[Hub]/) : Traits : Impedance of arm (left) : ← →

chr15:76,398,193-78,806,023

Best TWAS P=4.97e-19 · Best GWAS P=3.28e-17 conditioned to 0.0503

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
8	GTEx	Artery Tibial	TSPAN3	0.14	0.07	lasso	5	0.10	1.6e-08	8.2	-8.9	5.0e-19	-0.82	0.02	0.98	TRUE
19	GTEx	Brain Hypothalamus	RP11-797A18.4	0.21	0.18	lasso	7	0.22	7.6e-06	7.9	-8.4	5.4e-17	-0.92	0.01	0.98	FALSE
26	GTEx	Cells Transformed fibroblasts	RP11-797A18.4	0.12	0.11	lasso	8	0.12	4.0e-09	7.7	-8.2	2.6e-16	-0.86	0.02	0.98	FALSE
43	GTEx	Skin Sun Exposed Lower leg	RP11-797A18.4	0.16	0.08	enet	23	0.09	1.3e-07	7.7	-8.2	3.0e-16	-0.84	0.04	0.96	FALSE
31	GTEx	Esophagus Muscularis	RP11-797A18.4	0.07	0.09	lasso	3	0.09	6.3e-06	8.2	-8.2	3.3e-16	-0.87	0.02	0.98	FALSE
41	GTEx	Skin Not Sun Exposed Suprapubic	RP11-797A18.4	0.19	0.10	enet	31	0.15	8.0e-09	7.9	-8.2	3.7e-16	-0.72	0.13	0.87	FALSE
38	GTEx	Nerve Tibial	TSPAN3	0.13	0.08	lasso	2	0.07	9.0e-06	8.2	-8.1	4.1e-16	-0.85	0.01	0.99	FALSE
44	GTEx	Testis	PSTPIP1	0.10	0.03	lasso	3	0.02	4.1e-02	7.9	-7.8	4.3e-15	-0.81	0.05	0.80	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TSPAN3	0.05	0.01	blup	43	0.01	1.5e-02	7.7	-7.8	7.2e-15	-0.78	0.01	0.47	FALSE
33	GTEx	Heart Left Ventricle	RP11-797A18.4	0.16	0.09	enet	12	0.08	3.3e-05	8.2	-7.7	1.1e-14	-0.84	0.02	0.98	FALSE
10	GTEx	Artery Tibial	RP11-797A18.4	0.14	0.03	enet	25	0.09	2.3e-07	7.6	-7.7	1.3e-14	-0.66	0.06	0.94	FALSE
12	GTEx	Brain Caudate basal ganglia	RP11-797A18.4	0.21	0.14	lasso	5	0.12	2.9e-04	7.7	-7.6	2.7e-14	-0.81	0.08	0.83	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	RP11-797A18.4	0.12	0.22	lasso	1	0.17	3.1e-05	7.6	-7.6	2.8e-14	-0.80	0.07	0.68	FALSE
7	GTEx	Artery Coronary	RP11-797A18.3	0.12	0.03	lasso	10	0.01	1.1e-01	-4.4	-7.5	8.5e-14	-0.80	0.04	0.50	FALSE
55	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TSPAN3	0.05	0.00	enet	7	0.02	9.7e-03	7.6	-7.5	9.2e-14	-0.71	0.01	0.73	FALSE
17	GTEx	Brain Cortex	RP11-797A18.4	0.47	0.28	enet	14	0.34	3.3e-10	7.9	-7.4	1.2e-13	-0.81	0.03	0.97	FALSE
35	GTEx	Lung	RP11-797A18.4	0.19	0.09	enet	21	0.17	3.5e-13	7.6	-7.4	1.2e-13	-0.68	0.13	0.87	FALSE
18	GTEx	Brain Frontal Cortex BA9	RP11-797A18.4	0.35	0.35	lasso	5	0.35	4.8e-10	7.6	-7.4	1.3e-13	-0.79	0.19	0.81	FALSE
25	GTEx	Cells Transformed fibroblasts	TSPAN3	0.17	0.16	lasso	3	0.17	1.7e-12	8.2	-7.4	1.4e-13	-0.84	0.01	0.99	FALSE
37	GTEx	Muscle Skeletal	RP11-797A18.4	0.14	0.14	lasso	6	0.18	6.6e-17	7.7	-7.2	5.7e-13	-0.81	0.05	0.95	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	TSPAN3	0.03	0.01	blup	43	0.01	8.2e-03	5.3	-7.2	6.7e-13	-0.68	0.03	0.64	FALSE
21	GTEx	Brain Putamen basal ganglia	RP11-797A18.4	0.27	0.06	lasso	5	0.06	1.7e-02	7.7	-7.2	7.2e-13	-0.77	0.03	0.44	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	RP11-797A18.3	0.15	0.08	lasso	3	0.09	1.2e-05	-4.4	-7.2	7.2e-13	-0.78	0.16	0.79	FALSE
53	NTR	Blood	TSPAN3	0.07	0.08	lasso	9	0.09	5.1e-27	7.6	-7.2	7.5e-13	-0.79	0.43	0.57	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	RP11-797A18.4	0.14	0.11	enet	10	0.15	6.0e-06	4.9	-7.2	8.7e-13	-0.81	0.02	0.97	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	PSTPIP1	0.13	0.04	enet	13	0.10	4.0e-04	6.0	-7.1	1.0e-12	-0.73	0.08	0.75	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-797A18.4	0.06	0.05	lasso	3	0.06	4.1e-04	7.6	-7.1	1.5e-12	-0.78	0.06	0.83	FALSE
27	GTEx	Cells Transformed fibroblasts	RP11-797A18.6	0.07	0.06	lasso	4	0.06	2.2e-05	8.2	-7.1	1.6e-12	-0.77	0.01	0.98	FALSE
11	GTEx	Brain Caudate basal ganglia	PSTPIP1	0.22	0.12	lasso	9	0.13	1.4e-04	7.9	7.0	2.3e-12	0.80	0.03	0.92	FALSE
42	GTEx	Skin Sun Exposed Lower leg	TSPAN3	0.11	0.03	enet	8	0.10	2.5e-08	-6.3	-7.0	2.5e-12	-0.68	0.08	0.84	FALSE
15	GTEx	Brain Cerebellum	HMG20A	0.14	0.03	enet	7	0.10	6.4e-04	7.9	-6.9	4.3e-12	-0.73	0.04	0.71	FALSE
3	GTEx	Adipose Subcutaneous	RP11-797A18.4	0.19	0.12	lasso	8	0.16	2.1e-13	-4.5	-6.9	4.4e-12	-0.79	0.78	0.22	FALSE
28	GTEx	Colon Transverse	RP11-797A18.4	0.15	0.03	lasso	5	0.05	3.1e-03	-4.5	-6.9	4.7e-12	-0.77	0.04	0.89	FALSE
16	GTEx	Brain Cerebellum	RP11-797A18.4	0.29	0.20	lasso	9	0.25	4.0e-08	7.9	-6.8	1.0e-11	-0.78	0.07	0.89	FALSE
34	GTEx	Lung	RP11-797A18.3	0.05	0.03	enet	8	0.04	3.4e-04	-4.4	-6.8	1.1e-11	-0.79	0.08	0.80	FALSE
48	GTEx	Whole Blood	TSPAN3	0.05	0.04	lasso	2	0.03	1.8e-03	-6.3	-6.7	2.5e-11	-0.55	0.11	0.35	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	RP11-797A18.4	0.16	0.08	lasso	6	0.14	2.7e-05	-4.4	-6.7	2.7e-11	-0.77	0.09	0.80	FALSE
45	GTEx	Testis	TSPAN3	0.19	0.05	lasso	7	0.06	1.6e-03	7.6	-6.6	3.3e-11	-0.72	0.05	0.84	FALSE
14	GTEx	Brain Cerebellar Hemisphere	RP11-797A18.4	0.14	0.12	enet	10	0.12	6.4e-04	4.9	-6.6	4.8e-11	-0.75	0.06	0.63	FALSE
6	GTEx	Artery Aorta	RP11-797A18.4	0.13	0.11	enet	17	0.12	2.3e-07	-4.5	-6.6	5.1e-11	-0.76	0.18	0.81	FALSE
5	GTEx	Adrenal Gland	RP11-797A18.4	0.13	0.04	enet	18	0.11	1.1e-04	-4.4	-6.5	5.8e-11	-0.75	0.04	0.79	FALSE
47	GTEx	Uterus	RP11-797A18.4	0.26	0.11	enet	12	0.16	4.0e-04	8.4	-6.5	9.7e-11	-0.84	0.01	0.90	FALSE
32	GTEx	Heart Atrial Appendage	RP11-797A18.4	0.16	0.06	enet	17	0.11	1.5e-05	7.6	-6.4	1.3e-10	-0.72	0.14	0.82	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	TSPAN3	0.26	0.14	lasso	6	0.12	8.2e-05	-6.3	-6.4	1.6e-10	-0.53	0.14	0.26	FALSE
39	GTEx	Ovary	RP11-797A18.6	0.21	0.04	enet	15	0.13	3.7e-04	8.2	-6.3	2.4e-10	-0.78	0.04	0.61	FALSE
36	GTEx	Muscle Skeletal	HMG20A	0.04	0.00	lasso	4	0.01	7.2e-02	6.1	-6.2	4.1e-10	-0.55	0.03	0.76	FALSE
51	GTEx	Whole Blood	RP11-797A18.6	0.04	0.02	enet	8	0.03	4.9e-04	-4.4	-6.0	2.2e-09	-0.75	0.14	0.40	FALSE
9	GTEx	Artery Tibial	LINGO1	0.08	0.04	lasso	5	0.03	2.7e-03	-5.4	-5.8	8.5e-09	-0.47	0.24	0.18	FALSE
46	GTEx	Testis	RP11-797A18.6	0.09	-0.01	enet	14	0.01	1.7e-01	-4.0	-5.8	8.7e-09	-0.49	0.06	0.29	FALSE
54	YFS	Blood	TSPAN3	0.18	0.14	bslmm	256	0.18	5.9e-57	-4.3	-5.7	1.3e-08	-0.53	1.00	0.00	FALSE
50	GTEx	Whole Blood	RP11-797A18.4	0.21	0.18	enet	26	0.19	1.6e-17	-4.4	-5.7	1.5e-08	-0.64	1.00	0.00	FALSE
13	GTEx	Brain Cerebellar Hemisphere	RP11-797A18.3	0.14	0.03	lasso	6	0.02	7.9e-02	-1.9	-5.6	2.4e-08	-0.66	0.06	0.30	FALSE
52	METSIM	Adipose	PSTPIP1	0.04	0.04	lasso	3	0.04	2.3e-06	-4.2	-5.3	9.5e-08	-0.54	0.59	0.39	FALSE
58	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SCAPER	0.11	0.01	lasso	3	0.01	2.2e-02	4.9	-5.3	1.4e-07	-0.41	0.02	0.68	FALSE
2	GTEx	Adipose Subcutaneous	HMG20A	0.16	0.09	lasso	8	0.09	1.4e-07	-2.2	-5.2	1.8e-07	-0.69	0.10	0.90	FALSE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	SCAPER	0.05	0.02	lasso	3	0.02	7.5e-05	4.9	-5.2	1.8e-07	-0.36	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	HMG20A	0.06	0.03	enet	10	0.06	9.8e-08	-2.2	-5.2	2.2e-07	-0.67	0.13	0.86	FALSE
30	GTEx	Esophagus Mucosa	RP11-797A18.4	0.14	0.05	enet	13	0.08	7.5e-06	-4.5	-5.2	2.3e-07	-0.67	0.09	0.90	FALSE
49	GTEx	Whole Blood	RP11-797A18.3	0.08	0.05	lasso	7	0.05	4.4e-05	-4.4	-5.1	2.9e-07	-0.66	0.30	0.66	FALSE
60	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SCAPER	0.06	0.00	enet	5	0.00	3.4e-01	5.2	-5.1	3.1e-07	-0.32	0.01	0.38	FALSE