Best TWAS P=4.14e-15 · Best GWAS P=3.7e-17 conditioned to 0.00311
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | AMPD3 | 0.20 | 0.02 | lasso | 8 | 0.01 | 5.5e-02 | 5.61 | -5.4 | 8.8e-08 | -0.21 | 0.30 | 0.06 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | SBF2 | 0.16 | 0.14 | lasso | 4 | 0.14 | 6.8e-11 | -4.46 | 5.2 | 1.8e-07 | 0.40 | 0.99 | 0.01 | FALSE |
| 3 | GTEx | Prostate | SBF2 | 0.21 | 0.05 | lasso | 7 | 0.03 | 6.7e-02 | -6.89 | -7.6 | 2.7e-14 | -0.70 | 0.06 | 0.67 | FALSE |
| 4 | GTEx | Testis | SBF2 | 0.10 | 0.01 | lasso | 5 | 0.02 | 5.0e-02 | -6.38 | 7.0 | 3.4e-12 | 0.66 | 0.15 | 0.59 | FALSE |
| 5 | METSIM | Adipose | AMPD3 | 0.06 | 0.03 | enet | 14 | 0.05 | 7.8e-08 | -6.36 | -6.3 | 3.8e-10 | -0.08 | 0.96 | 0.00 | TRUE |
| 6 | NTR | Blood | ADM | 0.04 | 0.04 | enet | 13 | 0.04 | 1.6e-13 | -6.83 | 7.7 | 1.9e-14 | 0.75 | 0.43 | 0.57 | FALSE |
| 7 | NTR | Blood | WEE1 | 0.02 | 0.00 | bslmm | 367 | 0.00 | 1.0e-02 | 0.71 | 5.2 | 1.9e-07 | 0.34 | 0.10 | 0.20 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | SBF2-AS1 | 0.03 | 0.00 | bslmm | 362 | 0.01 | 4.4e-03 | 1.50 | -5.8 | 5.2e-09 | -0.25 | 0.04 | 0.67 | FALSE |
| 9 | YFS | Blood | ADM | 0.08 | 0.11 | enet | 25 | 0.12 | 9.4e-36 | -7.02 | 7.9 | 4.1e-15 | 0.77 | 0.99 | 0.01 | TRUE |