TWAS hub - ZBTB37

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0083	0.0046	3.1e-03	0.002	0.006	0.001	0.005	0.000	0.0850	0.00460	0.1900	0.0087	0.330
2	TCGA	Breast Invasive Carcinoma	0.0224	0.0135	8.7e-04	0.000	0.007	0.008	NA	0.002	0.3800	0.00930	0.0074	NA	0.100
3	TCGA	Lung Adenocarcinoma	0.0664	0.0368	4.9e-05	0.003	0.029	0.004	NA	0.008	0.1300	0.00022	0.0910	NA	0.040
4	TCGA	Lung Squamous Cell Carcinoma	0.0273	0.0182	4.4e-03	0.008	0.006	0.012	NA	0.003	0.0400	0.05400	0.0140	NA	0.120
5	TCGA	Prostate Adenocarcinoma	0.0403	0.0256	3.2e-03	0.016	0.016	0.003	NA	0.012	0.0081	0.00780	0.1300	NA	0.019

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Alcohol usually taken with meals	11.4	18.5	40.8	6.4	2.2	1.2	5.0	4.5
Migraine (self-reported)	8.1	10.0	11.9	-3.0	-3.2	-2.7	-3.5	-3.5
Schizophrenia vs Biploar Disorder	7.9	10.4	19.0	-4.4	-1.8	-1.2	-4.2	-3.3
Medication: Paracetamol	7.8	12.1	22.5	-4.7	-3.2	-3.0	-3.1	-3.0
Medication: Paracetamol	6.1	10.1	22.3	-4.7	-2.5	-2.2	-3.1	-2.8
Tense / ‘highly strung’	5.9	9.7	20.3	-4.5	-1.9	-1.8	-3.3	-3.2
Medication for pain relief, constipation, heartburn	5.4	9.2	19.1	4.4	2.3	2.2	2.9	3.0
Respiratory disease	4.8	10.7	20.1	-4.5	-2.8	-1.8	-3.9	-2.8
Pain experienced in last month	4.6	7.7	19.9	4.5	0.5	0.2	3.0	3.1
Headache pain in last month	4.5	7.8	22.9	-4.8	-0.9	-0.1	-3.3	-2.1
Number of treatments/medications taken	4.2	7.5	22.3	-4.7	-1.5	-0.9	-2.4	-2.5
Qualifications: O levels/GCSEs or equivalent	4.2	6.7	7.6	2.7	2.6	2.8	2.5	2.3
Medication: Ibuprofen	4.2	5.0	6.9	-2.4	-1.8	-2.1	-2.6	-2.2
Worry (Nagel 2018)	4.1	8.7	20.5	-4.5	-1.4	-1.1	-3.2	-3.1
Neuroticism	4.1	9.9	19.4	-4.4	-1.6	-1.3	-3.2	-4.0
Emphysema/chronic bronchitis	4.0	4.5	11.6	-3.4	-0.9	-0.2	-2.4	-2.1
Frequency of tiredness / lethargy in last 2 weeks	3.9	6.3	13.6	-3.7	-1.3	-0.6	-2.7	-3.0
Impedance of arm (left)	3.9	18.0	26.3	-2.9	-4.9	-5.1	-4.7	-3.1
Neuroticism score	3.8	8.0	15.9	-4.0	-1.6	-1.3	-2.9	-3.4
Impedance of arm (right)	3.7	17.5	29.5	-2.5	-5.0	-5.4	-4.3	-2.9
Blood Red Count	3.5	33.7	54.0	-5.2	-5.0	-4.8	-6.2	-7.3
Number of incorrect matches in round	3.3	5.5	7.8	-2.4	-2.8	-2.4	-2.5	-1.4
Impedance of whole body	3.3	16.8	28.2	-2.6	-4.8	-5.3	-4.3	-2.8
Reaction Time	3.2	6.1	12.0	1.2	-3.5	-3.1	-1.5	-2.3
Wheeze or whistling in the chest in last year	3.0	5.4	16.7	-4.1	-0.8	-0.4	-2.5	-1.8
Average weekly champagne plus white wine intake	3.0	4.1	10.0	3.2	1.1	0.9	1.9	2.2
Arm fat-free mass (left)	3.0	15.3	20.2	3.5	4.2	3.8	4.5	3.4
Arm predicted mass (left)	3.0	15.4	20.7	3.6	4.2	3.8	4.5	3.4
Lung FVC	2.9	14.6	21.4	3.1	3.7	2.9	4.6	4.5
Taking other prescription medications	2.9	4.4	13.5	-3.7	-0.3	0.7	-2.0	-2.0
Nervous feelings	2.9	5.5	8.5	-2.4	-1.8	-1.6	-2.6	-2.9
Commuting to job workplace: Car/motor vehicle	2.9	3.3	9.4	-3.1	-0.9	-0.7	-1.7	-1.6
Hypothyroidism (self reported)	2.8	6.4	8.9	-1.5	-2.9	-2.5	-3.0	-2.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.8	8.9	12.6	3.4	2.6	1.4	3.5	3.6
Suffer from ‘nerves’	2.8	4.5	9.4	-3.1	-0.6	-0.4	-2.5	-2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.8	5.9	11.7	3.0	1.2	0.6	3.4	2.6
Fasting Glucose	2.7	3.3	6.3	0.6	-2.2	-2.5	-1.1	-2.0
Rheumatoid Arthritis	2.7	3.7	4.8	-1.4	-2.2	-2.1	-1.9	-2.0
Arm predicted mass (right)	2.7	13.8	17.4	3.1	4.2	3.9	4.1	3.1
Asthma (self-reported)	2.7	5.3	12.7	-3.6	-1.7	-1.0	-2.6	-1.7
Frequency of tenseness / restlessness in last 2 weeks	2.6	4.0	13.0	-3.6	0.9	1.5	-1.5	-1.4
Qualifications: None of the above	2.6	5.5	9.0	-2.6	-1.9	-1.6	-2.3	-3.0
Asthma	2.6	5.1	14.1	-3.8	-1.5	-0.7	-2.5	-1.6
Overall health rating	2.6	5.6	14.3	-3.8	-1.2	-0.8	-2.4	-2.4
Intelligence (Savage-Jansen 2018)	2.5	7.8	17.9	4.2	1.3	1.7	3.1	2.6
Trunk fat-free mass	2.5	14.1	16.6	3.8	3.9	3.4	4.1	3.6
Arm fat-free mass (right)	2.5	12.7	16.1	3.0	4.0	3.7	4.0	2.9
Miserableness	2.5	4.3	14.1	-3.8	0.0	0.8	-1.4	-2.1
Commuting to job workplace: Cycle	2.5	3.0	5.7	2.4	1.0	0.8	1.7	2.2
Stomach or abdominal pain in last month	2.4	3.0	4.9	0.4	2.1	2.2	1.3	2.0
Alcohol intake versus 10 years previously	2.4	3.5	8.0	-0.0	-2.6	-2.8	-1.6	-0.7
Trunk predicted mass	2.4	13.9	16.3	3.8	3.8	3.4	4.0	3.6
Pulse rate, automated reading	2.4	7.8	24.5	-5.0	0.6	1.7	-2.0	-2.6
Knee pain experienced in last month	2.4	3.7	11.0	-3.3	-0.3	-0.1	-1.7	-2.2
Depressed Affect (Nagel 2018)	2.3	4.9	14.1	-3.8	-0.1	0.5	-1.6	-2.7
Neuroticism (Nagel 2018)	2.3	5.3	14.3	-3.8	-0.4	-0.0	-1.9	-2.9
Relative age of first facial hair	2.3	4.7	15.1	3.9	0.8	0.8	2.1	1.6
Past tobacco smoking	2.3	4.2	14.7	3.8	-1.5	-1.9	0.5	0.5
Qualifications: College or University degree	2.3	7.3	20.5	4.5	1.0	0.6	2.3	3.0
Mean time to correctly identify matches	2.3	4.4	10.0	1.1	-3.2	-2.5	-1.0	-1.8
BMI	2.2	12.7	23.3	3.0	3.9	4.8	3.8	1.2
Vitamin and mineral supplements	2.2	3.0	5.0	2.2	1.9	1.5	1.9	0.7
Forced vital capacity (FVC), Best measure	2.2	8.2	15.1	2.9	2.3	1.1	3.2	3.9
Had major operations	2.2	2.6	4.5	2.1	1.0	0.9	2.0	1.7
Supplements: Vitamin C	2.2	2.6	6.0	-2.4	-1.7	-1.1	-1.4	-1.0
Medication: Gliclazide	2.2	2.5	3.5	1.5	1.7	1.9	1.5	1.4
Whole body water mass	2.2	12.7	15.8	3.4	3.7	3.5	4.0	3.1
Basal metabolic rate	2.2	12.2	15.4	3.5	3.7	3.5	3.9	2.8
Ovarian Cancer	2.1	2.7	5.5	1.1	2.4	1.9	1.3	1.3
Bipolar Disorder (2011)	2.1	2.1	6.5	2.5	-0.3	-0.9	0.0	1.7
Ulcerative Colitis	2.1	3.0	5.6	-0.9	-1.8	-1.5	-1.8	-2.4
Number of live births	2.1	3.0	3.9	1.4	2.0	1.7	1.6	1.8
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	4.6	-2.1	-1.3	-1.4	-1.8	-1.5
Prospective memory result	2.1	2.5	4.7	-1.3	-2.0	-2.2	-1.5	0.2
Number of full brothers	2.1	2.6	5.5	0.4	2.3	1.6	1.6	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.4	5.9	-0.6	2.3	2.4	0.9	0.2
Whole body fat-free mass	2.1	11.9	14.7	3.4	3.6	3.4	3.8	2.9
Financial situation satisfaction	2.1	2.7	4.9	-1.7	-1.3	-1.0	-2.2	-1.7
Pack years of smoking	2.1	3.1	6.8	-2.6	-0.8	-0.7	-1.9	-2.0
Smoking Status	2.0	4.8	16.4	-4.0	1.3	1.7	-1.2	-1.3
Pack years adult smoking proportion	2.0	3.0	5.9	-2.4	-0.8	-0.8	-1.9	-2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.6	6.7	-2.6	-0.3	0.1	-1.6	-1.9
Body mass index (BMI)	2.0	8.5	16.6	2.0	3.4	4.1	3.1	0.7
Weight	2.0	9.7	13.2	3.2	3.3	3.3	3.6	1.8
Serious illness, injury or assault to yourself	1.9	2.3	6.0	0.5	-2.1	-2.4	-0.3	-1.0
Depression (self-reported)	1.9	2.3	5.9	-0.9	2.1	2.4	-0.4	-0.6
Breastfed as a baby	1.9	2.3	5.1	1.4	1.3	1.2	2.3	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	7.7	-1.8	1.8	2.8	-0.1	0.2
Schizophrenia (2014)	1.8	4.0	6.3	-2.1	-1.7	-1.9	-2.5	-1.6
Impedance of leg (left)	1.8	8.8	17.1	-1.9	-3.4	-4.1	-3.0	-1.6
Hip circumference	1.8	7.7	11.8	3.2	2.6	2.5	3.4	1.8
Forced expiratory volume in 1-second (FEV1)	1.8	5.9	10.9	3.3	1.7	0.7	2.7	2.9
Comparative body size at age 10	1.8	5.1	10.5	1.9	2.9	3.2	1.5	0.8
Worry too long after embarrassment	1.8	3.0	5.0	-2.0	-1.1	-0.9	-2.0	-2.2
Smoking status: Previous	1.8	2.7	10.4	-3.2	0.8	1.0	-0.8	-0.8
Medication: Aspirin	1.8	2.3	7.0	-2.6	-1.1	-0.8	-1.2	-1.1
Supplements: Calcium	1.8	2.0	3.1	-1.2	-1.6	-1.4	-1.8	-1.0
Neuroticism (2016)	1.7	2.5	7.2	-2.7	-0.2	0.3	-1.2	-1.9
Fed-up feelings	1.7	3.0	9.1	-3.0	1.0	1.8	-0.6	-1.2
High blood pressure (mother)	1.7	2.3	3.0	-1.6	-1.4	-1.2	-1.7	-1.6
Forced vital capacity (FVC)	1.7	6.4	11.0	3.1	1.8	0.7	2.7	3.3
Arm fat mass (right)	1.7	7.0	12.2	2.0	3.0	3.5	2.9	0.9
Average weekly red wine intake	1.7	2.5	3.6	0.3	1.8	1.7	1.9	1.7
Ever had bowel cancer screening	1.7	1.9	3.7	-0.7	1.5	1.9	1.3	1.3
Supplements: Fish oil (including cod liver oil)	1.7	2.3	3.3	-1.4	-1.6	-1.8	-1.6	-1.0
Depression (Nagel 2018)	1.6	2.5	9.3	-3.1	0.5	1.0	-0.8	-1.1
Medication: Metformin	1.6	2.2	4.5	1.0	1.8	2.1	0.5	1.3
Financial difficulties in last 2 years	1.6	2.2	4.4	-2.1	-1.2	-0.7	-1.5	-1.6
Happiness	1.6	2.0	3.5	-1.2	-1.2	-1.0	-1.9	-1.6
Hair/balding pattern: Pattern 4	1.6	3.9	10.5	-3.2	-1.1	-0.7	-1.8	-2.0
Birth weight of first child	1.6	2.8	4.9	2.1	1.0	0.7	1.8	2.2
Leg fat mass (right)	1.6	6.3	10.2	2.0	2.8	3.2	3.0	0.6
Loneliness, isolation	1.6	2.3	5.9	-2.4	-0.2	0.2	-1.6	-1.7
Arm fat mass (left)	1.6	6.7	11.9	2.0	3.0	3.5	2.8	0.9
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.6	0.6	1.8	1.9	0.6	1.0
Supplements: Zinc	1.5	1.7	3.3	-0.2	-1.8	-1.6	-1.1	-1.2
Leg fat-free mass (left)	1.5	7.8	9.9	2.8	2.9	3.0	3.1	1.9
Age when periods started (menarche)	1.5	3.6	6.9	2.6	1.2	0.4	2.6	1.7
Qualifications: A levels/AS levels or equivalent	1.5	3.4	8.1	2.8	1.4	1.6	1.6	1.4
Chronic bronchitis/emphysema (mother)	1.5	1.8	5.8	-2.4	-0.8	-0.5	-1.4	-0.5
Long-standing illness, disability or infirmity	1.5	2.3	7.5	-2.7	-0.4	0.3	-1.6	-1.1
Commuting to job workplace: Walk	1.5	1.6	4.3	2.1	-1.1	-1.1	-0.6	-1.0
Mineral and other dietary supplements	1.5	2.0	3.0	1.6	1.3	1.4	1.7	0.9
Ever smoked	1.5	2.6	4.8	-2.2	1.8	1.9	0.9	0.7
Cholesterol lowering medication	1.5	2.2	4.3	-0.5	2.1	1.8	1.3	1.2
Leg predicted mass (left)	1.4	7.4	9.4	2.7	2.8	2.9	3.1	1.9
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	5.6	-2.4	-0.6	-0.3	-1.6	-1.0
Medication for cholesterol	1.4	2.1	3.3	0.6	-1.8	-1.5	-1.5	-1.5
Back pain experienced in last month	1.4	2.1	4.0	-1.9	-0.6	-0.4	-1.5	-2.0
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	4.3	0.9	0.1	-0.4	1.9	2.1
Leg fat mass (left)	1.4	5.6	9.1	2.1	2.6	3.0	2.8	0.5
Hearing difficulty/problems: Yes	1.3	1.9	3.1	-1.7	-1.1	-0.9	-1.8	-1.4
Relative age voice broke	1.3	2.0	4.2	2.1	0.9	1.0	1.9	0.4
Mouth/teeth dental problems	1.3	2.1	6.6	2.6	0.6	0.5	1.2	1.3
Pain all over the body in last month	1.3	1.4	4.5	-2.1	-0.3	-0.0	-1.1	-1.0
Time employed in main current job	1.3	1.4	3.1	-1.4	-0.8	-1.1	-0.7	-1.8
Health satisfaction	1.3	1.7	3.5	-1.9	-0.3	0.3	-1.5	-1.6
Medication: Aspirin	1.3	1.7	5.4	-2.3	-0.9	-0.7	-1.0	-0.9
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	5.0	0.9	0.9	0.8	1.7	2.2
Risk taking	1.3	1.9	5.0	1.3	0.4	-0.3	1.6	2.2
Blood Eosinophil Count	1.2	9.0	12.3	-1.9	-3.4	-2.9	-3.5	-2.9
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.9	-0.3	1.4	0.7	1.5	1.7
Ever had hysterectomy (womb removed)	1.2	1.4	5.1	-2.2	0.9	1.0	-0.3	-0.2
Waist circumference	1.2	4.2	9.4	1.0	2.5	3.1	2.1	-0.1
Fluid intelligence score	1.2	2.6	6.3	2.5	1.1	1.3	1.4	1.2
Pulse rate	1.2	2.0	6.2	-2.5	0.5	0.9	-1.2	-1.2
Birth weight	1.2	2.6	4.3	2.1	1.1	1.3	1.6	1.8
Hearing aid user	1.2	1.3	2.9	0.4	-1.6	-1.7	-0.5	-1.0
Number of operations (self-reported)	1.2	1.8	3.3	0.6	1.7	1.8	1.2	0.9
Bipolar Disorder (2018)	1.1	1.8	5.8	2.4	-1.0	-1.2	0.5	0.5
Coronary Artery Disease (CAD)	1.1	1.3	2.4	0.9	1.6	1.4	0.8	0.8
LDL Cholesterol	1.1	1.7	3.0	1.1	-1.6	-1.7	-0.9	-1.0
Frequency of depressed mood in last 2 weeks	1.1	1.6	5.0	-2.2	0.2	0.4	-0.9	-1.3
Impedance of leg (right)	1.1	5.5	11.0	-1.8	-2.7	-3.3	-2.2	-1.1
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	3.1	-0.7	1.8	1.3	1.0	0.3
Had menopause	1.1	1.4	2.8	1.0	0.9	0.2	1.6	1.7
Loud music exposure frequency	1.1	1.2	1.8	-1.0	-1.2	-0.7	-1.1	-1.4
Medication: Ventolin 100micrograms inhaler	1.1	1.4	4.2	-2.0	-0.5	-0.1	-1.3	-0.9
Leg fat percentage (right)	1.1	3.9	8.0	1.1	2.3	2.8	2.2	-0.2
Shortness of breath walking on level ground	1.1	1.3	2.2	-0.4	-1.0	-1.2	-1.5	-1.3
Heart disease (mother)	1.1	1.3	2.1	-0.3	1.4	1.4	0.9	1.2
Whole body fat mass	1.1	4.6	8.3	1.7	2.4	2.9	2.5	0.4
Leg fat-free mass (right)	1.1	5.8	7.7	2.8	2.4	2.3	2.7	1.7
Eye problems/disorders: Cataract	1.1	1.3	2.2	0.4	-1.4	-1.5	-1.0	-1.0
Leg predicted mass (right)	1.1	5.6	7.8	2.8	2.3	2.2	2.7	1.7
Blood White Count	1.0	7.5	14.1	-2.8	-2.2	-0.8	-3.8	-3.2
Townsend deprivation index at recruitment	1.0	1.4	2.0	-1.0	-1.2	-1.0	-1.4	-1.1
Maternal smoking around birth	1.0	1.5	4.4	-1.2	-0.9	-0.2	-0.9	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	7.1	-0.4	1.8	2.7	0.3	-0.8
Blood clot in the leg (DVT)	1.0	1.3	3.1	0.8	-0.2	-0.6	1.6	1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.7	1.9	0.2	0.3	1.2	0.9
Chest pain or discomfort	1.0	1.4	2.2	-1.4	1.5	1.5	0.1	0.8
Qualifications: nursing, teaching	1.0	1.6	4.2	1.1	1.2	2.1	0.7	0.8
Tinnitus: Yes, now most or all of the time	1.0	1.2	1.7	-0.8	-1.1	-1.2	-1.3	-1.0
Medication: Blood pressure	1.0	1.9	2.8	-0.4	1.6	1.1	1.7	1.7
Ever depressed for a whole week	1.0	1.2	3.5	-1.9	-0.2	0.3	-1.4	-0.6
Heel T-Score	0.9	7.2	17.0	-3.4	0.7	1.4	-2.2	-4.1
Medication: Co-codamol	0.9	1.1	3.0	-1.7	0.2	0.6	-0.4	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	6.2	0.3	1.8	2.5	0.7	-0.3
Qualifications: CSEs or equivalent	0.9	1.2	2.9	-1.3	-0.9	-0.4	-0.8	-1.7
Multivitamins +/- minerals	0.9	1.1	1.6	-1.3	-1.2	-0.9	-1.2	0.0
Chronic bronchitis/emphysema (father)	0.9	1.0	2.7	-1.6	0.2	0.9	-0.8	-0.9
Allergy	0.9	2.1	4.3	2.1	1.5	0.8	1.8	-0.1
Arm fat percentage (right)	0.9	3.4	6.8	1.5	2.1	2.6	2.0	-0.0
Peak expiratory flow (PEF)	0.9	2.1	5.9	2.4	0.8	0.6	1.6	1.1
Ever highly irritable/argumentative for 2 days	0.9	1.1	1.8	1.3	1.2	1.0	0.8	0.6
Number of full sisters	0.9	1.0	2.5	0.2	1.0	0.8	1.0	1.6
Guilty feelings	0.9	1.3	3.1	-1.8	-0.4	-0.3	-1.5	-1.0
Fractured/broken bones in last 5 years	0.9	1.2	3.2	0.9	-1.4	-1.8	-0.1	0.1
Age started oral contraceptive pill	0.9	1.2	3.6	1.9	0.1	-0.3	1.3	0.6
Verbal and Numeric Reasoning (VNR)	0.8	1.9	7.9	2.8	-0.0	0.2	1.0	0.8
Prostate Cancer	0.8	1.2	2.0	-0.4	-1.4	-1.0	-1.0	-1.3
Primary Biliary Cirrhosis	0.8	1.1	1.9	-0.3	-1.1	-1.4	-0.9	-1.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	3.3	0.1	1.2	1.8	0.6	0.2
Had other major operations	0.8	1.0	2.1	-1.1	0.4	0.7	-1.0	-1.4
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.1	-1.2	0.8	1.4	-0.6	-0.2
Father’s age at death	0.8	1.0	1.7	0.1	1.3	1.0	1.2	1.1
Worrier / anxious feelings	0.8	1.5	3.3	-1.8	-0.8	-0.7	-1.1	-1.4
Mouth/teeth dental problems: Dentures	0.8	1.3	4.7	-2.2	0.4	0.5	-0.3	-1.2
Exposure to tobacco smoke outside home	0.8	1.0	2.0	-0.7	-1.4	-1.1	-0.6	-1.0
Family relationship satisfaction	0.8	1.0	2.1	-1.4	-0.9	-0.6	-1.4	-0.2
Arm fat percentage (left)	0.8	3.2	7.4	1.2	2.1	2.7	1.7	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	3.3	1.8	-0.6	-0.6	0.4	0.0
Number of self-reported non-cancer illnesses	0.8	1.5	3.1	-1.8	-0.3	0.2	-1.4	-1.5
Leg fat percentage (left)	0.8	2.9	5.9	1.0	2.0	2.4	1.8	-0.5
Alzheimer’s Disease (in father)	0.7	0.7	1.3	-0.7	-1.0	-1.1	-0.6	-0.7
Lupus	0.7	1.1	3.8	-1.9	0.7	0.6	-0.5	-0.7
Systolic blood pressure, automated reading	0.7	2.0	4.3	-1.4	-0.8	-0.8	-1.6	-2.1
Medication: Lansoprazole	0.7	0.8	2.5	0.4	0.7	0.5	1.6	0.8
Glaucoma (self-reported)	0.7	0.8	1.1	-0.8	1.0	0.9	-0.7	-1.1
High blood pressure (siblings)	0.7	0.9	2.6	-1.6	0.6	0.8	-0.5	-0.9
Age at last live birth	0.7	1.1	2.2	1.5	-1.1	-1.3	-0.3	0.1
Osteoporosis (self-reported)	0.7	0.9	2.2	-0.8	-0.7	-0.2	-1.5	-1.0
Medication: Atorvastatin	0.7	0.8	1.8	-0.2	1.3	1.2	0.6	0.5
Diastolic blood pressure, automated reading	0.7	2.0	4.5	-1.2	-0.7	-0.7	-1.7	-2.1
Schizophrenia (2018)	0.6	1.3	3.3	-1.8	-0.7	-0.6	-1.5	-0.5
Crohns Disease (2017)	0.6	1.3	2.1	1.1	0.7	1.2	1.1	1.4
HbA1C	0.6	0.7	1.5	0.9	0.8	0.7	1.2	0.5
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.3	-0.7	0.9	1.2	0.0	0.9
Blood Platelet Count	0.6	6.6	10.8	-0.6	-3.3	-2.8	-2.8	-2.5
Waist Hip Ratio (WHR)	0.6	2.8	5.5	-2.3	-0.3	0.7	-1.7	-2.2
Systolic Blood Pressure	0.6	3.0	4.9	-1.7	-1.4	-1.5	-2.2	-1.7
Chronotype (morning person)	0.6	1.5	4.2	0.9	-1.0	-2.1	-0.8	0.7
Trunk fat mass	0.6	2.7	4.7	1.5	1.7	2.2	1.9	-0.1
Noisy workplace	0.6	0.8	1.8	-0.2	1.4	1.0	0.4	1.0
Lung cancer (father)	0.6	0.7	1.6	-1.3	-0.6	-0.5	-1.1	-0.2
Length of working week for main job	0.6	0.7	1.5	-1.2	-0.1	-0.2	-1.2	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.1	0.1	1.2	1.4	0.6	0.6
Smoking status: Current	0.6	0.9	1.9	-1.1	1.2	1.4	0.1	-0.0
Mean Putamen Volume	0.5	0.6	2.2	-0.2	0.3	0.7	-0.4	-1.5
Type 2 Diabetes (T2D) (2018)	0.5	1.0	3.3	-0.3	1.1	1.8	-0.4	-0.4
Diabetes (mother)	0.5	0.7	1.9	-0.9	-0.2	0.2	-0.8	-1.4
Hearing difficulty/problems with background noise	0.5	0.8	1.7	-0.8	-0.7	-0.1	-1.3	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.0	-0.3	-1.0	-0.7	-0.6	-1.0
Exposure to tobacco smoke at home	0.5	0.5	1.2	-0.2	1.0	1.1	0.6	-0.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.5	-0.4	-1.2	-0.8	-1.2	-1.0
Body fat percentage	0.5	2.0	4.3	0.8	1.5	2.1	1.5	-0.6
Age at first live birth	0.5	0.9	2.2	0.7	-1.5	-1.4	-0.4	-0.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.6	1.3	0.5	0.4	0.5	0.8
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.2	0.3	-1.1	-1.1	-0.1	0.6
Diabetes diagnosed by doctor	0.5	0.9	2.8	0.5	1.1	1.7	0.2	0.2
Ever taken oral contraceptive pill	0.5	0.5	1.6	1.3	-0.1	-0.6	0.5	0.6
High cholesterol (Self-reported)	0.5	0.9	2.2	0.3	1.2	1.5	0.6	0.7
Average weekly beer plus cider intake	0.5	0.7	1.5	-1.2	-0.1	-0.3	-0.7	-1.2
Age at First Birth	0.4	0.6	1.4	1.2	0.6	0.7	0.8	0.4
Body Mass Index (BMI) (2010)	0.4	0.5	0.8	0.9	-0.9	-0.8	0.4	-0.2
Crohns Disease (2012)	0.4	0.6	1.1	0.8	0.0	0.6	1.0	1.0
Height	0.4	7.1	11.5	3.4	-0.8	-2.5	2.5	3.3
Medication for hormone replacement therapy	0.4	0.5	0.9	-0.1	0.7	1.0	0.8	0.4
Current tobacco smoking	0.4	0.6	1.5	-1.2	0.6	0.9	-0.2	-0.5
Average weekly fortified wine intake	0.4	0.4	0.9	-0.3	1.0	0.8	0.7	0.1
Medication: Levothyroxine sodium	0.4	0.7	1.3	-0.5	-0.9	-0.3	-1.1	-1.1
Diabetes (self-reported)	0.4	0.6	1.8	0.3	1.0	1.3	0.0	0.2
Illnesses of siblings	0.4	0.6	1.3	1.1	-0.7	-1.0	-0.1	0.2
Illnesses of mother	0.4	0.5	1.3	1.1	-0.3	-0.9	-0.0	-0.2
Neck or shoulder pain in last month	0.4	0.5	1.5	-0.3	-0.5	-0.9	0.0	-1.2
Medication: Allopurinol	0.4	0.5	1.1	-0.6	-0.5	0.3	-0.8	-1.1
Mood swings	0.4	0.8	2.7	-1.0	0.2	0.0	-0.3	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.3	-1.1	-0.7	-0.7	-0.2	-0.1
Breast cancer (self-reported)	0.4	0.5	0.6	-0.6	-0.5	-0.8	-0.8	-0.7
Osteoarthritis (self-reported)	0.4	0.5	1.3	-1.1	0.9	0.3	0.5	0.1
Illnesses of father: None of the above (group 1)	0.4	0.5	1.6	1.3	-0.3	-0.5	0.5	0.3
Wears glasses or contact lenses	0.4	0.5	1.3	-1.1	-0.4	-0.0	-0.6	-0.7
Mother’s age at death	0.4	0.4	1.4	1.2	-0.4	-0.6	0.4	0.2
Commuting to job workplace: Public transport	0.4	0.5	1.0	1.0	0.4	0.7	0.8	0.5
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.9	-0.9	0.6	1.0	-0.0	-0.5
Illnesses of father: High blood pressure	0.4	0.5	1.3	-1.1	0.5	0.1	-0.5	-0.8
Alcohol drinker status: Never	0.4	0.5	1.8	1.3	-0.1	0.0	0.8	0.1
Irritability	0.4	0.6	2.0	-0.9	-0.2	-0.2	-0.4	-1.4
Bipolar Disorder or Schizophrenia	0.3	0.7	1.6	0.1	-1.2	-1.2	-0.8	-0.0
Alzheimer’s Disease (in mother)	0.3	0.3	1.0	-1.0	-0.7	-0.2	-0.3	-0.3
Alzheimer’s Disease (including proxy)	0.3	0.4	1.0	-1.0	-0.6	-0.4	-0.4	-0.6
Major Depression (MDD)	0.3	0.3	0.6	-0.7	0.6	0.8	-0.2	-0.0
Allergy or Eczema	0.3	0.7	1.0	-0.9	-1.0	-0.8	-1.0	0.4
Supplements: Glucosamine	0.3	0.4	1.0	-1.0	-0.2	-0.4	-0.5	-0.6
Heart attack	0.3	0.3	1.0	0.2	0.8	1.0	0.2	0.3
Medication: Ramipril	0.3	0.4	0.9	0.8	-0.7	-0.1	0.0	-0.9
Falls in the last year	0.3	0.3	0.9	0.0	0.7	0.3	0.5	1.0
Standing height	0.3	3.0	6.3	2.5	-0.2	-1.4	1.1	2.3
Pulse wave reflection index	0.3	0.3	1.1	1.1	-0.0	-0.3	0.7	0.1
Gout (self-reported)	0.3	0.4	1.5	-0.3	0.6	1.2	-0.0	-0.1
Medication: Seretide 50 evohaler	0.3	0.3	0.9	-1.0	-0.7	-0.2	-0.2	0.4
Illnesses of father: Heart disease	0.3	0.4	0.7	0.2	0.5	0.8	0.8	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.1	1.1	-0.6	-1.0	-0.4	-0.0
Basal cell carcinoma (self-reported)	0.3	0.4	1.5	-0.1	-0.4	0.0	-0.4	-1.2
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.9	0.3	0.7	0.9	0.3	0.3
Heart disease (siblings)	0.3	0.4	0.7	-0.0	0.8	0.8	0.8	0.5
HDL Cholesterol	0.2	0.3	1.2	-1.1	-0.3	-0.6	0.1	0.0
Lung FEV1/FVC ratio	0.2	1.0	2.7	1.2	0.8	0.4	1.6	0.4
Hair Pigment	0.2	4.7	6.2	-2.4	-1.9	-1.8	-2.5	-2.1
Hand grip strength (left)	0.2	0.6	1.8	-1.3	0.6	0.5	-0.2	0.6
Angina	0.2	0.3	0.6	-0.8	-0.5	-0.5	-0.3	-0.3
Diabetes (father)	0.2	0.2	0.7	-0.1	0.8	0.4	-0.1	0.3
Severe depression (siblings)	0.2	0.2	0.3	-0.4	0.5	0.6	-0.1	0.4
Trunk fat percentage	0.2	0.9	1.8	0.4	0.8	1.4	0.8	-1.0
Medication: Atenolol	0.2	0.3	0.6	-0.6	0.3	0.3	0.5	-0.8
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	0.3	-0.7	-0.9	-0.2	0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.6	-0.7	0.7	0.3	0.3	0.8
Eye problems/disorders: None of the above	0.2	0.3	1.0	-0.0	0.5	1.0	0.4	0.1
Medication: Blood pressure	0.2	0.3	0.6	0.8	-0.7	-0.3	-0.1	-0.7
Angina (self-reported)	0.2	0.2	0.7	-0.8	-0.4	-0.4	-0.2	-0.3
Medication: Omeprazole	0.2	0.3	0.6	-0.1	0.7	0.4	-0.3	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.6	0.5	0.5	0.6	0.2	-0.7
Alcohol intake frequency.	0.2	0.5	0.7	0.8	-0.8	-0.9	-0.5	0.7
Leg pain on walking	0.2	0.3	0.7	-0.9	0.5	0.5	-0.3	-0.1
Illnesses of siblings: Diabetes	0.2	0.3	0.5	-0.2	0.7	0.6	0.6	0.2
Friendships satisfaction	0.2	0.3	0.8	-0.3	-0.4	-0.4	-0.9	0.3
Eye problems/disorders: Glaucoma	0.2	0.3	0.8	-0.4	0.3	-0.0	-0.6	-0.9
Medication: Bendroflumethiazide	0.2	0.3	0.8	-0.7	-0.3	-0.4	-0.3	-0.9
Unable to work because of sickness or disability	0.2	0.2	0.5	-0.7	0.2	0.6	0.3	0.1
Myopia	0.2	0.3	0.7	-0.7	0.5	0.8	-0.2	0.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.3	-0.3	0.6	0.5	-0.3	-0.6
Alcohol drinker status: Previous	0.2	0.2	0.7	-0.8	0.0	0.3	-0.5	0.0
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	0.3	0.2	0.8	0.1	0.3
Breast Cancer	0.1	0.3	0.8	-0.4	0.3	0.4	0.6	0.9
Triglycerides	0.1	0.2	0.5	-0.7	0.2	0.2	-0.7	0.2
Cardiovascular Disease	0.1	0.4	1.0	1.0	0.3	0.3	0.7	0.4
Average weekly spirits intake	0.1	0.2	0.4	-0.4	-0.1	0.1	0.5	-0.6
Sensitivity / hurt feelings	0.1	0.1	0.6	-0.3	0.1	0.0	0.1	-0.8
Hand grip strength (right)	0.1	0.3	0.3	-0.6	0.6	0.6	-0.3	0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.2	0.5	0.4	0.2	0.4
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.9	-0.1	-0.5	-0.3	-0.5	1.0
Sitting height	0.1	0.9	2.3	1.3	-0.0	-0.3	0.4	1.5
Medication: Simvastatin	0.1	0.2	0.5	-0.2	-0.4	-0.3	-0.1	-0.7
Medication: Cholesterol lowering	0.1	0.2	0.4	0.3	-0.7	-0.4	-0.2	-0.4
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	0.2	-0.2	-0.1	-0.2	-0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.4	-0.3	-0.4	-0.1	0.3
Medication: Amlodipine	0.1	0.1	0.2	0.4	-0.5	0.0	-0.2	-0.2
Number of children fathered	0.1	0.1	0.3	-0.1	-0.3	-0.3	0.3	-0.5
Pulse wave peak to peak time	0.1	0.2	0.6	0.2	0.1	0.0	0.4	0.8
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.5	0.0	-0.3	0.0	0.7	0.2
Comparative height size at age 10	0.1	0.7	1.5	1.2	0.3	-0.6	0.5	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.3	-0.3	0.3	0.2	0.5	0.6
Medication: Lisinopril	0.1	0.2	0.5	0.2	0.3	0.4	-0.1	0.7
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	-0.2	0.6	0.6	-0.1	0.2
Ulcerative Colitis (UC)	0.0	0.1	0.1	-0.2	-0.3	-0.1	-0.3	-0.4
Tanning	0.0	0.3	0.6	-0.5	-0.5	-0.8	-0.3	-0.6
High blood pressure	0.0	0.1	0.2	0.4	-0.4	-0.3	0.2	-0.0
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.2	-0.1	-0.0	-0.0	-0.1	-0.5
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.2	0.2
Hypertension (Self-reported)	0.0	0.1	0.1	0.3	0.0	0.1	0.4	0.2
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	-0.0	-0.3	0.2	-0.0	-0.2

Hub : Genes

ZBTB37

Models

Trait associations