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chr15:40,828,922-42,468,786

Best TWAS P=1.3e-09 · Best GWAS P=7.09e-10 conditioned to 0.0617

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	NDUFAF1	0.14	0.16	bslmm	304	0.19	6.6e-23	5.3	-5.3	9.6e-08	-0.71	0.23	0.77	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NUSAP1	0.20	0.24	bslmm	311	0.24	4.6e-29	5.6	5.3	1.1e-07	0.75	0.10	0.90	FALSE
3	GTEx	Adipose Subcutaneous	OIP5-AS1	0.21	0.23	lasso	5	0.26	3.7e-21	5.3	5.7	1.2e-08	0.74	0.16	0.84	FALSE
4	GTEx	Adipose Visceral Omentum	OIP5-AS1	0.23	0.16	lasso	10	0.11	2.8e-06	5.7	5.5	3.9e-08	0.75	0.11	0.89	FALSE
5	GTEx	Adrenal Gland	OIP5-AS1	0.17	0.16	lasso	3	0.16	2.6e-06	5.6	5.7	1.0e-08	0.76	0.09	0.89	FALSE
6	GTEx	Artery Coronary	OIP5-AS1	0.12	0.13	lasso	2	0.14	2.3e-05	5.7	5.7	1.3e-08	0.73	0.11	0.84	FALSE
7	GTEx	Artery Tibial	OIP5-AS1	0.16	0.23	lasso	4	0.24	3.6e-19	5.1	5.6	1.8e-08	0.76	0.28	0.72	FALSE
8	GTEx	Brain Caudate basal ganglia	NUSAP1	0.31	0.38	lasso	9	0.40	1.1e-12	5.4	5.8	6.5e-09	0.77	0.09	0.91	FALSE
9	GTEx	Brain Cerebellar Hemisphere	NUSAP1	0.24	0.31	lasso	6	0.22	2.0e-06	5.4	5.4	5.6e-08	0.79	0.10	0.89	FALSE
10	GTEx	Brain Cerebellar Hemisphere	NDUFAF1	0.20	0.23	lasso	6	0.22	2.2e-06	5.6	-5.8	5.3e-09	-0.76	0.09	0.89	FALSE
11	GTEx	Brain Cerebellum	NUSAP1	0.22	0.23	enet	18	0.22	3.7e-07	5.4	5.5	3.2e-08	0.77	0.10	0.90	FALSE
12	GTEx	Brain Cerebellum	NDUFAF1	0.24	0.26	lasso	8	0.20	1.1e-06	5.6	-5.6	1.8e-08	-0.76	0.06	0.94	FALSE
13	GTEx	Brain Cortex	NUSAP1	0.43	0.25	enet	27	0.26	8.7e-08	5.4	5.3	1.1e-07	0.74	0.09	0.91	FALSE
14	GTEx	Brain Cortex	NDUFAF1	0.40	0.37	enet	22	0.36	7.0e-11	5.2	-5.6	1.8e-08	-0.69	0.17	0.83	FALSE
15	GTEx	Brain Frontal Cortex BA9	NDUFAF1	0.55	0.37	lasso	8	0.40	1.6e-11	5.8	-5.9	3.7e-09	-0.74	0.08	0.92	FALSE
16	GTEx	Brain Hypothalamus	NUSAP1	0.26	0.36	lasso	4	0.27	5.6e-07	5.2	5.7	1.2e-08	0.65	0.12	0.85	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	NUSAP1	0.36	0.32	lasso	6	0.26	1.5e-07	5.8	5.6	1.7e-08	0.76	0.08	0.91	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	NDUFAF1	0.12	0.11	lasso	6	0.10	9.7e-04	5.6	-5.7	1.2e-08	-0.72	0.09	0.76	FALSE
19	GTEx	Brain Putamen basal ganglia	NUSAP1	0.38	0.30	lasso	20	0.34	9.1e-09	5.4	5.5	3.1e-08	0.74	0.11	0.89	FALSE
20	GTEx	Cells EBV-transformed lymphocytes	NDUFAF1	0.35	0.46	enet	14	0.51	3.1e-19	5.7	-5.2	2.3e-07	-0.72	0.08	0.92	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	OIP5-AS1	0.21	0.12	lasso	7	0.10	3.2e-04	5.8	5.9	2.8e-09	0.84	0.06	0.78	FALSE
22	GTEx	Cells Transformed fibroblasts	CHP1	0.13	0.11	lasso	6	0.11	2.1e-08	5.7	-6.0	2.6e-09	-0.92	0.07	0.93	FALSE
23	GTEx	Cells Transformed fibroblasts	OIP5-AS1	0.28	0.32	lasso	2	0.32	3.5e-24	5.8	5.8	6.8e-09	0.74	0.04	0.96	FALSE
24	GTEx	Colon Sigmoid	OIP5-AS1	0.21	0.27	lasso	3	0.25	3.3e-09	5.8	5.9	3.6e-09	0.76	0.10	0.90	FALSE
25	GTEx	Colon Transverse	OIP5-AS1	0.13	0.14	lasso	5	0.15	1.8e-07	5.8	5.8	8.4e-09	0.75	0.10	0.90	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	OIP5-AS1	0.18	0.10	lasso	7	0.11	8.9e-05	5.8	6.1	1.3e-09	0.86	0.07	0.90	TRUE
27	GTEx	Esophagus Mucosa	OIP5-AS1	0.20	0.22	lasso	6	0.20	1.7e-13	5.4	5.6	2.8e-08	0.75	0.17	0.83	FALSE
28	GTEx	Esophagus Muscularis	NDUFAF1	0.24	0.23	lasso	5	0.28	2.8e-17	5.7	-5.3	1.1e-07	-0.69	0.11	0.89	FALSE
29	GTEx	Esophagus Muscularis	OIP5-AS1	0.24	0.24	enet	19	0.28	4.6e-17	5.8	5.6	1.6e-08	0.73	0.11	0.89	FALSE
30	GTEx	Heart Atrial Appendage	NDUFAF1	0.36	0.28	enet	24	0.34	9.5e-16	5.8	-5.8	6.5e-09	-0.73	0.08	0.92	FALSE
31	GTEx	Heart Atrial Appendage	RTF1	0.14	0.07	lasso	4	0.08	2.4e-04	6.0	-5.9	3.2e-09	-0.97	0.01	0.97	FALSE
32	GTEx	Heart Left Ventricle	NDUFAF1	0.49	0.62	lasso	8	0.62	2.0e-41	5.6	-5.8	5.1e-09	-0.74	0.07	0.93	FALSE
33	GTEx	Muscle Skeletal	NDUFAF1	0.44	0.56	enet	31	0.60	3.0e-73	5.7	-5.5	3.0e-08	-0.77	0.07	0.93	FALSE
34	GTEx	Nerve Tibial	OIP5	0.07	0.08	lasso	2	0.05	1.6e-04	5.4	5.6	2.1e-08	0.90	0.02	0.98	FALSE
35	GTEx	Nerve Tibial	NUSAP1	0.15	0.09	enet	10	0.15	9.8e-11	5.6	5.8	5.0e-09	0.84	0.09	0.91	FALSE
36	GTEx	Nerve Tibial	NDUFAF1	0.36	0.43	lasso	6	0.43	8.0e-33	5.4	5.6	1.7e-08	0.73	0.09	0.91	FALSE
37	GTEx	Nerve Tibial	OIP5-AS1	0.20	0.22	enet	21	0.26	1.3e-18	5.7	5.7	1.2e-08	0.73	0.09	0.91	FALSE
38	GTEx	Pancreas	NDUFAF1	0.41	0.39	enet	20	0.42	2.7e-19	5.7	5.8	5.8e-09	0.74	0.08	0.92	FALSE
39	GTEx	Pancreas	OIP5-AS1	0.07	0.13	lasso	2	0.10	7.5e-05	5.1	5.3	1.2e-07	0.67	0.18	0.72	FALSE
40	GTEx	Pituitary	NUSAP1	0.16	0.12	lasso	2	0.16	7.4e-05	5.4	5.2	2.5e-07	0.73	0.10	0.81	FALSE
41	GTEx	Prostate	NDUFAF1	0.30	0.12	lasso	2	0.14	2.7e-04	5.7	6.0	1.9e-09	0.87	0.04	0.85	FALSE
42	GTEx	Skin Not Sun Exposed Suprapubic	OIP5-AS1	0.17	0.19	enet	17	0.22	4.3e-12	5.4	5.7	9.3e-09	0.79	0.11	0.89	FALSE
43	GTEx	Skin Sun Exposed Lower leg	CHP1	0.06	0.04	enet	9	0.04	3.1e-04	4.1	-5.1	2.7e-07	-0.73	0.33	0.38	FALSE
44	GTEx	Skin Sun Exposed Lower leg	OIP5-AS1	0.13	0.17	lasso	3	0.23	5.0e-19	5.2	5.7	1.3e-08	0.79	0.26	0.74	FALSE
45	GTEx	Thyroid	OIP5	0.06	0.03	lasso	5	0.02	1.1e-02	5.6	6.0	1.6e-09	0.75	0.10	0.78	FALSE
46	GTEx	Thyroid	NDUFAF1	0.25	0.21	lasso	6	0.22	9.3e-17	5.4	5.8	7.4e-09	0.79	0.10	0.90	FALSE
47	GTEx	Thyroid	OIP5-AS1	0.20	0.19	lasso	8	0.20	4.1e-15	5.1	5.3	1.2e-07	0.71	0.48	0.52	FALSE
48	GTEx	Whole Blood	NDUFAF1	0.25	0.07	lasso	6	0.12	6.4e-11	5.4	5.5	4.4e-08	0.80	0.07	0.93	FALSE
49	METSIM	Adipose	NDUFAF1	0.08	0.09	bslmm	296	0.09	2.4e-13	3.7	-5.2	1.7e-07	-0.64	0.20	0.80	FALSE
50	METSIM	Adipose	NUSAP1	0.03	0.03	lasso	6	0.02	4.2e-04	5.6	5.6	2.5e-08	0.76	0.11	0.84	FALSE
51	NTR	Blood	NUSAP1	0.03	0.03	lasso	3	0.04	4.9e-12	5.4	5.2	2.0e-07	0.77	0.17	0.83	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC729082	0.02	0.01	blup	44	0.02	2.9e-04	5.3	-5.1	2.7e-07	-0.73	0.04	0.93	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NUSAP1	0.03	0.01	blup	40	0.02	3.4e-03	5.6	-5.4	6.6e-08	-0.71	0.03	0.85	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	NDUFAF1	0.03	0.04	lasso	3	0.04	3.2e-05	5.7	-5.7	1.1e-08	-0.76	0.01	0.99	FALSE
55	The Cancer Genome Atlas	Lung Adenocarcinoma	NDUFAF1	0.14	0.17	lasso	5	0.18	9.6e-21	5.7	5.6	2.1e-08	0.72	0.01	0.99	FALSE
56	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NDUFAF1	0.23	0.15	lasso	3	0.13	3.7e-06	5.6	5.3	1.0e-07	0.76	0.02	0.98	FALSE
57	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LOC729082	0.15	0.05	blup	44	0.10	8.6e-05	5.8	-5.9	3.0e-09	-0.72	0.03	0.87	FALSE
58	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	NDUFAF1	0.18	0.21	blup	28	0.22	5.4e-09	5.7	5.6	2.0e-08	0.74	0.01	0.99	FALSE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC729082	0.04	0.07	lasso	1	0.06	5.5e-07	5.4	-5.4	5.1e-08	-0.78	0.04	0.96	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	NDUFAF1	0.13	0.16	enet	8	0.17	2.2e-17	5.7	5.5	3.0e-08	0.72	0.01	0.99	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	NDUFAF1	0.32	0.38	enet	11	0.39	1.2e-39	5.7	5.6	1.9e-08	0.74	0.01	0.99	FALSE