.4	-1.1	-0.5	-1.3	-2.1	-0.9	-1.5	-0.9	-1.0	-1.1	-0.7	-1.2	-0.5	-0.8	-1.0	-1.4	-0.9	0.5
Heart disease (siblings)	1.2	1.5	3.2	-1.1	-1.8	-1.8	-1.5	-0.8	0.4	-1.4	-0.7	-1.1	-1.1	-0.7	-1.1	-1.8	-1.8	-0.8	0.1	-0.8	1.4
Alcohol drinker status: Previous	0.7	0.8	2.5	0.6	1.1	1.5	0.7	0.2	-0.4	1.1	1.6	0.9	0.8	1.3	0.8	1.0	0.7	0.4	0.2	0.5	-0.8
Pack years of smoking	2.0	2.9	9.0	2.0	1.5	0.3	1.5	3.0	2.7	1.5	1.8	1.8	1.9	1.6	1.9	0.4	1.0	0.2	-0.2	1.6	-2.3
Impedance of whole body	2.0	10.1	31.4	1.9	1.8	2.9	3.1	0.1	2.6	2.1	0.6	2.3	2.2	2.5	2.3	5.4	3.8	-5.0	-5.6	2.7	-4.2
Leg fat mass (left)	1.1	4.4	25.0	0.1	0.3	-1.1	-1.3	1.5	-1.8	0.4	0.0	-0.4	-0.3	-0.3	-0.4	-3.3	-2.1	5.0	4.5	-0.5	3.2
Arm predicted mass (left)	1.8	9.4	18.1	-3.0	-1.9	-1.9	-3.3	-1.9	-3.8	-1.8	-1.9	-2.9	-3.0	-2.9	-3.1	-4.0	-3.5	3.3	3.9	-3.2	4.2