TWAS hub - ZKSCAN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0430	0.0240	4.8e-03	0.016	0.016	0.025	0.021	0.014	3.9e-03	3.7e-03	4.5e-04	1.3e-03	7.1e-03
2	GTEx	Artery Tibial	0.0672	0.0390	9.0e-03	0.031	NA	-0.002	NA	0.005	1.6e-03	NA	5.3e-01	NA	1.2e-01
3	GTEx	Cells Transformed fibroblasts	0.2330	0.0690	1.3e-07	0.184	NA	0.175	NA	0.188	8.3e-14	NA	4.2e-13	NA	4.9e-14
4	GTEx	Nerve Tibial	0.1033	0.0520	3.4e-03	0.035	NA	0.032	NA	0.042	1.5e-03	NA	2.3e-03	NA	5.5e-04
5	ROSMAP	Brain Pre-frontal Cortex	0.0492	0.0218	2.9e-04	0.015	0.031	0.022	0.031	-0.002	4.5e-03	6.1e-05	7.4e-04	7.2e-05	8.9e-01
6	TCGA	Skin Cutaneous Melanoma	0.2070	0.1020	1.6e-03	0.031	0.122	0.056	NA	0.113	5.2e-02	3.8e-04	1.3e-02	NA	6.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Alzheimer’s Disease (including proxy)	12.0	17.4	30.7	-3.7	-4.4	-1.6	-5.5	-4.6	4.0
Lung FEV1/FVC ratio	7.3	36.8	57.6	-5.2	-4.3	-7.6	-4.9	-7.4	6.3
Medication for cholesterol, blood pressure or diabetes	7.0	11.7	20.5	-3.6	-3.6	-0.5	-4.2	-4.5	2.5
Heart disease (siblings)	6.4	7.9	12.8	3.0	3.5	1.6	3.6	2.9	-1.6
Medication: Cholesterol lowering	6.3	9.8	16.4	2.8	3.5	0.5	3.8	4.1	-2.7
Pulse rate, automated reading	6.2	20.0	46.9	1.8	6.8	-1.1	6.8	3.1	-3.6
High blood pressure	5.7	15.8	25.0	2.6	4.7	1.3	5.0	4.8	-4.0
Diastolic blood pressure, automated reading	5.6	17.4	31.7	1.5	5.6	1.6	5.6	4.0	-4.5
Hypertension (Self-reported)	5.5	15.2	24.7	2.7	4.7	1.4	5.0	4.6	-3.7
Alzheimer’s Disease (in mother)	5.4	6.4	9.4	-1.9	-2.6	-0.9	-3.0	-3.1	2.9
Had other major operations	5.3	6.5	10.9	-1.4	-3.0	-3.3	-2.7	-1.2	2.8
Father’s age at death	5.2	7.0	10.0	-0.5	-2.9	-2.7	-2.9	-2.8	3.2
Medication: Blood pressure	4.9	8.7	15.1	2.8	3.1	-0.0	3.7	3.9	-2.5
Eye problems/disorders: Cataract	4.8	5.5	14.5	3.8	2.0	1.0	2.5	2.5	-1.1
Cardiovascular Disease	4.6	15.1	24.7	2.6	4.8	0.5	5.0	4.6	-3.8
Vascular/heart problems diagnosed by doctor	4.6	12.6	23.6	-2.6	-3.9	-1.0	-4.3	-4.9	3.3
Illnesses of father: None of the above (group 1)	4.5	5.5	10.0	-0.8	-3.2	-2.6	-2.7	-1.3	2.5
Blood Red Count	4.2	40.3	102.0	-0.6	2.6	5.8	2.9	10.1	-9.5
Hayfever/allergic rhinitis (self-reported)	4.2	5.6	10.5	-0.8	-3.2	-1.2	-3.1	-2.2	2.5
Breast cancer (self-reported)	4.2	5.0	14.7	0.4	-2.4	-0.9	-2.3	-1.8	3.8
Rheumatoid Arthritis	4.0	5.5	11.0	-1.9	-2.4	-0.9	-2.6	-3.3	2.1
Medication: Simvastatin	4.0	5.9	9.6	1.1	3.1	0.5	3.0	2.8	-2.7
Pulse rate	4.0	6.7	13.8	1.4	3.5	-0.7	3.7	2.7	-2.0
Supplements: Glucosamine	3.9	5.1	10.2	0.9	-2.1	-1.9	-2.0	-3.2	2.7
Reason for reducing amount of alcohol drunk: Health precaution	3.8	4.4	7.1	2.0	2.1	2.7	2.1	1.6	-2.0
Age when periods started (menarche)	3.4	8.2	17.5	3.7	4.0	-0.7	4.2	0.7	-0.9
Chronic bronchitis/emphysema (mother)	3.4	3.9	9.8	3.1	1.7	-0.5	2.3	2.2	-0.8
Peak expiratory flow (PEF)	3.3	7.6	20.5	-1.3	-1.5	-2.9	-1.8	-4.5	3.0
Medication: Ventolin 100micrograms inhaler	3.2	4.1	6.1	2.5	1.7	1.8	2.0	2.4	-1.6
Blood Platelet Count	3.1	35.6	136.9	-3.2	-3.8	-11.7	-3.0	-1.7	6.3
Illnesses of siblings	3.1	4.3	7.2	-1.7	-2.7	-2.0	-2.7	-1.2	1.7
Alzheimer’s Disease (in father)	2.9	3.2	5.2	-2.3	-1.3	-1.8	-1.8	-2.0	1.3
Tinnitus: Yes, but not now, but have in the past	2.9	3.1	5.9	0.3	-2.4	-2.3	-2.0	-0.2	1.9
Knee pain experienced in last month	2.9	4.4	9.1	-1.2	-2.5	-3.0	-2.2	-1.2	1.9
Mineral and other dietary supplements	2.9	3.9	6.7	0.5	2.6	1.1	2.4	2.5	-1.8
Medication: Blood pressure	2.9	5.4	8.2	0.6	2.9	1.8	2.7	2.5	-2.8
High cholesterol (Self-reported)	2.9	5.2	10.7	0.6	2.9	0.5	2.9	1.8	-3.3
Supplements: Calcium	2.9	3.2	9.4	-0.8	-1.3	-1.3	-1.4	-3.1	2.0
Breast Cancer	2.7	6.4	10.7	0.6	2.9	2.8	2.9	1.6	-3.3
Mean Putamen Volume	2.7	3.0	5.7	2.1	2.2	0.1	2.4	1.4	-1.3
Birth weight of first child	2.7	4.9	23.7	-1.5	1.0	-1.3	0.5	-4.9	0.7
Neck or shoulder pain in last month	2.7	3.9	8.4	0.4	-2.9	-0.4	-2.9	-0.0	2.5
Osteoarthritis (self-reported)	2.7	3.5	6.6	-1.1	-2.5	-0.7	-2.6	-1.6	2.0
Impedance of leg (right)	2.6	12.7	23.2	1.3	3.6	4.8	3.5	2.1	-4.7
Impedance of leg (left)	2.6	12.6	23.4	1.3	3.5	4.8	3.4	2.3	-4.6
Mother’s age at death	2.6	3.3	6.8	-0.1	-2.0	0.9	-2.2	-2.6	1.8
Medication: Lisinopril	2.6	3.3	6.1	1.5	2.4	-0.3	2.5	2.1	-1.2
Irritability	2.6	4.4	9.0	2.1	1.9	0.6	2.2	3.0	-1.9
Impedance of arm (left)	2.5	11.7	29.3	3.1	2.6	5.4	2.6	2.5	-3.4
Number of full sisters	2.5	3.0	5.9	1.2	2.0	1.0	2.0	2.4	-1.2
Supplements: Vitamin C	2.5	3.0	7.3	-0.3	-2.7	-0.6	-2.4	-1.0	1.8
Medication: Atorvastatin	2.5	3.1	4.1	1.6	1.8	1.8	2.0	1.2	-2.0
Pack years of smoking	2.5	3.7	8.9	1.9	1.8	-0.8	2.2	3.0	-1.1
Impedance of whole body	2.5	12.8	28.2	2.4	3.1	5.3	3.1	2.6	-4.2
Illnesses of father: Heart disease	2.4	3.3	5.9	0.6	2.4	1.9	2.3	1.2	-1.9
Coronary Artery Disease (CAD)	2.3	2.7	4.3	1.1	1.9	-0.1	2.1	1.8	-2.0
Ulcerative Colitis	2.3	3.3	9.3	-0.1	-0.9	-3.1	-0.5	-2.8	1.3
Fluid intelligence score	2.3	4.7	9.4	0.3	2.5	2.4	2.2	1.4	-3.1
Leg pain on walking	2.3	2.9	6.4	-0.5	-2.5	-0.9	-2.5	-0.1	1.9
Hearing aid user	2.3	2.6	4.7	-0.9	-1.9	-2.2	-1.7	-1.1	1.4
Cholesterol lowering medication	2.3	3.4	7.4	-0.5	2.6	0.5	2.4	0.2	-2.7
Pack years adult smoking proportion	2.2	3.4	8.6	1.7	1.7	-0.8	2.0	2.9	-1.2
Lung cancer (father)	2.2	2.6	4.6	-0.5	-1.5	-2.1	-1.2	-2.0	1.8
Alcohol intake frequency.	2.2	5.1	13.5	-1.5	-2.6	-3.7	-2.2	-0.7	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	5.0	-1.9	-2.1	-0.3	-2.2	-1.2	1.1
Verbal and Numeric Reasoning (VNR)	2.1	5.1	9.3	0.5	2.7	2.3	2.4	1.6	-3.0
Allergy	2.1	4.7	11.4	-1.2	3.4	0.5	3.0	-0.0	-2.5
Impedance of arm (right)	2.1	9.8	21.7	2.8	2.5	4.7	2.5	2.5	-3.3
Bipolar Disorder (2018)	2.0	3.2	7.2	1.9	1.6	-0.4	2.0	2.7	-1.2
Smoking status: Previous	2.0	3.0	5.6	0.6	2.3	-0.3	2.4	1.8	-1.8
Medication for cholesterol	2.0	3.1	6.4	0.2	-2.5	0.0	-2.3	-1.2	2.3
Back pain experienced in last month	2.0	3.0	6.7	-1.4	-2.6	-0.6	-2.4	-1.2	1.2
Medication: Atenolol	1.9	2.4	4.4	1.7	1.9	0.3	2.1	1.5	-0.9
Past tobacco smoking	1.9	3.6	6.8	0.1	-2.2	0.0	-2.3	-2.6	2.1
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	3.7	1.7	1.9	1.6	1.9	0.5	-1.0
Supplements: Fish oil (including cod liver oil)	1.9	2.5	6.0	-0.2	-1.8	-1.0	-1.6	-2.5	1.5
Type 2 Diabetes (T2D) (2012)	1.8	2.1	4.5	-1.7	-2.1	-0.3	-2.0	-0.2	1.1
Hand grip strength (left)	1.8	4.8	9.8	0.9	3.1	1.8	2.5	-3.0	-0.5
Hand grip strength (right)	1.8	4.9	10.4	0.8	3.2	2.4	2.7	-2.1	-1.1
Fed-up feelings	1.8	3.3	8.6	-0.5	-2.0	-2.9	-1.8	-0.0	1.9
Hayfever, allergic rhinitis or eczema	1.8	4.0	9.2	0.6	-3.0	-1.7	-2.6	-0.7	2.1
Multivitamins +/- minerals	1.8	2.3	4.0	-0.4	-1.7	-2.0	-1.5	-1.6	1.3
Stomach or abdominal pain in last month	1.8	2.2	5.6	-1.2	-2.4	0.2	-2.3	0.1	0.8
Heart disease (mother)	1.8	2.1	3.0	1.6	1.2	1.7	1.3	1.7	-1.2
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.1	3.3	-0.9	-1.8	-1.4	-1.8	-0.7	1.8
Waist Hip Ratio (WHR)	1.7	7.6	13.8	0.0	3.7	2.5	3.2	2.2	-3.2
Allergy or Eczema	1.7	4.4	11.4	0.7	-3.4	-1.3	-2.9	-1.0	1.9
Noisy workplace	1.7	2.1	6.4	-0.5	-0.8	-2.5	-0.7	-1.4	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	5.1	0.7	-1.6	0.0	-1.4	-1.3	2.3
Number of operations (self-reported)	1.7	2.5	3.5	-1.6	-1.9	-1.7	-1.6	-1.6	1.0
Average weekly beer plus cider intake	1.7	2.4	6.2	-0.7	1.0	1.3	1.0	2.5	-2.1
Pain experienced in last month	1.7	2.9	5.4	0.7	2.3	1.4	2.3	0.9	-1.8
Vitamin and mineral supplements	1.6	2.2	4.0	0.9	2.0	1.3	1.8	1.6	-1.1
Qualifications: CSEs or equivalent	1.6	2.1	3.4	-0.9	-1.7	-1.5	-1.7	-0.5	1.8
Falls in the last year	1.6	2.2	4.0	-2.0	-1.1	-1.4	-1.2	-2.0	0.8
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	4.8	-0.6	2.0	1.3	1.8	1.0	-2.2
Qualifications: College or University degree	1.6	4.9	12.0	0.1	1.8	3.5	1.6	0.6	-3.4
Migraine (self-reported)	1.6	2.0	3.1	-0.8	-1.4	-1.1	-1.6	-1.8	1.6
HbA1C	1.5	1.6	3.8	1.0	-2.0	-0.1	-1.8	-0.5	1.3
Triglycerides	1.5	2.4	3.8	0.6	1.9	0.9	1.8	1.9	-1.5
Lung FVC	1.5	7.7	15.8	1.6	4.0	2.3	3.9	1.3	-2.5
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	4.9	-1.2	-0.9	-2.2	-0.8	-1.2	1.1
High blood pressure (siblings)	1.5	2.2	4.6	0.8	2.1	1.4	2.0	-0.7	-1.1
Illnesses of father: High blood pressure	1.5	1.9	4.5	0.6	2.1	0.3	1.9	0.8	-1.4
Intelligence (Savage-Jansen 2018)	1.4	4.3	7.5	1.7	2.7	1.4	2.5	1.7	-2.2
Forced expiratory volume in 1-second (FEV1)	1.4	4.6	18.1	-1.4	0.3	-1.7	-0.2	-4.3	2.2
Average weekly red wine intake	1.4	2.0	4.9	-1.4	1.7	-0.1	1.5	-0.0	-2.2
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	3.8	-0.2	-1.6	0.4	-1.7	-1.1	1.9
Ever used hormone-replacement therapy (HRT)	1.3	1.7	2.4	-1.4	-0.9	-1.6	-0.9	-1.4	1.5
Relative age voice broke	1.3	1.9	5.4	2.3	1.2	-1.4	1.4	-0.5	0.6
Number of live births	1.3	1.9	4.6	0.8	1.2	2.2	1.0	1.6	-0.9
Illnesses of mother	1.3	1.6	4.5	-2.1	-1.3	0.7	-1.5	-0.9	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.2	17.6	-1.9	0.4	-1.3	-0.2	-4.2	1.4
Birth weight	1.3	2.9	8.3	2.9	1.9	-0.8	2.0	-0.4	0.5
Emphysema/chronic bronchitis	1.3	1.4	3.7	1.9	0.9	-0.8	1.2	1.3	0.3
Handedness (chirality/laterality): Left-handed	1.3	1.6	4.3	-2.1	1.3	0.8	1.0	-0.2	-1.3
Fractured/broken bones in last 5 years	1.3	1.7	6.4	-1.4	-0.8	-0.5	-0.9	-2.5	0.7
Schizophrenia vs Biploar Disorder	1.2	1.5	4.1	-0.8	-1.2	0.2	-1.4	-2.0	0.9
Prostate Cancer	1.2	1.7	4.1	-2.0	-1.8	-0.8	-1.6	0.1	0.1
Trunk fat percentage	1.2	4.7	11.5	3.4	1.7	-0.8	2.0	3.0	0.0
Hair/balding pattern: Pattern 3	1.2	1.8	3.0	0.0	-1.5	1.2	-1.7	-1.3	1.6
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	3.1	-0.3	-1.5	1.8	-1.6	0.4	-0.2
Body fat percentage	1.2	4.6	10.3	3.1	1.6	-1.1	2.0	3.2	0.1
Mean time to correctly identify matches	1.2	2.3	7.0	1.5	0.9	1.2	1.2	2.6	-0.9
Ever smoked	1.2	2.2	5.9	-1.3	1.1	0.0	1.1	2.4	-1.7
Unable to work because of sickness or disability	1.2	1.6	5.6	-0.2	-0.9	-2.4	-0.7	-0.9	1.4
Alcohol drinker status: Previous	1.2	1.4	3.7	-1.9	0.4	-1.9	0.3	-0.2	-0.8
Depression (Nagel 2018)	1.1	1.6	4.2	0.8	1.4	0.2	1.4	2.0	-1.0
Bipolar Disorder (2011)	1.1	1.1	1.7	-0.3	1.2	-1.3	1.3	0.8	-1.1
Systolic Blood Pressure	1.1	5.3	11.6	-0.3	2.1	0.1	2.3	3.4	-3.3
Ever had hysterectomy (womb removed)	1.1	1.2	1.8	-0.8	-1.2	-0.4	-1.3	-1.3	1.2
Townsend deprivation index at recruitment	1.1	1.5	2.7	0.2	1.5	0.1	1.7	1.6	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	5.8	-0.1	1.4	1.5	1.3	1.7	-2.4
Mouth/teeth dental problems	1.1	1.7	5.7	2.4	1.2	-0.4	1.3	-0.2	1.1
Leg fat percentage (right)	1.1	4.0	10.3	1.9	1.9	-1.2	2.2	3.2	-0.7
Worry too long after embarrassment	1.1	1.8	3.0	1.0	1.6	0.6	1.7	1.3	-1.4
Chest pain or discomfort	1.1	1.5	8.0	0.8	-0.7	-0.0	-0.2	2.8	-0.4
Medication: Bendroflumethiazide	1.1	1.6	2.8	-0.0	1.7	-0.1	1.7	1.3	-1.6
Primary Biliary Cirrhosis	1.0	1.4	6.6	-0.1	0.5	2.6	0.4	0.4	-1.0
Type 2 Diabetes (T2D) (2018)	1.0	2.0	6.5	0.2	1.1	0.3	1.2	2.6	-1.6
Angina	1.0	1.3	6.0	0.6	-0.4	0.6	-0.0	2.4	-0.8
Eye problems/disorders: None of the above	1.0	1.2	3.3	-1.8	-0.6	-0.5	-1.0	-1.3	0.6
Commuting to job workplace: Walk	1.0	1.1	2.2	1.4	1.2	-0.5	1.5	0.1	-0.7
Guilty feelings	1.0	1.6	4.4	-1.3	1.0	0.8	0.9	1.0	-2.1
Leg fat percentage (left)	1.0	3.7	10.5	1.8	1.7	-1.3	1.9	3.2	-0.4
Age started oral contraceptive pill	1.0	1.3	2.8	0.9	0.9	1.7	0.9	1.0	-1.2
Bipolar Disorder or Schizophrenia	0.9	2.1	3.9	2.0	1.5	-0.3	1.8	1.8	-0.4
BMI	0.9	5.2	21.5	0.7	-0.4	-4.6	0.1	2.6	1.5
Sitting height	0.9	6.5	29.7	-1.6	-1.0	0.3	-1.6	-5.5	1.8
Body mass index (BMI)	0.9	3.6	14.9	0.8	-0.2	-3.9	0.0	1.7	1.9
Medication: Ramipril	0.9	1.1	5.4	2.3	0.0	0.0	0.2	0.8	0.9
Happiness	0.9	1.1	2.6	-0.4	-1.6	0.3	-1.6	-0.3	1.1
Pulse wave Arterial Stiffness index	0.9	1.1	2.1	-0.9	1.1	-0.3	1.1	1.0	-1.5
Blood clot in the leg (DVT)	0.9	1.2	3.0	-0.1	-1.2	0.1	-1.4	-0.8	1.7
Angina (self-reported)	0.9	1.2	5.8	0.6	-0.4	0.6	-0.0	2.4	-0.9
Medication: Seretide 50 evohaler	0.9	1.0	3.0	1.7	0.3	-0.0	0.8	1.5	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	1.4	-0.8	-1.1	-0.9	-1.1	-1.1	1.2
Suffer from ‘nerves’	0.9	1.5	3.0	-1.1	-1.2	-0.9	-1.0	-1.7	1.1
Arm fat percentage (left)	0.9	3.4	7.3	2.6	0.4	-2.0	0.7	2.7	1.2
Qualifications: nursing, teaching	0.9	1.4	2.8	0.1	1.5	1.7	1.1	-0.1	-1.5
Tinnitus: Yes, now most or all of the time	0.9	1.0	1.8	0.6	1.4	0.3	1.3	0.7	-1.2
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.0	-1.1	-1.4	-0.9	-1.2	0.9	-0.2
Myopia	0.9	1.3	3.0	0.3	1.7	-0.0	1.7	-0.4	-1.3
Major Depression (MDD)	0.8	1.0	4.7	0.3	0.6	-2.2	0.7	-0.3	0.5
Smoking Status	0.8	1.8	7.0	-0.6	1.1	-0.6	1.1	2.6	-0.9
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.1	-1.4	-1.3	0.5	-1.0	-0.0	-1.1
Leg fat-free mass (left)	0.8	4.1	10.5	0.5	-0.4	-3.2	-0.5	-2.1	3.0
Maternal smoking around birth	0.8	1.1	3.8	0.2	0.8	-0.8	1.1	1.9	-0.6
Medication: Levothyroxine sodium	0.8	1.3	2.2	-1.1	-1.5	-0.7	-1.5	-1.2	0.4
Leg predicted mass (left)	0.8	4.1	10.6	0.5	-0.4	-3.3	-0.4	-2.0	3.0
Trunk fat mass	0.8	3.2	7.7	2.8	1.6	-1.4	1.8	1.9	0.5
Hearing difficulty/problems with background noise	0.8	1.3	1.9	1.2	1.3	0.7	1.3	1.4	-0.9
Hair/balding pattern: Pattern 2	0.8	1.1	3.0	-0.1	1.3	-0.4	1.3	0.0	-1.7
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.8	-1.7	-0.1	-1.2	-0.1	-1.2	0.1
Pain all over the body in last month	0.8	0.9	2.3	1.1	0.4	-1.5	0.5	-0.5	1.0
Arm fat percentage (right)	0.8	3.1	6.7	2.4	0.3	-2.1	0.7	2.6	1.3
Trunk fat-free mass	0.8	4.4	13.2	-0.8	-0.3	-2.3	-0.7	-3.6	2.7
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.3	-0.5	-1.5	-1.2	-1.5	-0.5	1.3
Trunk predicted mass	0.8	4.5	13.0	-0.8	-0.4	-2.3	-0.7	-3.6	2.7
Medication: Amlodipine	0.8	1.1	2.8	0.1	1.1	-0.1	1.3	1.7	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	1.9	0.1	1.2	-1.3	1.4	0.8	-0.8
Age at first live birth	0.8	1.3	4.6	-0.9	-1.0	-0.3	-1.2	-2.1	0.1
Pulse wave peak to peak time	0.8	0.9	1.6	0.9	-0.8	0.6	-0.8	-1.2	1.3
Medication: Allopurinol	0.8	1.1	2.0	1.3	1.1	-1.4	1.2	0.4	0.3
Illnesses of siblings: Diabetes	0.8	0.9	2.0	-1.0	-1.4	0.1	-1.3	-0.9	0.3
Leg fat-free mass (right)	0.8	4.5	10.8	0.3	-0.7	-3.3	-0.8	-2.2	3.2
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	3.8	2.0	0.2	0.3	0.5	0.8	0.2
Friendships satisfaction	0.8	1.0	2.3	-0.8	-1.4	-0.0	-1.5	-0.9	0.6
Medication: Gliclazide	0.8	0.8	1.4	-1.1	-1.2	-0.5	-1.2	-0.7	0.5
Whole body water mass	0.8	4.5	9.6	-0.4	-0.4	-2.9	-0.6	-3.1	3.0
Leg predicted mass (right)	0.8	4.5	10.7	0.4	-0.7	-3.3	-0.8	-2.1	3.3
Risk taking	0.8	1.1	2.1	-0.8	-0.9	1.0	-1.1	-1.5	1.1
Arm predicted mass (left)	0.8	4.0	9.3	-0.7	-0.3	-3.0	-0.5	-2.6	2.6
Neuroticism (Nagel 2018)	0.7	1.7	3.5	0.6	1.3	0.1	1.5	1.6	-1.9
Crohns Disease (2017)	0.7	1.5	2.5	0.4	1.6	1.2	1.4	0.9	-1.4
Ulcerative Colitis (UC)	0.7	1.4	5.0	0.2	-0.0	-1.7	0.2	-2.2	0.7
Reaction Time	0.7	1.3	4.7	1.1	0.7	0.3	1.0	2.2	-0.5
Age at First Birth	0.7	1.1	5.6	-0.8	-0.2	-0.3	-0.3	-2.4	0.1
HDL Cholesterol	0.7	1.2	2.2	0.5	-1.5	-0.8	-1.2	-0.8	1.5
LDL Cholesterol	0.7	1.2	1.7	0.9	1.3	1.2	1.3	0.9	-0.8
Height	0.7	12.9	26.9	1.6	4.8	2.8	4.0	-5.2	-1.1
Respiratory disease	0.7	1.5	4.0	1.7	-0.6	2.0	-0.4	1.3	0.1
Relative age of first facial hair	0.7	1.5	3.4	1.2	1.9	-0.8	1.8	-0.4	-0.1
Systolic blood pressure, automated reading	0.7	1.9	5.0	-0.7	1.0	0.3	1.1	2.2	-2.0
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.8	-1.3	-0.8	-0.4	-1.0	-1.1	0.3
Chronic bronchitis/emphysema (father)	0.7	0.9	1.8	0.2	1.2	0.4	1.1	1.4	-0.8
Alcohol intake versus 10 years previously	0.7	1.0	5.2	0.2	-0.2	-0.9	0.1	2.3	-0.2
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.9	-1.1	0.7	2.2	0.3	-0.4	-1.7
Asthma	0.7	1.3	3.2	1.8	-0.2	1.6	0.0	1.5	0.1
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.7	0.8	1.2	-0.5	1.3	1.1	-0.3
Gout (self-reported)	0.7	1.0	2.2	1.2	0.9	-1.5	0.9	0.4	0.8
Arm fat-free mass (right)	0.7	3.7	8.0	-0.6	-0.0	-2.8	-0.3	-2.8	2.4
Wheeze or whistling in the chest in last year	0.7	1.3	2.7	0.1	-1.2	-1.5	-0.9	1.6	0.8
Medication: Omeprazole	0.7	0.9	4.3	-0.7	-0.4	-2.1	-0.3	0.0	0.4
Whole body fat mass	0.7	3.1	5.3	2.3	1.4	-2.0	1.6	2.0	0.8
Leg fat mass (right)	0.7	2.7	5.5	1.5	1.4	-2.3	1.6	1.8	0.4
Arm predicted mass (right)	0.7	3.4	7.2	-0.5	-0.1	-2.7	-0.3	-2.6	2.4
Overall health rating	0.7	1.6	2.5	-1.5	-1.6	-1.5	-1.4	-0.2	0.5
Whole body fat-free mass	0.7	4.0	8.6	-0.3	-0.3	-2.7	-0.5	-2.9	2.8
Diabetes diagnosed by doctor	0.7	1.1	2.6	-0.8	0.8	-0.5	0.8	1.6	-1.3
Asthma (self-reported)	0.7	1.4	3.8	1.9	-0.0	1.5	0.2	1.6	-0.1
Alcohol drinker status: Never	0.7	0.9	2.7	-0.0	-1.6	0.3	-1.4	-0.4	0.3
Arm fat-free mass (left)	0.7	3.7	9.1	-0.7	-0.1	-3.0	-0.3	-2.6	2.5
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.0	0.8	0.7	1.4	0.7	-0.0	-1.0
Leg fat mass (left)	0.7	2.7	5.7	1.6	1.3	-2.4	1.5	2.0	0.6
Ovarian Cancer	0.6	0.8	2.3	-0.2	0.7	0.1	0.8	1.1	-1.5
Neuroticism (2016)	0.6	0.9	1.8	0.1	1.2	0.2	1.3	1.0	-1.2
Chronotype (morning person)	0.6	1.3	4.3	-0.2	-1.2	-1.0	-1.0	-2.1	0.5
Number of treatments/medications taken	0.6	1.0	5.1	0.5	-0.0	0.1	0.2	2.3	-0.9
Supplements: Zinc	0.6	0.7	2.8	1.7	0.4	-0.4	0.6	0.5	0.6
Taking other prescription medications	0.6	0.9	2.4	0.4	-0.6	1.5	-0.4	1.3	-1.0
High blood pressure (mother)	0.6	0.8	3.8	1.9	-0.1	-0.4	0.0	0.1	1.0
Had menopause	0.6	0.8	2.3	-0.2	-0.1	-0.8	-0.2	-1.5	1.3
Forced vital capacity (FVC)	0.6	2.1	4.4	0.6	2.1	1.1	1.7	-2.0	0.2
Heart attack	0.6	0.8	3.2	0.7	-0.2	1.8	-0.1	1.1	-0.1
Diabetes (self-reported)	0.6	0.9	2.6	-0.7	0.5	-0.5	0.6	1.6	-1.1
Mouth/teeth dental problems: Dentures	0.6	1.0	3.4	-1.8	-1.0	-0.4	-1.1	0.5	-0.4
Arm fat mass (right)	0.6	2.6	7.2	1.6	0.4	-2.7	0.6	1.4	1.7
Standing height	0.6	5.5	13.6	1.2	2.5	2.9	1.9	-3.7	-0.4
Hair/balding pattern: Pattern 4	0.6	1.5	1.9	-0.7	-1.4	-1.3	-1.4	-1.2	1.3
Forced vital capacity (FVC), Best measure	0.6	2.3	4.7	-0.1	2.1	1.0	1.8	-2.2	-0.5
Number of full brothers	0.6	0.8	1.2	1.0	0.9	1.1	1.0	0.8	-0.4
Loneliness, isolation	0.6	0.8	1.5	-0.8	-1.2	-0.6	-1.2	0.9	0.5
Long-standing illness, disability or infirmity	0.6	0.9	1.7	-0.6	-1.3	0.5	-1.0	0.9	-1.2
Smoking status: Current	0.6	0.9	2.3	-1.5	-0.9	0.3	-1.0	1.1	0.0
Arm fat mass (left)	0.6	2.7	7.5	1.7	0.4	-2.7	0.6	1.5	1.7
Number of self-reported non-cancer illnesses	0.6	1.0	2.6	-0.4	0.4	0.8	0.7	1.3	-1.6
Ever taken oral contraceptive pill	0.6	0.6	1.1	-0.4	-0.9	1.1	-1.1	0.4	0.5
Medication: Paracetamol	0.6	1.0	2.2	-0.2	-1.0	-1.3	-0.8	1.5	0.6
Basal metabolic rate	0.6	3.3	7.5	0.2	0.0	-2.7	-0.1	-2.3	2.6
Heart attack/myocardial infarction (self-reported)	0.6	0.7	3.1	0.7	-0.0	1.8	0.0	0.9	-0.2
Body Mass Index (BMI) (2010)	0.5	0.7	1.6	0.6	0.8	-0.5	1.0	1.3	-0.4
Crohns Disease (2012)	0.5	0.8	1.9	-1.4	0.3	1.0	0.1	-0.1	-1.4
Fasting Glucose	0.5	0.5	1.6	1.1	0.3	1.2	0.1	0.3	0.5
Lupus	0.5	0.8	2.0	-1.1	0.4	-1.0	0.6	0.4	-1.4
Heel T-Score	0.5	4.3	13.2	-2.4	0.6	2.1	0.3	1.5	-3.6
Hearing difficulty/problems: Yes	0.5	0.7	1.3	0.9	1.1	-0.4	1.1	0.8	-0.4
Current tobacco smoking	0.5	0.8	2.3	-1.4	-0.5	0.1	-0.5	1.5	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.6	-0.8	0.6	0.9	0.5	1.0	-1.9
Hip circumference	0.5	2.1	5.2	1.6	-0.2	-2.1	-0.1	0.4	2.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.3	-0.7	-1.1	0.0	-1.1	-0.8	0.3
Medication: Ibuprofen	0.5	0.6	1.2	0.7	-0.9	0.5	-0.9	0.2	1.1
Had major operations	0.5	0.6	1.2	-0.2	-1.1	-0.8	-0.9	-0.8	-0.0
Ever had bowel cancer screening	0.5	0.6	1.4	1.2	0.7	-1.0	0.7	-0.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.6	0.5	0.3	-0.2	-0.1	-1.5	1.9
Miserableness	0.5	0.9	1.9	-0.5	0.8	0.6	0.6	1.3	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.5	-1.1	-0.6	-1.2	-0.5	0.0	0.2
Worry (Nagel 2018)	0.4	0.9	2.5	-1.6	-0.7	0.1	-0.5	-1.4	-0.4
Blood White Count	0.4	2.6	12.7	0.4	0.2	-1.6	0.6	3.6	-0.1
Average weekly spirits intake	0.4	0.5	1.3	-1.1	-0.2	-1.1	-0.0	0.5	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.9	0.4	0.1	-1.0	0.2	1.4	-0.0
Waist circumference	0.4	1.5	2.9	1.1	1.0	-1.6	0.9	1.7	0.8
Weight	0.4	1.9	5.6	1.3	0.9	-2.4	0.9	-0.2	1.7
Depression (self-reported)	0.4	0.5	2.3	-0.5	0.2	-1.5	0.3	-0.5	-0.0
Medication: Lansoprazole	0.4	0.4	1.0	-1.0	-0.4	0.1	-0.4	-1.0	-0.5
Length of working week for main job	0.4	0.4	1.1	-1.1	0.5	0.2	0.5	-0.5	-0.8
Breastfed as a baby	0.4	0.4	1.1	0.4	-0.8	-0.1	-0.8	1.0	0.4
Pulse wave reflection index	0.4	0.4	1.2	-0.7	0.8	0.1	0.6	-0.1	-1.1
Loud music exposure frequency	0.4	0.4	1.0	0.1	0.7	0.1	0.8	1.0	-0.6
Medication: Paracetamol	0.4	0.6	2.1	-0.3	-0.5	-1.2	-0.4	1.4	0.1
Shortness of breath walking on level ground	0.4	0.5	1.3	1.1	0.0	-0.5	0.4	1.2	-0.1
Family relationship satisfaction	0.4	0.5	1.7	-1.3	0.2	0.8	-0.0	-0.0	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.1	-0.9	-0.5	0.8	-0.5	0.6	-1.4
Wears glasses or contact lenses	0.4	0.5	1.0	0.3	0.5	0.8	0.3	0.8	-1.0
Financial situation satisfaction	0.4	0.4	1.1	-0.2	-0.6	-0.6	-0.7	-0.6	1.0
Depressed Affect (Nagel 2018)	0.3	0.7	2.6	0.9	0.3	-0.5	0.4	1.6	-0.6
Irritable Bowel Disease (IBD)	0.3	0.6	1.2	0.7	0.9	-0.8	1.1	-0.7	-0.1
Medication for hormone replacement therapy	0.3	0.4	1.4	-1.2	0.4	-0.2	0.3	-0.1	-0.7
Diabetes (father)	0.3	0.3	1.1	-0.9	0.1	0.2	0.2	0.2	-1.0
Diabetes (mother)	0.3	0.4	0.9	-0.7	-0.1	-1.0	0.1	0.9	-0.4
Serious illness, injury or assault to yourself	0.3	0.4	1.1	-0.0	-0.8	-1.1	-0.4	-0.1	0.6
Qualifications: None of the above	0.3	0.7	3.0	0.2	-0.3	-1.7	-0.1	0.6	0.9
Time employed in main current job	0.3	0.4	1.2	0.2	-0.0	0.5	0.2	0.9	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.7	-1.3	0.4	-0.8	0.3	0.1	-0.5
Number of children fathered	0.3	0.4	0.9	-0.4	-1.0	-0.6	-0.8	0.4	0.2
Medication for pain relief, constipation, heartburn	0.3	0.5	1.5	0.2	1.0	0.1	0.8	-1.2	-0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.0	-0.7	-0.8	0.3	-1.0	0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.7	-0.3	0.2	-0.5	0.0	-1.6	0.8
Osteoporosis (self-reported)	0.3	0.4	1.4	0.9	0.1	0.4	0.4	1.2	-0.2
Commuting to job workplace: Public transport	0.3	0.4	1.0	-0.1	-1.0	0.3	-0.7	0.8	-0.0
Eye problems/disorders: Glaucoma	0.3	0.3	1.4	-0.4	0.1	0.2	0.2	1.2	-0.5
Schizophrenia (2018)	0.2	0.4	1.0	1.0	0.7	-0.1	0.6	0.1	0.5
Hypothyroidism (self reported)	0.2	0.5	0.9	-0.4	-0.9	0.5	-1.0	-0.8	0.2
Sensitivity / hurt feelings	0.2	0.4	0.8	0.8	-0.1	-0.9	-0.0	0.1	0.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.9	-0.5	0.0	-0.9	0.1	0.0	-0.3
Medication: Co-codamol	0.2	0.3	0.8	0.9	-0.3	-0.3	0.1	0.8	0.0
Medication: Metformin	0.2	0.3	0.7	0.8	0.3	-0.6	0.4	0.8	0.3
Average weekly fortified wine intake	0.2	0.2	0.4	-0.5	-0.5	0.4	-0.7	0.2	-0.2
Number of incorrect matches in round	0.2	0.3	0.8	0.1	0.9	-0.1	0.7	-0.4	-0.7
Nervous feelings	0.2	0.3	1.3	-0.1	0.3	1.1	0.4	-0.0	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.4	-0.0	0.2	0.2	-0.2	-1.2	0.6
Financial difficulties in last 2 years	0.2	0.2	0.6	-0.1	-0.5	-0.2	-0.5	0.8	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	0.3	-0.6	0.5	-0.7	0.3	0.6
Exposure to tobacco smoke at home	0.2	0.2	0.8	-0.9	-0.2	-0.3	-0.2	-0.5	0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	-0.4	-0.7	0.6	-0.9	-0.9	0.1
Exposure to tobacco smoke outside home	0.2	0.2	0.9	0.0	0.3	-1.0	0.4	0.4	0.3
Health satisfaction	0.2	0.3	1.3	0.5	-0.3	-0.3	-0.1	1.1	-0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.7	0.1	0.5	0.6	0.4	0.8	-0.2
Age at last live birth	0.2	0.3	0.8	0.4	0.3	0.8	0.4	0.0	-0.9
Medication: Aspirin	0.2	0.3	1.3	-0.1	0.2	0.4	0.2	1.1	-0.4
Mood swings	0.2	0.4	1.3	0.5	0.2	-1.1	0.4	0.7	0.2
Average weekly champagne plus white wine intake	0.2	0.3	0.9	0.9	0.6	0.1	0.5	-0.0	-0.0
Basal cell carcinoma (self-reported)	0.2	0.3	0.8	0.7	0.4	0.0	0.3	0.9	0.2
Schizophrenia (2014)	0.1	0.3	0.6	0.8	0.6	-0.5	0.7	0.2	0.1
Blood Eosinophil Count	0.1	0.9	3.0	1.7	-0.2	-0.7	0.5	1.3	-0.2
Neuroticism	0.1	0.1	0.5	0.1	-0.1	-0.2	0.1	0.7	-0.5
Hair Pigment	0.1	4.0	8.9	-0.6	-1.9	-1.4	-2.1	-2.1	3.0
Tanning	0.1	1.0	2.9	0.5	0.3	-1.0	0.2	-1.3	1.7
Severe depression (siblings)	0.1	0.1	0.2	0.3	0.4	0.1	0.4	0.5	-0.3
Alcohol usually taken with meals	0.1	0.1	0.4	-0.2	-0.3	0.6	-0.3	-0.4	0.1
Neuroticism score	0.1	0.2	1.0	0.5	-0.0	-0.1	0.2	1.0	-0.2
Worrier / anxious feelings	0.1	0.1	0.3	0.2	0.4	0.0	0.5	0.2	-0.6
Prospective memory result	0.1	0.1	0.3	-0.2	-0.2	-0.5	-0.3	0.2	0.3
Headache pain in last month	0.1	0.3	0.6	-0.4	-0.7	0.2	-0.8	0.2	0.3
Glaucoma (self-reported)	0.1	0.1	0.3	-0.5	0.3	0.1	0.3	0.3	-0.4
Comparative body size at age 10	0.1	0.4	1.6	-0.6	0.2	-0.2	0.1	-1.3	-0.6
Comparative height size at age 10	0.1	0.4	1.6	-0.3	-0.2	0.5	-0.5	-1.2	0.6
Medication: Aspirin	0.1	0.2	0.5	-0.4	-0.1	0.1	-0.0	0.7	-0.4
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.4	-0.5	0.1	-0.3	-0.3	0.2
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.3	0.2	0.1	0.0	0.1	0.5	0.1
Tense / ‘highly strung’	0.0	0.1	0.1	-0.2	0.4	0.1	0.4	-0.4	0.1
Ever depressed for a whole week	0.0	0.0	0.1	-0.3	-0.0	0.1	-0.0	-0.3	0.2

Hub : Genes

ZKSCAN1

Models

Trait associations