TWAS hub - OR2AE1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.163	0.0535	0.0e+00	0.219	0.220	0.225	NA	0.223	7.3e-44	5.4e-44	3.7e-45	NA	1.2e-44
2	TCGA	Esophageal Carcinoma	0.179	0.1170	5.3e-03	-0.006	0.059	0.033	NA	0.007	5.7e-01	6.1e-03	3.3e-02	NA	1.8e-01
3	TCGA	Glioblastoma Multiforme	0.098	0.0580	3.7e-03	0.038	0.071	0.050	NA	0.046	2.7e-02	3.5e-03	1.3e-02	NA	1.6e-02
4	TCGA	Brain Lower Grade Glioma	0.110	0.0464	4.4e-14	0.146	0.111	0.132	NA	0.140	2.6e-16	1.3e-12	8.2e-15	NA	1.2e-15
5	TCGA	Pheochromocytoma and Paraganglioma	0.179	0.0830	8.1e-06	0.116	0.109	0.112	NA	0.114	2.4e-05	4.4e-05	3.3e-05	NA	2.7e-05
6	TCGA	Stomach Adenocarcinoma	0.049	0.0340	2.3e-03	0.044	0.034	0.049	NA	0.031	3.6e-04	1.7e-03	1.9e-04	NA	2.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Had other major operations	11.8	14.3	16.0	3.8	4.0	3.4	3.8	3.8	3.9
Blood Platelet Count	8.2	95.4	123.2	9.5	8.6	9.9	9.7	9.6	11.1
Birth weight of first child	6.5	11.7	14.6	3.8	3.3	3.8	3.7	3.7	1.6
Bilateral oophorectomy (both ovaries removed)	6.4	7.5	9.9	2.8	2.3	2.5	2.6	2.9	3.1
Lung FEV1/FVC ratio	6.3	31.8	36.2	6.0	5.6	5.7	6.0	5.8	4.6
Impedance of arm (left)	6.3	29.3	33.0	-5.3	-5.1	-5.3	-5.4	-5.6	-5.7
Heart disease (siblings)	5.2	6.4	10.8	-2.6	-1.9	-2.0	-2.5	-2.6	-3.3
Forced expiratory volume in 1-second (FEV1)	5.0	16.9	21.1	4.6	3.9	4.3	4.5	4.5	2.4
Breast Cancer	4.9	11.8	13.3	-3.4	-3.2	-3.3	-3.5	-3.6	-3.7
Wears glasses or contact lenses	4.9	5.7	6.2	-2.4	-2.3	-2.4	-2.4	-2.5	-2.2
Impedance of whole body	4.9	24.9	27.7	-4.9	-4.6	-4.9	-5.0	-5.2	-5.3
Impedance of arm (right)	4.8	22.4	24.8	-4.6	-4.3	-4.9	-4.7	-5.0	-5.0
Forced expiratory volume in 1-second (FEV1), Best measure	4.7	15.0	18.5	4.2	3.7	4.0	4.2	4.3	2.6
Illnesses of father: None of the above (group 1)	4.4	5.4	6.1	2.2	2.4	2.2	2.2	2.4	2.5
Number of operations (self-reported)	4.4	6.5	8.3	2.9	2.4	2.4	2.8	2.7	1.9
Alcohol drinker status: Previous	4.3	4.9	6.3	2.5	1.7	2.1	2.5	2.0	2.4
Diabetes (mother)	4.1	5.3	10.4	2.1	2.1	2.1	2.1	1.9	3.2
Arm fat-free mass (left)	4.1	20.9	24.1	4.7	4.9	4.3	4.8	4.8	3.7
Arm predicted mass (left)	4.1	20.8	24.3	4.7	4.9	4.3	4.8	4.8	3.8
Arm fat-free mass (right)	3.9	19.7	22.3	4.6	4.7	4.3	4.7	4.7	3.6
Trunk predicted mass	3.8	21.5	25.2	4.9	4.8	4.5	5.0	5.0	3.3
Heart disease (mother)	3.8	4.7	6.0	-2.4	-2.3	-1.6	-2.2	-2.4	-1.8
Age started oral contraceptive pill	3.8	4.8	5.5	-2.3	-2.1	-2.0	-2.2	-2.4	-2.1
Trunk fat-free mass	3.7	21.3	25.0	4.9	4.8	4.5	5.0	5.0	3.3
Arm predicted mass (right)	3.7	19.0	21.7	4.5	4.7	4.2	4.6	4.6	3.5
Mouth/teeth dental problems: Mouth ulcers	3.7	5.9	9.5	-2.3	-3.1	-2.3	-2.5	-2.4	-1.8
Whole body water mass	3.6	20.3	23.4	4.7	4.8	4.3	4.8	4.8	3.4
Alzheimer’s Disease (including proxy)	3.5	5.1	6.4	2.4	1.9	2.4	2.5	2.5	1.7
Alzheimer’s Disease (in mother)	3.3	3.9	4.9	2.1	1.8	2.0	2.0	2.2	1.7
Whole body fat-free mass	3.3	19.0	21.8	4.5	4.6	4.2	4.7	4.7	3.2
Eye problems/disorders: Cataract	3.2	3.7	4.1	-2.0	-1.7	-2.0	-2.0	-2.0	-1.8
Impedance of leg (left)	3.1	15.1	17.4	-3.9	-3.5	-3.7	-4.0	-4.2	-4.0
Breast cancer (self-reported)	3.1	3.7	5.8	1.9	1.9	2.0	1.8	2.4	1.3
Basal metabolic rate	3.0	16.5	19.7	4.2	4.4	3.9	4.3	4.3	3.1
Impedance of leg (right)	2.9	13.8	16.5	-3.6	-3.4	-3.5	-3.7	-3.9	-4.1
Lung cancer (father)	2.9	3.4	5.9	1.7	1.6	1.6	1.7	1.9	2.4
Alcohol drinker status: Never	2.9	3.5	5.7	-1.7	-2.4	-1.8	-1.8	-1.8	-1.6
Peak expiratory flow (PEF)	2.8	6.4	8.5	2.9	2.2	2.5	2.8	2.9	1.4
Noisy workplace	2.7	3.3	4.0	1.9	2.0	1.8	1.8	1.9	1.4
Overall health rating	2.7	5.9	6.6	2.3	2.6	2.3	2.6	2.3	2.6
Ulcerative Colitis	2.6	3.7	4.8	2.2	1.7	1.8	2.2	1.9	1.7
Average weekly spirits intake	2.6	3.2	4.5	1.6	2.1	1.7	1.8	1.7	1.7
Ever used hormone-replacement therapy (HRT)	2.6	3.4	5.1	1.8	1.3	2.2	1.8	1.7	2.0
Eye problems/disorders: None of the above	2.6	3.0	6.0	1.7	2.4	1.4	1.8	1.8	0.9
Leg fat-free mass (right)	2.6	13.9	15.9	3.8	4.0	3.5	4.0	3.9	3.0
Leg fat-free mass (left)	2.5	13.4	15.8	3.8	4.0	3.5	3.9	3.9	2.8
Leg predicted mass (left)	2.5	13.0	15.2	3.8	3.9	3.4	3.8	3.8	2.8
Serious illness, injury or assault of a close relative in last 2 years	2.5	2.9	3.3	-1.8	-1.8	-1.7	-1.7	-1.8	-1.4
Leg predicted mass (right)	2.5	13.6	15.7	3.8	4.0	3.5	3.9	3.9	3.0
Handedness (chirality/laterality): Left-handed	2.4	2.9	4.0	1.6	1.8	2.0	1.8	1.5	1.4
Exposure to tobacco smoke at home	2.3	2.5	5.6	1.6	0.9	1.4	1.4	1.6	2.4
Knee pain experienced in last month	2.3	3.6	5.6	1.9	1.6	1.7	1.9	1.8	2.4
Illnesses of father: High blood pressure	2.3	2.8	3.7	-1.6	-1.5	-1.7	-1.6	-1.9	-1.7
Ever had hysterectomy (womb removed)	2.2	2.4	3.0	1.6	1.7	1.2	1.6	1.6	1.6
Medication for hormone replacement therapy	2.2	2.4	3.7	1.5	1.9	1.4	1.6	1.5	1.3
Ever had prostate specific antigen (PSA) test	2.2	2.6	3.4	-1.6	-1.4	-1.6	-1.7	-1.4	-1.9
Back pain experienced in last month	2.1	3.0	3.3	1.6	1.7	1.8	1.8	1.8	1.7
Irritability	2.1	3.6	5.2	-2.0	-1.7	-2.3	-1.9	-2.0	-1.2
Depression (Nagel 2018)	2.0	3.0	3.6	-1.8	-1.3	-1.9	-1.8	-1.9	-1.6
Coronary Artery Disease (CAD)	2.0	2.4	3.5	-1.6	-1.3	-1.9	-1.6	-1.8	-1.1
Medication for cholesterol, blood pressure or diabetes	2.0	3.2	4.6	2.0	1.5	1.8	1.8	2.1	1.5
Multivitamins +/- minerals	1.9	2.4	3.3	1.4	1.4	1.3	1.3	1.8	1.8
Number of incorrect matches in round	1.9	3.2	6.6	-1.5	-2.6	-1.4	-1.8	-1.6	-1.6
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	3.2	-1.5	-0.8	-1.8	-1.6	-1.5	-1.7
Taking other prescription medications	1.8	2.8	4.4	-1.6	-1.3	-2.1	-1.7	-1.6	-1.7
Serious illness, injury or assault to yourself	1.7	2.1	3.8	1.5	2.0	0.7	1.5	1.5	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	3.1	-1.4	-1.8	-1.5	-1.4	-1.7	-0.8
Illnesses of mother	1.6	2.0	2.6	1.4	1.5	1.3	1.5	1.6	1.0
Angina (self-reported)	1.6	2.1	3.1	-1.8	-1.1	-1.6	-1.6	-1.6	-0.6
Illnesses of father: Heart disease	1.6	2.3	2.9	-1.4	-1.5	-1.4	-1.5	-1.7	-1.4
Prostate Cancer	1.5	2.1	2.8	1.6	1.1	1.3	1.4	1.4	1.7
Angina	1.5	2.0	3.0	-1.7	-1.0	-1.5	-1.6	-1.6	-0.6
Weight	1.5	7.6	10.7	2.7	3.3	2.4	2.9	2.7	2.5
Chronic bronchitis/emphysema (mother)	1.5	1.7	2.3	-1.3	-1.5	-1.5	-1.4	-1.4	-0.4
Forced vital capacity (FVC), Best measure	1.5	5.4	7.2	2.6	2.2	2.4	2.5	2.7	1.2
Suffer from ‘nerves’	1.5	2.4	3.4	1.8	1.2	1.7	1.6	1.8	0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.2	4.1	1.7	1.4	2.0	1.9	1.7	1.8
Risk taking	1.5	2.1	3.8	1.5	1.1	1.9	1.6	1.6	0.7
Forced vital capacity (FVC)	1.4	5.4	7.3	2.7	2.2	2.4	2.7	2.6	0.8
Fluid intelligence score	1.4	2.8	4.2	-1.6	-1.6	-1.9	-1.4	-2.0	-1.5
Medication: Cholesterol lowering	1.4	2.1	3.0	-1.6	-0.9	-1.7	-1.3	-1.7	-1.4
Age at last live birth	1.4	2.1	4.3	-1.0	-2.1	-1.4	-1.3	-1.4	-1.3
Fractured/broken bones in last 5 years	1.4	1.8	2.6	1.6	0.9	1.4	1.4	1.6	1.0
Ulcerative Colitis (UC)	1.3	2.4	3.8	1.9	1.4	1.2	1.8	1.6	1.4
BMI	1.3	7.8	17.2	2.2	2.9	2.4	2.4	2.2	4.2
Sitting height	1.3	9.3	12.2	3.5	3.4	2.8	3.4	3.5	0.6
Mouth/teeth dental problems: Loose teeth	1.3	1.6	2.2	-1.4	-1.3	-1.1	-1.5	-1.2	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	2.0	1.4	1.4	0.9	1.4	1.3	1.1
Illnesses of siblings: Diabetes	1.3	1.6	2.6	1.4	1.1	0.8	1.2	1.2	1.6
Heel T-Score	1.2	9.9	17.1	-3.3	-4.1	-2.5	-3.3	-3.6	-1.4
Average weekly fortified wine intake	1.2	1.4	2.0	-1.4	-0.6	-1.3	-1.3	-1.0	-1.3
Number of full sisters	1.2	1.5	2.1	-1.3	-1.1	-1.2	-1.5	-1.2	-1.0
Osteoporosis (self-reported)	1.2	1.5	2.1	-1.3	-1.0	-1.5	-1.3	-1.3	-0.8
Ever smoked	1.2	2.2	3.7	1.0	1.6	1.7	1.3	1.2	1.9
Schizophrenia vs Biploar Disorder	1.1	1.5	3.7	1.2	1.9	0.7	1.2	1.3	0.2
Major Depression (MDD)	1.1	1.4	2.3	1.2	0.4	1.3	1.2	1.0	1.5
Stomach or abdominal pain in last month	1.1	1.3	2.4	1.0	1.6	0.8	1.2	1.4	0.8
Body mass index (BMI)	1.1	4.5	9.0	1.8	2.1	1.8	1.9	1.8	3.0
Diabetes (self-reported)	1.1	1.6	3.3	0.9	0.9	1.4	1.3	1.1	1.8
Alcohol intake versus 10 years previously	1.1	1.7	2.5	-1.6	-1.0	-1.4	-1.6	-1.4	-0.4
Medication: Ibuprofen	1.1	1.3	2.4	-1.3	-1.6	-0.6	-1.2	-1.1	-0.9
Long-standing illness, disability or infirmity	1.1	1.8	2.2	-1.3	-1.5	-1.4	-1.3	-1.4	-1.2
Diabetes diagnosed by doctor	1.1	1.8	2.9	1.1	1.3	1.3	1.5	1.1	1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	3.7	-1.6	-1.9	-1.1	-1.5	-1.8	-1.0
Length of working week for main job	1.0	1.1	1.5	1.0	1.0	1.1	1.1	1.2	0.9
Medication: Gliclazide	1.0	1.1	2.2	0.8	0.7	1.2	0.9	1.0	1.5
Medication: Atorvastatin	1.0	1.2	1.6	-1.3	-1.1	-1.1	-1.2	-1.0	-0.8
Myopia	1.0	1.5	1.8	-1.3	-1.3	-1.3	-1.2	-1.2	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	4.0	0.8	0.7	0.9	0.8	0.8	2.0
Lupus	0.9	1.4	2.2	1.1	1.4	0.8	1.1	1.0	1.5
High blood pressure (mother)	0.9	1.3	1.7	-1.1	-1.3	-1.1	-1.2	-1.0	-1.2
Waist circumference	0.9	3.4	5.5	1.6	2.1	1.5	1.8	1.5	2.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.5	1.0	0.6	1.2	1.0	1.2	1.0
Mouth/teeth dental problems	0.9	1.3	1.8	1.3	1.2	1.2	1.2	1.1	0.6
Qualifications: College or University degree	0.9	2.8	3.7	-1.7	-1.1	-1.9	-1.7	-1.6	-1.9
Migraine (self-reported)	0.9	1.1	1.6	1.3	1.0	0.9	1.2	1.1	0.7
Medication: Omeprazole	0.9	1.1	4.3	0.7	0.4	0.9	0.7	0.6	2.1
Medication: Seretide 50 evohaler	0.9	1.0	1.6	-1.3	-0.8	-1.0	-1.2	-0.9	-0.8
Had major operations	0.9	1.1	1.6	1.2	0.9	0.9	1.2	1.1	0.7
Number of self-reported non-cancer illnesses	0.9	1.6	1.9	-1.4	-1.2	-1.4	-1.3	-1.3	-1.2
Alzheimer’s Disease (in father)	0.8	0.8	1.3	0.9	0.7	1.0	1.0	1.1	0.5
Ovarian Cancer	0.8	1.1	1.5	1.1	1.2	0.8	1.2	0.7	1.1
LDL Cholesterol	0.8	1.2	1.6	-1.1	-0.8	-1.1	-1.2	-1.0	-1.3
Blood Red Count	0.8	7.7	15.8	-2.0	-0.5	-3.3	-2.2	-3.2	-4.0
Type 2 Diabetes (T2D) (2018)	0.8	1.5	2.9	0.7	1.5	1.1	1.0	0.9	1.7
Medication: Metformin	0.8	1.1	2.1	0.8	0.9	1.1	0.9	0.9	1.5
Ever had bowel cancer screening	0.8	1.0	1.4	-0.8	-1.2	-1.0	-1.0	-0.9	-1.0
Smoking status: Current	0.8	1.3	2.2	1.0	1.0	1.1	1.1	1.0	1.5
Financial situation satisfaction	0.8	1.0	1.8	0.9	0.8	0.9	1.0	1.0	1.3
Bipolar Disorder (2018)	0.7	1.1	2.3	-1.0	-1.5	-0.9	-1.1	-1.2	-0.1
Smoking Status	0.7	1.6	2.5	0.8	1.4	1.5	1.1	1.1	1.6
Vitamin and mineral supplements	0.7	0.9	1.7	-0.7	-0.6	-0.9	-0.6	-1.2	-1.3
Townsend deprivation index at recruitment	0.7	1.0	1.6	-1.3	-0.7	-0.9	-1.2	-1.0	-0.9
Age when periods started (menarche)	0.7	1.6	2.8	-1.2	-0.9	-1.7	-1.3	-1.3	-1.1
Time employed in main current job	0.7	0.8	1.3	-1.0	-0.5	-1.1	-1.0	-1.0	-0.4
Arm fat mass (right)	0.7	3.1	4.7	1.6	2.1	1.4	1.6	1.6	2.2
Comparative body size at age 10	0.7	2.0	2.5	-1.6	-1.4	-1.4	-1.4	-1.4	-1.2
Osteoarthritis (self-reported)	0.7	0.9	1.2	0.9	0.7	1.0	1.0	0.9	1.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.3	-1.0	-0.5	-1.1	-1.0	-0.9	-0.5
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.3	0.9	0.9	1.1	1.0	0.7	1.1
Pain experienced in last month	0.7	1.2	1.5	-1.1	-1.2	-0.9	-1.2	-0.9	-1.2
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.8	-1.0	-0.7	-0.9	-0.9	-0.9	-1.3
Intelligence (Savage-Jansen 2018)	0.6	1.9	2.8	-1.4	-1.2	-1.3	-1.3	-1.7	-1.3
Worry (Nagel 2018)	0.6	1.3	1.8	1.3	1.2	1.2	1.4	1.1	0.4
HbA1C	0.6	0.6	1.3	-0.9	-0.7	-1.1	-0.8	-0.5	-0.4
Blood White Count	0.6	4.8	9.2	1.6	2.8	1.6	1.6	2.0	3.0
Lung FVC	0.6	3.2	5.4	-1.7	-2.3	-1.3	-1.8	-1.5	-1.8
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.1	0.6	0.5	0.7	0.8	0.5	1.5
Current tobacco smoking	0.6	1.0	2.1	0.8	0.9	0.9	0.9	0.8	1.4
Relative age voice broke	0.6	1.0	1.3	-0.9	-1.1	-1.0	-1.0	-1.1	-0.8
Chronic bronchitis/emphysema (father)	0.6	0.7	0.9	-0.9	-0.9	-1.0	-1.0	-0.7	-0.3
Heart attack	0.6	0.8	1.5	-1.0	-0.6	-0.8	-0.9	-0.9	-1.2
Illnesses of siblings	0.6	0.8	1.3	0.8	0.5	0.8	0.9	1.0	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.8	-1.0	-1.3	-0.2	-0.8	-0.8	-0.6
Pulse wave reflection index	0.6	0.7	2.6	-0.5	-1.6	-0.0	-0.7	-0.8	-0.7
Glaucoma (self-reported)	0.6	0.7	1.2	-0.5	-1.1	-0.4	-0.6	-0.9	-1.1
Birth weight	0.6	1.3	3.7	1.2	1.9	0.4	1.3	0.9	0.1
Comparative height size at age 10	0.6	3.4	7.1	1.9	2.7	1.2	2.1	1.9	0.6
Leg pain on walking	0.6	0.8	1.2	0.8	0.9	0.9	0.8	0.9	1.1
Medication for cholesterol	0.6	0.9	1.1	-0.9	-0.8	-1.1	-1.1	-0.8	-1.0
Arm fat mass (left)	0.6	2.3	4.1	1.3	1.7	1.2	1.4	1.3	2.0
Ever depressed for a whole week	0.6	0.7	1.1	1.0	0.8	0.7	1.0	0.9	0.7
Unable to work because of sickness or disability	0.6	0.8	1.9	0.9	0.2	0.8	0.8	0.8	1.4
Bipolar Disorder or Schizophrenia	0.5	1.2	1.7	-1.1	-1.3	-1.1	-1.2	-1.3	-0.6
Crohns Disease (2017)	0.5	1.2	2.9	-0.6	-0.5	-1.3	-0.6	-1.1	-1.7
Fasting Glucose	0.5	0.6	0.9	-0.9	-0.6	-0.8	-0.8	-0.7	-1.0
Primary Biliary Cirrhosis	0.5	0.7	1.1	-0.8	-0.8	-1.0	-0.9	-0.8	-0.7
Height	0.5	8.8	12.1	3.3	3.5	2.8	3.2	3.4	-0.8
Allergy or Eczema	0.5	1.3	3.4	-1.1	-0.5	-1.8	-1.4	-0.8	-0.6
Hypothyroidism (self reported)	0.5	1.2	1.6	-1.0	-1.1	-1.2	-1.1	-1.3	-0.9
Fed-up feelings	0.5	1.0	2.3	0.8	0.4	1.1	0.8	0.9	1.5
Qualifications: CSEs or equivalent	0.5	0.6	1.1	0.8	0.2	1.1	0.8	0.6	1.0
High blood pressure	0.5	1.5	2.9	-1.4	-0.9	-1.2	-1.1	-1.7	-0.6
Hearing difficulty/problems with background noise	0.5	0.7	1.6	0.9	1.3	0.6	0.8	0.8	0.5
Hip circumference	0.5	2.2	4.2	1.4	2.1	1.1	1.5	1.3	1.3
Happiness	0.5	0.6	1.5	-0.7	-0.5	-0.9	-0.6	-0.7	-1.2
Medication: Lansoprazole	0.5	0.6	1.0	0.8	0.7	0.3	0.8	1.0	0.6
Standing height	0.5	5.3	9.1	2.5	3.0	1.9	2.5	2.5	-0.5
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.2	-0.6	-1.1	-0.7	-0.7	-0.9	-0.2
Exposure to tobacco smoke outside home	0.5	0.6	1.7	0.6	0.2	0.9	0.5	0.7	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.0	-0.9	-0.4	-0.4	-0.7	-0.9	-1.0
Health satisfaction	0.5	0.6	1.4	-0.8	0.1	-1.2	-0.6	-0.7	-0.8
Neck or shoulder pain in last month	0.5	0.6	1.0	-0.9	-0.1	-1.0	-0.7	-0.7	-1.0
Mean time to correctly identify matches	0.5	0.9	1.4	-1.2	-0.4	-1.0	-1.0	-1.1	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	0.9	0.8	0.0	0.9	0.8	0.8	0.8
Hypertension (Self-reported)	0.5	1.5	2.9	-1.4	-1.0	-1.1	-1.1	-1.7	-0.7
Average weekly red wine intake	0.5	0.7	2.0	0.7	0.8	0.3	0.7	0.5	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.0	-0.7	-1.0	-0.5	-0.7	-0.8	0.2
Mineral and other dietary supplements	0.5	0.7	2.4	0.8	1.5	0.4	0.9	0.4	0.4
Neuroticism (Nagel 2018)	0.4	0.8	1.6	-0.8	-0.3	-1.1	-0.6	-1.1	-1.2
Cardiovascular Disease	0.4	1.3	2.7	-1.2	-0.6	-1.3	-1.0	-1.6	-0.8
Number of treatments/medications taken	0.4	0.6	0.9	-0.9	-0.8	-0.8	-0.8	-1.0	-0.4
Relative age of first facial hair	0.4	0.7	1.1	-0.8	-0.1	-1.0	-0.9	-0.9	-1.1
Maternal smoking around birth	0.4	0.6	1.1	-1.1	-0.3	-0.6	-1.0	-0.9	0.7
Medication: Atenolol	0.4	0.5	1.3	-0.8	-1.1	-0.5	-0.6	-0.7	-0.5
Had menopause	0.4	0.6	1.0	0.7	1.0	0.5	0.7	0.8	0.7
Father’s age at death	0.4	0.5	1.0	1.0	0.3	0.8	0.8	0.9	0.3
Breastfed as a baby	0.4	0.5	1.0	0.7	1.0	0.5	0.8	0.5	0.6
Tense / ‘highly strung’	0.4	0.7	1.0	0.9	0.9	0.9	1.0	0.7	0.2
Blood clot in the leg (DVT)	0.4	0.5	0.9	0.5	1.0	0.2	0.4	1.0	0.9
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.8	-0.8	-0.3	-0.9	-0.8	-0.9	-0.1
Medication: Blood pressure	0.4	0.7	1.5	-0.9	-0.8	-0.8	-0.8	-1.2	-0.2
Leg fat mass (right)	0.4	1.4	2.9	0.9	1.3	1.0	1.0	0.9	1.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	0.7	0.4	0.8	0.6	0.7	1.0
Commuting to job workplace: Walk	0.4	0.4	1.2	-0.5	-1.1	-0.4	-0.5	-0.7	-0.5
Average weekly champagne plus white wine intake	0.4	0.5	1.6	0.5	1.2	0.6	0.9	0.4	0.1
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.3	1.3	0.7	1.0	1.0	1.5	0.3
Leg fat mass (left)	0.4	1.5	3.3	0.9	1.4	0.9	1.0	0.9	1.8
Reaction Time	0.3	0.6	0.8	-0.9	-0.5	-0.8	-0.8	-0.9	-0.4
Hand grip strength (left)	0.3	0.7	4.2	0.0	-0.4	-0.1	-0.1	0.0	-2.1
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.7	-0.7	-0.3	-0.9	-0.6	-0.7	-0.7
Trunk fat percentage	0.3	1.4	2.1	-1.4	-0.6	-1.4	-1.3	-1.5	-0.4
Hand grip strength (right)	0.3	0.7	4.1	-0.2	-0.1	-0.2	-0.2	-0.1	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	1.3	-1.0	-1.0	-0.5	-0.8	-1.1	-0.7
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.1	-0.8	-0.2	-1.4	-0.9	-0.6	0.1
Past tobacco smoking	0.3	0.5	1.3	-0.2	-0.7	-0.8	-0.5	-0.4	-1.2
Allergy	0.3	0.7	2.3	0.9	0.1	1.5	0.9	0.6	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.3	0.6	1.1	0.4	0.7	0.7	0.3
Pulse rate	0.3	0.4	2.0	0.5	1.4	-0.3	0.5	0.2	-0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.0	-0.5	-1.0	-0.9	-0.7	-0.9	-0.4
Medication: Amlodipine	0.3	0.4	1.1	0.4	0.1	0.8	0.5	0.3	1.1
High blood pressure (siblings)	0.3	0.4	1.0	-0.5	-0.7	-0.2	-0.6	-0.5	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.6	0.2	0.6	0.4	0.4	0.1	1.3
Number of children fathered	0.3	0.4	1.5	0.3	0.2	0.6	0.3	0.4	1.2
Alcohol intake frequency.	0.3	0.7	3.1	0.7	-0.2	0.2	0.5	0.5	1.8
Mood swings	0.3	0.5	1.3	0.7	0.6	0.5	0.6	0.4	1.1
Loneliness, isolation	0.3	0.4	0.5	-0.5	-0.7	-0.7	-0.5	-0.7	-0.6
Medication: Aspirin	0.3	0.5	0.8	0.5	0.6	0.6	0.7	0.6	0.9
High cholesterol (Self-reported)	0.3	0.5	1.2	-0.5	-0.0	-1.1	-0.3	-0.9	-0.8
Supplements: Calcium	0.3	0.3	1.5	-0.0	-1.2	0.4	-0.2	0.1	-0.1
Pack years of smoking	0.3	0.4	0.8	-0.8	-0.4	-0.6	-0.7	-0.9	-0.3
Depressed Affect (Nagel 2018)	0.2	0.4	0.8	-0.7	-0.1	-0.9	-0.6	-0.9	-0.2
Schizophrenia (2018)	0.2	0.4	0.5	-0.5	-0.4	-0.7	-0.7	-0.7	-0.7
Rheumatoid Arthritis	0.2	0.3	0.9	0.5	0.5	0.6	0.4	0.9	-0.3
Respiratory disease	0.2	0.5	0.8	-0.7	-0.9	-0.9	-0.8	-0.7	-0.2
Chronotype (morning person)	0.2	0.4	1.0	-0.5	-0.4	-0.8	-0.5	-0.4	-1.0
Hair Pigment	0.2	4.5	5.9	1.9	2.4	2.0	2.0	2.4	1.9
Tanning	0.2	2.4	3.7	1.5	1.6	1.6	1.5	1.9	1.1
Sensitivity / hurt feelings	0.2	0.3	0.9	-0.3	-0.4	-0.5	-0.4	-0.5	-0.9
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.4	0.3	0.7	-0.0	0.4	0.5	0.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	0.3	0.7	0.3	0.4	0.6	0.4
Supplements: Glucosamine	0.2	0.2	1.0	-0.3	-1.0	0.3	-0.3	-0.0	-0.4
Alcohol usually taken with meals	0.2	0.4	0.5	0.5	0.7	0.7	0.5	0.6	0.7
Nervous feelings	0.2	0.4	1.7	-0.4	-0.3	-0.4	-0.5	-0.5	-1.3
Medication: Ramipril	0.2	0.2	0.5	-0.7	-0.2	-0.7	-0.5	-0.4	-0.0
Falls in the last year	0.2	0.3	1.8	0.0	-1.4	0.1	-0.2	-0.0	0.4
Number of live births	0.2	0.2	0.5	-0.4	-0.3	-0.6	-0.5	-0.7	-0.2
Loud music exposure frequency	0.2	0.2	0.5	0.2	0.6	0.7	0.2	0.4	0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.6	0.7	0.8	0.5	0.5	0.6	0.5
Body fat percentage	0.2	1.0	1.5	-1.2	-0.5	-1.2	-1.1	-1.2	-0.1
Leg fat percentage (right)	0.2	0.6	1.0	-0.8	-0.6	-0.7	-0.8	-1.0	0.3
Number of full brothers	0.2	0.2	0.7	0.4	0.5	0.8	0.5	0.2	-0.2
Age at first live birth	0.2	0.3	1.3	-0.2	-0.6	-0.4	-0.1	-0.2	-1.1
Whole body fat mass	0.2	0.9	1.8	0.7	1.3	0.6	0.8	0.7	1.4
Pulse rate, automated reading	0.2	0.6	2.6	0.7	1.6	0.1	0.8	0.1	0.2
Chest pain or discomfort	0.2	0.3	0.6	-0.5	0.7	-0.8	-0.2	-0.7	-0.1
Family relationship satisfaction	0.2	0.2	0.3	0.5	0.3	0.5	0.5	0.5	0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.6	0.1	-0.6	-0.4	-0.4	0.1
Qualifications: nursing, teaching	0.2	0.3	0.5	-0.6	-0.4	-0.7	-0.5	-0.5	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.8	0.6	0.9	0.0	0.7	0.5	0.0
Asthma (self-reported)	0.2	0.4	0.7	-0.6	-0.8	-0.8	-0.6	-0.6	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.9	0.3	0.3	0.0	0.3	0.2	-1.4
Miserableness	0.2	0.3	0.6	-0.6	-0.3	-0.6	-0.6	-0.8	-0.4
Hearing aid user	0.2	0.2	0.4	0.5	0.4	0.4	0.5	0.6	0.5
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	-0.4	-0.6	-0.2	-0.5	-0.6	-0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.3	-0.2	-1.1	-0.0	-0.4	0.0	0.5
Leg fat percentage (left)	0.2	0.6	1.0	-0.9	-0.5	-0.6	-0.8	-1.0	0.5
Average weekly beer plus cider intake	0.2	0.3	0.9	0.4	0.5	0.5	0.4	0.2	1.0
Commuting to job workplace: Cycle	0.2	0.3	0.7	0.3	0.9	0.7	0.5	0.4	0.1
Cholesterol lowering medication	0.2	0.2	0.5	0.5	0.1	0.5	0.5	0.3	0.7
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	-0.3	-0.1	-0.5	-0.4	-0.4	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	0.3	0.7	0.0	0.1	0.8	0.7
Irritable Bowel Disease (IBD)	0.1	0.3	0.6	0.8	0.5	-0.2	0.6	0.3	-0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.6	-0.4	-0.3	-0.6	-0.3	-0.7	-0.2
Age at First Birth	0.1	0.2	0.6	-0.4	-0.8	-0.4	-0.5	-0.2	-0.3
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	-0.3	0.1	-0.1	-0.3	-0.2	0.5
Crohns Disease (2012)	0.1	0.1	0.2	0.3	0.4	-0.4	0.3	-0.1	-0.4
Mean Putamen Volume	0.1	0.1	0.2	0.2	0.4	-0.4	0.3	-0.4	0.3
HDL Cholesterol	0.1	0.1	0.6	-0.1	-0.7	-0.1	-0.1	-0.1	-0.2
Neuroticism (2016)	0.1	0.2	0.5	-0.3	-0.7	-0.2	-0.3	-0.5	0.3
Triglycerides	0.1	0.1	0.3	-0.4	-0.2	-0.1	-0.4	-0.6	-0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	0.4	0.3	-0.0	0.2	0.1	-0.3
Blood Eosinophil Count	0.1	0.8	3.7	0.6	0.4	0.0	0.3	0.7	1.9
Waist Hip Ratio (WHR)	0.1	0.5	0.8	0.7	0.7	0.9	0.8	0.4	0.7
Hearing difficulty/problems: Yes	0.1	0.2	0.4	-0.3	-0.5	-0.6	-0.3	-0.6	0.2
Systolic blood pressure, automated reading	0.1	0.2	0.3	-0.3	-0.2	-0.2	-0.3	-0.5	0.6
Medication: Co-codamol	0.1	0.2	0.5	-0.1	0.6	0.1	0.2	0.2	-0.7
Diabetes (father)	0.1	0.1	0.3	-0.1	-0.5	-0.3	-0.2	-0.4	-0.1
Severe depression (siblings)	0.1	0.1	0.2	-0.2	0.1	-0.5	-0.2	-0.2	-0.5
Pack years adult smoking proportion	0.1	0.2	0.5	-0.5	-0.1	-0.5	-0.5	-0.7	0.0
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	0.4	-0.1	0.1	0.3	0.1	0.5
Medication: Levothyroxine sodium	0.1	0.1	0.2	-0.2	-0.5	-0.4	-0.3	-0.4	0.5
Pain all over the body in last month	0.1	0.1	0.1	0.3	0.3	0.1	0.2	0.4	0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	-0.1	0.6	-0.5	-0.1	0.4	-0.2
Medication: Simvastatin	0.1	0.2	0.5	-0.4	0.0	-0.6	-0.1	-0.7	-0.2
Arm fat percentage (right)	0.1	0.2	0.6	-0.4	0.0	-0.4	-0.4	-0.4	0.8
Worrier / anxious feelings	0.1	0.1	0.5	0.2	0.1	-0.1	0.2	-0.4	-0.7
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	0.3	0.6	0.0	0.4	0.4	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.3	-0.4	-0.2	-0.6	-0.4	-0.4	-0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	-0.6	0.1	-0.5	-0.4	-0.3	-0.2
Asthma	0.1	0.2	0.5	-0.4	-0.6	-0.7	-0.5	-0.5	0.1
Depression (self-reported)	0.1	0.2	0.6	-0.2	0.1	-0.8	-0.4	-0.3	-0.1
Prospective memory result	0.1	0.1	0.5	-0.3	-0.0	-0.7	-0.4	-0.2	-0.3
Pulse wave Arterial Stiffness index	0.1	0.2	0.3	0.5	0.4	0.4	0.4	0.2	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.3	0.5	0.0	0.3	0.1	0.3
Hair/balding pattern: Pattern 4	0.1	0.2	0.6	-0.0	-0.8	0.1	0.0	-0.4	-0.6
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.2	-0.3	-0.5	-0.3	-0.3	-0.2
Gout (self-reported)	0.1	0.1	0.5	-0.1	-0.7	0.2	-0.2	-0.1	-0.0
Worry too long after embarrassment	0.1	0.2	0.6	-0.2	-0.2	-0.5	-0.1	-0.6	-0.8
Wheeze or whistling in the chest in last year	0.1	0.1	0.7	0.1	0.3	-0.1	0.0	0.0	0.8
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.2	0.5	-0.5	-0.1	-0.0	0.4
Medication for pain relief, constipation, heartburn	0.1	0.2	0.6	0.2	0.6	-0.3	0.1	0.3	-0.8
Medication: Allopurinol	0.1	0.1	0.3	0.3	-0.2	0.5	0.2	0.4	0.4
Supplements: Vitamin C	0.1	0.1	0.2	-0.2	-0.3	-0.2	-0.3	-0.3	-0.4
Smoking status: Previous	0.1	0.1	0.4	-0.0	0.4	0.4	0.2	0.1	0.6
Arm fat percentage (left)	0.1	0.3	0.4	-0.6	-0.2	-0.5	-0.5	-0.6	0.6
Guilty feelings	0.1	0.2	0.3	-0.5	-0.1	-0.3	-0.4	-0.5	-0.6
Mother’s age at death	0.1	0.1	0.2	0.3	-0.2	0.3	0.3	0.2	-0.4
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.4	0.2	-0.4	-0.3	-0.1	-0.4
Medication: Blood pressure	0.1	0.2	0.4	-0.7	-0.2	-0.5	-0.5	-0.6	-0.3
Diastolic blood pressure, automated reading	0.1	0.3	0.7	-0.4	0.1	-0.7	-0.4	-0.9	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.1	0.1	-0.2	0.3	0.1	-0.1	0.0
Schizophrenia (2014)	0.0	0.0	0.0	0.1	0.0	0.0	0.1	-0.1	-0.2
Systolic Blood Pressure	0.0	0.1	0.3	0.1	0.2	-0.2	0.1	-0.3	0.5
Neuroticism	0.0	0.1	0.2	-0.2	-0.2	-0.4	-0.2	-0.4	-0.3
Supplements: Zinc	0.0	0.0	0.0	-0.2	0.2	-0.2	-0.2	-0.1	-0.1
Trunk fat mass	0.0	0.2	0.6	0.1	0.7	-0.0	0.2	0.0	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	0.0	-0.3	0.1	-0.0	-0.1	-0.2
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	0.1	0.2	-0.0	0.1	-0.1	-0.0
Qualifications: None of the above	0.0	0.1	0.2	-0.3	0.2	0.2	-0.1	-0.0	0.4
Financial difficulties in last 2 years	0.0	0.1	0.1	0.1	-0.2	0.4	0.2	0.0	0.3
Neuroticism score	0.0	0.1	0.1	-0.1	-0.1	-0.3	-0.1	-0.3	-0.2
Medication: Paracetamol	0.0	0.0	0.1	-0.1	-0.3	0.0	-0.2	-0.3	0.2
Headache pain in last month	0.0	0.1	0.3	0.1	-0.1	-0.1	0.2	-0.0	0.6
Pulse wave peak to peak time	0.0	0.1	0.1	-0.3	-0.2	-0.3	-0.2	-0.0	-0.4
Emphysema/chronic bronchitis	0.0	0.0	0.0	-0.2	0.1	0.1	0.0	-0.2	0.2
Medication: Aspirin	0.0	0.0	0.1	-0.2	-0.1	-0.2	-0.0	-0.2	0.2
Friendships satisfaction	0.0	0.0	0.1	-0.0	-0.3	-0.2	-0.1	-0.1	-0.4
Ever taken oral contraceptive pill	0.0	0.0	0.1	-0.1	-0.3	0.0	0.1	-0.1	0.1
Medication: Bendroflumethiazide	0.0	0.0	0.1	0.3	0.0	0.1	0.2	-0.0	0.2
Medication: Paracetamol	0.0	0.0	0.1	0.0	0.0	0.2	-0.1	-0.1	0.3
Medication: Lisinopril	0.0	0.0	0.1	-0.1	0.3	-0.0	0.0	-0.3	0.1

Hub : Genes

OR2AE1

Models

Trait associations