Best TWAS P=2.98e-11 · Best GWAS P=8.61e-12 conditioned to 0.000331
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FAM177A1 | 0.07 | 0.05 | bslmm | 383 | 0.04 | 7.3e-06 | 5.0 | -5.9 | 4.0e-09 | 0.40 | 0.50 | 0.44 | FALSE |
2 | GTEx | Adipose Subcutaneous | PPP2R3C | 0.21 | 0.12 | lasso | 10 | 0.14 | 2.6e-11 | 5.5 | -5.2 | 1.8e-07 | 0.34 | 0.94 | 0.06 | FALSE |
3 | GTEx | Artery Tibial | RP11-85K15.2 | 0.06 | 0.01 | lasso | 6 | 0.02 | 2.1e-02 | 5.0 | 6.3 | 4.1e-10 | -0.69 | 0.10 | 0.47 | FALSE |
4 | GTEx | Brain Cerebellum | FAM177A1 | 0.13 | 0.04 | lasso | 3 | 0.04 | 1.9e-02 | 6.5 | -6.6 | 3.0e-11 | 0.59 | 0.03 | 0.72 | TRUE |
5 | GTEx | Esophagus Mucosa | SRP54 | 0.13 | 0.05 | lasso | 5 | 0.05 | 1.6e-04 | 5.5 | -5.8 | 7.2e-09 | 0.40 | 0.08 | 0.84 | FALSE |
6 | GTEx | Lung | RP11-85K15.2 | 0.12 | 0.08 | lasso | 6 | 0.06 | 4.4e-05 | -6.1 | 5.4 | 6.2e-08 | -0.81 | 0.18 | 0.80 | FALSE |
7 | GTEx | Nerve Tibial | SRP54 | 0.16 | 0.02 | enet | 14 | 0.08 | 1.3e-06 | 1.4 | 5.4 | 7.4e-08 | -0.73 | 0.03 | 0.96 | FALSE |
8 | GTEx | Nerve Tibial | FAM177A1 | 0.23 | 0.07 | enet | 37 | 0.10 | 1.1e-07 | 6.5 | -5.3 | 1.2e-07 | 0.50 | 0.03 | 0.97 | FALSE |
9 | GTEx | Testis | FAM177A1 | 0.30 | 0.16 | lasso | 5 | 0.23 | 1.2e-10 | 3.6 | 5.5 | 3.6e-08 | -0.50 | 0.18 | 0.82 | FALSE |
10 | NTR | Blood | KIAA0391 | 0.05 | 0.05 | lasso | 10 | 0.05 | 2.4e-15 | 5.5 | 5.5 | 3.9e-08 | -0.29 | 0.92 | 0.08 | FALSE |
11 | YFS | Blood | KIAA0391 | 0.29 | 0.36 | lasso | 7 | 0.38 | 5.8e-132 | 5.5 | 5.4 | 5.2e-08 | -0.35 | 0.92 | 0.08 | FALSE |