Best TWAS P=1.69e-14 · Best GWAS P=1.12e-18 conditioned to 7.82e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | LOXL1-AS1 | 0.28 | 0.09 | lasso | 6 | 0.17 | 1.7e-12 | 4.0 | 6.5 | 1.0e-10 | -0.64 | 0.99 | 0.01 | FALSE |
| 2 | GTEx | Skin Sun Exposed Lower leg | ISLR | 0.08 | 0.00 | enet | 14 | 0.03 | 2.8e-03 | 3.8 | 6.9 | 4.0e-12 | -0.12 | 0.15 | 0.07 | FALSE |
| 3 | GTEx | Testis | LOXL1-AS1 | 0.36 | 0.15 | lasso | 10 | 0.13 | 2.4e-06 | -7.0 | -7.7 | 1.7e-14 | 0.60 | 0.51 | 0.08 | TRUE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ISLR2 | 0.02 | 0.02 | lasso | 2 | 0.01 | 5.4e-04 | -7.5 | -7.5 | 9.4e-14 | 0.17 | 0.00 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ISLR | 0.02 | 0.02 | lasso | 2 | 0.01 | 6.2e-04 | -7.4 | 7.5 | 5.8e-14 | -0.15 | 0.01 | 0.94 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LOC283731 | 0.02 | 0.01 | blup | 15 | 0.01 | 1.9e-03 | -7.5 | -6.8 | 1.4e-11 | 0.20 | 0.00 | 0.88 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | STRA6 | 0.02 | 0.02 | lasso | 2 | 0.02 | 4.5e-05 | -6.6 | 6.5 | 1.0e-10 | -0.09 | 0.09 | 0.50 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC283731 | 0.02 | 0.03 | lasso | 2 | 0.02 | 7.7e-04 | -7.5 | -7.5 | 7.3e-14 | 0.17 | 0.00 | 0.97 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | CCDC33 | 0.05 | 0.02 | blup | 93 | 0.04 | 4.0e-05 | 2.1 | 5.8 | 7.2e-09 | -0.12 | 0.27 | 0.65 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ISLR2 | 0.06 | 0.07 | lasso | 2 | 0.06 | 3.9e-07 | -7.5 | -7.5 | 7.3e-14 | 0.17 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC283731 | 0.02 | 0.03 | lasso | 3 | 0.02 | 1.5e-03 | -7.3 | -7.4 | 1.3e-13 | 0.17 | 0.00 | 0.95 | FALSE |
| 12 | The Cancer Genome Atlas | Thyroid Carcinoma | ISLR2 | 0.04 | 0.05 | lasso | 2 | 0.04 | 6.5e-05 | -7.5 | -7.5 | 7.0e-14 | 0.16 | 0.00 | 0.99 | FALSE |
| 13 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC283731 | 0.04 | 0.06 | lasso | 1 | 0.05 | 4.8e-06 | -7.3 | -7.3 | 2.1e-13 | 0.16 | 0.00 | 1.00 | FALSE |