Hub : Genes

ZKSCAN1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0430 0.0240 4.8e-03 0.016 0.016 0.025 0.021 0.014 3.9e-03 3.7e-03 4.5e-04 1.3e-03 7.1e-03
2 GTEx Artery Tibial 0.0672 0.0390 9.0e-03 0.031 NA -0.002 NA 0.005 1.6e-03 NA 5.3e-01 NA 1.2e-01
3 GTEx Cells Transformed fibroblasts 0.2330 0.0690 1.3e-07 0.184 NA 0.175 NA 0.188 8.3e-14 NA 4.2e-13 NA 4.9e-14
4 GTEx Nerve Tibial 0.1033 0.0520 3.4e-03 0.035 NA 0.032 NA 0.042 1.5e-03 NA 2.3e-03 NA 5.5e-04
5 ROSMAP Brain Pre-frontal Cortex 0.0492 0.0218 2.9e-04 0.015 0.031 0.022 0.031 -0.002 4.5e-03 6.1e-05 7.4e-04 7.2e-05 8.9e-01
6 TCGA Skin Cutaneous Melanoma 0.2070 0.1020 1.6e-03 0.031 0.122 0.056 NA 0.113 5.2e-02 3.8e-04 1.3e-02 NA 6.1e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 2.0 3.2 7.2 1.9 1.6 -0.4 2.0 2.7 -1.2
Bipolar Disorder or Schizophrenia 0.9 2.1 3.9 2.0 1.5 -0.3 1.8 1.8 -0.4
Depressed Affect (Nagel 2018) 0.3 0.7 2.6 0.9 0.3 -0.5 0.4 1.6 -0.6
Depression (Nagel 2018) 1.1 1.6 4.2 0.8 1.4 0.2 1.4 2.0 -1.0
Intelligence (Savage-Jansen 2018) 1.4 4.3 7.5 1.7 2.7 1.4 2.5 1.7 -2.2
Neuroticism (Nagel 2018) 0.7 1.7 3.5 0.6 1.3 0.1 1.5 1.6 -1.9
Schizophrenia (2018) 0.2 0.4 1.0 1.0 0.7 -0.1 0.6 0.1 0.5
Schizophrenia vs Biploar Disorder 1.2 1.5 4.1 -0.8 -1.2 0.2 -1.4 -2.0 0.9
Worry (Nagel 2018) 0.4 0.9 2.5 -1.6 -0.7 0.1 -0.5 -1.4 -0.4
Alzheimer’s Disease (in mother) 5.4 6.4 9.4 -1.9 -2.6 -0.9 -3.0 -3.1 2.9
Alzheimer’s Disease (in father) 2.9 3.2 5.2 -2.3 -1.3 -1.8 -1.8 -2.0 1.3
Alzheimer’s Disease (including proxy) 12.0 17.4 30.7 -3.7 -4.4 -1.6 -5.5 -4.6 4.0
Crohns Disease (2017) 0.7 1.5 2.5 0.4 1.6 1.2 1.4 0.9 -1.4
Irritable Bowel Disease (IBD) 0.3 0.6 1.2 0.7 0.9 -0.8 1.1 -0.7 -0.1
Ulcerative Colitis (UC) 0.7 1.4 5.0 0.2 -0.0 -1.7 0.2 -2.2 0.7
Major Depression (MDD) 0.8 1.0 4.7 0.3 0.6 -2.2 0.7 -0.3 0.5
Reaction Time 0.7 1.3 4.7 1.1 0.7 0.3 1.0 2.2 -0.5
Verbal and Numeric Reasoning (VNR) 2.1 5.1 9.3 0.5 2.7 2.3 2.4 1.6 -3.0
Breast Cancer 2.7 6.4 10.7 0.6 2.9 2.8 2.9 1.6 -3.3
Ovarian Cancer 0.6 0.8 2.3 -0.2 0.7 0.1 0.8 1.1 -1.5
Prostate Cancer 1.2 1.7 4.1 -2.0 -1.8 -0.8 -1.6 0.1 0.1
Age at First Birth 0.7 1.1 5.6 -0.8 -0.2 -0.3 -0.3 -2.4 0.1
Bipolar Disorder (2011) 1.1 1.1 1.7 -0.3 1.2 -1.3 1.3 0.8 -1.1
Body Mass Index (BMI) (2010) 0.5 0.7 1.6 0.6 0.8 -0.5 1.0 1.3 -0.4
Coronary Artery Disease (CAD) 2.3 2.7 4.3 1.1 1.9 -0.1 2.1 1.8 -2.0
Crohns Disease (2012) 0.5 0.8 1.9 -1.4 0.3 1.0 0.1 -0.1 -1.4
Mean Putamen Volume 2.7 3.0 5.7 2.1 2.2 0.1 2.4 1.4 -1.3
Fasting Glucose 0.5 0.5 1.6 1.1 0.3 1.2 0.1 0.3 0.5
HbA1C 1.5 1.6 3.8 1.0 -2.0 -0.1 -1.8 -0.5 1.3
HDL Cholesterol 0.7 1.2 2.2 0.5 -1.5 -0.8 -1.2 -0.8 1.5
LDL Cholesterol 0.7 1.2 1.7 0.9 1.3 1.2 1.3 0.9 -0.8
Lupus 0.5 0.8 2.0 -1.1 0.4 -1.0 0.6 0.4 -1.4
Neuroticism (2016) 0.6 0.9 1.8 0.1 1.2 0.2 1.3 1.0 -1.2
Primary Biliary Cirrhosis 1.0 1.4 6.6 -0.1 0.5 2.6 0.4 0.4 -1.0
Rheumatoid Arthritis 4.0 5.5 11.0 -1.9 -2.4 -0.9 -2.6 -3.3 2.1
Schizophrenia (2014) 0.1 0.3 0.6 0.8 0.6 -0.5 0.7 0.2 0.1
Triglycerides 1.5 2.4 3.8 0.6 1.9 0.9 1.8 1.9 -1.5
Type 2 Diabetes (T2D) (2012) 1.8 2.1 4.5 -1.7 -2.1 -0.3 -2.0 -0.2 1.1
Ulcerative Colitis 2.3 3.3 9.3 -0.1 -0.9 -3.1 -0.5 -2.8 1.3
Blood Eosinophil Count 0.1 0.9 3.0 1.7 -0.2 -0.7 0.5 1.3 -0.2
Blood Platelet Count 3.1 35.6 136.9 -3.2 -3.8 -11.7 -3.0 -1.7 6.3
Blood Red Count 4.2 40.3 102.0 -0.6 2.6 5.8 2.9 10.1 -9.5
Blood White Count 0.4 2.6 12.7 0.4 0.2 -1.6 0.6 3.6 -0.1
Heel T-Score 0.5 4.3 13.2 -2.4 0.6 2.1 0.3 1.5 -3.6
BMI 0.9 5.2 21.5 0.7 -0.4 -4.6 0.1 2.6 1.5
Height 0.7 12.9 26.9 1.6 4.8 2.8 4.0 -5.2 -1.1
Waist Hip Ratio (WHR) 1.7 7.6 13.8 0.0 3.7 2.5 3.2 2.2 -3.2
Systolic Blood Pressure 1.1 5.3 11.6 -0.3 2.1 0.1 2.3 3.4 -3.3
Smoking Status 0.8 1.8 7.0 -0.6 1.1 -0.6 1.1 2.6 -0.9
Allergy or Eczema 1.7 4.4 11.4 0.7 -3.4 -1.3 -2.9 -1.0 1.9
Cardiovascular Disease 4.6 15.1 24.7 2.6 4.8 0.5 5.0 4.6 -3.8
Hypothyroidism (self reported) 0.2 0.5 0.9 -0.4 -0.9 0.5 -1.0 -0.8 0.2
Respiratory disease 0.7 1.5 4.0 1.7 -0.6 2.0 -0.4 1.3 0.1
Type 2 Diabetes (T2D) (2018) 1.0 2.0 6.5 0.2 1.1 0.3 1.2 2.6 -1.6
Lung FEV1/FVC ratio 7.3 36.8 57.6 -5.2 -4.3 -7.6 -4.9 -7.4 6.3
Lung FVC 1.5 7.7 15.8 1.6 4.0 2.3 3.9 1.3 -2.5
Neuroticism 0.1 0.1 0.5 0.1 -0.1 -0.2 0.1 0.7 -0.5
Chronotype (morning person) 0.6 1.3 4.3 -0.2 -1.2 -1.0 -1.0 -2.1 0.5
Hair Pigment 0.1 4.0 8.9 -0.6 -1.9 -1.4 -2.1 -2.1 3.0
Tanning 0.1 1.0 2.9 0.5 0.3 -1.0 0.2 -1.3 1.7
Hand grip strength (left) 1.8 4.8 9.8 0.9 3.1 1.8 2.5 -3.0 -0.5
Number of treatments/medications taken 0.6 1.0 5.1 0.5 -0.0 0.1 0.2 2.3 -0.9
Average weekly spirits intake 0.4 0.5 1.3 -1.1 -0.2 -1.1 -0.0 0.5 -0.6
Sensitivity / hurt feelings 0.2 0.4 0.8 0.8 -0.1 -0.9 -0.0 0.1 0.8
Frequency of depressed mood in last 2 weeks 0.0 0.1 0.3 0.2 0.1 0.0 0.1 0.5 0.1
Hearing difficulty/problems: Yes 0.5 0.7 1.3 0.9 1.1 -0.4 1.1 0.8 -0.4
Relative age of first facial hair 0.7 1.5 3.4 1.2 1.9 -0.8 1.8 -0.4 -0.1
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 2.1 -1.4 -1.3 0.5 -1.0 -0.0 -1.1
Ever used hormone-replacement therapy (HRT) 1.3 1.7 2.4 -1.4 -0.9 -1.6 -0.9 -1.4 1.5
Ever had hysterectomy (womb removed) 1.1 1.2 1.8 -0.8 -1.2 -0.4 -1.3 -1.3 1.2
Systolic blood pressure, automated reading 0.7 1.9 5.0 -0.7 1.0 0.3 1.1 2.2 -2.0
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.9 -0.5 0.0 -0.9 0.1 0.0 -0.3
Angina 1.0 1.3 6.0 0.6 -0.4 0.6 -0.0 2.4 -0.8
Medication for hormone replacement therapy 0.3 0.4 1.4 -1.2 0.4 -0.2 0.3 -0.1 -0.7
Vitamin and mineral supplements 1.6 2.2 4.0 0.9 2.0 1.3 1.8 1.6 -1.1
Supplements: Zinc 0.6 0.7 2.8 1.7 0.4 -0.4 0.6 0.5 0.6
Medication: Co-codamol 0.2 0.3 0.8 0.9 -0.3 -0.3 0.1 0.8 0.0
Medication: Metformin 0.2 0.3 0.7 0.8 0.3 -0.6 0.4 0.8 0.3
Diabetes (father) 0.3 0.3 1.1 -0.9 0.1 0.2 0.2 0.2 -1.0
Diabetes (mother) 0.3 0.4 0.9 -0.7 -0.1 -1.0 0.1 0.9 -0.4
Severe depression (siblings) 0.1 0.1 0.2 0.3 0.4 0.1 0.4 0.5 -0.3
Pack years adult smoking proportion 2.2 3.4 8.6 1.7 1.7 -0.8 2.0 2.9 -1.2
Impedance of leg (right) 2.6 12.7 23.2 1.3 3.6 4.8 3.5 2.1 -4.7
Leg fat-free mass (left) 0.8 4.1 10.5 0.5 -0.4 -3.2 -0.5 -2.1 3.0
Trunk fat percentage 1.2 4.7 11.5 3.4 1.7 -0.8 2.0 3.0 0.0
Hand grip strength (right) 1.8 4.9 10.4 0.8 3.2 2.4 2.7 -2.1 -1.1
Townsend deprivation index at recruitment 1.1 1.5 2.7 0.2 1.5 0.1 1.7 1.6 -1.2
Current tobacco smoking 0.5 0.8 2.3 -1.4 -0.5 0.1 -0.5 1.5 -0.3
Average weekly fortified wine intake 0.2 0.2 0.4 -0.5 -0.5 0.4 -0.7 0.2 -0.2
Maternal smoking around birth 0.8 1.1 3.8 0.2 0.8 -0.8 1.1 1.9 -0.6
Fed-up feelings 1.8 3.3 8.6 -0.5 -2.0 -2.9 -1.8 -0.0 1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.9 0.4 0.1 -1.0 0.2 1.4 -0.0
Relative age voice broke 1.3 1.9 5.4 2.3 1.2 -1.4 1.4 -0.5 0.6
Taking other prescription medications 0.6 0.9 2.4 0.4 -0.6 1.5 -0.4 1.3 -1.0
Age when periods started (menarche) 3.4 8.2 17.5 3.7 4.0 -0.7 4.2 0.7 -0.9
Bilateral oophorectomy (both ovaries removed) 1.5 1.7 4.9 -1.2 -0.9 -2.2 -0.8 -1.2 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 3.6 -0.8 0.6 0.9 0.5 1.0 -1.9
Tinnitus: Yes, but not now, but have in the past 2.9 3.1 5.9 0.3 -2.4 -2.3 -2.0 -0.2 1.9
Qualifications: CSEs or equivalent 1.6 2.1 3.4 -0.9 -1.7 -1.5 -1.7 -0.5 1.8
Serious illness, injury or assault to yourself 0.3 0.4 1.1 -0.0 -0.8 -1.1 -0.4 -0.1 0.6
High blood pressure 5.7 15.8 25.0 2.6 4.7 1.3 5.0 4.8 -4.0
Hayfever, allergic rhinitis or eczema 1.8 4.0 9.2 0.6 -3.0 -1.7 -2.6 -0.7 2.1
Multivitamins +/- minerals 1.8 2.3 4.0 -0.4 -1.7 -2.0 -1.5 -1.6 1.3
Stomach or abdominal pain in last month 1.8 2.2 5.6 -1.2 -2.4 0.2 -2.3 0.1 0.8
Supplements: Glucosamine 3.9 5.1 10.2 0.9 -2.1 -1.9 -2.0 -3.2 2.7
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.8 -1.3 -0.8 -0.4 -1.0 -1.1 0.3
Medication: Atenolol 1.9 2.4 4.4 1.7 1.9 0.3 2.1 1.5 -0.9
Medication: Levothyroxine sodium 0.8 1.3 2.2 -1.1 -1.5 -0.7 -1.5 -1.2 0.4
Sitting height 0.9 6.5 29.7 -1.6 -1.0 0.3 -1.6 -5.5 1.8
Chronic bronchitis/emphysema (father) 0.7 0.9 1.8 0.2 1.2 0.4 1.1 1.4 -0.8
High blood pressure (mother) 0.6 0.8 3.8 1.9 -0.1 -0.4 0.0 0.1 1.0
Body mass index (BMI) 0.9 3.6 14.9 0.8 -0.2 -3.9 0.0 1.7 1.9
Impedance of leg (left) 2.6 12.6 23.4 1.3 3.5 4.8 3.4 2.3 -4.6
Leg predicted mass (left) 0.8 4.1 10.6 0.5 -0.4 -3.3 -0.4 -2.0 3.0
Trunk fat mass 0.8 3.2 7.7 2.8 1.6 -1.4 1.8 1.9 0.5
Waist circumference 0.4 1.5 2.9 1.1 1.0 -1.6 0.9 1.7 0.8
Number of incorrect matches in round 0.2 0.3 0.8 0.1 0.9 -0.1 0.7 -0.4 -0.7
Past tobacco smoking 1.9 3.6 6.8 0.1 -2.2 0.0 -2.3 -2.6 2.1
Alcohol usually taken with meals 0.1 0.1 0.4 -0.2 -0.3 0.6 -0.3 -0.4 0.1
Nervous feelings 0.2 0.3 1.3 -0.1 0.3 1.1 0.4 -0.0 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.4 -0.0 0.2 0.2 -0.2 -1.2 0.6
Hearing difficulty/problems with background noise 0.8 1.3 1.9 1.2 1.3 0.7 1.3 1.4 -0.9
Hair/balding pattern: Pattern 2 0.8 1.1 3.0 -0.1 1.3 -0.4 1.3 0.0 -1.7
Had menopause 0.6 0.8 2.3 -0.2 -0.1 -0.8 -0.2 -1.5 1.3
Had other major operations 5.3 6.5 10.9 -1.4 -3.0 -3.3 -2.7 -1.2 2.8
Forced vital capacity (FVC) 0.6 2.1 4.4 0.6 2.1 1.1 1.7 -2.0 0.2
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.5 5.8 -0.1 1.4 1.5 1.3 1.7 -2.4
Ever unenthusiastic/disinterested for a whole week 0.8 0.9 2.8 -1.7 -0.1 -1.2 -0.1 -1.2 0.1
Qualifications: None of the above 0.3 0.7 3.0 0.2 -0.3 -1.7 -0.1 0.6 0.9
Financial difficulties in last 2 years 0.2 0.2 0.6 -0.1 -0.5 -0.2 -0.5 0.8 0.5
Mouth/teeth dental problems 1.1 1.7 5.7 2.4 1.2 -0.4 1.3 -0.2 1.1
Heart attack 0.6 0.8 3.2 0.7 -0.2 1.8 -0.1 1.1 -0.1
Allergy 2.1 4.7 11.4 -1.2 3.4 0.5 3.0 -0.0 -2.5
Pain all over the body in last month 0.8 0.9 2.3 1.1 0.4 -1.5 0.5 -0.5 1.0
Diabetes (self-reported) 0.6 0.9 2.6 -0.7 0.5 -0.5 0.6 1.6 -1.1
Hayfever/allergic rhinitis (self-reported) 4.2 5.6 10.5 -0.8 -3.2 -1.2 -3.1 -2.2 2.5
Medication: Ramipril 0.9 1.1 5.4 2.3 0.0 0.0 0.2 0.8 0.9
Medication: Simvastatin 4.0 5.9 9.6 1.1 3.1 0.5 3.0 2.8 -2.7
Fluid intelligence score 2.3 4.7 9.4 0.3 2.5 2.4 2.2 1.4 -3.1
Illnesses of siblings 3.1 4.3 7.2 -1.7 -2.7 -2.0 -2.7 -1.2 1.7
Neuroticism score 0.1 0.2 1.0 0.5 -0.0 -0.1 0.2 1.0 -0.2
Weight 0.4 1.9 5.6 1.3 0.9 -2.4 0.9 -0.2 1.7
Impedance of arm (right) 2.1 9.8 21.7 2.8 2.5 4.7 2.5 2.5 -3.3
Arm fat percentage (right) 0.8 3.1 6.7 2.4 0.3 -2.1 0.7 2.6 1.3
Trunk fat-free mass 0.8 4.4 13.2 -0.8 -0.3 -2.3 -0.7 -3.6 2.7
Hip circumference 0.5 2.1 5.2 1.6 -0.2 -2.1 -0.1 0.4 2.3
Time employed in main current job 0.3 0.4 1.2 0.2 -0.0 0.5 0.2 0.9 -1.1
Alcohol intake versus 10 years previously 0.7 1.0 5.2 0.2 -0.2 -0.9 0.1 2.3 -0.2
Father’s age at death 5.2 7.0 10.0 -0.5 -2.9 -2.7 -2.9 -2.8 3.2
Worrier / anxious feelings 0.1 0.1 0.3 0.2 0.4 0.0 0.5 0.2 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 2.3 -0.5 -1.5 -1.2 -1.5 -0.5 1.3
Falls in the last year 1.6 2.2 4.0 -2.0 -1.1 -1.4 -1.2 -2.0 0.8
Hair/balding pattern: Pattern 3 1.2 1.8 3.0 0.0 -1.5 1.2 -1.7 -1.3 1.6
Number of live births 1.3 1.9 4.6 0.8 1.2 2.2 1.0 1.6 -0.9
Forced expiratory volume in 1-second (FEV1) 1.4 4.6 18.1 -1.4 0.3 -1.7 -0.2 -4.3 2.2
Pulse rate 4.0 6.7 13.8 1.4 3.5 -0.7 3.7 2.7 -2.0
Happiness 0.9 1.1 2.6 -0.4 -1.6 0.3 -1.6 -0.3 1.1
Noisy workplace 1.7 2.1 6.4 -0.5 -0.8 -2.5 -0.7 -1.4 1.7
Qualifications: A levels/AS levels or equivalent 0.7 1.6 4.9 -1.1 0.7 2.2 0.3 -0.4 -1.7
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.3 3.1 -0.3 -1.5 1.8 -1.6 0.4 -0.2
Mouth/teeth dental problems: Dentures 0.6 1.0 3.4 -1.8 -1.0 -0.4 -1.1 0.5 -0.4
Asthma 0.7 1.3 3.2 1.8 -0.2 1.6 0.0 1.5 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.5 0.3 -0.6 0.5 -0.7 0.3 0.6
Medication: Cholesterol lowering 6.3 9.8 16.4 2.8 3.5 0.5 3.8 4.1 -2.7
Depression (self-reported) 0.4 0.5 2.3 -0.5 0.2 -1.5 0.3 -0.5 -0.0
Medication: Lansoprazole 0.4 0.4 1.0 -1.0 -0.4 0.1 -0.4 -1.0 -0.5
Prospective memory result 0.1 0.1 0.3 -0.2 -0.2 -0.5 -0.3 0.2 0.3
Lung cancer (father) 2.2 2.6 4.6 -0.5 -1.5 -2.1 -1.2 -2.0 1.8
Illnesses of mother 1.3 1.6 4.5 -2.1 -1.3 0.7 -1.5 -0.9 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.2 17.6 -1.9 0.4 -1.3 -0.2 -4.2 1.4
Pulse wave Arterial Stiffness index 0.9 1.1 2.1 -0.9 1.1 -0.3 1.1 1.0 -1.5
Impedance of arm (left) 2.5 11.7 29.3 3.1 2.6 5.4 2.6 2.5 -3.4
Arm fat mass (right) 0.6 2.6 7.2 1.6 0.4 -2.7 0.6 1.4 1.7
Trunk predicted mass 0.8 4.5 13.0 -0.8 -0.4 -2.3 -0.7 -3.6 2.7
Standing height 0.6 5.5 13.6 1.2 2.5 2.9 1.9 -3.7 -0.4
Length of working week for main job 0.4 0.4 1.1 -1.1 0.5 0.2 0.5 -0.5 -0.8
Exposure to tobacco smoke at home 0.2 0.2 0.8 -0.9 -0.2 -0.3 -0.2 -0.5 0.1
Breastfed as a baby 0.4 0.4 1.1 0.4 -0.8 -0.1 -0.8 1.0 0.4
Tense / ‘highly strung’ 0.0 0.1 0.1 -0.2 0.4 0.1 0.4 -0.4 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.7 -1.3 0.4 -0.8 0.3 0.1 -0.5
Hair/balding pattern: Pattern 4 0.6 1.5 1.9 -0.7 -1.4 -1.3 -1.4 -1.2 1.3
Birth weight of first child 2.7 4.9 23.7 -1.5 1.0 -1.3 0.5 -4.9 0.7
Peak expiratory flow (PEF) 3.3 7.6 20.5 -1.3 -1.5 -2.9 -1.8 -4.5 3.0
Pulse wave reflection index 0.4 0.4 1.2 -0.7 0.8 0.1 0.6 -0.1 -1.1
Ever highly irritable/argumentative for 2 days 0.7 0.9 1.7 0.8 1.2 -0.5 1.3 1.1 -0.3
Loud music exposure frequency 0.4 0.4 1.0 0.1 0.7 0.1 0.8 1.0 -0.6
Qualifications: O levels/GCSEs or equivalent 1.6 2.5 4.8 -0.6 2.0 1.3 1.8 1.0 -2.2
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.3 -0.7 -1.1 0.0 -1.1 -0.8 0.3
Blood clot in the leg (DVT) 0.9 1.2 3.0 -0.1 -1.2 0.1 -1.4 -0.8 1.7
Medication: Paracetamol 0.4 0.6 2.1 -0.3 -0.5 -1.2 -0.4 1.4 0.1
Headache pain in last month 0.1 0.3 0.6 -0.4 -0.7 0.2 -0.8 0.2 0.3
Medication for cholesterol, blood pressure or diabetes 7.0 11.7 20.5 -3.6 -3.6 -0.5 -4.2 -4.5 2.5
Glaucoma (self-reported) 0.1 0.1 0.3 -0.5 0.3 0.1 0.3 0.3 -0.4
Gout (self-reported) 0.7 1.0 2.2 1.2 0.9 -1.5 0.9 0.4 0.8
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.8 -0.4 -0.7 0.6 -0.9 -0.9 0.1
Medication: Amlodipine 0.8 1.1 2.8 0.1 1.1 -0.1 1.3 1.7 -1.0
Medication: Ventolin 100micrograms inhaler 3.2 4.1 6.1 2.5 1.7 1.8 2.0 2.4 -1.6
Birth weight 1.3 2.9 8.3 2.9 1.9 -0.8 2.0 -0.4 0.5
Chronic bronchitis/emphysema (mother) 3.4 3.9 9.8 3.1 1.7 -0.5 2.3 2.2 -0.8
High blood pressure (siblings) 1.5 2.2 4.6 0.8 2.1 1.4 2.0 -0.7 -1.1
Forced vital capacity (FVC), Best measure 0.6 2.3 4.7 -0.1 2.1 1.0 1.8 -2.2 -0.5
Body fat percentage 1.2 4.6 10.3 3.1 1.6 -1.1 2.0 3.2 0.1
Leg fat percentage (right) 1.1 4.0 10.3 1.9 1.9 -1.2 2.2 3.2 -0.7
Arm fat-free mass (right) 0.7 3.7 8.0 -0.6 -0.0 -2.8 -0.3 -2.8 2.4
Exposure to tobacco smoke outside home 0.2 0.2 0.9 0.0 0.3 -1.0 0.4 0.4 0.3
Comparative body size at age 10 0.1 0.4 1.6 -0.6 0.2 -0.2 0.1 -1.3 -0.6
Number of full brothers 0.6 0.8 1.2 1.0 0.9 1.1 1.0 0.8 -0.4
Worry too long after embarrassment 1.1 1.8 3.0 1.0 1.6 0.6 1.7 1.3 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 1.9 0.1 1.2 -1.3 1.4 0.8 -0.8
Wheeze or whistling in the chest in last year 0.7 1.3 2.7 0.1 -1.2 -1.5 -0.9 1.6 0.8
Number of children fathered 0.3 0.4 0.9 -0.4 -1.0 -0.6 -0.8 0.4 0.2
Reason for reducing amount of alcohol drunk: Health precaution 3.8 4.4 7.1 2.0 2.1 2.7 2.1 1.6 -2.0
Age at first live birth 0.8 1.3 4.6 -0.9 -1.0 -0.3 -1.2 -2.1 0.1
Pulse wave peak to peak time 0.8 0.9 1.6 0.9 -0.8 0.6 -0.8 -1.2 1.3
Health satisfaction 0.2 0.3 1.3 0.5 -0.3 -0.3 -0.1 1.1 -0.3
Shortness of breath walking on level ground 0.4 0.5 1.3 1.1 0.0 -0.5 0.4 1.2 -0.1
Qualifications: College or University degree 1.6 4.9 12.0 0.1 1.8 3.5 1.6 0.6 -3.4
Eye problems/disorders: None of the above 1.0 1.2 3.3 -1.8 -0.6 -0.5 -1.0 -1.3 0.6
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.7 0.1 0.5 0.6 0.4 0.8 -0.2
Emphysema/chronic bronchitis 1.3 1.4 3.7 1.9 0.9 -0.8 1.2 1.3 0.3
Medication for pain relief, constipation, heartburn 0.3 0.5 1.5 0.2 1.0 0.1 0.8 -1.2 -0.3
Neck or shoulder pain in last month 2.7 3.9 8.4 0.4 -2.9 -0.4 -2.9 -0.0 2.5
Medication: Blood pressure 4.9 8.7 15.1 2.8 3.1 -0.0 3.7 3.9 -2.5
Angina (self-reported) 0.9 1.2 5.8 0.6 -0.4 0.6 -0.0 2.4 -0.9
Migraine (self-reported) 1.6 2.0 3.1 -0.8 -1.4 -1.1 -1.6 -1.8 1.6
Medication: Ibuprofen 0.5 0.6 1.2 0.7 -0.9 0.5 -0.9 0.2 1.1
Medication: Allopurinol 0.8 1.1 2.0 1.3 1.1 -1.4 1.2 0.4 0.3
Medication: Omeprazole 0.7 0.9 4.3 -0.7 -0.4 -2.1 -0.3 0.0 0.4
Medication: Seretide 50 evohaler 0.9 1.0 3.0 1.7 0.3 -0.0 0.8 1.5 -0.1
Mean time to correctly identify matches 1.2 2.3 7.0 1.5 0.9 1.2 1.2 2.6 -0.9
Heart disease (mother) 1.8 2.1 3.0 1.6 1.2 1.7 1.3 1.7 -1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 1.4 -0.8 -1.1 -0.9 -1.1 -1.1 1.2
Whole body fat mass 0.7 3.1 5.3 2.3 1.4 -2.0 1.6 2.0 0.8
Leg fat mass (right) 0.7 2.7 5.5 1.5 1.4 -2.3 1.6 1.8 0.4
Arm predicted mass (right) 0.7 3.4 7.2 -0.5 -0.1 -2.7 -0.3 -2.6 2.4
Pulse rate, automated reading 6.2 20.0 46.9 1.8 6.8 -1.1 6.8 3.1 -3.6
Alcohol intake frequency. 2.2 5.1 13.5 -1.5 -2.6 -3.7 -2.2 -0.7 1.6
Comparative height size at age 10 0.1 0.4 1.6 -0.3 -0.2 0.5 -0.5 -1.2 0.6
Number of full sisters 2.5 3.0 5.9 1.2 2.0 1.0 2.0 2.4 -1.2
Suffer from ‘nerves’ 0.9 1.5 3.0 -1.1 -1.2 -0.9 -1.0 -1.7 1.1
Overall health rating 0.7 1.6 2.5 -1.5 -1.6 -1.5 -1.4 -0.2 0.5
Chest pain or discomfort 1.1 1.5 8.0 0.8 -0.7 -0.0 -0.2 2.8 -0.4
Had major operations 0.5 0.6 1.2 -0.2 -1.1 -0.8 -0.9 -0.8 -0.0
Age at last live birth 0.2 0.3 0.8 0.4 0.3 0.8 0.4 0.0 -0.9
Family relationship satisfaction 0.4 0.5 1.7 -1.3 0.2 0.8 -0.0 -0.0 -0.6
Leg pain on walking 2.3 2.9 6.4 -0.5 -2.5 -0.9 -2.5 -0.1 1.9
Qualifications: NVQ or HND or HNC or equivalent 1.8 2.1 3.3 -0.9 -1.8 -1.4 -1.8 -0.7 1.8
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.0 -0.7 -0.8 0.3 -1.0 0.1 0.2
Illness, injury, bereavement, stress in last 2 years 1.9 2.3 3.7 1.7 1.9 1.6 1.9 0.5 -1.0
Medication: Aspirin 0.2 0.3 1.3 -0.1 0.2 0.4 0.2 1.1 -0.4
Supplements: Vitamin C 2.5 3.0 7.3 -0.3 -2.7 -0.6 -2.4 -1.0 1.8
Knee pain experienced in last month 2.9 4.4 9.1 -1.2 -2.5 -3.0 -2.2 -1.2 1.9
Hypertension (Self-reported) 5.5 15.2 24.7 2.7 4.7 1.4 5.0 4.6 -3.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.2 2.6 5.0 -1.9 -2.1 -0.3 -2.2 -1.2 1.1
Illnesses of father: Heart disease 2.4 3.3 5.9 0.6 2.4 1.9 2.3 1.2 -1.9
Illnesses of siblings: Diabetes 0.8 0.9 2.0 -1.0 -1.4 0.1 -1.3 -0.9 0.3
Smoking status: Previous 2.0 3.0 5.6 0.6 2.3 -0.3 2.4 1.8 -1.8
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 2.7 -0.3 0.2 -0.5 0.0 -1.6 0.8
Whole body fat-free mass 0.7 4.0 8.6 -0.3 -0.3 -2.7 -0.5 -2.9 2.8
Leg fat-free mass (right) 0.8 4.5 10.8 0.3 -0.7 -3.3 -0.8 -2.2 3.2
Arm fat percentage (left) 0.9 3.4 7.3 2.6 0.4 -2.0 0.7 2.7 1.2
Average weekly red wine intake 1.4 2.0 4.9 -1.4 1.7 -0.1 1.5 -0.0 -2.2
Handedness (chirality/laterality): Left-handed 1.3 1.6 4.3 -2.1 1.3 0.8 1.0 -0.2 -1.3
Mood swings 0.2 0.4 1.3 0.5 0.2 -1.1 0.4 0.7 0.2
Loneliness, isolation 0.6 0.8 1.5 -0.8 -1.2 -0.6 -1.2 0.9 0.5
Long-standing illness, disability or infirmity 0.6 0.9 1.7 -0.6 -1.3 0.5 -1.0 0.9 -1.2
Ever had bowel cancer screening 0.5 0.6 1.4 1.2 0.7 -1.0 0.7 -0.3 0.2
Diabetes diagnosed by doctor 0.7 1.1 2.6 -0.8 0.8 -0.5 0.8 1.6 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 3.8 2.0 0.2 0.3 0.5 0.8 0.2
Friendships satisfaction 0.8 1.0 2.3 -0.8 -1.4 -0.0 -1.5 -0.9 0.6
Qualifications: nursing, teaching 0.9 1.4 2.8 0.1 1.5 1.7 1.1 -0.1 -1.5
Commuting to job workplace: Walk 1.0 1.1 2.2 1.4 1.2 -0.5 1.5 0.1 -0.7
Eye problems/disorders: Cataract 4.8 5.5 14.5 3.8 2.0 1.0 2.5 2.5 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 2.1 -0.9 -0.5 0.8 -0.5 0.6 -1.4
Medication for cholesterol 2.0 3.1 6.4 0.2 -2.5 0.0 -2.3 -1.2 2.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 5.1 0.7 -1.6 0.0 -1.4 -1.3 2.3
Back pain experienced in last month 2.0 3.0 6.7 -1.4 -2.6 -0.6 -2.4 -1.2 1.2
Mineral and other dietary supplements 2.9 3.9 6.7 0.5 2.6 1.1 2.4 2.5 -1.8
Breast cancer (self-reported) 4.2 5.0 14.7 0.4 -2.4 -0.9 -2.3 -1.8 3.8
Asthma (self-reported) 0.7 1.4 3.8 1.9 -0.0 1.5 0.2 1.6 -0.1
Osteoporosis (self-reported) 0.3 0.4 1.4 0.9 0.1 0.4 0.4 1.2 -0.2
Osteoarthritis (self-reported) 2.7 3.5 6.6 -1.1 -2.5 -0.7 -2.6 -1.6 2.0
Medication: Aspirin 0.1 0.2 0.5 -0.4 -0.1 0.1 -0.0 0.7 -0.4
Medication: Gliclazide 0.8 0.8 1.4 -1.1 -1.2 -0.5 -1.2 -0.7 0.5
Illnesses of father: None of the above (group 1) 4.5 5.5 10.0 -0.8 -3.2 -2.6 -2.7 -1.3 2.5
Smoking status: Current 0.6 0.9 2.3 -1.5 -0.9 0.3 -1.0 1.1 0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 3.6 0.5 0.3 -0.2 -0.1 -1.5 1.9
Whole body water mass 0.8 4.5 9.6 -0.4 -0.4 -2.9 -0.6 -3.1 3.0
Leg predicted mass (right) 0.8 4.5 10.7 0.4 -0.7 -3.3 -0.8 -2.1 3.3
Arm fat mass (left) 0.6 2.7 7.5 1.7 0.4 -2.7 0.6 1.5 1.7
Number of self-reported non-cancer illnesses 0.6 1.0 2.6 -0.4 0.4 0.8 0.7 1.3 -1.6
Average weekly champagne plus white wine intake 0.2 0.3 0.9 0.9 0.6 0.1 0.5 -0.0 -0.0
Miserableness 0.5 0.9 1.9 -0.5 0.8 0.6 0.6 1.3 -1.4
Guilty feelings 1.0 1.6 4.4 -1.3 1.0 0.8 0.9 1.0 -2.1
Wears glasses or contact lenses 0.4 0.5 1.0 0.3 0.5 0.8 0.3 0.8 -1.0
Ever taken oral contraceptive pill 0.6 0.6 1.1 -0.4 -0.9 1.1 -1.1 0.4 0.5
Hearing aid user 2.3 2.6 4.7 -0.9 -1.9 -2.2 -1.7 -1.1 1.4
Mother’s age at death 2.6 3.3 6.8 -0.1 -2.0 0.9 -2.2 -2.6 1.8
Financial situation satisfaction 0.4 0.4 1.1 -0.2 -0.6 -0.6 -0.7 -0.6 1.0
Tinnitus: Yes, now most or all of the time 0.9 1.0 1.8 0.6 1.4 0.3 1.3 0.7 -1.2
Commuting to job workplace: Public transport 0.3 0.4 1.0 -0.1 -1.0 0.3 -0.7 0.8 -0.0
Eye problems/disorders: Glaucoma 0.3 0.3 1.4 -0.4 0.1 0.2 0.2 1.2 -0.5
Medication: Blood pressure 2.9 5.4 8.2 0.6 2.9 1.8 2.7 2.5 -2.8
Pain type(s) experienced in last month: Hip pain 0.9 1.1 2.0 -1.1 -1.4 -0.9 -1.2 0.9 -0.2
Supplements: Fish oil (including cod liver oil) 1.9 2.5 6.0 -0.2 -1.8 -1.0 -1.6 -2.5 1.5
High cholesterol (Self-reported) 2.9 5.2 10.7 0.6 2.9 0.5 2.9 1.8 -3.3
Medication: Bendroflumethiazide 1.1 1.6 2.8 -0.0 1.7 -0.1 1.7 1.3 -1.6
Medication: Paracetamol 0.6 1.0 2.2 -0.2 -1.0 -1.3 -0.8 1.5 0.6
Medication: Lisinopril 2.6 3.3 6.1 1.5 2.4 -0.3 2.5 2.1 -1.2
Medication: Atorvastatin 2.5 3.1 4.1 1.6 1.8 1.8 2.0 1.2 -2.0
Illnesses of father: High blood pressure 1.5 1.9 4.5 0.6 2.1 0.3 1.9 0.8 -1.4
Alcohol drinker status: Never 0.7 0.9 2.7 -0.0 -1.6 0.3 -1.4 -0.4 0.3
Ever smoked 1.2 2.2 5.9 -1.3 1.1 0.0 1.1 2.4 -1.7
Basal metabolic rate 0.6 3.3 7.5 0.2 0.0 -2.7 -0.1 -2.3 2.6
Leg fat percentage (left) 1.0 3.7 10.5 1.8 1.7 -1.3 1.9 3.2 -0.4
Arm fat-free mass (left) 0.7 3.7 9.1 -0.7 -0.1 -3.0 -0.3 -2.6 2.5
Number of operations (self-reported) 1.7 2.5 3.5 -1.6 -1.9 -1.7 -1.6 -1.6 1.0
Average weekly beer plus cider intake 1.7 2.4 6.2 -0.7 1.0 1.3 1.0 2.5 -2.1
Irritability 2.6 4.4 9.0 2.1 1.9 0.6 2.2 3.0 -1.9
Risk taking 0.8 1.1 2.1 -0.8 -0.9 1.0 -1.1 -1.5 1.1
Ever had prostate specific antigen (PSA) test 0.7 0.8 2.0 0.8 0.7 1.4 0.7 -0.0 -1.0
Fractured/broken bones in last 5 years 1.3 1.7 6.4 -1.4 -0.8 -0.5 -0.9 -2.5 0.7
Age started oral contraceptive pill 1.0 1.3 2.8 0.9 0.9 1.7 0.9 1.0 -1.2
Diastolic blood pressure, automated reading 5.6 17.4 31.7 1.5 5.6 1.6 5.6 4.0 -4.5
Ever depressed for a whole week 0.0 0.0 0.1 -0.3 -0.0 0.1 -0.0 -0.3 0.2
Unable to work because of sickness or disability 1.2 1.6 5.6 -0.2 -0.9 -2.4 -0.7 -0.9 1.4
Commuting to job workplace: Cycle 0.1 0.1 0.3 0.4 -0.5 0.1 -0.3 -0.3 0.2
Myopia 0.9 1.3 3.0 0.3 1.7 -0.0 1.7 -0.4 -1.3
Vascular/heart problems diagnosed by doctor 4.6 12.6 23.6 -2.6 -3.9 -1.0 -4.3 -4.9 3.3
Cholesterol lowering medication 2.3 3.4 7.4 -0.5 2.6 0.5 2.4 0.2 -2.7
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.5 -1.1 -0.6 -1.2 -0.5 0.0 0.2
Pain experienced in last month 1.7 2.9 5.4 0.7 2.3 1.4 2.3 0.9 -1.8
Supplements: Calcium 2.9 3.2 9.4 -0.8 -1.3 -1.3 -1.4 -3.1 2.0
Basal cell carcinoma (self-reported) 0.2 0.3 0.8 0.7 0.4 0.0 0.3 0.9 0.2
Heart attack/myocardial infarction (self-reported) 0.6 0.7 3.1 0.7 -0.0 1.8 0.0 0.9 -0.2
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 3.8 -0.2 -1.6 0.4 -1.7 -1.1 1.9
Heart disease (siblings) 6.4 7.9 12.8 3.0 3.5 1.6 3.6 2.9 -1.6
Alcohol drinker status: Previous 1.2 1.4 3.7 -1.9 0.4 -1.9 0.3 -0.2 -0.8
Pack years of smoking 2.5 3.7 8.9 1.9 1.8 -0.8 2.2 3.0 -1.1
Impedance of whole body 2.5 12.8 28.2 2.4 3.1 5.3 3.1 2.6 -4.2
Leg fat mass (left) 0.7 2.7 5.7 1.6 1.3 -2.4 1.5 2.0 0.6
Arm predicted mass (left) 0.8 4.0 9.3 -0.7 -0.3 -3.0 -0.5 -2.6 2.6