[Hub]/) : Traits : Leg fat percentage (right) :

chr15:40,828,922-42,468,786

Best TWAS P=1.3e-09 · Best GWAS P=7.09e-10 conditioned to 0.0617

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex NDUFAF1 0.14 0.16 bslmm 304 0.19 6.6e-23 5.3 -5.3 9.6e-08 -0.71 0.23 0.77 FALSE
2 CommonMind Brain Pre-frontal Cortex NUSAP1 0.20 0.24 bslmm 311 0.24 4.6e-29 5.6 5.3 1.1e-07 0.75 0.10 0.90 FALSE
3 GTEx Adipose Subcutaneous OIP5-AS1 0.21 0.23 lasso 5 0.26 3.7e-21 5.3 5.7 1.2e-08 0.74 0.16 0.84 FALSE
4 GTEx Adipose Visceral Omentum OIP5-AS1 0.23 0.16 lasso 10 0.11 2.8e-06 5.7 5.5 3.9e-08 0.75 0.11 0.89 FALSE
5 GTEx Adrenal Gland OIP5-AS1 0.17 0.16 lasso 3 0.16 2.6e-06 5.6 5.7 1.0e-08 0.76 0.09 0.89 FALSE
6 GTEx Artery Coronary OIP5-AS1 0.12 0.13 lasso 2 0.14 2.3e-05 5.7 5.7 1.3e-08 0.73 0.11 0.84 FALSE
7 GTEx Artery Tibial OIP5-AS1 0.16 0.23 lasso 4 0.24 3.6e-19 5.1 5.6 1.8e-08 0.76 0.28 0.72 FALSE
8 GTEx Brain Caudate basal ganglia NUSAP1 0.31 0.38 lasso 9 0.40 1.1e-12 5.4 5.8 6.5e-09 0.77 0.09 0.91 FALSE
9 GTEx Brain Cerebellar Hemisphere NUSAP1 0.24 0.31 lasso 6 0.22 2.0e-06 5.4 5.4 5.6e-08 0.79 0.10 0.89 FALSE
10 GTEx Brain Cerebellar Hemisphere NDUFAF1 0.20 0.23 lasso 6 0.22 2.2e-06 5.6 -5.8 5.3e-09 -0.76 0.09 0.89 FALSE
11 GTEx Brain Cerebellum NUSAP1 0.22 0.23 enet 18 0.22 3.7e-07 5.4 5.5 3.2e-08 0.77 0.10 0.90 FALSE
12 GTEx Brain Cerebellum NDUFAF1 0.24 0.26 lasso 8 0.20 1.1e-06 5.6 -5.6 1.8e-08 -0.76 0.06 0.94 FALSE
13 GTEx Brain Cortex NUSAP1 0.43 0.25 enet 27 0.26 8.7e-08 5.4 5.3 1.1e-07 0.74 0.09 0.91 FALSE
14 GTEx Brain Cortex NDUFAF1 0.40 0.37 enet 22 0.36 7.0e-11 5.2 -5.6 1.8e-08 -0.69 0.17 0.83 FALSE
15 GTEx Brain Frontal Cortex BA9 NDUFAF1 0.55 0.37 lasso 8 0.40 1.6e-11 5.8 -5.9 3.7e-09 -0.74 0.08 0.92 FALSE
16 GTEx Brain Hypothalamus NUSAP1 0.26 0.36 lasso 4 0.27 5.6e-07 5.2 5.7 1.2e-08 0.65 0.12 0.85 FALSE
17 GTEx Brain Nucleus accumbens basal ganglia NUSAP1 0.36 0.32 lasso 6 0.26 1.5e-07 5.8 5.6 1.7e-08 0.76 0.08 0.91 FALSE
18 GTEx Brain Nucleus accumbens basal ganglia NDUFAF1 0.12 0.11 lasso 6 0.10 9.7e-04 5.6 -5.7 1.2e-08 -0.72 0.09 0.76 FALSE
19 GTEx Brain Putamen basal ganglia NUSAP1 0.38 0.30 lasso 20 0.34 9.1e-09 5.4 5.5 3.1e-08 0.74 0.11 0.89 FALSE
20 GTEx Cells EBV-transformed lymphocytes NDUFAF1 0.35 0.46 enet 14 0.51 3.1e-19 5.7 -5.2 2.3e-07 -0.72 0.08 0.92 FALSE
21 GTEx Cells EBV-transformed lymphocytes OIP5-AS1 0.21 0.12 lasso 7 0.10 3.2e-04 5.8 5.9 2.8e-09 0.84 0.06 0.78 FALSE
22 GTEx Cells Transformed fibroblasts CHP1 0.13 0.11 lasso 6 0.11 2.1e-08 5.7 -6.0 2.6e-09 -0.92 0.07 0.93 FALSE
23 GTEx Cells Transformed fibroblasts OIP5-AS1 0.28 0.32 lasso 2 0.32 3.5e-24 5.8 5.8 6.8e-09 0.74 0.04 0.96 FALSE
24 GTEx Colon Sigmoid OIP5-AS1 0.21 0.27 lasso 3 0.25 3.3e-09 5.8 5.9 3.6e-09 0.76 0.10 0.90 FALSE
25 GTEx Colon Transverse OIP5-AS1 0.13 0.14 lasso 5 0.15 1.8e-07 5.8 5.8 8.4e-09 0.75 0.10 0.90 FALSE
26 GTEx Esophagus Gastroesophageal Junction OIP5-AS1 0.18 0.10 lasso 7 0.11 8.9e-05 5.8 6.1 1.3e-09 0.86 0.07 0.90 TRUE
27 GTEx Esophagus Mucosa OIP5-AS1 0.20 0.22 lasso 6 0.20 1.7e-13 5.4 5.6 2.8e-08 0.75 0.17 0.83 FALSE
28 GTEx Esophagus Muscularis NDUFAF1 0.24 0.23 lasso 5 0.28 2.8e-17 5.7 -5.3 1.1e-07 -0.69 0.11 0.89 FALSE
29 GTEx Esophagus Muscularis OIP5-AS1 0.24 0.24 enet 19 0.28 4.6e-17 5.8 5.6 1.6e-08 0.73 0.11 0.89 FALSE
30 GTEx Heart Atrial Appendage NDUFAF1 0.36 0.28 enet 24 0.34 9.5e-16 5.8 -5.8 6.5e-09 -0.73 0.08 0.92 FALSE
31 GTEx Heart Atrial Appendage RTF1 0.14 0.07 lasso 4 0.08 2.4e-04 6.0 -5.9 3.2e-09 -0.97 0.01 0.97 FALSE
32 GTEx Heart Left Ventricle NDUFAF1 0.49 0.62 lasso 8 0.62 2.0e-41 5.6 -5.8 5.1e-09 -0.74 0.07 0.93 FALSE
33 GTEx Muscle Skeletal NDUFAF1 0.44 0.56 enet 31 0.60 3.0e-73 5.7 -5.5 3.0e-08 -0.77 0.07 0.93 FALSE
34 GTEx Nerve Tibial OIP5 0.07 0.08 lasso 2 0.05 1.6e-04 5.4 5.6 2.1e-08 0.90 0.02 0.98 FALSE
35 GTEx Nerve Tibial NUSAP1 0.15 0.09 enet 10 0.15 9.8e-11 5.6 5.8 5.0e-09 0.84 0.09 0.91 FALSE
36 GTEx Nerve Tibial NDUFAF1 0.36 0.43 lasso 6 0.43 8.0e-33 5.4 5.6 1.7e-08 0.73 0.09 0.91 FALSE
37 GTEx Nerve Tibial OIP5-AS1 0.20 0.22 enet 21 0.26 1.3e-18 5.7 5.7 1.2e-08 0.73 0.09 0.91 FALSE
38 GTEx Pancreas NDUFAF1 0.41 0.39 enet 20 0.42 2.7e-19 5.7 5.8 5.8e-09 0.74 0.08 0.92 FALSE
39 GTEx Pancreas OIP5-AS1 0.07 0.13 lasso 2 0.10 7.5e-05 5.1 5.3 1.2e-07 0.67 0.18 0.72 FALSE
40 GTEx Pituitary NUSAP1 0.16 0.12 lasso 2 0.16 7.4e-05 5.4 5.2 2.5e-07 0.73 0.10 0.81 FALSE
41 GTEx Prostate NDUFAF1 0.30 0.12 lasso 2 0.14 2.7e-04 5.7 6.0 1.9e-09 0.87 0.04 0.85 FALSE
42 GTEx Skin Not Sun Exposed Suprapubic OIP5-AS1 0.17 0.19 enet 17 0.22 4.3e-12 5.4 5.7 9.3e-09 0.79 0.11 0.89 FALSE
43 GTEx Skin Sun Exposed Lower leg CHP1 0.06 0.04 enet 9 0.04 3.1e-04 4.1 -5.1 2.7e-07 -0.73 0.33 0.38 FALSE
44 GTEx Skin Sun Exposed Lower leg OIP5-AS1 0.13 0.17 lasso 3 0.23 5.0e-19 5.2 5.7 1.3e-08 0.79 0.26 0.74 FALSE
45 GTEx Thyroid OIP5 0.06 0.03 lasso 5 0.02 1.1e-02 5.6 6.0 1.6e-09 0.75 0.10 0.78 FALSE
46 GTEx Thyroid NDUFAF1 0.25 0.21 lasso 6 0.22 9.3e-17 5.4 5.8 7.4e-09 0.79 0.10 0.90 FALSE
47 GTEx Thyroid OIP5-AS1 0.20 0.19 lasso 8 0.20 4.1e-15 5.1 5.3 1.2e-07 0.71 0.48 0.52 FALSE
48 GTEx Whole Blood NDUFAF1 0.25 0.07 lasso 6 0.12 6.4e-11 5.4 5.5 4.4e-08 0.80 0.07 0.93 FALSE
49 METSIM Adipose NDUFAF1 0.08 0.09 bslmm 296 0.09 2.4e-13 3.7 -5.2 1.7e-07 -0.64 0.20 0.80 FALSE
50 METSIM Adipose NUSAP1 0.03 0.03 lasso 6 0.02 4.2e-04 5.6 5.6 2.5e-08 0.76 0.11 0.84 FALSE
51 NTR Blood NUSAP1 0.03 0.03 lasso 3 0.04 4.9e-12 5.4 5.2 2.0e-07 0.77 0.17 0.83 FALSE
52 The Cancer Genome Atlas Breast Invasive Carcinoma LOC729082 0.02 0.01 blup 44 0.02 2.9e-04 5.3 -5.1 2.7e-07 -0.73 0.04 0.93 FALSE
53 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NUSAP1 0.03 0.01 blup 40 0.02 3.4e-03 5.6 -5.4 6.6e-08 -0.71 0.03 0.85 FALSE
54 The Cancer Genome Atlas Brain Lower Grade Glioma NDUFAF1 0.03 0.04 lasso 3 0.04 3.2e-05 5.7 -5.7 1.1e-08 -0.76 0.01 0.99 FALSE
55 The Cancer Genome Atlas Lung Adenocarcinoma NDUFAF1 0.14 0.17 lasso 5 0.18 9.6e-21 5.7 5.6 2.1e-08 0.72 0.01 0.99 FALSE
56 The Cancer Genome Atlas Pancreatic Adenocarcinoma NDUFAF1 0.23 0.15 lasso 3 0.13 3.7e-06 5.6 5.3 1.0e-07 0.76 0.02 0.98 FALSE
57 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma LOC729082 0.15 0.05 blup 44 0.10 8.6e-05 5.8 -5.9 3.0e-09 -0.72 0.03 0.87 FALSE
58 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma NDUFAF1 0.18 0.21 blup 28 0.22 5.4e-09 5.7 5.6 2.0e-08 0.74 0.01 0.99 FALSE
59 The Cancer Genome Atlas Prostate Adenocarcinoma LOC729082 0.04 0.07 lasso 1 0.06 5.5e-07 5.4 -5.4 5.1e-08 -0.78 0.04 0.96 FALSE
60 The Cancer Genome Atlas Prostate Adenocarcinoma NDUFAF1 0.13 0.16 enet 8 0.17 2.2e-17 5.7 5.5 3.0e-08 0.72 0.01 0.99 FALSE
61 The Cancer Genome Atlas Thyroid Carcinoma NDUFAF1 0.32 0.38 enet 11 0.39 1.2e-39 5.7 5.6 1.9e-08 0.74 0.01 0.99 FALSE