Hub : Genes

ADM

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0506 0.0181 3.3e-04 0.033 0.026 0.015 0.026 0.026 9.6e-06 6.5e-05 2.1e-03 7.4e-05 8.3e-05
2 NTR Blood 0.0444 0.0123 1.1e-10 0.039 0.036 0.042 0.037 0.040 1.4e-12 1.3e-11 1.6e-13 6.2e-12 6.2e-13
3 YFS Blood 0.0832 0.0171 0.0e+00 0.110 0.098 0.116 0.108 0.111 4.3e-34 3.2e-30 9.4e-36 1.7e-33 2.8e-34
4 TCGA Pheochromocytoma and Paraganglioma 0.0820 0.0540 8.2e-03 0.019 0.033 0.020 NA 0.019 5.7e-02 1.8e-02 5.3e-02 NA 5.6e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.2 1.9 2.5 -1.4 -1.1 -1.3 1.6
Bipolar Disorder or Schizophrenia 0.2 0.4 1.0 -0.5 -0.4 -0.4 1.0
Depressed Affect (Nagel 2018) 3.9 8.3 12.1 2.6 3.5 2.8 -2.6
Depression (Nagel 2018) 1.6 2.5 5.2 0.8 2.3 1.7 -1.0
Intelligence (Savage-Jansen 2018) 0.3 0.8 1.5 -1.2 0.2 0.6 1.2
Neuroticism (Nagel 2018) 8.3 19.4 25.9 3.4 5.1 4.8 -4.1
Schizophrenia (2018) 0.1 0.2 0.3 0.5 0.3 0.5 0.0
Schizophrenia vs Biploar Disorder 0.2 0.3 0.6 0.3 0.8 0.5 -0.4
Worry (Nagel 2018) 6.3 13.4 18.5 2.6 4.1 4.3 -3.4
Alzheimer’s Disease (in mother) 0.4 0.5 1.7 0.5 0.2 0.1 -1.3
Alzheimer’s Disease (in father) 1.1 1.2 2.3 1.5 1.0 1.0 -0.6
Alzheimer’s Disease (including proxy) 0.5 0.7 1.8 1.3 0.3 0.2 -0.9
Crohns Disease (2017) 0.7 1.6 5.2 0.9 -0.1 -0.7 -2.3
Irritable Bowel Disease (IBD) 0.3 0.7 1.2 1.1 -0.4 -0.8 -0.9
Ulcerative Colitis (UC) 0.1 0.3 1.0 1.0 0.0 -0.0 0.2
Major Depression (MDD) 0.5 0.6 1.0 -0.9 -0.6 -0.6 1.0
Reaction Time 0.3 0.5 1.0 -1.0 0.3 0.9 -0.1
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.8 -0.9 -0.0 0.0 1.3
Breast Cancer 5.0 12.1 19.2 -2.2 -3.4 -3.6 4.4
Ovarian Cancer 0.1 0.1 0.3 0.3 0.2 0.1 -0.6
Prostate Cancer 4.3 6.0 8.5 1.9 2.8 2.9 -2.0
Age at First Birth 0.3 0.4 1.6 -1.3 0.1 -0.0 -0.2
Bipolar Disorder (2011) 1.5 1.4 1.7 -1.3 -0.9 -1.2 1.3
Body Mass Index (BMI) (2010) 0.1 0.2 0.6 -0.2 0.2 -0.1 -0.8
Coronary Artery Disease (CAD) 0.3 0.4 0.6 -0.7 0.8 0.7 0.0
Crohns Disease (2012) 0.7 1.1 3.1 -0.2 -0.7 -1.8 -1.0
Mean Putamen Volume 0.3 0.3 0.8 -0.9 -0.5 -0.2 0.6
Fasting Glucose 0.4 0.5 1.2 -0.2 0.5 0.7 -1.1
HbA1C 3.6 4.0 6.4 2.5 1.6 1.5 -2.2
HDL Cholesterol 3.0 4.9 7.8 2.8 2.5 2.2 -1.1
LDL Cholesterol 1.1 1.8 3.6 -0.3 -1.4 -1.9 1.2
Lupus 0.6 1.0 2.0 -0.8 -1.4 -0.5 1.0
Neuroticism (2016) 12.8 18.5 29.2 2.1 5.4 5.0 -3.9
Primary Biliary Cirrhosis 0.2 0.3 0.6 -0.1 0.2 -0.8 -0.6
Rheumatoid Arthritis 3.7 5.1 8.8 -1.4 -2.4 -3.0 2.0
Schizophrenia (2014) 0.1 0.2 0.8 -0.1 -0.2 -0.2 0.9
Triglycerides 1.7 2.7 4.8 -2.2 -1.6 -1.7 0.8
Type 2 Diabetes (T2D) (2012) 0.4 0.4 0.9 0.6 0.6 0.2 -1.0
Ulcerative Colitis 0.5 0.7 1.5 0.4 -1.2 -0.6 0.9
Blood Eosinophil Count 0.5 3.7 5.9 -0.5 -2.4 -2.4 1.7
Blood Platelet Count 0.1 1.1 4.2 0.1 0.1 -2.0 -0.3
Blood Red Count 9.3 89.4 166.4 2.5 -10.6 -12.9 8.5
Blood White Count 1.5 11.2 18.6 -4.3 -2.7 -2.6 3.5
Heel T-Score 0.6 4.5 8.9 1.6 1.7 3.0 -1.9
BMI 0.1 0.5 2.0 1.4 -0.1 0.2 -0.3
Height 1.8 35.1 54.3 -1.9 -7.4 -7.3 5.4
Waist Hip Ratio (WHR) 12.6 56.8 78.9 7.7 8.9 6.8 -6.5
Systolic Blood Pressure 5.4 26.8 69.6 -1.1 4.9 8.3 -3.5
Smoking Status 0.1 0.1 0.3 0.3 0.5 -0.3 0.3
Allergy or Eczema 1.2 3.0 5.6 0.9 2.2 2.4 -0.9
Cardiovascular Disease 1.5 5.0 13.1 -0.6 2.3 3.6 -1.1
Hypothyroidism (self reported) 0.7 1.7 3.0 -1.7 -0.7 -1.2 1.3
Respiratory disease 0.7 1.5 3.0 1.7 0.8 1.4 -0.6
Type 2 Diabetes (T2D) (2018) 1.2 2.2 3.1 1.8 1.6 0.8 -1.5
Lung FEV1/FVC ratio 4.2 21.4 30.6 2.2 5.5 5.5 -4.4
Lung FVC 0.7 3.8 6.1 -2.3 -1.1 -1.7 2.5
Neuroticism 7.3 17.5 24.5 2.8 5.0 4.9 -3.8
Chronotype (morning person) 0.6 1.4 2.3 -1.3 -1.1 -1.5 0.6
Hair Pigment 1.1 30.9 54.5 -2.1 -6.4 -7.4 4.9
Tanning 0.4 4.5 10.6 0.5 2.6 3.2 -0.6
Hand grip strength (left) 2.3 5.9 9.0 -1.3 -3.0 -2.8 2.2
Number of treatments/medications taken 0.3 0.6 1.1 0.7 0.9 1.0 0.3
Average weekly spirits intake 0.5 0.6 1.0 0.2 0.9 1.0 -0.9
Sensitivity / hurt feelings 3.4 5.8 9.1 1.5 3.0 2.8 -2.0
Frequency of depressed mood in last 2 weeks 0.9 1.2 3.0 0.6 1.7 1.1 -0.8
Hearing difficulty/problems: Yes 1.5 2.3 3.5 0.3 -1.9 -1.7 1.6
Relative age of first facial hair 3.7 7.6 8.4 -2.8 -2.9 -2.5 2.8
Other serious medical condition/disability diagnosed by doctor 5.3 6.8 8.8 3.0 2.5 2.1 -2.7
Ever used hormone-replacement therapy (HRT) 1.2 1.5 3.2 1.8 -0.8 -1.3 0.8
Ever had hysterectomy (womb removed) 5.8 6.5 9.7 2.5 3.1 2.4 -2.1
Systolic blood pressure, automated reading 6.9 20.0 48.6 -0.5 4.2 7.0 -3.6
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 1.3 0.7 0.4 -0.1 -1.1
Angina 0.4 0.6 1.5 -1.2 0.1 0.6 -0.7
Medication for hormone replacement therapy 1.1 1.3 2.4 -0.3 -1.4 -1.5 0.8
Vitamin and mineral supplements 1.4 1.9 3.1 0.8 1.5 1.8 -1.3
Supplements: Zinc 1.5 1.7 2.1 -1.5 -1.3 -1.3 1.1
Medication: Co-codamol 0.1 0.1 0.4 -0.1 0.4 0.6 -0.1
Medication: Metformin 0.2 0.3 1.2 1.1 0.2 -0.2 0.1
Diabetes (father) 1.2 1.4 2.8 0.4 1.7 1.2 -1.1
Diabetes (mother) 1.0 1.3 2.3 0.1 1.3 1.5 -1.1
Severe depression (siblings) 0.4 0.4 1.1 -0.3 0.5 1.1 0.3
Pack years adult smoking proportion 0.4 0.6 1.2 -1.0 -0.3 -0.5 1.1
Impedance of leg (right) 6.0 29.2 47.2 4.7 6.9 6.1 -3.3
Leg fat-free mass (left) 2.5 13.1 23.6 -1.9 -4.9 -4.4 2.4
Trunk fat percentage 5.9 23.7 34.7 4.2 5.6 5.9 -3.3
Hand grip strength (right) 1.5 4.1 6.9 -1.0 -2.4 -2.6 1.7
Townsend deprivation index at recruitment 3.2 4.5 6.0 1.3 2.4 2.1 -2.4
Current tobacco smoking 0.3 0.4 1.5 0.4 1.2 0.1 -0.0
Average weekly fortified wine intake 0.1 0.1 0.2 -0.0 -0.4 0.2 0.2
Maternal smoking around birth 1.5 2.1 3.7 1.5 1.9 1.5 -0.7
Fed-up feelings 1.5 2.7 4.7 1.2 2.2 1.8 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 2.8 0.9 1.7 1.1 -1.0
Relative age voice broke 3.4 5.2 8.7 -1.2 -2.4 -2.2 3.0
Taking other prescription medications 2.0 3.1 5.3 1.4 2.1 2.3 -0.8
Age when periods started (menarche) 0.5 1.1 3.5 -1.9 0.4 0.8 0.5
Bilateral oophorectomy (both ovaries removed) 1.6 1.8 4.1 2.0 1.5 0.8 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 3.0 1.7 0.4 0.9 -1.1
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 3.6 -1.9 -0.2 -0.1 1.8
Qualifications: CSEs or equivalent 0.5 0.6 2.0 0.2 0.7 0.0 -1.4
Serious illness, injury or assault to yourself 1.8 2.1 3.4 1.7 1.0 1.2 -1.8
High blood pressure 2.8 7.8 17.6 0.6 3.1 4.2 -1.8
Hayfever, allergic rhinitis or eczema 0.8 1.7 3.6 0.5 1.7 1.9 -0.1
Multivitamins +/- minerals 0.4 0.5 1.1 0.4 -0.7 -1.0 0.5
Stomach or abdominal pain in last month 0.2 0.3 1.0 1.0 -0.0 -0.1 -0.3
Supplements: Glucosamine 0.9 1.2 2.4 1.5 -0.5 -1.1 0.9
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.3 -0.3 1.1 1.0 0.1
Medication: Atenolol 0.4 0.5 1.1 -0.0 0.9 1.0 -0.2
Medication: Levothyroxine sodium 0.1 0.2 0.5 -0.7 0.1 -0.3 -0.2
Sitting height 2.6 18.7 25.8 -2.3 -5.1 -4.8 4.6
Chronic bronchitis/emphysema (father) 2.1 2.5 6.5 2.5 0.8 0.7 -1.5
High blood pressure (mother) 1.1 1.5 4.4 -2.1 0.6 1.1 0.4
Body mass index (BMI) 0.1 0.5 1.2 1.1 0.4 0.7 -0.3
Impedance of leg (left) 5.7 27.8 47.3 4.5 6.9 5.9 -3.1
Leg predicted mass (left) 2.4 12.9 23.4 -1.8 -4.8 -4.4 2.4
Trunk fat mass 1.8 7.6 10.4 3.0 2.9 3.2 -1.7
Waist circumference 0.4 1.6 4.3 2.1 1.1 0.9 -0.3
Number of incorrect matches in round 0.2 0.3 0.7 -0.8 -0.5 -0.1 0.6
Past tobacco smoking 0.3 0.5 1.9 -1.4 -0.5 -0.0 -0.1
Alcohol usually taken with meals 1.4 2.2 4.0 -0.7 -2.0 -1.3 1.6
Nervous feelings 6.0 11.3 18.1 1.6 4.1 4.2 -2.8
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 3.4 1.9 1.4 0.6 -0.9
Hearing difficulty/problems with background noise 1.0 1.6 6.0 2.5 -0.2 -0.1 0.4
Hair/balding pattern: Pattern 2 1.0 1.3 3.4 0.0 1.3 1.8 -0.0
Had menopause 0.3 0.3 0.8 0.9 0.1 -0.3 0.6
Had other major operations 0.9 1.1 2.1 1.4 0.9 0.8 -1.0
Forced vital capacity (FVC) 0.5 1.9 2.2 -1.4 -1.0 -1.5 1.5
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 2.1 1.1 0.4 0.6 -1.4
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.3 0.5 -0.1 -0.3 -0.6
Qualifications: None of the above 0.7 1.5 2.3 -0.1 -1.2 -1.5 1.5
Financial difficulties in last 2 years 0.3 0.5 0.9 0.1 0.7 0.7 -0.9
Mouth/teeth dental problems 2.4 3.7 9.9 -3.1 -1.8 -1.0 0.9
Heart attack 0.7 0.9 2.7 -0.6 -0.8 -1.6 0.2
Allergy 0.5 1.2 2.1 -1.2 -1.2 -1.4 0.1
Pain all over the body in last month 0.7 0.7 1.1 -0.1 -0.9 -0.9 1.0
Diabetes (self-reported) 1.8 2.7 5.4 2.3 1.8 1.1 -1.1
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.7 -0.5 0.2 0.8 -0.3
Medication: Ramipril 0.2 0.3 0.6 -0.7 -0.3 -0.6 0.3
Medication: Simvastatin 0.1 0.1 0.5 -0.3 -0.1 0.1 0.7
Fluid intelligence score 0.5 0.9 3.2 -0.6 0.2 0.4 1.8
Illnesses of siblings 0.3 0.4 0.7 0.5 -0.8 -0.7 -0.3
Neuroticism score 6.9 14.5 23.3 2.4 4.8 4.5 -2.9
Weight 0.4 1.7 3.1 0.6 -1.8 -1.5 1.2
Impedance of arm (right) 8.6 40.2 64.5 3.2 8.0 8.0 -4.7
Arm fat percentage (right) 3.9 15.4 24.2 3.1 4.4 4.9 -2.8
Trunk fat-free mass 7.3 41.8 68.2 -3.2 -8.3 -7.9 5.1
Hip circumference 2.1 9.2 13.7 -1.9 -3.7 -3.0 3.2
Time employed in main current job 0.3 0.3 1.0 0.6 0.1 -0.1 -1.0
Alcohol intake versus 10 years previously 0.1 0.2 0.4 0.4 -0.5 -0.7 -0.0
Father’s age at death 1.1 1.4 2.9 -0.8 -1.7 -1.2 0.9
Worrier / anxious feelings 3.5 6.6 10.9 0.8 3.1 3.3 -2.3
Frequency of tiredness / lethargy in last 2 weeks 2.5 4.1 6.5 2.5 2.4 1.3 -1.6
Falls in the last year 2.7 3.7 6.2 1.1 2.5 2.1 -1.8
Hair/balding pattern: Pattern 3 1.8 2.7 3.4 1.4 1.8 1.5 -1.7
Number of live births 0.3 0.4 1.2 0.1 1.1 0.6 -0.4
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.5 -0.2 1.2 0.8 -0.6
Pulse rate 2.7 4.5 8.3 1.6 2.0 1.8 -2.9
Happiness 3.2 3.9 7.1 0.8 2.0 2.7 -1.9
Noisy workplace 0.3 0.4 1.2 -0.2 -0.5 -1.1 -0.3
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.1 0.4 -1.0 -1.0 0.3
Serious illness, injury or assault of a close relative in last 2 years 2.5 2.9 3.9 1.8 1.6 1.3 -2.0
Mouth/teeth dental problems: Dentures 0.9 1.4 4.9 2.2 0.5 -0.4 -0.7
Asthma 0.1 0.3 0.6 0.4 0.1 0.8 0.5
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 4.3 -0.0 -1.0 -2.1 -0.2
Medication: Cholesterol lowering 0.3 0.5 1.1 -0.3 -0.6 -1.0 0.8
Depression (self-reported) 0.2 0.3 0.8 0.3 -0.4 0.0 0.9
Medication: Lansoprazole 1.5 1.7 4.7 2.2 1.0 1.1 -0.3
Prospective memory result 0.8 0.9 1.1 -1.0 -1.0 -0.8 1.0
Lung cancer (father) 2.5 3.0 4.7 0.8 2.2 1.9 -1.7
Illnesses of mother 0.1 0.2 0.3 0.4 -0.5 -0.5 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 1.6 -1.3 0.4 -0.2 0.5
Pulse wave Arterial Stiffness index 0.8 1.0 1.9 0.5 1.1 0.6 -1.4
Impedance of arm (left) 8.0 37.1 61.6 3.0 7.7 7.9 -4.4
Arm fat mass (right) 0.6 2.6 3.6 1.9 1.6 1.9 -0.9
Trunk predicted mass 7.3 41.6 67.6 -3.1 -8.2 -8.0 5.1
Standing height 1.7 16.7 27.0 -1.3 -5.1 -5.2 3.5
Length of working week for main job 0.1 0.1 0.2 0.4 0.2 0.1 -0.5
Exposure to tobacco smoke at home 1.0 1.1 2.3 -0.2 -1.5 -1.5 0.3
Breastfed as a baby 0.5 0.6 1.2 -1.1 0.5 0.8 -0.6
Tense / ‘highly strung’ 3.3 5.5 7.3 2.6 2.7 2.5 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 2.3 3.5 5.3 2.3 1.7 1.8 -1.7
Hair/balding pattern: Pattern 4 0.8 2.0 3.2 -0.3 1.3 1.8 -1.7
Birth weight of first child 0.4 0.7 1.4 0.1 -1.1 -1.2 -0.1
Peak expiratory flow (PEF) 1.5 3.4 6.5 0.2 2.5 2.1 -1.6
Pulse wave reflection index 2.5 3.0 4.8 1.7 2.2 1.1 -1.8
Ever highly irritable/argumentative for 2 days 0.9 1.1 2.6 0.3 1.0 1.6 -0.7
Loud music exposure frequency 0.0 0.0 0.1 0.3 0.1 0.2 0.2
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 0.9 -0.4 0.9 0.9 -0.7
Mouth/teeth dental problems: Bleeding gums 0.7 1.0 2.4 1.6 0.6 0.6 -0.9
Blood clot in the leg (DVT) 0.0 0.0 0.1 0.2 -0.1 -0.1 -0.2
Medication: Paracetamol 1.1 1.8 3.3 1.2 1.8 1.3 -0.9
Headache pain in last month 0.5 0.9 2.0 1.1 -0.1 -1.4 0.5
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.2 0.2 -0.1 0.0 0.4
Glaucoma (self-reported) 0.7 0.9 1.3 0.6 1.0 1.1 -0.8
Gout (self-reported) 0.3 0.4 0.9 -0.3 0.5 0.9 -0.4
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.7 -0.9 0.2 -0.5 0.3
Medication: Amlodipine 0.5 0.6 1.7 0.3 0.9 1.3 -0.0
Medication: Ventolin 100micrograms inhaler 1.7 2.2 5.1 0.8 1.7 2.2 -0.3
Birth weight 5.2 11.3 18.1 -2.3 -4.3 -3.8 2.8
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.0 0.7 0.7 1.4 -0.6
High blood pressure (siblings) 0.9 1.3 2.4 -0.2 1.5 1.6 -0.8
Forced vital capacity (FVC), Best measure 1.2 4.4 6.2 -2.5 -1.7 -2.0 2.1
Body fat percentage 5.9 23.4 33.3 4.2 5.5 5.8 -3.4
Leg fat percentage (right) 5.3 19.4 26.1 4.3 5.0 5.1 -2.8
Arm fat-free mass (right) 5.3 27.1 44.0 -2.0 -6.6 -6.6 4.1
Exposure to tobacco smoke outside home 1.0 1.4 3.3 1.8 0.8 1.2 -0.1
Comparative body size at age 10 0.3 0.9 2.0 -0.9 -1.0 -1.4 0.1
Number of full brothers 1.4 1.8 3.4 -1.8 -0.8 -0.5 1.7
Worry too long after embarrassment 3.5 5.9 10.7 0.8 2.8 3.3 -2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.3 0.8 0.9 0.4 0.6 -0.2
Wheeze or whistling in the chest in last year 0.2 0.4 1.5 -0.0 0.4 1.2 0.2
Number of children fathered 0.2 0.3 1.0 1.0 0.0 0.2 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.6 1.1 0.5 1.3 0.2
Age at first live birth 3.2 5.7 7.8 -2.8 -2.7 -1.8 2.0
Pulse wave peak to peak time 1.3 1.6 3.0 -0.5 -1.4 -1.0 1.7
Health satisfaction 3.1 4.0 6.0 1.5 2.1 2.5 -1.9
Shortness of breath walking on level ground 3.1 3.7 6.0 0.8 2.3 2.5 -1.7
Qualifications: College or University degree 0.2 0.5 1.7 0.1 -0.5 0.3 1.3
Eye problems/disorders: None of the above 4.3 5.0 5.5 -2.3 -2.3 -2.3 2.0
Mouth/teeth dental problems: Loose teeth 1.8 2.2 3.3 1.5 1.8 1.7 -0.6
Emphysema/chronic bronchitis 0.5 0.5 0.8 -0.3 -0.8 -0.9 0.8
Medication for pain relief, constipation, heartburn 0.3 0.5 1.2 0.3 0.5 1.1 -0.5
Neck or shoulder pain in last month 0.2 0.3 0.6 0.7 0.5 0.8 0.0
Medication: Blood pressure 0.1 0.2 0.7 -0.1 -0.1 -0.0 -0.9
Angina (self-reported) 0.6 0.8 1.9 -1.4 0.3 0.8 -0.6
Migraine (self-reported) 0.5 0.6 1.0 0.5 1.0 -0.3 -1.0
Medication: Ibuprofen 1.4 1.7 4.5 -0.6 -1.3 -2.1 0.3
Medication: Allopurinol 0.5 0.7 2.1 0.1 0.9 1.4 -0.3
Medication: Omeprazole 0.8 1.0 2.8 1.7 0.9 0.4 0.1
Medication: Seretide 50 evohaler 0.0 0.1 0.1 0.1 -0.4 0.2 0.1
Mean time to correctly identify matches 0.2 0.3 0.7 -0.1 0.1 0.7 -0.8
Heart disease (mother) 3.2 3.9 6.1 1.1 2.5 2.3 -1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 2.6 0.6 1.3 1.6 -0.9
Whole body fat mass 1.4 5.8 7.8 2.7 2.5 2.8 -1.4
Leg fat mass (right) 1.2 4.7 7.6 2.8 2.1 2.3 -1.2
Arm predicted mass (right) 5.1 26.1 42.4 -1.9 -6.5 -6.5 4.0
Pulse rate, automated reading 4.6 15.0 29.4 2.7 3.8 3.1 -5.4
Alcohol intake frequency. 0.8 1.8 4.6 -0.1 -1.6 -2.1 0.3
Comparative height size at age 10 0.4 2.0 3.8 1.4 -1.4 -1.9 -0.5
Number of full sisters 0.2 0.2 0.4 0.1 -0.4 -0.6 0.6
Suffer from ‘nerves’ 3.8 5.9 7.1 2.2 2.7 2.4 -2.5
Overall health rating 2.5 5.5 8.9 2.4 2.2 1.5 -3.0
Chest pain or discomfort 1.7 2.5 4.5 1.5 1.8 2.1 -0.4
Had major operations 1.3 1.5 3.0 -0.0 1.3 1.7 -1.2
Age at last live birth 1.6 2.3 6.0 -2.4 -0.9 -0.5 1.5
Family relationship satisfaction 0.4 0.5 1.3 0.5 0.6 1.1 -0.5
Leg pain on walking 0.7 0.8 2.3 -1.0 -0.4 -0.1 1.5
Qualifications: NVQ or HND or HNC or equivalent 2.8 3.4 5.2 2.1 1.6 1.2 -2.3
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.6 0.8 0.2 -0.1 0.3
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 4.5 -2.1 -0.3 -0.1 1.3
Medication: Aspirin 0.3 0.4 1.1 -1.1 0.0 0.5 0.2
Supplements: Vitamin C 0.3 0.4 0.7 -0.9 -0.4 -0.6 0.5
Knee pain experienced in last month 1.0 1.5 3.3 1.0 1.3 1.8 -0.2
Hypertension (Self-reported) 3.1 8.5 18.5 0.7 3.3 4.3 -2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.7 1.6 0.2 0.4 -0.2
Illnesses of father: Heart disease 0.7 1.0 2.1 1.5 -0.1 -0.7 -1.2
Illnesses of siblings: Diabetes 3.9 4.7 6.1 2.0 2.5 2.1 -2.1
Smoking status: Previous 0.0 0.1 0.3 0.5 -0.0 0.0 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.4 5.3 0.6 -2.0 -2.3 0.4
Whole body fat-free mass 5.5 31.2 52.1 -2.8 -7.2 -6.9 4.2
Leg fat-free mass (right) 3.0 16.1 27.9 -2.4 -5.3 -4.9 2.7
Arm fat percentage (left) 3.8 15.0 24.9 2.9 4.4 5.0 -2.7
Average weekly red wine intake 0.8 1.2 3.0 0.6 -0.7 -1.0 1.7
Handedness (chirality/laterality): Left-handed 2.0 2.4 7.3 2.7 -0.7 -0.7 -1.1
Mood swings 1.3 2.4 3.7 1.0 1.9 1.6 -1.5
Loneliness, isolation 0.8 1.0 1.7 0.5 1.1 0.9 -1.3
Long-standing illness, disability or infirmity 1.3 2.0 6.6 2.6 0.6 0.2 -1.1
Ever had bowel cancer screening 0.2 0.3 0.8 0.5 0.0 0.2 -0.9
Diabetes diagnosed by doctor 1.1 1.8 3.8 1.9 1.4 0.7 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.2 0.4 -0.7 -0.4 0.1 0.1
Friendships satisfaction 0.9 1.2 3.2 0.2 1.1 1.8 -0.5
Qualifications: nursing, teaching 0.5 0.7 1.2 -0.7 -1.0 -0.3 1.1
Commuting to job workplace: Walk 0.3 0.3 1.1 -1.0 -0.1 0.1 0.1
Eye problems/disorders: Cataract 3.2 3.7 6.9 1.4 1.7 1.8 -2.6
Mouth/teeth dental problems: Mouth ulcers 2.4 3.9 10.8 3.3 1.6 1.1 -0.9
Medication for cholesterol 0.9 1.4 3.5 0.1 -1.4 -1.9 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 4.0 -1.1 -0.9 -0.7 2.0
Back pain experienced in last month 0.8 1.2 3.7 1.9 0.9 -0.2 0.4
Mineral and other dietary supplements 0.4 0.6 1.3 0.2 0.9 1.1 -0.1
Breast cancer (self-reported) 1.4 1.7 3.6 -0.3 1.1 1.4 -1.9
Asthma (self-reported) 0.1 0.2 0.5 0.3 0.0 0.7 0.6
Osteoporosis (self-reported) 1.0 1.3 2.7 0.4 -1.1 -1.7 1.0
Osteoarthritis (self-reported) 1.0 1.3 2.6 1.6 1.1 1.0 -0.6
Medication: Aspirin 0.3 0.4 0.9 -1.0 0.2 0.8 0.1
Medication: Gliclazide 1.0 1.2 2.1 1.4 1.1 0.6 -1.0
Illnesses of father: None of the above (group 1) 0.2 0.3 0.7 -0.8 0.3 0.5 -0.1
Smoking status: Current 0.3 0.4 1.3 0.4 1.2 0.0 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.3 -0.3 1.1 0.4 -0.0
Whole body water mass 5.5 31.5 52.9 -2.7 -7.3 -7.0 4.1
Leg predicted mass (right) 2.9 15.3 26.5 -2.3 -5.2 -4.8 2.6
Arm fat mass (left) 0.7 2.7 3.8 1.8 1.7 2.0 -0.9
Number of self-reported non-cancer illnesses 1.6 2.7 4.5 1.4 1.9 2.1 -0.9
Average weekly champagne plus white wine intake 0.4 0.5 0.8 -0.9 -0.3 0.7 0.7
Miserableness 2.7 4.7 7.5 1.6 2.7 2.4 -1.7
Guilty feelings 1.7 2.6 4.2 1.7 2.1 1.5 -1.1
Wears glasses or contact lenses 1.6 1.8 3.8 1.9 1.3 1.4 0.1
Ever taken oral contraceptive pill 1.1 1.2 1.6 0.7 1.1 1.2 -1.2
Hearing aid user 3.7 4.2 7.7 -0.1 -2.8 -2.7 1.4
Mother’s age at death 0.2 0.3 0.6 -0.8 0.2 0.4 -0.7
Financial situation satisfaction 0.1 0.2 0.3 -0.3 0.3 0.5 -0.5
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.3 -0.5 0.4 0.1 0.3
Commuting to job workplace: Public transport 0.2 0.2 0.4 0.1 0.6 0.3 -0.6
Eye problems/disorders: Glaucoma 1.5 1.8 3.6 0.3 1.9 1.9 -0.4
Medication: Blood pressure 4.6 8.7 18.4 1.3 3.6 4.3 -1.3
Pain type(s) experienced in last month: Hip pain 1.3 1.7 3.1 1.2 1.8 1.3 -0.6
Supplements: Fish oil (including cod liver oil) 1.0 1.3 2.2 -0.5 -1.5 -1.5 0.9
High cholesterol (Self-reported) 0.6 1.0 1.3 -1.1 -0.9 -0.9 1.0
Medication: Bendroflumethiazide 1.2 1.8 5.2 -0.1 1.4 2.3 -0.0
Medication: Paracetamol 1.5 2.3 4.4 1.2 2.1 1.3 -1.2
Medication: Lisinopril 2.6 3.3 7.2 0.8 2.2 2.7 -0.9
Medication: Atorvastatin 0.5 0.6 1.0 -1.0 0.6 0.9 0.2
Illnesses of father: High blood pressure 2.1 2.6 4.8 -1.4 -1.6 -1.1 2.2
Alcohol drinker status: Never 1.4 1.7 3.0 -0.4 -1.7 -1.6 0.9
Ever smoked 0.3 0.5 1.1 1.0 0.8 0.3 -0.0
Basal metabolic rate 3.6 20.0 34.1 -2.0 -5.8 -5.5 3.4
Leg fat percentage (left) 4.7 16.9 22.8 4.0 4.8 4.7 -2.5
Arm fat-free mass (left) 4.9 25.1 41.2 -1.7 -6.4 -6.4 3.9
Number of operations (self-reported) 1.2 1.8 3.5 1.9 0.9 1.0 -1.3
Average weekly beer plus cider intake 3.8 5.5 10.8 0.8 2.6 3.3 -2.0
Irritability 3.5 6.0 9.1 1.9 2.7 3.0 -1.9
Risk taking 0.8 1.2 2.0 -1.1 -0.3 -1.2 1.4
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.7 0.4 -1.3 -1.0 0.4
Fractured/broken bones in last 5 years 0.2 0.2 0.6 0.0 0.2 0.7 0.4
Age started oral contraceptive pill 0.3 0.4 0.9 -0.0 0.8 0.9 -0.2
Diastolic blood pressure, automated reading 7.1 22.0 50.7 -0.4 4.5 7.1 -4.1
Ever depressed for a whole week 0.2 0.2 0.4 0.3 -0.6 -0.5 -0.3
Unable to work because of sickness or disability 2.3 3.0 7.5 2.7 1.5 0.5 -1.5
Commuting to job workplace: Cycle 0.0 0.0 0.1 -0.2 0.2 -0.2 -0.2
Myopia 0.7 1.0 2.8 1.1 0.1 -0.2 -1.7
Vascular/heart problems diagnosed by doctor 1.8 4.9 11.4 0.0 -2.4 -3.4 1.5
Cholesterol lowering medication 0.5 0.7 1.8 -1.4 -0.2 0.6 0.7
Medication: Omeprazole (e.g. Zanprol) 1.7 2.0 5.6 2.4 1.2 1.0 -0.2
Pain experienced in last month 1.8 2.9 6.7 -2.6 -1.7 -1.1 1.0
Supplements: Calcium 2.7 2.9 5.1 -1.2 -1.9 -2.2 1.2
Basal cell carcinoma (self-reported) 2.2 2.6 3.6 0.6 1.9 1.7 -1.8
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.5 -0.4 -0.3 -1.2 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.3 0.4 0.0 0.1 -0.5
Heart disease (siblings) 0.6 0.7 1.3 -0.4 -1.1 -1.0 0.4
Alcohol drinker status: Previous 0.2 0.2 0.3 0.2 -0.5 -0.5 0.6
Pack years of smoking 0.4 0.6 1.1 -0.9 -0.3 -0.5 1.0
Impedance of whole body 8.7 44.2 71.5 4.3 8.5 8.0 -4.7
Leg fat mass (left) 1.0 3.9 7.0 2.6 1.9 2.0 -1.1
Arm predicted mass (left) 4.7 24.0 39.6 -1.6 -6.3 -6.3 3.8