Best TWAS P=1.25e-09 · Best GWAS P=5.61e-09 conditioned to 0.541
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ZNF292 | 0.04 | 0.05 | lasso | 12 | 0.03 | 4.1e-05 | 5.0 | -5.2 | 1.8e-07 | 0.88 | 0.26 | 0.73 | FALSE |
2 | GTEx | Artery Aorta | RP11-393I2.4 | 0.10 | 0.03 | lasso | 5 | 0.02 | 2.4e-02 | 4.7 | -5.3 | 1.4e-07 | 0.75 | 0.10 | 0.82 | FALSE |
3 | GTEx | Cells EBV-transformed lymphocytes | C6orf163 | 0.18 | 0.14 | lasso | 4 | 0.15 | 1.5e-05 | 5.7 | 5.6 | 2.3e-08 | -0.79 | 0.05 | 0.92 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | SMIM8 | 0.18 | 0.14 | lasso | 5 | 0.12 | 1.4e-09 | 5.7 | -5.7 | 1.2e-08 | 0.80 | 0.03 | 0.97 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | C6orf163 | 0.16 | 0.14 | lasso | 3 | 0.18 | 2.7e-13 | 5.7 | 5.7 | 1.5e-08 | -0.72 | 0.05 | 0.95 | FALSE |
6 | GTEx | Nerve Tibial | ZNF292 | 0.09 | 0.07 | enet | 16 | 0.10 | 1.5e-07 | -5.6 | -5.7 | 1.4e-08 | 0.92 | 0.13 | 0.87 | FALSE |
7 | GTEx | Nerve Tibial | RP11-393I2.4 | 0.08 | 0.09 | enet | 18 | 0.09 | 6.8e-07 | 4.9 | -5.7 | 9.3e-09 | 0.87 | 0.05 | 0.95 | FALSE |
8 | GTEx | Stomach | C6orf163 | 0.10 | 0.06 | lasso | 1 | 0.05 | 2.3e-03 | 5.6 | 5.6 | 1.8e-08 | -0.79 | 0.04 | 0.87 | FALSE |
9 | METSIM | Adipose | C6orf164 | 0.05 | 0.06 | lasso | 8 | 0.06 | 9.3e-10 | 5.7 | 5.5 | 3.6e-08 | -0.81 | 0.05 | 0.95 | FALSE |
10 | ROSMAP | Brain Pre-frontal Cortex | SLC35A1 | 0.30 | 0.48 | enet | 25 | 0.50 | 5.7e-73 | -5.5 | -5.4 | 6.1e-08 | 0.74 | 0.09 | 0.91 | FALSE |
11 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | C6orf164 | 0.07 | 0.06 | blup | 95 | 0.05 | 2.0e-03 | -5.8 | 5.7 | 9.1e-09 | -0.95 | 0.03 | 0.95 | FALSE |
12 | The Cancer Genome Atlas | Colon Adenocarcinoma | C6orf164 | 0.05 | 0.02 | enet | 8 | 0.02 | 1.9e-02 | -5.6 | 5.4 | 7.2e-08 | -0.99 | 0.03 | 0.69 | FALSE |
13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C6orf164 | 0.06 | 0.08 | blup | 94 | 0.08 | 8.3e-09 | -5.6 | 5.4 | 6.1e-08 | -0.93 | 0.02 | 0.98 | FALSE |
14 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C6orf164 | 0.11 | 0.14 | enet | 8 | 0.12 | 1.6e-07 | -5.7 | 5.9 | 3.3e-09 | -0.99 | 0.02 | 0.98 | FALSE |
15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C6orf164 | 0.04 | 0.02 | blup | 95 | 0.04 | 5.4e-05 | 5.7 | 6.1 | 1.3e-09 | -0.92 | 0.02 | 0.98 | TRUE |
16 | The Cancer Genome Atlas | Lung Adenocarcinoma | C6orf164 | 0.09 | 0.12 | blup | 95 | 0.11 | 4.1e-13 | -5.7 | 5.5 | 4.4e-08 | -0.96 | 0.02 | 0.98 | FALSE |
17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C6orf164 | 0.06 | 0.06 | lasso | 4 | 0.07 | 4.6e-08 | -5.8 | 5.4 | 8.5e-08 | -0.97 | 0.02 | 0.98 | FALSE |
18 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C6orf163 | 0.06 | 0.02 | blup | 66 | 0.02 | 1.1e-02 | 5.6 | 5.8 | 7.4e-09 | -0.84 | 0.02 | 0.85 | FALSE |
19 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C6orf164 | 0.12 | 0.12 | blup | 95 | 0.14 | 7.4e-10 | -5.1 | 5.5 | 3.3e-08 | -0.92 | 0.03 | 0.97 | FALSE |
20 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SLC35A1 | 0.04 | 0.03 | lasso | 5 | 0.02 | 1.3e-02 | -5.5 | 5.4 | 7.1e-08 | -0.74 | 0.01 | 0.90 | FALSE |
21 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C6orf164 | 0.07 | 0.11 | enet | 8 | 0.10 | 8.4e-05 | -5.7 | 5.5 | 4.2e-08 | -0.99 | 0.03 | 0.94 | FALSE |
22 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C6orf164 | 0.17 | 0.13 | lasso | 4 | 0.10 | 6.2e-08 | -5.7 | 5.6 | 1.9e-08 | -0.98 | 0.02 | 0.98 | FALSE |
23 | The Cancer Genome Atlas | Thyroid Carcinoma | C6orf164 | 0.18 | 0.24 | lasso | 4 | 0.25 | 1.4e-24 | -5.7 | 5.7 | 9.3e-09 | -0.99 | 0.02 | 0.98 | FALSE |
24 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC35A1 | 0.08 | 0.07 | enet | 17 | 0.07 | 5.0e-07 | -5.3 | -5.3 | 1.5e-07 | 0.74 | 0.01 | 0.99 | FALSE |