Best TWAS P=1.02e-10 · Best GWAS P=9.99e-14 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FIBP | 0.08 | 0.11 | enet | 20 | 0.12 | 8.1e-14 | 4.7 | 6.1 | 1.1e-09 | -0.34 | 1.00 | 0.00 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SNX32 | 0.46 | 0.36 | lasso | 8 | 0.39 | 1.9e-50 | 5.6 | 5.6 | 2.6e-08 | -0.16 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adrenal Gland | CTSW | 0.13 | 0.08 | lasso | 12 | 0.06 | 3.0e-03 | 4.3 | -5.2 | 1.9e-07 | 0.22 | 0.31 | 0.18 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Male) | LTBP3 | 0.11 | -0.01 | enet | 26 | -0.01 | 5.8e-01 | 4.1 | 5.3 | 1.1e-07 | -0.08 | 0.03 | 0.25 | TRUE |
| 5 | GTEx | Breast Mammary Tissue (Male) | NEAT1 | 0.27 | 0.01 | enet | 29 | 0.03 | 6.3e-02 | 3.9 | 5.6 | 2.1e-08 | -0.16 | 0.04 | 0.26 | FALSE |
| 6 | GTEx | Cells EBV-transformed lymphocytes | FIBP | 0.40 | 0.21 | enet | 26 | 0.29 | 4.3e-10 | 4.7 | 5.1 | 2.7e-07 | -0.17 | 0.99 | 0.00 | FALSE |
| 7 | GTEx | Esophagus Muscularis | CNIH2 | 0.06 | 0.02 | lasso | 8 | 0.02 | 2.8e-02 | 4.0 | 5.2 | 2.6e-07 | -0.53 | 0.09 | 0.56 | TRUE |
| 8 | GTEx | Esophagus Muscularis | CTD-3074O7.5 | 0.22 | 0.02 | enet | 17 | 0.09 | 3.7e-06 | -3.2 | 6.5 | 1.0e-10 | -0.50 | 0.29 | 0.47 | TRUE |
| 9 | GTEx | Heart Atrial Appendage | KLC2 | 0.10 | 0.04 | lasso | 8 | 0.09 | 1.1e-04 | 4.0 | -5.3 | 1.3e-07 | 0.56 | 0.28 | 0.40 | TRUE |
| 10 | GTEx | Heart Atrial Appendage | RP11-867G23.1 | 0.19 | 0.13 | lasso | 5 | 0.11 | 1.6e-05 | -5.6 | -5.7 | 1.3e-08 | 0.66 | 0.12 | 0.80 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | RP11-867G23.1 | 0.06 | 0.06 | enet | 7 | 0.02 | 1.3e-02 | 5.3 | -5.4 | 5.9e-08 | 0.69 | 0.27 | 0.46 | FALSE |
| 12 | GTEx | Thyroid | PACS1 | 0.09 | 0.04 | enet | 16 | 0.09 | 2.8e-07 | -7.2 | -5.8 | 6.3e-09 | 0.79 | 0.02 | 0.98 | TRUE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | SNX32 | 0.50 | 0.53 | lasso | 13 | 0.54 | 1.1e-81 | 5.6 | 5.3 | 1.4e-07 | -0.13 | 1.00 | 0.00 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SNX32 | 0.15 | 0.17 | blup | 60 | 0.17 | 2.9e-34 | 5.6 | 5.3 | 1.4e-07 | -0.16 | 0.00 | 1.00 | TRUE |
| 15 | The Cancer Genome Atlas | Colon Adenocarcinoma | SNX32 | 0.11 | 0.08 | enet | 5 | 0.07 | 9.7e-05 | 4.9 | 5.1 | 2.7e-07 | -0.14 | 0.00 | 1.00 | TRUE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CNIH2 | 0.03 | 0.00 | enet | 4 | 0.02 | 6.4e-03 | -4.8 | 5.3 | 1.2e-07 | -0.58 | 0.06 | 0.13 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FIBP | 0.04 | 0.04 | lasso | 3 | 0.04 | 1.2e-05 | 5.6 | 5.5 | 3.1e-08 | -0.13 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Adenocarcinoma | SNX32 | 0.14 | 0.09 | blup | 60 | 0.13 | 8.8e-15 | 5.6 | 5.4 | 7.9e-08 | -0.16 | 0.01 | 0.99 | FALSE |
| 19 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SNX32 | 0.30 | 0.19 | lasso | 1 | 0.14 | 3.9e-06 | 5.6 | 5.6 | 1.9e-08 | -0.12 | 0.00 | 1.00 | FALSE |
| 20 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SNX32 | 0.12 | 0.13 | blup | 60 | 0.13 | 1.2e-09 | 4.7 | 5.5 | 3.3e-08 | -0.16 | 0.04 | 0.96 | FALSE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | SNX32 | 0.23 | 0.26 | lasso | 7 | 0.25 | 6.4e-24 | 5.6 | 5.4 | 7.4e-08 | -0.14 | 0.00 | 1.00 | FALSE |