TWAS hub - RNF185

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0910	0.0260	2.9e-10	0.046	0.079	0.086	0.079	0.080	2.8e-06	6.7e-10	1.3e-10	7.3e-10	5.1e-10
2	GTEx	Skin Not Sun Exposed Suprapubic	0.1500	0.0630	4.6e-03	0.010	NA	0.017	NA	0.012	9.1e-02	NA	4.0e-02	NA	6.6e-02
3	GTEx	Thyroid	0.0480	0.0220	2.0e-03	0.031	NA	0.015	NA	0.025	1.8e-03	NA	2.4e-02	NA	5.1e-03
4	METSIM	Adipose	0.0982	0.0316	1.1e-08	0.071	0.054	0.055	0.061	0.066	7.2e-11	1.5e-08	1.3e-08	1.8e-09	3.3e-10
5	NTR	Blood	0.0340	0.0115	1.3e-06	0.029	0.021	0.035	0.029	0.035	8.5e-10	1.6e-07	2.2e-11	7.4e-10	2.2e-11
6	YFS	Blood	0.0372	0.0121	6.8e-09	0.032	0.022	0.026	0.023	0.027	8.5e-11	6.1e-08	6.1e-09	3.9e-08	2.8e-09
7	TCGA	Breast Invasive Carcinoma	0.0130	0.0072	3.1e-03	0.013	0.011	0.008	NA	0.010	1.0e-03	2.1e-03	7.1e-03	NA	2.7e-03
8	TCGA	Colon Adenocarcinoma	0.0850	0.0360	4.1e-05	0.051	0.082	0.056	NA	0.066	6.5e-04	1.9e-05	3.6e-04	NA	1.1e-04
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0515	0.0254	4.1e-05	0.023	0.038	0.038	NA	0.023	1.1e-03	4.0e-05	3.7e-05	NA	1.2e-03
10	TCGA	Prostate Adenocarcinoma	0.0625	0.0278	1.0e-05	0.047	0.051	0.045	NA	0.034	9.8e-06	4.6e-06	1.5e-05	NA	1.5e-04
11	TCGA	Rectum Adenocarcinoma	0.1840	0.1010	6.4e-03	0.104	0.073	0.120	NA	0.108	2.0e-03	8.8e-03	9.7e-04	NA	1.7e-03
12	TCGA	Thyroid Carcinoma	0.0610	0.0260	2.3e-06	0.085	0.059	0.065	NA	0.072	1.2e-08	2.2e-06	5.8e-07	NA	1.5e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Reaction Time	7.0	13.3	23.9	-1.6	0.0	3.7	4.3	1.0	3.2	4.5	4.9	4.0	4.0	4.5	4.0
Mean time to correctly identify matches	6.3	11.9	21.3	-1.6	-0.0	3.6	4.1	0.5	3.0	4.0	4.6	3.6	4.0	4.5	3.9
Blood Eosinophil Count	5.3	40.8	132.2	-11.5	3.3	11.0	4.2	-0.1	9.2	0.9	2.7	0.6	5.3	7.0	6.1
Age when periods started (menarche)	5.3	12.7	23.4	1.4	1.1	-4.0	-3.9	1.3	-2.9	-3.4	-4.3	-3.9	-4.5	-4.5	-4.8
Waist Hip Ratio (WHR)	4.5	20.2	39.3	2.8	-3.6	-4.3	-6.0	-4.6	-6.3	-4.6	-4.7	-3.9	-2.3	-4.7	-4.7
Bipolar Disorder or Schizophrenia	4.3	10.4	22.3	-1.5	1.2	2.1	4.7	3.1	3.7	4.6	3.9	3.7	1.5	3.0	3.1
Impedance of arm (left)	4.2	19.3	38.4	1.3	1.5	-4.6	-4.7	1.8	-3.0	-4.5	-5.4	-4.8	-5.2	-5.7	-6.2
Severe depression (siblings)	4.1	4.6	12.9	-3.5	1.8	3.6	1.7	-0.1	3.3	0.1	0.7	0.2	1.4	2.3	2.3
Current tobacco smoking	3.9	6.4	10.9	2.3	-1.5	-3.0	-2.9	-1.0	-2.7	-2.6	-2.9	-2.2	-2.3	-3.3	-2.8
Impedance of whole body	3.9	20.0	38.3	1.9	0.7	-5.1	-5.0	0.8	-3.9	-4.5	-5.4	-4.5	-5.2	-5.9	-6.2
Impedance of arm (right)	3.8	17.6	35.6	1.5	1.1	-4.4	-4.6	1.8	-3.0	-4.1	-5.1	-4.5	-5.2	-5.6	-6.0
Number of live births	3.7	5.3	13.8	1.3	-0.8	0.5	2.5	0.0	0.5	3.7	3.4	3.6	2.7	2.1	2.2
Impedance of leg (left)	3.6	17.6	31.4	2.3	-1.0	-4.9	-4.9	-0.9	-4.7	-4.1	-4.9	-3.8	-4.2	-5.4	-5.6
Had other major operations	3.6	4.4	11.4	-0.2	0.0	1.2	3.4	2.0	1.9	2.8	2.5	2.6	0.4	2.0	2.6
Verbal and Numeric Reasoning (VNR)	3.5	8.5	13.2	2.2	-2.7	-2.4	-3.6	-2.7	-3.6	-3.6	-3.1	-3.3	-1.3	-2.6	-3.0
Impedance of leg (right)	3.5	16.8	29.1	2.1	-0.9	-4.6	-4.8	-0.7	-4.3	-4.3	-4.9	-3.8	-4.2	-5.4	-5.4
Ever had prostate specific antigen (PSA) test	3.3	3.8	7.8	-0.2	-1.1	-1.0	-2.6	-1.8	-2.0	-2.5	-2.5	-2.8	-0.8	-1.8	-2.3
Birth weight of first child	3.2	5.8	9.8	-2.8	2.3	3.1	2.3	-0.3	2.8	1.3	2.1	1.4	2.6	3.1	3.0
Exposure to tobacco smoke outside home	3.2	4.2	12.9	0.1	2.4	0.6	2.6	3.6	2.4	2.7	1.9	2.4	-0.3	0.8	1.3
Medication for pain relief, constipation, heartburn	3.2	5.4	12.2	1.1	0.3	-2.5	-3.2	0.4	-2.0	-2.3	-2.5	-2.4	-2.1	-3.0	-3.5
Schizophrenia (2018)	3.1	6.5	13.4	-2.0	0.6	2.2	3.7	2.1	3.1	3.5	2.8	2.9	1.1	2.4	2.5
Pain all over the body in last month	3.1	3.4	6.7	0.1	0.1	-1.5	-2.3	-1.3	-1.7	-2.6	-2.5	-2.3	-1.5	-1.8	-2.1
Noisy workplace	3.1	3.8	8.9	-2.4	1.8	2.6	2.3	1.0	3.0	1.2	1.5	1.1	1.5	1.8	2.0
Smoking status: Current	3.1	5.0	7.9	1.6	-1.3	-2.5	-2.6	-1.1	-2.4	-2.5	-2.7	-2.1	-2.0	-2.8	-2.3
Alcohol usually taken with meals	3.0	4.8	10.5	0.9	-0.9	1.3	2.8	-0.1	1.0	2.9	3.2	2.6	2.8	2.5	2.4
Father’s age at death	3.0	4.1	8.4	2.2	0.1	-2.8	-0.8	2.2	-1.4	-0.8	-1.5	-1.7	-2.9	-2.6	-2.8
Schizophrenia (2014)	2.9	6.4	13.1	-1.7	0.3	1.7	3.4	1.6	2.9	3.6	3.0	3.2	1.7	2.6	2.7
Alcohol intake versus 10 years previously	2.9	4.3	8.3	-1.5	-0.0	1.9	2.6	0.4	2.1	2.1	2.5	2.6	1.6	2.4	2.9
Blood White Count	2.8	21.0	53.3	5.9	-1.5	-7.3	-4.5	1.7	-5.3	-1.7	-3.3	-1.3	-4.6	-6.2	-6.0
Medication: Lansoprazole	2.8	3.2	7.5	0.3	-1.1	-1.8	-2.7	-1.6	-2.3	-2.2	-1.9	-1.6	-0.4	-1.7	-2.0
Peak expiratory flow (PEF)	2.8	6.5	16.6	-1.8	-2.1	2.8	2.0	-2.5	0.9	2.0	2.6	1.8	4.1	3.6	2.9
Forced expiratory volume in 1-second (FEV1)	2.7	9.0	20.8	-2.1	-2.5	3.2	2.7	-2.3	1.3	2.6	3.2	2.3	4.6	4.1	3.6
Bipolar Disorder (2018)	2.6	4.2	9.0	0.0	1.1	0.7	3.0	2.3	2.1	3.0	2.6	2.3	1.0	1.9	1.9
Alzheimer’s Disease (in father)	2.6	2.8	10.7	-3.3	-0.3	2.5	0.6	-1.3	1.4	-0.1	0.7	0.3	1.8	2.2	1.8
Fasting Glucose	2.6	3.1	7.4	0.1	0.3	-2.0	-2.2	0.1	-1.3	-2.2	-2.0	-2.7	-1.3	-1.7	-2.4
Glaucoma (self-reported)	2.6	3.1	6.0	1.7	0.1	-1.8	-1.7	-0.8	-2.0	-1.6	-2.0	-1.3	-2.2	-2.5	-1.9
Pulse wave peak to peak time	2.5	2.9	5.6	-0.1	-1.3	1.1	2.3	-0.0	0.9	2.4	2.3	2.0	1.8	2.1	1.9
Ever had bowel cancer screening	2.5	3.0	6.1	0.9	-0.8	-2.0	-2.1	-1.1	-2.5	-1.8	-1.6	-1.8	-0.7	-1.8	-2.4
Suffer from ‘nerves’	2.4	3.7	7.1	0.1	0.7	-1.5	-2.2	0.7	-0.9	-2.5	-2.7	-2.4	-2.6	-2.3	-2.2
Intelligence (Savage-Jansen 2018)	2.3	7.2	14.5	1.2	-2.1	-1.9	-3.1	-2.4	-2.9	-3.7	-3.2	-3.8	-1.3	-2.3	-2.8
Arm fat-free mass (left)	2.3	11.6	23.2	-1.9	-1.6	3.8	3.3	-2.3	2.1	2.9	3.8	3.0	4.8	4.8	4.5
Chronotype (morning person)	2.2	5.0	12.4	2.2	-1.3	0.3	2.5	0.3	0.2	3.5	3.3	3.3	2.3	2.0	2.0
Hair/balding pattern: Pattern 2	2.2	2.7	4.8	1.7	-1.0	-2.0	-1.7	-1.3	-2.2	-1.7	-1.8	-1.1	-1.5	-1.9	-1.4
Arm predicted mass (left)	2.2	11.1	21.8	-1.7	-1.5	3.7	3.3	-2.1	2.1	2.9	3.8	3.0	4.6	4.7	4.5
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.7	7.9	-0.2	0.2	2.5	2.8	0.9	2.2	2.4	2.8	2.3	2.0	2.5	2.7
Trunk fat-free mass	2.1	11.9	24.7	-1.8	-2.1	3.8	3.3	-2.3	2.0	2.9	3.9	2.9	5.0	4.9	4.5
Trunk predicted mass	2.1	12.1	24.7	-1.8	-2.2	3.8	3.3	-2.3	2.0	2.9	3.9	2.9	5.0	4.9	4.5
Fed-up feelings	2.0	3.7	6.3	-0.7	0.1	1.6	2.4	0.9	2.1	2.5	2.3	2.4	1.3	2.1	2.5
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	6.1	-2.0	1.1	0.7	-1.6	-0.8	0.2	-2.5	-2.2	-2.2	-1.3	-0.9	-0.6
Forced vital capacity (FVC)	2.0	7.5	15.2	-2.8	-2.5	3.4	2.0	-2.5	1.3	1.6	2.4	1.6	3.9	3.9	3.4
Health satisfaction	2.0	2.6	4.9	0.1	-1.5	0.9	2.1	-0.1	1.1	1.8	2.0	2.0	1.7	1.8	2.2
Supplements: Vitamin C	2.0	2.3	5.2	1.2	-1.5	0.3	1.5	-0.7	-0.5	1.9	2.3	2.1	1.9	1.6	1.4
Hearing difficulty/problems: Yes	1.9	2.8	7.8	0.2	-0.1	-1.2	-2.8	-2.0	-1.8	-2.3	-2.1	-1.7	-0.6	-1.5	-1.7
Happiness	1.9	2.3	5.7	0.8	-1.0	0.6	1.5	-0.9	0.1	1.8	2.0	2.4	1.8	1.7	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.1	11.9	-2.2	-1.2	2.8	2.6	-0.9	1.9	2.3	2.6	1.8	3.4	3.5	3.1
Hypothyroidism/myxoedema (self-reported)	1.9	3.7	9.9	-1.2	0.1	1.5	2.1	-0.5	2.1	1.6	2.0	2.4	1.7	2.4	3.2
Arm fat-free mass (right)	1.9	9.6	21.3	-1.7	-1.5	3.2	2.8	-2.7	1.5	2.4	3.3	2.7	4.6	4.4	4.2
Long-standing illness, disability or infirmity	1.9	2.8	10.9	0.1	-2.2	-1.2	-2.0	-3.3	-2.4	-1.5	-1.2	-1.0	0.9	-0.5	-0.8
Hypothyroidism (self reported)	1.8	4.1	9.5	-1.3	0.6	1.9	2.7	1.0	3.1	1.9	1.9	2.2	0.8	2.2	3.0
Hand grip strength (right)	1.8	4.9	11.1	-2.8	-1.7	2.9	1.6	-1.6	1.6	1.2	1.8	0.5	3.3	3.3	2.3
Hair/balding pattern: Pattern 3	1.8	2.6	5.6	-0.4	1.4	-0.9	-1.3	0.4	-0.0	-2.2	-2.3	-2.4	-2.3	-1.7	-1.6
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	6.7	-0.4	0.1	1.4	2.4	2.6	2.1	1.8	1.2	1.2	-0.6	0.8	1.2
Pulse wave Arterial Stiffness index	1.8	2.1	4.1	0.1	0.8	-0.9	-2.0	-0.1	-0.9	-2.0	-1.9	-1.7	-1.3	-1.7	-1.6
Length of working week for main job	1.8	2.0	6.7	0.3	0.0	0.7	1.5	1.0	1.3	2.1	1.6	2.6	0.2	1.0	1.9
Birth weight	1.8	3.8	9.6	-2.4	0.6	2.9	1.0	-1.5	1.7	0.7	1.6	0.7	3.1	2.8	2.1
Whole body fat-free mass	1.8	10.3	21.0	-1.9	-1.3	3.7	3.2	-1.8	2.2	2.7	3.6	2.6	4.5	4.6	4.3
Commuting to job workplace: Walk	1.8	2.0	6.6	2.6	-1.0	-2.1	-1.2	-0.8	-2.1	-0.8	-0.8	-0.7	-0.6	-1.2	-1.4
Whole body water mass	1.8	10.4	21.4	-2.0	-1.1	3.8	3.2	-1.8	2.3	2.7	3.5	2.6	4.5	4.6	4.3
Heel T-Score	1.7	13.2	24.7	0.4	-2.3	2.8	3.9	-0.9	1.6	4.5	5.0	4.5	4.7	4.4	4.5
Ever had hysterectomy (womb removed)	1.7	1.9	6.2	-2.5	1.4	1.6	1.3	1.0	2.3	0.5	0.5	0.5	0.1	1.0	1.5
Diabetes (father)	1.7	2.1	7.9	1.6	-2.8	-1.6	-1.5	-1.8	-2.0	-0.7	-0.6	-0.1	-0.4	-1.1	-0.9
Comparative body size at age 10	1.7	4.8	9.7	0.3	-0.5	1.1	2.9	0.3	1.4	2.8	3.1	2.6	2.3	2.8	3.0
Mother’s age at death	1.7	2.2	5.1	0.0	0.9	0.9	2.3	2.1	1.6	2.0	1.8	1.2	0.4	1.4	1.1
Basal metabolic rate	1.7	9.2	18.5	-1.8	-0.9	3.5	3.1	-1.5	2.2	2.7	3.4	2.6	4.2	4.3	4.0
Average weekly beer plus cider intake	1.7	2.5	4.5	0.1	1.4	-1.7	-2.1	-0.3	-1.5	-1.6	-2.1	-0.9	-1.8	-2.1	-1.6
Alzheimer’s Disease (in mother)	1.6	1.9	6.6	-0.8	0.2	-1.0	-2.6	-0.6	-0.8	-1.7	-1.7	-1.4	-0.7	-1.5	-1.7
Body Mass Index (BMI) (2010)	1.6	2.2	4.8	-1.2	0.2	1.6	1.5	-0.6	1.0	1.3	1.8	1.1	2.0	2.2	1.9
Coronary Artery Disease (CAD)	1.6	1.9	4.4	0.0	0.4	0.5	2.1	0.1	1.3	1.7	1.6	1.7	0.8	1.7	2.1
Hand grip strength (left)	1.6	4.3	8.8	-2.5	-1.7	2.8	1.4	-1.7	1.4	1.0	1.6	0.8	2.9	3.0	2.5
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	4.4	-2.1	2.0	1.4	-0.3	1.2	1.8	-1.1	-1.0	-1.0	-1.0	-0.7	-0.7
Hayfever, allergic rhinitis or eczema	1.6	3.5	13.6	-0.5	-3.2	0.4	-2.1	-3.7	-2.3	-0.9	-0.1	-0.6	2.4	0.5	-0.7
Mouth/teeth dental problems: Loose teeth	1.6	1.9	4.8	1.1	-0.3	-0.3	1.7	0.1	0.2	2.1	1.9	2.2	1.2	1.1	1.5
Arm predicted mass (right)	1.6	8.0	19.0	-1.5	-1.6	2.8	2.4	-2.9	1.1	2.0	2.9	2.3	4.4	4.0	3.8
Systolic Blood Pressure	1.5	7.6	13.5	1.8	0.7	-2.4	-2.4	0.8	-1.3	-3.1	-3.5	-3.6	-3.7	-3.7	-3.5
Serious illness, injury or assault to yourself	1.5	1.8	9.0	3.0	-0.6	-2.5	-0.2	0.6	-1.3	0.9	0.1	1.0	-1.0	-1.1	-0.3
Illnesses of siblings	1.5	2.1	3.9	-0.9	0.9	0.7	1.6	1.5	1.9	1.8	1.6	2.0	0.9	1.4	1.7
Breast cancer (self-reported)	1.5	1.8	5.9	1.0	2.4	-1.2	-0.1	2.4	0.2	0.5	-0.4	-0.1	-1.5	-1.5	-1.5
Tinnitus: Yes, now most or all of the time	1.5	1.7	3.5	0.3	-1.6	0.4	0.8	-0.6	-0.0	1.6	1.8	1.8	1.9	1.6	1.4
Age at First Birth	1.4	2.0	5.8	-1.8	-0.2	0.8	-1.9	-2.4	-0.5	-2.0	-1.6	-1.7	0.2	-0.5	-0.9
Qualifications: CSEs or equivalent	1.4	1.9	3.1	-0.9	1.0	1.2	1.8	0.8	1.4	1.7	1.7	1.4	1.4	1.5	1.4
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	5.5	0.1	0.4	1.7	2.1	0.5	1.5	2.3	2.4	2.2	1.8	2.0	2.2
Financial difficulties in last 2 years	1.4	1.9	10.2	-0.1	-3.2	1.0	0.5	-2.0	-0.2	0.6	0.8	1.0	1.6	1.1	1.3
Mouth/teeth dental problems	1.4	2.2	5.0	1.3	-1.5	-1.3	-2.0	-0.4	-1.9	-1.0	-1.3	-1.3	-0.7	-1.6	-2.2
Lung cancer (father)	1.4	1.6	4.0	1.9	0.3	-1.7	-0.8	0.7	-1.2	-0.5	-1.0	-0.4	-1.6	-2.0	-1.4
Illnesses of mother	1.4	1.8	4.3	-1.2	-1.4	1.2	1.2	-0.6	0.5	1.2	1.5	1.0	2.1	1.9	1.3
Exposure to tobacco smoke at home	1.4	1.6	5.3	-0.1	2.3	-0.2	1.5	2.2	1.5	1.3	0.8	1.1	-0.5	0.3	0.6
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	4.3	1.9	-0.4	-2.1	-1.4	0.5	-1.8	-0.3	-1.3	-0.7	-1.9	-1.9	-1.9
Medication: Ibuprofen	1.4	1.6	4.1	-0.4	0.0	1.3	2.0	2.0	1.9	1.5	1.0	1.0	-0.5	0.8	1.2
Alcohol intake frequency.	1.4	3.2	6.0	-1.4	1.7	2.0	2.2	1.1	2.4	1.7	1.7	1.7	0.9	1.8	2.3
Basal cell carcinoma (self-reported)	1.4	1.6	3.3	-0.3	0.0	0.9	1.4	-1.0	0.3	1.2	1.6	1.8	1.7	1.5	1.6
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	5.2	-2.0	-0.8	2.3	1.4	-0.0	1.6	0.8	0.9	0.6	1.0	1.6	1.5
Prostate Cancer	1.3	1.8	4.7	-0.1	-1.2	1.2	1.1	-2.1	-0.1	0.5	1.3	0.9	2.2	1.7	1.6
Bipolar Disorder (2011)	1.3	1.2	3.7	0.1	0.4	-0.5	1.3	0.3	0.4	1.9	1.5	1.9	0.5	1.1	1.2
Lung FVC	1.3	6.8	14.9	-2.6	-0.7	3.9	2.1	-0.9	2.3	2.0	2.4	2.4	2.7	3.3	3.8
Depression (self-reported)	1.3	1.6	3.2	0.1	-0.8	-1.2	-1.4	-1.0	-1.5	-1.7	-1.5	-1.8	-0.4	-1.2	-1.3
Forced vital capacity (FVC), Best measure	1.3	4.9	10.4	-3.2	-0.9	3.1	1.8	-1.1	1.8	1.1	1.7	0.8	2.8	3.2	2.8
Friendships satisfaction	1.3	1.7	3.5	-0.5	0.1	1.2	1.4	-0.5	0.6	1.2	1.7	1.3	1.9	1.8	1.7
Eye problems/disorders: Cataract	1.3	1.6	4.6	0.0	1.4	-0.9	-0.8	1.3	-0.0	-1.1	-1.4	-1.0	-2.1	-1.8	-1.3
Medication: Atorvastatin	1.3	1.6	4.0	0.6	-0.2	0.7	2.0	0.7	0.8	1.8	1.7	1.6	0.8	1.3	1.2
Schizophrenia vs Biploar Disorder	1.2	1.6	4.3	-1.7	0.2	0.4	-2.1	-0.9	-0.4	-1.7	-1.8	-1.6	-0.4	-1.0	-1.2
Primary Biliary Cirrhosis	1.2	1.8	4.6	-0.0	0.2	-0.8	-2.1	-0.5	-0.7	-1.7	-2.0	-0.9	-1.9	-1.8	-0.9
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.8	-0.1	-0.6	-0.5	-1.3	-0.8	-0.9	-1.6	-1.7	-1.6	-1.2	-1.5	-1.3
BMI	1.2	7.1	10.6	-1.3	1.8	3.3	3.1	1.0	3.2	2.9	3.0	2.3	2.8	3.2	2.8
Allergy or Eczema	1.2	3.2	12.3	-0.3	-2.8	0.5	-2.0	-3.5	-2.2	-0.6	0.2	-0.4	2.7	0.9	-0.4
Leg fat-free mass (left)	1.2	6.2	12.3	-1.7	0.1	3.0	2.7	-0.7	2.3	2.2	2.7	1.9	3.2	3.5	3.2
High blood pressure (mother)	1.2	1.7	3.5	1.9	-0.3	-1.7	-0.9	0.6	-0.9	-0.8	-1.3	-1.0	-1.6	-1.8	-1.7
Body mass index (BMI)	1.2	5.2	7.9	-0.6	1.6	2.1	2.7	0.8	2.4	2.8	2.8	2.7	2.1	2.5	2.7
Leg predicted mass (left)	1.2	6.4	12.8	-1.7	-0.0	3.0	2.7	-0.8	2.2	2.2	2.7	2.0	3.3	3.6	3.3
Nervous feelings	1.2	2.3	4.5	-1.7	2.0	-0.3	-1.0	0.9	0.8	-2.1	-2.0	-2.0	-2.0	-0.9	-0.6
Fluid intelligence score	1.2	2.5	5.4	1.3	-2.2	-1.3	-1.6	-1.9	-2.3	-1.8	-1.3	-1.7	-0.3	-0.9	-1.2
Pulse wave reflection index	1.2	1.4	3.0	0.8	-0.0	-1.2	-1.5	0.0	-1.3	-1.0	-1.3	-1.0	-1.1	-1.7	-1.7
Loud music exposure frequency	1.2	1.3	4.3	0.7	0.7	0.5	1.2	0.5	0.4	1.6	1.6	2.1	1.0	0.8	1.1
Blood clot in the leg (DVT)	1.2	1.5	4.4	-2.0	-0.4	2.1	1.3	0.0	1.5	0.6	0.7	0.4	0.9	1.4	1.3
Pulse rate, automated reading	1.2	3.9	8.7	1.0	1.0	-2.2	-3.0	-1.1	-2.1	-2.2	-2.4	-1.5	-1.7	-2.4	-2.0
Smoking status: Previous	1.2	1.7	4.0	-0.2	2.0	0.6	1.7	1.1	1.3	1.7	1.3	1.6	0.3	0.9	1.6
Leg fat-free mass (right)	1.2	6.6	13.7	-1.8	-0.1	3.0	2.8	-0.7	2.3	2.3	2.8	2.0	3.4	3.7	3.4
Average weekly red wine intake	1.2	1.7	5.6	2.4	-2.2	-1.9	-0.4	-1.2	-2.0	0.2	0.1	0.2	0.3	-0.5	-0.6
Leg predicted mass (right)	1.2	6.6	13.7	-1.7	-0.1	3.0	2.8	-0.7	2.2	2.4	2.9	2.1	3.3	3.7	3.4
Age started oral contraceptive pill	1.2	1.5	4.6	-1.8	2.1	0.9	0.5	1.4	1.5	-1.0	-0.8	-1.4	-1.4	-0.2	-0.2
Depression (Nagel 2018)	1.1	1.7	3.9	1.0	-1.7	-0.3	1.2	-0.8	-0.7	1.9	1.6	2.0	1.4	0.8	0.9
Neuroticism	1.1	2.6	5.1	0.6	-0.7	-2.1	-2.2	-1.6	-2.3	-1.4	-1.9	-1.0	-1.5	-1.7	-1.2
Medication for hormone replacement therapy	1.1	1.2	5.0	-1.8	0.0	2.2	0.1	-1.3	1.0	-0.4	-0.1	-0.4	0.9	1.0	1.3
Average weekly fortified wine intake	1.1	1.3	2.9	1.3	-1.1	-1.7	-1.2	-0.5	-1.7	-0.9	-0.9	-0.9	-0.6	-1.1	-1.3
Taking other prescription medications	1.1	1.7	8.8	-1.1	-1.2	-0.1	-1.7	-3.0	-1.3	-1.3	-1.0	-0.7	0.9	-0.0	-0.1
Hearing difficulty/problems with background noise	1.1	1.8	5.0	-0.2	-0.6	-0.4	-2.0	-2.2	-1.4	-2.0	-1.6	-1.3	-0.5	-0.9	-0.7
Medication: Cholesterol lowering	1.1	1.7	3.2	-0.1	0.7	1.2	1.3	-0.7	0.7	1.3	1.6	1.6	1.8	1.8	1.7
Breastfed as a baby	1.1	1.3	4.2	-2.0	0.6	1.0	-1.1	-0.9	0.0	-1.7	-1.5	-1.6	-0.2	-0.4	-0.5
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	3.5	-0.6	-0.0	1.6	1.9	1.3	1.8	0.9	1.1	0.5	0.4	1.4	1.3
Medication: Paracetamol	1.1	1.8	4.0	-0.9	0.3	1.3	2.0	0.1	1.4	1.6	1.4	1.4	0.9	1.5	2.0
Eye problems/disorders: None of the above	1.1	1.3	3.1	-0.5	-0.5	1.0	1.0	0.3	0.8	1.5	1.5	1.1	1.8	1.6	0.9
Medication: Allopurinol	1.1	1.4	3.6	1.4	-0.8	-1.8	-1.5	-0.9	-1.9	-0.5	-0.8	-0.6	-0.3	-1.2	-1.4
Number of full sisters	1.1	1.3	4.1	0.4	0.7	0.5	1.5	1.4	0.7	2.0	1.5	1.7	0.3	0.4	0.7
Risk taking	1.1	1.6	4.4	1.8	-1.9	-1.3	-0.2	-1.7	-2.1	0.8	0.8	1.3	1.1	0.1	0.1
Ulcerative Colitis (UC)	1.0	1.9	4.0	1.7	-0.1	-2.0	-1.4	0.3	-1.4	-1.1	-1.2	-1.0	-1.7	-1.6	-1.7
HDL Cholesterol	1.0	1.7	3.2	0.7	-0.3	-1.2	-1.6	-0.3	-1.2	-1.8	-1.6	-1.7	-1.2	-1.3	-1.5
Frequency of depressed mood in last 2 weeks	1.0	1.5	7.4	0.5	-2.7	0.0	0.1	-1.8	-0.8	0.6	0.8	0.9	1.6	1.0	0.8
Systolic blood pressure, automated reading	1.0	2.9	6.2	1.1	0.9	-1.3	-1.1	1.2	-0.4	-1.5	-1.9	-2.2	-2.3	-2.3	-2.5
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.4	-0.5	-0.6	-0.5	-1.0	0.2	-0.4	-1.4	-1.5	-1.3	-1.6	-1.4	-1.1
Allergy	1.0	2.3	9.1	0.8	2.1	-0.1	2.2	3.0	1.8	1.3	0.9	0.9	-1.2	-0.0	0.7
Hip circumference	1.0	4.2	8.5	-0.2	1.6	1.1	2.5	0.7	1.7	2.8	2.6	2.9	2.0	2.2	2.4
Gout (self-reported)	1.0	1.4	4.6	1.0	-1.5	-1.4	-1.6	-1.5	-2.1	-0.2	-0.5	-0.1	0.3	-0.8	-1.0
Number of self-reported non-cancer illnesses	1.0	1.7	9.3	-1.7	-1.0	0.8	-0.7	-3.1	-0.4	-0.8	-0.1	-0.2	1.9	1.0	0.8
Average weekly champagne plus white wine intake	1.0	1.3	2.2	0.9	-1.4	-0.1	0.7	-1.1	-0.6	1.3	1.4	1.5	1.5	1.2	1.2
Neuroticism (2016)	0.9	1.3	3.6	-1.0	-0.0	0.0	-1.8	-1.6	-0.7	-1.9	-1.7	-1.0	-0.8	-0.6	0.1
Medication: Metformin	0.9	1.2	3.2	1.8	0.6	-1.7	-0.3	0.0	-1.3	-0.5	-0.7	-0.1	-1.4	-1.5	-1.1
Diabetes (mother)	0.9	1.1	3.8	-0.6	1.0	0.8	1.5	1.9	1.7	1.0	0.6	0.6	-0.6	0.3	0.6
Stomach or abdominal pain in last month	0.9	1.1	2.3	-0.1	-0.7	-0.8	-1.0	-0.5	-0.9	-1.1	-1.4	-1.5	-1.0	-1.1	-1.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	6.8	-0.5	1.2	0.1	0.6	2.6	1.3	1.1	0.6	0.6	0.2	-0.2	-0.4
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	5.5	0.4	-2.0	0.1	-0.8	-2.3	-1.0	-0.3	0.3	0.2	1.7	0.5	0.4
Weight	0.9	4.4	9.6	-1.1	0.2	2.2	2.2	-1.0	1.5	2.1	2.5	2.0	3.1	2.9	2.5
Medication: Ventolin 100micrograms inhaler	0.9	1.2	3.1	-1.8	1.5	0.3	-1.3	-0.3	0.1	-1.3	-1.6	-1.1	-1.0	-0.6	-0.6
Emphysema/chronic bronchitis	0.9	1.1	3.8	1.1	0.9	-1.9	-0.5	0.1	-0.9	-0.4	-1.0	-0.4	-1.2	-1.3	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	3.3	0.6	-1.8	-1.2	-0.7	-1.8	-1.4	-0.1	0.2	0.7	0.8	0.2	0.5
Osteoporosis (self-reported)	0.9	1.2	4.9	1.9	-0.8	-2.2	-0.2	0.3	-1.4	0.7	0.1	0.8	-0.6	-0.8	-0.6
Miserableness	0.9	1.5	5.6	1.3	-0.4	-0.3	1.3	0.9	0.2	2.4	1.6	2.1	0.4	0.6	0.9
Financial situation satisfaction	0.9	1.2	6.1	2.5	-0.5	-1.4	0.6	-0.1	-1.3	1.0	0.9	1.3	0.3	-0.1	0.0
Neuroticism (Nagel 2018)	0.8	1.8	4.1	1.0	-0.2	-2.0	-1.7	-1.2	-1.9	-0.9	-1.5	-0.2	-1.5	-1.7	-0.9
Ulcerative Colitis	0.8	1.2	5.7	2.4	0.0	-1.6	-0.5	1.1	-1.0	0.1	-0.2	-0.1	-1.0	-1.0	-1.3
Smoking Status	0.8	2.0	3.2	1.3	-0.5	-1.6	-1.7	-1.5	-1.6	-1.5	-1.7	-0.9	-1.1	-1.8	-0.9
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	6.2	-0.1	-0.5	-0.5	-0.5	-2.5	-1.1	-0.4	0.3	0.3	1.6	0.9	0.8
Medication: Co-codamol	0.8	0.9	2.0	0.5	-0.7	-0.7	-1.2	-1.2	-1.4	-1.1	-0.9	-1.0	-0.1	-0.9	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	3.1	0.6	-0.4	-0.2	1.4	0.3	0.1	1.8	1.4	1.5	0.9	0.8	0.8
High blood pressure	0.8	2.2	3.2	1.5	-0.1	-1.2	-1.8	-1.3	-1.7	-1.6	-1.7	-1.4	-1.0	-1.8	-1.6
Sitting height	0.8	5.8	14.7	-1.6	-1.1	2.6	2.3	-1.4	1.4	1.7	2.8	1.7	3.8	3.7	2.8
Mouth/teeth dental problems: Dentures	0.8	1.4	4.2	-0.5	2.1	0.3	1.3	0.6	1.2	1.2	1.1	1.6	0.4	0.9	1.5
Shortness of breath walking on level ground	0.8	0.9	2.0	-0.8	1.0	0.2	-0.8	0.7	0.8	-1.3	-1.3	-1.4	-1.2	-0.9	-0.7
Had major operations	0.8	1.0	5.9	-0.6	-1.2	-0.0	-0.9	-2.4	-0.8	-0.5	-0.1	0.1	1.4	0.4	0.1
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.2	-0.5	-1.8	0.5	0.4	-1.5	-0.1	0.5	0.6	1.2	0.9	0.7	1.1
Knee pain experienced in last month	0.8	1.2	3.2	0.0	0.9	-1.3	-0.9	0.8	-0.7	-0.8	-1.3	-0.8	-1.4	-1.8	-1.3
Medication: Gliclazide	0.8	0.9	2.6	1.6	0.1	-1.2	0.3	1.0	-0.7	-0.3	-0.5	-0.6	-1.5	-1.1	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	3.6	-1.0	0.6	1.2	1.9	0.8	1.6	1.5	1.5	1.1	1.0	1.5	1.5
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.5	1.0	-1.5	-1.0	0.2	-1.6	-1.4	0.5	0.6	1.1	1.1	0.2	0.2
Medication: Bendroflumethiazide	0.8	1.2	2.5	1.0	-0.7	-1.5	-1.3	-1.5	-1.6	-0.8	-1.0	-0.2	-0.7	-1.0	-0.7
Medication: Lisinopril	0.8	1.0	1.7	1.2	-0.7	-0.9	-1.3	0.0	-0.9	-0.7	-1.1	-1.0	-0.9	-1.2	-1.3
Vascular/heart problems diagnosed by doctor	0.8	2.1	3.1	-1.5	0.2	1.4	1.8	1.2	1.7	1.6	1.7	1.3	1.1	1.7	1.5
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.8	0.7	-0.8	0.3	0.6	-0.9	-0.4	1.4	1.3	1.7	1.2	1.1	1.1
Crohns Disease (2012)	0.7	1.1	2.9	1.7	-1.6	-1.3	-0.4	-0.7	-1.5	-0.5	-0.6	-0.6	-0.9	-0.7	-0.7
HbA1C	0.7	0.8	1.9	0.0	0.8	-0.7	-1.4	-0.6	-0.7	-1.1	-1.1	-1.1	-0.5	-0.7	-0.8
Lupus	0.7	1.0	2.7	-1.7	1.6	1.4	0.2	0.3	1.2	0.4	0.7	0.5	1.2	0.8	0.6
Sensitivity / hurt feelings	0.7	1.1	2.5	-0.2	0.6	-1.0	-1.6	-0.6	-1.2	-1.3	-1.3	-1.1	-0.7	-1.2	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	4.4	0.8	-2.1	-0.7	0.6	-1.1	-0.8	0.9	1.0	1.2	0.8	0.7	0.8
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.9	0.4	1.4	-0.2	1.3	1.1	0.5	1.3	1.1	1.0	0.2	0.4	0.6
Neck or shoulder pain in last month	0.7	0.9	2.0	1.1	-1.2	-0.0	1.2	1.3	0.4	1.4	1.1	1.2	0.1	0.4	0.7
Medication: Blood pressure	0.7	1.3	5.1	2.2	-1.3	-1.6	-0.8	-1.0	-1.6	-0.3	-0.4	-0.2	-0.5	-0.9	-0.6
Medication: Omeprazole	0.7	0.8	3.8	-1.4	-0.6	0.5	-0.5	-1.9	-0.1	-0.6	-0.1	0.1	1.2	0.8	0.9
Heart disease (mother)	0.7	0.8	2.2	0.4	0.3	0.3	1.5	0.5	0.7	0.9	1.3	1.0	0.6	1.2	1.2
Comparative height size at age 10	0.7	3.6	17.7	-1.2	-2.6	1.1	-0.5	-4.2	-1.2	-0.8	0.3	-0.7	3.1	1.8	0.9
Leg pain on walking	0.7	0.8	3.0	1.3	-1.7	-1.4	-0.1	-0.2	-1.3	0.1	-0.1	-0.2	-0.3	-0.8	-0.9
Hypertension (Self-reported)	0.7	2.0	3.5	1.4	-0.0	-1.3	-1.7	-1.1	-1.6	-1.5	-1.7	-1.4	-1.1	-1.9	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.7	-0.5	-1.0	1.2	0.8	-1.2	0.4	0.7	1.2	0.9	1.9	1.7	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.0	0.2	0.7	-0.4	1.1	0.8	0.3	1.4	1.3	0.9	0.8	0.7	0.3
Back pain experienced in last month	0.7	1.0	5.8	0.2	-2.4	-0.4	0.6	-1.5	-0.8	0.5	0.7	0.5	0.9	0.6	0.5
Commuting to job workplace: Public transport	0.7	0.8	1.9	0.2	0.1	-0.2	-1.2	-0.8	-1.0	-1.4	-1.0	-1.4	-0.1	-0.5	-1.1
Eye problems/disorders: Glaucoma	0.7	0.8	1.6	0.7	0.1	-0.5	-0.9	-0.9	-1.0	-0.9	-1.2	-0.9	-1.1	-1.3	-0.9
Irritability	0.7	1.3	4.9	0.9	-1.5	-1.6	-1.0	-2.2	-1.7	-0.3	-0.4	0.8	0.2	-0.3	0.2
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	4.8	-0.2	-1.4	-0.3	-0.7	-2.2	-1.0	-0.4	-0.1	0.2	1.1	0.5	0.6
Heart disease (siblings)	0.7	0.8	3.2	-0.2	1.8	-0.1	0.0	0.6	0.3	-1.1	-1.0	-1.3	-1.4	-0.6	-0.3
Worry (Nagel 2018)	0.6	1.3	2.7	0.5	-0.4	-1.6	-1.5	-0.8	-1.5	-1.1	-1.4	-0.5	-1.2	-1.3	-0.8
Alzheimer’s Disease (including proxy)	0.6	0.9	3.9	-2.0	0.4	0.3	-1.5	-0.8	0.2	-1.3	-1.1	-0.8	0.1	-0.4	-0.5
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.5	-0.4	-0.3	-0.1	-1.0	-1.9	-1.0	-1.6	-1.2	-1.4	-0.1	-0.7	-1.0
Number of treatments/medications taken	0.6	1.1	6.3	-1.4	-0.9	0.8	-0.2	-2.5	-0.2	-0.6	-0.3	0.0	0.8	0.8	1.1
Angina	0.6	0.8	1.7	0.3	0.4	0.6	1.3	0.3	0.8	1.0	1.1	1.3	0.6	0.9	1.2
Maternal smoking around birth	0.6	0.8	1.3	0.5	-1.0	-0.8	-0.9	-1.0	-1.1	-1.0	-1.1	-0.8	-0.9	-0.9	-0.6
Chronic bronchitis/emphysema (father)	0.6	0.7	3.1	0.0	1.8	-0.4	-0.2	0.3	-0.3	-0.4	-0.8	0.2	-1.4	-1.2	-0.3
Past tobacco smoking	0.6	1.1	2.2	0.1	-1.5	-0.3	-1.4	-0.5	-1.1	-1.3	-1.0	-1.4	-0.4	-0.7	-1.5
Heart attack	0.6	0.8	2.4	0.9	-0.6	0.2	0.6	-0.6	-0.3	1.3	1.2	1.5	0.9	0.8	1.0
Diabetes (self-reported)	0.6	0.9	1.9	0.7	0.4	-1.4	-0.6	-0.6	-1.2	-1.0	-0.9	-0.8	-0.7	-1.2	-1.2
Falls in the last year	0.6	0.8	2.0	1.2	-0.6	-1.2	0.4	-0.1	-0.8	1.4	1.0	1.3	0.6	0.3	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	3.2	1.3	-1.8	-1.1	-0.0	0.1	-0.7	-0.2	-0.3	-0.7	-0.6	-0.5	-0.6
Headache pain in last month	0.6	1.0	3.2	-0.7	0.5	0.7	1.8	1.1	1.4	0.9	0.9	0.5	-0.1	1.1	1.2
Number of full brothers	0.6	0.8	2.6	0.4	1.6	-0.3	1.2	0.7	0.1	1.5	1.1	0.6	0.7	0.6	0.4
Number of children fathered	0.6	0.6	2.1	0.2	-0.7	0.1	1.1	-0.4	0.4	0.5	1.0	1.2	0.5	0.7	1.4
Medication: Seretide 50 evohaler	0.6	0.7	1.7	0.9	-1.3	-0.9	-1.2	-1.0	-1.1	-0.2	-0.6	-0.2	-0.0	-0.7	-0.7
Illnesses of father: Heart disease	0.6	0.9	3.7	-1.5	0.1	1.9	0.3	-0.3	1.1	0.2	0.3	-0.3	1.1	1.0	0.6
Guilty feelings	0.6	0.9	4.1	-1.4	-0.9	0.7	-0.5	-2.0	-0.5	-0.5	-0.1	-0.1	0.9	1.0	0.7
High cholesterol (Self-reported)	0.6	1.1	2.7	0.4	-1.0	1.0	1.6	0.1	0.8	1.2	1.3	0.7	1.0	1.4	0.9
Medication: Paracetamol	0.6	0.9	2.0	-0.9	0.3	0.9	1.4	0.3	1.2	1.0	0.8	1.0	0.4	0.9	1.4
Diastolic blood pressure, automated reading	0.6	1.8	3.3	0.9	1.4	-1.7	-1.4	0.1	-0.8	-1.2	-1.7	-1.3	-1.4	-1.8	-1.6
Myopia	0.6	0.9	2.0	1.0	-0.3	-1.1	-1.3	0.2	-0.8	-0.9	-0.9	-0.9	-0.7	-1.2	-1.4
Depressed Affect (Nagel 2018)	0.5	1.1	3.3	1.8	-0.5	-1.4	0.2	0.3	-0.8	1.5	0.5	1.8	-0.6	-0.6	0.3
Irritable Bowel Disease (IBD)	0.5	1.2	3.7	1.8	-1.9	-1.5	-0.6	-1.0	-1.6	-0.6	-0.4	-0.4	-0.8	-0.5	-0.4
Ovarian Cancer	0.5	0.6	2.6	0.8	-1.6	-0.5	-0.2	-1.4	-1.4	-0.2	-0.1	-0.4	0.3	0.1	-0.3
Mean Putamen Volume	0.5	0.6	4.1	-0.3	2.0	0.0	0.2	1.4	0.3	0.5	0.1	0.0	-0.8	-0.2	-0.2
Blood Red Count	0.5	5.2	17.1	2.8	-4.1	-2.0	-2.7	-1.8	-3.8	-0.5	-0.7	-0.8	0.2	-1.3	-2.4
Respiratory disease	0.5	1.2	2.9	-1.4	-0.4	1.5	-0.2	-1.7	0.3	0.5	0.5	0.6	1.7	1.3	1.0
Relative age of first facial hair	0.5	1.0	2.7	-0.5	1.5	-0.5	-1.6	-0.7	-0.5	-1.4	-1.3	-1.1	-0.2	-0.8	-0.6
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.6	-1.0	0.5	0.1	-0.6	-0.6	-0.2	-1.2	-1.2	-0.9	-0.9	-0.7	-0.3
Supplements: Zinc	0.5	0.6	3.2	1.8	-0.3	-0.8	-0.5	-0.8	-1.1	0.1	0.4	0.3	0.5	-0.3	-0.4
Supplements: Glucosamine	0.5	0.6	1.2	0.0	-0.9	0.5	0.7	-1.0	-0.2	0.6	0.9	0.7	1.1	1.1	1.1
Medication: Ramipril	0.5	0.6	2.4	0.2	-0.8	0.0	0.4	-0.8	0.1	0.9	0.8	1.6	0.9	0.7	1.0
Prospective memory result	0.5	0.6	2.0	0.9	-0.2	-0.8	-0.8	0.2	-0.7	-0.6	-0.8	-0.3	-1.4	-1.3	-0.6
Arm fat mass (right)	0.5	1.9	2.7	-0.7	1.2	1.4	1.5	0.3	1.5	1.6	1.6	1.5	1.5	1.5	1.4
High blood pressure (siblings)	0.5	0.7	1.6	0.1	-0.2	0.2	-1.0	0.1	-0.3	-1.0	-1.1	-1.3	-0.7	-1.0	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.2	-0.0	0.9	-1.0	-1.0	-0.3	-0.6	-1.0	-1.1	-0.8	-0.6	-0.9	-0.9
Chest pain or discomfort	0.5	0.7	1.8	0.4	0.4	-0.1	0.9	-0.8	0.1	1.0	1.0	1.3	0.8	0.8	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.9	0.5	1.7	-0.4	0.5	1.5	0.4	0.5	0.2	0.4	-0.4	-0.7	-0.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	4.4	-0.9	2.1	0.7	0.0	0.7	0.7	-0.1	-0.2	-0.3	-0.3	-0.0	-0.3
Illnesses of siblings: Diabetes	0.5	0.7	2.0	1.1	-0.5	-0.6	-0.9	-1.2	-1.4	-0.8	-0.5	-0.4	-0.3	-0.5	-0.5
Mood swings	0.5	1.0	4.1	-0.2	0.4	-0.2	0.9	0.2	0.3	1.5	1.2	2.0	0.4	0.9	1.4
Diabetes diagnosed by doctor	0.5	0.8	1.7	1.0	0.1	-1.3	-0.5	-0.7	-1.3	-0.8	-0.7	-0.6	-0.5	-1.1	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	6.0	0.0	-0.6	-0.2	-0.9	-2.4	-1.2	-0.7	-0.1	0.1	0.8	0.2	0.4
Mineral and other dietary supplements	0.5	0.7	1.7	0.3	-0.6	-0.8	-1.3	-0.0	-0.6	-0.9	-1.0	-0.8	-0.7	-0.8	-1.3
Arm fat mass (left)	0.5	2.0	2.6	-0.8	1.4	1.4	1.6	0.3	1.6	1.6	1.6	1.4	1.6	1.6	1.5
Illnesses of father: High blood pressure	0.5	0.6	1.8	1.1	-0.3	-0.3	0.6	0.5	0.1	1.2	1.0	1.4	0.3	0.4	0.8
Ever smoked	0.5	0.8	2.3	-0.1	0.2	0.3	1.1	0.0	0.8	1.1	1.0	1.4	0.6	0.8	1.5
Number of operations (self-reported)	0.5	0.7	1.6	-1.0	-0.2	0.4	1.1	0.2	0.6	1.2	0.8	1.3	0.6	0.7	1.1
Ever depressed for a whole week	0.5	0.6	2.1	-0.6	0.3	0.5	0.2	-1.4	-0.0	-0.0	0.5	0.0	1.3	1.0	1.0
Cholesterol lowering medication	0.5	0.7	1.3	1.0	-1.2	0.0	0.8	-0.2	-0.3	1.2	1.0	1.0	1.0	0.6	0.4
Alcohol drinker status: Previous	0.5	0.6	1.7	1.1	1.3	-1.0	0.1	1.1	-0.3	0.5	-0.0	0.3	-0.7	-0.8	-0.4
Crohns Disease (2017)	0.4	1.0	6.2	0.8	-2.5	-0.4	0.3	-1.6	-1.0	-0.2	0.1	-0.1	0.1	0.6	0.8
Rheumatoid Arthritis	0.4	0.6	2.6	-1.6	0.8	0.9	0.3	0.6	1.2	-0.4	-0.2	0.1	-0.5	0.4	0.7
Blood Platelet Count	0.4	5.1	13.2	-3.6	3.2	1.0	-1.8	1.6	1.1	-2.3	-2.4	-2.8	-1.9	-1.3	-2.3
Hair Pigment	0.4	12.7	27.2	1.5	-1.1	-3.4	-5.2	-2.3	-3.8	-4.5	-4.2	-3.8	-2.3	-3.8	-4.1
Pack years adult smoking proportion	0.4	0.5	2.2	0.2	0.5	-0.3	1.3	1.5	0.9	0.5	0.4	0.6	-0.8	-0.1	0.2
Qualifications: A levels/AS levels or equivalent	0.4	1.0	3.4	1.8	-0.9	-1.8	-0.7	-0.1	-1.5	-0.1	-0.4	-0.4	-0.6	-0.7	-0.7
Standing height	0.4	3.6	16.5	-1.3	-3.0	0.3	-1.0	-4.1	-1.9	-1.3	-0.3	-1.2	2.5	1.3	0.1
Worry too long after embarrassment	0.4	0.6	1.5	-0.6	-0.3	-0.1	-1.1	-0.7	-0.5	-1.1	-1.2	-1.1	-0.6	-0.6	-0.6
Qualifications: College or University degree	0.4	1.1	3.1	0.3	-1.7	0.8	1.2	-0.3	0.2	1.2	1.3	0.6	1.2	1.5	1.0
Angina (self-reported)	0.4	0.5	1.0	0.3	0.7	0.4	1.0	0.6	0.8	0.9	0.8	1.0	0.2	0.5	0.8
Family relationship satisfaction	0.4	0.5	2.6	-0.0	-0.4	0.3	-0.0	-1.6	-0.6	0.0	0.4	0.4	1.1	0.7	0.8
Asthma (self-reported)	0.4	0.8	2.4	-1.5	-0.4	1.5	-0.2	-1.4	0.3	-0.0	-0.1	-0.1	0.9	1.1	0.7
Illnesses of father: None of the above (group 1)	0.4	0.5	1.7	0.3	1.0	-0.3	0.9	1.3	0.5	0.8	0.5	0.8	-0.4	0.2	0.3
Wears glasses or contact lenses	0.4	0.4	1.4	-0.1	0.3	-0.8	-0.2	-0.3	-0.5	-0.9	-0.8	-1.2	-0.5	-0.7	-0.7
Supplements: Fish oil (including cod liver oil)	0.4	0.6	3.6	-0.4	1.9	0.3	0.4	0.9	0.6	0.1	-0.2	0.2	-0.9	-0.7	0.2
Fractured/broken bones in last 5 years	0.4	0.5	1.4	-1.1	1.2	0.0	-0.2	0.4	0.7	-0.6	-0.7	0.1	-1.1	-0.4	0.4
Supplements: Calcium	0.4	0.5	3.0	-0.4	-0.5	0.1	-0.5	-1.7	-0.9	-0.9	-0.6	-0.2	0.2	-0.0	0.4
Breast Cancer	0.3	0.8	2.9	-1.7	-1.1	0.9	-0.4	-1.3	-0.1	-0.8	-0.4	-0.9	0.5	0.6	0.2
LDL Cholesterol	0.3	0.6	2.0	1.0	-0.3	-0.3	0.7	0.7	0.2	1.4	0.9	1.2	-0.0	0.3	0.5
Height	0.3	6.4	24.0	-2.1	-4.9	1.2	-0.4	-4.9	-1.9	-1.2	0.3	-1.0	3.4	2.1	0.5
Lung FEV1/FVC ratio	0.3	1.6	4.6	0.8	-0.6	0.3	1.2	-0.5	0.2	1.8	1.8	1.8	2.1	0.9	1.1
Vitamin and mineral supplements	0.3	0.4	2.4	0.2	0.3	-0.2	0.0	1.6	0.6	0.1	-0.4	-0.4	-0.8	-0.6	-0.8
Trunk fat percentage	0.3	1.4	3.7	0.7	1.9	-1.5	-1.0	0.6	-0.7	-0.6	-1.0	-0.7	-1.0	-1.5	-1.7
Townsend deprivation index at recruitment	0.3	0.4	2.4	0.8	0.6	-0.3	0.1	1.6	0.3	0.1	0.0	-0.1	-0.5	-0.6	-0.6
Relative age voice broke	0.3	0.5	1.7	-0.5	0.6	0.4	-1.3	-0.3	-0.2	-1.1	-0.9	-1.1	0.0	-0.3	-0.5
Qualifications: None of the above	0.3	0.7	4.6	-0.8	2.1	-0.2	-0.0	0.6	0.8	-0.6	-0.7	-0.3	-1.0	-0.6	0.2
Medication: Simvastatin	0.3	0.4	2.0	0.5	0.0	-0.4	-0.6	-1.4	-0.9	-0.3	-0.0	-0.2	0.9	0.2	-0.1
Arm fat percentage (right)	0.3	1.2	4.9	0.0	2.2	0.4	1.0	1.7	1.3	1.3	0.8	1.0	-0.0	0.1	0.2
Worrier / anxious feelings	0.3	0.5	1.1	-0.6	1.0	0.4	0.8	0.6	1.0	0.5	0.5	0.6	-0.1	0.6	1.0
Asthma	0.3	0.6	2.1	-1.2	-0.6	1.1	-0.7	-1.4	-0.1	-0.3	-0.4	-0.5	0.6	0.6	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.5	0.7	0.5	-0.5	-0.9	-0.1	-0.6	-0.6	-1.0	-0.4	-0.6	-1.2	-0.9
Ever highly irritable/argumentative for 2 days	0.3	0.4	2.0	-0.3	0.8	0.5	-0.2	-1.4	-0.2	0.2	0.2	0.7	0.7	0.4	0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.6	-1.3	0.7	0.4	-0.0	1.1	0.8	-0.3	-0.4	-0.4	-0.7	-0.3	-0.2
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.7	0.6	0.6	0.0	0.5	1.2	0.4	0.2	-0.2	0.3	-1.3	-0.5	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.9	-0.6	1.4	0.4	-0.1	0.4	0.6	-0.3	-0.4	-0.5	-0.3	-0.3	-0.3
Age at first live birth	0.3	0.5	2.9	-0.1	-1.7	0.4	-0.2	-1.0	-0.3	-0.7	-0.1	-1.0	0.4	0.6	0.0
Medication: Aspirin	0.3	0.5	1.2	0.6	-0.5	0.2	0.6	-1.0	-0.5	0.5	0.8	0.5	1.1	0.8	0.5
Arm fat percentage (left)	0.3	1.0	6.5	-0.1	2.6	0.2	0.7	1.6	1.2	0.9	0.4	0.6	-0.2	-0.2	-0.1
Medication: Aspirin	0.3	0.4	0.9	0.7	-0.4	0.1	0.5	-0.9	-0.5	0.3	0.7	0.5	1.0	0.6	0.5
Alcohol drinker status: Never	0.3	0.3	1.4	0.1	1.2	-0.2	0.5	1.1	0.4	0.4	0.2	-0.2	-0.3	-0.0	-0.4
Unable to work because of sickness or disability	0.3	0.4	1.8	-0.9	-0.4	0.0	-0.7	-1.3	-0.2	-0.6	-0.7	-0.2	0.2	0.2	0.5
Pack years of smoking	0.3	0.5	2.0	0.4	0.5	-0.6	0.9	1.4	0.6	0.2	0.1	0.1	-1.0	-0.5	-0.3
Major Depression (MDD)	0.2	0.2	1.0	0.5	-0.2	-0.3	0.2	0.6	0.3	0.9	0.4	1.0	-0.2	-0.2	0.1
Triglycerides	0.2	0.3	1.0	1.0	-0.7	-0.9	-0.1	-0.8	-0.6	-0.2	-0.1	-0.1	0.2	-0.2	-0.1
Average weekly spirits intake	0.2	0.2	0.5	0.6	-0.0	-0.7	-0.3	0.0	-0.7	-0.1	-0.2	-0.4	-0.6	-0.5	-0.3
Medication: Levothyroxine sodium	0.2	0.3	1.2	-0.6	0.1	0.0	0.5	-0.5	0.7	0.4	0.4	0.9	0.2	0.6	1.1
Had menopause	0.2	0.2	0.7	-0.5	-0.3	0.1	0.2	-0.1	0.1	-0.8	-0.6	-0.8	-0.5	-0.2	-0.1
Time employed in main current job	0.2	0.2	0.9	-0.9	0.1	0.4	0.1	-0.3	0.4	-0.6	-0.6	-0.7	-0.5	0.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.2	0.9	-1.1	-0.4	-0.3	-0.8	-0.7	0.1	-0.0	0.4	0.1	-0.2	0.1
Tense / ‘highly strung’	0.2	0.4	0.9	0.2	-0.4	-0.6	-0.7	-0.9	-0.7	-0.8	-0.8	-0.5	-0.4	-0.5	-0.3
Hair/balding pattern: Pattern 4	0.2	0.6	2.6	-0.4	1.6	0.7	0.2	1.1	1.1	-0.3	-0.3	-0.3	-0.8	-0.1	0.3
Medication: Amlodipine	0.2	0.2	1.5	-0.1	-0.5	-0.4	-0.7	-1.2	-0.4	-0.3	-0.2	-0.3	0.4	-0.0	-0.1
Body fat percentage	0.2	0.8	4.1	0.7	2.0	-1.0	-0.4	0.8	-0.2	0.2	-0.4	0.2	-0.6	-1.0	-1.0
Wheeze or whistling in the chest in last year	0.2	0.4	1.7	0.9	-1.3	-0.6	0.0	-0.3	-0.7	0.6	0.1	0.8	-0.3	-0.2	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	1.2	0.6	-1.1	-0.2	0.8	0.3	0.0	0.7	0.5	0.4	-0.1	0.2	0.3
Leg fat mass (right)	0.2	0.8	1.7	0.0	1.2	0.6	0.8	0.2	0.7	1.3	1.0	1.3	1.0	0.6	0.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.8	-0.0	-0.0	0.1	-0.5	0.9	0.2	-0.3	-0.4	-0.2	-0.7	-0.7	-0.7
Medication for cholesterol	0.2	0.3	1.2	-0.0	1.1	-0.5	0.0	1.0	0.0	-0.1	-0.1	-0.0	-0.6	-0.4	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.1	0.9	1.1	-0.3	0.1	0.8	-0.0	0.6	0.1	0.2	-0.2	-0.3	-0.1
Osteoarthritis (self-reported)	0.2	0.2	0.9	0.0	-0.9	-0.5	-0.4	-0.9	-0.7	-0.0	-0.2	0.2	0.1	-0.0	0.1
Ever taken oral contraceptive pill	0.2	0.3	0.7	-0.8	-0.0	0.8	0.6	0.1	0.6	0.3	0.4	0.2	0.4	0.6	0.6
Leg fat percentage (left)	0.2	0.6	2.2	1.0	1.5	-0.7	-0.1	0.6	-0.2	0.7	0.0	0.8	-0.4	-1.0	-0.7
Commuting to job workplace: Cycle	0.2	0.2	0.5	0.3	-0.1	0.6	0.7	0.6	0.1	0.7	0.6	0.0	0.3	0.5	0.1
Pain experienced in last month	0.2	0.3	1.2	-0.0	0.5	-0.1	-1.1	-0.1	-0.1	-0.8	-0.7	-0.7	-0.2	-0.5	-0.8
Leg fat mass (left)	0.2	0.7	1.7	-0.1	1.2	0.6	0.8	0.1	0.7	1.2	0.9	1.3	0.9	0.6	0.7
Cardiovascular Disease	0.1	0.3	2.3	0.2	-0.5	0.4	-0.2	-1.5	-0.3	-0.5	-0.4	-0.2	0.4	0.1	0.3
Tanning	0.1	1.4	3.4	1.6	-1.4	-0.9	1.4	0.9	-0.1	1.8	1.5	1.6	0.2	0.4	0.8
Multivitamins +/- minerals	0.1	0.1	0.7	-0.7	0.9	0.2	0.1	-0.2	0.1	-0.3	-0.0	-0.2	-0.2	0.1	0.3
Medication: Atenolol	0.1	0.2	0.4	0.6	-0.2	-0.5	-0.0	-0.6	-0.5	0.1	0.5	0.4	0.7	0.2	0.0
Waist circumference	0.1	0.5	2.1	0.8	0.1	-0.6	-0.4	-1.4	-0.9	0.5	0.4	0.9	1.0	0.0	0.1
Number of incorrect matches in round	0.1	0.1	1.0	-0.5	0.0	1.0	0.3	-0.1	0.3	0.2	0.0	-0.1	0.3	-0.0	-0.2
Neuroticism score	0.1	0.2	0.4	0.1	-0.5	-0.5	-0.6	-0.6	-0.6	-0.2	-0.5	0.1	-0.4	-0.3	0.1
Pulse rate	0.1	0.2	1.1	-0.2	0.2	-0.0	-0.2	-1.1	-0.4	-0.2	-0.0	0.1	0.3	0.3	0.5
Leg fat percentage (right)	0.1	0.5	2.2	0.9	1.5	-0.5	-0.1	0.6	-0.0	0.6	0.0	0.8	-0.3	-0.9	-0.6
Migraine (self-reported)	0.1	0.2	0.8	-0.7	0.6	0.4	-0.1	-0.9	-0.1	-0.2	-0.2	-0.1	0.3	0.2	0.1
Whole body fat mass	0.1	0.3	1.1	0.0	1.1	0.1	0.3	-0.1	0.2	0.7	0.5	0.7	0.7	0.3	0.1
Overall health rating	0.1	0.2	0.8	-0.6	0.5	0.3	0.1	-0.3	0.6	-0.3	-0.3	0.4	-0.4	0.1	0.9
Age at last live birth	0.1	0.2	0.6	-0.2	-0.0	0.5	0.8	-0.0	0.2	0.6	0.5	-0.2	0.4	0.8	0.4
Loneliness, isolation	0.1	0.1	0.7	0.7	-0.8	-0.3	0.1	0.2	0.1	0.0	-0.1	0.2	-0.3	-0.1	0.4
Qualifications: nursing, teaching	0.1	0.2	0.4	-0.3	0.2	0.7	-0.5	0.4	0.5	-0.3	-0.5	-0.6	-0.3	-0.1	-0.3
Hearing aid user	0.1	0.1	0.5	-0.5	-0.1	0.5	0.2	-0.7	0.2	-0.4	-0.2	-0.2	-0.0	0.2	0.6
Medication: Blood pressure	0.1	0.3	1.1	-0.3	-0.6	0.2	-0.7	-1.0	-0.4	-0.6	-0.5	-0.5	0.1	-0.3	-0.2
Trunk fat mass	0.0	0.2	1.5	0.1	1.2	-0.5	-0.2	-0.2	-0.2	0.2	0.0	0.1	0.5	-0.1	-0.5

Hub : Genes

RNF185

Models

Trait associations