Hub : Genes

SBF2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.4730	0.1220	3.1e-03	0.025	NA	0.153	NA	0.039	5.0e-02	NA	1.1e-05	NA	2.0e-02
2	GTEx	Cells Transformed fibroblasts	0.1560	0.0460	3.8e-06	0.136	NA	0.124	NA	0.143	2.3e-10	NA	1.5e-09	NA	6.8e-11
3	GTEx	Prostate	0.2110	0.0870	4.4e-03	0.045	NA	-0.005	NA	0.028	2.8e-02	NA	4.4e-01	NA	6.7e-02
4	GTEx	Testis	0.1030	0.0460	9.3e-03	0.012	NA	0.000	NA	0.018	8.9e-02	NA	3.0e-01	NA	5.0e-02
5	GTEx	Thyroid	0.1110	0.0420	1.5e-03	0.015	NA	0.066	NA	0.021	2.4e-02	NA	8.3e-06	NA	9.6e-03
6	NTR	Blood	0.0219	0.0088	1.1e-03	0.001	0.007	0.005	0.007	0.003	1.0e-01	0.002	6.7e-03	0.0018	2.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.7	1.1	2.1	0.3	-0.7	1.3	-1.0	-1.4	-1.2
Bipolar Disorder or Schizophrenia	0.2	0.5	1.5	-0.2	0.3	0.6	-0.5	-1.2	-0.8
Depressed Affect (Nagel 2018)	1.9	3.9	10.2	-1.4	1.7	-3.2	2.7	0.8	-0.3
Depression (Nagel 2018)	3.0	4.5	9.4	-3.1	1.3	-2.6	2.3	1.2	-1.6
Intelligence (Savage-Jansen 2018)	0.5	1.6	4.1	0.5	0.9	-0.7	0.5	-2.0	-1.9
Neuroticism (Nagel 2018)	5.0	11.7	25.8	-2.9	3.3	-5.1	4.8	1.1	1.0
Schizophrenia (2018)	0.1	0.3	0.9	-0.6	0.9	-0.3	0.2	-0.4	-0.1
Schizophrenia vs Biploar Disorder	0.2	0.2	0.6	-0.6	-0.2	-0.3	0.6	0.2	0.8
Worry (Nagel 2018)	4.7	9.9	19.4	-3.3	2.9	-4.4	4.2	1.1	1.2
Alzheimer’s Disease (in mother)	0.4	0.5	1.9	-0.3	0.3	-0.4	0.2	0.6	1.4
Alzheimer’s Disease (in father)	0.9	1.0	2.4	1.0	1.6	-0.8	1.1	-0.5	0.5
Alzheimer’s Disease (including proxy)	0.6	0.9	3.8	0.2	1.1	-0.4	0.3	0.2	1.9
Crohns Disease (2017)	1.1	2.5	7.8	-0.3	1.1	-0.5	0.4	2.8	2.3
Irritable Bowel Disease (IBD)	0.1	0.3	0.9	0.0	1.0	0.0	-0.2	0.8	0.1
Ulcerative Colitis (UC)	0.3	0.6	1.8	0.3	0.8	-0.0	-0.2	-0.9	-1.4
Major Depression (MDD)	0.4	0.5	2.4	0.2	0.4	0.4	-0.2	-0.1	-1.6
Reaction Time	0.7	1.3	5.1	-0.5	0.5	-0.6	0.5	-1.3	-2.3
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.4	0.6	0.5	-0.7	0.4	-0.8	-1.8
Breast Cancer	3.3	8.0	16.5	-0.4	-0.8	4.1	-4.1	-2.6	-2.8
Ovarian Cancer	0.5	0.7	2.5	1.6	0.4	-0.5	0.5	1.0	-0.2
Prostate Cancer	3.0	4.2	8.9	0.0	2.6	-3.0	2.7	0.7	1.3
Age at First Birth	0.5	0.7	3.3	-0.5	-1.8	-0.1	0.0	0.4	-0.8
Bipolar Disorder (2011)	1.0	1.0	2.3	-1.2	-0.6	1.0	-0.6	-0.4	-1.5
Body Mass Index (BMI) (2010)	0.4	0.5	1.7	0.2	-1.3	0.3	0.2	-0.5	1.0
Coronary Artery Disease (CAD)	0.1	0.1	0.4	0.2	-0.1	-0.3	0.4	-0.6	-0.3
Crohns Disease (2012)	0.6	0.9	2.5	0.9	0.2	0.4	-0.3	1.6	1.3
Mean Putamen Volume	0.9	1.0	3.6	-0.1	-1.9	0.8	-0.6	-1.0	-0.4
Fasting Glucose	0.6	0.7	1.3	-1.1	-1.1	-0.7	0.9	0.7	-0.3
HbA1C	4.3	4.8	10.1	0.9	3.2	-1.9	2.1	0.9	3.0
HDL Cholesterol	1.7	2.9	5.4	-0.1	1.1	-2.3	2.2	1.8	1.6
LDL Cholesterol	0.7	1.2	2.6	-0.3	0.8	1.6	-1.3	-0.5	-1.3
Lupus	0.5	0.7	1.2	-0.7	0.5	1.0	-1.1	-0.8	-0.8
Neuroticism (2016)	7.5	10.9	27.2	0.8	2.3	-4.8	5.2	0.9	2.9
Primary Biliary Cirrhosis	0.5	0.7	2.9	1.7	0.9	0.2	0.1	0.8	-0.3
Rheumatoid Arthritis	3.0	4.1	7.9	1.0	-2.4	2.8	-2.5	-0.6	-1.9
Schizophrenia (2014)	0.1	0.3	0.7	-0.8	0.4	0.4	-0.4	-0.6	-0.2
Triglycerides	1.0	1.6	3.5	0.1	-1.5	1.5	-1.0	-0.9	-1.9
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.1	0.5	-1.1	-0.6	0.5	0.5	-0.3
Ulcerative Colitis	0.9	1.4	3.4	-0.0	0.5	0.7	-1.1	-1.8	-1.7
Blood Eosinophil Count	0.3	2.4	5.8	-0.5	0.3	1.9	-2.2	0.1	-2.4
Blood Platelet Count	0.1	0.6	3.0	0.4	1.7	-0.3	0.4	0.1	0.6
Blood Red Count	6.2	59.7	174.2	0.8	-3.4	12.7	-13.2	-1.9	2.7
Blood White Count	0.8	6.2	27.7	-0.3	0.4	1.7	-1.5	-2.0	-5.3
Heel T-Score	0.6	4.5	8.1	-1.7	2.8	-2.8	2.4	0.9	1.4
BMI	0.2	1.0	3.2	1.0	-0.5	0.1	0.1	-1.8	-1.3
Height	1.2	23.9	66.1	2.3	0.6	7.5	-8.1	-3.5	-1.8
Waist Hip Ratio (WHR)	7.2	32.5	69.4	-0.6	5.6	-8.3	7.6	4.2	4.3
Systolic Blood Pressure	2.8	14.2	28.0	-0.1	-4.0	-3.9	5.1	-5.3	0.3
Smoking Status	0.2	0.6	1.9	0.3	1.2	-0.2	0.1	1.4	-0.1
Allergy or Eczema	1.3	3.4	6.5	-1.7	1.6	-2.6	2.1	0.1	-2.1
Cardiovascular Disease	1.6	5.2	10.1	-1.5	-2.5	-2.0	2.1	-3.2	-2.0
Hypothyroidism (self reported)	0.8	1.9	3.4	1.0	-1.8	1.8	-1.6	-1.1	-0.4
Respiratory disease	0.2	0.4	0.8	0.4	0.5	-0.8	0.9	-0.8	0.5
Type 2 Diabetes (T2D) (2018)	1.0	1.9	4.0	-0.9	0.9	-2.0	1.8	1.5	-0.3
Lung FEV1/FVC ratio	2.9	14.7	34.3	1.3	4.2	-5.8	5.9	0.7	-0.7
Lung FVC	0.2	1.2	3.1	0.7	-1.8	1.4	-0.9	-0.3	-1.0
Neuroticism	5.0	12.1	26.5	-1.7	4.5	-5.1	4.7	1.0	0.9
Chronotype (morning person)	0.5	1.2	1.6	-0.9	-0.7	1.2	-1.2	-1.1	-1.3
Hair Pigment	0.6	17.5	46.5	0.0	-3.2	6.8	-6.8	-0.8	-1.4
Tanning	0.2	2.4	7.0	0.3	0.5	-2.1	2.6	-0.6	1.6
Hand grip strength (left)	1.3	3.3	9.0	0.2	-0.9	3.0	-2.9	-1.1	-0.4
Number of treatments/medications taken	0.3	0.6	0.9	-0.8	0.3	-1.0	0.8	-0.8	-0.7
Average weekly spirits intake	0.6	0.8	2.6	-0.9	-1.6	-0.5	1.0	-0.2	-0.1
Sensitivity / hurt feelings	2.8	4.8	10.3	-0.9	3.2	-2.9	2.9	0.5	1.0
Frequency of depressed mood in last 2 weeks	1.7	2.4	5.3	-2.3	0.9	-1.8	1.8	0.5	-1.3
Hearing difficulty/problems: Yes	1.2	1.8	3.3	0.9	-0.0	1.8	-1.7	-1.7	-1.1
Relative age of first facial hair	2.2	4.6	7.8	2.0	-1.1	2.6	-2.6	-2.8	-1.2
Other serious medical condition/disability diagnosed by doctor	3.7	4.8	7.9	-1.8	2.8	-2.8	2.5	1.5	1.3
Ever used hormone-replacement therapy (HRT)	0.8	1.1	3.8	-0.2	1.0	0.8	-1.0	0.0	2.0
Ever had hysterectomy (womb removed)	2.2	2.5	6.0	0.1	0.6	-2.3	2.4	0.1	1.9
Systolic blood pressure, automated reading	3.1	9.0	19.8	0.2	-2.9	-3.5	4.5	-2.7	2.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.0	-0.5	-0.3	0.4	0.5	-0.2
Angina	0.7	0.9	1.7	-1.3	0.2	-0.5	0.5	1.2	-1.3
Medication for hormone replacement therapy	0.9	1.0	2.2	0.4	-0.7	1.5	-1.5	-0.1	0.8
Vitamin and mineral supplements	1.1	1.4	2.2	-1.4	1.2	-1.0	1.1	0.9	1.5
Supplements: Zinc	0.8	0.9	3.5	0.5	-0.3	0.6	-1.0	-0.1	-1.9
Medication: Co-codamol	0.4	0.4	1.2	-0.4	1.1	-0.7	0.7	-0.4	0.1
Medication: Metformin	0.1	0.2	0.5	-0.1	-0.2	-0.1	0.1	-0.7	-0.7
Diabetes (father)	1.2	1.5	2.7	-1.4	0.6	-1.5	1.3	1.6	0.1
Diabetes (mother)	0.6	0.8	2.0	-0.3	0.3	-1.4	1.3	0.9	-0.1
Severe depression (siblings)	1.1	1.3	3.4	1.2	-0.6	-0.5	0.9	-1.8	-1.2
Pack years adult smoking proportion	0.7	1.1	3.3	-0.8	-0.5	0.6	-0.5	-1.8	-1.3
Impedance of leg (right)	4.7	22.9	49.8	-1.4	6.6	-7.1	5.8	2.1	2.1
Leg fat-free mass (left)	2.1	11.1	24.2	2.4	-2.7	4.9	-4.4	-2.5	-2.0
Trunk fat percentage	3.2	12.8	31.5	0.7	4.0	-5.6	5.2	0.9	0.9
Hand grip strength (right)	1.0	2.6	6.7	-1.1	-1.2	2.6	-2.4	-0.8	-0.1
Townsend deprivation index at recruitment	2.2	3.0	4.8	0.3	1.9	-2.1	2.2	1.7	1.6
Current tobacco smoking	0.5	0.7	3.7	-0.0	1.9	-0.6	0.6	0.2	-0.1
Average weekly fortified wine intake	0.6	0.8	2.4	-1.6	0.8	-0.0	-0.2	-0.6	1.1
Maternal smoking around birth	0.4	0.6	1.4	0.2	0.4	-0.9	1.1	0.3	1.2
Fed-up feelings	1.1	1.9	4.2	-0.0	2.0	-2.1	1.8	0.3	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	3.9	-2.0	1.3	-1.7	1.6	0.5	-0.2
Relative age voice broke	1.9	2.9	7.0	0.4	0.0	2.4	-2.6	-2.1	-0.3
Taking other prescription medications	1.2	1.9	5.2	-1.0	1.1	-2.3	2.0	0.0	-0.0
Age when periods started (menarche)	0.4	1.0	2.5	0.3	-1.1	-0.2	0.4	-1.4	-1.6
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.8	0.6	1.4	-1.1	1.1	0.2	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	4.8	1.6	2.2	-1.2	0.9	0.5	1.2
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	4.5	0.4	-0.5	0.5	-0.3	-2.1	-2.1
Qualifications: CSEs or equivalent	0.3	0.4	1.3	0.0	0.3	-0.8	0.6	1.2	-0.4
Serious illness, injury or assault to yourself	0.9	1.1	2.0	-0.9	-0.2	-1.0	1.1	1.4	1.1
High blood pressure	1.3	3.6	9.3	-0.1	-1.7	-2.7	3.0	-1.4	-0.1
Hayfever, allergic rhinitis or eczema	1.3	2.8	5.1	-1.3	1.8	-2.1	1.5	0.3	-2.3
Multivitamins +/- minerals	0.6	0.8	2.0	1.4	-0.8	0.3	-0.2	-0.7	-1.2
Stomach or abdominal pain in last month	0.3	0.3	1.2	-0.1	0.6	-0.1	0.2	-0.7	1.1
Supplements: Glucosamine	0.5	0.6	1.2	0.5	0.9	0.7	-1.1	-0.4	0.9
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.0	0.7	1.7	-1.4	1.1	-0.3	-0.3
Medication: Atenolol	0.1	0.2	0.4	-0.3	-0.5	-0.4	0.7	0.2	-0.3
Medication: Levothyroxine sodium	0.1	0.1	0.3	-0.1	-0.2	0.5	-0.5	0.1	-0.3
Sitting height	1.7	12.0	22.3	3.9	0.5	4.4	-4.7	-3.0	-2.3
Chronic bronchitis/emphysema (father)	1.0	1.2	2.5	-0.9	0.6	-0.9	0.9	1.4	1.6
High blood pressure (mother)	0.3	0.5	0.7	0.6	-0.8	-0.6	0.7	-0.5	-0.9
Body mass index (BMI)	0.1	0.6	1.4	1.2	-0.4	-0.5	0.8	-0.8	-0.8
Impedance of leg (left)	4.2	20.5	46.0	-1.5	5.8	-6.8	5.7	2.0	2.2
Leg predicted mass (left)	2.1	11.1	24.2	2.3	-2.8	4.9	-4.4	-2.5	-2.0
Trunk fat mass	1.0	4.2	8.7	1.3	2.7	-3.0	2.7	-0.1	-0.0
Waist circumference	0.2	0.9	1.3	1.1	0.8	-1.1	1.0	-0.8	-0.7
Number of incorrect matches in round	0.3	0.5	1.1	-0.7	-1.1	0.7	-0.3	0.1	-0.8
Past tobacco smoking	0.3	0.6	0.9	0.9	-0.9	0.5	-0.4	-0.9	0.6
Alcohol usually taken with meals	0.8	1.3	3.4	-0.2	0.8	1.4	-1.8	-0.9	-0.8
Nervous feelings	4.9	9.1	22.9	-1.1	3.0	-4.8	4.5	0.9	0.8
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.4	-1.5	1.5	-1.4	1.5	0.7	0.2
Hearing difficulty/problems with background noise	0.5	0.8	2.2	1.4	1.5	0.0	-0.2	-0.8	-0.0
Hair/balding pattern: Pattern 2	0.9	1.1	2.5	0.3	0.0	-1.3	1.3	-1.6	-0.8
Had menopause	0.2	0.3	1.4	-0.2	-0.1	-0.1	-0.1	0.5	1.2
Had other major operations	1.2	1.5	3.0	-0.2	1.4	-1.4	0.8	1.3	1.7
Forced vital capacity (FVC)	0.5	1.9	5.8	2.4	-0.8	1.5	-1.2	-0.8	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	6.5	2.5	1.9	-1.3	1.2	1.1	0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.0	-0.6	1.0	-0.1	-0.2	0.1	0.6
Qualifications: None of the above	0.5	1.0	1.8	-0.6	1.0	1.3	-1.4	-0.4	-1.1
Financial difficulties in last 2 years	0.9	1.2	3.6	-1.9	0.6	-0.9	1.1	0.5	-1.0
Mouth/teeth dental problems	2.5	3.9	15.4	0.6	-3.9	2.2	-1.6	-0.1	-0.5
Heart attack	1.0	1.3	2.5	-1.1	-1.6	1.3	-1.2	-0.6	-0.6
Allergy	0.2	0.5	1.2	0.4	-0.9	1.1	-0.6	-0.3	0.7
Pain all over the body in last month	0.9	1.0	3.4	-0.5	-1.1	0.6	-1.0	0.2	-1.8
Diabetes (self-reported)	0.6	1.0	2.9	-0.2	-0.2	-1.5	1.7	0.4	0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.2	-1.1	-0.9	-0.5	0.3	0.2	0.2
Medication: Ramipril	0.5	0.6	1.4	1.2	-0.5	0.5	-0.3	-0.8	-1.1
Medication: Simvastatin	0.7	1.0	4.3	0.3	0.3	-0.4	-0.1	-2.1	-1.3
Fluid intelligence score	0.8	1.6	5.1	0.7	1.5	-0.6	0.2	-1.1	-2.3
Illnesses of siblings	0.2	0.3	0.5	-0.4	0.1	0.5	-0.7	0.7	0.6
Neuroticism score	4.7	9.8	22.1	-0.9	3.9	-4.7	4.4	0.2	1.0
Weight	0.6	2.7	4.5	2.1	-0.3	1.8	-1.7	-1.9	-1.5
Impedance of arm (right)	5.5	25.6	62.6	-0.8	4.8	-7.9	7.2	3.4	2.0
Arm fat percentage (right)	2.1	8.2	20.5	1.2	2.4	-4.5	4.5	0.8	0.3
Trunk fat-free mass	4.9	27.9	65.1	2.8	-3.6	8.1	-7.7	-3.6	-2.9
Hip circumference	2.0	8.6	12.5	2.0	-1.8	3.5	-3.3	-3.1	-3.5
Time employed in main current job	0.9	1.0	4.2	-0.3	0.5	-0.6	0.4	2.0	1.0
Alcohol intake versus 10 years previously	1.0	1.4	4.9	1.5	-2.2	0.9	-0.5	-0.6	-0.5
Father’s age at death	0.3	0.5	1.2	0.5	-0.2	1.1	-1.1	-0.4	-0.1
Worrier / anxious feelings	2.5	4.7	9.7	-1.8	2.3	-2.8	3.1	-0.7	1.2
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	4.2	-1.0	1.3	-2.1	1.9	1.9	0.0
Falls in the last year	2.2	3.0	7.2	-0.9	1.6	-2.7	2.6	0.9	0.0
Hair/balding pattern: Pattern 3	1.1	1.6	3.6	1.6	0.8	-1.7	1.9	0.3	0.3
Number of live births	0.6	0.8	2.7	-1.0	0.1	-0.7	1.0	1.7	0.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	5.3	2.3	0.7	-1.1	1.4	0.1	-0.8
Pulse rate	2.7	4.5	9.6	0.2	0.5	-2.3	2.2	2.7	3.1
Happiness	2.0	2.4	5.2	-1.9	-0.5	-2.0	2.3	0.4	1.1
Noisy workplace	0.6	0.8	1.6	-1.2	-1.3	0.9	-0.6	0.5	-0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	5.4	2.3	-0.5	0.5	-0.6	0.1	-0.2
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	3.8	-1.0	0.4	-1.4	1.3	1.2	1.9
Mouth/teeth dental problems: Dentures	0.8	1.3	4.6	1.0	2.1	-1.1	0.7	0.7	-0.4
Asthma	0.3	0.6	1.8	1.4	0.0	-0.0	0.1	-1.3	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.3	0.3	0.7	0.8	-1.1	1.0	0.6
Medication: Cholesterol lowering	0.6	0.9	2.9	0.3	-0.1	0.5	-0.6	-1.4	-1.7
Depression (self-reported)	0.6	0.7	2.5	0.3	1.3	0.1	-0.1	-1.6	0.4
Medication: Lansoprazole	0.5	0.6	1.3	-1.1	0.9	-0.4	0.4	0.0	1.1
Prospective memory result	0.3	0.4	0.6	-0.0	-0.6	0.8	-0.8	-0.8	-0.5
Lung cancer (father)	1.2	1.4	3.1	-0.1	-0.3	-1.4	1.8	0.6	1.7
Illnesses of mother	0.2	0.2	0.5	0.1	0.7	0.2	-0.6	0.1	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.2	1.5	0.1	-0.2	0.4	-0.1	-1.3
Pulse wave Arterial Stiffness index	1.6	1.9	6.4	-2.5	-0.9	-0.9	0.9	1.6	0.1
Impedance of arm (left)	5.2	24.0	58.0	-0.7	5.2	-7.6	7.0	2.7	1.7
Arm fat mass (right)	0.4	1.6	2.9	1.5	1.1	-1.6	1.7	-0.5	-0.7
Trunk predicted mass	4.8	27.5	64.6	2.7	-3.6	8.0	-7.7	-3.6	-2.8
Standing height	1.3	12.7	31.9	2.5	-0.0	5.2	-5.7	-2.7	-1.8
Length of working week for main job	0.4	0.5	1.7	-1.3	1.0	-0.1	-0.0	-0.3	0.2
Exposure to tobacco smoke at home	0.6	0.7	1.8	1.3	-0.7	0.9	-0.9	-0.2	-0.5
Breastfed as a baby	1.1	1.3	3.1	1.8	-0.2	-1.3	1.1	1.1	-0.8
Tense / ‘highly strung’	1.7	2.9	7.6	-0.7	1.1	-2.7	2.8	0.3	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.7	-1.6	0.5	-1.6	1.5	-0.2	1.1
Hair/balding pattern: Pattern 4	0.9	2.1	3.2	-1.4	1.4	-1.7	1.5	1.8	0.2
Birth weight of first child	1.2	2.2	7.7	2.8	1.2	1.0	-1.0	0.5	1.3
Peak expiratory flow (PEF)	2.1	4.9	8.8	1.3	2.7	-3.0	2.9	1.8	-0.7
Pulse wave reflection index	2.1	2.6	6.4	-1.9	0.1	-1.7	1.5	2.5	-0.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.2	-0.9	-0.5	-1.1	1.0	-0.4	0.4
Loud music exposure frequency	0.2	0.3	1.1	0.4	0.1	-0.4	0.3	0.3	-1.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.3	0.8	-1.1	-0.9	1.0	-0.7	-0.2
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	9.2	-0.8	3.0	-0.6	0.4	-0.5	1.8
Blood clot in the leg (DVT)	0.4	0.5	2.2	0.1	-0.1	0.4	-0.6	0.5	1.5
Medication: Paracetamol	1.7	2.8	4.4	-1.7	1.8	-2.1	1.8	1.7	0.5
Headache pain in last month	0.4	0.7	2.0	1.2	1.4	-0.1	0.0	-0.6	0.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.3	-0.0	0.4	0.5	-0.4	0.3	1.5
Glaucoma (self-reported)	1.1	1.3	5.0	-0.2	2.2	-1.0	1.0	-0.2	-0.8
Gout (self-reported)	1.5	2.1	10.0	1.3	-3.2	-0.4	0.7	-0.0	-0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.6	0.1	-1.6	0.9	-0.6	0.0	-0.1
Medication: Amlodipine	0.7	1.0	3.0	1.2	-0.1	-0.9	0.9	-1.7	0.2
Medication: Ventolin 100micrograms inhaler	1.5	1.9	4.0	0.5	1.9	-2.0	1.6	-0.9	0.2
Birth weight	2.1	4.7	11.2	0.9	0.7	2.8	-3.4	-1.7	-2.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.3	-1.1	-0.3	-0.5	0.7	1.0	1.1
High blood pressure (siblings)	0.7	1.0	2.5	1.1	-0.4	-1.4	1.6	-0.0	-0.5
Forced vital capacity (FVC), Best measure	0.6	2.1	3.5	1.5	-0.8	1.9	-1.7	-0.9	-1.6
Body fat percentage	3.2	12.6	31.1	0.7	3.8	-5.6	5.3	1.0	0.8
Leg fat percentage (right)	3.2	11.5	27.6	0.8	3.8	-5.2	4.9	1.2	0.7
Arm fat-free mass (right)	3.6	18.7	44.6	1.9	-2.9	6.7	-6.4	-3.1	-2.3
Exposure to tobacco smoke outside home	1.3	1.7	3.6	1.2	1.9	-1.6	1.2	-0.7	-1.0
Comparative body size at age 10	0.4	1.2	2.9	0.3	-1.6	1.1	-0.8	0.2	-1.7
Number of full brothers	0.6	0.8	2.7	0.3	-0.1	0.6	-0.7	-1.6	-1.0
Worry too long after embarrassment	4.1	6.9	13.5	0.6	3.7	-3.7	3.6	-0.0	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.8	0.3	-0.9	0.5	0.4	-0.1
Wheeze or whistling in the chest in last year	0.2	0.3	0.9	-0.1	0.7	-0.5	0.4	-0.2	-1.0
Number of children fathered	0.4	0.5	1.5	-1.2	-0.5	-0.1	-0.3	-0.3	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.8	-0.0	0.1	-0.4	0.3	-0.2	1.4
Age at first live birth	1.7	2.9	5.0	1.6	-1.9	2.2	-1.9	-1.6	-0.9
Pulse wave peak to peak time	2.1	2.5	7.0	2.6	1.1	1.2	-1.4	-1.9	-0.3
Health satisfaction	3.0	3.9	5.8	-2.4	2.2	-2.3	2.0	0.1	1.7
Shortness of breath walking on level ground	2.4	2.9	5.8	-0.9	1.7	-2.4	2.4	1.0	1.0
Qualifications: College or University degree	0.4	1.2	2.9	0.3	1.4	0.2	-0.7	-1.7	1.4
Eye problems/disorders: None of the above	1.9	2.1	4.5	0.6	-1.8	2.1	-2.0	-0.6	-0.8
Mouth/teeth dental problems: Loose teeth	1.3	1.6	3.3	-1.5	1.0	-1.8	1.5	0.2	-0.6
Emphysema/chronic bronchitis	0.6	0.7	1.5	-1.1	-0.6	1.1	-1.2	0.0	-0.0
Medication for pain relief, constipation, heartburn	0.2	0.3	1.3	0.1	-0.2	-0.2	0.1	-1.1	0.4
Neck or shoulder pain in last month	0.3	0.5	1.5	0.1	0.2	-0.3	0.6	-1.2	0.9
Medication: Blood pressure	0.2	0.3	0.5	-0.7	-0.6	0.0	0.3	0.4	-0.7
Angina (self-reported)	0.6	0.8	1.5	-1.1	0.4	-0.6	0.6	1.2	-1.2
Migraine (self-reported)	0.7	0.8	2.1	0.1	0.5	-1.2	1.1	1.5	0.1
Medication: Ibuprofen	0.6	0.7	1.8	-0.5	0.6	1.0	-1.3	0.8	-0.5
Medication: Allopurinol	0.9	1.2	5.4	0.5	-2.3	-0.5	0.9	-0.6	-0.2
Medication: Omeprazole	0.6	0.7	3.6	-0.5	0.7	-0.2	0.3	0.0	1.9
Medication: Seretide 50 evohaler	0.1	0.2	0.4	0.1	-0.4	0.3	-0.4	-0.6	0.4
Mean time to correctly identify matches	0.2	0.4	1.9	-0.5	0.2	-0.3	0.3	-0.5	-1.4
Heart disease (mother)	1.9	2.3	6.3	0.6	0.4	-2.3	2.5	1.2	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.5	-0.5	-1.2	-0.8	1.2	-0.3	1.2
Whole body fat mass	0.7	3.0	6.5	1.1	2.0	-2.5	2.4	-0.4	-0.3
Leg fat mass (right)	0.6	2.4	5.3	1.2	1.8	-2.3	2.2	-0.1	-0.5
Arm predicted mass (right)	3.6	18.2	42.8	2.1	-2.8	6.5	-6.2	-3.2	-2.3
Pulse rate, automated reading	4.2	13.6	21.6	1.7	2.1	-4.7	4.4	4.5	3.6
Alcohol intake frequency.	0.4	1.0	2.8	0.9	-0.1	1.6	-1.7	-0.1	-0.1
Comparative height size at age 10	0.4	2.0	4.4	1.7	-0.0	2.1	-2.0	-0.2	0.5
Number of full sisters	1.2	1.5	4.3	0.7	1.8	-0.1	-0.2	1.0	-2.1
Suffer from ‘nerves’	3.2	5.1	9.9	-1.6	2.4	-3.1	2.9	1.2	1.7
Overall health rating	1.5	3.3	6.0	-2.5	1.4	-2.2	1.9	1.2	1.4
Chest pain or discomfort	0.9	1.3	3.0	-0.5	0.8	-1.6	1.7	-1.2	-0.1
Had major operations	1.4	1.7	3.3	-1.4	0.8	-1.5	1.8	1.0	0.8
Age at last live birth	0.6	0.9	2.3	0.9	-1.1	0.6	-0.4	-0.7	-1.5
Family relationship satisfaction	0.8	1.0	2.7	-1.6	-0.6	-0.5	0.5	-1.3	0.7
Leg pain on walking	0.6	0.7	1.9	0.5	0.8	0.3	-0.2	-1.2	-1.4
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.5	3.8	0.4	1.7	-1.6	1.6	2.0	1.7
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.2	-0.7	0.3	-1.0	0.4	1.8	-0.7
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	7.5	2.7	-0.8	0.2	-0.2	-0.8	-0.3
Medication: Aspirin	0.4	0.5	1.8	-0.5	-0.6	-0.2	0.5	-0.7	-1.3
Supplements: Vitamin C	0.1	0.1	0.2	0.5	-0.0	0.1	-0.1	0.5	-0.2
Knee pain experienced in last month	0.8	1.2	2.7	0.0	1.0	-1.6	1.2	1.0	1.1
Hypertension (Self-reported)	1.3	3.7	9.2	-1.0	-1.5	-2.7	3.0	-1.5	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.0	-1.0	0.9	0.1	0.1	-0.8	0.9
Illnesses of father: Heart disease	0.9	1.3	2.7	-1.7	-0.1	0.6	-0.4	1.5	1.4
Illnesses of siblings: Diabetes	1.9	2.3	4.3	-0.4	1.7	-1.8	2.1	0.5	1.7
Smoking status: Previous	0.2	0.3	1.3	-0.4	-0.1	-0.2	0.4	1.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	6.9	-0.1	-1.2	2.4	-2.6	0.4	1.0
Whole body fat-free mass	3.9	22.3	51.7	2.6	-3.5	7.2	-6.8	-3.4	-2.5
Leg fat-free mass (right)	2.6	13.8	30.7	2.3	-3.5	5.5	-4.9	-2.6	-2.0
Arm fat percentage (left)	2.0	8.0	20.0	1.3	2.5	-4.5	4.5	0.5	0.1
Average weekly red wine intake	0.5	0.7	2.5	-0.3	0.3	0.7	-0.9	-0.6	-1.6
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.7	0.6	0.6	0.2	-0.3	0.8	0.7
Mood swings	0.5	0.9	2.1	-0.9	0.0	-1.5	1.4	-0.6	0.1
Loneliness, isolation	0.8	1.1	2.5	0.2	1.6	-1.3	1.3	0.5	-0.4
Long-standing illness, disability or infirmity	0.6	0.9	2.7	-0.5	0.6	-1.1	1.0	1.6	-0.1
Ever had bowel cancer screening	1.1	1.3	2.9	-1.7	1.2	-0.6	0.4	1.7	-0.2
Diabetes diagnosed by doctor	0.5	0.8	2.2	-0.5	-0.3	-1.3	1.5	0.5	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.3	-0.8	-1.1	0.3	0.1	0.4	-0.6
Friendships satisfaction	1.0	1.2	1.7	-1.3	0.7	-1.3	1.1	-1.2	0.7
Qualifications: nursing, teaching	0.3	0.5	0.9	0.4	-0.9	0.7	-0.9	-0.8	0.1
Commuting to job workplace: Walk	0.5	0.5	1.3	0.3	-1.1	0.9	-0.4	-0.6	-0.6
Eye problems/disorders: Cataract	1.2	1.4	2.5	-0.3	0.5	-1.5	1.6	1.0	1.5
Mouth/teeth dental problems: Mouth ulcers	1.8	2.9	9.3	0.3	3.1	-2.0	1.6	1.0	0.6
Medication for cholesterol	0.9	1.4	3.2	-0.9	1.8	0.9	-0.9	1.6	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	3.0	-1.2	-0.4	1.0	-0.9	-1.7	-1.7
Back pain experienced in last month	0.5	0.8	2.5	-0.2	1.6	-0.5	0.3	0.6	1.2
Mineral and other dietary supplements	0.2	0.2	0.7	-0.3	0.2	-0.5	0.9	-0.3	-0.2
Breast cancer (self-reported)	1.4	1.7	2.8	1.4	0.9	-1.6	1.7	1.3	0.4
Asthma (self-reported)	0.3	0.7	2.2	1.5	0.0	-0.1	0.2	-1.3	-0.4
Osteoporosis (self-reported)	0.7	0.8	3.0	0.8	-0.4	0.7	-0.7	-0.0	-1.7
Osteoarthritis (self-reported)	0.6	0.7	2.5	-0.0	0.9	-0.6	0.5	0.7	1.6
Medication: Aspirin	0.2	0.3	0.6	-0.5	-0.6	-0.3	0.6	-0.8	-0.5
Medication: Gliclazide	0.9	1.0	2.6	0.3	1.6	-1.4	1.1	0.3	-0.5
Illnesses of father: None of the above (group 1)	0.2	0.3	0.7	-0.8	0.8	-0.5	0.2	-0.1	0.3
Smoking status: Current	0.3	0.4	2.2	-0.1	1.5	-0.4	0.4	-0.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.6	1.3	-0.1	-0.7	1.1	0.5	0.4
Whole body water mass	4.0	22.7	52.7	2.7	-3.6	7.3	-6.8	-3.3	-2.5
Leg predicted mass (right)	2.5	13.3	29.5	2.4	-3.5	5.4	-4.8	-2.5	-1.9
Arm fat mass (left)	0.4	1.7	3.0	1.6	1.0	-1.7	1.7	-0.6	-0.8
Number of self-reported non-cancer illnesses	1.4	2.4	4.8	-1.7	1.2	-2.2	2.2	-0.7	-0.5
Average weekly champagne plus white wine intake	0.2	0.3	0.7	0.8	-0.8	0.4	-0.1	-0.4	-0.3
Miserableness	1.6	2.7	7.2	-0.5	2.0	-2.7	2.0	-0.1	-0.7
Guilty feelings	1.1	1.6	2.9	-0.8	1.6	-1.5	1.7	-1.1	0.7
Wears glasses or contact lenses	1.8	2.0	6.0	0.5	2.5	-0.9	0.5	-1.0	2.0
Ever taken oral contraceptive pill	1.1	1.2	2.1	0.3	1.1	-1.3	1.3	1.4	0.5
Hearing aid user	2.4	2.8	8.4	-0.4	-0.1	2.8	-2.9	-0.0	-0.5
Mother’s age at death	0.1	0.2	0.5	-0.7	-0.6	-0.1	0.0	0.2	0.2
Financial situation satisfaction	0.8	0.9	2.9	-1.7	-0.3	-0.6	0.6	-0.5	-1.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.8	-1.7	-0.4	-0.3	0.3	0.8	-0.3
Commuting to job workplace: Public transport	0.3	0.4	0.9	0.2	0.9	-0.7	1.0	0.3	0.4
Eye problems/disorders: Glaucoma	1.6	1.9	4.0	-0.8	2.0	-1.6	1.6	-0.2	-1.3
Medication: Blood pressure	1.9	3.6	8.3	0.6	-2.0	-2.8	2.9	-1.0	0.4
Pain type(s) experienced in last month: Hip pain	1.4	1.8	3.2	-1.4	1.8	-1.4	1.4	1.1	0.4
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.0	0.5	0.3	1.4	-1.7	-0.3	-0.5
High cholesterol (Self-reported)	0.7	1.3	2.6	-0.8	-0.9	0.6	-1.0	-1.5	-1.6
Medication: Bendroflumethiazide	1.0	1.5	4.7	0.8	-1.7	-0.5	1.0	-2.2	-0.1
Medication: Paracetamol	2.4	3.7	5.9	-1.8	2.3	-2.4	2.2	1.9	0.1
Medication: Lisinopril	1.8	2.4	4.8	-2.2	-0.6	-2.0	2.1	-0.7	-0.4
Medication: Atorvastatin	1.0	1.3	3.4	0.5	-0.4	-0.7	0.8	-1.7	-1.9
Illnesses of father: High blood pressure	1.6	2.0	3.5	0.4	-1.9	1.5	-1.3	-1.4	-1.6
Alcohol drinker status: Never	0.8	1.0	3.3	0.1	-0.4	1.5	-1.8	-0.3	-0.3
Ever smoked	0.5	0.8	2.6	-0.3	1.6	-0.9	0.6	0.2	-1.1
Basal metabolic rate	2.8	15.5	34.1	2.6	-2.8	5.8	-5.5	-3.0	-2.4
Leg fat percentage (left)	2.7	9.6	23.4	0.8	3.2	-4.8	4.7	1.0	0.5
Arm fat-free mass (left)	3.4	17.5	40.4	1.9	-3.0	6.4	-6.1	-3.0	-2.3
Number of operations (self-reported)	2.0	3.0	7.5	-1.0	2.7	-1.6	1.1	1.5	2.0
Average weekly beer plus cider intake	1.7	2.5	7.0	-0.0	0.4	-2.6	2.6	0.2	1.1
Irritability	2.0	3.3	7.4	-1.2	2.3	-2.7	2.3	0.7	0.2
Risk taking	0.4	0.6	1.2	-0.2	-0.5	1.1	-0.9	0.4	-1.0
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.6	-1.6	-0.3	1.2	-1.5	-0.6	1.1
Fractured/broken bones in last 5 years	0.3	0.4	1.0	-0.9	1.0	-0.4	0.2	-0.3	0.5
Age started oral contraceptive pill	0.2	0.3	0.5	-0.6	-0.2	-0.5	0.6	-0.7	-0.1
Diastolic blood pressure, automated reading	2.8	8.8	23.4	1.0	-1.9	-4.0	4.8	-2.1	2.0
Ever depressed for a whole week	0.1	0.2	0.4	-0.4	0.2	0.2	-0.3	0.7	0.6
Unable to work because of sickness or disability	1.5	2.0	5.2	-1.1	0.3	-0.8	0.7	2.3	2.0
Commuting to job workplace: Cycle	0.2	0.2	0.8	0.6	0.3	-0.3	0.3	0.2	0.9
Myopia	1.1	1.7	4.1	-0.7	2.0	-1.0	0.7	2.0	0.3
Vascular/heart problems diagnosed by doctor	0.9	2.3	5.7	0.1	1.8	2.0	-2.4	1.1	0.2
Cholesterol lowering medication	0.9	1.3	6.5	0.2	-1.0	0.1	-0.1	-2.5	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	4.1	-0.0	1.2	-0.6	0.7	-0.5	2.0
Pain experienced in last month	1.1	1.9	4.2	-0.6	-1.7	1.4	-1.4	-0.4	-2.0
Supplements: Calcium	1.1	1.2	3.4	1.9	0.1	1.2	-1.6	0.2	-0.1
Basal cell carcinoma (self-reported)	1.8	2.1	4.7	0.0	0.7	-2.2	2.1	1.6	-0.6
Heart attack/myocardial infarction (self-reported)	0.7	0.8	2.3	-1.0	-1.5	0.8	-0.7	-0.6	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.7	-0.0	0.2	0.0	-0.3	0.9	1.6
Heart disease (siblings)	0.6	0.7	1.4	0.3	-0.8	1.2	-1.0	0.5	-0.8
Alcohol drinker status: Previous	0.9	1.0	4.2	0.6	2.1	0.6	-0.7	-0.1	0.8
Pack years of smoking	0.8	1.2	3.5	-0.8	-0.8	0.8	-0.6	-1.9	-1.1
Impedance of whole body	6.0	30.3	70.7	-1.7	6.3	-8.4	7.4	3.0	2.4
Leg fat mass (left)	0.5	1.9	4.1	1.0	1.5	-2.0	2.0	-0.2	-0.5
Arm predicted mass (left)	3.3	16.8	39.9	1.9	-2.8	6.3	-6.0	-2.9	-2.0