Hub : Genes

LIMK2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0620 0.0220 1.0e-07 0.078 0.054 0.068 0.058 0.060 1.0e-09 3.2e-07 1.2e-08 1.2e-07 7.2e-08
2 GTEx Esophagus Muscularis 0.0820 0.0410 2.6e-03 0.034 NA 0.001 NA 0.014 3.9e-03 NA 2.9e-01 NA 4.3e-02
3 GTEx Thyroid 0.0590 0.0250 1.2e-03 0.052 NA 0.034 NA 0.040 7.2e-05 NA 1.2e-03 NA 4.7e-04
4 YFS Blood 0.0360 0.0103 1.1e-14 0.042 0.052 0.057 0.053 0.057 1.1e-13 1.5e-16 3.6e-18 7.5e-17 4.5e-18
5 TCGA Brain Lower Grade Glioma 0.0569 0.0271 5.1e-08 0.063 0.064 0.059 NA 0.061 1.2e-07 9.3e-08 2.5e-07 NA 1.7e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 4.6 7.2 9.9 -3.1 -1.1 -3.1 2.8 -2.7
Bipolar Disorder or Schizophrenia 6.8 16.5 22.3 -4.7 -2.2 -3.9 4.7 -4.2
Depressed Affect (Nagel 2018) 0.1 0.3 0.9 -0.4 0.9 -0.1 -0.6 -0.1
Depression (Nagel 2018) 0.3 0.5 1.0 -1.0 0.5 -0.3 0.5 -1.0
Intelligence (Savage-Jansen 2018) 3.0 9.2 13.3 3.4 2.3 3.7 -2.7 2.9
Neuroticism (Nagel 2018) 1.1 2.5 4.1 1.6 1.4 1.3 -2.0 1.5
Schizophrenia (2018) 4.6 9.5 14.5 -3.5 -2.0 -2.5 3.8 -3.3
Schizophrenia vs Biploar Disorder 1.9 2.5 4.3 2.0 -0.1 2.1 -1.2 1.6
Worry (Nagel 2018) 0.8 1.7 3.1 1.4 1.0 1.0 -1.8 1.3
Alzheimer’s Disease (in mother) 2.7 3.2 5.0 2.1 1.3 1.5 -1.5 2.2
Alzheimer’s Disease (in father) 2.1 2.3 4.8 -0.6 -2.0 -0.7 2.2 -1.3
Alzheimer’s Disease (including proxy) 0.6 0.8 1.4 1.2 0.6 1.0 0.1 1.2
Crohns Disease (2017) 0.1 0.1 0.3 -0.1 -0.5 0.4 -0.1 -0.5
Irritable Bowel Disease (IBD) 0.2 0.6 0.9 0.7 0.9 0.6 -0.9 0.6
Ulcerative Colitis (UC) 1.3 2.5 4.1 1.6 2.0 0.8 -1.4 1.8
Major Depression (MDD) 0.1 0.1 0.2 -0.3 -0.4 0.3 -0.4 -0.3
Reaction Time 9.6 18.3 20.4 -4.5 -4.3 -3.8 4.2 -4.5
Verbal and Numeric Reasoning (VNR) 4.6 11.1 14.0 3.7 2.7 3.3 -3.4 3.4
Breast Cancer 0.1 0.2 0.5 0.5 -0.6 -0.3 0.7 -0.0
Ovarian Cancer 0.1 0.1 0.2 0.2 0.5 -0.4 -0.2 0.1
Prostate Cancer 0.9 1.3 1.7 -0.9 -1.1 -1.2 1.2 -1.3
Age at First Birth 1.3 1.9 4.3 1.9 0.2 2.1 -0.5 1.3
Bipolar Disorder (2011) 1.2 1.1 2.0 -1.4 0.0 -0.6 1.3 -1.3
Body Mass Index (BMI) (2010) 2.3 3.1 4.2 -1.6 -2.0 -1.7 1.6 -1.9
Coronary Artery Disease (CAD) 2.6 3.1 5.0 -1.9 -1.7 -1.5 1.3 -2.2
Crohns Disease (2012) 0.4 0.7 1.3 0.6 0.7 1.2 -1.0 0.6
Mean Putamen Volume 0.1 0.1 0.2 -0.4 0.1 -0.0 0.2 -0.3
Fasting Glucose 3.7 4.4 5.9 2.3 1.9 1.8 -2.1 2.4
HbA1C 0.9 1.0 1.7 1.2 -0.7 0.6 -1.3 1.1
HDL Cholesterol 1.4 2.3 3.2 1.7 1.0 1.3 -1.7 1.8
LDL Cholesterol 0.3 0.4 0.8 -0.9 0.2 -0.6 0.5 -0.7
Lupus 0.5 0.8 2.6 -0.5 -1.6 -0.3 0.6 -0.7
Neuroticism (2016) 0.9 1.3 2.7 1.6 -0.1 1.2 -1.2 1.1
Primary Biliary Cirrhosis 1.5 2.2 3.5 1.9 0.7 1.5 -1.3 1.8
Rheumatoid Arthritis 0.2 0.3 0.7 -0.2 -0.8 0.1 0.8 -0.4
Schizophrenia (2014) 4.1 9.0 11.6 -3.4 -2.2 -2.6 3.3 -3.3
Triglycerides 0.1 0.2 0.7 0.2 0.4 0.8 -0.4 0.2
Type 2 Diabetes (T2D) (2012) 1.3 1.5 2.4 1.6 0.4 1.4 -0.8 1.5
Ulcerative Colitis 0.9 1.3 3.6 0.7 1.9 -0.1 -0.9 1.2
Blood Eosinophil Count 5.9 45.8 96.6 -4.2 -9.8 -4.6 7.6 -6.0
Blood Platelet Count 0.2 2.2 3.9 1.8 0.7 1.7 -0.7 2.0
Blood Red Count 0.6 5.4 9.2 2.3 3.0 1.4 -2.4 2.2
Blood White Count 4.5 33.6 61.9 4.3 7.9 4.8 -5.6 5.8
Heel T-Score 1.8 14.5 19.1 -4.0 -2.5 -3.9 4.4 -4.0
BMI 1.6 9.5 12.2 -3.0 -3.5 -3.1 2.8 -3.1
Height 0.0 0.7 2.0 0.8 -0.7 1.4 0.3 0.3
Waist Hip Ratio (WHR) 6.2 27.9 31.6 5.6 4.6 5.2 -5.4 5.5
Systolic Blood Pressure 1.4 6.8 12.1 2.5 2.2 1.9 -3.5 2.8
Smoking Status 0.9 2.2 3.8 1.6 0.9 1.4 -2.0 1.4
Allergy or Eczema 0.5 1.3 2.6 1.6 -0.4 1.2 -0.9 1.1
Cardiovascular Disease 0.1 0.2 0.6 0.3 -0.7 -0.8 -0.3 -0.0
Hypothyroidism (self reported) 3.4 7.7 9.3 -2.8 -3.0 -2.5 2.5 -3.1
Respiratory disease 0.3 0.7 2.8 0.0 -1.7 -0.0 0.7 -0.4
Type 2 Diabetes (T2D) (2018) 0.8 1.6 3.5 1.5 0.3 1.9 -0.8 1.2
Lung FEV1/FVC ratio 0.3 1.6 2.2 -1.4 -1.2 -1.5 0.6 -1.5
Lung FVC 1.8 9.4 14.3 -2.5 -3.8 -2.4 3.2 -3.2
Neuroticism 1.5 3.6 5.3 2.0 1.5 1.9 -2.3 1.8
Chronotype (morning person) 1.8 4.1 6.2 -2.5 -1.1 -2.5 1.4 -2.3
Hair Pigment 0.7 20.3 25.8 5.1 3.4 4.6 -4.5 4.8
Tanning 0.1 1.1 2.2 -1.5 -0.2 -1.2 0.7 -1.2
Hand grip strength (left) 1.6 4.1 7.2 -1.5 -2.7 -1.2 2.3 -2.2
Number of treatments/medications taken 0.2 0.4 1.7 0.2 -1.3 -0.1 0.1 -0.4
Average weekly spirits intake 0.2 0.3 1.1 0.3 1.0 -0.3 -0.3 0.4
Sensitivity / hurt feelings 1.2 2.0 2.3 1.5 1.1 1.5 -1.5 1.5
Frequency of depressed mood in last 2 weeks 0.0 0.1 0.2 -0.1 -0.2 0.3 -0.0 -0.5
Hearing difficulty/problems: Yes 3.7 5.7 7.8 2.8 1.6 2.8 -2.0 2.5
Relative age of first facial hair 0.9 1.8 3.3 1.4 -0.1 1.8 -1.4 1.3
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.7 0.5 -0.6 0.5 -0.9 -0.1
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.6 0.8 0.2 -0.1 -0.2 0.7
Ever had hysterectomy (womb removed) 1.9 2.1 3.9 -1.3 -1.4 -1.0 2.0 -1.4
Systolic blood pressure, automated reading 0.7 2.1 3.4 1.2 1.6 0.9 -1.9 1.6
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 1.3 1.0 1.1 1.0 -0.8 1.1
Angina 0.8 1.0 1.2 -1.1 -1.0 -1.0 0.9 -1.1
Medication for hormone replacement therapy 1.5 1.6 5.0 -0.2 -2.2 -1.2 1.0 -0.8
Vitamin and mineral supplements 0.1 0.1 0.3 -0.0 0.5 -0.5 0.1 0.4
Supplements: Zinc 0.2 0.3 0.6 0.3 0.8 0.1 -0.6 0.4
Medication: Co-codamol 0.9 1.1 1.3 1.2 1.0 0.9 -1.0 1.1
Medication: Metformin 0.8 1.2 2.5 0.7 1.6 1.0 -0.9 1.0
Diabetes (father) 1.5 1.9 2.7 1.4 1.1 1.6 -1.6 1.1
Diabetes (mother) 1.0 1.3 1.8 -1.3 -0.8 -1.2 1.2 -1.1
Severe depression (siblings) 5.4 6.0 15.3 -1.4 -3.9 -2.0 2.3 -2.0
Pack years adult smoking proportion 0.4 0.7 1.0 -1.0 0.5 -1.0 0.8 -0.7
Impedance of leg (right) 5.1 24.9 30.3 4.8 5.5 4.4 -4.8 5.4
Leg fat-free mass (left) 1.5 8.0 12.6 -2.5 -3.5 -2.5 2.5 -3.0
Trunk fat percentage 0.5 1.9 2.8 1.1 1.6 0.7 -1.7 1.5
Hand grip strength (right) 1.7 4.7 6.9 -1.7 -2.6 -1.5 2.5 -2.3
Townsend deprivation index at recruitment 0.1 0.1 0.5 -0.0 0.7 0.0 -0.3 0.2
Current tobacco smoking 5.7 9.3 10.7 2.9 3.1 2.8 -3.3 3.1
Average weekly fortified wine intake 1.9 2.2 4.0 1.2 2.0 1.5 -1.2 1.4
Maternal smoking around birth 0.5 0.7 1.0 1.0 0.5 0.9 -0.9 0.8
Fed-up feelings 2.9 5.3 6.5 -2.5 -2.2 -2.0 2.1 -2.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.7 -1.3 -0.1 -0.7 0.7 -1.1
Relative age voice broke 0.5 0.7 1.3 1.1 -0.3 1.0 -0.7 0.8
Taking other prescription medications 0.8 1.2 2.3 1.5 -0.0 1.3 -0.9 1.0
Age when periods started (menarche) 7.8 18.7 22.0 4.0 4.4 4.2 -4.4 4.7
Bilateral oophorectomy (both ovaries removed) 1.0 1.1 2.1 1.5 0.1 1.4 -0.1 1.2
Heel bone mineral density (BMD) T-score, automated (left) 3.1 7.0 8.2 -2.6 -2.3 -2.7 2.9 -2.6
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 0.1 -0.5 -0.2 0.2 0.2
Qualifications: CSEs or equivalent 1.9 2.5 3.1 -1.7 -1.0 -1.7 1.8 -1.6
Serious illness, injury or assault to yourself 0.8 0.9 2.7 0.1 1.6 0.4 -1.3 0.5
High blood pressure 0.8 2.3 3.7 1.8 1.3 0.5 -1.9 1.7
Hayfever, allergic rhinitis or eczema 0.7 1.5 2.9 1.7 0.0 1.5 -1.1 1.2
Multivitamins +/- minerals 0.1 0.1 0.2 -0.2 -0.0 0.4 0.2 -0.2
Stomach or abdominal pain in last month 1.0 1.2 2.2 1.1 1.5 0.9 -0.7 1.2
Supplements: Glucosamine 0.3 0.4 1.2 -0.5 -1.1 -0.4 0.3 -0.8
Diverticular disease/diverticulitis (self-reported) 0.5 0.5 1.0 -0.8 1.0 -0.3 1.0 -0.0
Medication: Atenolol 0.0 0.0 0.1 0.0 0.3 0.2 -0.0 -0.0
Medication: Levothyroxine sodium 0.3 0.5 1.1 -0.6 -1.0 -0.6 0.5 -0.9
Sitting height 0.7 5.2 6.8 -2.0 -2.5 -1.7 2.6 -2.4
Chronic bronchitis/emphysema (father) 0.4 0.4 0.7 0.5 0.9 0.8 -0.4 0.6
High blood pressure (mother) 1.4 2.0 2.7 1.2 1.6 1.0 -1.5 1.7
Body mass index (BMI) 1.7 7.1 8.1 -2.7 -2.7 -2.8 2.2 -2.8
Impedance of leg (left) 5.5 26.7 35.2 5.0 5.9 4.4 -4.8 5.6
Leg predicted mass (left) 1.6 8.2 13.0 -2.5 -3.6 -2.5 2.6 -3.0
Trunk fat mass 0.0 0.2 0.5 0.3 0.4 0.1 -0.7 0.5
Waist circumference 0.1 0.2 0.6 0.4 0.1 0.3 -0.8 0.3
Number of incorrect matches in round 0.1 0.2 0.5 -0.2 -0.4 -0.7 0.1 -0.1
Past tobacco smoking 0.7 1.3 2.0 1.4 1.1 0.9 -0.9 1.4
Alcohol usually taken with meals 3.7 6.0 7.4 -2.7 -1.3 -2.6 2.6 -2.7
Nervous feelings 0.3 0.6 0.9 0.9 -0.7 0.7 -0.9 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.5 -0.6 -0.1 0.0 0.1 -0.7
Hearing difficulty/problems with background noise 1.5 2.3 3.6 1.9 0.5 1.9 -1.5 1.4
Hair/balding pattern: Pattern 2 2.7 3.4 3.8 1.9 1.8 1.7 -1.9 1.8
Had menopause 0.1 0.1 0.5 -0.0 0.1 -0.7 0.2 -0.2
Had other major operations 7.7 9.4 13.9 -3.3 -0.7 -3.7 3.5 -3.1
Forced vital capacity (FVC) 1.9 7.2 11.5 -2.0 -3.4 -1.7 3.0 -2.8
Heel bone mineral density (BMD) T-score, automated (right) 1.7 3.8 4.3 -2.0 -1.7 -2.1 2.0 -2.0
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 1.9 -1.3 -0.4 -1.4 0.7 -1.1
Qualifications: None of the above 0.0 0.1 0.3 0.1 -0.1 -0.6 -0.0 0.2
Financial difficulties in last 2 years 0.4 0.6 1.1 -0.5 -0.8 -0.6 0.6 -1.0
Mouth/teeth dental problems 2.2 3.4 4.5 1.8 2.1 1.4 -1.8 2.0
Heart attack 0.2 0.3 0.5 -0.6 -0.5 -0.4 0.3 -0.7
Allergy 0.8 1.9 3.5 -1.9 0.0 -1.7 1.2 -1.4
Pain all over the body in last month 4.2 4.5 6.1 2.5 1.7 1.8 -2.0 2.5
Diabetes (self-reported) 0.8 1.2 2.4 0.9 1.5 1.1 -0.9 0.9
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.5 0.4 -0.7 0.2 -0.7 0.0
Medication: Ramipril 0.1 0.2 0.2 -0.3 -0.2 -0.5 0.5 -0.4
Medication: Simvastatin 0.2 0.3 0.5 0.7 0.1 0.4 -0.7 0.5
Fluid intelligence score 1.2 2.5 3.1 1.8 1.5 1.7 -1.5 1.4
Illnesses of siblings 1.6 2.3 3.2 -1.8 -0.9 -1.1 1.8 -1.7
Neuroticism score 0.1 0.2 0.7 0.5 -0.0 0.4 -0.9 0.3
Weight 1.0 4.8 6.6 -2.0 -2.6 -2.1 1.9 -2.3
Impedance of arm (right) 5.2 24.0 29.4 4.6 5.3 4.4 -4.8 5.4
Arm fat percentage (right) 0.2 0.6 1.4 -0.9 -0.5 -1.2 0.4 -0.6
Trunk fat-free mass 2.3 13.0 17.7 -3.2 -4.2 -3.1 3.5 -3.9
Hip circumference 1.0 4.3 5.5 -2.3 -1.7 -2.1 1.8 -2.3
Time employed in main current job 0.1 0.1 0.5 0.0 -0.7 0.2 0.1 -0.2
Alcohol intake versus 10 years previously 4.2 6.2 8.7 -2.5 -1.9 -2.3 3.0 -2.7
Father’s age at death 2.8 3.8 11.0 0.9 3.3 1.3 -1.6 1.7
Worrier / anxious feelings 0.6 1.2 3.2 -0.9 -1.8 -0.9 0.2 -1.0
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.2 0.3 0.3 0.3 -0.5 0.2
Falls in the last year 0.2 0.2 0.5 -0.5 0.7 -0.4 0.1 -0.3
Hair/balding pattern: Pattern 3 0.9 1.3 2.1 1.3 0.4 0.9 -1.5 1.3
Number of live births 3.9 5.5 8.9 -2.7 -1.2 -3.0 1.8 -2.5
Forced expiratory volume in 1-second (FEV1) 2.8 9.4 12.1 -2.7 -3.5 -2.5 3.2 -3.3
Pulse rate 0.0 0.1 0.3 0.1 -0.6 -0.2 -0.1 -0.0
Happiness 1.6 2.0 2.6 -1.5 -1.2 -1.5 1.2 -1.6
Noisy workplace 4.1 5.1 6.0 -2.2 -2.0 -2.4 2.4 -2.3
Qualifications: A levels/AS levels or equivalent 0.4 0.9 2.1 0.5 1.5 0.9 -0.8 0.7
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.1 0.1 0.8 1.1 -0.7 0.2
Mouth/teeth dental problems: Dentures 0.7 1.2 1.5 -1.2 -1.2 -0.8 1.0 -1.2
Asthma 0.2 0.4 1.1 0.6 -1.1 0.7 0.1 0.2
Medication: Ibuprofen (e.g. Nurofen) 2.9 3.7 5.2 -2.3 -1.1 -2.3 1.9 -1.9
Medication: Cholesterol lowering 1.0 1.6 2.1 -1.2 -1.2 -1.1 1.3 -1.4
Depression (self-reported) 1.3 1.5 2.0 1.4 0.9 1.1 -1.4 1.3
Medication: Lansoprazole 5.0 5.7 8.1 2.8 1.9 2.0 -2.3 2.7
Prospective memory result 0.5 0.6 1.4 0.7 0.3 0.4 -1.2 0.9
Lung cancer (father) 1.2 1.5 3.5 0.7 1.9 0.3 -1.3 1.3
Illnesses of mother 1.3 1.7 2.6 -1.3 -0.8 -1.2 1.4 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 2.5 8.0 9.6 -2.7 -3.1 -2.2 3.0 -3.1
Pulse wave Arterial Stiffness index 2.6 3.1 4.3 2.0 1.4 1.5 -1.8 2.1
Impedance of arm (left) 5.6 25.8 30.9 4.7 5.4 4.7 -4.9 5.6
Arm fat mass (right) 0.5 2.2 3.0 -1.4 -1.6 -1.7 1.2 -1.4
Trunk predicted mass 2.3 13.2 18.0 -3.2 -4.2 -3.1 3.6 -3.9
Standing height 0.1 0.8 1.6 1.3 -0.1 1.2 -0.5 0.7
Length of working week for main job 1.6 1.8 2.4 -1.6 -1.1 -1.0 1.5 -1.5
Exposure to tobacco smoke at home 1.2 1.4 2.0 -1.4 0.5 -1.4 1.3 -0.9
Breastfed as a baby 0.6 0.8 1.5 1.2 -0.3 1.1 -0.5 0.9
Tense / ‘highly strung’ 0.3 0.4 1.0 0.6 0.1 0.7 -1.0 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.6 1.0 0.6 0.2 -1.3 1.1
Hair/balding pattern: Pattern 4 0.1 0.3 1.4 0.0 -1.2 0.3 -0.4 0.1
Birth weight of first child 4.1 7.4 12.5 -2.2 -3.5 -2.0 2.9 -2.7
Peak expiratory flow (PEF) 2.6 6.1 8.1 -2.0 -2.8 -1.9 2.8 -2.7
Pulse wave reflection index 1.8 2.3 4.0 1.4 2.0 1.0 -1.4 1.6
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.8 0.2 -1.3 -0.2 -0.4 -0.2
Loud music exposure frequency 0.9 1.0 1.7 -1.1 -0.2 -1.3 0.9 -1.0
Qualifications: O levels/GCSEs or equivalent 1.6 2.5 4.8 1.2 2.2 1.2 -1.6 1.6
Mouth/teeth dental problems: Bleeding gums 2.6 3.3 4.1 -1.8 -1.8 -2.0 1.7 -1.8
Blood clot in the leg (DVT) 1.7 2.2 3.5 -1.3 -1.9 -1.1 1.5 -1.5
Medication: Paracetamol 2.1 3.5 4.0 -1.9 -1.8 -1.8 1.9 -2.0
Headache pain in last month 1.6 2.8 5.1 -1.6 -0.6 -2.3 1.9 -1.5
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.3 0.1 -0.1 0.1 0.5 0.2
Glaucoma (self-reported) 2.9 3.4 5.0 1.8 1.7 1.5 -2.2 1.9
Gout (self-reported) 1.6 2.2 3.2 1.3 1.8 1.7 -1.2 1.3
Hypothyroidism/myxoedema (self-reported) 3.0 5.8 7.6 -2.2 -2.8 -2.2 2.1 -2.7
Medication: Amlodipine 0.1 0.1 0.3 0.3 -0.4 -0.2 -0.5 0.2
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.2 1.1 -0.6 0.7 -0.5 0.9
Birth weight 1.5 3.2 7.7 -1.1 -2.8 -0.2 2.1 -1.7
Chronic bronchitis/emphysema (mother) 0.0 0.0 0.2 -0.4 0.1 0.0 0.1 -0.1
High blood pressure (siblings) 0.5 0.7 1.0 0.9 0.3 0.7 -0.9 1.0
Forced vital capacity (FVC), Best measure 1.5 5.4 8.6 -1.8 -2.9 -1.4 2.8 -2.4
Body fat percentage 0.2 0.6 1.1 0.5 1.0 0.1 -1.0 0.8
Leg fat percentage (right) 0.1 0.2 0.4 0.1 0.7 -0.3 -0.6 0.5
Arm fat-free mass (right) 2.0 10.0 14.1 -2.7 -3.8 -2.9 3.0 -3.4
Exposure to tobacco smoke outside home 2.4 3.2 5.9 -2.4 -0.6 -1.7 1.9 -1.8
Comparative body size at age 10 2.3 6.3 8.6 -2.8 -2.0 -2.4 2.3 -2.9
Number of full brothers 1.0 1.2 2.9 -1.3 -0.1 -1.7 0.8 -0.8
Worry too long after embarrassment 0.4 0.8 1.3 1.0 0.2 0.8 -1.2 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 1.5 1.2 0.5 1.0 -1.2 1.2
Wheeze or whistling in the chest in last year 0.0 0.1 0.2 0.1 0.3 -0.5 -0.2 0.1
Number of children fathered 0.6 0.7 1.4 -0.9 0.2 -0.5 1.1 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.2 0.1 -0.5 -0.0 -0.2 0.1
Age at first live birth 0.1 0.2 0.5 0.2 -0.6 0.7 -0.3 -0.2
Pulse wave peak to peak time 3.4 4.0 5.6 -2.3 -1.5 -1.7 2.0 -2.4
Health satisfaction 2.9 3.8 5.3 -2.1 -1.4 -2.2 1.6 -2.3
Shortness of breath walking on level ground 0.2 0.2 0.4 0.5 -0.2 -0.1 -0.5 0.6
Qualifications: College or University degree 0.4 1.4 2.1 -1.1 -0.6 -1.4 1.2 -1.4
Eye problems/disorders: None of the above 1.1 1.3 2.2 -1.0 -0.4 -1.5 1.4 -1.0
Mouth/teeth dental problems: Loose teeth 1.9 2.2 3.7 -1.9 -0.4 -1.9 1.0 -1.7
Emphysema/chronic bronchitis 1.1 1.2 1.8 0.7 1.2 0.9 -1.3 1.2
Medication for pain relief, constipation, heartburn 5.6 9.6 11.4 3.0 3.2 3.0 -2.9 3.4
Neck or shoulder pain in last month 0.7 1.0 1.9 -1.1 0.6 -1.4 1.1 -0.8
Medication: Blood pressure 0.5 0.9 2.3 0.6 1.2 0.4 -1.5 0.6
Angina (self-reported) 0.4 0.6 0.7 -0.8 -0.8 -0.7 0.7 -0.8
Migraine (self-reported) 0.1 0.1 0.4 0.1 -0.6 -0.1 0.2 0.1
Medication: Ibuprofen 2.2 2.6 3.7 -1.9 -1.3 -1.6 1.6 -1.7
Medication: Allopurinol 2.1 2.8 4.0 1.4 2.0 1.7 -1.5 1.6
Medication: Omeprazole 0.3 0.4 1.3 0.4 -1.1 0.6 -0.0 -0.1
Medication: Seretide 50 evohaler 0.9 1.0 1.6 1.1 0.1 1.1 -1.3 1.1
Mean time to correctly identify matches 8.9 17.0 18.6 -4.3 -4.3 -3.6 4.0 -4.3
Heart disease (mother) 1.0 1.2 1.8 -1.2 -1.1 -0.7 0.9 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 0.7 -0.8 0.1 -0.8 0.7 -0.8
Whole body fat mass 0.0 0.1 0.2 -0.2 -0.3 -0.5 -0.2 -0.1
Leg fat mass (right) 0.1 0.6 1.1 -0.8 -0.8 -1.0 0.3 -0.7
Arm predicted mass (right) 1.5 7.5 11.1 -2.2 -3.3 -2.5 2.6 -2.9
Pulse rate, automated reading 2.0 6.3 9.0 2.7 1.5 2.4 -3.0 2.6
Alcohol intake frequency. 2.4 5.6 6.8 -2.2 -2.3 -2.6 2.4 -2.3
Comparative height size at age 10 0.1 0.4 1.3 0.5 -1.1 0.7 0.1 -0.1
Number of full sisters 1.7 2.0 3.2 -1.8 -0.1 -1.6 1.5 -1.4
Suffer from ‘nerves’ 2.8 4.4 6.0 2.3 1.4 1.8 -2.3 2.4
Overall health rating 0.0 0.1 0.4 0.0 -0.6 0.0 -0.0 -0.2
Chest pain or discomfort 0.5 0.7 1.7 -0.7 -0.4 -1.3 0.7 -0.9
Had major operations 0.6 0.8 2.3 0.9 0.1 1.5 -0.5 0.6
Age at last live birth 0.3 0.5 1.0 -0.8 -0.8 -0.2 0.4 -1.0
Family relationship satisfaction 0.1 0.1 0.4 -0.1 -0.6 -0.2 0.0 -0.5
Leg pain on walking 0.5 0.6 1.8 0.3 1.4 0.5 -0.7 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.3 -0.2 0.5 0.1 0.1 0.3
Commuting to job workplace: Car/motor vehicle 0.4 0.5 0.6 -0.4 -0.7 -0.8 0.8 -0.8
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 0.0 -0.4 -0.4 0.5 0.2
Medication: Aspirin 0.3 0.3 0.5 -0.6 -0.4 -0.6 0.4 -0.7
Supplements: Vitamin C 1.3 1.5 2.2 -1.4 -0.2 -1.5 1.1 -1.4
Knee pain experienced in last month 1.0 1.5 2.0 0.9 1.4 1.2 -1.2 1.3
Hypertension (Self-reported) 0.8 2.2 3.1 1.6 1.5 0.4 -1.8 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.1 0.6 0.6 1.1 -0.4 0.3
Illnesses of father: Heart disease 0.6 0.9 3.2 -0.4 -1.8 -0.1 0.8 -0.7
Illnesses of siblings: Diabetes 0.5 0.6 1.1 1.1 0.7 -0.2 -0.8 0.9
Smoking status: Previous 1.4 2.1 3.0 -1.7 -1.2 -1.5 1.2 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 2.8 -0.6 -1.7 -0.7 0.7 -1.0
Whole body fat-free mass 2.1 12.1 17.5 -3.0 -4.2 -3.0 3.3 -3.7
Leg fat-free mass (right) 1.6 8.6 12.6 -2.6 -3.5 -2.6 2.7 -3.1
Arm fat percentage (left) 0.1 0.2 0.6 -0.6 -0.3 -0.8 0.1 -0.3
Average weekly red wine intake 0.4 0.5 1.6 0.3 1.3 0.6 -0.8 0.4
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.5 0.5 0.0 0.3 -0.6 0.7
Mood swings 0.3 0.6 1.0 -1.0 -0.4 -0.8 0.6 -1.0
Loneliness, isolation 0.0 0.0 0.1 -0.1 -0.0 0.3 -0.1 -0.1
Long-standing illness, disability or infirmity 1.7 2.5 4.0 2.0 0.9 1.4 -1.9 1.6
Ever had bowel cancer screening 4.0 4.7 6.3 2.2 2.5 1.7 -2.1 2.3
Diabetes diagnosed by doctor 0.7 1.1 2.1 0.8 1.4 1.1 -0.8 0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.2 -1.1 -0.3 -0.8 0.3 -0.9
Friendships satisfaction 1.6 1.9 2.7 -1.4 -0.9 -1.5 1.4 -1.6
Qualifications: nursing, teaching 0.1 0.2 0.6 0.3 -0.1 0.7 0.0 0.4
Commuting to job workplace: Walk 2.5 2.7 4.4 1.4 1.6 1.4 -2.1 1.5
Eye problems/disorders: Cataract 0.8 0.9 1.2 0.8 0.8 1.1 -1.1 1.0
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.4 0.9 -0.2 1.2 -0.4 0.5
Medication for cholesterol 0.3 0.5 1.7 0.1 0.8 1.3 -0.2 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.2 -0.2 -0.1 0.4 -0.5 0.2
Back pain experienced in last month 0.3 0.5 1.5 -0.5 0.2 -1.2 0.3 -0.6
Mineral and other dietary supplements 0.9 1.2 1.6 1.2 1.0 1.2 -0.7 1.3
Breast cancer (self-reported) 0.4 0.5 1.3 -0.1 1.2 -0.1 -0.7 0.8
Asthma (self-reported) 0.3 0.7 2.8 0.1 -1.7 0.1 0.6 -0.3
Osteoporosis (self-reported) 0.6 0.8 2.1 0.2 1.4 -0.1 -1.2 0.5
Osteoarthritis (self-reported) 0.1 0.1 0.3 0.4 -0.0 0.5 -0.3 0.2
Medication: Aspirin 0.1 0.2 0.3 -0.5 -0.3 -0.5 0.3 -0.5
Medication: Gliclazide 0.6 0.7 3.2 0.2 1.8 -0.0 -0.4 0.4
Illnesses of father: None of the above (group 1) 0.4 0.4 0.9 -0.9 0.0 -0.9 0.4 -0.6
Smoking status: Current 4.4 6.9 8.1 2.6 2.5 2.5 -2.8 2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.5 3.2 3.8 -1.9 -1.5 -1.8 1.8 -1.9
Whole body water mass 2.2 12.5 18.0 -3.1 -4.2 -3.1 3.4 -3.7
Leg predicted mass (right) 1.6 8.6 12.2 -2.6 -3.5 -2.6 2.7 -3.1
Arm fat mass (left) 0.6 2.4 3.1 -1.5 -1.8 -1.7 1.2 -1.5
Number of self-reported non-cancer illnesses 0.2 0.4 1.7 0.5 -1.3 -0.1 -0.0 -0.1
Average weekly champagne plus white wine intake 0.3 0.4 0.7 -0.8 -0.6 -0.0 0.5 -0.8
Miserableness 0.6 1.0 2.0 -1.4 -0.4 -1.2 0.3 -1.2
Guilty feelings 0.1 0.2 0.6 0.4 -0.8 0.3 0.2 -0.2
Wears glasses or contact lenses 0.3 0.3 0.5 0.5 0.6 0.2 -0.7 0.5
Ever taken oral contraceptive pill 0.4 0.5 0.7 -0.6 -0.9 -0.3 0.7 -0.8
Hearing aid user 0.2 0.2 0.8 0.0 -0.9 0.1 0.1 -0.3
Mother’s age at death 1.9 2.4 4.3 -2.1 -0.5 -0.9 1.8 -1.8
Financial situation satisfaction 0.2 0.3 0.8 -0.5 0.9 -0.3 -0.6 -0.3
Tinnitus: Yes, now most or all of the time 0.8 0.9 1.7 -0.8 -0.4 -1.3 1.0 -1.0
Commuting to job workplace: Public transport 1.0 1.2 1.6 1.3 0.8 1.2 -1.1 1.1
Eye problems/disorders: Glaucoma 0.6 0.7 1.3 1.0 0.6 0.5 -1.2 0.8
Medication: Blood pressure 0.1 0.1 0.3 0.5 0.0 -0.4 -0.1 0.3
Pain type(s) experienced in last month: Hip pain 0.1 0.2 0.8 0.1 0.9 -0.3 0.1 0.1
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.2 -0.5 -0.3 -0.5 0.0 -0.3
High cholesterol (Self-reported) 0.9 1.6 2.4 -1.4 -0.9 -1.5 1.1 -1.3
Medication: Bendroflumethiazide 1.0 1.6 2.4 1.4 1.3 0.8 -1.6 1.1
Medication: Paracetamol 1.1 1.7 2.1 -1.3 -1.2 -1.3 1.4 -1.3
Medication: Lisinopril 0.9 1.1 1.7 1.2 0.8 0.4 -1.3 1.3
Medication: Atorvastatin 2.4 3.0 5.1 -1.9 -0.4 -2.3 1.7 -1.8
Illnesses of father: High blood pressure 0.2 0.3 0.7 -0.6 0.1 -0.8 0.3 -0.6
Alcohol drinker status: Never 0.2 0.2 0.6 -0.5 0.4 -0.8 0.4 -0.2
Ever smoked 0.6 1.0 1.5 -1.2 -0.9 -0.8 1.0 -1.2
Basal metabolic rate 2.0 10.9 15.4 -2.9 -3.9 -3.0 3.1 -3.5
Leg fat percentage (left) 0.1 0.3 0.8 0.2 0.9 -0.4 -0.6 0.5
Arm fat-free mass (left) 2.6 13.3 17.8 -3.1 -4.2 -3.4 3.5 -3.9
Number of operations (self-reported) 0.9 1.4 2.8 -1.2 0.1 -1.3 1.7 -1.1
Average weekly beer plus cider intake 2.8 4.0 4.9 2.0 1.4 2.2 -2.2 2.1
Irritability 0.5 0.9 1.6 0.9 0.8 1.0 -1.3 0.5
Risk taking 0.2 0.3 1.0 0.3 1.0 0.3 -0.6 0.3
Ever had prostate specific antigen (PSA) test 5.1 5.9 10.1 2.5 1.5 3.2 -2.3 2.3
Fractured/broken bones in last 5 years 0.0 0.1 0.3 0.1 -0.0 0.5 0.0 0.1
Age started oral contraceptive pill 0.2 0.3 0.5 -0.4 -0.7 -0.4 0.6 -0.4
Diastolic blood pressure, automated reading 0.8 2.5 3.6 1.4 1.4 1.6 -1.9 1.6
Ever depressed for a whole week 0.4 0.5 1.6 -0.3 -1.3 -0.6 0.3 -0.6
Unable to work because of sickness or disability 0.1 0.2 0.4 0.6 -0.2 0.6 -0.3 0.2
Commuting to job workplace: Cycle 0.3 0.4 0.8 -0.6 -0.2 -0.9 0.6 -0.4
Myopia 0.9 1.3 2.1 1.1 1.0 0.9 -1.4 1.1
Vascular/heart problems diagnosed by doctor 0.9 2.4 3.9 -1.7 -1.3 -0.7 2.0 -1.7
Cholesterol lowering medication 0.5 0.7 2.6 -0.6 0.1 -1.6 0.4 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.6 0.6 -0.4 0.8 -0.5 0.2
Pain experienced in last month 0.7 1.2 3.1 1.0 -0.3 1.8 -1.1 0.9
Supplements: Calcium 0.1 0.1 0.4 0.6 -0.3 -0.3 -0.2 0.3
Basal cell carcinoma (self-reported) 1.1 1.3 1.9 -1.1 -1.4 -1.1 0.8 -1.2
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.7 -0.6 -0.7 -0.5 0.3 -0.8
Deep venous thrombosis (DVT) (self-reported) 2.0 2.5 3.9 -1.4 -2.0 -1.3 1.6 -1.6
Heart disease (siblings) 0.1 0.1 0.2 0.3 -0.2 -0.0 -0.4 0.1
Alcohol drinker status: Previous 0.4 0.4 1.0 -0.0 1.0 -0.9 -0.5 0.5
Pack years of smoking 0.2 0.3 0.6 -0.6 0.8 -0.6 0.4 -0.2
Impedance of whole body 5.6 28.7 35.4 5.0 5.9 4.8 -5.1 5.8
Leg fat mass (left) 0.1 0.5 1.2 -0.7 -0.7 -1.1 0.4 -0.6
Arm predicted mass (left) 2.5 13.0 16.2 -3.1 -4.0 -3.5 3.5 -3.8