Hub : Genes

ADM

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0506	0.0181	3.3e-04	0.033	0.026	0.015	0.026	0.026	9.6e-06	6.5e-05	2.1e-03	7.4e-05	8.3e-05
2	NTR	Blood	0.0444	0.0123	1.1e-10	0.039	0.036	0.042	0.037	0.040	1.4e-12	1.3e-11	1.6e-13	6.2e-12	6.2e-13
3	YFS	Blood	0.0832	0.0171	0.0e+00	0.110	0.098	0.116	0.108	0.111	4.3e-34	3.2e-30	9.4e-36	1.7e-33	2.8e-34
4	TCGA	Pheochromocytoma and Paraganglioma	0.0820	0.0540	8.2e-03	0.019	0.033	0.020	NA	0.019	5.7e-02	1.8e-02	5.3e-02	NA	5.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.2	1.9	2.5	-1.4	-1.1	-1.3	1.6
Bipolar Disorder or Schizophrenia	0.2	0.4	1.0	-0.5	-0.4	-0.4	1.0
Depressed Affect (Nagel 2018)	3.9	8.3	12.1	2.6	3.5	2.8	-2.6
Depression (Nagel 2018)	1.6	2.5	5.2	0.8	2.3	1.7	-1.0
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.5	-1.2	0.2	0.6	1.2
Neuroticism (Nagel 2018)	8.3	19.4	25.9	3.4	5.1	4.8	-4.1
Schizophrenia (2018)	0.1	0.2	0.3	0.5	0.3	0.5	0.0
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	0.3	0.8	0.5	-0.4
Worry (Nagel 2018)	6.3	13.4	18.5	2.6	4.1	4.3	-3.4
Alzheimer’s Disease (in mother)	0.4	0.5	1.7	0.5	0.2	0.1	-1.3
Alzheimer’s Disease (in father)	1.1	1.2	2.3	1.5	1.0	1.0	-0.6
Alzheimer’s Disease (including proxy)	0.5	0.7	1.8	1.3	0.3	0.2	-0.9
Crohns Disease (2017)	0.7	1.6	5.2	0.9	-0.1	-0.7	-2.3
Irritable Bowel Disease (IBD)	0.3	0.7	1.2	1.1	-0.4	-0.8	-0.9
Ulcerative Colitis (UC)	0.1	0.3	1.0	1.0	0.0	-0.0	0.2
Major Depression (MDD)	0.5	0.6	1.0	-0.9	-0.6	-0.6	1.0
Reaction Time	0.3	0.5	1.0	-1.0	0.3	0.9	-0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.8	-0.9	-0.0	0.0	1.3
Breast Cancer	5.0	12.1	19.2	-2.2	-3.4	-3.6	4.4
Ovarian Cancer	0.1	0.1	0.3	0.3	0.2	0.1	-0.6
Prostate Cancer	4.3	6.0	8.5	1.9	2.8	2.9	-2.0
Age at First Birth	0.3	0.4	1.6	-1.3	0.1	-0.0	-0.2
Bipolar Disorder (2011)	1.5	1.4	1.7	-1.3	-0.9	-1.2	1.3
Body Mass Index (BMI) (2010)	0.1	0.2	0.6	-0.2	0.2	-0.1	-0.8
Coronary Artery Disease (CAD)	0.3	0.4	0.6	-0.7	0.8	0.7	0.0
Crohns Disease (2012)	0.7	1.1	3.1	-0.2	-0.7	-1.8	-1.0
Mean Putamen Volume	0.3	0.3	0.8	-0.9	-0.5	-0.2	0.6
Fasting Glucose	0.4	0.5	1.2	-0.2	0.5	0.7	-1.1
HbA1C	3.6	4.0	6.4	2.5	1.6	1.5	-2.2
HDL Cholesterol	3.0	4.9	7.8	2.8	2.5	2.2	-1.1
LDL Cholesterol	1.1	1.8	3.6	-0.3	-1.4	-1.9	1.2
Lupus	0.6	1.0	2.0	-0.8	-1.4	-0.5	1.0
Neuroticism (2016)	12.8	18.5	29.2	2.1	5.4	5.0	-3.9
Primary Biliary Cirrhosis	0.2	0.3	0.6	-0.1	0.2	-0.8	-0.6
Rheumatoid Arthritis	3.7	5.1	8.8	-1.4	-2.4	-3.0	2.0
Schizophrenia (2014)	0.1	0.2	0.8	-0.1	-0.2	-0.2	0.9
Triglycerides	1.7	2.7	4.8	-2.2	-1.6	-1.7	0.8
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.9	0.6	0.6	0.2	-1.0
Ulcerative Colitis	0.5	0.7	1.5	0.4	-1.2	-0.6	0.9
Blood Eosinophil Count	0.5	3.7	5.9	-0.5	-2.4	-2.4	1.7
Blood Platelet Count	0.1	1.1	4.2	0.1	0.1	-2.0	-0.3
Blood Red Count	9.3	89.4	166.4	2.5	-10.6	-12.9	8.5
Blood White Count	1.5	11.2	18.6	-4.3	-2.7	-2.6	3.5
Heel T-Score	0.6	4.5	8.9	1.6	1.7	3.0	-1.9
BMI	0.1	0.5	2.0	1.4	-0.1	0.2	-0.3
Height	1.8	35.1	54.3	-1.9	-7.4	-7.3	5.4
Waist Hip Ratio (WHR)	12.6	56.8	78.9	7.7	8.9	6.8	-6.5
Systolic Blood Pressure	5.4	26.8	69.6	-1.1	4.9	8.3	-3.5
Smoking Status	0.1	0.1	0.3	0.3	0.5	-0.3	0.3
Allergy or Eczema	1.2	3.0	5.6	0.9	2.2	2.4	-0.9
Cardiovascular Disease	1.5	5.0	13.1	-0.6	2.3	3.6	-1.1
Hypothyroidism (self reported)	0.7	1.7	3.0	-1.7	-0.7	-1.2	1.3
Respiratory disease	0.7	1.5	3.0	1.7	0.8	1.4	-0.6
Type 2 Diabetes (T2D) (2018)	1.2	2.2	3.1	1.8	1.6	0.8	-1.5
Lung FEV1/FVC ratio	4.2	21.4	30.6	2.2	5.5	5.5	-4.4
Lung FVC	0.7	3.8	6.1	-2.3	-1.1	-1.7	2.5
Neuroticism	7.3	17.5	24.5	2.8	5.0	4.9	-3.8
Chronotype (morning person)	0.6	1.4	2.3	-1.3	-1.1	-1.5	0.6
Hair Pigment	1.1	30.9	54.5	-2.1	-6.4	-7.4	4.9
Tanning	0.4	4.5	10.6	0.5	2.6	3.2	-0.6
Hand grip strength (left)	2.3	5.9	9.0	-1.3	-3.0	-2.8	2.2
Number of treatments/medications taken	0.3	0.6	1.1	0.7	0.9	1.0	0.3
Average weekly spirits intake	0.5	0.6	1.0	0.2	0.9	1.0	-0.9
Sensitivity / hurt feelings	3.4	5.8	9.1	1.5	3.0	2.8	-2.0
Frequency of depressed mood in last 2 weeks	0.9	1.2	3.0	0.6	1.7	1.1	-0.8
Hearing difficulty/problems: Yes	1.5	2.3	3.5	0.3	-1.9	-1.7	1.6
Relative age of first facial hair	3.7	7.6	8.4	-2.8	-2.9	-2.5	2.8
Other serious medical condition/disability diagnosed by doctor	5.3	6.8	8.8	3.0	2.5	2.1	-2.7
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.2	1.8	-0.8	-1.3	0.8
Ever had hysterectomy (womb removed)	5.8	6.5	9.7	2.5	3.1	2.4	-2.1
Systolic blood pressure, automated reading	6.9	20.0	48.6	-0.5	4.2	7.0	-3.6
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.3	0.7	0.4	-0.1	-1.1
Angina	0.4	0.6	1.5	-1.2	0.1	0.6	-0.7
Medication for hormone replacement therapy	1.1	1.3	2.4	-0.3	-1.4	-1.5	0.8
Vitamin and mineral supplements	1.4	1.9	3.1	0.8	1.5	1.8	-1.3
Supplements: Zinc	1.5	1.7	2.1	-1.5	-1.3	-1.3	1.1
Medication: Co-codamol	0.1	0.1	0.4	-0.1	0.4	0.6	-0.1
Medication: Metformin	0.2	0.3	1.2	1.1	0.2	-0.2	0.1
Diabetes (father)	1.2	1.4	2.8	0.4	1.7	1.2	-1.1
Diabetes (mother)	1.0	1.3	2.3	0.1	1.3	1.5	-1.1
Severe depression (siblings)	0.4	0.4	1.1	-0.3	0.5	1.1	0.3
Pack years adult smoking proportion	0.4	0.6	1.2	-1.0	-0.3	-0.5	1.1
Impedance of leg (right)	6.0	29.2	47.2	4.7	6.9	6.1	-3.3
Leg fat-free mass (left)	2.5	13.1	23.6	-1.9	-4.9	-4.4	2.4
Trunk fat percentage	5.9	23.7	34.7	4.2	5.6	5.9	-3.3
Hand grip strength (right)	1.5	4.1	6.9	-1.0	-2.4	-2.6	1.7
Townsend deprivation index at recruitment	3.2	4.5	6.0	1.3	2.4	2.1	-2.4
Current tobacco smoking	0.3	0.4	1.5	0.4	1.2	0.1	-0.0
Average weekly fortified wine intake	0.1	0.1	0.2	-0.0	-0.4	0.2	0.2
Maternal smoking around birth	1.5	2.1	3.7	1.5	1.9	1.5	-0.7
Fed-up feelings	1.5	2.7	4.7	1.2	2.2	1.8	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	2.8	0.9	1.7	1.1	-1.0
Relative age voice broke	3.4	5.2	8.7	-1.2	-2.4	-2.2	3.0
Taking other prescription medications	2.0	3.1	5.3	1.4	2.1	2.3	-0.8
Age when periods started (menarche)	0.5	1.1	3.5	-1.9	0.4	0.8	0.5
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	4.1	2.0	1.5	0.8	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.0	1.7	0.4	0.9	-1.1
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	3.6	-1.9	-0.2	-0.1	1.8
Qualifications: CSEs or equivalent	0.5	0.6	2.0	0.2	0.7	0.0	-1.4
Serious illness, injury or assault to yourself	1.8	2.1	3.4	1.7	1.0	1.2	-1.8
High blood pressure	2.8	7.8	17.6	0.6	3.1	4.2	-1.8
Hayfever, allergic rhinitis or eczema	0.8	1.7	3.6	0.5	1.7	1.9	-0.1
Multivitamins +/- minerals	0.4	0.5	1.1	0.4	-0.7	-1.0	0.5
Stomach or abdominal pain in last month	0.2	0.3	1.0	1.0	-0.0	-0.1	-0.3
Supplements: Glucosamine	0.9	1.2	2.4	1.5	-0.5	-1.1	0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.3	-0.3	1.1	1.0	0.1
Medication: Atenolol	0.4	0.5	1.1	-0.0	0.9	1.0	-0.2
Medication: Levothyroxine sodium	0.1	0.2	0.5	-0.7	0.1	-0.3	-0.2
Sitting height	2.6	18.7	25.8	-2.3	-5.1	-4.8	4.6
Chronic bronchitis/emphysema (father)	2.1	2.5	6.5	2.5	0.8	0.7	-1.5
High blood pressure (mother)	1.1	1.5	4.4	-2.1	0.6	1.1	0.4
Body mass index (BMI)	0.1	0.5	1.2	1.1	0.4	0.7	-0.3
Impedance of leg (left)	5.7	27.8	47.3	4.5	6.9	5.9	-3.1
Leg predicted mass (left)	2.4	12.9	23.4	-1.8	-4.8	-4.4	2.4
Trunk fat mass	1.8	7.6	10.4	3.0	2.9	3.2	-1.7
Waist circumference	0.4	1.6	4.3	2.1	1.1	0.9	-0.3
Number of incorrect matches in round	0.2	0.3	0.7	-0.8	-0.5	-0.1	0.6
Past tobacco smoking	0.3	0.5	1.9	-1.4	-0.5	-0.0	-0.1
Alcohol usually taken with meals	1.4	2.2	4.0	-0.7	-2.0	-1.3	1.6
Nervous feelings	6.0	11.3	18.1	1.6	4.1	4.2	-2.8
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	3.4	1.9	1.4	0.6	-0.9
Hearing difficulty/problems with background noise	1.0	1.6	6.0	2.5	-0.2	-0.1	0.4
Hair/balding pattern: Pattern 2	1.0	1.3	3.4	0.0	1.3	1.8	-0.0
Had menopause	0.3	0.3	0.8	0.9	0.1	-0.3	0.6
Had other major operations	0.9	1.1	2.1	1.4	0.9	0.8	-1.0
Forced vital capacity (FVC)	0.5	1.9	2.2	-1.4	-1.0	-1.5	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.1	1.1	0.4	0.6	-1.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.3	0.5	-0.1	-0.3	-0.6
Qualifications: None of the above	0.7	1.5	2.3	-0.1	-1.2	-1.5	1.5
Financial difficulties in last 2 years	0.3	0.5	0.9	0.1	0.7	0.7	-0.9
Mouth/teeth dental problems	2.4	3.7	9.9	-3.1	-1.8	-1.0	0.9
Heart attack	0.7	0.9	2.7	-0.6	-0.8	-1.6	0.2
Allergy	0.5	1.2	2.1	-1.2	-1.2	-1.4	0.1
Pain all over the body in last month	0.7	0.7	1.1	-0.1	-0.9	-0.9	1.0
Diabetes (self-reported)	1.8	2.7	5.4	2.3	1.8	1.1	-1.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	-0.5	0.2	0.8	-0.3
Medication: Ramipril	0.2	0.3	0.6	-0.7	-0.3	-0.6	0.3
Medication: Simvastatin	0.1	0.1	0.5	-0.3	-0.1	0.1	0.7
Fluid intelligence score	0.5	0.9	3.2	-0.6	0.2	0.4	1.8
Illnesses of siblings	0.3	0.4	0.7	0.5	-0.8	-0.7	-0.3
Neuroticism score	6.9	14.5	23.3	2.4	4.8	4.5	-2.9
Weight	0.4	1.7	3.1	0.6	-1.8	-1.5	1.2
Impedance of arm (right)	8.6	40.2	64.5	3.2	8.0	8.0	-4.7
Arm fat percentage (right)	3.9	15.4	24.2	3.1	4.4	4.9	-2.8
Trunk fat-free mass	7.3	41.8	68.2	-3.2	-8.3	-7.9	5.1
Hip circumference	2.1	9.2	13.7	-1.9	-3.7	-3.0	3.2
Time employed in main current job	0.3	0.3	1.0	0.6	0.1	-0.1	-1.0
Alcohol intake versus 10 years previously	0.1	0.2	0.4	0.4	-0.5	-0.7	-0.0
Father’s age at death	1.1	1.4	2.9	-0.8	-1.7	-1.2	0.9
Worrier / anxious feelings	3.5	6.6	10.9	0.8	3.1	3.3	-2.3
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.1	6.5	2.5	2.4	1.3	-1.6
Falls in the last year	2.7	3.7	6.2	1.1	2.5	2.1	-1.8
Hair/balding pattern: Pattern 3	1.8	2.7	3.4	1.4	1.8	1.5	-1.7
Number of live births	0.3	0.4	1.2	0.1	1.1	0.6	-0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.5	-0.2	1.2	0.8	-0.6
Pulse rate	2.7	4.5	8.3	1.6	2.0	1.8	-2.9
Happiness	3.2	3.9	7.1	0.8	2.0	2.7	-1.9
Noisy workplace	0.3	0.4	1.2	-0.2	-0.5	-1.1	-0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.1	0.4	-1.0	-1.0	0.3
Serious illness, injury or assault of a close relative in last 2 years	2.5	2.9	3.9	1.8	1.6	1.3	-2.0
Mouth/teeth dental problems: Dentures	0.9	1.4	4.9	2.2	0.5	-0.4	-0.7
Asthma	0.1	0.3	0.6	0.4	0.1	0.8	0.5
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	4.3	-0.0	-1.0	-2.1	-0.2
Medication: Cholesterol lowering	0.3	0.5	1.1	-0.3	-0.6	-1.0	0.8
Depression (self-reported)	0.2	0.3	0.8	0.3	-0.4	0.0	0.9
Medication: Lansoprazole	1.5	1.7	4.7	2.2	1.0	1.1	-0.3
Prospective memory result	0.8	0.9	1.1	-1.0	-1.0	-0.8	1.0
Lung cancer (father)	2.5	3.0	4.7	0.8	2.2	1.9	-1.7
Illnesses of mother	0.1	0.2	0.3	0.4	-0.5	-0.5	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.6	-1.3	0.4	-0.2	0.5
Pulse wave Arterial Stiffness index	0.8	1.0	1.9	0.5	1.1	0.6	-1.4
Impedance of arm (left)	8.0	37.1	61.6	3.0	7.7	7.9	-4.4
Arm fat mass (right)	0.6	2.6	3.6	1.9	1.6	1.9	-0.9
Trunk predicted mass	7.3	41.6	67.6	-3.1	-8.2	-8.0	5.1
Standing height	1.7	16.7	27.0	-1.3	-5.1	-5.2	3.5
Length of working week for main job	0.1	0.1	0.2	0.4	0.2	0.1	-0.5
Exposure to tobacco smoke at home	1.0	1.1	2.3	-0.2	-1.5	-1.5	0.3
Breastfed as a baby	0.5	0.6	1.2	-1.1	0.5	0.8	-0.6
Tense / ‘highly strung’	3.3	5.5	7.3	2.6	2.7	2.5	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.5	5.3	2.3	1.7	1.8	-1.7
Hair/balding pattern: Pattern 4	0.8	2.0	3.2	-0.3	1.3	1.8	-1.7
Birth weight of first child	0.4	0.7	1.4	0.1	-1.1	-1.2	-0.1
Peak expiratory flow (PEF)	1.5	3.4	6.5	0.2	2.5	2.1	-1.6
Pulse wave reflection index	2.5	3.0	4.8	1.7	2.2	1.1	-1.8
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.6	0.3	1.0	1.6	-0.7
Loud music exposure frequency	0.0	0.0	0.1	0.3	0.1	0.2	0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.9	-0.4	0.9	0.9	-0.7
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	2.4	1.6	0.6	0.6	-0.9
Blood clot in the leg (DVT)	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.2
Medication: Paracetamol	1.1	1.8	3.3	1.2	1.8	1.3	-0.9
Headache pain in last month	0.5	0.9	2.0	1.1	-0.1	-1.4	0.5
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.2	0.2	-0.1	0.0	0.4
Glaucoma (self-reported)	0.7	0.9	1.3	0.6	1.0	1.1	-0.8
Gout (self-reported)	0.3	0.4	0.9	-0.3	0.5	0.9	-0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.7	-0.9	0.2	-0.5	0.3
Medication: Amlodipine	0.5	0.6	1.7	0.3	0.9	1.3	-0.0
Medication: Ventolin 100micrograms inhaler	1.7	2.2	5.1	0.8	1.7	2.2	-0.3
Birth weight	5.2	11.3	18.1	-2.3	-4.3	-3.8	2.8
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.0	0.7	0.7	1.4	-0.6
High blood pressure (siblings)	0.9	1.3	2.4	-0.2	1.5	1.6	-0.8
Forced vital capacity (FVC), Best measure	1.2	4.4	6.2	-2.5	-1.7	-2.0	2.1
Body fat percentage	5.9	23.4	33.3	4.2	5.5	5.8	-3.4
Leg fat percentage (right)	5.3	19.4	26.1	4.3	5.0	5.1	-2.8
Arm fat-free mass (right)	5.3	27.1	44.0	-2.0	-6.6	-6.6	4.1
Exposure to tobacco smoke outside home	1.0	1.4	3.3	1.8	0.8	1.2	-0.1
Comparative body size at age 10	0.3	0.9	2.0	-0.9	-1.0	-1.4	0.1
Number of full brothers	1.4	1.8	3.4	-1.8	-0.8	-0.5	1.7
Worry too long after embarrassment	3.5	5.9	10.7	0.8	2.8	3.3	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.8	0.9	0.4	0.6	-0.2
Wheeze or whistling in the chest in last year	0.2	0.4	1.5	-0.0	0.4	1.2	0.2
Number of children fathered	0.2	0.3	1.0	1.0	0.0	0.2	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.6	1.1	0.5	1.3	0.2
Age at first live birth	3.2	5.7	7.8	-2.8	-2.7	-1.8	2.0
Pulse wave peak to peak time	1.3	1.6	3.0	-0.5	-1.4	-1.0	1.7
Health satisfaction	3.1	4.0	6.0	1.5	2.1	2.5	-1.9
Shortness of breath walking on level ground	3.1	3.7	6.0	0.8	2.3	2.5	-1.7
Qualifications: College or University degree	0.2	0.5	1.7	0.1	-0.5	0.3	1.3
Eye problems/disorders: None of the above	4.3	5.0	5.5	-2.3	-2.3	-2.3	2.0
Mouth/teeth dental problems: Loose teeth	1.8	2.2	3.3	1.5	1.8	1.7	-0.6
Emphysema/chronic bronchitis	0.5	0.5	0.8	-0.3	-0.8	-0.9	0.8
Medication for pain relief, constipation, heartburn	0.3	0.5	1.2	0.3	0.5	1.1	-0.5
Neck or shoulder pain in last month	0.2	0.3	0.6	0.7	0.5	0.8	0.0
Medication: Blood pressure	0.1	0.2	0.7	-0.1	-0.1	-0.0	-0.9
Angina (self-reported)	0.6	0.8	1.9	-1.4	0.3	0.8	-0.6
Migraine (self-reported)	0.5	0.6	1.0	0.5	1.0	-0.3	-1.0
Medication: Ibuprofen	1.4	1.7	4.5	-0.6	-1.3	-2.1	0.3
Medication: Allopurinol	0.5	0.7	2.1	0.1	0.9	1.4	-0.3
Medication: Omeprazole	0.8	1.0	2.8	1.7	0.9	0.4	0.1
Medication: Seretide 50 evohaler	0.0	0.1	0.1	0.1	-0.4	0.2	0.1
Mean time to correctly identify matches	0.2	0.3	0.7	-0.1	0.1	0.7	-0.8
Heart disease (mother)	3.2	3.9	6.1	1.1	2.5	2.3	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.6	0.6	1.3	1.6	-0.9
Whole body fat mass	1.4	5.8	7.8	2.7	2.5	2.8	-1.4
Leg fat mass (right)	1.2	4.7	7.6	2.8	2.1	2.3	-1.2
Arm predicted mass (right)	5.1	26.1	42.4	-1.9	-6.5	-6.5	4.0
Pulse rate, automated reading	4.6	15.0	29.4	2.7	3.8	3.1	-5.4
Alcohol intake frequency.	0.8	1.8	4.6	-0.1	-1.6	-2.1	0.3
Comparative height size at age 10	0.4	2.0	3.8	1.4	-1.4	-1.9	-0.5
Number of full sisters	0.2	0.2	0.4	0.1	-0.4	-0.6	0.6
Suffer from ‘nerves’	3.8	5.9	7.1	2.2	2.7	2.4	-2.5
Overall health rating	2.5	5.5	8.9	2.4	2.2	1.5	-3.0
Chest pain or discomfort	1.7	2.5	4.5	1.5	1.8	2.1	-0.4
Had major operations	1.3	1.5	3.0	-0.0	1.3	1.7	-1.2
Age at last live birth	1.6	2.3	6.0	-2.4	-0.9	-0.5	1.5
Family relationship satisfaction	0.4	0.5	1.3	0.5	0.6	1.1	-0.5
Leg pain on walking	0.7	0.8	2.3	-1.0	-0.4	-0.1	1.5
Qualifications: NVQ or HND or HNC or equivalent	2.8	3.4	5.2	2.1	1.6	1.2	-2.3
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	0.8	0.2	-0.1	0.3
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	4.5	-2.1	-0.3	-0.1	1.3
Medication: Aspirin	0.3	0.4	1.1	-1.1	0.0	0.5	0.2
Supplements: Vitamin C	0.3	0.4	0.7	-0.9	-0.4	-0.6	0.5
Knee pain experienced in last month	1.0	1.5	3.3	1.0	1.3	1.8	-0.2
Hypertension (Self-reported)	3.1	8.5	18.5	0.7	3.3	4.3	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.7	1.6	0.2	0.4	-0.2
Illnesses of father: Heart disease	0.7	1.0	2.1	1.5	-0.1	-0.7	-1.2
Illnesses of siblings: Diabetes	3.9	4.7	6.1	2.0	2.5	2.1	-2.1
Smoking status: Previous	0.0	0.1	0.3	0.5	-0.0	0.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	5.3	0.6	-2.0	-2.3	0.4
Whole body fat-free mass	5.5	31.2	52.1	-2.8	-7.2	-6.9	4.2
Leg fat-free mass (right)	3.0	16.1	27.9	-2.4	-5.3	-4.9	2.7
Arm fat percentage (left)	3.8	15.0	24.9	2.9	4.4	5.0	-2.7
Average weekly red wine intake	0.8	1.2	3.0	0.6	-0.7	-1.0	1.7
Handedness (chirality/laterality): Left-handed	2.0	2.4	7.3	2.7	-0.7	-0.7	-1.1
Mood swings	1.3	2.4	3.7	1.0	1.9	1.6	-1.5
Loneliness, isolation	0.8	1.0	1.7	0.5	1.1	0.9	-1.3
Long-standing illness, disability or infirmity	1.3	2.0	6.6	2.6	0.6	0.2	-1.1
Ever had bowel cancer screening	0.2	0.3	0.8	0.5	0.0	0.2	-0.9
Diabetes diagnosed by doctor	1.1	1.8	3.8	1.9	1.4	0.7	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.4	-0.7	-0.4	0.1	0.1
Friendships satisfaction	0.9	1.2	3.2	0.2	1.1	1.8	-0.5
Qualifications: nursing, teaching	0.5	0.7	1.2	-0.7	-1.0	-0.3	1.1
Commuting to job workplace: Walk	0.3	0.3	1.1	-1.0	-0.1	0.1	0.1
Eye problems/disorders: Cataract	3.2	3.7	6.9	1.4	1.7	1.8	-2.6
Mouth/teeth dental problems: Mouth ulcers	2.4	3.9	10.8	3.3	1.6	1.1	-0.9
Medication for cholesterol	0.9	1.4	3.5	0.1	-1.4	-1.9	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	4.0	-1.1	-0.9	-0.7	2.0
Back pain experienced in last month	0.8	1.2	3.7	1.9	0.9	-0.2	0.4
Mineral and other dietary supplements	0.4	0.6	1.3	0.2	0.9	1.1	-0.1
Breast cancer (self-reported)	1.4	1.7	3.6	-0.3	1.1	1.4	-1.9
Asthma (self-reported)	0.1	0.2	0.5	0.3	0.0	0.7	0.6
Osteoporosis (self-reported)	1.0	1.3	2.7	0.4	-1.1	-1.7	1.0
Osteoarthritis (self-reported)	1.0	1.3	2.6	1.6	1.1	1.0	-0.6
Medication: Aspirin	0.3	0.4	0.9	-1.0	0.2	0.8	0.1
Medication: Gliclazide	1.0	1.2	2.1	1.4	1.1	0.6	-1.0
Illnesses of father: None of the above (group 1)	0.2	0.3	0.7	-0.8	0.3	0.5	-0.1
Smoking status: Current	0.3	0.4	1.3	0.4	1.2	0.0	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.3	-0.3	1.1	0.4	-0.0
Whole body water mass	5.5	31.5	52.9	-2.7	-7.3	-7.0	4.1
Leg predicted mass (right)	2.9	15.3	26.5	-2.3	-5.2	-4.8	2.6
Arm fat mass (left)	0.7	2.7	3.8	1.8	1.7	2.0	-0.9
Number of self-reported non-cancer illnesses	1.6	2.7	4.5	1.4	1.9	2.1	-0.9
Average weekly champagne plus white wine intake	0.4	0.5	0.8	-0.9	-0.3	0.7	0.7
Miserableness	2.7	4.7	7.5	1.6	2.7	2.4	-1.7
Guilty feelings	1.7	2.6	4.2	1.7	2.1	1.5	-1.1
Wears glasses or contact lenses	1.6	1.8	3.8	1.9	1.3	1.4	0.1
Ever taken oral contraceptive pill	1.1	1.2	1.6	0.7	1.1	1.2	-1.2
Hearing aid user	3.7	4.2	7.7	-0.1	-2.8	-2.7	1.4
Mother’s age at death	0.2	0.3	0.6	-0.8	0.2	0.4	-0.7
Financial situation satisfaction	0.1	0.2	0.3	-0.3	0.3	0.5	-0.5
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	-0.5	0.4	0.1	0.3
Commuting to job workplace: Public transport	0.2	0.2	0.4	0.1	0.6	0.3	-0.6
Eye problems/disorders: Glaucoma	1.5	1.8	3.6	0.3	1.9	1.9	-0.4
Medication: Blood pressure	4.6	8.7	18.4	1.3	3.6	4.3	-1.3
Pain type(s) experienced in last month: Hip pain	1.3	1.7	3.1	1.2	1.8	1.3	-0.6
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.2	-0.5	-1.5	-1.5	0.9
High cholesterol (Self-reported)	0.6	1.0	1.3	-1.1	-0.9	-0.9	1.0
Medication: Bendroflumethiazide	1.2	1.8	5.2	-0.1	1.4	2.3	-0.0
Medication: Paracetamol	1.5	2.3	4.4	1.2	2.1	1.3	-1.2
Medication: Lisinopril	2.6	3.3	7.2	0.8	2.2	2.7	-0.9
Medication: Atorvastatin	0.5	0.6	1.0	-1.0	0.6	0.9	0.2
Illnesses of father: High blood pressure	2.1	2.6	4.8	-1.4	-1.6	-1.1	2.2
Alcohol drinker status: Never	1.4	1.7	3.0	-0.4	-1.7	-1.6	0.9
Ever smoked	0.3	0.5	1.1	1.0	0.8	0.3	-0.0
Basal metabolic rate	3.6	20.0	34.1	-2.0	-5.8	-5.5	3.4
Leg fat percentage (left)	4.7	16.9	22.8	4.0	4.8	4.7	-2.5
Arm fat-free mass (left)	4.9	25.1	41.2	-1.7	-6.4	-6.4	3.9
Number of operations (self-reported)	1.2	1.8	3.5	1.9	0.9	1.0	-1.3
Average weekly beer plus cider intake	3.8	5.5	10.8	0.8	2.6	3.3	-2.0
Irritability	3.5	6.0	9.1	1.9	2.7	3.0	-1.9
Risk taking	0.8	1.2	2.0	-1.1	-0.3	-1.2	1.4
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.7	0.4	-1.3	-1.0	0.4
Fractured/broken bones in last 5 years	0.2	0.2	0.6	0.0	0.2	0.7	0.4
Age started oral contraceptive pill	0.3	0.4	0.9	-0.0	0.8	0.9	-0.2
Diastolic blood pressure, automated reading	7.1	22.0	50.7	-0.4	4.5	7.1	-4.1
Ever depressed for a whole week	0.2	0.2	0.4	0.3	-0.6	-0.5	-0.3
Unable to work because of sickness or disability	2.3	3.0	7.5	2.7	1.5	0.5	-1.5
Commuting to job workplace: Cycle	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.2
Myopia	0.7	1.0	2.8	1.1	0.1	-0.2	-1.7
Vascular/heart problems diagnosed by doctor	1.8	4.9	11.4	0.0	-2.4	-3.4	1.5
Cholesterol lowering medication	0.5	0.7	1.8	-1.4	-0.2	0.6	0.7
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	5.6	2.4	1.2	1.0	-0.2
Pain experienced in last month	1.8	2.9	6.7	-2.6	-1.7	-1.1	1.0
Supplements: Calcium	2.7	2.9	5.1	-1.2	-1.9	-2.2	1.2
Basal cell carcinoma (self-reported)	2.2	2.6	3.6	0.6	1.9	1.7	-1.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.5	-0.4	-0.3	-1.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	0.4	0.0	0.1	-0.5
Heart disease (siblings)	0.6	0.7	1.3	-0.4	-1.1	-1.0	0.4
Alcohol drinker status: Previous	0.2	0.2	0.3	0.2	-0.5	-0.5	0.6
Pack years of smoking	0.4	0.6	1.1	-0.9	-0.3	-0.5	1.0
Impedance of whole body	8.7	44.2	71.5	4.3	8.5	8.0	-4.7
Leg fat mass (left)	1.0	3.9	7.0	2.6	1.9	2.0	-1.1
Arm predicted mass (left)	4.7	24.0	39.6	-1.6	-6.3	-6.3	3.8