Hub : Genes

DEPDC5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0400	0.0250	0.04900	0.051	-0.001	0.007	0.019	0.036	7.0e-07	0.45000	4.2e-02	0.00220	2.7e-05
2	GTEx	Cells Transformed fibroblasts	0.0940	0.0440	0.00320	-0.002	NA	0.010	NA	0.002	5.1e-01	NA	5.9e-02	NA	2.0e-01
3	GTEx	Colon Transverse	0.1020	0.0510	0.00850	0.018	NA	0.005	NA	0.019	4.6e-02	NA	1.8e-01	NA	4.3e-02
4	NTR	Blood	0.0197	0.0080	0.00025	0.019	0.011	0.013	0.011	0.013	5.2e-07	0.00012	3.8e-05	0.00012	2.4e-05
5	TCGA	Breast Invasive Carcinoma	0.0253	0.0129	0.00041	0.010	0.010	0.007	NA	0.009	3.6e-03	0.00250	1.3e-02	NA	4.9e-03
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0930	0.0540	0.00480	0.013	0.018	0.003	NA	0.014	5.5e-02	0.03100	1.9e-01	NA	4.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	2.3	3.7	6.7	2.1	1.8	-0.6	0.8	-2.6	2.5
Bipolar Disorder or Schizophrenia	1.2	3.0	6.2	2.5	0.7	-1.6	-1.0	-1.2	2.5
Depressed Affect (Nagel 2018)	1.4	3.0	4.8	1.7	1.2	-1.3	1.6	-2.2	2.2
Depression (Nagel 2018)	2.9	4.3	11.9	2.0	1.7	-1.6	1.1	-1.8	3.5
Intelligence (Savage-Jansen 2018)	0.9	2.8	4.7	-0.7	-1.7	2.1	1.8	2.2	-1.2
Neuroticism (Nagel 2018)	1.1	2.6	6.0	0.6	1.5	-0.3	2.4	-1.8	1.8
Schizophrenia (2018)	0.8	1.7	3.7	1.5	-0.5	-1.7	-1.9	0.5	1.1
Schizophrenia vs Biploar Disorder	1.5	2.0	4.0	-0.7	-1.2	1.0	-1.4	2.0	-1.7
Worry (Nagel 2018)	1.1	2.2	6.0	0.6	0.7	0.3	2.4	-1.8	1.8
Alzheimer’s Disease (in mother)	0.6	0.7	2.2	-0.6	-0.5	1.5	0.8	0.7	-0.4
Alzheimer’s Disease (in father)	1.2	1.4	3.6	0.5	-0.4	-1.4	-1.9	0.9	-1.1
Alzheimer’s Disease (including proxy)	0.3	0.4	1.0	-0.0	-0.4	0.7	-0.2	0.8	-1.0
Crohns Disease (2017)	0.6	1.2	3.9	-1.2	0.8	0.8	-0.2	0.8	-2.0
Irritable Bowel Disease (IBD)	0.4	0.8	3.2	0.1	1.8	1.0	0.4	-0.0	-0.7
Ulcerative Colitis (UC)	0.6	1.1	2.7	1.3	1.6	0.2	1.0	-1.1	0.5
Major Depression (MDD)	0.6	0.7	1.3	0.5	-0.8	-1.1	0.8	-0.3	1.0
Reaction Time	2.6	4.9	12.7	1.3	-2.6	-2.1	-3.6	1.7	-1.0
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.5	-0.6	-1.5	1.3	1.0	1.6	-0.9
Breast Cancer	0.4	0.9	1.9	0.3	0.4	-1.1	-1.3	1.4	-0.2
Ovarian Cancer	0.2	0.3	1.2	-0.0	-0.4	1.1	0.0	0.4	-0.2
Prostate Cancer	0.4	0.5	1.6	0.0	1.0	1.3	-0.7	-0.3	-0.2
Age at First Birth	2.0	2.9	11.9	-1.0	-1.0	-0.3	-1.2	3.5	-1.4
Bipolar Disorder (2011)	2.6	2.5	5.9	2.4	1.5	-0.6	1.4	-1.6	1.5
Body Mass Index (BMI) (2010)	0.8	1.1	3.5	0.5	0.6	0.8	-1.9	1.4	-0.1
Coronary Artery Disease (CAD)	0.5	0.6	0.9	-0.0	-0.7	-0.7	-0.9	-0.8	-1.0
Crohns Disease (2012)	0.6	1.0	3.8	-0.7	0.6	1.0	0.3	0.7	-1.9
Mean Putamen Volume	0.2	0.2	0.4	-0.5	-0.5	-0.3	-0.1	-0.4	0.6
Fasting Glucose	1.5	1.8	7.2	-0.2	0.0	1.9	2.7	-0.3	-0.0
HbA1C	1.9	2.1	5.4	-1.0	1.2	1.5	1.2	-2.3	1.1
HDL Cholesterol	1.2	2.1	8.5	-0.8	-1.1	0.7	-0.4	1.2	-2.9
LDL Cholesterol	1.4	2.3	5.0	0.7	1.4	0.1	1.0	-2.2	2.2
Lupus	1.2	1.9	4.5	-1.5	-2.1	-1.8	-0.9	0.6	-0.4
Neuroticism (2016)	0.6	0.9	2.1	-1.5	-0.4	-0.6	-1.1	0.7	-1.1
Primary Biliary Cirrhosis	0.3	0.4	0.9	1.0	0.5	0.5	0.2	-0.2	-1.0
Rheumatoid Arthritis	0.4	0.5	1.5	1.2	-0.4	-0.8	-0.1	-0.7	-0.5
Schizophrenia (2014)	0.9	2.0	4.0	1.5	-0.2	-2.0	-1.8	0.6	1.4
Triglycerides	0.8	1.3	2.3	0.3	1.2	0.8	1.5	-1.0	1.5
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.2	-0.4	-0.4	1.1	-0.0	1.0	-1.0
Ulcerative Colitis	0.2	0.3	1.7	1.3	0.0	0.3	-0.3	0.4	-0.0
Blood Eosinophil Count	3.0	23.0	60.5	-3.3	-5.0	-3.4	-7.8	4.8	-2.8
Blood Platelet Count	0.3	3.5	7.4	-2.5	-0.7	1.9	-1.2	1.2	-2.7
Blood Red Count	0.1	1.1	2.7	1.6	0.5	0.5	-0.6	1.4	1.0
Blood White Count	1.7	12.6	31.1	2.4	2.8	3.2	5.6	-3.8	2.5
Heel T-Score	0.8	6.0	12.0	3.5	0.1	-2.9	-3.3	2.0	0.8
BMI	1.0	6.1	17.3	-1.2	-3.1	-1.4	-4.2	1.0	-2.3
Height	0.2	3.8	12.0	1.7	2.2	1.6	-0.1	3.5	0.1
Waist Hip Ratio (WHR)	1.1	5.1	19.0	1.5	1.5	2.5	4.4	0.3	0.9
Systolic Blood Pressure	1.6	8.0	20.5	-4.5	1.7	2.3	2.3	-3.1	-2.1
Smoking Status	0.9	2.2	5.1	-1.0	2.3	1.7	1.2	-1.3	1.0
Allergy or Eczema	3.0	7.8	19.4	0.7	-4.2	0.7	-2.2	4.4	-2.0
Cardiovascular Disease	0.4	1.3	6.8	-2.6	0.1	-0.5	-0.9	0.0	-0.3
Hypothyroidism (self reported)	1.1	2.5	7.2	-0.5	0.6	-2.2	0.1	-2.7	1.6
Respiratory disease	1.2	2.6	6.7	1.7	-2.1	-0.8	-0.8	2.6	0.4
Type 2 Diabetes (T2D) (2018)	0.8	1.4	4.7	0.2	0.1	1.8	-0.4	2.2	-0.7
Lung FEV1/FVC ratio	0.3	1.5	3.7	1.0	0.3	-1.6	1.1	-0.8	1.9
Lung FVC	1.2	6.2	21.1	-0.7	-0.7	-1.7	-4.6	3.2	-1.5
Neuroticism	0.7	1.8	4.4	0.3	1.2	-0.1	2.1	-1.6	1.5
Chronotype (morning person)	0.3	0.7	2.6	-0.6	0.5	-0.7	-1.6	-0.4	-0.5
Hair Pigment	0.1	3.9	15.5	0.6	-0.3	3.9	2.5	0.8	-0.8
Tanning	0.1	1.3	2.7	0.6	1.2	1.3	1.1	-1.6	0.8
Hand grip strength (left)	0.9	2.3	6.5	-1.1	-0.5	0.8	-2.6	1.3	-1.8
Number of treatments/medications taken	0.1	0.2	0.5	0.3	-0.1	0.4	-0.3	0.2	0.7
Average weekly spirits intake	1.3	1.7	4.7	0.5	1.7	1.0	1.1	-2.2	-0.2
Sensitivity / hurt feelings	0.7	1.1	2.8	0.1	1.2	0.6	0.8	-1.7	1.3
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.4	0.4	1.1	-0.2	-0.1	-0.6	1.5
Hearing difficulty/problems: Yes	1.5	2.3	8.6	0.9	0.7	1.6	0.0	2.9	-1.2
Relative age of first facial hair	0.5	1.1	3.8	-0.4	-0.9	0.1	0.0	1.3	-1.9
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	3.5	-1.8	0.7	0.6	1.1	-1.9	1.4
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.7	1.2	1.6	0.6	-0.5	0.9	0.1
Ever had hysterectomy (womb removed)	0.8	0.9	2.0	0.9	-0.4	-0.8	-1.4	-0.4	-1.3
Systolic blood pressure, automated reading	0.7	2.0	6.8	-2.6	1.0	0.6	0.9	-1.4	-1.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.5	1.2	0.6	0.5	1.0	-0.2	1.0
Angina	0.4	0.6	1.1	1.0	0.5	-0.0	-1.1	0.9	-0.1
Medication for hormone replacement therapy	2.0	2.2	4.6	0.4	-1.2	0.7	-2.1	2.1	-1.4
Vitamin and mineral supplements	0.3	0.4	1.0	0.5	0.8	0.8	0.2	-1.0	0.0
Supplements: Zinc	0.6	0.6	2.5	-0.4	0.7	1.6	0.3	0.7	0.0
Medication: Co-codamol	0.9	1.0	2.2	1.0	1.0	0.3	0.6	1.1	1.5
Medication: Metformin	1.3	1.9	6.0	1.1	1.5	2.4	1.1	-0.9	0.4
Diabetes (father)	0.3	0.4	0.8	0.6	0.0	0.0	0.8	0.9	0.6
Diabetes (mother)	0.9	1.1	2.5	1.4	1.6	-0.7	-0.1	-1.1	0.9
Severe depression (siblings)	3.9	4.3	8.5	-1.3	-2.1	-1.3	-2.9	1.1	-2.9
Pack years adult smoking proportion	1.2	1.9	3.7	1.9	0.6	0.9	1.0	-1.9	1.4
Impedance of leg (right)	1.6	7.6	25.3	0.6	3.3	2.3	5.0	-1.2	1.6
Leg fat-free mass (left)	0.5	2.5	8.3	-1.0	-1.8	-0.8	-2.9	0.6	-1.2
Trunk fat percentage	0.3	1.2	3.9	-0.3	0.5	0.4	1.4	-2.0	0.9
Hand grip strength (right)	0.4	1.0	3.4	-0.7	-0.0	0.8	-1.8	1.1	-0.3
Townsend deprivation index at recruitment	0.2	0.3	1.3	-1.1	-0.3	0.2	0.2	-0.8	0.2
Current tobacco smoking	2.9	4.7	11.1	-0.7	2.6	3.3	2.6	-1.1	1.6
Average weekly fortified wine intake	0.7	0.8	4.0	0.8	-0.3	0.3	2.0	0.4	0.1
Maternal smoking around birth	0.1	0.2	0.6	-0.2	-0.1	-0.5	0.8	0.1	-0.5
Fed-up feelings	1.0	1.8	6.8	0.2	0.0	-2.6	-0.8	-1.8	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	5.0	1.3	1.2	-1.0	0.3	-1.8	2.2
Relative age voice broke	1.7	2.6	6.6	-0.8	-1.4	0.7	-1.7	1.7	-2.6
Taking other prescription medications	0.3	0.5	1.6	1.3	-0.8	-0.1	0.3	0.8	-0.1
Age when periods started (menarche)	2.4	5.8	15.9	0.6	2.3	4.0	3.3	-1.2	1.1
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	7.2	0.8	2.0	2.7	-0.3	0.6	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	9.9	1.3	-0.4	-1.8	-3.1	1.1	-0.8
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	5.2	-2.3	-0.2	-1.2	-1.0	-0.6	-0.4
Qualifications: CSEs or equivalent	1.4	1.9	5.8	1.0	0.8	-2.4	-0.2	-1.9	0.2
Serious illness, injury or assault to yourself	2.8	3.3	7.7	0.0	1.3	1.3	2.8	-2.8	1.2
High blood pressure	0.3	0.9	3.5	-1.9	0.4	0.1	0.5	-0.9	-0.6
Hayfever, allergic rhinitis or eczema	1.9	4.1	11.5	0.2	-3.0	0.2	-1.5	3.4	-1.5
Multivitamins +/- minerals	0.3	0.4	1.8	0.2	-0.1	-1.3	0.7	-0.3	0.1
Stomach or abdominal pain in last month	0.7	0.8	2.6	1.3	1.6	0.5	0.5	0.1	-0.4
Supplements: Glucosamine	0.5	0.7	2.2	0.5	-0.4	0.2	-1.1	1.5	-0.2
Diverticular disease/diverticulitis (self-reported)	1.7	2.1	3.8	1.2	1.7	0.0	0.9	-1.9	1.9
Medication: Atenolol	0.9	1.1	2.1	1.3	1.5	0.0	0.6	-0.9	1.3
Medication: Levothyroxine sodium	1.3	2.2	4.1	0.2	0.6	-1.7	1.7	-2.0	1.7
Sitting height	0.1	0.6	2.4	-0.3	0.2	-0.6	-1.5	0.1	-0.8
Chronic bronchitis/emphysema (father)	1.3	1.6	4.1	1.8	2.0	-0.2	0.9	-0.3	1.1
High blood pressure (mother)	0.6	0.8	2.6	0.3	1.2	0.6	1.6	-0.5	-0.5
Body mass index (BMI)	0.6	2.4	8.6	-0.6	-1.6	-1.4	-2.9	0.1	-1.1
Impedance of leg (left)	1.8	8.8	26.4	1.5	3.5	2.1	5.1	-1.4	2.3
Leg predicted mass (left)	0.5	2.5	8.3	-0.9	-1.8	-0.8	-2.9	0.7	-1.2
Trunk fat mass	0.1	0.3	1.4	-0.2	0.0	-0.0	0.5	-1.2	0.6
Waist circumference	0.0	0.1	0.3	0.2	-0.1	0.0	0.3	-0.5	-0.0
Number of incorrect matches in round	0.5	0.8	1.8	-1.3	-0.2	-1.3	-0.9	-0.7	-0.3
Past tobacco smoking	0.5	0.9	2.8	0.7	-1.0	1.1	-0.1	1.7	-0.2
Alcohol usually taken with meals	1.0	1.7	6.3	1.2	0.2	-2.5	-1.4	-0.0	0.6
Nervous feelings	0.7	1.4	3.5	-1.9	-1.2	-0.6	1.1	-1.1	-0.7
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.2	8.4	2.4	1.6	-0.3	1.5	-0.9	2.9
Hearing difficulty/problems with background noise	0.8	1.3	5.9	-0.1	0.7	0.3	-0.7	2.4	-1.0
Hair/balding pattern: Pattern 2	0.5	0.6	2.7	0.9	0.0	0.2	1.7	-0.2	-0.5
Had menopause	0.4	0.5	1.1	0.4	0.9	-0.6	-1.1	0.1	0.8
Had other major operations	2.5	3.1	10.3	3.2	1.1	-1.4	-0.8	-1.3	1.5
Forced vital capacity (FVC)	0.8	3.1	9.4	0.5	-0.5	-0.9	-3.1	2.8	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	3.1	1.0	-0.3	-0.9	-1.8	-0.0	0.0
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	4.2	0.1	0.2	0.1	0.7	-2.1	1.2
Qualifications: None of the above	0.3	0.6	2.6	0.0	0.8	-0.4	-0.1	-1.6	0.4
Financial difficulties in last 2 years	1.4	1.9	6.6	-0.0	1.4	0.1	-1.1	1.2	2.6
Mouth/teeth dental problems	0.7	1.1	3.2	-0.7	-1.8	0.2	0.7	1.2	-0.8
Heart attack	0.4	0.5	1.9	0.1	0.7	-0.3	-1.4	0.7	0.6
Allergy	0.8	1.9	6.2	-0.5	2.5	0.2	0.5	-2.1	0.6
Pain all over the body in last month	0.4	0.4	2.4	-0.2	0.1	-0.0	1.5	-0.3	0.1
Diabetes (self-reported)	1.2	1.9	3.7	1.3	1.9	1.2	1.8	-1.0	0.5
Hayfever/allergic rhinitis (self-reported)	1.5	1.9	4.8	-1.2	-1.0	-0.6	-1.2	2.2	-1.6
Medication: Ramipril	0.4	0.5	2.0	1.4	0.3	0.2	0.3	0.5	0.7
Medication: Simvastatin	0.9	1.3	3.5	-1.0	1.9	1.7	-0.3	0.1	0.2
Fluid intelligence score	0.4	0.7	3.2	-0.1	-0.1	1.8	0.8	0.4	-0.7
Illnesses of siblings	1.7	2.4	5.7	0.8	-0.1	-1.6	1.2	-1.9	2.4
Neuroticism score	0.3	0.5	1.7	-0.7	0.3	-0.8	0.2	-1.3	0.5
Weight	0.3	1.4	5.7	-0.2	-0.9	-1.1	-2.4	0.6	-0.5
Impedance of arm (right)	2.0	9.3	30.8	0.2	1.8	2.6	5.5	-3.1	2.3
Arm fat percentage (right)	0.2	0.7	2.0	-0.8	-1.1	-0.6	-0.5	-1.4	-0.0
Trunk fat-free mass	0.7	4.2	14.0	-0.1	-1.5	-1.4	-3.7	2.5	-1.0
Hip circumference	0.2	0.8	2.1	0.2	-0.7	-1.5	-1.2	-0.7	-0.0
Time employed in main current job	0.5	0.6	2.3	0.5	0.5	1.5	-0.0	0.5	-0.8
Alcohol intake versus 10 years previously	1.5	2.3	6.0	2.5	0.1	-1.1	-0.4	-1.2	2.2
Father’s age at death	2.1	2.8	6.1	0.9	1.7	1.2	2.5	-1.6	1.6
Worrier / anxious feelings	0.7	1.3	2.8	-1.5	-1.7	-1.5	-0.5	-0.5	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	-0.1	0.2	-1.0	0.5	-0.9	0.0
Falls in the last year	1.1	1.5	3.9	1.8	-0.5	-2.0	0.5	-0.4	1.1
Hair/balding pattern: Pattern 3	1.5	2.2	5.0	-1.4	0.9	1.9	1.2	-2.2	0.1
Number of live births	0.8	1.2	3.0	1.5	0.8	-1.0	-0.2	-0.5	1.7
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	5.7	0.9	-0.7	-1.9	-2.4	2.1	0.2
Pulse rate	0.1	0.2	0.9	0.3	0.1	0.3	-0.4	-0.1	-1.0
Happiness	0.6	0.7	1.9	0.2	-1.3	-1.4	-0.6	0.7	0.2
Noisy workplace	0.7	0.8	2.7	-0.2	-0.4	-1.6	-1.1	-0.9	-0.2
Qualifications: A levels/AS levels or equivalent	0.4	1.0	4.7	-0.1	-0.5	-0.2	2.2	-0.7	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	3.9	-0.1	-0.4	-0.2	2.0	-0.2	0.8
Mouth/teeth dental problems: Dentures	1.0	1.7	4.4	1.0	1.8	-0.0	0.6	-2.1	1.2
Asthma	1.1	2.2	5.8	0.2	-2.1	-1.0	-1.2	2.4	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.0	-0.2	-1.2	-0.3	-0.9	-1.4	0.0
Medication: Cholesterol lowering	0.4	0.7	3.0	-0.1	0.8	0.1	-1.7	0.6	0.4
Depression (self-reported)	0.1	0.2	0.4	0.3	-0.4	0.5	0.4	0.0	-0.6
Medication: Lansoprazole	0.5	0.6	1.8	0.2	1.3	-0.1	1.0	0.0	0.9
Prospective memory result	0.1	0.1	0.4	0.1	0.7	0.4	0.1	0.2	0.0
Lung cancer (father)	0.8	0.9	1.7	-0.4	1.1	0.3	1.3	-1.0	1.3
Illnesses of mother	0.9	1.1	3.3	-0.9	-0.3	-1.2	-0.9	0.2	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.5	0.4	0.2	-0.6	-1.2	0.2	0.4
Pulse wave Arterial Stiffness index	0.7	0.8	2.5	-0.2	0.4	1.4	-0.0	0.3	-1.6
Impedance of arm (left)	2.5	11.4	40.4	0.1	2.0	2.6	6.4	-3.3	2.5
Arm fat mass (right)	0.2	1.0	2.7	-0.8	-1.2	-0.9	-1.6	-0.1	-0.4
Trunk predicted mass	0.8	4.3	14.1	-0.2	-1.5	-1.4	-3.8	2.5	-1.0
Standing height	0.1	0.9	1.9	0.7	1.4	0.7	0.9	1.2	0.8
Length of working week for main job	0.6	0.7	1.5	1.1	0.8	-1.2	-0.6	0.5	0.4
Exposure to tobacco smoke at home	1.6	1.8	4.8	1.4	1.1	-0.7	1.4	-2.2	0.5
Breastfed as a baby	1.9	2.3	3.5	-1.9	-1.4	-0.8	-1.3	1.9	-1.6
Tense / ‘highly strung’	0.3	0.5	1.6	-1.3	0.1	-0.0	0.6	-1.0	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.5	1.4	-0.5	0.5	-0.9	-0.0	-1.2	0.7
Hair/balding pattern: Pattern 4	0.7	1.6	5.2	-2.3	-0.8	0.4	-0.7	-0.6	-1.7
Birth weight of first child	1.1	2.0	6.1	0.9	-0.1	-0.5	-2.5	1.6	-1.5
Peak expiratory flow (PEF)	0.8	1.8	4.7	1.4	-0.9	-1.3	-2.2	1.3	0.2
Pulse wave reflection index	0.4	0.5	1.0	0.4	-0.1	1.0	0.7	0.8	-0.8
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.1	0.4	0.6	-0.0	-0.7	0.6
Loud music exposure frequency	0.2	0.2	1.3	0.3	-0.1	0.1	-0.1	-0.2	1.2
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	5.0	0.8	-0.9	-0.5	2.2	-1.9	-0.1
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	4.3	-0.8	0.3	-0.7	-2.1	0.4	-0.3
Blood clot in the leg (DVT)	0.9	1.2	2.7	-0.5	-1.2	-1.3	-1.6	0.6	-0.7
Medication: Paracetamol	0.4	0.7	1.9	1.4	0.3	-0.5	-1.1	0.3	0.7
Headache pain in last month	2.1	3.6	11.1	2.6	3.3	-0.2	-0.7	-1.2	1.4
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.9	1.7	-0.9	-1.2	0.0	0.8	-0.3
Glaucoma (self-reported)	0.4	0.5	2.6	-0.5	-0.2	0.5	1.6	0.0	-0.1
Gout (self-reported)	0.9	1.2	2.8	1.4	0.7	-0.5	1.7	0.9	1.1
Hypothyroidism/myxoedema (self-reported)	1.4	2.6	7.4	0.2	0.7	-2.2	0.6	-2.7	1.6
Medication: Amlodipine	0.7	1.0	2.3	0.3	0.3	0.2	1.5	-1.3	1.3
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.7	1.1	-0.3	1.3	0.5	0.0	1.0
Birth weight	2.7	5.9	20.8	0.1	-2.0	-0.9	-3.1	4.6	0.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.3	-0.3	0.3	-0.9	0.0	-1.1	-1.1
High blood pressure (siblings)	2.0	2.9	5.2	-1.6	-0.6	1.2	-1.8	2.2	-2.3
Forced vital capacity (FVC), Best measure	0.3	1.0	4.2	-0.0	0.2	0.2	-2.0	1.2	-0.3
Body fat percentage	0.1	0.6	2.3	-0.2	0.0	-0.2	0.7	-1.5	0.7
Leg fat percentage (right)	0.0	0.1	0.3	-0.2	-0.0	-0.2	-0.3	-0.6	0.1
Arm fat-free mass (right)	0.6	3.0	10.7	0.1	-0.7	-1.4	-3.3	2.0	-0.8
Exposure to tobacco smoke outside home	1.3	1.7	5.2	1.1	-0.0	-1.7	0.3	-2.3	1.1
Comparative body size at age 10	0.8	2.1	6.9	-0.1	-1.1	-2.6	-1.8	1.1	-0.1
Number of full brothers	1.7	2.1	4.2	1.2	2.0	0.8	0.9	-1.9	1.5
Worry too long after embarrassment	0.8	1.4	6.2	-2.5	-0.3	-0.2	-0.1	-0.1	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	-0.7	-0.1	-0.5	1.0	0.0	0.7
Wheeze or whistling in the chest in last year	1.0	1.8	5.0	1.7	0.1	-1.6	-0.4	-0.0	2.2
Number of children fathered	2.3	2.6	7.0	1.7	2.6	-1.2	0.4	-0.5	2.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	4.5	-2.1	-0.8	0.8	0.1	-0.5	0.2
Age at first live birth	1.0	1.8	6.9	-2.6	-1.4	0.7	-0.5	0.8	-0.5
Pulse wave peak to peak time	0.9	1.0	3.4	0.1	-0.4	-1.5	-0.0	-0.2	1.8
Health satisfaction	0.6	0.8	1.7	-0.0	-0.1	-1.3	-0.1	-1.2	1.3
Shortness of breath walking on level ground	0.3	0.4	1.3	-1.2	0.4	0.7	0.5	-0.3	0.2
Qualifications: College or University degree	0.1	0.4	1.4	-1.0	-1.2	0.0	0.0	0.3	-0.1
Eye problems/disorders: None of the above	0.5	0.6	1.1	-0.6	-1.0	-0.6	-1.1	0.6	-0.6
Mouth/teeth dental problems: Loose teeth	2.9	3.5	8.8	0.6	1.1	-1.0	1.8	-3.0	2.5
Emphysema/chronic bronchitis	1.5	1.7	3.8	1.3	1.6	0.3	1.9	-0.6	1.4
Medication for pain relief, constipation, heartburn	0.7	1.2	6.4	0.1	0.5	0.5	2.5	-0.6	0.4
Neck or shoulder pain in last month	0.4	0.6	2.0	1.1	0.4	-0.4	-0.4	-0.4	1.4
Medication: Blood pressure	0.7	1.2	3.6	-1.9	0.5	0.7	0.9	-1.5	0.2
Angina (self-reported)	0.3	0.4	0.8	0.8	0.2	0.1	-0.9	0.7	-0.3
Migraine (self-reported)	1.3	1.7	5.1	2.3	1.7	0.1	0.9	-0.8	0.8
Medication: Ibuprofen	0.6	0.7	2.5	-0.4	-1.6	0.1	-0.7	-1.0	-0.1
Medication: Allopurinol	0.9	1.2	3.2	0.2	1.7	0.2	1.8	-0.4	1.0
Medication: Omeprazole	0.8	1.0	2.6	-1.0	-0.6	0.4	-0.6	1.6	-1.2
Medication: Seretide 50 evohaler	0.5	0.5	2.9	0.1	-0.3	0.3	-0.3	1.7	0.0
Mean time to correctly identify matches	2.4	4.6	14.5	0.9	-1.7	-1.9	-3.8	2.3	-0.7
Heart disease (mother)	0.7	0.8	2.7	-0.1	0.2	0.5	-1.4	-0.3	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	3.4	1.5	1.0	-0.7	1.1	-1.0	1.9
Whole body fat mass	0.0	0.2	0.4	-0.5	-0.4	-0.3	-0.4	-0.6	0.0
Leg fat mass (right)	0.1	0.4	1.1	-0.5	-0.6	-0.5	-1.1	-0.4	-0.2
Arm predicted mass (right)	0.5	2.5	8.7	0.2	-0.7	-1.2	-2.9	1.9	-0.8
Pulse rate, automated reading	0.5	1.7	5.6	0.5	0.7	2.4	1.8	-0.8	0.1
Alcohol intake frequency.	0.6	1.5	3.5	0.7	-0.1	-1.9	-1.6	-0.5	1.4
Comparative height size at age 10	0.2	0.9	3.9	0.1	1.1	0.4	-0.0	2.0	0.5
Number of full sisters	0.6	0.7	3.0	1.7	-0.4	-0.9	-0.7	0.2	0.0
Suffer from ‘nerves’	1.0	1.5	4.5	-0.7	0.7	0.4	1.8	-2.1	0.6
Overall health rating	0.1	0.2	0.7	-0.1	-0.4	-0.8	-0.2	0.0	0.5
Chest pain or discomfort	1.1	1.6	3.4	1.7	1.3	-0.7	0.3	-1.8	0.9
Had major operations	0.7	0.8	1.3	1.0	1.1	0.7	1.1	0.2	0.9
Age at last live birth	0.2	0.2	0.5	-0.6	-0.7	-0.1	-0.1	-0.2	0.6
Family relationship satisfaction	0.2	0.3	1.0	-0.1	-0.7	-0.5	0.1	1.0	0.4
Leg pain on walking	0.5	0.6	1.6	1.3	-0.1	0.1	1.1	-0.6	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.7	3.6	1.9	-0.4	0.1	-0.1	-0.1	0.4
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.7	1.5	0.0	-1.9	-0.0	1.1	1.7
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	4.0	0.9	-1.8	-1.0	-1.6	2.0	-1.6
Medication: Aspirin	0.2	0.3	0.6	0.1	0.7	0.5	-0.8	0.4	0.5
Supplements: Vitamin C	0.9	1.1	2.4	1.6	-0.2	-0.6	-1.0	1.0	1.4
Knee pain experienced in last month	0.3	0.4	1.4	-0.2	1.0	-0.3	1.2	-0.3	0.3
Hypertension (Self-reported)	0.3	0.9	2.2	-1.5	0.6	-0.1	0.9	-1.3	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	3.2	1.0	0.1	1.8	0.5	0.8	-1.2
Illnesses of father: Heart disease	1.9	2.7	7.9	0.1	-0.5	1.2	-2.8	2.2	-1.3
Illnesses of siblings: Diabetes	0.6	0.7	2.6	0.6	0.6	0.8	-0.6	1.6	-0.3
Smoking status: Previous	0.6	0.9	2.4	-0.4	-0.0	-1.6	-0.6	-1.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	2.0	0.7	0.2	1.4	-0.5	0.3	0.5
Whole body fat-free mass	0.7	3.8	13.6	-0.4	-1.6	-1.2	-3.7	1.9	-1.3
Leg fat-free mass (right)	0.4	2.3	8.6	-0.6	-1.8	-0.9	-2.9	0.5	-1.0
Arm fat percentage (left)	0.2	0.7	2.5	-0.8	-1.0	-0.4	0.1	-1.6	0.1
Average weekly red wine intake	1.8	2.6	6.5	1.3	1.1	-2.6	1.5	-1.5	1.4
Handedness (chirality/laterality): Left-handed	1.8	2.1	4.5	-1.1	-2.1	0.1	-1.7	1.9	-0.7
Mood swings	0.7	1.2	4.7	1.1	0.8	-0.7	0.1	-2.2	0.3
Loneliness, isolation	0.3	0.4	1.2	-0.0	-0.7	-0.6	0.1	-0.0	1.1
Long-standing illness, disability or infirmity	0.1	0.2	0.3	0.2	0.1	-0.0	0.5	0.6	0.5
Ever had bowel cancer screening	0.8	1.0	1.9	0.9	1.4	0.3	1.3	0.9	0.7
Diabetes diagnosed by doctor	0.9	1.5	2.3	1.5	1.4	1.4	1.5	-0.4	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.1	-0.7	-0.0	-0.1	0.8	-1.0	0.6
Friendships satisfaction	1.1	1.3	3.4	-0.7	-1.8	-1.6	-0.7	0.0	-1.0
Qualifications: nursing, teaching	1.4	2.2	5.3	-2.3	-1.6	-0.1	0.2	0.3	-2.3
Commuting to job workplace: Walk	0.8	0.9	2.2	-0.4	0.5	1.5	1.3	-0.5	0.8
Eye problems/disorders: Cataract	1.2	1.3	3.4	-0.2	0.6	-0.3	1.5	-1.8	1.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.9	0.9	0.4	-0.1	-0.5	1.7	-0.3
Medication for cholesterol	0.1	0.2	0.4	0.3	0.1	0.5	0.5	-0.5	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.0	-0.1	-0.2	1.0	0.4	-0.3	0.1
Back pain experienced in last month	0.8	1.1	3.1	1.1	0.5	-1.8	-0.1	0.5	1.4
Mineral and other dietary supplements	0.4	0.5	1.1	0.8	-0.7	1.1	0.8	0.3	-0.4
Breast cancer (self-reported)	1.1	1.4	4.8	0.3	-0.5	-0.0	1.8	-2.2	0.0
Asthma (self-reported)	1.2	2.3	5.3	0.0	-2.1	-1.2	-1.5	2.3	-0.8
Osteoporosis (self-reported)	1.4	1.7	4.6	-1.0	0.5	-0.4	1.8	-1.0	2.1
Osteoarthritis (self-reported)	0.4	0.5	1.4	1.2	-0.1	-0.6	0.1	0.9	0.8
Medication: Aspirin	0.4	0.5	1.3	0.4	1.2	0.4	-0.9	0.6	0.5
Medication: Gliclazide	1.2	1.4	4.2	0.8	0.3	0.5	2.0	-1.4	1.0
Illnesses of father: None of the above (group 1)	1.3	1.5	2.8	-1.5	0.0	-0.9	1.7	-1.4	1.2
Smoking status: Current	2.1	3.3	8.0	-0.8	2.2	2.8	2.0	-0.7	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	1.0	0.0	-0.4	-1.0	-0.8	-0.1	-0.5
Whole body water mass	0.7	3.9	13.9	-0.5	-1.7	-1.2	-3.7	1.9	-1.3
Leg predicted mass (right)	0.4	2.3	8.5	-0.5	-1.8	-0.9	-2.9	0.5	-1.0
Arm fat mass (left)	0.2	1.0	2.5	-0.8	-1.3	-0.8	-1.6	-0.1	-0.6
Number of self-reported non-cancer illnesses	0.2	0.4	1.0	-0.3	-0.9	-0.3	-0.5	1.0	-0.2
Average weekly champagne plus white wine intake	0.1	0.2	0.6	-0.0	0.4	0.4	0.4	-0.3	-0.8
Miserableness	0.4	0.7	2.4	-0.9	-0.1	-0.8	-0.1	-1.5	0.5
Guilty feelings	0.3	0.5	1.4	-0.5	0.1	-0.8	-1.2	0.7	-0.1
Wears glasses or contact lenses	1.7	1.9	3.9	-0.4	1.7	0.4	2.0	-0.9	1.9
Ever taken oral contraceptive pill	0.7	0.8	3.9	0.4	0.5	2.0	-0.5	0.0	0.1
Hearing aid user	0.7	0.8	1.5	-0.8	-1.2	0.1	-0.0	1.1	-1.0
Mother’s age at death	0.3	0.3	0.6	0.6	-0.6	0.7	-0.4	0.2	-0.8
Financial situation satisfaction	1.3	1.7	5.2	0.1	1.4	0.7	0.9	-1.3	2.3
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.0	1.0	0.1	-0.0	-0.8	0.2	0.7
Commuting to job workplace: Public transport	1.1	1.3	3.4	-1.8	-0.8	0.9	0.2	0.4	-1.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	-0.3	-0.7	-0.1	0.8	0.1	0.4
Medication: Blood pressure	0.2	0.4	1.1	-0.1	-0.1	-1.1	-0.7	0.6	0.3
Pain type(s) experienced in last month: Hip pain	1.2	1.5	5.1	1.8	2.3	-0.3	-0.1	0.2	0.8
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.5	-0.7	1.2	-0.9	0.1	-1.2	0.7
High cholesterol (Self-reported)	1.0	1.7	5.7	-2.4	1.0	-1.2	-1.4	0.4	0.1
Medication: Bendroflumethiazide	0.3	0.5	1.4	-0.6	-0.4	-0.0	0.8	-0.5	-1.2
Medication: Paracetamol	0.6	0.9	2.8	1.7	0.3	-0.1	-0.8	0.9	1.1
Medication: Lisinopril	0.7	0.9	3.1	-1.3	0.3	1.8	0.6	-0.4	-0.1
Medication: Atorvastatin	1.5	1.9	5.2	1.2	0.5	-2.3	0.0	-0.9	1.9
Illnesses of father: High blood pressure	0.3	0.4	1.4	0.2	0.5	0.2	-0.8	-1.2	-0.4
Alcohol drinker status: Never	0.3	0.3	1.3	-0.4	-0.6	-1.1	-0.1	0.3	-0.3
Ever smoked	0.5	0.9	2.4	0.1	1.6	-0.8	0.0	-1.5	0.4
Basal metabolic rate	0.6	3.3	12.0	-0.5	-1.5	-1.3	-3.5	1.5	-1.1
Leg fat percentage (left)	0.1	0.2	0.6	0.3	0.2	-0.3	-0.2	-0.8	0.5
Arm fat-free mass (left)	1.0	5.1	18.2	-0.4	-1.3	-1.7	-4.3	2.4	-1.4
Number of operations (self-reported)	1.5	2.2	8.6	2.9	1.2	-0.6	0.3	-0.8	1.6
Average weekly beer plus cider intake	0.4	0.6	2.2	-0.4	-0.8	0.5	1.5	-0.8	0.3
Irritability	0.8	1.4	3.4	-0.5	1.9	-0.6	1.2	-1.1	1.3
Risk taking	1.0	1.4	5.4	2.3	0.7	0.4	0.7	0.5	1.3
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.8	-0.6	-0.9	1.6	1.7	1.3	-1.0
Fractured/broken bones in last 5 years	0.8	1.0	3.5	-1.9	-1.2	-0.3	-0.6	0.2	-0.6
Age started oral contraceptive pill	0.4	0.5	1.5	0.6	-0.6	-1.2	-0.2	0.0	-0.8
Diastolic blood pressure, automated reading	0.6	1.8	3.5	-1.3	1.2	1.0	1.9	-1.6	-1.0
Ever depressed for a whole week	0.2	0.3	0.8	-0.2	0.2	0.9	0.1	0.1	-0.8
Unable to work because of sickness or disability	0.2	0.2	0.5	0.0	0.6	-0.1	0.7	0.1	0.7
Commuting to job workplace: Cycle	1.0	1.2	3.1	-0.2	-1.8	-0.4	-0.7	1.3	-1.2
Myopia	1.2	1.7	3.4	-1.6	-1.1	1.9	0.2	0.5	-1.7
Vascular/heart problems diagnosed by doctor	0.4	1.1	4.0	2.0	-1.0	-0.2	-0.6	1.0	0.3
Cholesterol lowering medication	1.0	1.5	4.4	0.2	2.1	-1.0	-0.3	-0.6	1.7
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.6	-1.0	-0.8	0.3	-0.5	1.6	-1.6
Pain experienced in last month	1.0	1.7	4.5	-1.7	-2.1	0.6	0.2	-0.1	-1.6
Supplements: Calcium	1.4	1.6	3.9	-0.2	2.0	0.9	-1.5	1.4	0.5
Basal cell carcinoma (self-reported)	1.3	1.6	2.7	-0.0	1.4	-1.6	-0.6	1.4	1.6
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.1	0.0	0.6	-0.1	-1.4	0.9	0.5
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	3.9	-0.4	-1.3	-1.3	-2.0	0.9	-0.9
Heart disease (siblings)	0.5	0.7	1.6	-1.1	0.2	-0.5	-0.6	-1.3	-0.6
Alcohol drinker status: Previous	1.2	1.3	2.9	0.5	0.7	0.6	1.0	-1.7	1.7
Pack years of smoking	1.1	1.6	3.2	1.6	0.7	1.0	1.2	-1.8	1.1
Impedance of whole body	2.2	11.3	38.9	0.7	2.8	2.3	6.2	-2.9	2.6
Leg fat mass (left)	0.1	0.4	1.3	-0.3	-0.7	-0.7	-1.1	-0.4	-0.1
Arm predicted mass (left)	0.8	4.2	15.6	-0.1	-1.0	-1.9	-3.9	2.0	-1.0