Hub : Genes

WEE1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0200	0.0092	0.00290	0.002	0.003	0.003	0.005	0.003	0.066	2.2e-02	3.5e-02	1e-02	4.1e-02
2	YFS	Blood	0.0268	0.0117	0.00046	0.002	0.013	0.013	0.014	0.012	0.051	2.1e-05	3.3e-05	2e-05	6.9e-05
3	TCGA	Colon Adenocarcinoma	0.0580	0.0290	0.00250	0.011	0.043	0.018	NA	0.012	0.069	1.6e-03	3.0e-02	NA	6.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.3	0.7	-0.1	-0.4	0.8
Bipolar Disorder or Schizophrenia	0.0	0.1	0.1	0.1	-0.1	0.4
Depressed Affect (Nagel 2018)	0.1	0.2	0.6	0.1	-0.8	-0.2
Depression (Nagel 2018)	0.2	0.4	0.9	0.4	1.0	-0.0
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.3	-0.5	0.5	0.0
Neuroticism (Nagel 2018)	1.0	2.3	6.0	0.8	0.5	-2.4
Schizophrenia (2018)	0.0	0.0	0.1	0.2	0.2	-0.2
Schizophrenia vs Biploar Disorder	1.2	1.5	2.3	0.9	-1.5	1.2
Worry (Nagel 2018)	1.0	2.0	3.2	1.1	1.3	-1.8
Alzheimer’s Disease (in mother)	2.5	2.9	5.3	0.7	1.7	-2.3
Alzheimer’s Disease (in father)	0.4	0.4	0.9	0.5	0.5	-1.0
Alzheimer’s Disease (including proxy)	4.9	7.1	10.9	1.6	2.8	-3.3
Crohns Disease (2017)	0.8	1.8	2.5	1.6	1.4	-1.1
Irritable Bowel Disease (IBD)	0.3	0.7	1.4	0.5	-0.7	-1.2
Ulcerative Colitis (UC)	1.3	2.4	5.6	-0.9	-2.4	-0.9
Major Depression (MDD)	0.6	0.7	1.3	-0.8	0.1	-1.2
Reaction Time	0.2	0.4	0.8	0.4	-0.9	0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.9	-1.0	-0.7	-0.0
Breast Cancer	1.3	3.1	8.5	-2.9	-0.6	0.6
Ovarian Cancer	0.1	0.1	0.2	0.1	0.4	-0.1
Prostate Cancer	3.2	4.5	7.0	2.6	1.7	-1.8
Age at First Birth	0.3	0.4	0.7	-0.6	-0.8	0.3
Bipolar Disorder (2011)	3.4	3.3	4.9	-2.2	-1.5	1.6
Body Mass Index (BMI) (2010)	0.9	1.2	2.4	1.6	0.4	0.9
Coronary Artery Disease (CAD)	1.3	1.6	2.5	-0.2	-1.6	1.5
Crohns Disease (2012)	0.0	0.0	0.0	0.2	-0.0	0.1
Mean Putamen Volume	2.3	2.6	4.0	-1.6	-2.0	1.0
Fasting Glucose	0.5	0.6	1.3	-1.1	-0.8	0.0
HbA1C	7.0	7.8	8.2	2.9	2.8	-2.7
HDL Cholesterol	1.0	1.6	3.9	-0.1	1.0	-2.0
LDL Cholesterol	1.5	2.4	4.5	0.9	-1.4	2.1
Lupus	0.2	0.2	0.6	-0.1	0.3	-0.8
Neuroticism (2016)	3.6	5.2	9.2	1.9	1.7	-3.0
Primary Biliary Cirrhosis	0.2	0.3	1.0	1.0	0.1	0.2
Rheumatoid Arthritis	6.1	8.4	12.4	-3.5	-3.3	1.4
Schizophrenia (2014)	0.1	0.1	0.3	-0.2	0.1	-0.6
Triglycerides	0.5	0.8	2.0	0.7	0.0	1.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.1	-0.4	-0.7
Ulcerative Colitis	0.6	0.8	2.2	-0.5	-1.5	-0.1
Blood Eosinophil Count	0.7	5.5	9.7	-1.1	-3.1	2.4
Blood Platelet Count	1.5	17.2	23.7	4.9	4.8	-2.2
Blood Red Count	0.7	6.4	17.7	-4.2	-0.5	1.1
Blood White Count	0.3	2.1	3.9	-2.0	-0.8	-1.4
Heel T-Score	1.0	8.2	13.0	2.1	3.6	-2.7
BMI	0.4	2.1	3.2	-1.5	-1.8	0.8
Height	0.4	6.7	13.7	-3.7	-2.5	0.6
Waist Hip Ratio (WHR)	2.0	8.8	13.7	2.7	2.4	-3.7
Systolic Blood Pressure	1.1	5.5	10.2	-0.2	-2.5	3.2
Smoking Status	0.0	0.1	0.2	0.3	-0.4	0.1
Allergy or Eczema	0.2	0.6	1.1	-0.8	-1.0	-0.2
Cardiovascular Disease	1.9	6.3	12.7	-3.6	-2.5	-0.1
Hypothyroidism (self reported)	2.7	6.2	9.4	-3.1	-3.0	0.6
Respiratory disease	0.2	0.4	1.1	0.1	-1.0	-0.3
Type 2 Diabetes (T2D) (2018)	0.9	1.7	4.6	0.2	0.7	-2.2
Lung FEV1/FVC ratio	1.0	4.8	13.4	3.7	-0.6	0.9
Lung FVC	0.3	1.7	2.3	1.5	1.5	-0.8
Neuroticism	1.4	3.5	9.0	0.8	0.8	-3.0
Chronotype (morning person)	0.8	2.0	3.3	-0.5	-1.8	1.5
Hair Pigment	0.3	8.4	19.0	-4.4	-2.1	1.4
Tanning	0.4	4.6	11.4	3.4	1.6	0.1
Hand grip strength (left)	0.2	0.6	1.3	-1.2	0.6	-0.0
Number of treatments/medications taken	0.2	0.4	1.2	0.3	-1.1	0.1
Average weekly spirits intake	0.4	0.4	1.3	0.2	0.0	1.1
Sensitivity / hurt feelings	1.7	3.0	8.4	0.8	-0.1	-2.9
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.3	0.5	0.5	0.5
Hearing difficulty/problems: Yes	0.1	0.2	0.4	-0.6	-0.5	0.1
Relative age of first facial hair	0.3	0.6	1.0	0.2	-0.9	-1.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	3.1	0.5	-0.0	-1.8
Ever used hormone-replacement therapy (HRT)	2.3	2.9	3.7	1.8	1.3	-1.9
Ever had hysterectomy (womb removed)	0.7	0.8	2.2	1.5	-0.2	-0.0
Systolic blood pressure, automated reading	1.2	3.4	6.6	1.9	0.3	2.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.7	-0.5	0.8	-0.5
Angina	2.0	2.6	3.7	-1.8	-1.9	1.0
Medication for hormone replacement therapy	0.1	0.1	0.3	0.2	0.6	-0.0
Vitamin and mineral supplements	0.1	0.1	0.2	-0.4	-0.5	0.3
Supplements: Zinc	0.1	0.1	0.3	0.0	-0.2	0.6
Medication: Co-codamol	1.2	1.4	1.8	1.3	1.0	1.3
Medication: Metformin	0.0	0.0	0.1	-0.3	-0.2	0.1
Diabetes (father)	1.2	1.5	2.7	0.1	1.6	-1.4
Diabetes (mother)	0.7	0.9	1.4	-1.2	-0.2	-1.1
Severe depression (siblings)	0.3	0.3	0.6	0.6	-0.0	0.7
Pack years adult smoking proportion	1.4	2.2	4.5	-2.1	-1.4	-0.2
Impedance of leg (right)	3.3	16.0	19.0	4.4	3.5	-4.1
Leg fat-free mass (left)	2.7	14.2	21.0	-4.6	-3.7	2.8
Trunk fat percentage	0.7	2.7	4.0	2.0	1.2	-1.6
Hand grip strength (right)	0.2	0.6	1.4	-1.2	0.6	0.4
Townsend deprivation index at recruitment	0.2	0.3	0.9	0.1	-0.4	-0.9
Current tobacco smoking	0.3	0.4	0.8	-0.7	0.2	-0.9
Average weekly fortified wine intake	3.5	4.1	8.9	1.7	3.0	-0.8
Maternal smoking around birth	0.9	1.3	3.7	-0.2	-1.9	0.3
Fed-up feelings	0.2	0.4	0.6	0.5	-0.5	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.1	1.5	0.9	-0.0
Relative age voice broke	0.9	1.4	3.9	0.4	-0.2	-2.0
Taking other prescription medications	0.4	0.6	1.7	1.3	-0.3	-0.3
Age when periods started (menarche)	0.5	1.2	2.2	0.9	-0.7	1.5
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	2.3	0.8	1.2	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.5	8.2	2.9	1.4	0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	-0.1	-0.2	0.9
Qualifications: CSEs or equivalent	0.4	0.6	1.3	-0.1	0.6	-1.1
Serious illness, injury or assault to yourself	0.4	0.5	0.9	0.7	0.1	-1.0
High blood pressure	1.3	3.6	5.5	-2.1	-2.4	0.8
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.2	-0.8	-1.1	-0.0
Multivitamins +/- minerals	0.1	0.1	0.2	0.5	0.2	0.1
Stomach or abdominal pain in last month	0.4	0.5	1.2	-0.3	-0.2	-1.1
Supplements: Glucosamine	1.3	1.8	3.2	1.8	1.4	-0.2
Diverticular disease/diverticulitis (self-reported)	2.4	2.9	4.5	2.1	1.2	-1.6
Medication: Atenolol	1.8	2.2	3.1	-1.3	-1.8	1.4
Medication: Levothyroxine sodium	1.7	3.0	4.5	-2.1	-2.1	0.1
Sitting height	0.3	2.4	4.5	-2.1	1.2	-1.2
Chronic bronchitis/emphysema (father)	1.9	2.2	3.6	0.9	1.5	-1.9
High blood pressure (mother)	0.2	0.2	0.6	-0.3	0.8	-0.1
Body mass index (BMI)	0.4	1.9	3.2	-1.8	-1.3	0.8
Impedance of leg (left)	3.5	17.2	24.5	5.0	3.6	-3.8
Leg predicted mass (left)	2.7	14.4	21.5	-4.6	-3.7	2.8
Trunk fat mass	0.0	0.2	0.4	0.1	-0.0	-0.7
Waist circumference	0.2	0.8	2.0	-1.4	-0.7	-0.0
Number of incorrect matches in round	0.5	0.8	1.8	0.2	0.8	1.3
Past tobacco smoking	0.1	0.1	0.2	-0.4	0.2	0.4
Alcohol usually taken with meals	0.2	0.3	0.4	0.5	-0.5	0.6
Nervous feelings	1.8	3.4	6.6	1.2	1.5	-2.6
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	1.7	-0.3	1.3	-1.1
Hearing difficulty/problems with background noise	0.2	0.3	0.6	0.4	0.8	-0.5
Hair/balding pattern: Pattern 2	2.0	2.5	4.0	0.2	1.9	-2.0
Had menopause	0.8	1.0	1.4	0.8	1.0	-1.2
Had other major operations	1.5	1.9	3.4	1.9	1.0	-1.1
Forced vital capacity (FVC)	0.1	0.2	0.6	-0.2	-0.8	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.4	6.4	2.5	0.6	0.8
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.2	0.6	-0.2	-1.5
Qualifications: None of the above	0.3	0.6	1.3	-0.3	-1.1	-0.8
Financial difficulties in last 2 years	0.1	0.2	0.4	0.0	0.6	-0.3
Mouth/teeth dental problems	1.5	2.2	6.6	-0.3	0.1	2.6
Heart attack	2.2	2.8	3.8	-1.9	-1.3	1.7
Allergy	0.3	0.7	1.0	0.9	1.0	0.6
Pain all over the body in last month	1.0	1.0	2.7	-0.5	-0.2	1.7
Diabetes (self-reported)	0.9	1.4	2.9	0.1	1.2	-1.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.3	0.2	1.1	-0.1
Medication: Ramipril	0.5	0.6	0.9	-0.9	-0.8	-0.5
Medication: Simvastatin	1.9	2.8	3.6	-1.9	-1.2	-1.9
Fluid intelligence score	0.3	0.5	0.9	-0.9	-0.8	-0.2
Illnesses of siblings	0.2	0.3	0.7	0.1	-0.8	0.4
Neuroticism score	1.6	3.3	8.9	0.8	0.7	-3.0
Weight	1.1	5.4	9.1	-3.0	-2.3	1.4
Impedance of arm (right)	2.9	13.3	21.6	4.6	3.2	-2.8
Arm fat percentage (right)	0.1	0.2	0.4	0.4	0.1	-0.6
Trunk fat-free mass	3.9	22.3	38.4	-6.2	-4.3	3.1
Hip circumference	1.7	7.4	13.4	-3.7	-2.4	1.7
Time employed in main current job	1.9	2.1	3.1	0.5	1.8	-1.7
Alcohol intake versus 10 years previously	5.6	8.3	14.1	-2.3	-3.8	2.3
Father’s age at death	0.4	0.6	1.5	-0.2	1.2	-0.4
Worrier / anxious feelings	1.6	2.9	3.4	1.6	1.7	-1.9
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.3	-1.5	-1.1	-1.2
Falls in the last year	1.0	1.4	4.0	-0.3	-0.1	-2.0
Hair/balding pattern: Pattern 3	3.3	4.9	9.6	0.3	-2.2	3.1
Number of live births	0.0	0.0	0.0	-0.2	0.0	0.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	0.7	0.8	-0.8	-0.4
Pulse rate	3.3	5.5	8.1	2.8	2.6	-1.3
Happiness	1.7	2.1	4.9	1.1	2.2	-0.4
Noisy workplace	1.5	1.8	4.2	-0.9	-0.7	2.0
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.7	-0.9	0.7	-0.5
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	2.7	-0.2	1.6	-1.6
Mouth/teeth dental problems: Dentures	0.7	1.2	1.5	-0.9	-1.2	-1.2
Asthma	0.7	1.4	2.5	-1.0	-1.6	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	0.9	0.8	1.0	0.5
Medication: Cholesterol lowering	2.2	3.5	6.0	-2.5	-1.3	-1.6
Depression (self-reported)	1.6	2.0	4.0	-0.5	1.3	-2.0
Medication: Lansoprazole	0.4	0.5	0.9	0.1	0.7	-1.0
Prospective memory result	0.3	0.3	0.6	-0.0	-0.6	0.8
Lung cancer (father)	1.0	1.1	2.3	1.5	1.0	0.4
Illnesses of mother	1.2	1.5	2.7	1.6	0.1	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.7	0.5	-1.3	0.5
Pulse wave Arterial Stiffness index	0.6	0.7	1.6	-1.3	-0.5	0.5
Impedance of arm (left)	3.2	14.9	27.2	5.2	3.2	-2.7
Arm fat mass (right)	0.3	1.2	2.1	-1.4	-1.1	0.3
Trunk predicted mass	3.8	21.8	37.7	-6.1	-4.3	3.0
Standing height	0.7	6.6	11.0	-3.3	-2.6	1.5
Length of working week for main job	1.2	1.3	2.2	-0.7	-1.5	-1.0
Exposure to tobacco smoke at home	1.0	1.1	2.1	-0.1	-1.5	1.1
Breastfed as a baby	1.4	1.8	2.9	1.7	0.1	1.6
Tense / ‘highly strung’	0.8	1.3	2.4	-1.1	-0.6	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.3	-1.5	-0.7	-0.6
Hair/balding pattern: Pattern 4	0.2	0.5	1.0	-1.0	-0.7	-0.1
Birth weight of first child	0.9	1.7	3.1	0.7	1.8	-1.2
Peak expiratory flow (PEF)	0.6	1.3	3.6	1.9	-0.2	-0.6
Pulse wave reflection index	1.3	1.6	3.4	-1.8	-1.1	-0.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.4	1.2	-0.3	0.8
Loud music exposure frequency	2.2	2.4	4.1	-1.1	-2.0	1.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.9	-0.5	-0.3	1.4
Mouth/teeth dental problems: Bleeding gums	2.2	2.9	6.8	0.4	1.3	-2.6
Blood clot in the leg (DVT)	0.5	0.6	1.7	0.2	1.3	-0.3
Medication: Paracetamol	3.5	5.8	7.5	2.7	2.7	-1.6
Headache pain in last month	2.6	4.5	6.5	2.1	1.6	-2.5
Medication for cholesterol, blood pressure or diabetes	2.1	3.4	6.5	2.5	1.9	0.2
Glaucoma (self-reported)	1.3	1.5	2.5	1.0	-0.9	1.6
Gout (self-reported)	3.0	4.1	7.8	-0.5	-2.0	2.8
Hypothyroidism/myxoedema (self-reported)	2.4	4.7	7.5	-2.7	-2.5	0.5
Medication: Amlodipine	0.2	0.3	0.6	0.8	-0.2	-0.5
Medication: Ventolin 100micrograms inhaler	1.3	1.6	2.5	1.6	1.2	-1.0
Birth weight	1.8	3.9	8.2	-0.1	2.9	-1.9
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	-0.4	-0.2	0.1
High blood pressure (siblings)	0.0	0.0	0.0	0.0	-0.0	-0.1
Forced vital capacity (FVC), Best measure	0.2	0.9	2.3	-0.5	-1.5	0.4
Body fat percentage	0.4	1.6	2.3	1.5	0.8	-1.4
Leg fat percentage (right)	0.2	0.8	2.0	0.7	0.2	-1.4
Arm fat-free mass (right)	3.0	15.2	25.1	-5.0	-3.7	2.5
Exposure to tobacco smoke outside home	0.7	0.9	1.8	-0.4	-1.4	-0.8
Comparative body size at age 10	2.8	7.7	17.2	-4.2	-1.9	1.5
Number of full brothers	0.9	1.1	2.2	0.1	1.5	-1.1
Worry too long after embarrassment	4.3	7.3	11.0	2.4	2.3	-3.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	-0.2	-0.7	0.4
Wheeze or whistling in the chest in last year	1.6	2.8	3.9	-2.0	-1.8	-1.1
Number of children fathered	1.8	2.1	4.3	2.1	0.7	1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.7	1.9	4.8	2.2	1.0	-0.2
Age at first live birth	0.6	1.1	2.5	-0.8	-0.4	1.6
Pulse wave peak to peak time	0.4	0.5	1.2	1.1	0.3	-0.4
Health satisfaction	0.9	1.1	2.4	0.2	1.0	-1.5
Shortness of breath walking on level ground	0.5	0.6	0.7	0.8	0.8	-0.7
Qualifications: College or University degree	1.9	5.9	9.3	0.6	3.0	-2.9
Eye problems/disorders: None of the above	0.6	0.7	1.0	-0.2	-1.0	0.9
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.5	0.7	-0.6	-1.2
Emphysema/chronic bronchitis	0.5	0.6	1.6	-0.3	-1.3	0.2
Medication for pain relief, constipation, heartburn	0.2	0.4	0.7	-0.6	-0.9	0.3
Neck or shoulder pain in last month	0.4	0.5	0.9	1.0	0.2	-0.8
Medication: Blood pressure	1.3	2.2	4.5	-2.1	-1.3	0.7
Angina (self-reported)	2.1	2.8	4.3	-1.8	-2.1	1.0
Migraine (self-reported)	1.4	1.8	4.8	-0.7	0.3	-2.2
Medication: Ibuprofen	0.2	0.3	0.5	0.4	0.7	0.4
Medication: Allopurinol	1.1	1.5	2.6	0.6	-1.2	1.6
Medication: Omeprazole	0.2	0.3	0.7	0.8	0.4	0.2
Medication: Seretide 50 evohaler	0.7	0.8	1.8	0.8	1.4	0.1
Mean time to correctly identify matches	0.2	0.3	0.6	0.8	-0.3	0.5
Heart disease (mother)	0.6	0.7	1.5	-0.7	-0.5	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	6.4	1.0	2.5	0.0
Whole body fat mass	0.0	0.2	0.3	-0.4	-0.6	-0.1
Leg fat mass (right)	0.3	1.1	1.7	-1.2	-1.3	-0.0
Arm predicted mass (right)	3.0	15.6	26.0	-5.1	-3.8	2.5
Pulse rate, automated reading	3.3	10.7	13.0	3.4	3.6	-2.7
Alcohol intake frequency.	0.1	0.2	0.2	-0.5	-0.3	-0.5
Comparative height size at age 10	0.6	3.3	6.7	-1.5	-1.0	2.6
Number of full sisters	1.0	1.2	2.7	-0.9	0.2	-1.6
Suffer from ‘nerves’	0.9	1.4	2.0	1.0	1.4	-1.0
Overall health rating	1.0	2.3	6.2	-0.6	0.4	-2.5
Chest pain or discomfort	0.8	1.2	3.2	-0.4	-0.5	-1.8
Had major operations	0.1	0.1	0.2	0.4	-0.0	-0.4
Age at last live birth	2.0	3.0	6.8	-0.8	-1.2	2.6
Family relationship satisfaction	0.4	0.5	0.8	0.9	0.7	-0.4
Leg pain on walking	0.6	0.7	1.2	-0.7	-1.1	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.7	0.1	-0.4	-0.8
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.3	1.1	1.5	-0.2
Illness, injury, bereavement, stress in last 2 years	2.1	2.5	5.7	0.4	-1.3	2.4
Medication: Aspirin	1.0	1.4	3.0	-1.7	-0.7	-0.8
Supplements: Vitamin C	0.4	0.5	0.7	0.6	0.8	0.5
Knee pain experienced in last month	1.3	2.0	3.7	1.9	1.3	-0.7
Hypertension (Self-reported)	1.2	3.2	5.2	-2.0	-2.3	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	0.2	0.3	-0.4
Illnesses of father: Heart disease	0.9	1.2	1.5	-1.2	0.8	-1.2
Illnesses of siblings: Diabetes	0.7	0.8	1.4	1.2	1.0	0.2
Smoking status: Previous	0.2	0.4	0.7	0.8	-0.3	0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	5.8	-2.4	-2.1	0.6
Whole body fat-free mass	3.4	19.5	32.4	-5.7	-4.1	3.1
Leg fat-free mass (right)	2.8	15.2	20.7	-4.5	-3.8	3.2
Arm fat percentage (left)	0.1	0.3	0.6	0.8	-0.0	-0.6
Average weekly red wine intake	0.6	0.9	2.2	-1.5	-0.7	-0.3
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.6	-0.2	0.1	-0.8
Mood swings	0.4	0.7	1.0	-1.0	-0.9	-0.6
Loneliness, isolation	1.0	1.3	2.0	0.5	-1.4	1.3
Long-standing illness, disability or infirmity	1.3	2.0	2.4	-1.4	-1.6	-1.3
Ever had bowel cancer screening	0.2	0.3	0.5	0.4	-0.7	-0.3
Diabetes diagnosed by doctor	0.5	0.9	1.9	-0.9	-0.0	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.3	0.3	-0.5	1.1
Friendships satisfaction	3.0	3.7	8.5	1.5	2.9	-0.5
Qualifications: nursing, teaching	0.6	0.9	1.6	1.0	1.3	-0.0
Commuting to job workplace: Walk	2.2	2.4	6.0	-2.4	-1.0	0.4
Eye problems/disorders: Cataract	0.1	0.2	0.4	0.3	0.6	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.8	1.7	-0.0	-0.4
Medication for cholesterol	0.6	1.0	2.0	0.8	1.4	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	-0.5	0.5	0.3
Back pain experienced in last month	2.3	3.3	4.2	2.1	2.0	-1.3
Mineral and other dietary supplements	0.5	0.7	1.2	-1.1	-0.0	-1.0
Breast cancer (self-reported)	0.6	0.7	2.1	1.4	-0.3	0.2
Asthma (self-reported)	0.6	1.1	1.9	-0.9	-1.4	-0.8
Osteoporosis (self-reported)	1.7	2.2	4.0	-1.6	-2.0	-0.1
Osteoarthritis (self-reported)	2.1	2.7	6.9	2.6	1.1	-0.0
Medication: Aspirin	0.5	0.7	1.1	-1.1	-0.1	-0.9
Medication: Gliclazide	0.2	0.2	0.4	0.6	-0.5	0.2
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	1.2	-0.1	0.4
Smoking status: Current	0.3	0.5	0.8	-0.9	0.2	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	3.8	1.9	0.5	0.1
Whole body water mass	3.6	20.6	34.0	-5.8	-4.2	3.2
Leg predicted mass (right)	2.7	14.5	20.2	-4.5	-3.7	3.1
Arm fat mass (left)	0.2	0.9	1.5	-1.2	-1.1	0.3
Number of self-reported non-cancer illnesses	1.1	1.9	5.0	-0.5	0.6	-2.2
Average weekly champagne plus white wine intake	1.1	1.6	2.9	-0.2	-1.7	1.3
Miserableness	0.2	0.3	0.5	0.1	-0.7	-0.7
Guilty feelings	2.0	3.1	7.6	-1.2	0.1	-2.8
Wears glasses or contact lenses	2.2	2.5	3.9	2.0	1.5	-1.2
Ever taken oral contraceptive pill	1.3	1.4	3.4	-0.1	-0.9	-1.8
Hearing aid user	0.2	0.3	0.6	-0.8	-0.3	0.2
Mother’s age at death	0.4	0.6	1.6	-0.2	0.2	1.3
Financial situation satisfaction	0.4	0.5	1.1	-1.0	-0.5	0.4
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.6	0.8	-0.2	0.8
Commuting to job workplace: Public transport	0.3	0.4	0.6	0.6	0.8	-0.2
Eye problems/disorders: Glaucoma	1.6	1.9	3.2	1.1	-1.1	1.8
Medication: Blood pressure	1.2	2.3	4.3	-1.2	-2.1	1.1
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	-0.1	-0.2	-0.1
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.0	0.5	-0.9	1.0
High cholesterol (Self-reported)	0.8	1.3	2.9	-1.7	-0.4	-1.0
Medication: Bendroflumethiazide	1.2	1.8	2.8	-1.6	-1.7	0.3
Medication: Paracetamol	4.6	7.1	10.3	3.2	2.7	-1.9
Medication: Lisinopril	0.9	1.2	3.1	-0.1	-1.8	0.7
Medication: Atorvastatin	0.4	0.5	1.0	-0.1	-1.0	0.8
Illnesses of father: High blood pressure	0.9	1.2	3.3	-1.8	-0.0	0.4
Alcohol drinker status: Never	0.4	0.4	1.0	-1.0	-0.4	0.2
Ever smoked	0.2	0.3	0.7	-0.4	-0.4	-0.8
Basal metabolic rate	2.9	16.2	26.3	-5.1	-3.8	2.8
Leg fat percentage (left)	0.2	0.8	1.3	1.0	0.2	-1.1
Arm fat-free mass (left)	3.3	16.6	30.9	-5.6	-3.7	2.3
Number of operations (self-reported)	1.5	2.3	4.8	1.1	1.0	-2.2
Average weekly beer plus cider intake	0.5	0.7	1.8	1.4	0.4	0.3
Irritability	0.8	1.4	4.1	-0.2	-0.4	-2.0
Risk taking	1.1	1.5	3.4	-1.8	-1.1	-0.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	-0.1	0.6	0.0
Fractured/broken bones in last 5 years	1.8	2.4	6.5	-0.3	0.7	-2.5
Age started oral contraceptive pill	0.7	0.8	2.4	0.0	0.3	-1.6
Diastolic blood pressure, automated reading	0.7	2.3	5.6	1.0	-0.5	2.4
Ever depressed for a whole week	0.7	0.9	2.7	-0.1	0.3	-1.6
Unable to work because of sickness or disability	0.4	0.5	1.0	-0.2	0.8	-1.0
Commuting to job workplace: Cycle	0.1	0.2	0.4	-0.0	-0.1	-0.7
Myopia	0.7	1.0	2.1	1.4	0.6	-0.6
Vascular/heart problems diagnosed by doctor	1.9	5.1	8.5	2.4	2.9	-1.2
Cholesterol lowering medication	0.2	0.2	0.6	-0.7	-0.4	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.9	1.0	-0.1	0.0
Pain experienced in last month	2.5	4.1	6.1	-1.9	-1.6	2.5
Supplements: Calcium	1.2	1.3	2.8	0.2	1.1	-1.7
Basal cell carcinoma (self-reported)	0.5	0.6	0.9	-0.9	-0.3	-0.9
Heart attack/myocardial infarction (self-reported)	1.6	2.1	3.1	-1.5	-1.0	1.8
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.2	0.7	1.5	-0.3
Heart disease (siblings)	0.5	0.6	0.9	-0.9	-0.2	0.9
Alcohol drinker status: Previous	1.5	1.7	4.4	0.2	0.8	-2.1
Pack years of smoking	1.4	2.1	4.3	-2.1	-1.4	-0.2
Impedance of whole body	4.3	22.0	33.2	5.8	4.1	-4.0
Leg fat mass (left)	0.2	0.8	1.5	-1.0	-1.2	0.1
Arm predicted mass (left)	3.0	15.0	29.2	-5.4	-3.4	2.0